Rank | Gene Set | Z-score |
---|---|---|
1 | desmosome organization (GO:0002934) | 5.38598268 |
2 | cysteine metabolic process (GO:0006534) | 5.15081303 |
3 | L-phenylalanine catabolic process (GO:0006559) | 4.80103888 |
4 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 4.80103888 |
5 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 4.73118677 |
6 | L-phenylalanine metabolic process (GO:0006558) | 4.73118677 |
7 | lysine metabolic process (GO:0006553) | 4.53027489 |
8 | lysine catabolic process (GO:0006554) | 4.53027489 |
9 | aromatic amino acid family catabolic process (GO:0009074) | 4.35149971 |
10 | alpha-linolenic acid metabolic process (GO:0036109) | 4.32805149 |
11 | sulfur amino acid catabolic process (GO:0000098) | 4.28060401 |
12 | glyoxylate metabolic process (GO:0046487) | 4.13248645 |
13 | apical protein localization (GO:0045176) | 4.12687214 |
14 | kynurenine metabolic process (GO:0070189) | 4.07027007 |
15 | glutamate metabolic process (GO:0006536) | 4.02053747 |
16 | drug catabolic process (GO:0042737) | 3.97804569 |
17 | asymmetric protein localization (GO:0008105) | 3.97216983 |
18 | tryptophan catabolic process (GO:0006569) | 3.96701424 |
19 | indole-containing compound catabolic process (GO:0042436) | 3.96701424 |
20 | indolalkylamine catabolic process (GO:0046218) | 3.96701424 |
21 | homocysteine metabolic process (GO:0050667) | 3.96485482 |
22 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 3.94787999 |
23 | regulation of cholesterol homeostasis (GO:2000188) | 3.85283915 |
24 | cellular modified amino acid catabolic process (GO:0042219) | 3.82148775 |
25 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 3.78604815 |
26 | phosphate ion transmembrane transport (GO:0035435) | 3.77876885 |
27 | branching involved in salivary gland morphogenesis (GO:0060445) | 3.76166305 |
28 | bile acid biosynthetic process (GO:0006699) | 3.75635877 |
29 | tryptophan metabolic process (GO:0006568) | 3.72639382 |
30 | serine family amino acid catabolic process (GO:0009071) | 3.69230339 |
31 | phosphate ion transport (GO:0006817) | 3.68876643 |
32 | regulation of water loss via skin (GO:0033561) | 3.62309437 |
33 | urea cycle (GO:0000050) | 3.58595841 |
34 | urea metabolic process (GO:0019627) | 3.58595841 |
35 | amino-acid betaine metabolic process (GO:0006577) | 3.55941009 |
36 | notochord development (GO:0030903) | 3.55284963 |
37 | exogenous drug catabolic process (GO:0042738) | 3.53266665 |
38 | urate metabolic process (GO:0046415) | 3.51703886 |
39 | cellular ketone body metabolic process (GO:0046950) | 3.45422668 |
40 | drug transmembrane transport (GO:0006855) | 3.42045055 |
41 | dicarboxylic acid biosynthetic process (GO:0043650) | 3.41268734 |
42 | aspartate family amino acid catabolic process (GO:0009068) | 3.39708908 |
43 | establishment of apical/basal cell polarity (GO:0035089) | 3.38509674 |
44 | negative regulation of fibrinolysis (GO:0051918) | 3.37798371 |
45 | ethanol oxidation (GO:0006069) | 3.37105037 |
46 | negative regulation of cholesterol transport (GO:0032375) | 3.35671175 |
47 | negative regulation of sterol transport (GO:0032372) | 3.35671175 |
48 | hemidesmosome assembly (GO:0031581) | 3.31656065 |
49 | epithelial cell-cell adhesion (GO:0090136) | 3.30846972 |
50 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 3.27886493 |
51 | tight junction assembly (GO:0070830) | 3.27744886 |
52 | high-density lipoprotein particle remodeling (GO:0034375) | 3.25425991 |
53 | pattern specification involved in kidney development (GO:0061004) | 3.25248421 |
54 | nitrogen cycle metabolic process (GO:0071941) | 3.25049926 |
55 | alpha-amino acid catabolic process (GO:1901606) | 3.23843795 |
56 | activation of Rac GTPase activity (GO:0032863) | 3.23561810 |
57 | bile acid metabolic process (GO:0008206) | 3.22335710 |
58 | establishment of skin barrier (GO:0061436) | 3.20156770 |
59 | serine family amino acid metabolic process (GO:0009069) | 3.19513805 |
60 | cellular amino acid catabolic process (GO:0009063) | 3.17139215 |
61 | multicellular organismal water homeostasis (GO:0050891) | 3.14898052 |
62 | short-chain fatty acid metabolic process (GO:0046459) | 3.14515656 |
63 | reverse cholesterol transport (GO:0043691) | 3.13313553 |
64 | intestinal epithelial cell development (GO:0060576) | 3.10854343 |
65 | aromatic amino acid family metabolic process (GO:0009072) | 3.08766294 |
66 | protein carboxylation (GO:0018214) | 3.06323668 |
67 | peptidyl-glutamic acid carboxylation (GO:0017187) | 3.06323668 |
68 | intestinal cholesterol absorption (GO:0030299) | 3.05639284 |
69 | regulation of protein activation cascade (GO:2000257) | 3.05067373 |
70 | regulation of bile acid biosynthetic process (GO:0070857) | 2.99143421 |
71 | complement activation, alternative pathway (GO:0006957) | 2.98980152 |
72 | surfactant homeostasis (GO:0043129) | 2.97989194 |
73 | flavonoid metabolic process (GO:0009812) | 2.97016922 |
74 | gap junction assembly (GO:0016264) | 2.96638020 |
75 | biotin metabolic process (GO:0006768) | 2.95338763 |
76 | regulation of fibrinolysis (GO:0051917) | 2.94908155 |
77 | endothelial cell chemotaxis (GO:0035767) | 2.94043924 |
78 | lung epithelium development (GO:0060428) | 2.93315797 |
79 | ketone body metabolic process (GO:1902224) | 2.93116319 |
80 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 2.92329951 |
81 | response to mercury ion (GO:0046689) | 2.91871889 |
82 | regulation of complement activation (GO:0030449) | 2.88385182 |
83 | drug transport (GO:0015893) | 2.87317569 |
84 | regulation of vascular endothelial growth factor signaling pathway (GO:1900746) | 2.86926936 |
85 | response to nitrosative stress (GO:0051409) | 2.85765049 |
86 | midgut development (GO:0007494) | 2.84371078 |
87 | serine family amino acid biosynthetic process (GO:0009070) | 2.81609748 |
88 | acetyl-CoA metabolic process (GO:0006084) | 2.81572506 |
89 | cellular glucuronidation (GO:0052695) | 2.79474321 |
90 | benzene-containing compound metabolic process (GO:0042537) | 2.78935492 |
91 | cell-cell junction assembly (GO:0007043) | 2.78005803 |
92 | nephron tubule formation (GO:0072079) | 2.77728033 |
93 | hormone catabolic process (GO:0042447) | 2.77709565 |
94 | pyrimidine nucleobase catabolic process (GO:0006208) | 2.76477375 |
95 | establishment of monopolar cell polarity (GO:0061162) | 2.75979219 |
96 | establishment or maintenance of monopolar cell polarity (GO:0061339) | 2.75979219 |
97 | protein-lipid complex remodeling (GO:0034368) | 2.75637289 |
98 | macromolecular complex remodeling (GO:0034367) | 2.75637289 |
99 | plasma lipoprotein particle remodeling (GO:0034369) | 2.75637289 |
100 | establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197) | 2.75023590 |
101 | 2-oxoglutarate metabolic process (GO:0006103) | 2.74255741 |
