WWC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WWC family of proteins, which also includes the WWC1 (KIBRA) gene product and the WWC2 gene product. The protein encoded by this gene includes a C2 domain, which is known to mediate homodimerization in the related WWC1 gene product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.24445089
2negative regulation of cell killing (GO:0031342)3.79964591
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.79964591
4positive regulation by symbiont of host defense response (GO:0052509)3.70768877
5modulation by symbiont of host defense response (GO:0052031)3.70768877
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.70768877
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.70768877
8positive regulation by organism of defense response of other organism involved in symbiotic interact3.70768877
9modulation by symbiont of host immune response (GO:0052553)3.70768877
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.46382197
11detection of molecule of bacterial origin (GO:0032490)3.23946267
12detection of other organism (GO:0098543)3.21561139
13positive regulation of Cdc42 GTPase activity (GO:0043089)3.16571533
14antigen processing and presentation of endogenous antigen (GO:0019883)3.08790255
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.07823828
16positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.07654814
17positive regulation of gamma-delta T cell activation (GO:0046645)3.06501527
18macrophage activation involved in immune response (GO:0002281)3.00669230
19protein localization to endosome (GO:0036010)2.98772303
20detection of bacterium (GO:0016045)2.95740181
21detection of external biotic stimulus (GO:0098581)2.92839240
22negative regulation of erythrocyte differentiation (GO:0045647)2.90788197
23cellular extravasation (GO:0045123)2.85322848
24neutrophil activation involved in immune response (GO:0002283)2.82509263
25insulin-like growth factor receptor signaling pathway (GO:0048009)2.80822025
26positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.77468082
27positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.74546148
28response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.73241040
29response to host (GO:0075136)2.73241040
30response to host defenses (GO:0052200)2.73241040
31positive regulation of receptor recycling (GO:0001921)2.71028924
32regulation of B cell receptor signaling pathway (GO:0050855)2.65081944
33surfactant homeostasis (GO:0043129)2.64649620
34regulation of gamma-delta T cell activation (GO:0046643)2.64472716
35response to laminar fluid shear stress (GO:0034616)2.64015753
36positive regulation of blood vessel endothelial cell migration (GO:0043536)2.61402576
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.59521866
38response to host immune response (GO:0052572)2.59521866
39stress fiber assembly (GO:0043149)2.58245060
40antigen processing and presentation via MHC class Ib (GO:0002475)2.57730332
41regulation of interferon-beta biosynthetic process (GO:0045357)2.55607755
42detection of biotic stimulus (GO:0009595)2.53068080
43growth hormone receptor signaling pathway (GO:0060396)2.52834340
44JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.52044996
45production of molecular mediator involved in inflammatory response (GO:0002532)2.49479260
46germinal center formation (GO:0002467)2.48722477
47adherens junction assembly (GO:0034333)2.48395061
48leukocyte aggregation (GO:0070486)2.47756695
49histone H3-K36 demethylation (GO:0070544)2.47741193
50regulation of gamma-delta T cell differentiation (GO:0045586)2.45274867
51cell-substrate adherens junction assembly (GO:0007045)2.45070642
52focal adhesion assembly (GO:0048041)2.45070642
53regulation of T-helper 2 cell differentiation (GO:0045628)2.44612855
54response to peptidoglycan (GO:0032494)2.44211735
55ear development (GO:0043583)2.41075526
56regulation of macrophage cytokine production (GO:0010935)2.40726342
57neutrophil activation (GO:0042119)2.40534536
58hepatocyte apoptotic process (GO:0097284)2.39881116
59cytoskeletal anchoring at plasma membrane (GO:0007016)2.39668932
60response to interleukin-15 (GO:0070672)2.38857891
61cell-substrate junction assembly (GO:0007044)2.37329595
