WWP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)5.85633834
2actin-myosin filament sliding (GO:0033275)5.85633834
3L-phenylalanine catabolic process (GO:0006559)5.62431004
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.62431004
5sarcoplasmic reticulum calcium ion transport (GO:0070296)5.35479602
6L-phenylalanine metabolic process (GO:0006558)5.34987650
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.34987650
8response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.10746478
9actin-mediated cell contraction (GO:0070252)5.07632642
10aromatic amino acid family catabolic process (GO:0009074)4.91883388
11lysine catabolic process (GO:0006554)4.81798449
12lysine metabolic process (GO:0006553)4.81798449
13fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.80941698
14skeletal muscle contraction (GO:0003009)4.79058937
15glyoxylate metabolic process (GO:0046487)4.76045281
16alpha-linolenic acid metabolic process (GO:0036109)4.72661167
17cysteine metabolic process (GO:0006534)4.68281600
18triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.65413163
19homocysteine metabolic process (GO:0050667)4.64832852
20skeletal muscle adaptation (GO:0043501)4.51119983
21bile acid biosynthetic process (GO:0006699)4.46480411
22phospholipid homeostasis (GO:0055091)4.42775378
23urea metabolic process (GO:0019627)4.40123944
24urea cycle (GO:0000050)4.40123944
25kynurenine metabolic process (GO:0070189)4.34676339
26indolalkylamine catabolic process (GO:0046218)4.32819613
27tryptophan catabolic process (GO:0006569)4.32819613
28indole-containing compound catabolic process (GO:0042436)4.32819613
29complement activation, alternative pathway (GO:0006957)4.31295409
30tryptophan metabolic process (GO:0006568)4.25415966
31sarcomere organization (GO:0045214)4.22562514
32sulfur amino acid catabolic process (GO:0000098)4.21941604
33actin filament-based movement (GO:0030048)4.21151427
34peptidyl-glutamic acid carboxylation (GO:0017187)4.21016072
35protein carboxylation (GO:0018214)4.21016072
36glycogen catabolic process (GO:0005980)4.08964345
37amino-acid betaine metabolic process (GO:0006577)4.08256905
38regulation of protein activation cascade (GO:2000257)4.04961194
39nitrogen cycle metabolic process (GO:0071941)3.97706372
40fatty acid transmembrane transport (GO:1902001)3.97701919
41cellular ketone body metabolic process (GO:0046950)3.96628731
42serine family amino acid catabolic process (GO:0009071)3.92328190
43bile acid metabolic process (GO:0008206)3.90352231
44negative regulation of fibrinolysis (GO:0051918)3.89588986
45regulation of complement activation (GO:0030449)3.86252137
46glucan catabolic process (GO:0009251)3.83491204
47dicarboxylic acid biosynthetic process (GO:0043650)3.82412870
48positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.81895842
49plasma lipoprotein particle clearance (GO:0034381)3.79657681
50response to muscle activity (GO:0014850)3.77600241
51high-density lipoprotein particle remodeling (GO:0034375)3.77115507
52regulation of skeletal muscle contraction (GO:0014819)3.76340897
53regulation of triglyceride catabolic process (GO:0010896)3.74299990
54fatty acid beta-oxidation (GO:0006635)3.72294214
55negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.71403514
56short-chain fatty acid metabolic process (GO:0046459)3.70503242
57NADH metabolic process (GO:0006734)3.69765202
58myofibril assembly (GO:0030239)3.68715110
592-oxoglutarate metabolic process (GO:0006103)3.68323553
60cellular polysaccharide catabolic process (GO:0044247)3.67181983
61striated muscle contraction (GO:0006941)3.67155273
62drug catabolic process (GO:0042737)3.65621847
63striated muscle atrophy (GO:0014891)3.65602586
64phospholipid efflux (GO:0033700)3.63973667
65carnitine shuttle (GO:0006853)3.63298938
66cellular glucuronidation (GO:0052695)3.62525934
67regulation of fibrinolysis (GO:0051917)3.62437978
