WWC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)5.38598268
2cysteine metabolic process (GO:0006534)5.15081303
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.80103888
4L-phenylalanine catabolic process (GO:0006559)4.80103888
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.73118677
6L-phenylalanine metabolic process (GO:0006558)4.73118677
7lysine metabolic process (GO:0006553)4.53027489
8lysine catabolic process (GO:0006554)4.53027489
9aromatic amino acid family catabolic process (GO:0009074)4.35149971
10alpha-linolenic acid metabolic process (GO:0036109)4.32805149
11sulfur amino acid catabolic process (GO:0000098)4.28060401
12glyoxylate metabolic process (GO:0046487)4.13248645
13apical protein localization (GO:0045176)4.12687214
14kynurenine metabolic process (GO:0070189)4.07027007
15glutamate metabolic process (GO:0006536)4.02053747
16drug catabolic process (GO:0042737)3.97804569
17asymmetric protein localization (GO:0008105)3.97216983
18tryptophan catabolic process (GO:0006569)3.96701424
19indole-containing compound catabolic process (GO:0042436)3.96701424
20indolalkylamine catabolic process (GO:0046218)3.96701424
21homocysteine metabolic process (GO:0050667)3.96485482
22bundle of His cell to Purkinje myocyte communication (GO:0086069)3.94787999
23regulation of cholesterol homeostasis (GO:2000188)3.85283915
24cellular modified amino acid catabolic process (GO:0042219)3.82148775
25triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.78604815
26phosphate ion transmembrane transport (GO:0035435)3.77876885
27branching involved in salivary gland morphogenesis (GO:0060445)3.76166305
28bile acid biosynthetic process (GO:0006699)3.75635877
29tryptophan metabolic process (GO:0006568)3.72639382
30serine family amino acid catabolic process (GO:0009071)3.69230339
31phosphate ion transport (GO:0006817)3.68876643
32regulation of water loss via skin (GO:0033561)3.62309437
33urea cycle (GO:0000050)3.58595841
34urea metabolic process (GO:0019627)3.58595841
35amino-acid betaine metabolic process (GO:0006577)3.55941009
36notochord development (GO:0030903)3.55284963
37exogenous drug catabolic process (GO:0042738)3.53266665
38urate metabolic process (GO:0046415)3.51703886
39cellular ketone body metabolic process (GO:0046950)3.45422668
40drug transmembrane transport (GO:0006855)3.42045055
41dicarboxylic acid biosynthetic process (GO:0043650)3.41268734
42aspartate family amino acid catabolic process (GO:0009068)3.39708908
43establishment of apical/basal cell polarity (GO:0035089)3.38509674
44negative regulation of fibrinolysis (GO:0051918)3.37798371
45ethanol oxidation (GO:0006069)3.37105037
46negative regulation of cholesterol transport (GO:0032375)3.35671175
47negative regulation of sterol transport (GO:0032372)3.35671175
48hemidesmosome assembly (GO:0031581)3.31656065
49epithelial cell-cell adhesion (GO:0090136)3.30846972
50fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.27886493
51tight junction assembly (GO:0070830)3.27744886
52high-density lipoprotein particle remodeling (GO:0034375)3.25425991
53pattern specification involved in kidney development (GO:0061004)3.25248421
54nitrogen cycle metabolic process (GO:0071941)3.25049926
55alpha-amino acid catabolic process (GO:1901606)3.23843795
56activation of Rac GTPase activity (GO:0032863)3.23561810
57bile acid metabolic process (GO:0008206)3.22335710
58establishment of skin barrier (GO:0061436)3.20156770
59serine family amino acid metabolic process (GO:0009069)3.19513805
60cellular amino acid catabolic process (GO:0009063)3.17139215
61multicellular organismal water homeostasis (GO:0050891)3.14898052
62short-chain fatty acid metabolic process (GO:0046459)3.14515656
63reverse cholesterol transport (GO:0043691)3.13313553
64intestinal epithelial cell development (GO:0060576)3.10854343
65aromatic amino acid family metabolic process (GO:0009072)3.08766294
66protein carboxylation (GO:0018214)3.06323668
67peptidyl-glutamic acid carboxylation (GO:0017187)3.06323668
68intestinal cholesterol absorption (GO:0030299)3.05639284
69regulation of protein activation cascade (GO:2000257)3.05067373
70regulation of bile acid biosynthetic process (GO:0070857)2.99143421
71complement activation, alternative pathway (GO:0006957)2.98980152
72surfactant homeostasis (GO:0043129)2.97989194
73flavonoid metabolic process (GO:0009812)2.97016922
74gap junction assembly (GO:0016264)2.96638020
75biotin metabolic process (GO:0006768)2.95338763
76regulation of fibrinolysis (GO:0051917)2.94908155
77endothelial cell chemotaxis (GO:0035767)2.94043924
78lung epithelium development (GO:0060428)2.93315797
79ketone body metabolic process (GO:1902224)2.93116319
80planar cell polarity pathway involved in neural tube closure (GO:0090179)2.92329951
81response to mercury ion (GO:0046689)2.91871889
82regulation of complement activation (GO:0030449)2.88385182
83drug transport (GO:0015893)2.87317569
84regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.86926936
85response to nitrosative stress (GO:0051409)2.85765049
86midgut development (GO:0007494)2.84371078
87serine family amino acid biosynthetic process (GO:0009070)2.81609748
88acetyl-CoA metabolic process (GO:0006084)2.81572506
89cellular glucuronidation (GO:0052695)2.79474321
90benzene-containing compound metabolic process (GO:0042537)2.78935492
91cell-cell junction assembly (GO:0007043)2.78005803
92nephron tubule formation (GO:0072079)2.77728033
93hormone catabolic process (GO:0042447)2.77709565
94pyrimidine nucleobase catabolic process (GO:0006208)2.76477375
95establishment of monopolar cell polarity (GO:0061162)2.75979219
96establishment or maintenance of monopolar cell polarity (GO:0061339)2.75979219
97protein-lipid complex remodeling (GO:0034368)2.75637289
98macromolecular complex remodeling (GO:0034367)2.75637289
