WWC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WW-and-C2-domain-containing family of proteins. Members of this family have two N-terminal WW domains that mediate binding to target proteins harboring L/PPxY motifs, an internal C2 domain for membrane association, and C-terminal alpha protein kinase C binding sites and class III PDZ domain-interaction motifs. Proteins of this family are able to form homo- and heterodimers and to modulate hippo pathway signaling. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)5.18179216
2notochord development (GO:0030903)4.06086786
3hippo signaling (GO:0035329)3.85717902
4regulation of cardioblast differentiation (GO:0051890)3.60807488
5* regulation of hippo signaling (GO:0035330)3.56193632
6regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.45978704
7nuclear pore complex assembly (GO:0051292)3.36824461
8protein complex localization (GO:0031503)3.34695771
9regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.30029612
10polarized epithelial cell differentiation (GO:0030859)3.29947179
11endothelial cell morphogenesis (GO:0001886)3.27320478
12cellular protein complex localization (GO:0034629)3.23610096
13mitotic chromosome condensation (GO:0007076)3.17570488
14regulation of mitotic spindle organization (GO:0060236)3.17228184
15regulation of spindle organization (GO:0090224)3.16118740
16establishment of integrated proviral latency (GO:0075713)3.15885536
17plasma membrane repair (GO:0001778)3.15086619
18chondrocyte proliferation (GO:0035988)3.14952314
19epithelial cell-cell adhesion (GO:0090136)3.14313576
20regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.12833496
21pre-miRNA processing (GO:0031054)3.12664050
22planar cell polarity pathway involved in neural tube closure (GO:0090179)3.12582046
23heterochromatin organization (GO:0070828)3.08105012
24gap junction assembly (GO:0016264)3.06317412
25endocardial cushion development (GO:0003197)3.03897572
26histone H2A monoubiquitination (GO:0035518)3.02954609
27regulation of cell fate specification (GO:0042659)3.02805218
28glomerular visceral epithelial cell development (GO:0072015)2.98301214
29positive regulation of SMAD protein import into nucleus (GO:0060391)2.98074073
30positive regulation of catenin import into nucleus (GO:0035413)2.97855868
31nuclear pore organization (GO:0006999)2.97010821
32establishment of apical/basal cell polarity (GO:0035089)2.96703668
33regulation of SMAD protein import into nucleus (GO:0060390)2.96323509
34mitotic metaphase plate congression (GO:0007080)2.96263144
35monoubiquitinated protein deubiquitination (GO:0035520)2.95977007
36G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.95334182
37regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.93187502
38stress fiber assembly (GO:0043149)2.92850190
39regulation of gene silencing by RNA (GO:0060966)2.90519587
40regulation of posttranscriptional gene silencing (GO:0060147)2.90519587
41regulation of gene silencing by miRNA (GO:0060964)2.90519587
42adherens junction assembly (GO:0034333)2.86088143
43piRNA metabolic process (GO:0034587)2.86046744
44cell adhesion mediated by integrin (GO:0033627)2.85542922
45cardiac myofibril assembly (GO:0055003)2.84204232
46synaptonemal complex assembly (GO:0007130)2.82690040
47convergent extension (GO:0060026)2.80312822
48negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.79442048
49regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.79341480
50basement membrane organization (GO:0071711)2.77923840
51retina vasculature morphogenesis in camera-type eye (GO:0061299)2.75510205
52ventricular cardiac muscle cell development (GO:0055015)2.74606034
53regulation of tight junction assembly (GO:2000810)2.74166055
54collagen fibril organization (GO:0030199)2.73661944
55negative regulation of chondrocyte differentiation (GO:0032331)2.73490956
56negative regulation of DNA repair (GO:0045738)2.70320996
57protein heterotrimerization (GO:0070208)2.68104075
58protein localization to endosome (GO:0036010)2.67831526
59mitotic cytokinesis (GO:0000281)2.67270420
60wound healing, spreading of cells (GO:0044319)2.65620000
61regulation of RNA export from nucleus (GO:0046831)2.65326606
62DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.64484274
63endodermal cell differentiation (GO:0035987)2.64442857
64regulation of integrin-mediated signaling pathway (GO:2001044)2.64159455
65regulation of sister chromatid cohesion (GO:0007063)2.63986801
66mitotic sister chromatid cohesion (GO:0007064)2.62608467
67DNA unwinding involved in DNA replication (GO:0006268)2.62151571
68cytoplasmic mRNA processing body assembly (GO:0033962)2.62013975
69anterior/posterior axis specification, embryo (GO:0008595)2.61517716
70regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.61329148
71regulation of transforming growth factor beta2 production (GO:0032909)2.60516868
72mitotic sister chromatid segregation (GO:0000070)2.60304924
73DNA damage response, signal transduction resulting in transcription (GO:0042772)2.58680743
74glomerular basement membrane development (GO:0032836)2.56374842
75negative regulation of focal adhesion assembly (GO:0051895)2.55852483
76negative regulation of cell junction assembly (GO:1901889)2.55852483
77negative regulation of adherens junction organization (GO:1903392)2.55852483
78embryonic foregut morphogenesis (GO:0048617)2.55733773