68positive regulation of fatty acid beta-oxidation (GO:0032000)3.59939733
69aspartate family amino acid catabolic process (GO:0009068)3.59529115
70reverse cholesterol transport (GO:0043691)3.59378759
71alpha-amino acid catabolic process (GO:1901606)3.59269423
72regulation of sequestering of triglyceride (GO:0010889)3.58059218
73regulation of relaxation of muscle (GO:1901077)3.57272147
74cardiac muscle hypertrophy (GO:0003300)3.55067149
75fatty acid oxidation (GO:0019395)3.54982943
76tyrosine metabolic process (GO:0006570)3.53996564
77creatine metabolic process (GO:0006600)3.52648695
78glutamate metabolic process (GO:0006536)3.51355054
79drug transmembrane transport (GO:0006855)3.50831126
80lipid oxidation (GO:0034440)3.49050702
81acetyl-CoA metabolic process (GO:0006084)3.48474681
82cellular modified amino acid catabolic process (GO:0042219)3.47696769
83valine metabolic process (GO:0006573)3.47603962
84cholesterol efflux (GO:0033344)3.46553821
85aromatic amino acid family metabolic process (GO:0009072)3.46338735
86bundle of His cell to Purkinje myocyte communication (GO:0086069)3.44715145
87acylglycerol homeostasis (GO:0055090)3.44359999
88triglyceride homeostasis (GO:0070328)3.44359999
89cellular amino acid catabolic process (GO:0009063)3.42215520
90ethanol oxidation (GO:0006069)3.41545871
91ketone body metabolic process (GO:1902224)3.40300007
92striated muscle adaptation (GO:0014888)3.39616565
93fatty acid catabolic process (GO:0009062)3.38823203
94regulation of cholesterol homeostasis (GO:2000188)3.36615111
95striated muscle hypertrophy (GO:0014897)3.35620934
96urate metabolic process (GO:0046415)3.34222212
97carnitine metabolic process (GO:0009437)3.34127836
98monocarboxylic acid catabolic process (GO:0072329)3.33574137
99exogenous drug catabolic process (GO:0042738)3.33466266
100COPII vesicle coating (GO:0048208)3.33301317
101plasma lipoprotein particle remodeling (GO:0034369)3.31081674
102protein-lipid complex remodeling (GO:0034368)3.31081674
103macromolecular complex remodeling (GO:0034367)3.31081674
104muscle atrophy (GO:0014889)3.30340205
105positive regulation of lipid catabolic process (GO:0050996)3.28463864
106uronic acid metabolic process (GO:0006063)3.26741598
107glucuronate metabolic process (GO:0019585)3.26741598
108actomyosin structure organization (GO:0031032)3.25429672
109polysaccharide catabolic process (GO:0000272)3.24917623
110plasma lipoprotein particle assembly (GO:0034377)3.24779214
111organic acid catabolic process (GO:0016054)3.18057874
112carboxylic acid catabolic process (GO:0046395)3.18057874
113negative regulation of cholesterol transport (GO:0032375)3.17813434
114negative regulation of sterol transport (GO:0032372)3.17813434
115regulation of cholesterol esterification (GO:0010872)3.17167701
116protein-lipid complex assembly (GO:0065005)3.15788351
117bile acid and bile salt transport (GO:0015721)3.14722599
118regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.11278386
119amino-acid betaine transport (GO:0015838)3.11151634
120carnitine transport (GO:0015879)3.11151634
121positive regulation of fatty acid oxidation (GO:0046321)3.10925591
122sterol homeostasis (GO:0055092)3.10682758
123cholesterol homeostasis (GO:0042632)3.10673140
124regulation of fatty acid beta-oxidation (GO:0031998)3.10534559
125benzene-containing compound metabolic process (GO:0042537)3.08415715
126low-density lipoprotein particle clearance (GO:0034383)3.07261942
127lipoprotein metabolic process (GO:0042157)3.07209127
128cardiac muscle contraction (GO:0060048)3.07117120
129serine family amino acid metabolic process (GO:0009069)3.06854330
130coenzyme catabolic process (GO:0009109)3.06832427
131regulation of bile acid biosynthetic process (GO:0070857)3.04959806
132indolalkylamine metabolic process (GO:0006586)3.03353893
133cardiac myofibril assembly (GO:0055003)3.02900809
134muscle contraction (GO:0006936)2.96445898