99plasma lipoprotein particle remodeling (GO:0034369)2.75637289
100establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.75023590
1012-oxoglutarate metabolic process (GO:0006103)2.74255741
102negative regulation of keratinocyte proliferation (GO:0010839)2.73971669
103myelin maintenance (GO:0043217)2.73945611
104embryonic retina morphogenesis in camera-type eye (GO:0060059)2.73817029
105coenzyme catabolic process (GO:0009109)2.72571161
106tyrosine metabolic process (GO:0006570)2.71969740
107regulation of cholesterol esterification (GO:0010872)2.69900062
108establishment or maintenance of apical/basal cell polarity (GO:0035088)2.68818486
109establishment or maintenance of bipolar cell polarity (GO:0061245)2.68818486
110chemical homeostasis within a tissue (GO:0048875)2.68351907
111regulation of triglyceride catabolic process (GO:0010896)2.66824418
112epoxygenase P450 pathway (GO:0019373)2.64722839
113paraxial mesoderm development (GO:0048339)2.64402162
114organic acid catabolic process (GO:0016054)2.64396536
115carboxylic acid catabolic process (GO:0046395)2.64396536
116indolalkylamine metabolic process (GO:0006586)2.64285786
117regulation of cholesterol biosynthetic process (GO:0045540)2.64153996
118water homeostasis (GO:0030104)2.63998859
119regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.63687939
120drug metabolic process (GO:0017144)2.63393897
121carnitine metabolic process (GO:0009437)2.63305186
122dicarboxylic acid catabolic process (GO:0043649)2.62095653
123triglyceride homeostasis (GO:0070328)2.61882452
124acylglycerol homeostasis (GO:0055090)2.61882452
125nucleobase catabolic process (GO:0046113)2.61849956
126L-ascorbic acid metabolic process (GO:0019852)2.58022589
127bile acid and bile salt transport (GO:0015721)2.57233172
128phospholipid homeostasis (GO:0055091)2.56981205
129glycine metabolic process (GO:0006544)2.56497782
130polarized epithelial cell differentiation (GO:0030859)2.56184541
131cytoskeletal anchoring at plasma membrane (GO:0007016)2.55664813
132ear development (GO:0043583)2.55236974
133layer formation in cerebral cortex (GO:0021819)2.54810938
134auditory receptor cell differentiation (GO:0042491)2.54582871
135arginine metabolic process (GO:0006525)2.54293640
136phospholipid efflux (GO:0033700)2.53281523
137ethanol metabolic process (GO:0006067)2.52685463
138COPI coating of Golgi vesicle (GO:0048205)2.52044523
139Golgi transport vesicle coating (GO:0048200)2.52044523
140Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.50670801
141regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.49192428
142cell-cell junction maintenance (GO:0045217)2.48724643
143calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.42397301
144regulation of cell proliferation involved in kidney development (GO:1901722)2.40912284
145protein localization to microtubule (GO:0035372)2.40551507
146protein autoprocessing (GO:0016540)2.38145247
147regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.38102486
148semaphorin-plexin signaling pathway (GO:0071526)2.36891263
149regulation of establishment of planar polarity (GO:0090175)2.35047801
150dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.33953167
151establishment of planar polarity (GO:0001736)2.33672820
152establishment of tissue polarity (GO:0007164)2.33672820
153axon ensheathment in central nervous system (GO:0032291)2.31593832
154central nervous system myelination (GO:0022010)2.31593832
155regulation of apoptotic process involved in morphogenesis (GO:1902337)2.29992202
156regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.28682917
157* hippo signaling (GO:0035329)2.28483488
158epithelial tube branching involved in lung morphogenesis (GO:0060441)2.28083230
159ectoderm development (GO:0007398)2.27779251
160branching involved in mammary gland duct morphogenesis (GO:0060444)2.27440900
161adherens junction assembly (GO:0034333)2.26066105
162regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.24851190
163positive regulation of epidermal cell differentiation (GO:0045606)2.24330613
164mating behavior (GO:0007617)2.22707446
165primary alcohol catabolic process (GO:0034310)2.21681766
166morphogenesis of embryonic epithelium (GO:0016331)2.21279417
167atrioventricular valve morphogenesis (GO:0003181)2.20252229
168negative regulation of cell fate specification (GO:0009996)2.19463022
169retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.19333744
170cell-substrate adherens junction assembly (GO:0007045)2.18308919
171focal adhesion assembly (GO:0048041)2.18308919
172non-canonical Wnt signaling pathway (GO:0035567)2.17770104
173positive regulation of keratinocyte differentiation (GO:0045618)2.17698878
174positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.14178875
175negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.13907284
176cell junction maintenance (GO:0034331)2.12230124
177glomerular epithelial cell development (GO:0072310)2.10050375
178metanephric nephron epithelium development (GO:0072243)2.10029059
179regulation of mesenchymal cell apoptotic process (GO:2001053)2.08720616
180regulation of endothelial cell chemotaxis (GO:2001026)2.07892714
181cell-substrate junction assembly (GO:0007044)2.07711391
182synaptic vesicle docking involved in exocytosis (GO:0016081)2.07705408
183camera-type eye morphogenesis (GO:0048593)2.07038516
184lateral sprouting from an epithelium (GO:0060601)2.06759740
185collecting duct development (GO:0072044)2.05958077
186regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.05869693
187ER overload response (GO:0006983)2.04876427
188cell-cell junction organization (GO:0045216)2.04596698
189iron ion import (GO:0097286)2.02726122
190negative regulation of cell fate commitment (GO:0010454)2.02352781