79cell migration involved in sprouting angiogenesis (GO:0002042)2.55619218
80substrate adhesion-dependent cell spreading (GO:0034446)2.55351184
81cell-substrate junction assembly (GO:0007044)2.55008041
82protein localization to kinetochore (GO:0034501)2.54950444
83synaptonemal complex organization (GO:0070193)2.53639899
84L-serine metabolic process (GO:0006563)2.53036630
85wound healing, spreading of epidermal cells (GO:0035313)2.52519882
86glomerular epithelial cell development (GO:0072310)2.51217993
87vascular endothelial growth factor signaling pathway (GO:0038084)2.50755203
88negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.49868783
89cell-substrate adherens junction assembly (GO:0007045)2.47553108
90focal adhesion assembly (GO:0048041)2.47553108
91regulation of meiosis I (GO:0060631)2.46781497
92mesenchyme development (GO:0060485)2.46546353
93lung-associated mesenchyme development (GO:0060484)2.45657261
94protein localization to chromosome, centromeric region (GO:0071459)2.45599097
95bundle of His cell to Purkinje myocyte communication (GO:0086069)2.45315275
96cardiac muscle cell development (GO:0055013)2.44072919
97lymphangiogenesis (GO:0001946)2.42789492
98mitotic nuclear envelope disassembly (GO:0007077)2.41111419
99negative regulation of cardiac muscle tissue development (GO:0055026)2.41044761
100sister chromatid segregation (GO:0000819)2.40735461
101regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.40068530
102positive regulation of endothelial cell apoptotic process (GO:2000353)2.39907594
103dorsal/ventral axis specification (GO:0009950)2.38950321
104NLS-bearing protein import into nucleus (GO:0006607)2.38747803
105regulation of clathrin-mediated endocytosis (GO:2000369)2.37518053
106fibroblast migration (GO:0010761)2.36871473
107ribosome assembly (GO:0042255)2.35604476
108branching involved in salivary gland morphogenesis (GO:0060445)2.35544603
109positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.34496660
110regulation of catenin import into nucleus (GO:0035412)2.34397792
111negative regulation of cell fate specification (GO:0009996)2.34295165
112mesodermal cell differentiation (GO:0048333)2.34232245
113regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.33407850
114metaphase plate congression (GO:0051310)2.32975028
115regulation of integrin activation (GO:0033623)2.32954891
116pore complex assembly (GO:0046931)2.32633933
117membrane disassembly (GO:0030397)2.32005333
118nuclear envelope disassembly (GO:0051081)2.32005333
119positive regulation of epithelial to mesenchymal transition (GO:0010718)2.31979681
120cardiac cell development (GO:0055006)2.31785255
121establishment of monopolar cell polarity (GO:0061162)2.31562916
122establishment or maintenance of monopolar cell polarity (GO:0061339)2.31562916
123cell fate commitment involved in formation of primary germ layer (GO:0060795)2.31446316
124positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.31142611
125Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.31049928
126spindle assembly involved in mitosis (GO:0090307)2.30142598
127negative regulation of hormone metabolic process (GO:0032351)2.29486421
128negative regulation of hormone biosynthetic process (GO:0032353)2.29486421
129gene silencing by RNA (GO:0031047)2.28927381
130sarcomere organization (GO:0045214)2.28741105
131tight junction assembly (GO:0070830)2.28652106
132regulation of non-canonical Wnt signaling pathway (GO:2000050)2.28626085
133skin morphogenesis (GO:0043589)2.28547741
134nodal signaling pathway (GO:0038092)2.26991337
135negative regulation of smooth muscle cell differentiation (GO:0051151)2.26497575
136regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.25160309
137bone trabecula formation (GO:0060346)2.24859865
138nucleotide-sugar biosynthetic process (GO:0009226)2.24589599
139positive regulation of osteoblast proliferation (GO:0033690)2.23743051
140regulation of translational fidelity (GO:0006450)2.23483045
141regulation of establishment of planar polarity (GO:0090175)2.22789428
142positive regulation of cardiac muscle cell proliferation (GO:0060045)2.22578250
143regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.21580638
144regulation of apoptotic cell clearance (GO:2000425)2.21077250
145regulation of stem cell maintenance (GO:2000036)2.21028113
146negative regulation of keratinocyte proliferation (GO:0010839)2.20451242
147morphogenesis of an epithelial sheet (GO:0002011)2.20302468
148midgut development (GO:0007494)2.18575090
149cell migration involved in gastrulation (GO:0042074)2.17851130
150apoptotic cell clearance (GO:0043277)2.17443940
151chemical homeostasis within a tissue (GO:0048875)2.17311263

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human3.77832137
2NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.59693763
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.77896419
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.68731736
5AR_21909140_ChIP-Seq_LNCAP_Human2.64721691
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.56400432
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.50486653
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.44809833
9* SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.44235570
10WT1_19549856_ChIP-ChIP_CCG9911_Human2.43419107
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.43350986