135negative regulation of potassium ion transmembrane transport (GO:1901380)2.96270781
136regulation of actin filament-based movement (GO:1903115)2.94337523
137carnitine transmembrane transport (GO:1902603)2.94025164
138intestinal epithelial cell development (GO:0060576)2.91762695
139muscle hypertrophy (GO:0014896)2.90687165
140negative regulation of protein activation cascade (GO:2000258)2.87041933
141cardiac muscle hypertrophy in response to stress (GO:0014898)2.86622868
142muscle hypertrophy in response to stress (GO:0003299)2.86622868
143cardiac muscle adaptation (GO:0014887)2.86622868
144blood coagulation, intrinsic pathway (GO:0007597)2.85590219
145regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.85254118
146fructose metabolic process (GO:0006000)2.84943124
147glycogen biosynthetic process (GO:0005978)2.80828574
148glucan biosynthetic process (GO:0009250)2.80828574
149macroautophagy (GO:0016236)2.80453433
150intracellular lipid transport (GO:0032365)2.79671785
151peptidyl-lysine dimethylation (GO:0018027)2.74600172
152glycogen metabolic process (GO:0005977)2.74391049
153epoxygenase P450 pathway (GO:0019373)2.71331223
154cellular carbohydrate catabolic process (GO:0044275)2.70673085
155very-low-density lipoprotein particle assembly (GO:0034379)2.68660568
156glucan metabolic process (GO:0044042)2.68567443
157cellular glucan metabolic process (GO:0006073)2.68567443
158muscle adaptation (GO:0043500)2.66339128
159muscle system process (GO:0003012)2.66226283
160growth hormone receptor signaling pathway (GO:0060396)2.64133135
161biotin metabolic process (GO:0006768)2.63737476
162desmosome organization (GO:0002934)2.63470294
163insulin-like growth factor receptor signaling pathway (GO:0048009)2.60919682
164regulation of establishment of cell polarity (GO:2000114)2.59922850
165positive regulation of hormone metabolic process (GO:0032352)2.55857498
166regulation of cell communication by electrical coupling (GO:0010649)2.53272638
167negative regulation of complement activation (GO:0045916)2.52845811
168embryonic retina morphogenesis in camera-type eye (GO:0060059)2.51810438
169cardiac muscle tissue morphogenesis (GO:0055008)2.51686891
170regulation of establishment or maintenance of cell polarity (GO:0032878)2.50011113
171quaternary ammonium group transport (GO:0015697)2.49651086
172tricarboxylic acid cycle (GO:0006099)2.49339595
173positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.48115975
174hepatocyte apoptotic process (GO:0097284)2.47959535
175response to inactivity (GO:0014854)2.47435389
176regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.45274810
177cell-substrate adherens junction assembly (GO:0007045)2.45241435
178focal adhesion assembly (GO:0048041)2.45241435

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.90705258
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.78003337
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.04176941
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.98763498
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.37320581
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.00411704
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.55621286
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.39110107
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.53387492
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.42408938
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.39449224
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.37599436
13CLOCK_20551151_ChIP-Seq_293T_Human2.20600331
14FOXA2_19822575_ChIP-Seq_HepG2_Human1.88058672
15BP1_19119308_ChIP-ChIP_Hs578T_Human1.79873892
16GATA1_22025678_ChIP-Seq_K562_Human1.78938571
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.78522716
18ESR1_21235772_ChIP-Seq_MCF-7_Human1.75235300
19TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.73833427
20* GATA3_24758297_ChIP-Seq_MCF-7_Human1.71979100