102 | negative regulation of keratinocyte proliferation (GO:0010839) | 2.73971669 |
103 | myelin maintenance (GO:0043217) | 2.73945611 |
104 | embryonic retina morphogenesis in camera-type eye (GO:0060059) | 2.73817029 |
105 | coenzyme catabolic process (GO:0009109) | 2.72571161 |
106 | tyrosine metabolic process (GO:0006570) | 2.71969740 |
107 | regulation of cholesterol esterification (GO:0010872) | 2.69900062 |
108 | establishment or maintenance of bipolar cell polarity (GO:0061245) | 2.68818486 |
109 | establishment or maintenance of apical/basal cell polarity (GO:0035088) | 2.68818486 |
110 | chemical homeostasis within a tissue (GO:0048875) | 2.68351907 |
111 | regulation of triglyceride catabolic process (GO:0010896) | 2.66824418 |
112 | epoxygenase P450 pathway (GO:0019373) | 2.64722839 |
113 | paraxial mesoderm development (GO:0048339) | 2.64402162 |
114 | organic acid catabolic process (GO:0016054) | 2.64396536 |
115 | carboxylic acid catabolic process (GO:0046395) | 2.64396536 |
116 | indolalkylamine metabolic process (GO:0006586) | 2.64285786 |
117 | regulation of cholesterol biosynthetic process (GO:0045540) | 2.64153996 |
118 | water homeostasis (GO:0030104) | 2.63998859 |
119 | regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) | 2.63687939 |
120 | drug metabolic process (GO:0017144) | 2.63393897 |
121 | carnitine metabolic process (GO:0009437) | 2.63305186 |
122 | dicarboxylic acid catabolic process (GO:0043649) | 2.62095653 |
123 | triglyceride homeostasis (GO:0070328) | 2.61882452 |
124 | acylglycerol homeostasis (GO:0055090) | 2.61882452 |
125 | nucleobase catabolic process (GO:0046113) | 2.61849956 |
126 | L-ascorbic acid metabolic process (GO:0019852) | 2.58022589 |
127 | bile acid and bile salt transport (GO:0015721) | 2.57233172 |
128 | phospholipid homeostasis (GO:0055091) | 2.56981205 |
129 | glycine metabolic process (GO:0006544) | 2.56497782 |
130 | polarized epithelial cell differentiation (GO:0030859) | 2.56184541 |
131 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 2.55664813 |
132 | ear development (GO:0043583) | 2.55236974 |
133 | layer formation in cerebral cortex (GO:0021819) | 2.54810938 |
134 | auditory receptor cell differentiation (GO:0042491) | 2.54582871 |
135 | arginine metabolic process (GO:0006525) | 2.54293640 |
136 | phospholipid efflux (GO:0033700) | 2.53281523 |
137 | ethanol metabolic process (GO:0006067) | 2.52685463 |
138 | COPI coating of Golgi vesicle (GO:0048205) | 2.52044523 |
139 | Golgi transport vesicle coating (GO:0048200) | 2.52044523 |
140 | Wnt signaling pathway, planar cell polarity pathway (GO:0060071) | 2.50670801 |
141 | regulation of Wnt signaling pathway involved in heart development (GO:0003307) | 2.49192428 |
142 | cell-cell junction maintenance (GO:0045217) | 2.48724643 |
143 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338) | 2.42397301 |
144 | regulation of cell proliferation involved in kidney development (GO:1901722) | 2.40912284 |
145 | protein localization to microtubule (GO:0035372) | 2.40551507 |
146 | protein autoprocessing (GO:0016540) | 2.38145247 |
147 | regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547) | 2.38102486 |
148 | semaphorin-plexin signaling pathway (GO:0071526) | 2.36891263 |
149 | regulation of establishment of planar polarity (GO:0090175) | 2.35047801 |
150 | dichotomous subdivision of an epithelial terminal unit (GO:0060600) | 2.33953167 |
151 | establishment of planar polarity (GO:0001736) | 2.33672820 |
152 | establishment of tissue polarity (GO:0007164) | 2.33672820 |
153 | axon ensheathment in central nervous system (GO:0032291) | 2.31593832 |
154 | central nervous system myelination (GO:0022010) | 2.31593832 |
155 | regulation of apoptotic process involved in morphogenesis (GO:1902337) | 2.29992202 |
156 | regulation of branching involved in prostate gland morphogenesis (GO:0060687) | 2.28682917 |
157 | * hippo signaling (GO:0035329) | 2.28483488 |
158 | epithelial tube branching involved in lung morphogenesis (GO:0060441) | 2.28083230 |
159 | ectoderm development (GO:0007398) | 2.27779251 |
160 | branching involved in mammary gland duct morphogenesis (GO:0060444) | 2.27440900 |
161 | adherens junction assembly (GO:0034333) | 2.26066105 |
162 | regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307) | 2.24851190 |
163 | positive regulation of epidermal cell differentiation (GO:0045606) | 2.24330613 |
164 | mating behavior (GO:0007617) | 2.22707446 |
165 | primary alcohol catabolic process (GO:0034310) | 2.21681766 |
166 | morphogenesis of embryonic epithelium (GO:0016331) | 2.21279417 |
167 | atrioventricular valve morphogenesis (GO:0003181) | 2.20252229 |
168 | negative regulation of cell fate specification (GO:0009996) | 2.19463022 |
169 | retrograde vesicle-mediated transport, Golgi to ER (GO:0006890) | 2.19333744 |
170 | cell-substrate adherens junction assembly (GO:0007045) | 2.18308919 |
171 | focal adhesion assembly (GO:0048041) | 2.18308919 |
172 | non-canonical Wnt signaling pathway (GO:0035567) | 2.17770104 |
173 | positive regulation of keratinocyte differentiation (GO:0045618) | 2.17698878 |
174 | positive regulation of establishment of protein localization to plasma membrane (GO:0090004) | 2.14178875 |
175 | negative regulation of mesenchymal cell apoptotic process (GO:2001054) | 2.13907284 |
176 | cell junction maintenance (GO:0034331) | 2.12230124 |
177 | glomerular epithelial cell development (GO:0072310) | 2.10050375 |
178 | metanephric nephron epithelium development (GO:0072243) | 2.10029059 |
179 | regulation of mesenchymal cell apoptotic process (GO:2001053) | 2.08720616 |
180 | regulation of endothelial cell chemotaxis (GO:2001026) | 2.07892714 |
181 | cell-substrate junction assembly (GO:0007044) | 2.07711391 |
182 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 2.07705408 |
183 | camera-type eye morphogenesis (GO:0048593) | 2.07038516 |
184 | lateral sprouting from an epithelium (GO:0060601) | 2.06759740 |
185 | collecting duct development (GO:0072044) | 2.05958077 |
186 | regulation of nephron tubule epithelial cell differentiation (GO:0072182) | 2.05869693 |
187 | ER overload response (GO:0006983) | 2.04876427 |
188 | cell-cell junction organization (GO:0045216) | 2.04596698 |
189 | iron ion import (GO:0097286) | 2.02726122 |
190 | negative regulation of cell fate commitment (GO:0010454) | 2.02352781 |
191 | embryonic eye morphogenesis (GO:0048048) | 2.02272996 |
192 | cell junction assembly (GO:0034329) | 2.01949200 |
193 | sodium ion export (GO:0071436) | 2.01838516 |
Rank | Gene Set | Z-score |
---|---|---|
1 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 5.66330589 |
2 | * RXR_22158963_ChIP-Seq_LIVER_Mouse | 4.13780608 |