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.37721931
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.33151764
14SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.19980965
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.17683145
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.16027387
17EP300_21415370_ChIP-Seq_HL-1_Mouse2.10489681
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.08094793
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.08094793
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.08094793
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.07616013
22POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.06241555
23* TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.03023410
24STAT6_21828071_ChIP-Seq_BEAS2B_Human2.00176849
25TCF3_18692474_ChIP-Seq_MEFs_Mouse1.94266849
26ZNF263_19887448_ChIP-Seq_K562_Human1.90911479
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.90100584
28ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.84710055
29HIF1A_21447827_ChIP-Seq_MCF-7_Human1.84435559
30RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.82955833
31ATF3_27146783_Chip-Seq_COLON_Human1.81736558
32FOXO3_23340844_ChIP-Seq_DLD1_Human1.77614287
33* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.77501089
34PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.77106168
35HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.76730523
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.75882282
37NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.73843987
38PPAR_26484153_Chip-Seq_NCI-H1993_Human1.72078726
39TCF3_18692474_ChIP-Seq_MESCs_Mouse1.71739720
40* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.70127662
41CLOCK_20551151_ChIP-Seq_293T_Human1.69462498
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.67537313
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.67229017
44P300_27058665_Chip-Seq_ZR-75-30cells_Human1.65593740
45* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.60434992
46E2F7_22180533_ChIP-Seq_HELA_Human1.60406852
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56409642
48NANOG_16153702_ChIP-ChIP_HESCs_Human1.56345638
49* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.56148315
50CJUN_26792858_Chip-Seq_BT549_Human1.54438985
51ESR1_20079471_ChIP-ChIP_T-47D_Human1.53355393
52BRD4_25478319_ChIP-Seq_HGPS_Human1.52634840
53ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.52404798
54SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.49588368
55TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47271142
56* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.47041783
57UBF1/2_26484160_Chip-Seq_HMECs_Human1.46572910
58* SOX17_20123909_ChIP-Seq_XEN_Mouse1.44631053
59* ISL1_27105846_Chip-Seq_CPCs_Mouse1.44626314
60MYC_19030024_ChIP-ChIP_MESCs_Mouse1.43813932
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.40804238
62SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.40743518
63ESR1_21235772_ChIP-Seq_MCF-7_Human1.40131962
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38579927
65CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.38475381
66SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.36475470
67TP53_16413492_ChIP-PET_HCT116_Human1.36416810
68TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.36074378
69* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.34865152
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34864519
71TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33682509
72FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.32843165
73POU5F1_16518401_ChIP-PET_MESCs_Mouse1.32232990
74TP53_22127205_ChIP-Seq_IMR90_Human1.31937275
75ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31731033
76PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31564447
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31552658
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.30363965
79MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.29688743
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29446440
81* NANOG_21062744_ChIP-ChIP_HESCs_Human1.29166703
82NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.29096712
83* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.28544688
84TBX3_20139965_ChIP-Seq_ESCs_Mouse1.28021342
85TBX3_20139965_ChIP-Seq_MESCs_Mouse1.26895800
86EGR1_19374776_ChIP-ChIP_THP-1_Human1.26118953
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25859492
88KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24634251
89KDM2B_26808549_Chip-Seq_K562_Human1.24551646
90* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23727911
91* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.23034368
92RUNX1_27514584_Chip-Seq_MCF-7_Human1.19671735
93* TBX20_22328084_ChIP-Seq_HEART_Mouse1.18807706
94* TBX20_22080862_ChIP-Seq_HEART_Mouse1.18807706
95* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17635787
96SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16684948
97SOX9_24532713_ChIP-Seq_HFSC_Mouse1.16405878
98* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16119383
99NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.16052322
100POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15486942
101TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15228527
102ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15101975
103CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.13740233
104SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.13684449
105RACK7_27058665_Chip-Seq_MCF-7_Human1.13478553
106SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11863977
107SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11863977
108EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.11495400
109NANOG_18692474_ChIP-Seq_MESCs_Mouse1.11031901
110SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10381854
111ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09761800
112SMAD_19615063_ChIP-ChIP_OVARY_Human1.09249873
113TP63_19390658_ChIP-ChIP_HaCaT_Human1.08828473
114STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08558566
115KDM2B_26808549_Chip-Seq_DND41_Human1.05733769
116TP53_23651856_ChIP-Seq_MEFs_Mouse1.05657452
117CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05636049
118NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03788900
119MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03785970
120DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02799703
121KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02767149
122KDM2B_26808549_Chip-Seq_JURKAT_Human1.01253870
123ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00668180
124SOX2_16153702_ChIP-ChIP_HESCs_Human1.00460490
125E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00391352
126NANOG_18692474_ChIP-Seq_MEFs_Mouse0.99674109
127ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98219802
128JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98203933
129KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97852218
130CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95352939
131POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94859842
132POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.93807725
133EOMES_21245162_ChIP-Seq_HESCs_Human0.92951940
134YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92581521
135* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91954986
136* FOXA2_19822575_ChIP-Seq_HepG2_Human0.91861819
137FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91065593
138TCF4_18268006_ChIP-ChIP_LS174T_Human0.90754764

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.59451998
2MP0005623_abnormal_meninges_morphology3.35032842
3MP0003705_abnormal_hypodermis_morpholog3.22413791
4MP0004272_abnormal_basement_membrane2.82346160
5MP0005275_abnormal_skin_tensile2.20173404
6MP0004185_abnormal_adipocyte_glucose2.12268461
7MP0003566_abnormal_cell_adhesion2.10758511
8MP0002254_reproductive_system_inflammat2.08906358
9MP0003890_abnormal_embryonic-extraembry2.05386942
10MP0002653_abnormal_ependyma_morphology2.05218593
11MP0004084_abnormal_cardiac_muscle1.99924000
12MP0010352_gastrointestinal_tract_polyps1.87547153
13MP0001958_emphysema1.83785528
14MP0003279_aneurysm1.82954515
15MP0003937_abnormal_limbs/digits/tail_de1.79141693
16MP0010030_abnormal_orbit_morphology1.78487925
17MP0010368_abnormal_lymphatic_system1.77141446
18MP0000733_abnormal_muscle_development1.67785178
19MP0003385_abnormal_body_wall1.65866114
20MP0006138_congestive_heart_failure1.64383026
21MP0003950_abnormal_plasma_membrane1.64012610
22MP0003091_abnormal_cell_migration1.60850618
23MP0005451_abnormal_body_composition1.59307971
24MP0002084_abnormal_developmental_patter1.57067474
25MP0005503_abnormal_tendon_morphology1.52825957
26MP0009384_cardiac_valve_regurgitation1.51008648
27MP0009053_abnormal_anal_canal1.50101174
28MP0001730_embryonic_growth_arrest1.49355191
29MP0003941_abnormal_skin_development1.49220663
30MP0001293_anophthalmia1.48223185
31MP0000537_abnormal_urethra_morphology1.47728770
32MP0001661_extended_life_span1.47030629
33MP0005380_embryogenesis_phenotype1.46682315
34MP0001672_abnormal_embryogenesis/_devel1.46682315
35MP0002085_abnormal_embryonic_tissue1.46163493
36MP0009672_abnormal_birth_weight1.46030800
37MP0005257_abnormal_intraocular_pressure1.44461887
38MP0003984_embryonic_growth_retardation1.40779921
39MP0006054_spinal_hemorrhage1.40769857
40MP0003693_abnormal_embryo_hatching1.39269938
41MP0003646_muscle_fatigue1.37891605
42MP0002088_abnormal_embryonic_growth/wei1.36975971
43MP0009250_abnormal_appendicular_skeleto1.35661191
44MP0004233_abnormal_muscle_weight1.33165762
45MP0003123_paternal_imprinting1.32933319
46MP0002877_abnormal_melanocyte_morpholog1.32855365
47MP0005666_abnormal_adipose_tissue1.30003474
48MP0005076_abnormal_cell_differentiation1.29531757
49MP0000750_abnormal_muscle_regeneration1.28966203
50MP0003755_abnormal_palate_morphology1.28913935
51MP0001697_abnormal_embryo_size1.27716577
52MP0003111_abnormal_nucleus_morphology1.26669124
53MP0005508_abnormal_skeleton_morphology1.26011770
54MP0005023_abnormal_wound_healing1.25148913
55MP0010630_abnormal_cardiac_muscle1.24922170
56MP0002086_abnormal_extraembryonic_tissu1.24837637
57MP0001849_ear_inflammation1.24496527
58MP0001915_intracranial_hemorrhage1.23654965
59MP0003077_abnormal_cell_cycle1.23299937
60MP0003935_abnormal_craniofacial_develop1.22839771
61MP0003115_abnormal_respiratory_system1.22690520
62MP0010094_abnormal_chromosome_stability1.22508980
63MP0000767_abnormal_smooth_muscle1.22076031
64MP0004087_abnormal_muscle_fiber1.21824565
65MP0004957_abnormal_blastocyst_morpholog1.21096606
66MP0000534_abnormal_ureter_morphology1.20301358
67MP0000428_abnormal_craniofacial_morphol1.19964677