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70692833
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.70314571
23PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.69000216
24* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63450222
25TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.60630921
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.59008084
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58947474
28ER_23166858_ChIP-Seq_MCF-7_Human1.53984237
29FOXO3_23340844_ChIP-Seq_DLD1_Human1.52849921
30BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.52757415
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.52630736
32NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.46440218
33NRF2_20460467_ChIP-Seq_MEFs_Mouse1.46440218
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.45970853
35* ESR1_20079471_ChIP-ChIP_T-47D_Human1.45683021
36PPAR_26484153_Chip-Seq_NCI-H1993_Human1.40833040
37HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.40604981
38SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40341306
39SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.38068844
40SALL4_18804426_ChIP-ChIP_XEN_Mouse1.37245684
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35171197
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34997047
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.33216201
44ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30643073
45CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30566510
46RUNX1_27514584_Chip-Seq_MCF-7_Human1.29755283
47CTNNB1_20460455_ChIP-Seq_HCT116_Human1.28266400
48HNF4A_19822575_ChIP-Seq_HepG2_Human1.26437638
49IRF8_27001747_Chip-Seq_BMDM_Mouse1.25215987
50* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.21996736
51GATA4_21415370_ChIP-Seq_HL-1_Mouse1.21410215
52NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19544544
53* GATA2_21666600_ChIP-Seq_HMVEC_Human1.19345875
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.19292561
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17362844
56TCF4_18268006_ChIP-ChIP_LS174T_Human1.17165691
57TBX20_22080862_ChIP-Seq_HEART_Mouse1.16166764
58TBX20_22328084_ChIP-Seq_HEART_Mouse1.16166764
59IRF8_22096565_ChIP-ChIP_GC-B_Human1.15782931
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15545215
61TRIM28_21343339_ChIP-Seq_HEK293_Human1.12682280
62ZNF263_19887448_ChIP-Seq_K562_Human1.12216574
63* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.11353702
64* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10307444
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09844093
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09442695
67AR_21909140_ChIP-Seq_LNCAP_Human1.08831645
68EP300_21415370_ChIP-Seq_HL-1_Mouse1.07872251
69* GATA4_25053715_ChIP-Seq_YYC3_Human1.07420769
70WT1_19549856_ChIP-ChIP_CCG9911_Human1.06643991
71SMAD3_21741376_ChIP-Seq_HESCs_Human1.06239151
72* CJUN_26792858_Chip-Seq_BT549_Human1.05185462
73* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05007846
74NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.04614975
75FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02137991
76SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01831074
77TP63_17297297_ChIP-ChIP_HaCaT_Human1.01141083
78TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00818111
79KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00206880
80VDR_24787735_ChIP-Seq_THP-1_Human0.98425294
81POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98261498
82CHD1_26751641_Chip-Seq_LNCaP_Human0.95790318
83STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.95635510
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95074576
85MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94193243
86TAF15_26573619_Chip-Seq_HEK293_Human0.94142174
87IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93513326
88* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93374931
89SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93249837
90EZH2_27294783_Chip-Seq_NPCs_Mouse0.93159159
91AHR_22903824_ChIP-Seq_MCF-7_Human0.92877705
92CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92294580
93PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91262909
94EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.90261206
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90172615
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89971295
97BCAT_22108803_ChIP-Seq_LS180_Human0.89638918
98FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89225648
99ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88330061
100GATA1_19941826_ChIP-Seq_K562_Human0.87616626
101TP63_23658742_ChIP-Seq_EP156T_Human0.84971852
102CDX2_20551321_ChIP-Seq_CACO-2_Human0.84733146
103* SOX2_20726797_ChIP-Seq_SW620_Human0.84214087
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84141075
105* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83687915
106FOXM1_26456572_ChIP-Seq_MCF-7_Human0.83432165
107TP53_16413492_ChIP-PET_HCT116_Human0.83207338
108PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.82614730
109* GATA6_25053715_ChIP-Seq_YYC3_Human0.82369438
110SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.82216333
111GATA2_19941826_ChIP-Seq_K562_Human0.80623176
112RXR_22108803_ChIP-Seq_LS180_Human0.78350744
113ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.77785104
114ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.77667946
115SALL1_21062744_ChIP-ChIP_HESCs_Human0.76616312
116* ARNT_22903824_ChIP-Seq_MCF-7_Human0.76126432
117BRD4_27068464_Chip-Seq_AML-cells_Mouse0.75317237
118CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.75261936
119PIAS1_25552417_ChIP-Seq_VCAP_Human0.75082525
120PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75047967
121FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.74992519
122* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.74594215
123PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.74576306
124CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.73405661
125* CDX2_22108803_ChIP-Seq_LS180_Human0.72974133
126* FOXA1_25552417_ChIP-Seq_VCAP_Human0.72031884
127PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.72005272
128P300_27058665_Chip-Seq_ZR-75-30cells_Human0.71957506
129SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.71904459
130SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.71904459
131TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.71199707
132HTT_18923047_ChIP-ChIP_STHdh_Human0.70526121
133SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68544233

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.42442040
2MP0005360_urolithiasis6.19258780
3MP0005085_abnormal_gallbladder_physiolo4.73038848
4MP0005365_abnormal_bile_salt4.56229989
5MP0008875_abnormal_xenobiotic_pharmacok3.79792502
6MP0003252_abnormal_bile_duct3.33306575
7MP0005083_abnormal_biliary_tract2.93620343
8MP0010329_abnormal_lipoprotein_level2.90732921
9MP0003806_abnormal_nucleotide_metabolis2.86821973
10MP0009840_abnormal_foam_cell2.86004613
11MP0003191_abnormal_cellular_cholesterol2.72511961
12MP0005332_abnormal_amino_acid2.47065676
13MP0009780_abnormal_chondrocyte_physiolo2.44597225
14MP0003705_abnormal_hypodermis_morpholog2.40988055
15MP0004130_abnormal_muscle_cell2.39663905
16MP0000569_abnormal_digit_pigmentation2.32782808
17MP0005058_abnormal_lysosome_morphology2.18093476
18MP0004484_altered_response_of2.17600200
19MP0002138_abnormal_hepatobiliary_system2.14004236
20MP0006138_congestive_heart_failure2.05887178
21MP0003195_calcinosis2.04938942
22MP0004264_abnormal_extraembryonic_tissu2.03835126
23MP0004019_abnormal_vitamin_homeostasis2.03106792
24MP0001666_abnormal_nutrient_absorption1.99485802
25MP0004215_abnormal_myocardial_fiber1.95016748
26MP0003828_pulmonary_edema1.94458910
27MP0002118_abnormal_lipid_homeostasis1.89732216