3 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 3.59993318 |
4 | * LXR_22158963_ChIP-Seq_LIVER_Mouse | 3.49440687 |
5 | * NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 2.62681860 |
6 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 2.61463354 |
7 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 2.54270088 |
8 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 2.51491321 |
9 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.29381383 |
10 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 2.27883279 |
11 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 2.23053197 |
12 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 2.22302817 |
13 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.99541750 |
14 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.96515128 |
15 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.93889559 |
16 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.88134044 |
17 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.86408074 |
18 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.86340059 |
19 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.83430854 |
20 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.82921056 |
21 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.74813023 |
22 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 1.60869484 |
23 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.56988026 |
24 | * SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.56577127 |
25 | * SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.56577127 |
26 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.56311629 |
27 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.54284623 |
28 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.52810083 |
29 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.51781715 |
30 | * ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.51594742 |
31 | ATF3_27146783_Chip-Seq_COLON_Human | 1.50651376 |
32 | GATA3_24758297_ChIP-Seq_MCF-7_Human | 1.49110897 |
33 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.48374998 |
34 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 1.46475282 |
35 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.45981545 |
36 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.43957005 |
37 | * KLF5_25053715_ChIP-Seq_YYC3_Human | 1.40585696 |
38 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.40473202 |
39 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 1.40203474 |
40 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.35529778 |
41 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.34518553 |
42 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.34448952 |
43 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.33854673 |
44 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.31228007 |
45 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.30358244 |
46 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 1.29668707 |
47 | CHD1_26751641_Chip-Seq_LNCaP_Human | 1.25720382 |
48 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 1.25595733 |
49 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 1.25595733 |
50 | KDM2B_26808549_Chip-Seq_K562_Human | 1.24900235 |
51 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.24449614 |
52 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.24203938 |
53 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.24066073 |
54 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.20478846 |
55 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.20423713 |
56 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.19536225 |
57 | * WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.18273525 |
58 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.17775378 |
59 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.16891171 |
60 | * PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.15929693 |
61 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 1.12735515 |
62 | FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 1.12153211 |
63 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.12013107 |
64 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.11273654 |
65 | * EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 1.10225349 |
66 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.09948052 |
67 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 1.08537475 |
68 | * ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.07987765 |
69 | * WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.07811182 |
70 | * GATA4_25053715_ChIP-Seq_YYC3_Human | 1.06933189 |
71 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.06930001 |
72 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.06487653 |
73 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.06482016 |
74 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.06346559 |
75 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.05971544 |
76 | * ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.05821352 |
77 | * RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.04802133 |
78 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.04307021 |
79 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.04125669 |
80 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.03855217 |
81 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 1.03815280 |
82 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 1.02497058 |
83 | * HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.01872648 |
84 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.01431191 |
85 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 1.00792216 |
86 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 1.00784790 |
87 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.00742603 |
88 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.00026749 |
89 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 0.99529349 |
90 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.99411793 |
91 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 0.99261660 |
92 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 0.98551070 |
93 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 0.98208944 |
94 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.97940362 |
95 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.97860239 |
96 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 0.97801731 |
97 | * SOX2_20726797_ChIP-Seq_SW620_Human | 0.97597031 |
98 | FOXA1_25552417_ChIP-Seq_VCAP_Human | 0.96876618 |
99 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.95843122 |
100 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.95393185 |
101 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 0.95309605 |
102 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.94436918 |
