WWOX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)4.60522905
2polyketide metabolic process (GO:0030638)4.35660856
3doxorubicin metabolic process (GO:0044598)4.35660856
4daunorubicin metabolic process (GO:0044597)4.35660856
5inositol phosphate catabolic process (GO:0071545)4.21872494
6detection of light stimulus involved in sensory perception (GO:0050962)4.18327668
7detection of light stimulus involved in visual perception (GO:0050908)4.18327668
8synaptic vesicle endocytosis (GO:0048488)4.07792611
9regulation of rhodopsin mediated signaling pathway (GO:0022400)3.91629535
10regulation of synaptic vesicle exocytosis (GO:2000300)3.91525349
11photoreceptor cell maintenance (GO:0045494)3.88598524
12glutamate secretion (GO:0014047)3.85116294
13nonmotile primary cilium assembly (GO:0035058)3.84078003
14rhodopsin mediated signaling pathway (GO:0016056)3.82625573
15axoneme assembly (GO:0035082)3.82019772
16retinal cone cell development (GO:0046549)3.76781010
17regulation of synaptic vesicle transport (GO:1902803)3.71964053
18phosphorylated carbohydrate dephosphorylation (GO:0046838)3.67136177
19inositol phosphate dephosphorylation (GO:0046855)3.67136177
20lactate metabolic process (GO:0006089)3.66453984
21protein neddylation (GO:0045116)3.64409864
22gamma-aminobutyric acid signaling pathway (GO:0007214)3.63060000
23replication fork processing (GO:0031297)3.58685973
24intraciliary transport (GO:0042073)3.55741378
25regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.50507045
26mitochondrial respiratory chain complex assembly (GO:0033108)3.45606859
27regulation of meiosis I (GO:0060631)3.43461427
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.42151004
29mitochondrial respiratory chain complex I assembly (GO:0032981)3.42151004
30NADH dehydrogenase complex assembly (GO:0010257)3.42151004
31photoreceptor cell development (GO:0042461)3.42094360
32erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.42053073
33L-phenylalanine catabolic process (GO:0006559)3.42053073
34eye photoreceptor cell development (GO:0042462)3.37968131
35positive regulation of histone H3-K4 methylation (GO:0051571)3.37246248
36microtubule severing (GO:0051013)3.36124482
37regulation of short-term neuronal synaptic plasticity (GO:0048172)3.34164423
38synaptic vesicle maturation (GO:0016188)3.33307357
39respiratory chain complex IV assembly (GO:0008535)3.31619182
40G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.31151284
41kinetochore assembly (GO:0051382)3.30349853
42piRNA metabolic process (GO:0034587)3.27602834
43neuronal action potential propagation (GO:0019227)3.23771132
44cerebellar Purkinje cell differentiation (GO:0021702)3.23635689
45negative regulation of synaptic transmission, GABAergic (GO:0032229)3.20190403
46aromatic amino acid family catabolic process (GO:0009074)3.19383621
47branched-chain amino acid catabolic process (GO:0009083)3.17227986
48protein localization to cilium (GO:0061512)3.17008979
49platelet dense granule organization (GO:0060155)3.16989882
50detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.15140587
51indolalkylamine metabolic process (GO:0006586)3.13793719
52regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.13046924
53neuromuscular process controlling posture (GO:0050884)3.12171614
54nucleotide transmembrane transport (GO:1901679)3.11208530
55cytochrome complex assembly (GO:0017004)3.11059875
56axonemal dynein complex assembly (GO:0070286)3.10113276
57retinal rod cell development (GO:0046548)3.09228613
58membrane hyperpolarization (GO:0060081)3.08383280
59GMP metabolic process (GO:0046037)3.07852629
60neurotransmitter uptake (GO:0001504)3.07369704
61retina layer formation (GO:0010842)3.07112609
62regulation of neurotransmitter secretion (GO:0046928)3.06963600
63negative regulation of dendrite morphogenesis (GO:0050774)3.06755354
64synaptic vesicle docking involved in exocytosis (GO:0016081)3.05728782
65vocalization behavior (GO:0071625)3.05533857
66protein polyglutamylation (GO:0018095)3.04620787
67neurotransmitter secretion (GO:0007269)3.03505701
68recombinational repair (GO:0000725)3.03369750
69epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.02905061
70water-soluble vitamin biosynthetic process (GO:0042364)3.01840494
71double-strand break repair via homologous recombination (GO:0000724)3.01734506
72tryptophan metabolic process (GO:0006568)3.01340210
73mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.01087812
74ER overload response (GO:0006983)3.00278879
75DNA double-strand break processing (GO:0000729)2.99257294
76tryptophan catabolic process (GO:0006569)2.99232997
77indole-containing compound catabolic process (GO:0042436)2.99232997
78indolalkylamine catabolic process (GO:0046218)2.99232997
79centriole replication (GO:0007099)2.96328513
80reciprocal DNA recombination (GO:0035825)2.93749259
81reciprocal meiotic recombination (GO:0007131)2.93749259
82aggressive behavior (GO:0002118)2.93693002
83histone H2A acetylation (GO:0043968)2.92413795
84positive regulation of protein homodimerization activity (GO:0090073)2.92354210
85neurotransmitter transport (GO:0006836)2.91858526
86negative regulation of appetite (GO:0032099)2.89216959
87negative regulation of response to food (GO:0032096)2.89216959
88DNA deamination (GO:0045006)2.89059203
89regulation of neurotransmitter transport (GO:0051588)2.88152806
90epithelial cilium movement (GO:0003351)2.87645000
91neurofilament cytoskeleton organization (GO:0060052)2.87619100
92adult walking behavior (GO:0007628)2.86909258
93proteasome assembly (GO:0043248)2.86503428
94L-phenylalanine metabolic process (GO:0006558)2.85330831
95erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.85330831