68MP0002925_abnormal_cardiovascular_devel1.19233418
69MP0008007_abnormal_cellular_replicative1.19055582
70MP0009697_abnormal_copulation1.18663016
71MP0000432_abnormal_head_morphology1.15591618
72MP0001286_abnormal_eye_development1.14860598
73MP0000350_abnormal_cell_proliferation1.14406308
74MP0008775_abnormal_heart_ventricle1.13606078
75MP0003567_abnormal_fetal_cardiomyocyte1.13354307
76MP0003828_pulmonary_edema1.12196033
77MP0002295_abnormal_pulmonary_circulatio1.10868711
78MP0005330_cardiomyopathy1.09923197
79MP0003942_abnormal_urinary_system1.09914760
80MP0009780_abnormal_chondrocyte_physiolo1.08282200
81MP0002249_abnormal_larynx_morphology1.05586691
82MP0009703_decreased_birth_body1.04910501
83MP0000566_synostosis1.04589998
84MP0004197_abnormal_fetal_growth/weight/1.03348547
85MP0000751_myopathy1.03265184
86MP0008057_abnormal_DNA_replication1.02582008
87MP0001614_abnormal_blood_vessel1.01119360
88MP0002697_abnormal_eye_size1.00941949
89MP0005375_adipose_tissue_phenotype1.00510857
90MP0004782_abnormal_surfactant_physiolog1.00344255
91MP0002111_abnormal_tail_morphology1.00261893
92MP0005197_abnormal_uvea_morphology1.00001859
93MP0003221_abnormal_cardiomyocyte_apopto0.97209842
94MP0003718_maternal_effect0.96700645
95MP0002938_white_spotting0.96303131
96MP0000579_abnormal_nail_morphology0.96205717
97MP0002060_abnormal_skin_morphology0.95673526
98MP0001177_atelectasis0.94529037
99MP0000266_abnormal_heart_morphology0.94124671
100MP0002932_abnormal_joint_morphology0.92382728
101MP0002282_abnormal_trachea_morphology0.91053511
102MP0000003_abnormal_adipose_tissue0.90456051
103MP0004484_altered_response_of0.90357595
104MP0010307_abnormal_tumor_latency0.89720786
105MP0003119_abnormal_digestive_system0.89455285
106MP0001544_abnormal_cardiovascular_syste0.89418614
107MP0005385_cardiovascular_system_phenoty0.89418614
108MP0002128_abnormal_blood_circulation0.89337391
109MP0004036_abnormal_muscle_relaxation0.88671837
110MP0005395_other_phenotype0.88410883
111MP0002168_other_aberrant_phenotype0.88172695
112MP0000049_abnormal_middle_ear0.87200708
113MP0000762_abnormal_tongue_morphology0.86828624
114MP0002080_prenatal_lethality0.86770579
115MP0001299_abnormal_eye_distance/0.86750928
116MP0002233_abnormal_nose_morphology0.86516331
117MP0002116_abnormal_craniofacial_bone0.85818278
118MP0008932_abnormal_embryonic_tissue0.85736084
119MP0005620_abnormal_muscle_contractility0.85690913
120MP0000462_abnormal_digestive_system0.83207436
121MP0001879_abnormal_lymphatic_vessel0.82564897
122MP0002108_abnormal_muscle_morphology0.82158494
123MP0005408_hypopigmentation0.80355968
124MP0001784_abnormal_fluid_regulation0.80058058
125MP0002092_abnormal_eye_morphology0.79958318
126MP0002972_abnormal_cardiac_muscle0.79542275
127MP0002796_impaired_skin_barrier0.79157310
128MP0002089_abnormal_postnatal_growth/wei0.78667960

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.31244606
2Protrusio acetabuli (HP:0003179)5.17244253
3Shallow orbits (HP:0000586)4.12824239
4Ankle contracture (HP:0006466)3.85618459
5Cerebral aneurysm (HP:0004944)3.43512008
6Muscle fiber splitting (HP:0003555)3.07038429
7Peritonitis (HP:0002586)3.01183255
8Aortic dissection (HP:0002647)2.99184445
9Genu recurvatum (HP:0002816)2.98612746
10Male infertility (HP:0003251)2.85660354
11Increased connective tissue (HP:0009025)2.82799718
12Shawl scrotum (HP:0000049)2.82274378
13Atrophic scars (HP:0001075)2.74316317
14Wrist flexion contracture (HP:0001239)2.61904222
15Soft skin (HP:0000977)2.53874285
16Bladder diverticulum (HP:0000015)2.52929308
17Mitral valve prolapse (HP:0001634)2.45743372
18Cervical subluxation (HP:0003308)2.45294969
19Difficulty climbing stairs (HP:0003551)2.40077866
20Aortic aneurysm (HP:0004942)2.35714254
21Broad metatarsal (HP:0001783)2.32041427
22Hip contracture (HP:0003273)2.29568930
23Ulnar bowing (HP:0003031)2.29477848
24Short humerus (HP:0005792)2.25267268
25Abnormality of dentin (HP:0010299)2.24772822
26Camptodactyly of toe (HP:0001836)2.23990462
27Aneurysm (HP:0002617)2.21158189
28Spinal rigidity (HP:0003306)2.16254345
29Facial hemangioma (HP:0000329)2.15826926
30Choanal stenosis (HP:0000452)2.08688800
31Abnormal delivery (HP:0001787)2.08633999
32Aplasia/hypoplasia of the humerus (HP:0006507)2.07878618
33Osteolytic defects of the hand bones (HP:0009699)2.06082035
34Osteolytic defects of the phalanges of the hand (HP:0009771)2.06082035
35Fragile skin (HP:0001030)2.05542882
36Knee flexion contracture (HP:0006380)2.03702388
37Blue sclerae (HP:0000592)2.03248428
38Hyperextensible skin (HP:0000974)2.02688723
39Papillary thyroid carcinoma (HP:0002895)2.01816379
40Breast hypoplasia (HP:0003187)2.01504840
41Coronal craniosynostosis (HP:0004440)2.01311904
42Hepatoblastoma (HP:0002884)2.01310898
43Arnold-Chiari malformation (HP:0002308)2.00596797
44Vascular tortuosity (HP:0004948)1.98059081
45Spastic diplegia (HP:0001264)1.96687186
46Short nail (HP:0001799)1.96585646
47Scapular winging (HP:0003691)1.96554045
48Hyporeflexia of lower limbs (HP:0002600)1.95481470
49Right ventricular cardiomyopathy (HP:0011663)1.95198709
50Dilatation of the ascending aorta (HP:0005111)1.94730812
51Cortical dysplasia (HP:0002539)1.92771132
52Natal tooth (HP:0000695)1.92382662
53Wormian bones (HP:0002645)1.91965132
54Upper limb amyotrophy (HP:0009129)1.90903711
55Distal upper limb amyotrophy (HP:0007149)1.90903711
56Spinal cord lesions (HP:0100561)1.89753615