191embryonic eye morphogenesis (GO:0048048)2.02272996
192cell junction assembly (GO:0034329)2.01949200
193sodium ion export (GO:0071436)2.01838516

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.66330589
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.13780608
3PPARA_22158963_ChIP-Seq_LIVER_Mouse3.59993318
4* LXR_22158963_ChIP-Seq_LIVER_Mouse3.49440687
5* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.62681860
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.61463354
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.54270088
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.51491321
9AR_21909140_ChIP-Seq_LNCAP_Human2.29381383
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.27883279
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.23053197
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.22302817
13TRIM28_21343339_ChIP-Seq_HEK293_Human1.99541750
14EGR1_23403033_ChIP-Seq_LIVER_Mouse1.96515128
15HIF1A_21447827_ChIP-Seq_MCF-7_Human1.93889559
16CLOCK_20551151_ChIP-Seq_293T_Human1.88134044
17ZNF263_19887448_ChIP-Seq_K562_Human1.86408074
18ERG_21242973_ChIP-ChIP_JURKAT_Human1.86340059
19ESR1_21235772_ChIP-Seq_MCF-7_Human1.83430854
20RARG_19884340_ChIP-ChIP_MEFs_Mouse1.82921056
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.74813023
22CDX2_20551321_ChIP-Seq_CACO-2_Human1.60869484
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56988026
24* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.56577127
25* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.56577127
26FOXA2_19822575_ChIP-Seq_HepG2_Human1.56311629
27SOX2_27498859_Chip-Seq_STOMACH_Mouse1.54284623
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52810083
29ESR1_20079471_ChIP-ChIP_T-47D_Human1.51781715
30* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51594742
31ATF3_27146783_Chip-Seq_COLON_Human1.50651376
32GATA3_24758297_ChIP-Seq_MCF-7_Human1.49110897
33SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.48374998
34CTNNB1_20460455_ChIP-Seq_HCT116_Human1.46475282
35ESR1_15608294_ChIP-ChIP_MCF-7_Human1.45981545
36ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.43957005
37* KLF5_25053715_ChIP-Seq_YYC3_Human1.40585696
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.40473202
39TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.40203474
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.35529778
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.34518553
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34448952
43DROSHA_22980978_ChIP-Seq_HELA_Human1.33854673
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.31228007
45AHR_22903824_ChIP-Seq_MCF-7_Human1.30358244
46SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.29668707
47CHD1_26751641_Chip-Seq_LNCaP_Human1.25720382
48RNF2_18974828_ChIP-Seq_MESCs_Mouse1.25595733
49EZH2_18974828_ChIP-Seq_MESCs_Mouse1.25595733
50KDM2B_26808549_Chip-Seq_K562_Human1.24900235
51TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.24449614
52RACK7_27058665_Chip-Seq_MCF-7_Human1.24203938
53MTF2_20144788_ChIP-Seq_MESCs_Mouse1.24066073
54LXR_22292898_ChIP-Seq_THP-1_Human1.20478846
55SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20423713
56TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19536225
57* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18273525
58CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.17775378
59JARID2_20075857_ChIP-Seq_MESCs_Mouse1.16891171
60* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15929693
61SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.12735515
62FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.12153211
63ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12013107
64RARB_27405468_Chip-Seq_BRAIN_Mouse1.11273654
65* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.10225349
66ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09948052
67RUNX1_27514584_Chip-Seq_MCF-7_Human1.08537475
68* ARNT_22903824_ChIP-Seq_MCF-7_Human1.07987765
69* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07811182
70* GATA4_25053715_ChIP-Seq_YYC3_Human1.06933189
71ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06930001
72SMC4_20622854_ChIP-Seq_HELA_Human1.06487653
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06482016
74NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06346559
75UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05971544
76* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05821352
77* RING1B_27294783_Chip-Seq_NPCs_Mouse1.04802133
78ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04307021
79SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04125669
80SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03855217
81P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03815280
82AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.02497058
83* HNF4A_19822575_ChIP-Seq_HepG2_Human1.01872648
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01431191
85PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00792216
86SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00784790
87TET1_21490601_ChIP-Seq_MESCs_Mouse1.00742603
88DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00026749
89* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99529349
90NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99411793
91EZH2_27294783_Chip-Seq_ESCs_Mouse0.99261660
92SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98551070
93FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98208944
94CREB1_26743006_Chip-Seq_LNCaP_Human0.97940362
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97860239
96SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.97801731
97* SOX2_20726797_ChIP-Seq_SW620_Human0.97597031
98FOXA1_25552417_ChIP-Seq_VCAP_Human0.96876618
99HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95843122