96L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.85122788
97neuron cell-cell adhesion (GO:0007158)2.84804368
98transferrin transport (GO:0033572)2.82811828
99establishment of synaptic vesicle localization (GO:0097480)2.82675316
100synaptic vesicle transport (GO:0048489)2.82675316
101maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.82399622
102response to pheromone (GO:0019236)2.82133669
103aromatic amino acid family metabolic process (GO:0009072)2.80896287
104synapsis (GO:0007129)2.80564986
105gamma-aminobutyric acid transport (GO:0015812)2.80428598
106xenobiotic catabolic process (GO:0042178)2.79823375
107positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.79121828
108mannosylation (GO:0097502)2.77759396
109protein localization to synapse (GO:0035418)2.77660126
110cellular ketone body metabolic process (GO:0046950)2.76809237
111calcium ion-dependent exocytosis (GO:0017156)2.74480586
112long-term synaptic potentiation (GO:0060291)2.74000076
113resolution of meiotic recombination intermediates (GO:0000712)2.73166964
114transmission of nerve impulse (GO:0019226)2.72416436
115L-methionine salvage (GO:0071267)2.71496103
116L-methionine biosynthetic process (GO:0071265)2.71496103
117amino acid salvage (GO:0043102)2.71496103
118dopamine transport (GO:0015872)2.71227467
119regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.71163205
120cilium movement (GO:0003341)2.71071458
121kinetochore organization (GO:0051383)2.69988373
122positive regulation of mitochondrial fission (GO:0090141)2.69357179
123ferric iron transport (GO:0015682)2.69158073
124trivalent inorganic cation transport (GO:0072512)2.69158073
125photoreceptor cell differentiation (GO:0046530)2.68752408
126eye photoreceptor cell differentiation (GO:0001754)2.68752408
127regulation of acrosome reaction (GO:0060046)2.68107597
128DNA methylation involved in gamete generation (GO:0043046)2.66897964
129regulation of female gonad development (GO:2000194)2.66384497
130dentate gyrus development (GO:0021542)2.65836698
131neuron-neuron synaptic transmission (GO:0007270)2.65584370
132metallo-sulfur cluster assembly (GO:0031163)2.64197285
133iron-sulfur cluster assembly (GO:0016226)2.64197285
134protein K6-linked ubiquitination (GO:0085020)2.63078206
135positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.62978825
136peptidyl-histidine modification (GO:0018202)2.62955482
137startle response (GO:0001964)2.61095367
138synaptic transmission, glutamatergic (GO:0035249)2.60732927
139ketone body metabolic process (GO:1902224)2.58136113
140protein K11-linked deubiquitination (GO:0035871)2.57493456
141acrosome reaction (GO:0007340)2.57227298
142cilium morphogenesis (GO:0060271)2.56904443
143dendrite development (GO:0016358)2.56161330
144amine catabolic process (GO:0009310)2.55811384
145cellular biogenic amine catabolic process (GO:0042402)2.55811384
146male meiosis (GO:0007140)2.55037590
147adenosine metabolic process (GO:0046085)2.54631959
148definitive hemopoiesis (GO:0060216)2.54462551
149seminiferous tubule development (GO:0072520)2.53444338
150establishment of vesicle localization (GO:0051650)2.53129218
151sensory perception of smell (GO:0007608)2.52886953
152kynurenine metabolic process (GO:0070189)2.52335835
153male meiosis I (GO:0007141)2.52240134
154cilium assembly (GO:0042384)2.49500601
155cullin deneddylation (GO:0010388)2.49454045
156branched-chain amino acid metabolic process (GO:0009081)2.48472336
157cilium organization (GO:0044782)2.48462598
158chaperone-mediated protein transport (GO:0072321)2.48006579
159tachykinin receptor signaling pathway (GO:0007217)2.47973019
160methionine metabolic process (GO:0006555)2.47653272
161preassembly of GPI anchor in ER membrane (GO:0016254)2.47388254
162aminoglycoside antibiotic metabolic process (GO:0030647)2.45794890
163cellular potassium ion transport (GO:0071804)2.45320169
164potassium ion transmembrane transport (GO:0071805)2.45320169
165protein complex biogenesis (GO:0070271)2.44344475
166neurotransmitter-gated ion channel clustering (GO:0072578)2.44027061
167regulation of mitochondrial translation (GO:0070129)2.43359064
168striatum development (GO:0021756)2.43331526
169urinary tract smooth muscle contraction (GO:0014848)2.43162336
170regulation of cilium movement (GO:0003352)2.42959432
171meiosis I (GO:0007127)2.42688167
172signal peptide processing (GO:0006465)2.42102211
173C-terminal protein lipidation (GO:0006501)2.40591744
174regulation of neurotransmitter uptake (GO:0051580)2.39269956
175methionine biosynthetic process (GO:0009086)2.36193718
176positive regulation of meiosis (GO:0045836)2.34769643
177short-chain fatty acid metabolic process (GO:0046459)2.33209364
178protein deneddylation (GO:0000338)2.32520006
179mismatch repair (GO:0006298)2.31927262
180DNA replication-dependent nucleosome organization (GO:0034723)2.31542684
181DNA replication-dependent nucleosome assembly (GO:0006335)2.31542684
182negative regulation of heart rate (GO:0010459)2.31320413
183C-terminal protein amino acid modification (GO:0018410)2.30623965

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.38668668
2EZH2_22144423_ChIP-Seq_EOC_Human3.00577278
3TAF15_26573619_Chip-Seq_HEK293_Human2.99956174
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.93164063
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.80461369
6ZNF274_21170338_ChIP-Seq_K562_Hela2.70328716
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.69412891
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.57459027
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42286160
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.40831317