57Syringomyelia (HP:0003396)1.89753615
58Bifid tongue (HP:0010297)1.89096241
59Preaxial foot polydactyly (HP:0001841)1.89092184
60Renal duplication (HP:0000075)1.89066468
61Selective tooth agenesis (HP:0001592)1.88451221
62Facial cleft (HP:0002006)1.88271570
63Nephroblastoma (Wilms tumor) (HP:0002667)1.87363996
64Embryonal renal neoplasm (HP:0011794)1.86981531
65Partial duplication of thumb phalanx (HP:0009944)1.86103073
66Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.85997261
67Short 4th metacarpal (HP:0010044)1.85997261
68Asymmetry of the thorax (HP:0001555)1.85035594
69Sparse lateral eyebrow (HP:0005338)1.84989892
70Myelomeningocele (HP:0002475)1.83826011
71Difficulty running (HP:0009046)1.82590673
72Vertebral arch anomaly (HP:0008438)1.82437034
73Increased nuchal translucency (HP:0010880)1.82284901
74Adrenal hypoplasia (HP:0000835)1.81582765
75Hypoplasia of the iris (HP:0007676)1.81376249
76Biconcave vertebral bodies (HP:0004586)1.80976913
77Neonatal short-limb short stature (HP:0008921)1.80874465
78Broad thumb (HP:0011304)1.80679085
79Skull defect (HP:0001362)1.80156512
80Pterygium (HP:0001059)1.79833165
81Partial duplication of the phalanx of hand (HP:0009999)1.79302472
82Hypoplastic ischia (HP:0003175)1.78864929
83Abnormality of the lacrimal duct (HP:0011481)1.77729222
84Deviation of the hallux (HP:0010051)1.77458328
85Microglossia (HP:0000171)1.76583010
86Abnormality of the distal phalanx of the thumb (HP:0009617)1.75512087
87Fused cervical vertebrae (HP:0002949)1.74468040
88Abnormality of the umbilical cord (HP:0010881)1.74464018
89Duplication of thumb phalanx (HP:0009942)1.73402903
90Abnormality of carpal bone ossification (HP:0006257)1.71600111
91Turricephaly (HP:0000262)1.71235061
92Arterial tortuosity (HP:0005116)1.70933444
93Wide anterior fontanel (HP:0000260)1.70656703
94Hallux valgus (HP:0001822)1.70372032
95Sudden death (HP:0001699)1.70162576
96Short hallux (HP:0010109)1.69650066
97Broad long bones (HP:0005622)1.69488660
98Cardiovascular calcification (HP:0011915)1.68401128
99Abnormality of the nasolacrimal system (HP:0000614)1.67179274
100Advanced eruption of teeth (HP:0006288)1.66678892
101Rib fusion (HP:0000902)1.66353892
102Ventricular tachycardia (HP:0004756)1.66283979
103Bowel diverticulosis (HP:0005222)1.65378104
104Abnormality of the astrocytes (HP:0100707)1.65278477
105Astrocytoma (HP:0009592)1.65278477
106Elbow flexion contracture (HP:0002987)1.64550807
107Breech presentation (HP:0001623)1.64000454
108Buphthalmos (HP:0000557)1.63731493
109Disproportionate tall stature (HP:0001519)1.62498681
110Overgrowth (HP:0001548)1.62428667
111Deep venous thrombosis (HP:0002625)1.61859377
112Aplasia/Hypoplasia of the hallux (HP:0008362)1.61428659
113Limited hip movement (HP:0008800)1.60489670
114Delayed cranial suture closure (HP:0000270)1.60378701
115Wide nose (HP:0000445)1.60232597
116Abnormality of the 4th metacarpal (HP:0010012)1.59861160
117Abnormal ossification of hand bones (HP:0005921)1.59744514
118Abnormality of the labia minora (HP:0012880)1.58692223
119Lymphangioma (HP:0100764)1.56997203
120Gastrointestinal carcinoma (HP:0002672)1.56987217
121Malignant gastrointestinal tract tumors (HP:0006749)1.56987217
122Abnormal lung lobation (HP:0002101)1.56666675
123Deviation of the thumb (HP:0009603)1.55617765
124Abnormal umbilical cord blood vessels (HP:0011403)1.54564620
125Single umbilical artery (HP:0001195)1.54564620
126Abnormality of the fetal cardiovascular system (HP:0010948)1.54564620
127Broad toe (HP:0001837)1.53972475
128Joint laxity (HP:0001388)1.53892846
129Abnormality of the acetabulum (HP:0003170)1.53417104
130Absent eyelashes (HP:0000561)1.53318497
131Broad phalanx (HP:0006009)1.53127873
132Short 1st metacarpal (HP:0010034)1.52640983
133Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.52640983
134Aplasia involving bones of the extremities (HP:0009825)1.52640072
135Aplasia involving bones of the upper limbs (HP:0009823)1.52640072
136Aplasia of the phalanges of the hand (HP:0009802)1.52640072
137Omphalocele (HP:0001539)1.51872561
138Broad hallux (HP:0010055)1.51853462
139Aplasia/Hypoplasia of the breasts (HP:0010311)1.51805226
140Tracheal stenosis (HP:0002777)1.51801947
141Tibial bowing (HP:0002982)1.51488549
142Subacute progressive viral hepatitis (HP:0006572)1.51286237
143Venous abnormality (HP:0002624)1.50696569
144Atrial fibrillation (HP:0005110)1.50662063
145Absent eyebrow (HP:0002223)1.50597991
146Bowing of the arm (HP:0006488)1.50320945
147Bowed forearm bones (HP:0003956)1.50320945
148Ependymoma (HP:0002888)1.49570839
149Protruding ear (HP:0000411)1.48616824
150Hypoalphalipoproteinemia (HP:0003233)1.48464254
151Cutaneous finger syndactyly (HP:0010554)1.48382324
152Rhizomelia (HP:0008905)1.48239607
153Cutaneous syndactyly (HP:0012725)1.48169846
154Chromosomal breakage induced by crosslinking agents (HP:0003221)1.47635919
155Impaired pain sensation (HP:0007328)1.47574292
156Abnormality of pain sensation (HP:0010832)1.47574292

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS16.41386613
2LATS25.16490579
3STK38L4.27981249
4PBK2.46720986
5STK32.44509008
6TRIB32.40521516
7CDK122.32010379
8TSSK62.28924092
9DDR22.23737719
10TTN2.16768242
11STK381.81423547
12PDGFRA1.81346318
13MYLK1.80682953
14DMPK1.78730941
15PRKD31.74746111
16NEK21.69977710
17MST1R1.63491782
18TTK1.62386842
19TYRO31.58881537