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95393185
101NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95309605
102TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94436918
103SMAD4_21741376_ChIP-Seq_HESCs_Human0.93708932
104P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93498314
105UBF1/2_26484160_Chip-Seq_HMECs_Human0.92513548
106* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91820715
107JARID2_20064375_ChIP-Seq_MESCs_Mouse0.91088397
108* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90794257
109* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89915354
110RING1B_27294783_Chip-Seq_ESCs_Mouse0.89493813
111POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.88179643
112GATA6_25053715_ChIP-Seq_YYC3_Human0.88085231
113KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.87703221
114NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.87599170
115ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.87403988
116* SMAD3_21741376_ChIP-Seq_HESCs_Human0.87039704
117ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.86711220
118PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86618108
119TP53_22127205_ChIP-Seq_IMR90_Human0.86352570
120SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.86189339
121TP63_22573176_ChIP-Seq_HFKS_Human0.86182212
122FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86029699
123* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.85643236
124CTCF_27219007_Chip-Seq_Bcells_Human0.85340612
125PIAS1_25552417_ChIP-Seq_VCAP_Human0.85018581
126* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.84923933
127FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84913475
128SALL4_18804426_ChIP-ChIP_XEN_Mouse0.84552220
129KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84146812
130ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.83952695
131TET1_21451524_ChIP-Seq_MESCs_Mouse0.83903619
132EED_16625203_ChIP-ChIP_MESCs_Mouse0.83743307
133RNF2_27304074_Chip-Seq_ESCs_Mouse0.83115713
134SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.82522163
135* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.81893331
136RXR_22108803_ChIP-Seq_LS180_Human0.81877091
137YAP1_20516196_ChIP-Seq_MESCs_Mouse0.81429603
138* ELF5_23300383_ChIP-Seq_T47D_Human0.80736604
139HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80327495
140POU5F1_16518401_ChIP-PET_MESCs_Mouse0.80297508

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.16566427
2MP0005360_urolithiasis5.97850344
3MP0005085_abnormal_gallbladder_physiolo4.42969537
4MP0005365_abnormal_bile_salt4.06480692
5MP0008875_abnormal_xenobiotic_pharmacok3.69764079
6MP0010234_abnormal_vibrissa_follicle3.44959728
7MP0003252_abnormal_bile_duct3.38449127
8MP0002138_abnormal_hepatobiliary_system2.85277244
9MP0001666_abnormal_nutrient_absorption2.65044842
10MP0005083_abnormal_biliary_tract2.62040112
11MP0005332_abnormal_amino_acid2.60697712
12MP0010329_abnormal_lipoprotein_level2.46788320
13MP0004019_abnormal_vitamin_homeostasis2.41856019
14MP0000383_abnormal_hair_follicle2.29408222
15MP0003705_abnormal_hypodermis_morpholog2.21048757
16MP0003136_yellow_coat_color2.11102094
17MP0003806_abnormal_nucleotide_metabolis2.02930959
18MP0003195_calcinosis1.91370177
19MP0004859_abnormal_synaptic_plasticity1.87980690
20MP0004858_abnormal_nervous_system1.84363755
21MP0005076_abnormal_cell_differentiation1.81400258
22MP0010352_gastrointestinal_tract_polyps1.79225852
23MP0009780_abnormal_chondrocyte_physiolo1.74685925
24MP0000762_abnormal_tongue_morphology1.73970476
25MP0004885_abnormal_endolymph1.70836035
26MP0004043_abnormal_pH_regulation1.66126893
27MP0003941_abnormal_skin_development1.64602285
28MP0003329_amyloid_beta_deposits1.64542525
29MP0000537_abnormal_urethra_morphology1.62795492
30MP0009840_abnormal_foam_cell1.60954112
31MP0003191_abnormal_cellular_cholesterol1.57349333
32MP0009643_abnormal_urine_homeostasis1.53856509
33MP0004233_abnormal_muscle_weight1.49964294
34MP0002118_abnormal_lipid_homeostasis1.49360484
35MP0004185_abnormal_adipocyte_glucose1.47914292
36MP0002796_impaired_skin_barrier1.44175191
37MP0002254_reproductive_system_inflammat1.41633502
38MP0004264_abnormal_extraembryonic_tissu1.38867684
39MP0003868_abnormal_feces_composition1.35849052
40MP0005167_abnormal_blood-brain_barrier1.34133209
41MP0002697_abnormal_eye_size1.33296419
42MP0001346_abnormal_lacrimal_gland1.33243751
43MP0001756_abnormal_urination1.31063355
44MP0000377_abnormal_hair_follicle1.29477177
45MP0000678_abnormal_parathyroid_gland1.28457872
46MP0010771_integument_phenotype1.25811952
47MP0002249_abnormal_larynx_morphology1.25755291
48MP0001216_abnormal_epidermal_layer1.23599937
49MP0003283_abnormal_digestive_organ1.22109837
50MP0000647_abnormal_sebaceous_gland1.21997942
51MP0005409_darkened_coat_color1.21207586
52MP0001958_emphysema1.17926887
53MP0002877_abnormal_melanocyte_morpholog1.17060247
54MP0001765_abnormal_ion_homeostasis1.16557681
55MP0000609_abnormal_liver_physiology1.16390391
56MP0005084_abnormal_gallbladder_morpholo1.15189540
57MP0000627_abnormal_mammary_gland1.15144732
58MP0008961_abnormal_basal_metabolism1.14321594
59MP0010030_abnormal_orbit_morphology1.14013784
60MP0004782_abnormal_surfactant_physiolog1.12366706
61MP0003300_gastrointestinal_ulcer1.11575417
62MP0005319_abnormal_enzyme/_coenzyme1.08407810
63MP0000604_amyloidosis1.07402989
64MP0001177_atelectasis1.07297052
65MP0009053_abnormal_anal_canal1.06368762
66MP0005248_abnormal_Harderian_gland1.04138834
67MP0002928_abnormal_bile_duct1.03100651
68MP0005257_abnormal_intraocular_pressure1.01503766
69MP0005636_abnormal_mineral_homeostasis1.00600401
70MP0002876_abnormal_thyroid_physiology1.00573090
71MP0005584_abnormal_enzyme/coenzyme_acti0.99966827
72MP0010678_abnormal_skin_adnexa0.98946699