103 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.93708932 |
104 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 0.93498314 |
105 | UBF1/2_26484160_Chip-Seq_HMECs_Human | 0.92513548 |
106 | * ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.91820715 |
107 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 0.91088397 |
108 | * KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.90794257 |
109 | * KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.89915354 |
110 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 0.89493813 |
111 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.88179643 |
112 | GATA6_25053715_ChIP-Seq_YYC3_Human | 0.88085231 |
113 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.87703221 |
114 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.87599170 |
115 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 0.87403988 |
116 | * SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.87039704 |
117 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.86711220 |
118 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.86618108 |
119 | TP53_22127205_ChIP-Seq_IMR90_Human | 0.86352570 |
120 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 0.86189339 |
121 | TP63_22573176_ChIP-Seq_HFKS_Human | 0.86182212 |
122 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.86029699 |
123 | * RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 0.85643236 |
124 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.85340612 |
125 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.85018581 |
126 | * CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 0.84923933 |
127 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.84913475 |
128 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.84552220 |
129 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 0.84146812 |
130 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 0.83952695 |
131 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.83903619 |
132 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 0.83743307 |
133 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 0.83115713 |
134 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 0.82522163 |
135 | * SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 0.81893331 |
136 | RXR_22108803_ChIP-Seq_LS180_Human | 0.81877091 |
137 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.81429603 |
138 | * ELF5_23300383_ChIP-Seq_T47D_Human | 0.80736604 |
139 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.80327495 |
140 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 0.80297508 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002139_abnormal_hepatobiliary_system | 6.16566427 |
2 | MP0005360_urolithiasis | 5.97850344 |
3 | MP0005085_abnormal_gallbladder_physiolo | 4.42969537 |
4 | MP0005365_abnormal_bile_salt | 4.06480692 |
5 | MP0008875_abnormal_xenobiotic_pharmacok | 3.69764079 |
6 | MP0010234_abnormal_vibrissa_follicle | 3.44959728 |
7 | MP0003252_abnormal_bile_duct | 3.38449127 |
8 | MP0002138_abnormal_hepatobiliary_system | 2.85277244 |
9 | MP0001666_abnormal_nutrient_absorption | 2.65044842 |
10 | MP0005083_abnormal_biliary_tract | 2.62040112 |
11 | MP0005332_abnormal_amino_acid | 2.60697712 |
12 | MP0010329_abnormal_lipoprotein_level | 2.46788320 |
13 | MP0004019_abnormal_vitamin_homeostasis | 2.41856019 |
14 | MP0000383_abnormal_hair_follicle | 2.29408222 |
15 | MP0003705_abnormal_hypodermis_morpholog | 2.21048757 |
16 | MP0003136_yellow_coat_color | 2.11102094 |
17 | MP0003806_abnormal_nucleotide_metabolis | 2.02930959 |
18 | MP0003195_calcinosis | 1.91370177 |
19 | MP0004859_abnormal_synaptic_plasticity | 1.87980690 |
20 | MP0004858_abnormal_nervous_system | 1.84363755 |
21 | MP0005076_abnormal_cell_differentiation | 1.81400258 |
22 | MP0010352_gastrointestinal_tract_polyps | 1.79225852 |
23 | MP0009780_abnormal_chondrocyte_physiolo | 1.74685925 |
24 | MP0000762_abnormal_tongue_morphology | 1.73970476 |
25 | MP0004885_abnormal_endolymph | 1.70836035 |
26 | MP0004043_abnormal_pH_regulation | 1.66126893 |
27 | MP0003941_abnormal_skin_development | 1.64602285 |
28 | MP0003329_amyloid_beta_deposits | 1.64542525 |
29 | MP0000537_abnormal_urethra_morphology | 1.62795492 |
30 | MP0009840_abnormal_foam_cell | 1.60954112 |
31 | MP0003191_abnormal_cellular_cholesterol | 1.57349333 |
32 | MP0009643_abnormal_urine_homeostasis | 1.53856509 |
33 | MP0004233_abnormal_muscle_weight | 1.49964294 |
34 | MP0002118_abnormal_lipid_homeostasis | 1.49360484 |
35 | MP0004185_abnormal_adipocyte_glucose | 1.47914292 |
36 | MP0002796_impaired_skin_barrier | 1.44175191 |
37 | MP0002254_reproductive_system_inflammat | 1.41633502 |
38 | MP0004264_abnormal_extraembryonic_tissu | 1.38867684 |
39 | MP0003868_abnormal_feces_composition | 1.35849052 |
40 | MP0005167_abnormal_blood-brain_barrier | 1.34133209 |
41 | MP0002697_abnormal_eye_size | 1.33296419 |
42 | MP0001346_abnormal_lacrimal_gland | 1.33243751 |
43 | MP0001756_abnormal_urination | 1.31063355 |
44 | MP0000377_abnormal_hair_follicle | 1.29477177 |
45 | MP0000678_abnormal_parathyroid_gland | 1.28457872 |
46 | MP0010771_integument_phenotype | 1.25811952 |
47 | MP0002249_abnormal_larynx_morphology | 1.25755291 |
48 | MP0001216_abnormal_epidermal_layer | 1.23599937 |
49 | MP0003283_abnormal_digestive_organ | 1.22109837 |
50 | MP0000647_abnormal_sebaceous_gland | 1.21997942 |
51 | MP0005409_darkened_coat_color | 1.21207586 |
52 | MP0001958_emphysema | 1.17926887 |
53 | MP0002877_abnormal_melanocyte_morpholog | 1.17060247 |
54 | MP0001765_abnormal_ion_homeostasis | 1.16557681 |
55 | MP0000609_abnormal_liver_physiology | 1.16390391 |
56 | MP0005084_abnormal_gallbladder_morpholo | 1.15189540 |
57 | MP0000627_abnormal_mammary_gland | 1.15144732 |
58 | MP0008961_abnormal_basal_metabolism | 1.14321594 |
59 | MP0010030_abnormal_orbit_morphology | 1.14013784 |
60 | MP0004782_abnormal_surfactant_physiolog | 1.12366706 |
61 | MP0003300_gastrointestinal_ulcer | 1.11575417 |
62 | MP0005319_abnormal_enzyme/_coenzyme | 1.08407810 |
63 | MP0000604_amyloidosis | 1.07402989 |
64 | MP0001177_atelectasis | 1.07297052 |
65 | MP0009053_abnormal_anal_canal | 1.06368762 |
66 | MP0005248_abnormal_Harderian_gland | 1.04138834 |
67 | MP0002928_abnormal_bile_duct | 1.03100651 |
68 | MP0005257_abnormal_intraocular_pressure | 1.01503766 |
69 | MP0005636_abnormal_mineral_homeostasis | 1.00600401 |
70 | MP0002876_abnormal_thyroid_physiology | 1.00573090 |
71 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.99966827 |
72 | MP0010678_abnormal_skin_adnexa | 0.98946699 |
73 | MP0000427_abnormal_hair_cycle | 0.97990867 |
74 | MP0000534_abnormal_ureter_morphology | 0.96875390 |
75 | MP0009379_abnormal_foot_pigmentation | 0.94666322 |