11IGF1R_20145208_ChIP-Seq_DFB_Human2.32442627
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.31516828
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.30782027
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.25476258
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.23980968
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.21523864
17* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.20336467
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.19083020
19VDR_22108803_ChIP-Seq_LS180_Human2.14150224
20REST_21632747_ChIP-Seq_MESCs_Mouse2.08109382
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.04936231
22GABP_17652178_ChIP-ChIP_JURKAT_Human1.98235277
23SMAD4_21799915_ChIP-Seq_A2780_Human1.94618451
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.79231988
25AR_21572438_ChIP-Seq_LNCaP_Human1.78577433
26P300_19829295_ChIP-Seq_ESCs_Human1.78506999
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75291729
28DROSHA_22980978_ChIP-Seq_HELA_Human1.74135988
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73468563
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72946755
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70823522
32* STAT3_23295773_ChIP-Seq_U87_Human1.69806288
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69606865
34* RNF2_27304074_Chip-Seq_NSC_Mouse1.69008999
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.68123413
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.62266041
37* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.60969426
38* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60969426
39* ER_23166858_ChIP-Seq_MCF-7_Human1.60126502
40* VDR_23849224_ChIP-Seq_CD4+_Human1.58992500
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57850306
42BCAT_22108803_ChIP-Seq_LS180_Human1.56285248
43TP53_22573176_ChIP-Seq_HFKS_Human1.56183738
44FUS_26573619_Chip-Seq_HEK293_Human1.54814775
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.52830583
46* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51627865
47REST_18959480_ChIP-ChIP_MESCs_Mouse1.51552910
48EWS_26573619_Chip-Seq_HEK293_Human1.51451136
49* AR_25329375_ChIP-Seq_VCAP_Human1.49724188
50JARID2_20064375_ChIP-Seq_MESCs_Mouse1.49346957
51* CBP_20019798_ChIP-Seq_JUKART_Human1.49247877
52* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49247877
53IRF1_19129219_ChIP-ChIP_H3396_Human1.48889205
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.48808572
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.45988566
56MYC_18940864_ChIP-ChIP_HL60_Human1.45903258
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45105617
58* TCF4_23295773_ChIP-Seq_U87_Human1.44648469
59JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.44057283
60ELK1_19687146_ChIP-ChIP_HELA_Human1.42869394
61EGR1_23403033_ChIP-Seq_LIVER_Mouse1.42312805
62TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.41303184
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41236141
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41164753
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40465794
66* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40389260
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.39323945
68* HTT_18923047_ChIP-ChIP_STHdh_Human1.39184412
69* SMAD3_21741376_ChIP-Seq_EPCs_Human1.38384300
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38056080
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.37855483
72* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36948835
73* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36713201
74P53_22387025_ChIP-Seq_ESCs_Mouse1.35747990
75SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.35172848
76* FOXP3_21729870_ChIP-Seq_TREG_Human1.35071373
77E2F1_18555785_Chip-Seq_ESCs_Mouse1.34601197
78* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.32839629
79SALL1_21062744_ChIP-ChIP_HESCs_Human1.32520510
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31855052
81NANOG_19829295_ChIP-Seq_ESCs_Human1.31596752
82SOX2_19829295_ChIP-Seq_ESCs_Human1.31596752
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31470459
84STAT3_18555785_Chip-Seq_ESCs_Mouse1.31132496
85SUZ12_18555785_Chip-Seq_ESCs_Mouse1.30672084
86CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.29941240
87RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29480251
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27735765
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27021079
90SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.26937794
91* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26057424
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25927769
93FOXA1_25329375_ChIP-Seq_VCAP_Human1.25724125
94FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25724125
95PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25510195
96JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22649086
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21956621
98* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21168204
99P300_18555785_Chip-Seq_ESCs_Mouse1.20846729
100HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20520801
101AR_20517297_ChIP-Seq_VCAP_Human1.20437280
102TCF4_22108803_ChIP-Seq_LS180_Human1.20015423
103RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19665237
104SOX9_26525672_Chip-Seq_HEART_Mouse1.19628708
105* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19239241
106ELF1_17652178_ChIP-ChIP_JURKAT_Human1.19122855
107FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18896898
108CMYC_18555785_Chip-Seq_ESCs_Mouse1.17713264
109MTF2_20144788_ChIP-Seq_MESCs_Mouse1.16967134
110TAL1_26923725_Chip-Seq_HPCs_Mouse1.16270244
111GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15973754
112BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15352840
113EED_16625203_ChIP-ChIP_MESCs_Mouse1.15327907
114RUNX1_27457419_Chip-Seq_LIVER_Mouse1.14952901
115RNF2_18974828_ChIP-Seq_MESCs_Mouse1.14857232
116EZH2_18974828_ChIP-Seq_MESCs_Mouse1.14857232
117KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14828478
118P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14613216
119* RUNX2_22187159_ChIP-Seq_PCA_Human1.14506164
120FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14322778
121NFE2_27457419_Chip-Seq_LIVER_Mouse1.13107204
122ETS1_20019798_ChIP-Seq_JURKAT_Human1.12859043
123HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.12633741
124SOX2_18555785_Chip-Seq_ESCs_Mouse1.12632525
125CRX_20693478_ChIP-Seq_RETINA_Mouse1.12435647
126E2F7_22180533_ChIP-Seq_HELA_Human1.12008996
127* GATA1_26923725_Chip-Seq_HPCs_Mouse1.10814935
128SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10540759
129EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.09481398
130EZH2_27304074_Chip-Seq_ESCs_Mouse1.09074658
131* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08444177
132SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.08265521
133* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07843998
134NMYC_18555785_Chip-Seq_ESCs_Mouse1.06837087
135EZH2_27294783_Chip-Seq_NPCs_Mouse1.06077499
136PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05841642
137RARB_27405468_Chip-Seq_BRAIN_Mouse1.05584002
138RNF2_27304074_Chip-Seq_ESCs_Mouse1.05550510
139HOXB7_26014856_ChIP-Seq_BT474_Human1.04913470
140SMAD4_21741376_ChIP-Seq_EPCs_Human1.04690441
141GATA3_21878914_ChIP-Seq_MCF-7_Human1.04351843
142* PRDM14_20953172_ChIP-Seq_ESCs_Human1.04307604
143* SOX2_21211035_ChIP-Seq_LN229_Gbm1.04272488
144KLF4_18555785_Chip-Seq_ESCs_Mouse1.03302611
145ZFX_18555785_Chip-Seq_ESCs_Mouse1.03209066
146* NCOR_22424771_ChIP-Seq_293T_Human1.02999529
147CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02501556
148NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00590459

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009046_muscle_twitch3.34944317
2MP0001984_abnormal_olfaction3.24125390
3MP0005551_abnormal_eye_electrophysiolog3.10336163
4* MP0005646_abnormal_pituitary_gland2.81911632
5MP0001986_abnormal_taste_sensitivity2.80778961
6MP0003787_abnormal_imprinting2.64435701
7MP0003880_abnormal_central_pattern2.47005510
8MP0003718_maternal_effect2.46313768
9MP0004147_increased_porphyrin_level2.45462597
10MP0003195_calcinosis2.44411389
11MP0003635_abnormal_synaptic_transmissio2.43334732
12MP0004859_abnormal_synaptic_plasticity2.37041961
13MP0002837_dystrophic_cardiac_calcinosis2.36970326
14MP0009745_abnormal_behavioral_response2.32684074
15MP0002272_abnormal_nervous_system2.31793281
16MP0006292_abnormal_olfactory_placode2.31026726
17MP0002064_seizures2.21843630
18MP0001486_abnormal_startle_reflex2.18130551
19MP0004142_abnormal_muscle_tone2.16592128
20MP0005645_abnormal_hypothalamus_physiol2.10170795
21MP0002572_abnormal_emotion/affect_behav2.07438025
22MP0002734_abnormal_mechanical_nocicepti2.05504997
23MP0002638_abnormal_pupillary_reflex2.01304461
24MP0001905_abnormal_dopamine_level1.99416885
25MP0002063_abnormal_learning/memory/cond1.98142102
26MP0008058_abnormal_DNA_repair1.96714717
27MP0005394_taste/olfaction_phenotype1.96356810
28MP0005499_abnormal_olfactory_system1.96356810
29MP0004270_analgesia1.93704175
30MP0001968_abnormal_touch/_nociception1.90561864
31MP0002067_abnormal_sensory_capabilities1.87911025
32MP0006276_abnormal_autonomic_nervous1.85084692
33MP0002735_abnormal_chemical_nociception1.84953039
34MP0001188_hyperpigmentation1.83774957
35MP0009697_abnormal_copulation1.79259426
36MP0010094_abnormal_chromosome_stability1.79067464
37MP0005253_abnormal_eye_physiology1.77008021
38MP0010386_abnormal_urinary_bladder1.73652269
39MP0002653_abnormal_ependyma_morphology1.71468877
40MP0000569_abnormal_digit_pigmentation1.68991887
41MP0003186_abnormal_redox_activity1.68869765
42MP0005423_abnormal_somatic_nervous1.68657997
43MP0002736_abnormal_nociception_after1.68201986
44MP0002229_neurodegeneration1.63969107
45MP0008995_early_reproductive_senescence1.63098344
46MP0001501_abnormal_sleep_pattern1.61811194
47MP0003011_delayed_dark_adaptation1.61751926
48MP0001502_abnormal_circadian_rhythm1.60970270
49MP0003950_abnormal_plasma_membrane1.57919483
50MP0002557_abnormal_social/conspecific_i1.56296496
51MP0001485_abnormal_pinna_reflex1.53356246
52MP0008875_abnormal_xenobiotic_pharmacok1.51591043
53MP0001963_abnormal_hearing_physiology1.49887624
54MP0004134_abnormal_chest_morphology1.48677107
55MP0008789_abnormal_olfactory_epithelium1.45163016
56MP0002184_abnormal_innervation1.42878184
57MP0008877_abnormal_DNA_methylation1.42202053
58MP0003136_yellow_coat_color1.42135382
59MP0005174_abnormal_tail_pigmentation1.39314671
60* MP0000631_abnormal_neuroendocrine_gland1.36284489
61MP0009780_abnormal_chondrocyte_physiolo1.34672854
62MP0006072_abnormal_retinal_apoptosis1.33725904
63MP0008569_lethality_at_weaning1.30972339
64MP0006036_abnormal_mitochondrial_physio1.28883055
65MP0000427_abnormal_hair_cycle1.28441898
66MP0002882_abnormal_neuron_morphology1.25899775
67MP0001970_abnormal_pain_threshold1.23271374
68MP0001324_abnormal_eye_pigmentation1.23254514
69MP0005167_abnormal_blood-brain_barrier1.20753644
70MP0004924_abnormal_behavior1.19255506
71MP0005386_behavior/neurological_phenoty1.19255506
72* MP0001764_abnormal_homeostasis1.17931354
73MP0003121_genomic_imprinting1.17883907
74MP0000383_abnormal_hair_follicle1.15041787
75MP0002090_abnormal_vision1.12176374
76MP0004145_abnormal_muscle_electrophysio1.12101282