73MP0000427_abnormal_hair_cycle0.97990867
74MP0000534_abnormal_ureter_morphology0.96875390
75MP0009379_abnormal_foot_pigmentation0.94666322
76MP0009672_abnormal_birth_weight0.92700697
77MP0000003_abnormal_adipose_tissue0.91746151
78MP0002136_abnormal_kidney_physiology0.91005599
79MP0005377_hearing/vestibular/ear_phenot0.90517861
80MP0003878_abnormal_ear_physiology0.90517861
81MP0001849_ear_inflammation0.90132658
82MP0004270_analgesia0.89023642
83MP0003755_abnormal_palate_morphology0.88531303
84MP0003075_altered_response_to0.88279903
85MP0005220_abnormal_exocrine_pancreas0.88008864
86MP0002234_abnormal_pharynx_morphology0.86240633
87MP0003937_abnormal_limbs/digits/tail_de0.85871089
88MP0002822_catalepsy0.84834718
89MP0009384_cardiac_valve_regurgitation0.84776260
90MP0002168_other_aberrant_phenotype0.84172357
91MP0003936_abnormal_reproductive_system0.83782687
92MP0003879_abnormal_hair_cell0.81775702
93MP0003635_abnormal_synaptic_transmissio0.81231849
94MP0000613_abnormal_salivary_gland0.81126859
95MP0002084_abnormal_developmental_patter0.80809338
96MP0002653_abnormal_ependyma_morphology0.80362263
97MP0001944_abnormal_pancreas_morphology0.80346508
98MP0002736_abnormal_nociception_after0.80227656
99MP0002060_abnormal_skin_morphology0.80133835
100MP0003183_abnormal_peptide_metabolism0.79923504
101MP0005023_abnormal_wound_healing0.79529833
102MP0002909_abnormal_adrenal_gland0.79347644
103MP0004272_abnormal_basement_membrane0.78568706
104MP0002111_abnormal_tail_morphology0.75828805
105MP0001502_abnormal_circadian_rhythm0.75361865
106MP0000579_abnormal_nail_morphology0.75361722
107MP0000566_synostosis0.75142685
108MP0003315_abnormal_perineum_morphology0.74937535
109MP0005666_abnormal_adipose_tissue0.73846477
110MP0005187_abnormal_penis_morphology0.73830590
111MP0002063_abnormal_learning/memory/cond0.73155868
112MP0003938_abnormal_ear_development0.72702308
113MP0003861_abnormal_nervous_system0.72234799
114MP0003115_abnormal_respiratory_system0.72234529
115MP0003638_abnormal_response/metabolism_0.70838143
116MP0003690_abnormal_glial_cell0.70505759
117MP0008004_abnormal_stomach_pH0.69700803
118MP0002085_abnormal_embryonic_tissue0.69693087
119MP0003943_abnormal_hepatobiliary_system0.69549048
120MP0001881_abnormal_mammary_gland0.69025700
121MP0003119_abnormal_digestive_system0.68745805
122MP0002092_abnormal_eye_morphology0.68600334
123MP0001286_abnormal_eye_development0.68225293
124MP0001340_abnormal_eyelid_morphology0.67833517
125MP0005623_abnormal_meninges_morphology0.67304746
126MP0000432_abnormal_head_morphology0.67053945
127MP0010368_abnormal_lymphatic_system0.66672281
128MP0003693_abnormal_embryo_hatching0.66650134
129MP0000462_abnormal_digestive_system0.66274517
130MP0005375_adipose_tissue_phenotype0.66093032
131MP0008872_abnormal_physiological_respon0.65635007
132MP0005501_abnormal_skin_physiology0.65470228
133MP0004130_abnormal_muscle_cell0.63828723
134MP0002295_abnormal_pulmonary_circulatio0.62866440
135MP0000538_abnormal_urinary_bladder0.62641570
136MP0004133_heterotaxia0.61814089
137MP0002896_abnormal_bone_mineralization0.61086635
138MP0002089_abnormal_postnatal_growth/wei0.59474501
139MP0003453_abnormal_keratinocyte_physiol0.59372896
140MP0000778_abnormal_nervous_system0.58660388
141MP0001664_abnormal_digestion0.57809150
142MP0003942_abnormal_urinary_system0.57606668
143MP0005166_decreased_susceptibility_to0.57584419
144MP0001485_abnormal_pinna_reflex0.57260432
145MP0002098_abnormal_vibrissa_morphology0.55474633
146MP0000467_abnormal_esophagus_morphology0.53703032
147MP0000598_abnormal_liver_morphology0.52598393
148MP0009745_abnormal_behavioral_response0.51601593
149MP0003632_abnormal_nervous_system0.50942344
150MP0003566_abnormal_cell_adhesion0.50518347
151MP0002069_abnormal_eating/drinking_beha0.48997695
152MP0001440_abnormal_grooming_behavior0.47680766

Predicted human phenotypes

RankGene SetZ-score
1Gout (HP:0001997)5.31819797
2Deep venous thrombosis (HP:0002625)4.72597112
3Intrahepatic cholestasis (HP:0001406)4.34169540
4Abnormality of monocarboxylic acid metabolism (HP:0010996)4.22983318
5Hyperactive renin-angiotensin system (HP:0000841)4.17860507
6Abnormality of aromatic amino acid family metabolism (HP:0004338)3.99877127
7Abnormality of glutamine family amino acid metabolism (HP:0010902)3.90735250
8Xanthomatosis (HP:0000991)3.84335092
9Hyperglycinuria (HP:0003108)3.68786949
10Hypokalemic alkalosis (HP:0001949)3.47089780
11Hypobetalipoproteinemia (HP:0003563)3.35030794
12Abnormality of glycine metabolism (HP:0010895)3.33801390
13Abnormality of serine family amino acid metabolism (HP:0010894)3.33801390
14Renal salt wasting (HP:0000127)3.28258733
15Hyperglycinemia (HP:0002154)3.15861856
16Increased purine levels (HP:0004368)3.13644999
17Hyperuricemia (HP:0002149)3.13644999
18Abnormality of chloride homeostasis (HP:0011422)3.10127690
19Abnormality of purine metabolism (HP:0004352)3.09843030
20Ketosis (HP:0001946)3.09340069
21Potter facies (HP:0002009)3.07214612
22Facial shape deformation (HP:0011334)3.07214612
23Metabolic alkalosis (HP:0200114)3.06074178
24Increased circulating renin level (HP:0000848)3.02417415
25Hyperammonemia (HP:0001987)2.95517769
26Broad face (HP:0000283)2.93337246
27Delayed CNS myelination (HP:0002188)2.88976970
28Ketoacidosis (HP:0001993)2.88945124
29Abnormality of sulfur amino acid metabolism (HP:0004339)2.87251545
30Alkalosis (HP:0001948)2.86035676
31Complement deficiency (HP:0004431)2.85235785
32Spastic diplegia (HP:0001264)2.78511853
33Hyperacusis (HP:0010780)2.75785859
34Esophageal varix (HP:0002040)2.75264668
35Hyperlipoproteinemia (HP:0010980)2.73867098
36Epidermoid cyst (HP:0200040)2.71630932
37Glomerulosclerosis (HP:0000096)2.68896871
38Vascular calcification (HP:0004934)2.68059963
39Malnutrition (HP:0004395)2.67427298