76 | MP0009672_abnormal_birth_weight | 0.92700697 |
77 | MP0000003_abnormal_adipose_tissue | 0.91746151 |
78 | MP0002136_abnormal_kidney_physiology | 0.91005599 |
79 | MP0003878_abnormal_ear_physiology | 0.90517861 |
80 | MP0005377_hearing/vestibular/ear_phenot | 0.90517861 |
81 | MP0001849_ear_inflammation | 0.90132658 |
82 | MP0004270_analgesia | 0.89023642 |
83 | MP0003755_abnormal_palate_morphology | 0.88531303 |
84 | MP0003075_altered_response_to | 0.88279903 |
85 | MP0005220_abnormal_exocrine_pancreas | 0.88008864 |
86 | MP0002234_abnormal_pharynx_morphology | 0.86240633 |
87 | MP0003937_abnormal_limbs/digits/tail_de | 0.85871089 |
88 | MP0002822_catalepsy | 0.84834718 |
89 | MP0009384_cardiac_valve_regurgitation | 0.84776260 |
90 | MP0002168_other_aberrant_phenotype | 0.84172357 |
91 | MP0003936_abnormal_reproductive_system | 0.83782687 |
92 | MP0003879_abnormal_hair_cell | 0.81775702 |
93 | MP0003635_abnormal_synaptic_transmissio | 0.81231849 |
94 | MP0000613_abnormal_salivary_gland | 0.81126859 |
95 | MP0002084_abnormal_developmental_patter | 0.80809338 |
96 | MP0002653_abnormal_ependyma_morphology | 0.80362263 |
97 | MP0001944_abnormal_pancreas_morphology | 0.80346508 |
98 | MP0002736_abnormal_nociception_after | 0.80227656 |
99 | MP0002060_abnormal_skin_morphology | 0.80133835 |
100 | MP0003183_abnormal_peptide_metabolism | 0.79923504 |
101 | MP0005023_abnormal_wound_healing | 0.79529833 |
102 | MP0002909_abnormal_adrenal_gland | 0.79347644 |
103 | MP0004272_abnormal_basement_membrane | 0.78568706 |
104 | MP0002111_abnormal_tail_morphology | 0.75828805 |
105 | MP0001502_abnormal_circadian_rhythm | 0.75361865 |
106 | MP0000579_abnormal_nail_morphology | 0.75361722 |
107 | MP0000566_synostosis | 0.75142685 |
108 | MP0003315_abnormal_perineum_morphology | 0.74937535 |
109 | MP0005666_abnormal_adipose_tissue | 0.73846477 |
110 | MP0005187_abnormal_penis_morphology | 0.73830590 |
111 | MP0002063_abnormal_learning/memory/cond | 0.73155868 |
112 | MP0003938_abnormal_ear_development | 0.72702308 |
113 | MP0003861_abnormal_nervous_system | 0.72234799 |
114 | MP0003115_abnormal_respiratory_system | 0.72234529 |
115 | MP0003638_abnormal_response/metabolism_ | 0.70838143 |
116 | MP0003690_abnormal_glial_cell | 0.70505759 |
117 | MP0008004_abnormal_stomach_pH | 0.69700803 |
118 | MP0002085_abnormal_embryonic_tissue | 0.69693087 |
119 | MP0003943_abnormal_hepatobiliary_system | 0.69549048 |
120 | MP0001881_abnormal_mammary_gland | 0.69025700 |
121 | MP0003119_abnormal_digestive_system | 0.68745805 |
122 | MP0002092_abnormal_eye_morphology | 0.68600334 |
123 | MP0001286_abnormal_eye_development | 0.68225293 |
124 | MP0001340_abnormal_eyelid_morphology | 0.67833517 |
125 | MP0005623_abnormal_meninges_morphology | 0.67304746 |
126 | MP0000432_abnormal_head_morphology | 0.67053945 |
127 | MP0010368_abnormal_lymphatic_system | 0.66672281 |
128 | MP0003693_abnormal_embryo_hatching | 0.66650134 |
129 | MP0000462_abnormal_digestive_system | 0.66274517 |
130 | MP0005375_adipose_tissue_phenotype | 0.66093032 |
131 | MP0008872_abnormal_physiological_respon | 0.65635007 |
132 | MP0005501_abnormal_skin_physiology | 0.65470228 |
133 | MP0004130_abnormal_muscle_cell | 0.63828723 |
134 | MP0002295_abnormal_pulmonary_circulatio | 0.62866440 |
135 | MP0000538_abnormal_urinary_bladder | 0.62641570 |
136 | MP0004133_heterotaxia | 0.61814089 |
137 | MP0002896_abnormal_bone_mineralization | 0.61086635 |
138 | MP0002089_abnormal_postnatal_growth/wei | 0.59474501 |
139 | MP0003453_abnormal_keratinocyte_physiol | 0.59372896 |
140 | MP0000778_abnormal_nervous_system | 0.58660388 |
141 | MP0001664_abnormal_digestion | 0.57809150 |
142 | MP0003942_abnormal_urinary_system | 0.57606668 |
143 | MP0005166_decreased_susceptibility_to | 0.57584419 |
144 | MP0001485_abnormal_pinna_reflex | 0.57260432 |
145 | MP0002098_abnormal_vibrissa_morphology | 0.55474633 |
146 | MP0000467_abnormal_esophagus_morphology | 0.53703032 |
147 | MP0000598_abnormal_liver_morphology | 0.52598393 |
148 | MP0009745_abnormal_behavioral_response | 0.51601593 |
149 | MP0003632_abnormal_nervous_system | 0.50942344 |
150 | MP0003566_abnormal_cell_adhesion | 0.50518347 |
151 | MP0002069_abnormal_eating/drinking_beha | 0.48997695 |
152 | MP0001440_abnormal_grooming_behavior | 0.47680766 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Gout (HP:0001997) | 5.31819797 |
2 | Deep venous thrombosis (HP:0002625) | 4.72597112 |
3 | Intrahepatic cholestasis (HP:0001406) | 4.34169540 |
4 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 4.22983318 |
5 | Hyperactive renin-angiotensin system (HP:0000841) | 4.17860507 |
6 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 3.99877127 |
7 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 3.90735250 |
8 | Xanthomatosis (HP:0000991) | 3.84335092 |
9 | Hyperglycinuria (HP:0003108) | 3.68786949 |
10 | Hypokalemic alkalosis (HP:0001949) | 3.47089780 |
11 | Hypobetalipoproteinemia (HP:0003563) | 3.35030794 |
12 | Abnormality of glycine metabolism (HP:0010895) | 3.33801390 |
13 | Abnormality of serine family amino acid metabolism (HP:0010894) | 3.33801390 |
14 | Renal salt wasting (HP:0000127) | 3.28258733 |
15 | Hyperglycinemia (HP:0002154) | 3.15861856 |
16 | Hyperuricemia (HP:0002149) | 3.13644999 |
17 | Increased purine levels (HP:0004368) | 3.13644999 |
18 | Abnormality of chloride homeostasis (HP:0011422) | 3.10127690 |
19 | Abnormality of purine metabolism (HP:0004352) | 3.09843030 |
20 | Ketosis (HP:0001946) | 3.09340069 |
21 | Potter facies (HP:0002009) | 3.07214612 |
22 | Facial shape deformation (HP:0011334) | 3.07214612 |
23 | Metabolic alkalosis (HP:0200114) | 3.06074178 |
24 | Increased circulating renin level (HP:0000848) | 3.02417415 |
25 | Hyperammonemia (HP:0001987) | 2.95517769 |
26 | Broad face (HP:0000283) | 2.93337246 |
27 | Delayed CNS myelination (HP:0002188) | 2.88976970 |
28 | Ketoacidosis (HP:0001993) | 2.88945124 |
29 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 2.87251545 |
30 | Alkalosis (HP:0001948) | 2.86035676 |
31 | Complement deficiency (HP:0004431) | 2.85235785 |
32 | Spastic diplegia (HP:0001264) | 2.78511853 |
33 | Hyperacusis (HP:0010780) | 2.75785859 |
34 | Esophageal varix (HP:0002040) | 2.75264668 |
35 | Hyperlipoproteinemia (HP:0010980) | 2.73867098 |
36 | Epidermoid cyst (HP:0200040) | 2.71630932 |
37 | Glomerulosclerosis (HP:0000096) | 2.68896871 |
38 | Vascular calcification (HP:0004934) | 2.68059963 |
39 | Malnutrition (HP:0004395) | 2.67427298 |
40 | Hyperaldosteronism (HP:0000859) | 2.65454542 |
41 | Fat malabsorption (HP:0002630) | 2.62754686 |
42 | Pili torti (HP:0003777) | 2.61165304 |
43 | Abnormality of renal excretion (HP:0011036) | 2.60245987 |
44 | Short nail (HP:0001799) | 2.60099641 |
45 | Hypolipoproteinemia (HP:0010981) | 2.59584531 |