62regulation of necroptotic process (GO:0060544)2.31876572
63negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.31468046
64embryonic process involved in female pregnancy (GO:0060136)2.29635209
65response to muramyl dipeptide (GO:0032495)2.29442562
66cellular response to growth hormone stimulus (GO:0071378)2.28017469
67regulation of leukocyte degranulation (GO:0043300)2.27381746
68endothelium development (GO:0003158)2.27195420
69barbed-end actin filament capping (GO:0051016)2.27119304
70maternal placenta development (GO:0001893)2.27057766
71macrophage activation (GO:0042116)2.26229271
72vascular endothelial growth factor signaling pathway (GO:0038084)2.25462739
73interferon-gamma secretion (GO:0072643)2.24874784
74positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.24606864
75leukocyte migration involved in inflammatory response (GO:0002523)2.23199327
76negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.22005715
77negative regulation of anoikis (GO:2000811)2.20915645
78regulation of Cdc42 GTPase activity (GO:0043088)2.20412742
79granulocyte activation (GO:0036230)2.20183604
80positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.20010155
81negative regulation of interleukin-12 production (GO:0032695)2.19884725
82B cell receptor signaling pathway (GO:0050853)2.19836150
83epithelial cell differentiation involved in prostate gland development (GO:0060742)2.19582254
84regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.19169339
85atrioventricular valve morphogenesis (GO:0003181)2.18072288
86hypotonic response (GO:0006971)2.17759263
87peptidyl-tyrosine autophosphorylation (GO:0038083)2.13978066
88response to interferon-alpha (GO:0035455)2.12991954
89negative regulation of protein localization to plasma membrane (GO:1903077)2.12772920
90epithelial cell-cell adhesion (GO:0090136)2.12660598
91negative regulation of lymphocyte mediated immunity (GO:0002707)2.12327993
92thymic T cell selection (GO:0045061)2.11938317
93regulation of histone H3-K27 methylation (GO:0061085)2.11756166
94regulation of mast cell degranulation (GO:0043304)2.11003189
95negative regulation of T-helper cell differentiation (GO:0045623)2.10979601
96negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.10979601
97positive regulation of histone deacetylation (GO:0031065)2.10757237
98planar cell polarity pathway involved in neural tube closure (GO:0090179)2.10036027
99cellular response to virus (GO:0098586)2.09526060
100cellular response to interleukin-15 (GO:0071350)2.08841780

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.21710134
2ESR1_20079471_ChIP-ChIP_T-47D_Human3.11723717
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.89514888
4* ESR2_21235772_ChIP-Seq_MCF-7_Human2.61027939
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.56257062
6* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.45361820
7GATA1_22025678_ChIP-Seq_K562_Human2.43445403
8KDM2B_26808549_Chip-Seq_SUP-B15_Human2.41258978
9TCF7_22412390_ChIP-Seq_EML_Mouse2.18795512
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.18393439
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.13460160
12TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.06022177
13ELK3_25401928_ChIP-Seq_HUVEC_Human2.04488139
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.03762433
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03251659
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.00706447
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98658467
18GATA2_21666600_ChIP-Seq_HMVEC_Human1.95219311
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.92136252
20IRF8_22096565_ChIP-ChIP_GC-B_Human1.89754440
21KDM2B_26808549_Chip-Seq_DND41_Human1.87131443
22EGR1_19374776_ChIP-ChIP_THP-1_Human1.85814056
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.85798985
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.82216348
25KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.80691898
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.79744255
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.77219797
28RACK7_27058665_Chip-Seq_MCF-7_Human1.75123284
29SPI1_23127762_ChIP-Seq_K562_Human1.70912255
30VDR_24763502_ChIP-Seq_THP-1_Human1.70540365
31STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.70029724
32SCL_19346495_ChIP-Seq_HPC-7_Human1.69962933
33MYC_22102868_ChIP-Seq_BL_Human1.69414736
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.68599855
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.67980663
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.66724808
37VDR_21846776_ChIP-Seq_THP-1_Human1.65764519
38RUNX_20019798_ChIP-Seq_JUKART_Human1.65072682
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.63430420
40TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60345970
41FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.59563934
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53090819
43GATA1_19941826_ChIP-Seq_K562_Human1.53080564
44RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.53070331
45SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.53030886
46SOX9_24532713_ChIP-Seq_HFSC_Mouse1.50535709
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.50437329
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49717487
49GATA1_19941827_ChIP-Seq_MEL_Mouse1.49448919
50KDM2B_26808549_Chip-Seq_K562_Human1.49088577
51TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.48259491
52KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.47850553
53FOXO3_23340844_ChIP-Seq_DLD1_Human1.46567149
54TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45798234
55AHR_22903824_ChIP-Seq_MCF-7_Human1.44893490
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44767521
57IRF8_21731497_ChIP-ChIP_J774_Mouse1.41744749
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.41602705
59CLOCK_20551151_ChIP-Seq_293T_Human1.40753517
60WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39757054
61KDM2B_26808549_Chip-Seq_JURKAT_Human1.39407101
62RUNX1_22412390_ChIP-Seq_EML_Mouse1.38505124
63MAF_26560356_Chip-Seq_TH1_Human1.38409407
64EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.37768324
65TBX20_22328084_ChIP-Seq_HEART_Mouse1.36355478
66TBX20_22080862_ChIP-Seq_HEART_Mouse1.36355478
67KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35524613
68RUNX1_27514584_Chip-Seq_MCF-7_Human1.32682731
69SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.32374475
70SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.32374475
71* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28178648
72LXR_22292898_ChIP-Seq_THP-1_Human1.26655826
73ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.26630722
74DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.24393153
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24072789
76TRIM28_21343339_ChIP-Seq_HEK293_Human1.23206385
77SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.22176989
78SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22119021
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19570599
80PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18150100
81UTX_26944678_Chip-Seq_JUKART_Human1.16792427
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.14815147
83GATA2_19941826_ChIP-Seq_K562_Human1.13130013
84RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12902441
85VDR_24787735_ChIP-Seq_THP-1_Human1.10210651
86* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09586925
87PU_27001747_Chip-Seq_BMDM_Mouse1.06235757
88WT1_19549856_ChIP-ChIP_CCG9911_Human1.05894755
89NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04695501
90EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04245095
91ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02782661
92ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02618085
93GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00215740
94FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00129117
95CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00080310
96IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.96804594
97ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96189925
98NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95223579
99CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94200229
100GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94079601

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.39361014
2MP0002254_reproductive_system_inflammat3.02436579
3MP0003724_increased_susceptibility_to2.99005332