28MP0002009_preneoplasia1.86805173
29MP0000609_abnormal_liver_physiology1.86280524
30MP0003941_abnormal_skin_development1.85167039
31MP0002972_abnormal_cardiac_muscle1.82416471
32MP0003221_abnormal_cardiomyocyte_apopto1.70047925
33MP0008438_abnormal_cutaneous_collagen1.68429891
34MP0002127_abnormal_cardiovascular_syste1.56121933
35MP0005319_abnormal_enzyme/_coenzyme1.53727429
36MP0003690_abnormal_glial_cell1.50499260
37MP0005670_abnormal_white_adipose1.46756599
38MP0002796_impaired_skin_barrier1.44699268
39MP0002254_reproductive_system_inflammat1.43700240
40MP0005584_abnormal_enzyme/coenzyme_acti1.42533836
41MP0005666_abnormal_adipose_tissue1.41635162
42MP0009643_abnormal_urine_homeostasis1.39163272
43MP0003300_gastrointestinal_ulcer1.36222354
44MP0000604_amyloidosis1.35010230
45MP0003890_abnormal_embryonic-extraembry1.32312501
46MP0004185_abnormal_adipocyte_glucose1.32254279
47MP0000747_muscle_weakness1.29091753
48MP0000749_muscle_degeneration1.26340023
49MP0010678_abnormal_skin_adnexa1.24040891
50MP0000750_abnormal_muscle_regeneration1.22318577
51MP0000383_abnormal_hair_follicle1.20880694
52MP0000751_myopathy1.20407646
53MP0002971_abnormal_brown_adipose1.13657596
54MP0005275_abnormal_skin_tensile1.13531940
55MP0004510_myositis1.12665736
56MP0003656_abnormal_erythrocyte_physiolo1.11572835
57MP0001958_emphysema1.10332676
58MP0002269_muscular_atrophy1.09398828
59MP0003646_muscle_fatigue1.07694366
60MP0008057_abnormal_DNA_replication1.06772477
61MP0004087_abnormal_muscle_fiber1.04165633
62MP0003186_abnormal_redox_activity1.03527775
63MP0002166_altered_tumor_susceptibility1.03395222
64MP0008260_abnormal_autophagy1.02848707
65MP0002837_dystrophic_cardiac_calcinosis1.01436888
66MP0010368_abnormal_lymphatic_system0.99579107
67MP0004145_abnormal_muscle_electrophysio0.99453674
68MP0003868_abnormal_feces_composition0.99327839
69MP0004036_abnormal_muscle_relaxation0.98932919
70MP0000598_abnormal_liver_morphology0.98695146
71MP0002877_abnormal_melanocyte_morpholog0.96955482
72MP0005076_abnormal_cell_differentiation0.96844901
73MP0001756_abnormal_urination0.93209157
74MP0009764_decreased_sensitivity_to0.92505360
75MP0003183_abnormal_peptide_metabolism0.92103188
76MP0003453_abnormal_keratinocyte_physiol0.91965636
77MP0003172_abnormal_lysosome_physiology0.89072986
78MP0005409_darkened_coat_color0.87038733
79MP0008775_abnormal_heart_ventricle0.86966841
80MP0009763_increased_sensitivity_to0.86709441
81MP0000266_abnormal_heart_morphology0.86116910
82MP0003011_delayed_dark_adaptation0.84791749
83MP0005334_abnormal_fat_pad0.84535403
84MP0005647_abnormal_sex_gland0.83439149
85MP0004381_abnormal_hair_follicle0.83247699
86MP0006054_spinal_hemorrhage0.82745322
87MP0002128_abnormal_blood_circulation0.81851767
88MP0002136_abnormal_kidney_physiology0.81003357
89MP0001727_abnormal_embryo_implantation0.80923478
90MP0002332_abnormal_exercise_endurance0.80186451
91MP0009672_abnormal_birth_weight0.79281546
92MP0002088_abnormal_embryonic_growth/wei0.78968179
93MP0008004_abnormal_stomach_pH0.78879614
94MP0003566_abnormal_cell_adhesion0.78747001
95MP0002168_other_aberrant_phenotype0.78290521
96MP0005375_adipose_tissue_phenotype0.78117084
97MP0000627_abnormal_mammary_gland0.77579203
98MP0004043_abnormal_pH_regulation0.76699267
99MP0001764_abnormal_homeostasis0.76524293
100MP0005451_abnormal_body_composition0.75774562
101MP0003984_embryonic_growth_retardation0.75237365
102MP0005620_abnormal_muscle_contractility0.74862181
103MP0004085_abnormal_heartbeat0.74616643
104MP0008469_abnormal_protein_level0.74393304
105MP0010234_abnormal_vibrissa_follicle0.73832313
106MP0005636_abnormal_mineral_homeostasis0.73820683
107MP0005330_cardiomyopathy0.73357516
108MP0006036_abnormal_mitochondrial_physio0.72149793
109MP0009697_abnormal_copulation0.71746120
110MP0000003_abnormal_adipose_tissue0.70913858
111MP0005408_hypopigmentation0.70701277