40Hyperaldosteronism (HP:0000859)2.65454542
41Fat malabsorption (HP:0002630)2.62754686
42Pili torti (HP:0003777)2.61165304
43Abnormality of renal excretion (HP:0011036)2.60245987
44Short nail (HP:0001799)2.60099641
45Hypolipoproteinemia (HP:0010981)2.59584531
46Abnormality of permanent molar morphology (HP:0011071)2.56604146
47Abnormality of the dental root (HP:0006486)2.56604146
48Taurodontia (HP:0000679)2.56604146
49Abnormality of aspartate family amino acid metabolism (HP:0010899)2.55443296
50Turricephaly (HP:0000262)2.54309389
51Tubulointerstitial fibrosis (HP:0005576)2.54167431
52Abnormality of nucleobase metabolism (HP:0010932)2.51688442
53Abnormal urine output (HP:0012590)2.51146983
54Cerebral inclusion bodies (HP:0100314)2.40041128
55Focal segmental glomerulosclerosis (HP:0000097)2.39787732
56Aplasia involving bones of the upper limbs (HP:0009823)2.38168023
57Aplasia of the phalanges of the hand (HP:0009802)2.38168023
58Aplasia involving bones of the extremities (HP:0009825)2.38168023
59Cardiovascular calcification (HP:0011915)2.37690306
60Flat acetabular roof (HP:0003180)2.37422438
61Hypoalphalipoproteinemia (HP:0003233)2.36554906
62Back pain (HP:0003418)2.36163195
63Prolonged partial thromboplastin time (HP:0003645)2.35582457
64Bronchomalacia (HP:0002780)2.35291289
65Hepatocellular carcinoma (HP:0001402)2.33812768
66Abnormality of the distal phalanges of the toes (HP:0010182)2.33463773
67Abnormality of renin-angiotensin system (HP:0000847)2.31804188
68Neonatal onset (HP:0003623)2.31715957
69Abnormality of the distal phalanx of the thumb (HP:0009617)2.29132907
70Ulnar bowing (HP:0003031)2.26080097
71Abnormality of the dental pulp (HP:0006479)2.25754810
72Abnormality of molar morphology (HP:0011070)2.25029177
73Abnormality of molar (HP:0011077)2.25029177
74Sensorimotor neuropathy (HP:0007141)2.23045768
75Polyuria (HP:0000103)2.20616003
76Abnormality of the nasal septum (HP:0000419)2.19037443
77Abnormality of the common coagulation pathway (HP:0010990)2.19034133
78Hypoplasia of dental enamel (HP:0006297)2.18549719
79Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.16789417
80Septate vagina (HP:0001153)2.16164784
81Lip pit (HP:0100267)2.15575990
82Right ventricular cardiomyopathy (HP:0011663)2.15168136
83Abnormality of proline metabolism (HP:0010907)2.14710457
84Hydroxyprolinuria (HP:0003080)2.14710457
85Missing ribs (HP:0000921)2.13511583
86Abnormality of the lower motor neuron (HP:0002366)2.12778760
87Neurofibrillary tangles (HP:0002185)2.09086004
88Advanced eruption of teeth (HP:0006288)2.06613712
89Nephrolithiasis (HP:0000787)2.05332928
90Pterygium (HP:0001059)2.03309881
91Bifid scrotum (HP:0000048)2.02748785
92Amelogenesis imperfecta (HP:0000705)2.02625799
93Interstitial pulmonary disease (HP:0006530)2.00285550
94Hypomagnesemia (HP:0002917)2.00101746
95Rickets (HP:0002748)1.99133460
96Lymphangioma (HP:0100764)1.98390889
97Milia (HP:0001056)1.95535945
98Hepatoblastoma (HP:0002884)1.94307036
99Concave nail (HP:0001598)1.93547716
100Hypotrichosis (HP:0001006)1.93016448
101Unilateral renal agenesis (HP:0000122)1.92672462
102Abnormality of the gastric mucosa (HP:0004295)1.92338437
103Status epilepticus (HP:0002133)1.92168321
104Dysmetric saccades (HP:0000641)1.90543689
105Abnormality of the Achilles tendon (HP:0005109)1.89846998
106Abnormality of complement system (HP:0005339)1.89589952
107Enlarged kidneys (HP:0000105)1.89557876
108Steatorrhea (HP:0002570)1.87890226
109Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.87610848
110Hypercholesterolemia (HP:0003124)1.87436778
111Megalencephaly (HP:0001355)1.86542825
112Dehydration (HP:0001944)1.85107904
113Conjugated hyperbilirubinemia (HP:0002908)1.85011069
114Tachypnea (HP:0002789)1.83049010
115Late onset (HP:0003584)1.82707031
116Tibial bowing (HP:0002982)1.82642543
117Hypoglycemic coma (HP:0001325)1.82495404
118Myokymia (HP:0002411)1.82050836
119Abnormality of fatty-acid metabolism (HP:0004359)1.81909590
120Bicornuate uterus (HP:0000813)1.80731649
121Metabolic acidosis (HP:0001942)1.79554151
122Spinal cord compression (HP:0002176)1.79553933
123Vertebral hypoplasia (HP:0008417)1.78848740
124Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.78848740
125Progressive sensorineural hearing impairment (HP:0000408)1.77615396
126Urethral obstruction (HP:0000796)1.77370573
127Irritability (HP:0000737)1.75651333
128Confusion (HP:0001289)1.75321228
129Onycholysis (HP:0001806)1.74401241
130Selective tooth agenesis (HP:0001592)1.74347831
131Visceral angiomatosis (HP:0100761)1.73608181
132Abnormality of the lacrimal duct (HP:0011481)1.72710083
133Abnormality of the intrinsic pathway (HP:0010989)1.72613940
134Proximal tubulopathy (HP:0000114)1.72412245
135Hypotension (HP:0002615)1.72245301
136Partial duplication of thumb phalanx (HP:0009944)1.71573405
137Vertebral arch anomaly (HP:0008438)1.71472319
138Abnormal hair laboratory examination (HP:0003328)1.71203360
139Abnormality of the salivary glands (HP:0010286)1.69627067
140Nasolacrimal duct obstruction (HP:0000579)1.68506404
141Abnormality of magnesium homeostasis (HP:0004921)1.67952560
142Joint hemorrhage (HP:0005261)1.67893102
143Bowing of the arm (HP:0006488)1.67359576
144Bowed forearm bones (HP:0003956)1.67359576
145Curly hair (HP:0002212)1.66680834
146Hypercalciuria (HP:0002150)1.65719840
147Pseudobulbar signs (HP:0002200)1.65548413
148Mitral stenosis (HP:0001718)1.64709413
149Coronal craniosynostosis (HP:0004440)1.64403874
150Shallow orbits (HP:0000586)1.63556837
151Renal tubular acidosis (HP:0001947)1.62596459
152Overriding aorta (HP:0002623)1.62520771
153Chronic bronchitis (HP:0004469)1.62189903
154Hyperparathyroidism (HP:0000843)1.62108326
155Sparse lateral eyebrow (HP:0005338)1.61713961
156Testicular atrophy (HP:0000029)1.60257148
157Facial cleft (HP:0002006)1.59579047