20BRSK21.56853186
21FGFR11.55838313
22SRPK11.55749221
23PLK31.55295249
24MKNK11.52417890
25CDC71.52169493
26PKN21.48841200
27MAP3K61.48283288
28EPHA21.47071414
29ERBB41.39106831
30MKNK21.35050601
31TNIK1.29364088
32EEF2K1.26771314
33PDK31.25849530
34PDK41.25849530
35ICK1.25259185
36KSR21.23424617
37PAK21.23120156
38EPHB21.22347870
39TAOK11.19864862
40PTK21.19861183
41NEK91.19690537
42PAK61.19282559
43FGFR41.18263674
44ABL21.14144859
45MET1.11862516
46MTOR1.11600907
47FGFR21.11079694
48PDGFRB1.10925129
49BMX1.07631548
50MOS1.06189957
51PAK41.05905030
52BRD41.02704704
53TIE11.02581077
54AKT31.02016082
55MAP3K101.00460530
56CHEK21.00398419
57STK390.99833898
58STK100.98104663
59WNK40.97390626
60TAF10.97011159
61CAMK1D0.96909098
62PRKD20.96372500
63PAK30.95446161
64PDK20.95341488
65TGFBR20.92254224
66NEK10.90077351
67RIPK10.87045763
68EIF2AK10.84047378
69RAF10.83682643
70FLT30.83671416
71PTK2B0.82462835
72CDK70.80297523
73MST40.77046176
74PLK40.76533226
75SMG10.76524056
76CDK80.75645210
77CAMK1G0.75596234
78TRPM70.74569254
79EIF2AK30.73564079
80MAP3K80.72311501
81BCR0.72109185
82PLK10.71933798
83FER0.71582387
84WNK10.69575048
85STK240.69429377
86ILK0.66829222
87WEE10.66597527
88BRSK10.65807772
89SCYL20.64821646
90MELK0.64660991
91CDK40.60101426
92MARK20.60090421
93RET0.57673824
94CHEK10.57346286
95CDK90.57318450
96AURKB0.55224406
97EIF2AK20.54977585
98ROCK10.53910537
99MAP3K90.51361686
100LIMK10.50883620
101PNCK0.49057447
102RPS6KB20.48753691
103PRKD10.47752948
104STK40.47432480
105LRRK20.47251887
106PAK10.46902853
107CDK10.45899463
108AKT20.44846682
109PRKAA20.44505188
110NLK0.44035433
111MAP3K120.43322695
112ATM0.42770749
113GSK3A0.41972408
114CDK60.41553719
115PTK60.40591504
116PRKAA10.40463395
117DYRK20.40149300
118PRKDC0.39951268
119PRKCI0.39872917
120ROCK20.39751024
121PLK20.39306556
122YES10.39080851
123OXSR10.39080620
124ATR0.37276617
125KSR10.36367680
126LMTK20.36096313
127ABL10.36092685
128PIK3CA0.34653789
129CLK10.34397621
130WNK30.33897457
131CSNK1G10.33873062
132NTRK10.33730456
133CDK20.33708569
134MAP2K10.33447545
135MAPKAPK30.32843415
136NUAK10.32252083
137MAPK100.31717434
138ALK0.30944350
139BUB10.30771263
140AURKA0.29577780
141CSNK1E0.28721012

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.88346641
2Hippo signaling pathway_Homo sapiens_hsa043902.59227849
3Adherens junction_Homo sapiens_hsa045202.47474821
4TGF-beta signaling pathway_Homo sapiens_hsa043502.41163473
5Focal adhesion_Homo sapiens_hsa045102.38280474
6MicroRNAs in cancer_Homo sapiens_hsa052062.10969785
7Small cell lung cancer_Homo sapiens_hsa052222.09766647
8Cell cycle_Homo sapiens_hsa041102.01487798
9Tight junction_Homo sapiens_hsa045302.01019878
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.94383469
11Basal cell carcinoma_Homo sapiens_hsa052171.88890034
12Hedgehog signaling pathway_Homo sapiens_hsa043401.85462918
13Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.85048251
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.80798955
15Bladder cancer_Homo sapiens_hsa052191.79750938
16Proteoglycans in cancer_Homo sapiens_hsa052051.78694678
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.78607388
18p53 signaling pathway_Homo sapiens_hsa041151.78516653
19Mismatch repair_Homo sapiens_hsa034301.76876955
20Vitamin B6 metabolism_Homo sapiens_hsa007501.76220099
21Dilated cardiomyopathy_Homo sapiens_hsa054141.75334899
22DNA replication_Homo sapiens_hsa030301.69012121
23Selenocompound metabolism_Homo sapiens_hsa004501.63889266
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.61792523
25Non-homologous end-joining_Homo sapiens_hsa034501.60105902
26Dorso-ventral axis formation_Homo sapiens_hsa043201.53585396
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.53348254
28RNA transport_Homo sapiens_hsa030131.50048139
29Regulation of actin cytoskeleton_Homo sapiens_hsa048101.49191214
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.47200770
31Renal cell carcinoma_Homo sapiens_hsa052111.45469421
32One carbon pool by folate_Homo sapiens_hsa006701.41272968
33Amoebiasis_Homo sapiens_hsa051461.41159993
34Pyruvate metabolism_Homo sapiens_hsa006201.39806571
35mTOR signaling pathway_Homo sapiens_hsa041501.39284456
36Complement and coagulation cascades_Homo sapiens_hsa046101.38101487
37Pancreatic cancer_Homo sapiens_hsa052121.36429520
38Oocyte meiosis_Homo sapiens_hsa041141.34362601
39Lysine degradation_Homo sapiens_hsa003101.33758862
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.28567753
41Steroid biosynthesis_Homo sapiens_hsa001001.28347562
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.27766531
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27673850
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.26848901
45Protein digestion and absorption_Homo sapiens_hsa049741.25223281
46Melanoma_Homo sapiens_hsa052181.24385158
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22177857
48Ovarian steroidogenesis_Homo sapiens_hsa049131.17973196
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.17469613
50Chronic myeloid leukemia_Homo sapiens_hsa052201.14869704
51Nucleotide excision repair_Homo sapiens_hsa034201.14555505
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13702981
53Wnt signaling pathway_Homo sapiens_hsa043101.13585897
54Longevity regulating pathway - mammal_Homo sapiens_hsa042111.13183655
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12717516