77MP0005195_abnormal_posterior_eye1.11799089
78MP0003122_maternal_imprinting1.10173121
79MP0001529_abnormal_vocalization1.10141558
80MP0002752_abnormal_somatic_nervous1.09811375
81MP0003786_premature_aging1.09657955
82* MP0000653_abnormal_sex_gland1.07520201
83MP0002733_abnormal_thermal_nociception1.06686536
84MP0003183_abnormal_peptide_metabolism1.06564911
85MP0002160_abnormal_reproductive_system1.06421678
86MP0000955_abnormal_spinal_cord1.06362687
87MP0000015_abnormal_ear_pigmentation1.04953079
88MP0002066_abnormal_motor_capabilities/c1.03771998
89MP0010329_abnormal_lipoprotein_level1.03573569
90MP0005389_reproductive_system_phenotype1.02729849
91MP0000778_abnormal_nervous_system1.02278212
92MP0005310_abnormal_salivary_gland1.02184102
93MP0004742_abnormal_vestibular_system1.02055476
94* MP0002210_abnormal_sex_determination1.01814731
95MP0002095_abnormal_skin_pigmentation1.00915344
96MP0005647_abnormal_sex_gland1.00845206
97MP0003690_abnormal_glial_cell0.99879344
98MP0002139_abnormal_hepatobiliary_system0.99841442
99MP0005085_abnormal_gallbladder_physiolo0.99234950
100MP0000920_abnormal_myelination0.98780018
101* MP0003698_abnormal_male_reproductive0.98666899
102MP0003806_abnormal_nucleotide_metabolis0.97871942
103MP0004264_abnormal_extraembryonic_tissu0.96632022
104MP0000372_irregular_coat_pigmentation0.95217894
105MP0003633_abnormal_nervous_system0.95196375
106MP0003252_abnormal_bile_duct0.95090797
107MP0005395_other_phenotype0.95030968
108MP0002909_abnormal_adrenal_gland0.94939959
109MP0005075_abnormal_melanosome_morpholog0.94303439
110MP0004811_abnormal_neuron_physiology0.93946698
111MP0005410_abnormal_fertilization0.93399926
112MP0004885_abnormal_endolymph0.91795761
113MP0004043_abnormal_pH_regulation0.91266048
114MP0001440_abnormal_grooming_behavior0.90937219
115MP0003172_abnormal_lysosome_physiology0.90785850
116MP0006035_abnormal_mitochondrial_morpho0.90240941
117MP0004133_heterotaxia0.89922738
118MP0008872_abnormal_physiological_respon0.89256672
119MP0005379_endocrine/exocrine_gland_phen0.88775120
120MP0004233_abnormal_muscle_weight0.87734393
121MP0005084_abnormal_gallbladder_morpholo0.87111096
122MP0006054_spinal_hemorrhage0.87092170
123MP0001756_abnormal_urination0.86635170
124* MP0001145_abnormal_male_reproductive0.86189744
125MP0003879_abnormal_hair_cell0.85941012
126MP0005670_abnormal_white_adipose0.85175494
127MP0002693_abnormal_pancreas_physiology0.85153656
128MP0005220_abnormal_exocrine_pancreas0.84183554
129MP0003890_abnormal_embryonic-extraembry0.83569041
130* MP0000639_abnormal_adrenal_gland0.82280492
131MP0002876_abnormal_thyroid_physiology0.81382427
132* MP0005636_abnormal_mineral_homeostasis0.80801512
133MP0003123_paternal_imprinting0.80591575
134MP0005332_abnormal_amino_acid0.79799999
135MP0003631_nervous_system_phenotype0.78890635
136MP0000026_abnormal_inner_ear0.78085924
137* MP0002152_abnormal_brain_morphology0.77844263
138MP0002102_abnormal_ear_morphology0.73532672
139MP0002938_white_spotting0.72910949
140MP0005391_vision/eye_phenotype0.72336061
141MP0003634_abnormal_glial_cell0.71619264
142MP0002069_abnormal_eating/drinking_beha0.71373007
143MP0001270_distended_abdomen0.71108264
144MP0008057_abnormal_DNA_replication0.71056590
145MP0001929_abnormal_gametogenesis0.70986010

Predicted human phenotypes

RankGene SetZ-score
1Febrile seizures (HP:0002373)4.66146729
2Focal motor seizures (HP:0011153)4.36143878
3Atonic seizures (HP:0010819)4.17281660
4Epileptic encephalopathy (HP:0200134)4.05340231
5Medial flaring of the eyebrow (HP:0010747)4.01597550
6Gait imbalance (HP:0002141)3.82472072
7Nephrogenic diabetes insipidus (HP:0009806)3.72434968
8Congenital primary aphakia (HP:0007707)3.71344857
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.69131712
10Congenital stationary night blindness (HP:0007642)3.43785516
11Pancreatic fibrosis (HP:0100732)3.39657739
12Abnormal respiratory motile cilium physiology (HP:0012261)3.38492760
13Abnormality of macular pigmentation (HP:0008002)3.29917351
14Abnormal ciliary motility (HP:0012262)3.27129005
15Poor coordination (HP:0002370)3.16729907
16Abnormal respiratory epithelium morphology (HP:0012253)3.15894956
17Abnormal respiratory motile cilium morphology (HP:0005938)3.15894956
18Progressive cerebellar ataxia (HP:0002073)3.15375728
19True hermaphroditism (HP:0010459)3.06763179
20Hyperventilation (HP:0002883)3.03674409
21Abnormal hair whorl (HP:0010721)2.92125359
22Absent/shortened dynein arms (HP:0200106)2.86455946
23Dynein arm defect of respiratory motile cilia (HP:0012255)2.86455946
24Methylmalonic acidemia (HP:0002912)2.86163030
25Genetic anticipation (HP:0003743)2.84961665
26Absence seizures (HP:0002121)2.83566162
27Scanning speech (HP:0002168)2.82051952
28Genital tract atresia (HP:0001827)2.81310961
29Bony spicule pigmentary retinopathy (HP:0007737)2.78182660
30Mitochondrial inheritance (HP:0001427)2.77930085
31Vaginal atresia (HP:0000148)2.75624656
32Abnormal rod and cone electroretinograms (HP:0008323)2.73950658
33Increased CSF lactate (HP:0002490)2.71930583
34Retinal dysplasia (HP:0007973)2.65506882
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.63204267
36Chromsome breakage (HP:0040012)2.62131057
37Hyperglycinemia (HP:0002154)2.61605651
38Myokymia (HP:0002411)2.60012361
39Aplasia/Hypoplasia of the fovea (HP:0008060)2.57328376
40Hypoplasia of the fovea (HP:0007750)2.57328376
41Rhinitis (HP:0012384)2.56969338
42Methylmalonic aciduria (HP:0012120)2.55634100
43Nephronophthisis (HP:0000090)2.55337339
44Central scotoma (HP:0000603)2.52786660
45Abnormality of the fovea (HP:0000493)2.48556908
46Renal Fanconi syndrome (HP:0001994)2.48274715
47Chronic hepatic failure (HP:0100626)2.47564141