112MP0002896_abnormal_bone_mineralization0.70169746
113MP0003950_abnormal_plasma_membrane0.69740961
114MP0004272_abnormal_basement_membrane0.69530137
115MP0000427_abnormal_hair_cycle0.68940848
116MP0001915_intracranial_hemorrhage0.68525567
117MP0002106_abnormal_muscle_physiology0.68036194
118MP0000013_abnormal_adipose_tissue0.67688400
119MP0002078_abnormal_glucose_homeostasis0.67055667
120MP0009115_abnormal_fat_cell0.67032783
121MP0009642_abnormal_blood_homeostasis0.65771913
122MP0000759_abnormal_skeletal_muscle0.65531453
123MP0001661_extended_life_span0.65202848
124MP0010630_abnormal_cardiac_muscle0.65112413
125MP0002060_abnormal_skin_morphology0.61258535
126MP0005167_abnormal_blood-brain_barrier0.60750969
127MP0005166_decreased_susceptibility_to0.57135430
128MP0005369_muscle_phenotype0.56071532
129MP0000733_abnormal_muscle_development0.55009291
130MP0004782_abnormal_surfactant_physiolog0.54980779
131MP0002108_abnormal_muscle_morphology0.52538238
132MP0003045_fibrosis0.52307727
133MP0000371_diluted_coat_color0.52109169
134MP0009384_cardiac_valve_regurgitation0.52013679
135MP0005376_homeostasis/metabolism_phenot0.51723190
136MP0001544_abnormal_cardiovascular_syste0.51166759
137MP0005385_cardiovascular_system_phenoty0.51166759
138MP0004084_abnormal_cardiac_muscle0.50741941
139MP0006082_CNS_inflammation0.50121544
140MP0004233_abnormal_muscle_weight0.50063559
141MP0005266_abnormal_metabolism0.49803133
142MP0005535_abnormal_body_temperature0.49178371

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.12727904
2Deep venous thrombosis (HP:0002625)5.10252804
3Complement deficiency (HP:0004431)4.88703780
4Xanthomatosis (HP:0000991)4.85435675
5Abnormality of aromatic amino acid family metabolism (HP:0004338)4.29725493
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.21580251
7Hypoalphalipoproteinemia (HP:0003233)4.11937129
8Calf muscle hypertrophy (HP:0008981)3.86360298
9EMG: myopathic abnormalities (HP:0003458)3.86124279
10Bundle branch block (HP:0011710)3.76587641
11Hyperammonemia (HP:0001987)3.74872846
12Hypolipoproteinemia (HP:0010981)3.73380082
13Hyperlipoproteinemia (HP:0010980)3.69460986
14Hypobetalipoproteinemia (HP:0003563)3.69048774
15Abnormality of glutamine family amino acid metabolism (HP:0010902)3.67090433
16Ketosis (HP:0001946)3.66717947
17Abnormality of the left ventricular outflow tract (HP:0011103)3.66421416
18Subaortic stenosis (HP:0001682)3.66421416
19Epidermoid cyst (HP:0200040)3.61008861
20Abnormality of complement system (HP:0005339)3.55938035
21Hyperglycinuria (HP:0003108)3.50782415
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.47673708
23Prolonged partial thromboplastin time (HP:0003645)3.39472974
24Abnormality of serine family amino acid metabolism (HP:0010894)3.38745330
25Abnormality of glycine metabolism (HP:0010895)3.38745330
26Abnormality of the calf musculature (HP:0001430)3.36478552
27Myocardial infarction (HP:0001658)3.36267947
28Neck muscle weakness (HP:0000467)3.33960705
29Sudden death (HP:0001699)3.32124100
30Rimmed vacuoles (HP:0003805)3.31135603
31Hyperglycinemia (HP:0002154)3.30091279
32Exercise-induced muscle cramps (HP:0003710)3.28880529
33Systemic lupus erythematosus (HP:0002725)3.27211830
34Abnormality of sulfur amino acid metabolism (HP:0004339)3.23159088
35Gout (HP:0001997)3.21871617
36Abnormality of aspartate family amino acid metabolism (HP:0010899)3.19317977
37Joint hemorrhage (HP:0005261)3.17520855
38Abnormality of purine metabolism (HP:0004352)3.15117161
39Centrally nucleated skeletal muscle fibers (HP:0003687)3.10508362
40Exercise-induced myalgia (HP:0003738)3.05580510
41Ventricular tachycardia (HP:0004756)3.04685172
42Hypercholesterolemia (HP:0003124)3.04496176
43Hypoglycemic coma (HP:0001325)3.00381198
44Abnormality of fatty-acid metabolism (HP:0004359)2.98311910
45Abnormality of the common coagulation pathway (HP:0010990)2.96760166
46Ketoacidosis (HP:0001993)2.86996590