158Esophageal atresia (HP:0002032)1.59056484
159Germ cell neoplasia (HP:0100728)1.58670199
160Fibular aplasia (HP:0002990)1.58622670
161Elfin facies (HP:0004428)1.58572357
162Oligodontia (HP:0000677)1.57661987
163Sparse eyelashes (HP:0000653)1.57366379
164Hypoplastic labia majora (HP:0000059)1.56748870
165Abdominal distention (HP:0003270)1.54232663
166Fragile nails (HP:0001808)1.53952560
16711 pairs of ribs (HP:0000878)1.53485604
168Alopecia of scalp (HP:0002293)1.51822478
169Macroorchidism (HP:0000053)1.51179604
170Vertebral clefting (HP:0008428)1.49927702
171Tubular atrophy (HP:0000092)1.49869580
172Abnormality of nail color (HP:0100643)1.49664038
173Progressive hearing impairment (HP:0001730)1.48352105
174Absent eyebrow (HP:0002223)1.47408471
175Microretrognathia (HP:0000308)1.47201975
176Asymmetry of the thorax (HP:0001555)1.46945045
177Deviation of the thumb (HP:0009603)1.46326359
178Micronodular cirrhosis (HP:0001413)1.45811951
179Congenital glaucoma (HP:0001087)1.44521178
180Broad nasal tip (HP:0000455)1.43970538
181Obstructive sleep apnea (HP:0002870)1.43968294

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA22.62456206
2MAP3K92.60199117
3TRIB32.48968311
4DAPK22.46627446
5EPHA42.44912011
6SIK12.31824957
7WNK32.29657351
8LATS12.23293782
9WNK42.16412238
10CDK122.14540900
11RIPK12.09102699
12LMTK22.07402665
13TSSK61.98095706
14OXSR11.87218244
15CAMK1D1.87174358
16IRAK31.85929574
17MAP3K21.83093790
18SMG11.79509218
19FER1.78664574
20BCKDK1.77375187
21KSR21.76755682
22LATS21.75299681
23MARK11.67305496
24DDR21.65338761
25ERN11.64709947
26FGFR41.62156199
27PKN21.60582390
28NTRK11.60062637
29PTK21.54678268
30FGFR21.53000107
31PTK61.52854420
32TYRO31.51846119
33MST1R1.47213767
34STK381.38103648
35RPS6KB21.37594251
36PAK61.37382518
37PRKD31.35541044
38MAP3K121.35112218
39EPHB21.31292768
40PDGFRA1.30421623
41ERBB41.29970629
42MAP2K41.27874985
43MST41.27547648
44FRK1.26508825
45MAPK151.25434125
46PAK31.18979013
47STK38L1.17729555
48MINK11.17608423
49CAMKK11.17603476
50NTRK31.14426007
51ERBB21.13173700
52BMX1.10591530
53KSR11.07571212
54TAOK11.03165573
55NEK11.02572048
56NEK61.01229579
57MAP3K70.99900484
58NTRK20.98919557
59SGK30.98445523
60LRRK20.98218092
61ICK0.96937858
62CASK0.96596700
63NME10.94221116
64MAP3K40.93990624
65PAK40.93843691
66PIM20.93428397
67RET0.92191367
68MET0.90933488
69MAPKAPK30.89687950
70MAP2K10.88840858
71ARAF0.88370609
72TESK10.87477440
73SGK2230.87349143
74SGK4940.87349143
75DAPK10.86899819
76STK390.86644570
77CAMK2B0.82573000
78EIF2AK10.79577556
79MAP2K20.76647440
80PBK0.76494965
81DYRK1B0.75192472
82FGFR10.74559218
83PRKCI0.73698144
84GSK3A0.72205984
85WEE10.69100296
86EPHB10.68204812
87SGK20.66650180
88MAP3K30.66342996
89DMPK0.65769522
90CDK50.65139346
91NME20.64516009
92CDK80.64385691
93ILK0.63759095
94CAMK2D0.59682595
95TTK0.59300355
96MTOR0.58837704
97IRAK20.58103990
98BRSK10.57933325
99CDK60.57013222
100* PRKCZ0.54107299
101GRK60.54097275
102PDGFRB0.53745111
103AKT30.51847434
104CAMK1G0.51612870
105PDPK10.51500486
106PAK20.50456044
107ALK0.50419866
108STK110.50286408
109PHKG20.49025197
110PHKG10.49025197
111CSNK1G20.48889160
112ROCK10.48834035
113MARK20.48750370
114PRKD20.47690602
115AKT20.47579093
116PRKCG0.46094853
117MATK0.45976210
118IRAK10.45532052
119CDK70.43408925
120SGK10.43248801
121MAP3K10.39689736
122RPS6KA20.39200410
123MAP3K100.38485926
124PRKG20.38288930
125CSNK1E0.37657458
126PNCK0.36583612
127EEF2K0.36540658
128EGFR0.36300260
129SCYL20.36233112
130STK30.35290901
131PRKCH0.34359483
132PRKAA10.34001058
133CAMK2G0.33652613
134FGFR30.33529244
135MELK0.33297362
136EPHA30.32995497
137MUSK0.32570793
138PIK3CA0.31257352
139* AURKB0.29614284
140BRAF0.28812640
141BCR0.28239741
142TAF10.27900580
143BRSK20.27813652
144CDK90.23328888

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.19113732
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.07184746
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.87876003
4Arginine biosynthesis_Homo sapiens_hsa002202.65318322
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.65124440
6Vitamin B6 metabolism_Homo sapiens_hsa007502.35481800
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.34575563
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.24111354
9Tryptophan metabolism_Homo sapiens_hsa003802.19524960
10Butanoate metabolism_Homo sapiens_hsa006502.18143471
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.14439053
12Bile secretion_Homo sapiens_hsa049762.14191416
13Fatty acid degradation_Homo sapiens_hsa000712.11571612
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.97621250
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.79678180
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.79360734
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.76083648
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69443349
19Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.67259232
20PPAR signaling pathway_Homo sapiens_hsa033201.65206521
21Fatty acid metabolism_Homo sapiens_hsa012121.59483176
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.58872066
23Propanoate metabolism_Homo sapiens_hsa006401.53134247
24Complement and coagulation cascades_Homo sapiens_hsa046101.49391861
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.44366357
26Histidine metabolism_Homo sapiens_hsa003401.44172381
27Peroxisome_Homo sapiens_hsa041461.43748166
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.41579049
29Chemical carcinogenesis_Homo sapiens_hsa052041.41277420
30Thyroid cancer_Homo sapiens_hsa052161.39776259
31beta-Alanine metabolism_Homo sapiens_hsa004101.36251844
32Fat digestion and absorption_Homo sapiens_hsa049751.25969319
33Notch signaling pathway_Homo sapiens_hsa043301.21034932
34Pyruvate metabolism_Homo sapiens_hsa006201.17940548