48Chromosomal breakage induced by crosslinking agents (HP:0003221)2.45360896
49Hypothermia (HP:0002045)2.45083842
50Decreased central vision (HP:0007663)2.39519017
51Aplasia/Hypoplasia of the tibia (HP:0005772)2.39159414
52Meckel diverticulum (HP:0002245)2.38716608
53Hepatic necrosis (HP:0002605)2.37193488
54Focal seizures (HP:0007359)2.36469833
55Molar tooth sign on MRI (HP:0002419)2.35211391
56Abnormality of midbrain morphology (HP:0002418)2.35211391
57Ketosis (HP:0001946)2.34717794
58Tubulointerstitial nephritis (HP:0001970)2.33884086
59Abnormality of the ileum (HP:0001549)2.33860776
60Aplasia/Hypoplasia of the lens (HP:0008063)2.33577360
61Abnormality of the renal medulla (HP:0100957)2.31398594
62Pancreatic cysts (HP:0001737)2.28907184
63Keratoconus (HP:0000563)2.28645658
64Increased corneal curvature (HP:0100692)2.28645658
65Dialeptic seizures (HP:0011146)2.27002470
66Cerebral hypomyelination (HP:0006808)2.25441956
67Abnormality of chromosome stability (HP:0003220)2.24889108
68Ketoacidosis (HP:0001993)2.24322147
69Abnormality of the labia minora (HP:0012880)2.23451958
70Intestinal atresia (HP:0011100)2.23220131
71Degeneration of the lateral corticospinal tracts (HP:0002314)2.22013892
72Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.22013892
73Retinitis pigmentosa (HP:0000510)2.19140603
74Acute necrotizing encephalopathy (HP:0006965)2.18948079
75Protruding tongue (HP:0010808)2.16410361
76Short tibia (HP:0005736)2.16293578
77Microvesicular hepatic steatosis (HP:0001414)2.15906398
78Abnormality of lateral ventricle (HP:0030047)2.15273646
79Abnormal biliary tract physiology (HP:0012439)2.12430246
80Bile duct proliferation (HP:0001408)2.12430246
81EEG with generalized epileptiform discharges (HP:0011198)2.11769021
82Male pseudohermaphroditism (HP:0000037)2.11613994
83Broad foot (HP:0001769)2.11088464
84Epileptiform EEG discharges (HP:0011182)2.09203182
85Abnormal mitochondria in muscle tissue (HP:0008316)2.09164554
86Cerebral edema (HP:0002181)2.08788859
87Abnormality of aromatic amino acid family metabolism (HP:0004338)2.07859441
88Postaxial hand polydactyly (HP:0001162)2.07112633
89Optic disc pallor (HP:0000543)2.07066138
90Postaxial foot polydactyly (HP:0001830)2.06877607
91Menstrual irregularities (HP:0000858)2.06678064
92Abnormality of the renal cortex (HP:0011035)2.06036649
93Septo-optic dysplasia (HP:0100842)2.05536186
94Generalized tonic-clonic seizures (HP:0002069)2.03756188
95Dysdiadochokinesis (HP:0002075)2.02059032
963-Methylglutaconic aciduria (HP:0003535)2.01774141
97Hyperglycinuria (HP:0003108)1.99913742
98Truncal ataxia (HP:0002078)1.99123993
99Poor suck (HP:0002033)1.98119657
100Abnormality of the preputium (HP:0100587)1.97226069
101Generalized aminoaciduria (HP:0002909)1.96634643
102Lipid accumulation in hepatocytes (HP:0006561)1.95644665
103Progressive macrocephaly (HP:0004481)1.94511084
104Aplasia/Hypoplasia of the tongue (HP:0010295)1.93770583
105Lethargy (HP:0001254)1.93740410
106Fetal akinesia sequence (HP:0001989)1.91943647
107Specific learning disability (HP:0001328)1.91886504
108Optic nerve hypoplasia (HP:0000609)1.91821910
109Abnormality of the corticospinal tract (HP:0002492)1.91476914
110Renal cortical cysts (HP:0000803)1.91082204
111Visual hallucinations (HP:0002367)1.89110683
112Type I transferrin isoform profile (HP:0003642)1.88126862
113Hypsarrhythmia (HP:0002521)1.87563537
114Absent speech (HP:0001344)1.86780336
115Dicarboxylic aciduria (HP:0003215)1.85793273
116Abnormality of dicarboxylic acid metabolism (HP:0010995)1.85793273
117Colon cancer (HP:0003003)1.85691484
118Abnormality of vitamin B metabolism (HP:0004340)1.85540100
119Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85391863
120Median cleft lip (HP:0000161)1.84896409
121Abnormality of serine family amino acid metabolism (HP:0010894)1.83543745
122Abnormality of glycine metabolism (HP:0010895)1.83543745
123Attenuation of retinal blood vessels (HP:0007843)1.82546480
124Polydipsia (HP:0001959)1.81553209
125Abnormal drinking behavior (HP:0030082)1.81553209
126Pancreatic islet-cell hyperplasia (HP:0004510)1.81254527
127* Gaze-evoked nystagmus (HP:0000640)1.80306292
128Increased serum lactate (HP:0002151)1.80181163
129Pendular nystagmus (HP:0012043)1.80077886
130Severe visual impairment (HP:0001141)1.79427927
131Lactic acidosis (HP:0003128)1.79186357
132Increased hepatocellular lipid droplets (HP:0006565)1.78898131
133Abolished electroretinogram (ERG) (HP:0000550)1.78683025
134Clubbing of toes (HP:0100760)1.78626668
135Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78285697
136Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.78138031
137Respiratory failure (HP:0002878)1.78038797
138Dysmetria (HP:0001310)1.77756211
139Congenital hepatic fibrosis (HP:0002612)1.77411983
140Impaired vibration sensation in the lower limbs (HP:0002166)1.76904647
141Generalized myoclonic seizures (HP:0002123)1.75765100
142Opisthotonus (HP:0002179)1.75495006
143Sclerocornea (HP:0000647)1.74697419
144Hepatocellular necrosis (HP:0001404)1.73991370
145Glycosuria (HP:0003076)1.73027501
146Abnormality of urine glucose concentration (HP:0011016)1.73027501
147Astigmatism (HP:0000483)1.72162077
148Unsteady gait (HP:0002317)1.72028521
149Urinary bladder sphincter dysfunction (HP:0002839)1.71579012
150Cystic liver disease (HP:0006706)1.71383385
151Acute encephalopathy (HP:0006846)1.70884765
152Abnormal protein glycosylation (HP:0012346)1.70878347
153Abnormal glycosylation (HP:0012345)1.70878347
154Abnormal protein N-linked glycosylation (HP:0012347)1.70878347
155Hypomagnesemia (HP:0002917)1.69563907

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.21403870