4MP0003566_abnormal_cell_adhesion2.90305868
5MP0003191_abnormal_cellular_cholesterol2.84739257
6MP0003300_gastrointestinal_ulcer2.77154984
7MP0003303_peritoneal_inflammation2.37577722
8MP0001958_emphysema2.32990852
9MP0008438_abnormal_cutaneous_collagen2.27164569
10MP0003828_pulmonary_edema2.04348435
11MP0003091_abnormal_cell_migration2.02801314
12MP0003436_decreased_susceptibility_to1.94242710
13MP0005083_abnormal_biliary_tract1.87543011
14MP0005248_abnormal_Harderian_gland1.86430872
15MP0010234_abnormal_vibrissa_follicle1.84514808
16MP0005409_darkened_coat_color1.81184005
17MP0005275_abnormal_skin_tensile1.80730995
18MP0008260_abnormal_autophagy1.80361457
19MP0005076_abnormal_cell_differentiation1.72683557
20MP0004264_abnormal_extraembryonic_tissu1.72199190
21MP0004272_abnormal_basement_membrane1.68598827
22MP0000767_abnormal_smooth_muscle1.68286527
23MP0004381_abnormal_hair_follicle1.66422431
24MP0003045_fibrosis1.62287918
25MP0005451_abnormal_body_composition1.60961720
26MP0004510_myositis1.60710030
27MP0003279_aneurysm1.54318665
28MP0003763_abnormal_thymus_physiology1.53787685
29MP0004947_skin_inflammation1.51274806
30MP0008004_abnormal_stomach_pH1.50920431
31MP0002419_abnormal_innate_immunity1.48810399
32MP0001849_ear_inflammation1.48132511
33MP0002796_impaired_skin_barrier1.47042938
34MP0001533_abnormal_skeleton_physiology1.46807978
35MP0002877_abnormal_melanocyte_morpholog1.45772811
36MP0010352_gastrointestinal_tract_polyps1.43623746
37MP0002396_abnormal_hematopoietic_system1.40294072
38MP0010368_abnormal_lymphatic_system1.39884158
39MP0000685_abnormal_immune_system1.33023018
40MP0003453_abnormal_keratinocyte_physiol1.32388336
41MP0004883_abnormal_blood_vessel1.30884797
42MP0001835_abnormal_antigen_presentation1.30216198
43MP0005023_abnormal_wound_healing1.28568385
44MP0000858_altered_metastatic_potential1.28467589
45MP0005464_abnormal_platelet_physiology1.27945666
46MP0001851_eye_inflammation1.24123506
47MP0001879_abnormal_lymphatic_vessel1.24082486
48MP0002998_abnormal_bone_remodeling1.23410806
49MP0005025_abnormal_response_to1.20840699
50MP0003183_abnormal_peptide_metabolism1.20838159
51MP0001790_abnormal_immune_system1.19740281
52MP0005387_immune_system_phenotype1.19740281
53MP0005377_hearing/vestibular/ear_phenot1.16973377
54MP0003878_abnormal_ear_physiology1.16973377
55MP0006138_congestive_heart_failure1.16549549
56MP0009278_abnormal_bone_marrow1.12868888
57MP0000465_gastrointestinal_hemorrhage1.10823199
58MP0005388_respiratory_system_phenotype1.09152537
59MP0002133_abnormal_respiratory_system1.09152537
60MP0003172_abnormal_lysosome_physiology1.07643092
61MP0002166_altered_tumor_susceptibility1.07564367
62MP0005164_abnormal_response_to1.07461393
63MP0004233_abnormal_muscle_weight1.05265533
64MP0005000_abnormal_immune_tolerance1.04871266
65MP0006054_spinal_hemorrhage1.04667619
66MP0002405_respiratory_system_inflammati1.04643039
67MP0004808_abnormal_hematopoietic_stem1.04232898
68MP0002420_abnormal_adaptive_immunity1.04141763
69MP0001819_abnormal_immune_cell1.03714275
70MP0002168_other_aberrant_phenotype1.02855727
71MP0002452_abnormal_antigen_presenting1.01820593
72MP0001800_abnormal_humoral_immune1.01333467
73MP0010155_abnormal_intestine_physiology1.00343338
74MP0002723_abnormal_immune_serum0.99236604
75MP0004782_abnormal_surfactant_physiolog0.97575839
76MP0004858_abnormal_nervous_system0.94266735
77MP0002060_abnormal_skin_morphology0.92227418
78MP0010630_abnormal_cardiac_muscle0.91615820
79MP0005501_abnormal_skin_physiology0.90639509
80MP0002896_abnormal_bone_mineralization0.90425657
81MP0001915_intracranial_hemorrhage0.87192459
82MP0003941_abnormal_skin_development0.86826922
83MP0002398_abnormal_bone_marrow0.85635046
84MP0002925_abnormal_cardiovascular_devel0.85233835
85MP0009780_abnormal_chondrocyte_physiolo0.84578162
86MP0005390_skeleton_phenotype0.84264056
87MP0003866_abnormal_defecation0.83621872
88MP0003448_altered_tumor_morphology0.83093893
89MP0001873_stomach_inflammation0.82823830
90MP0001346_abnormal_lacrimal_gland0.82780409
91MP0004084_abnormal_cardiac_muscle0.82424996
92MP0004484_altered_response_of0.80306427
93MP0001614_abnormal_blood_vessel0.80076498
94MP0000716_abnormal_immune_system0.79295421
95MP0006082_CNS_inflammation0.79264443