46 | Abnormality of permanent molar morphology (HP:0011071) | 2.56604146 |
47 | Abnormality of the dental root (HP:0006486) | 2.56604146 |
48 | Taurodontia (HP:0000679) | 2.56604146 |
49 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.55443296 |
50 | Turricephaly (HP:0000262) | 2.54309389 |
51 | Tubulointerstitial fibrosis (HP:0005576) | 2.54167431 |
52 | Abnormality of nucleobase metabolism (HP:0010932) | 2.51688442 |
53 | Abnormal urine output (HP:0012590) | 2.51146983 |
54 | Cerebral inclusion bodies (HP:0100314) | 2.40041128 |
55 | Focal segmental glomerulosclerosis (HP:0000097) | 2.39787732 |
56 | Aplasia of the phalanges of the hand (HP:0009802) | 2.38168023 |
57 | Aplasia involving bones of the extremities (HP:0009825) | 2.38168023 |
58 | Aplasia involving bones of the upper limbs (HP:0009823) | 2.38168023 |
59 | Cardiovascular calcification (HP:0011915) | 2.37690306 |
60 | Flat acetabular roof (HP:0003180) | 2.37422438 |
61 | Hypoalphalipoproteinemia (HP:0003233) | 2.36554906 |
62 | Back pain (HP:0003418) | 2.36163195 |
63 | Prolonged partial thromboplastin time (HP:0003645) | 2.35582457 |
64 | Bronchomalacia (HP:0002780) | 2.35291289 |
65 | Hepatocellular carcinoma (HP:0001402) | 2.33812768 |
66 | Abnormality of the distal phalanges of the toes (HP:0010182) | 2.33463773 |
67 | Abnormality of renin-angiotensin system (HP:0000847) | 2.31804188 |
68 | Neonatal onset (HP:0003623) | 2.31715957 |
69 | Abnormality of the distal phalanx of the thumb (HP:0009617) | 2.29132907 |
70 | Ulnar bowing (HP:0003031) | 2.26080097 |
71 | Abnormality of the dental pulp (HP:0006479) | 2.25754810 |
72 | Abnormality of molar morphology (HP:0011070) | 2.25029177 |
73 | Abnormality of molar (HP:0011077) | 2.25029177 |
74 | Sensorimotor neuropathy (HP:0007141) | 2.23045768 |
75 | Polyuria (HP:0000103) | 2.20616003 |
76 | Abnormality of the nasal septum (HP:0000419) | 2.19037443 |
77 | Abnormality of the common coagulation pathway (HP:0010990) | 2.19034133 |
78 | Hypoplasia of dental enamel (HP:0006297) | 2.18549719 |
79 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 2.16789417 |
80 | Septate vagina (HP:0001153) | 2.16164784 |
81 | Lip pit (HP:0100267) | 2.15575990 |
82 | Right ventricular cardiomyopathy (HP:0011663) | 2.15168136 |
83 | Hydroxyprolinuria (HP:0003080) | 2.14710457 |
84 | Abnormality of proline metabolism (HP:0010907) | 2.14710457 |
85 | Missing ribs (HP:0000921) | 2.13511583 |
86 | Abnormality of the lower motor neuron (HP:0002366) | 2.12778760 |
87 | Neurofibrillary tangles (HP:0002185) | 2.09086004 |
88 | Advanced eruption of teeth (HP:0006288) | 2.06613712 |
89 | Nephrolithiasis (HP:0000787) | 2.05332928 |
90 | Pterygium (HP:0001059) | 2.03309881 |
91 | Bifid scrotum (HP:0000048) | 2.02748785 |
92 | Amelogenesis imperfecta (HP:0000705) | 2.02625799 |
93 | Interstitial pulmonary disease (HP:0006530) | 2.00285550 |
94 | Hypomagnesemia (HP:0002917) | 2.00101746 |
95 | Rickets (HP:0002748) | 1.99133460 |
96 | Lymphangioma (HP:0100764) | 1.98390889 |
97 | Milia (HP:0001056) | 1.95535945 |
98 | Hepatoblastoma (HP:0002884) | 1.94307036 |
99 | Concave nail (HP:0001598) | 1.93547716 |
100 | Hypotrichosis (HP:0001006) | 1.93016448 |
101 | Unilateral renal agenesis (HP:0000122) | 1.92672462 |
102 | Abnormality of the gastric mucosa (HP:0004295) | 1.92338437 |
103 | Status epilepticus (HP:0002133) | 1.92168321 |
104 | Dysmetric saccades (HP:0000641) | 1.90543689 |
105 | Abnormality of the Achilles tendon (HP:0005109) | 1.89846998 |
106 | Abnormality of complement system (HP:0005339) | 1.89589952 |
107 | Enlarged kidneys (HP:0000105) | 1.89557876 |
108 | Steatorrhea (HP:0002570) | 1.87890226 |
109 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 1.87610848 |
110 | Hypercholesterolemia (HP:0003124) | 1.87436778 |
111 | Megalencephaly (HP:0001355) | 1.86542825 |
112 | Dehydration (HP:0001944) | 1.85107904 |
113 | Conjugated hyperbilirubinemia (HP:0002908) | 1.85011069 |
114 | Tachypnea (HP:0002789) | 1.83049010 |
115 | Late onset (HP:0003584) | 1.82707031 |
116 | Tibial bowing (HP:0002982) | 1.82642543 |
117 | Hypoglycemic coma (HP:0001325) | 1.82495404 |
118 | Myokymia (HP:0002411) | 1.82050836 |
119 | Abnormality of fatty-acid metabolism (HP:0004359) | 1.81909590 |
120 | Bicornuate uterus (HP:0000813) | 1.80731649 |
121 | Metabolic acidosis (HP:0001942) | 1.79554151 |
122 | Spinal cord compression (HP:0002176) | 1.79553933 |
123 | Vertebral hypoplasia (HP:0008417) | 1.78848740 |
124 | Aplasia/Hypoplasia of the vertebrae (HP:0008515) | 1.78848740 |
125 | Progressive sensorineural hearing impairment (HP:0000408) | 1.77615396 |
126 | Urethral obstruction (HP:0000796) | 1.77370573 |
127 | Irritability (HP:0000737) | 1.75651333 |
128 | Confusion (HP:0001289) | 1.75321228 |
129 | Onycholysis (HP:0001806) | 1.74401241 |
130 | Selective tooth agenesis (HP:0001592) | 1.74347831 |
131 | Visceral angiomatosis (HP:0100761) | 1.73608181 |
132 | Abnormality of the lacrimal duct (HP:0011481) | 1.72710083 |
133 | Abnormality of the intrinsic pathway (HP:0010989) | 1.72613940 |
134 | Proximal tubulopathy (HP:0000114) | 1.72412245 |
135 | Hypotension (HP:0002615) | 1.72245301 |
136 | Partial duplication of thumb phalanx (HP:0009944) | 1.71573405 |
137 | Vertebral arch anomaly (HP:0008438) | 1.71472319 |
138 | Abnormal hair laboratory examination (HP:0003328) | 1.71203360 |
139 | Abnormality of the salivary glands (HP:0010286) | 1.69627067 |
140 | Nasolacrimal duct obstruction (HP:0000579) | 1.68506404 |
141 | Abnormality of magnesium homeostasis (HP:0004921) | 1.67952560 |
142 | Joint hemorrhage (HP:0005261) | 1.67893102 |
143 | Bowing of the arm (HP:0006488) | 1.67359576 |
144 | Bowed forearm bones (HP:0003956) | 1.67359576 |
145 | Curly hair (HP:0002212) | 1.66680834 |
146 | Hypercalciuria (HP:0002150) | 1.65719840 |
147 | Pseudobulbar signs (HP:0002200) | 1.65548413 |
148 | Mitral stenosis (HP:0001718) | 1.64709413 |
149 | Coronal craniosynostosis (HP:0004440) | 1.64403874 |
150 | Shallow orbits (HP:0000586) | 1.63556837 |
151 | Renal tubular acidosis (HP:0001947) | 1.62596459 |
152 | Overriding aorta (HP:0002623) | 1.62520771 |
153 | Chronic bronchitis (HP:0004469) | 1.62189903 |
154 | Hyperparathyroidism (HP:0000843) | 1.62108326 |
155 | Sparse lateral eyebrow (HP:0005338) | 1.61713961 |
156 | Testicular atrophy (HP:0000029) | 1.60257148 |
157 | Facial cleft (HP:0002006) | 1.59579047 |
158 | Esophageal atresia (HP:0002032) | 1.59056484 |
159 | Germ cell neoplasia (HP:0100728) | 1.58670199 |
160 | Fibular aplasia (HP:0002990) | 1.58622670 |
161 | Elfin facies (HP:0004428) | 1.58572357 |
162 | Oligodontia (HP:0000677) | 1.57661987 |
163 | Sparse eyelashes (HP:0000653) | 1.57366379 |
164 | Hypoplastic labia majora (HP:0000059) | 1.56748870 |