2CASK3.43641009
3ZAK3.34794093
4MAP4K23.33144232
5STK163.23386247
6CDK83.18916660
7MST43.04961069
8PRPF4B2.71532303
9MAP2K72.66074330
10AKT32.60033667
11NTRK32.59100969
12SIK32.47221797
13WNK32.11090645
14PRKD32.09392566
15MAP3K42.04072531
16SGK21.96303160
17MAPKAPK51.93453144
18MAPK131.90771194
19EIF2AK31.88377383
20SGK2231.77417091
21SGK4941.77417091
22VRK11.75115835
23BMPR1B1.74166374
24TRIM281.73860865
25ACVR1B1.73303911
26MKNK21.70482266
27BCKDK1.70275463
28NEK61.68583405
29INSRR1.67192214
30TNIK1.62295098
31ERBB31.60882325
32BMPR21.59617703
33PLK21.59607772
34MAP3K131.58969218
35SRPK11.57640345
36TLK11.49526140
37VRK21.47629656
38WNK11.46715767
39MKNK11.40486689
40BRAF1.37777630
41CDK191.37344334
42MAP2K41.36272426
43PINK11.30776152
44PBK1.30348669
45STK391.27848501
46MINK11.26545040
47MUSK1.24486275
48MAP3K121.24302114
49CSNK1G11.24202454
50TXK1.19612431
51CDC71.15343590
52PLK31.13020712
53CSNK1G31.12398935
54TAOK31.10405902
55TEC1.09500545
56SIK21.08597280
57CCNB11.08380641
58RAF11.06359071
59CDK31.05639792
60CAMKK21.05055741
61NME11.03999600
62OXSR11.02353065
63ADRBK20.98064521
64SGK30.96505030
65CSNK1A1L0.96288400
66WNK40.91236809
67BCR0.90834580
68NUAK10.90778369
69CSNK1G20.90086130
70PIM20.86168113
71WEE10.85311246
72PLK10.84850563
73NTRK20.84668565
74PNCK0.83882657
75PRKCG0.80563762
76PDK40.80067246
77PDK30.80067246
78PAK60.78523208
79FGFR20.73881193
80BRSK20.73832626
81BUB10.71839258
82STK38L0.71747486
83KDR0.70841460
84PKN10.68651618
85KIT0.67616280
86ERBB40.67557245
87YES10.66803110
88ARAF0.66323740
89CAMK1G0.65887960
90MAP3K60.65741368
91EPHA40.65188786
92DAPK10.64081257
93DAPK20.63345523
94MAPK120.63196412
95DYRK1A0.62868615
96TRPM70.62809258
97CDK50.62569684
98RPS6KA50.62032102
99HIPK20.61178516
100CAMK2A0.60825363
101MAP3K90.59827802
102TSSK60.57376686
103RPS6KB10.56613907
104GRK10.56404764
105MAPKAPK30.55935095
106GRK50.54933974
107PTK2B0.54244376
108CSNK1A10.53460420
109PRKCQ0.52917958
110EIF2AK10.51970278
111FER0.51965198
112ATR0.51762320
113CSNK1D0.51172443
114GRK70.50526569
115CAMK2G0.50364658
116PRKCE0.48418365
117FES0.48120783
118EIF2AK20.47246473
119RPS6KA20.47230760
120STK30.47166368
121CAMK10.46247037
122ATM0.46188210
123PAK30.45704851
124NEK90.44352678
125STK380.43359595
126PLK40.42887509
127PRKG10.42174202
128MAP2K60.41992316
129PRKCH0.41886553
130IRAK20.41119121
131MAPK70.40405397
132ITK0.39794539
133CAMK40.39076583
134AURKA0.38690221
135FLT30.38371526
136MARK20.38361090
137CAMK2D0.38167833
138PHKG20.38163256
139PHKG10.38163256
140LMTK20.37716423
141ADRBK10.36283022
142MAP3K70.36156961
143PRKACA0.35369435
144CHEK20.35100988
145TTK0.34265711
146MARK30.33098198
147DYRK20.30947922
148PRKCA0.29901807
149PRKCI0.29819223
150PRKACB0.29412638
151CSNK2A10.29311465
152NEK10.28740034
153TIE10.28150832

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.26429934
2Nicotine addiction_Homo sapiens_hsa050333.95361349
3Synaptic vesicle cycle_Homo sapiens_hsa047213.88370699
4GABAergic synapse_Homo sapiens_hsa047272.95249293
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.90514494
6Olfactory transduction_Homo sapiens_hsa047402.81031765
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.74340599
8Collecting duct acid secretion_Homo sapiens_hsa049662.55178342
9Morphine addiction_Homo sapiens_hsa050322.49705358
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.46326080
11Non-homologous end-joining_Homo sapiens_hsa034502.39733195
12Proteasome_Homo sapiens_hsa030502.35421995
13Butanoate metabolism_Homo sapiens_hsa006502.34239702
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.28293707
15Taste transduction_Homo sapiens_hsa047422.21112227
16Primary bile acid biosynthesis_Homo sapiens_hsa001202.06015968
17Circadian entrainment_Homo sapiens_hsa047132.04216065
18Glutamatergic synapse_Homo sapiens_hsa047241.94198138
19Serotonergic synapse_Homo sapiens_hsa047261.84770751
20Oxidative phosphorylation_Homo sapiens_hsa001901.79655084
21Vibrio cholerae infection_Homo sapiens_hsa051101.77986468
22SNARE interactions in vesicular transport_Homo sapiens_hsa041301.73809396
23Protein export_Homo sapiens_hsa030601.73555698
24Caffeine metabolism_Homo sapiens_hsa002321.68470417
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.67042647
26Insulin secretion_Homo sapiens_hsa049111.62178823
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.57335075
28Tryptophan metabolism_Homo sapiens_hsa003801.56684723
29DNA replication_Homo sapiens_hsa030301.50368883
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.49126606
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.47160392
32Dopaminergic synapse_Homo sapiens_hsa047281.44827615
33Basal transcription factors_Homo sapiens_hsa030221.42581594
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.40345655
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.40183166
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.40036099
37Base excision repair_Homo sapiens_hsa034101.37740469
38One carbon pool by folate_Homo sapiens_hsa006701.34790208
39Parkinsons disease_Homo sapiens_hsa050121.32686611
40Circadian rhythm_Homo sapiens_hsa047101.31408489
41Long-term potentiation_Homo sapiens_hsa047201.31295920
42Linoleic acid metabolism_Homo sapiens_hsa005911.30096499
43Nitrogen metabolism_Homo sapiens_hsa009101.28800032
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28457315
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.28260605
46Folate biosynthesis_Homo sapiens_hsa007901.28082297
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27073957
48Cholinergic synapse_Homo sapiens_hsa047251.25659945
49Fatty acid metabolism_Homo sapiens_hsa012121.24832791
50Chemical carcinogenesis_Homo sapiens_hsa052041.21852671