96MP0010030_abnormal_orbit_morphology0.79119037
97MP0003950_abnormal_plasma_membrane0.78695209
98MP0002127_abnormal_cardiovascular_syste0.78271217
99MP0009384_cardiac_valve_regurgitation0.77330860
100MP0003795_abnormal_bone_structure0.76276960

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)3.71383987
2Spontaneous hematomas (HP:0007420)3.10291667
3Arterial tortuosity (HP:0005116)3.06351587
4Peritonitis (HP:0002586)2.95498688
5Vascular tortuosity (HP:0004948)2.90223692
6Aortic aneurysm (HP:0004942)2.88772862
7Aortic dissection (HP:0002647)2.81218979
8Premature rupture of membranes (HP:0001788)2.75749595
9Interstitial pulmonary disease (HP:0006530)2.71454784
10Protrusio acetabuli (HP:0003179)2.70940593
11Dilatation of the ascending aorta (HP:0005111)2.66855059
12Broad face (HP:0000283)2.59566567
13Abnormality of macrophages (HP:0004311)2.57430674
14Osteolytic defects of the hand bones (HP:0009699)2.55582964
15Osteolytic defects of the phalanges of the hand (HP:0009771)2.55582964
16Cervical subluxation (HP:0003308)2.54869382
17Recurrent abscess formation (HP:0002722)2.52067026
18Increased connective tissue (HP:0009025)2.52056180
19Mitral valve prolapse (HP:0001634)2.43257674
20Cerebral aneurysm (HP:0004944)2.40101042
21Distal lower limb muscle weakness (HP:0009053)2.37522768
22Cellulitis (HP:0100658)2.36714674
23Hyporeflexia of lower limbs (HP:0002600)2.36691326
24Right ventricular cardiomyopathy (HP:0011663)2.34374715
25Aneurysm (HP:0002617)2.30194795
26Abnormality of the fingertips (HP:0001211)2.29027578
27Subacute progressive viral hepatitis (HP:0006572)2.27197378
28Increased IgE level (HP:0003212)2.25861679
29Myositis (HP:0100614)2.25703964
30Abnormality of the distal phalanx of the thumb (HP:0009617)2.25601749
31Orchitis (HP:0100796)2.23371868
32Genu recurvatum (HP:0002816)2.23281777
33Absent frontal sinuses (HP:0002688)2.22401634
34Broad metatarsal (HP:0001783)2.21580411
35Flat acetabular roof (HP:0003180)2.20426666
36Gingivitis (HP:0000230)2.18150228
37Gastrointestinal infarctions (HP:0005244)2.17267717
38Menorrhagia (HP:0000132)2.16719040
39Recurrent bacterial skin infections (HP:0005406)2.14622937
40Prolonged bleeding time (HP:0003010)2.11831234
41Abnormal platelet volume (HP:0011876)2.07867914
42Blue sclerae (HP:0000592)2.03270572
43Spondylolisthesis (HP:0003302)2.01596173
44Spinal cord lesions (HP:0100561)2.01286902
45Syringomyelia (HP:0003396)2.01286902
46Obstructive sleep apnea (HP:0002870)2.00695629
47Persistence of primary teeth (HP:0006335)1.98946155
48Shallow orbits (HP:0000586)1.97179913
49Thin bony cortex (HP:0002753)1.92135125
50Increased variability in muscle fiber diameter (HP:0003557)1.90257472
51Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.89917223
52Metaphyseal cupping (HP:0003021)1.88128432
53Muscle fiber splitting (HP:0003555)1.84482031
54Macroorchidism (HP:0000053)1.84052949
55Abnormal vertebral ossification (HP:0100569)1.83553994
56Optic neuritis (HP:0100653)1.82528207
57Retrobulbar optic neuritis (HP:0100654)1.82528207
58Asymmetry of the thorax (HP:0001555)1.81788044
59Epistaxis (HP:0000421)1.81222682
60Atrophic scars (HP:0001075)1.80957115
61Fragile skin (HP:0001030)1.80125989
62Recurrent gram-negative bacterial infections (HP:0005420)1.79558598
63Polycythemia (HP:0001901)1.78969506
64Ventricular tachycardia (HP:0004756)1.78716090
65Overgrowth (HP:0001548)1.78157906
66Joint laxity (HP:0001388)1.76107689
67Chest pain (HP:0100749)1.74505573
68Micronodular cirrhosis (HP:0001413)1.74390927
69Hypochromic microcytic anemia (HP:0004840)1.73341625
70Curly hair (HP:0002212)1.73203235
71Abnormality of skeletal muscle fiber size (HP:0012084)1.73169071
72Gingival bleeding (HP:0000225)1.72802016
73Abnormality of incisor morphology (HP:0011063)1.72489786
74Increased mean platelet volume (HP:0011877)1.72189157
75Osteomyelitis (HP:0002754)1.71956767
76Distal lower limb amyotrophy (HP:0008944)1.71337012
77Hematochezia (HP:0002573)1.71097228
78Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.70705972
79Arterial thrombosis (HP:0004420)1.67836346
80Difficulty running (HP:0009046)1.67783473
81Abnormal delayed hypersensitivity skin test (HP:0002963)1.67006625
82Dislocated radial head (HP:0003083)1.65458965
83Asymmetric septal hypertrophy (HP:0001670)1.64487190