165 | Abdominal distention (HP:0003270) | 1.54232663 |
166 | Fragile nails (HP:0001808) | 1.53952560 |
167 | 11 pairs of ribs (HP:0000878) | 1.53485604 |
168 | Alopecia of scalp (HP:0002293) | 1.51822478 |
169 | Macroorchidism (HP:0000053) | 1.51179604 |
170 | Vertebral clefting (HP:0008428) | 1.49927702 |
171 | Tubular atrophy (HP:0000092) | 1.49869580 |
172 | Abnormality of nail color (HP:0100643) | 1.49664038 |
173 | Progressive hearing impairment (HP:0001730) | 1.48352105 |
174 | Absent eyebrow (HP:0002223) | 1.47408471 |
175 | Microretrognathia (HP:0000308) | 1.47201975 |
176 | Asymmetry of the thorax (HP:0001555) | 1.46945045 |
177 | Deviation of the thumb (HP:0009603) | 1.46326359 |
178 | Micronodular cirrhosis (HP:0001413) | 1.45811951 |
179 | Congenital glaucoma (HP:0001087) | 1.44521178 |
180 | Broad nasal tip (HP:0000455) | 1.43970538 |
181 | Obstructive sleep apnea (HP:0002870) | 1.43968294 |
Rank | Gene Set | Z-score |
---|---|---|
1 | EPHA2 | 2.62456206 |
2 | MAP3K9 | 2.60199117 |
3 | TRIB3 | 2.48968311 |
4 | DAPK2 | 2.46627446 |
5 | EPHA4 | 2.44912011 |
6 | SIK1 | 2.31824957 |
7 | WNK3 | 2.29657351 |
8 | LATS1 | 2.23293782 |
9 | WNK4 | 2.16412238 |
10 | CDK12 | 2.14540900 |
11 | RIPK1 | 2.09102699 |
12 | LMTK2 | 2.07402665 |
13 | TSSK6 | 1.98095706 |
14 | OXSR1 | 1.87218244 |
15 | CAMK1D | 1.87174358 |
16 | IRAK3 | 1.85929574 |
17 | MAP3K2 | 1.83093790 |
18 | SMG1 | 1.79509218 |
19 | FER | 1.78664574 |
20 | BCKDK | 1.77375187 |
21 | KSR2 | 1.76755682 |
22 | LATS2 | 1.75299681 |
23 | MARK1 | 1.67305496 |
24 | DDR2 | 1.65338761 |
25 | ERN1 | 1.64709947 |
26 | FGFR4 | 1.62156199 |
27 | PKN2 | 1.60582390 |
28 | NTRK1 | 1.60062637 |
29 | PTK2 | 1.54678268 |
30 | FGFR2 | 1.53000107 |
31 | PTK6 | 1.52854420 |
32 | TYRO3 | 1.51846119 |
33 | MST1R | 1.47213767 |
34 | STK38 | 1.38103648 |
35 | RPS6KB2 | 1.37594251 |
36 | PAK6 | 1.37382518 |
37 | PRKD3 | 1.35541044 |
38 | MAP3K12 | 1.35112218 |
39 | EPHB2 | 1.31292768 |
40 | PDGFRA | 1.30421623 |
41 | ERBB4 | 1.29970629 |
42 | MAP2K4 | 1.27874985 |
43 | MST4 | 1.27547648 |
44 | FRK | 1.26508825 |
45 | MAPK15 | 1.25434125 |
46 | PAK3 | 1.18979013 |
47 | STK38L | 1.17729555 |
48 | MINK1 | 1.17608423 |
49 | CAMKK1 | 1.17603476 |
50 | NTRK3 | 1.14426007 |
51 | ERBB2 | 1.13173700 |
52 | BMX | 1.10591530 |
53 | KSR1 | 1.07571212 |
54 | TAOK1 | 1.03165573 |
55 | NEK1 | 1.02572048 |
56 | NEK6 | 1.01229579 |
57 | MAP3K7 | 0.99900484 |
58 | NTRK2 | 0.98919557 |
59 | SGK3 | 0.98445523 |
60 | LRRK2 | 0.98218092 |
61 | ICK | 0.96937858 |
62 | CASK | 0.96596700 |
63 | NME1 | 0.94221116 |
64 | MAP3K4 | 0.93990624 |
65 | PAK4 | 0.93843691 |
66 | PIM2 | 0.93428397 |
67 | RET | 0.92191367 |
68 | MET | 0.90933488 |
69 | MAPKAPK3 | 0.89687950 |
70 | MAP2K1 | 0.88840858 |
71 | ARAF | 0.88370609 |
72 | TESK1 | 0.87477440 |
73 | SGK494 | 0.87349143 |
74 | SGK223 | 0.87349143 |
75 | DAPK1 | 0.86899819 |
76 | STK39 | 0.86644570 |
77 | CAMK2B | 0.82573000 |
78 | EIF2AK1 | 0.79577556 |
79 | MAP2K2 | 0.76647440 |
80 | PBK | 0.76494965 |
81 | DYRK1B | 0.75192472 |
82 | FGFR1 | 0.74559218 |
83 | PRKCI | 0.73698144 |
84 | GSK3A | 0.72205984 |
85 | WEE1 | 0.69100296 |
86 | EPHB1 | 0.68204812 |
87 | SGK2 | 0.66650180 |
88 | MAP3K3 | 0.66342996 |
89 | DMPK | 0.65769522 |
90 | CDK5 | 0.65139346 |
91 | NME2 | 0.64516009 |
92 | CDK8 | 0.64385691 |
93 | ILK | 0.63759095 |
94 | CAMK2D | 0.59682595 |
95 | TTK | 0.59300355 |
96 | MTOR | 0.58837704 |
97 | IRAK2 | 0.58103990 |
98 | BRSK1 | 0.57933325 |
99 | CDK6 | 0.57013222 |
100 | * PRKCZ | 0.54107299 |
101 | GRK6 | 0.54097275 |
102 | PDGFRB | 0.53745111 |
103 | AKT3 | 0.51847434 |
104 | CAMK1G | 0.51612870 |
105 | PDPK1 | 0.51500486 |
106 | PAK2 | 0.50456044 |
107 | ALK | 0.50419866 |
108 | STK11 | 0.50286408 |
109 | PHKG1 | 0.49025197 |
110 | PHKG2 | 0.49025197 |
111 | CSNK1G2 | 0.48889160 |
112 | ROCK1 | 0.48834035 |
113 | MARK2 | 0.48750370 |
114 | PRKD2 | 0.47690602 |
115 | AKT2 | 0.47579093 |
116 | PRKCG | 0.46094853 |
117 | MATK | 0.45976210 |
118 | IRAK1 | 0.45532052 |
119 | CDK7 | 0.43408925 |
120 | SGK1 | 0.43248801 |
121 | MAP3K1 | 0.39689736 |
122 | RPS6KA2 | 0.39200410 |
123 | MAP3K10 | 0.38485926 |
124 | PRKG2 | 0.38288930 |
125 | CSNK1E | 0.37657458 |
126 | PNCK | 0.36583612 |
127 | EEF2K | 0.36540658 |
128 | EGFR | 0.36300260 |
129 | SCYL2 | 0.36233112 |
130 | STK3 | 0.35290901 |
131 | PRKCH | 0.34359483 |
132 | PRKAA1 | 0.34001058 |
133 | CAMK2G | 0.33652613 |
134 | FGFR3 | 0.33529244 |
135 | MELK | 0.33297362 |
136 | EPHA3 | 0.32995497 |
137 | MUSK | 0.32570793 |
138 | PIK3CA | 0.31257352 |
139 | * AURKB | 0.29614284 |
140 | BRAF | 0.28812640 |
141 | BCR | 0.28239741 |
142 | TAF1 | 0.27900580 |
143 | BRSK2 | 0.27813652 |
144 | CDK9 | 0.23328888 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Nitrogen metabolism_Homo sapiens_hsa00910 | 4.19113732 |
2 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 3.07184746 |
3 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 2.87876003 |
4 | Arginine biosynthesis_Homo sapiens_hsa00220 | 2.65318322 |
5 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 2.65124440 |
6 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 2.35481800 |
7 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 2.34575563 |
8 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.24111354 |
9 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.19524960 |
10 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.18143471 |
11 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 2.14439053 |
12 | Bile secretion_Homo sapiens_hsa04976 | 2.14191416 |
13 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.11571612 |
14 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.97621250 |
15 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.79678180 |
16 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.79360734 |
17 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.76083648 |
18 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.69443349 |
19 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.67259232 |
20 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.65206521 |
21 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.59483176 |
22 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.58872066 |
23 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.53134247 |
24 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 1.49391861 |
25 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.44366357 |
26 | Histidine metabolism_Homo sapiens_hsa00340 | 1.44172381 |
27 | Peroxisome_Homo sapiens_hsa04146 | 1.43748166 |
28 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.41579049 |
29 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.41277420 |
30 | Thyroid cancer_Homo sapiens_hsa05216 | 1.39776259 |