51Fatty acid degradation_Homo sapiens_hsa000711.21426234
52Glutathione metabolism_Homo sapiens_hsa004801.15403507
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13413704
54Nucleotide excision repair_Homo sapiens_hsa034201.12355478
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11795404
56beta-Alanine metabolism_Homo sapiens_hsa004101.10994308
57Amphetamine addiction_Homo sapiens_hsa050311.10725210
58Steroid biosynthesis_Homo sapiens_hsa001001.09418074
59Huntingtons disease_Homo sapiens_hsa050161.08694854
60Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07768713
61Alzheimers disease_Homo sapiens_hsa050101.07398908
62Salivary secretion_Homo sapiens_hsa049701.07222113
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.06247168
64Long-term depression_Homo sapiens_hsa047301.04820717
65Retinol metabolism_Homo sapiens_hsa008301.04693171
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.03760312
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03626692
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03353413
69Vitamin B6 metabolism_Homo sapiens_hsa007501.02549761
70Pentose and glucuronate interconversions_Homo sapiens_hsa000401.00903171
71Pyrimidine metabolism_Homo sapiens_hsa002401.00390699
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99309483
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98408506
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95736243
75Calcium signaling pathway_Homo sapiens_hsa040200.94667790
76Rheumatoid arthritis_Homo sapiens_hsa053230.93779300
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93255492
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92165282
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90836836
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86791569
81Pyruvate metabolism_Homo sapiens_hsa006200.85503389
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84423576
83Purine metabolism_Homo sapiens_hsa002300.82029697
84Ether lipid metabolism_Homo sapiens_hsa005650.80150474
85Gastric acid secretion_Homo sapiens_hsa049710.78776562
86Fructose and mannose metabolism_Homo sapiens_hsa000510.77388529
87Arachidonic acid metabolism_Homo sapiens_hsa005900.76337122
88Oxytocin signaling pathway_Homo sapiens_hsa049210.75350788
89cAMP signaling pathway_Homo sapiens_hsa040240.75343565
90Sulfur metabolism_Homo sapiens_hsa009200.74292775
91Sphingolipid metabolism_Homo sapiens_hsa006000.74164194
92RNA degradation_Homo sapiens_hsa030180.72614011
93Mismatch repair_Homo sapiens_hsa034300.72313005
94RNA transport_Homo sapiens_hsa030130.71567827
95Selenocompound metabolism_Homo sapiens_hsa004500.69649221
96Homologous recombination_Homo sapiens_hsa034400.69389326
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65874060
98Phagosome_Homo sapiens_hsa041450.65388304
99Renin secretion_Homo sapiens_hsa049240.65125038
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.64842568
101Oocyte meiosis_Homo sapiens_hsa041140.62736145
102Fatty acid elongation_Homo sapiens_hsa000620.60882505
103N-Glycan biosynthesis_Homo sapiens_hsa005100.60717713
104Type I diabetes mellitus_Homo sapiens_hsa049400.59343105
105Tyrosine metabolism_Homo sapiens_hsa003500.58577620
106Inositol phosphate metabolism_Homo sapiens_hsa005620.56850392
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.54635925
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53908618
109ErbB signaling pathway_Homo sapiens_hsa040120.52910665
110Cardiac muscle contraction_Homo sapiens_hsa042600.52166706
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51937054
112Cocaine addiction_Homo sapiens_hsa050300.51348099
113Arginine and proline metabolism_Homo sapiens_hsa003300.50892354
114Ovarian steroidogenesis_Homo sapiens_hsa049130.49947338
115Fanconi anemia pathway_Homo sapiens_hsa034600.49469033
116Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48571258
117Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47363987
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47183317
119RNA polymerase_Homo sapiens_hsa030200.45431865
120Lysine degradation_Homo sapiens_hsa003100.45224940
121Pancreatic secretion_Homo sapiens_hsa049720.44921360
122Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43560087
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42902152
124ABC transporters_Homo sapiens_hsa020100.41677443
125Glycerolipid metabolism_Homo sapiens_hsa005610.40219576
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38368521
127Maturity onset diabetes of the young_Homo sapiens_hsa049500.38348476
128Type II diabetes mellitus_Homo sapiens_hsa049300.37803314
129Regulation of autophagy_Homo sapiens_hsa041400.34282743
130Metabolic pathways_Homo sapiens_hsa011000.32857389
131Spliceosome_Homo sapiens_hsa030400.32588953
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.31295737
133Gap junction_Homo sapiens_hsa045400.31217612
134Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30942501
135Ras signaling pathway_Homo sapiens_hsa040140.30653791
136Fat digestion and absorption_Homo sapiens_hsa049750.29390617
137Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.28746944
138Alcoholism_Homo sapiens_hsa050340.28076260
139Propanoate metabolism_Homo sapiens_hsa006400.27937204
140Melanoma_Homo sapiens_hsa052180.27158856
141Colorectal cancer_Homo sapiens_hsa052100.23765010
142Peroxisome_Homo sapiens_hsa041460.23202878
143Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.23024617
144Endometrial cancer_Homo sapiens_hsa052130.22642529
145MAPK signaling pathway_Homo sapiens_hsa040100.21491058
146Galactose metabolism_Homo sapiens_hsa000520.19086274

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