56Thyroid hormone signaling pathway_Homo sapiens_hsa049191.12700917
57Pathways in cancer_Homo sapiens_hsa052001.11994041
58Prostate cancer_Homo sapiens_hsa052151.11248288
59PI3K-Akt signaling pathway_Homo sapiens_hsa041511.10921766
60Thyroid cancer_Homo sapiens_hsa052161.07974089
61Spliceosome_Homo sapiens_hsa030401.07181604
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03503130
63Basal transcription factors_Homo sapiens_hsa030221.03060584
64AMPK signaling pathway_Homo sapiens_hsa041521.01977456
65Glioma_Homo sapiens_hsa052141.01496683
66Rap1 signaling pathway_Homo sapiens_hsa040151.00310246
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.96519796
68Endometrial cancer_Homo sapiens_hsa052130.95824883
69VEGF signaling pathway_Homo sapiens_hsa043700.94287724
70mRNA surveillance pathway_Homo sapiens_hsa030150.93736815
71Viral myocarditis_Homo sapiens_hsa054160.93450130
72Notch signaling pathway_Homo sapiens_hsa043300.93438351
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90238118
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.89478721
75Choline metabolism in cancer_Homo sapiens_hsa052310.87282054
76RNA degradation_Homo sapiens_hsa030180.86609166
77Colorectal cancer_Homo sapiens_hsa052100.86527531
78Propanoate metabolism_Homo sapiens_hsa006400.86169431
79Axon guidance_Homo sapiens_hsa043600.85951143
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.85642509
81HIF-1 signaling pathway_Homo sapiens_hsa040660.83217662
82Nitrogen metabolism_Homo sapiens_hsa009100.82654890
83Biosynthesis of amino acids_Homo sapiens_hsa012300.81749045
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80842274
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80145264
86ErbB signaling pathway_Homo sapiens_hsa040120.78963110
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78362222
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75686661
89Arginine biosynthesis_Homo sapiens_hsa002200.74929030
90Ras signaling pathway_Homo sapiens_hsa040140.74529731
91Fanconi anemia pathway_Homo sapiens_hsa034600.74131598
92Melanogenesis_Homo sapiens_hsa049160.74002968
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73480038
94Fatty acid biosynthesis_Homo sapiens_hsa000610.73090749
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71791981
96N-Glycan biosynthesis_Homo sapiens_hsa005100.70358499
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.70174718
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69380106
99Galactose metabolism_Homo sapiens_hsa000520.68274004
100Estrogen signaling pathway_Homo sapiens_hsa049150.68199598
101Fatty acid degradation_Homo sapiens_hsa000710.67677085
102Non-small cell lung cancer_Homo sapiens_hsa052230.66530503
103FoxO signaling pathway_Homo sapiens_hsa040680.66238792
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65488404
105HTLV-I infection_Homo sapiens_hsa051660.65157342
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62220532
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61776978
108Glucagon signaling pathway_Homo sapiens_hsa049220.59749781
109Shigellosis_Homo sapiens_hsa051310.59390764
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.58776603
111GnRH signaling pathway_Homo sapiens_hsa049120.58044661
112Circadian rhythm_Homo sapiens_hsa047100.57409160
113Prion diseases_Homo sapiens_hsa050200.57008506
114Platelet activation_Homo sapiens_hsa046110.56406070
115Vitamin digestion and absorption_Homo sapiens_hsa049770.56288189
116Fatty acid metabolism_Homo sapiens_hsa012120.55933652
117Endocytosis_Homo sapiens_hsa041440.54891289
118Gap junction_Homo sapiens_hsa045400.53581995
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53116960
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.52267539
121Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51495836
122Insulin signaling pathway_Homo sapiens_hsa049100.50786531
123Proteasome_Homo sapiens_hsa030500.50169656
124Pentose phosphate pathway_Homo sapiens_hsa000300.49557813
125Folate biosynthesis_Homo sapiens_hsa007900.49544185
126Phenylalanine metabolism_Homo sapiens_hsa003600.48496232
127cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48130305
128Arginine and proline metabolism_Homo sapiens_hsa003300.47259396
129Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47152462
130Carbon metabolism_Homo sapiens_hsa012000.46856013
131Glutathione metabolism_Homo sapiens_hsa004800.46778438
132Tyrosine metabolism_Homo sapiens_hsa003500.46577463
133Thyroid hormone synthesis_Homo sapiens_hsa049180.46080161
134Homologous recombination_Homo sapiens_hsa034400.45963994
135Base excision repair_Homo sapiens_hsa034100.45904238
136Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45789033
137RNA polymerase_Homo sapiens_hsa030200.44951782
138alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44865583
139Insulin resistance_Homo sapiens_hsa049310.44683250
140MAPK signaling pathway_Homo sapiens_hsa040100.43320677
141Fatty acid elongation_Homo sapiens_hsa000620.42296053
142Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42137961
143Viral carcinogenesis_Homo sapiens_hsa052030.39414402
144PPAR signaling pathway_Homo sapiens_hsa033200.37825641
145Ether lipid metabolism_Homo sapiens_hsa005650.36257507
146Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35466713

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