35Sulfur metabolism_Homo sapiens_hsa009201.13623263
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.10173280
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08944018
38Selenocompound metabolism_Homo sapiens_hsa004501.07384249
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.05005510
40Phenylalanine metabolism_Homo sapiens_hsa003601.04303438
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.01802731
42Biosynthesis of amino acids_Homo sapiens_hsa012301.01768226
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00042576
44Retinol metabolism_Homo sapiens_hsa008300.99844077
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99822963
46Vitamin digestion and absorption_Homo sapiens_hsa049770.99089325
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99087067
48Starch and sucrose metabolism_Homo sapiens_hsa005000.98983599
49Caffeine metabolism_Homo sapiens_hsa002320.98813730
50Fatty acid biosynthesis_Homo sapiens_hsa000610.94179371
51Carbon metabolism_Homo sapiens_hsa012000.92512834
52ErbB signaling pathway_Homo sapiens_hsa040120.88919530
53Mineral absorption_Homo sapiens_hsa049780.88295650
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87331564
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86605560
56Glycerolipid metabolism_Homo sapiens_hsa005610.85446547
57Lysine degradation_Homo sapiens_hsa003100.85230324
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.84060904
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83689544
60Arginine and proline metabolism_Homo sapiens_hsa003300.83041941
61Tyrosine metabolism_Homo sapiens_hsa003500.82492591
62Hedgehog signaling pathway_Homo sapiens_hsa043400.79081724
63Gastric acid secretion_Homo sapiens_hsa049710.77956109
64Sphingolipid metabolism_Homo sapiens_hsa006000.76807380
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74770437
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.74020394
67Galactose metabolism_Homo sapiens_hsa000520.72364028
68ABC transporters_Homo sapiens_hsa020100.72088357
69Bladder cancer_Homo sapiens_hsa052190.68552361
70Renal cell carcinoma_Homo sapiens_hsa052110.68157635
71Protein digestion and absorption_Homo sapiens_hsa049740.67632755
72Small cell lung cancer_Homo sapiens_hsa052220.66248373
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.65392566
74Proteoglycans in cancer_Homo sapiens_hsa052050.64641069
75Glutathione metabolism_Homo sapiens_hsa004800.64412465
76Wnt signaling pathway_Homo sapiens_hsa043100.64196509
77Vibrio cholerae infection_Homo sapiens_hsa051100.64167408
78Thyroid hormone synthesis_Homo sapiens_hsa049180.64156733
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63314679
80Insulin signaling pathway_Homo sapiens_hsa049100.62288544
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60762393
82Focal adhesion_Homo sapiens_hsa045100.60413896
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59427199
84Circadian rhythm_Homo sapiens_hsa047100.58829867
85Prostate cancer_Homo sapiens_hsa052150.57636652
86Salivary secretion_Homo sapiens_hsa049700.57367234
87Tight junction_Homo sapiens_hsa045300.57228111
88Steroid biosynthesis_Homo sapiens_hsa001000.57049939
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55084248
90TGF-beta signaling pathway_Homo sapiens_hsa043500.54407818
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53023540
92MicroRNAs in cancer_Homo sapiens_hsa052060.52154223
93N-Glycan biosynthesis_Homo sapiens_hsa005100.51885568
94Cocaine addiction_Homo sapiens_hsa050300.51161380
95Synaptic vesicle cycle_Homo sapiens_hsa047210.50301337
96Ovarian steroidogenesis_Homo sapiens_hsa049130.50299096
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48172063
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47060739
99Pancreatic secretion_Homo sapiens_hsa049720.46480885
100GABAergic synapse_Homo sapiens_hsa047270.46279703
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45087048
102Adherens junction_Homo sapiens_hsa045200.44904824
103Nicotine addiction_Homo sapiens_hsa050330.44427710
104Chronic myeloid leukemia_Homo sapiens_hsa052200.43670351
105Choline metabolism in cancer_Homo sapiens_hsa052310.43615936
106* Hippo signaling pathway_Homo sapiens_hsa043900.42356592
107Endometrial cancer_Homo sapiens_hsa052130.42032365
108Prion diseases_Homo sapiens_hsa050200.40413285
109Folate biosynthesis_Homo sapiens_hsa007900.38538177
110Insulin resistance_Homo sapiens_hsa049310.35668869
111Fatty acid elongation_Homo sapiens_hsa000620.34732746
112Glioma_Homo sapiens_hsa052140.33998400
113Insulin secretion_Homo sapiens_hsa049110.33864521
114Staphylococcus aureus infection_Homo sapiens_hsa051500.31928970
115Glucagon signaling pathway_Homo sapiens_hsa049220.31274337
116Aldosterone synthesis and secretion_Homo sapiens_hsa049250.29593318
117Melanogenesis_Homo sapiens_hsa049160.28797878
118Dorso-ventral axis formation_Homo sapiens_hsa043200.28793830
119Axon guidance_Homo sapiens_hsa043600.28646812
120Glutamatergic synapse_Homo sapiens_hsa047240.28414731
121Fructose and mannose metabolism_Homo sapiens_hsa000510.28272795
122Renin-angiotensin system_Homo sapiens_hsa046140.28072318
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.27672689
124Long-term potentiation_Homo sapiens_hsa047200.27592811
125AMPK signaling pathway_Homo sapiens_hsa041520.27544382
126Gap junction_Homo sapiens_hsa045400.25488911
127Sulfur relay system_Homo sapiens_hsa041220.25180279
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.24941927
129Estrogen signaling pathway_Homo sapiens_hsa049150.24915940
130Basal cell carcinoma_Homo sapiens_hsa052170.24265547
131Olfactory transduction_Homo sapiens_hsa047400.23448722
132ECM-receptor interaction_Homo sapiens_hsa045120.23126520
133Renin secretion_Homo sapiens_hsa049240.22519652

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