84Microcytic anemia (HP:0001935)1.63544624
85Wormian bones (HP:0002645)1.61519676
86T lymphocytopenia (HP:0005403)1.61390614
87Recurrent fungal infections (HP:0002841)1.59969466
88Esophageal varix (HP:0002040)1.59783279
89Narrow palate (HP:0000189)1.59126367
90Disproportionate tall stature (HP:0001519)1.58630754
91Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.58218886
92Mitral regurgitation (HP:0001653)1.58025940
93Viral hepatitis (HP:0006562)1.57193067
94Severe short stature (HP:0003510)1.55964703
95Abnormality of the frontal sinuses (HP:0002687)1.55833689
96Sparse lateral eyebrow (HP:0005338)1.55033309
97Abnormality of the radial head (HP:0003995)1.53716448
98Abnormality of the distal phalanges of the toes (HP:0010182)1.52441592
99Abnormality of oral frenula (HP:0000190)1.52045224
100Meningitis (HP:0001287)1.51957578

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.60963106
2PRPF4B2.79725207
3EPHB12.76037407
4ERN12.73376819
5TTN2.16566123
6RIPK12.11070027
7MAP2K32.09313270
8SMG12.05112463
9ZAP702.03431406
10PKN21.99290448
11MAP3K31.97707847
12MAP4K11.92250116
13RIPK41.69369464
14CSK1.69229060
15BLK1.68869543
16SIK11.67121867
17CDK121.66098627
18FGFR41.64404305
19MAP3K101.53941506
20TYK21.49970180
21IRAK41.45906155
22MARK21.42887704
23PDGFRA1.42255806
24PTK61.38814341
25PRKD21.38221872
26DMPK1.34539954
27TAOK11.34423462
28LRRK21.30931254
29GRK61.23338727
30CDC42BPA1.23029456
31EPHA21.22978296
32TNK21.18575586
33MYLK1.16561708
34JAK31.16390131
35MAP3K131.14413264
36JAK11.14166881
37FES1.13968814
38HCK1.13137742
39TGFBR21.10775187
40MAP3K11.08361490
41MAP3K61.07718999
42PDGFRB1.06106520
43SGK31.05249072
44MAP3K71.04889510
45STK381.04810363
46EPHA31.04040342
47BTK1.03396262
48ICK0.98749467
49PAK40.97059212
50FGFR30.95506914
51HIPK20.95326040
52TRPM70.93780177
53LATS10.92996375
54MAP3K140.92764774
55RPS6KA20.92608881
56PTK20.91865917
57KSR20.91513982
58SIK30.91020981
59JAK20.90843799
60NLK0.89939859
61MTOR0.88729903
62YES10.87812104
63RET0.87162291
64STK100.83752640
65PTK2B0.82417779
66CAMK1D0.82351994
67TESK10.80367401
68IKBKE0.79500375
69RPS6KL10.78441419
70RPS6KC10.78441419
71NEK90.75632294
72TBK10.75404199
73FER0.74552515
74WNK10.74282746
75MELK0.73962887
76IRAK10.73468666
77MAPK70.70994616
78PRKD10.69658237
79SGK20.68766930
80FGR0.68603511
81TAOK20.65306700
82PDPK10.60456750
83CAMK1G0.59508097
84BMX0.58780988
85TIE10.57996206
86ROCK20.57915880
87CHUK0.57126834
88RPS6KA60.56651798
89NTRK10.56565409
90EEF2K0.53609466
91PRKG20.51940564
92KSR10.51435090
93MAP3K110.51059967
94MAP3K20.50267835
95STK240.48779322
96MAPKAPK20.48273851
97LCK0.47259720
98PIK3CG0.45320222
99PDK10.42439818
100SYK0.41508487

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.85862785
2Acute myeloid leukemia_Homo sapiens_hsa052211.81890582
3Chronic myeloid leukemia_Homo sapiens_hsa052201.81064666
4Osteoclast differentiation_Homo sapiens_hsa043801.79070778
5Leukocyte transendothelial migration_Homo sapiens_hsa046701.73097477
6B cell receptor signaling pathway_Homo sapiens_hsa046621.73039934
7Renal cell carcinoma_Homo sapiens_hsa052111.72902910
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.66953905
9Pancreatic cancer_Homo sapiens_hsa052121.64602045
10Non-small cell lung cancer_Homo sapiens_hsa052231.59286464
11AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.58955629
12Endometrial cancer_Homo sapiens_hsa052131.54919346
13Focal adhesion_Homo sapiens_hsa045101.50575741
14Notch signaling pathway_Homo sapiens_hsa043301.47447570
15Malaria_Homo sapiens_hsa051441.44694274
16Platelet activation_Homo sapiens_hsa046111.38926146
17Leishmaniasis_Homo sapiens_hsa051401.38205329
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.36194678
19Thyroid cancer_Homo sapiens_hsa052161.35672950
20Adherens junction_Homo sapiens_hsa045201.34665945
21VEGF signaling pathway_Homo sapiens_hsa043701.33437289
22Prolactin signaling pathway_Homo sapiens_hsa049171.32534297
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.31614990
24Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.28734801
25Amoebiasis_Homo sapiens_hsa051461.28335439
26Proteoglycans in cancer_Homo sapiens_hsa052051.26715611
27Hepatitis C_Homo sapiens_hsa051601.26511286