31 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.36251844 |
32 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.25969319 |
33 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.21034932 |
34 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.17940548 |
35 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.13623263 |
36 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.10173280 |
37 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.08944018 |
38 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.07384249 |
39 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.05005510 |
40 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.04303438 |
41 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.01802731 |
42 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.01768226 |
43 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 1.00042576 |
44 | Retinol metabolism_Homo sapiens_hsa00830 | 0.99844077 |
45 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.99822963 |
46 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.99089325 |
47 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.99087067 |
48 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.98983599 |
49 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.98813730 |
50 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.94179371 |
51 | Carbon metabolism_Homo sapiens_hsa01200 | 0.92512834 |
52 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.88919530 |
53 | Mineral absorption_Homo sapiens_hsa04978 | 0.88295650 |
54 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.87331564 |
55 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.86605560 |
56 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.85446547 |
57 | Lysine degradation_Homo sapiens_hsa00310 | 0.85230324 |
58 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.84060904 |
59 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.83689544 |
60 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.83041941 |
61 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.82492591 |
62 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.79081724 |
63 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.77956109 |
64 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.76807380 |
65 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.74770437 |
66 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.74020394 |
67 | Galactose metabolism_Homo sapiens_hsa00052 | 0.72364028 |
68 | ABC transporters_Homo sapiens_hsa02010 | 0.72088357 |
69 | Bladder cancer_Homo sapiens_hsa05219 | 0.68552361 |
70 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.68157635 |
71 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.67632755 |
72 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.66248373 |
73 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.65392566 |
74 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.64641069 |
75 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.64412465 |
76 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.64196509 |
77 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.64167408 |
78 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.64156733 |
79 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.63314679 |
80 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.62288544 |
81 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.60762393 |
82 | Focal adhesion_Homo sapiens_hsa04510 | 0.60413896 |
83 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.59427199 |
84 | Circadian rhythm_Homo sapiens_hsa04710 | 0.58829867 |
85 | Prostate cancer_Homo sapiens_hsa05215 | 0.57636652 |
86 | Salivary secretion_Homo sapiens_hsa04970 | 0.57367234 |
87 | Tight junction_Homo sapiens_hsa04530 | 0.57228111 |
88 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.57049939 |
89 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.55084248 |
90 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.54407818 |
91 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.53023540 |
92 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.52154223 |
93 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.51885568 |
94 | Cocaine addiction_Homo sapiens_hsa05030 | 0.51161380 |
95 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.50301337 |
96 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.50299096 |
97 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.48172063 |
98 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.47060739 |
99 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.46480885 |
100 | GABAergic synapse_Homo sapiens_hsa04727 | 0.46279703 |
101 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.45087048 |
102 | Adherens junction_Homo sapiens_hsa04520 | 0.44904824 |
103 | Nicotine addiction_Homo sapiens_hsa05033 | 0.44427710 |
104 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.43670351 |
105 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.43615936 |
106 | * Hippo signaling pathway_Homo sapiens_hsa04390 | 0.42356592 |
107 | Endometrial cancer_Homo sapiens_hsa05213 | 0.42032365 |
108 | Prion diseases_Homo sapiens_hsa05020 | 0.40413285 |
109 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.38538177 |
110 | Insulin resistance_Homo sapiens_hsa04931 | 0.35668869 |
111 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.34732746 |
112 | Glioma_Homo sapiens_hsa05214 | 0.33998400 |
113 | Insulin secretion_Homo sapiens_hsa04911 | 0.33864521 |
114 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.31928970 |
115 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.31274337 |
116 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.29593318 |
117 | Melanogenesis_Homo sapiens_hsa04916 | 0.28797878 |
118 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.28793830 |
119 | Axon guidance_Homo sapiens_hsa04360 | 0.28646812 |
120 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.28414731 |
121 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.28272795 |
122 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.28072318 |
123 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.27672689 |
124 | Long-term potentiation_Homo sapiens_hsa04720 | 0.27592811 |
125 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.27544382 |
126 | Gap junction_Homo sapiens_hsa04540 | 0.25488911 |
127 | Sulfur relay system_Homo sapiens_hsa04122 | 0.25180279 |
128 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.24941927 |
129 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.24915940 |
130 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.24265547 |
131 | Olfactory transduction_Homo sapiens_hsa04740 | 0.23448722 |
132 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.23126520 |
133 | Renin secretion_Homo sapiens_hsa04924 | 0.22519652 |