28Prostate cancer_Homo sapiens_hsa052151.22068654
29T cell receptor signaling pathway_Homo sapiens_hsa046601.21940392
30Neurotrophin signaling pathway_Homo sapiens_hsa047221.19669074
31Measles_Homo sapiens_hsa051621.19337827
32Toxoplasmosis_Homo sapiens_hsa051451.19159679
33Small cell lung cancer_Homo sapiens_hsa052221.18348147
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.18026978
35Chemokine signaling pathway_Homo sapiens_hsa040621.16409369
36Hepatitis B_Homo sapiens_hsa051611.16226818
37Regulation of actin cytoskeleton_Homo sapiens_hsa048101.14421896
38ECM-receptor interaction_Homo sapiens_hsa045121.11919734
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.11868888
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.11547389
41Thyroid hormone signaling pathway_Homo sapiens_hsa049191.11185770
42Phospholipase D signaling pathway_Homo sapiens_hsa040721.10840245
43Tuberculosis_Homo sapiens_hsa051521.10775267
44Choline metabolism in cancer_Homo sapiens_hsa052311.07257935
45TNF signaling pathway_Homo sapiens_hsa046681.06458910
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04913073
47Endocytosis_Homo sapiens_hsa041441.03034274
48Colorectal cancer_Homo sapiens_hsa052101.02529232
49ErbB signaling pathway_Homo sapiens_hsa040121.01391297
50Influenza A_Homo sapiens_hsa051641.01299383
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99612086
52FoxO signaling pathway_Homo sapiens_hsa040680.99256381
53Glioma_Homo sapiens_hsa052140.99198646
54Inositol phosphate metabolism_Homo sapiens_hsa005620.97916269
55Dorso-ventral axis formation_Homo sapiens_hsa043200.96777437
56Bladder cancer_Homo sapiens_hsa052190.94064005
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93446870
58Rap1 signaling pathway_Homo sapiens_hsa040150.92785315
59Other glycan degradation_Homo sapiens_hsa005110.90404921
60MicroRNAs in cancer_Homo sapiens_hsa052060.90338729
61mTOR signaling pathway_Homo sapiens_hsa041500.88890704
62Estrogen signaling pathway_Homo sapiens_hsa049150.88867473
63GnRH signaling pathway_Homo sapiens_hsa049120.87683983
64Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86836020
65Dilated cardiomyopathy_Homo sapiens_hsa054140.86575043
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.86242882
67Pathways in cancer_Homo sapiens_hsa052000.85182220
68Insulin resistance_Homo sapiens_hsa049310.83603164
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.82968536
70Apoptosis_Homo sapiens_hsa042100.81887064
71Shigellosis_Homo sapiens_hsa051310.81369790
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79475758
73Insulin signaling pathway_Homo sapiens_hsa049100.78540878
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.77879132
75Staphylococcus aureus infection_Homo sapiens_hsa051500.76375521
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.75989198
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75819572
78Viral myocarditis_Homo sapiens_hsa054160.75647692
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75597738
80HIF-1 signaling pathway_Homo sapiens_hsa040660.71303902
81HTLV-I infection_Homo sapiens_hsa051660.71210565
82African trypanosomiasis_Homo sapiens_hsa051430.69658665
83Phagosome_Homo sapiens_hsa041450.69570432
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.69309146
85MAPK signaling pathway_Homo sapiens_hsa040100.68307355
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.68186521
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68156871
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68044129
89Tight junction_Homo sapiens_hsa045300.66384655
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65165652
91Melanoma_Homo sapiens_hsa052180.63908468
92Salmonella infection_Homo sapiens_hsa051320.63808491
93Ras signaling pathway_Homo sapiens_hsa040140.61981486
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61077556
95Hematopoietic cell lineage_Homo sapiens_hsa046400.60357040
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.60004632
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59352773
98Herpes simplex infection_Homo sapiens_hsa051680.57996400
99Viral carcinogenesis_Homo sapiens_hsa052030.56765753
100Melanogenesis_Homo sapiens_hsa049160.56288489

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