47Myoglobinuria (HP:0002913)2.84487627
48Fat malabsorption (HP:0002630)2.83097542
49Myopathic facies (HP:0002058)2.82356247
50Hyperkalemia (HP:0002153)2.82005043
51Abnormality of skeletal muscle fiber size (HP:0012084)2.80425405
52Skin nodule (HP:0200036)2.74282487
53Glomerulonephritis (HP:0000099)2.74121305
54Testicular neoplasm (HP:0010788)2.73654490
55Papillary thyroid carcinoma (HP:0002895)2.73392148
56Abnormality of methionine metabolism (HP:0010901)2.72284993
57Abnormality of nucleobase metabolism (HP:0010932)2.71577038
58EMG: neuropathic changes (HP:0003445)2.69984472
59Hyperuricemia (HP:0002149)2.64338307
60Increased purine levels (HP:0004368)2.64338307
61Hyporeflexia of lower limbs (HP:0002600)2.61443286
62Areflexia of lower limbs (HP:0002522)2.55598726
63Hepatocellular carcinoma (HP:0001402)2.54471564
64Muscle fiber inclusion bodies (HP:0100299)2.54430876
65Round ear (HP:0100830)2.49012422
66Frequent falls (HP:0002359)2.48679317
67Axonal loss (HP:0003447)2.47947045
68Esophageal varix (HP:0002040)2.47057058
69Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.39271406
70Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.35979179
71Vascular calcification (HP:0004934)2.35742141
72Dilated cardiomyopathy (HP:0001644)2.35572002
73Increased connective tissue (HP:0009025)2.35229770
74Abnormality of the intrinsic pathway (HP:0010989)2.31865118
75Hydroxyprolinuria (HP:0003080)2.31076756
76Abnormality of proline metabolism (HP:0010907)2.31076756
77Metabolic acidosis (HP:0001942)2.29768128
78Increased variability in muscle fiber diameter (HP:0003557)2.29679019
79Heart block (HP:0012722)2.29657787
80Cardiovascular calcification (HP:0011915)2.26416661
81Rhabdomyolysis (HP:0003201)2.26279366
82Difficulty running (HP:0009046)2.23815888
83Conjugated hyperbilirubinemia (HP:0002908)2.22958401
84Sensorimotor neuropathy (HP:0007141)2.20767450
85Abnormality of serum amino acid levels (HP:0003112)2.20381673
86Dicarboxylic aciduria (HP:0003215)2.18824484
87Abnormality of dicarboxylic acid metabolism (HP:0010995)2.18824484
88Nephritis (HP:0000123)2.17515606
89Bulbar palsy (HP:0001283)2.16744092
90Peripheral demyelination (HP:0011096)2.16264567
91Nemaline bodies (HP:0003798)2.13673935
92Termporal pattern (HP:0011008)2.13185901
93Insidious onset (HP:0003587)2.13185901
94Proximal tubulopathy (HP:0000114)2.12932895
95Asymmetric septal hypertrophy (HP:0001670)2.12811398
96Abnormal atrioventricular conduction (HP:0005150)2.12319699
97Type 1 muscle fiber predominance (HP:0003803)2.10952828
98Steatorrhea (HP:0002570)2.10447503
99Increased CSF protein (HP:0002922)2.09030256
100Tetraparesis (HP:0002273)2.07379155
101Atrioventricular block (HP:0001678)2.07112871
102Lipoatrophy (HP:0100578)2.06610314
103Muscle fiber splitting (HP:0003555)2.06456739
104Spastic diplegia (HP:0001264)2.03738162
105Germ cell neoplasia (HP:0100728)2.03312993
106Cholelithiasis (HP:0001081)2.03029668
107Delayed CNS myelination (HP:0002188)2.01938637
108Hypochromic microcytic anemia (HP:0004840)2.01693101
109Gonadal dysgenesis (HP:0000133)2.01417260
110Recurrent gram-negative bacterial infections (HP:0005420)2.00551171
111Mildly elevated creatine phosphokinase (HP:0008180)1.99488584
112Hyperbilirubinemia (HP:0002904)1.99101560
113Amyloidosis (HP:0011034)1.93690320
114Flat acetabular roof (HP:0003180)1.92979607
115Abnormal gallbladder morphology (HP:0012437)1.92741229
116Abnormality of the Achilles tendon (HP:0005109)1.91838510
117Scapular winging (HP:0003691)1.91446694
118Ventricular arrhythmia (HP:0004308)1.90061824
119Absent phalangeal crease (HP:0006109)1.89918267
120Protuberant abdomen (HP:0001538)1.89883613
121Microglossia (HP:0000171)1.86934630
122Distal lower limb muscle weakness (HP:0009053)1.86915297
123Upper motor neuron abnormality (HP:0002127)1.85991188
124Generalized aminoaciduria (HP:0002909)1.84735860
125Abnormality of pyrimidine metabolism (HP:0004353)1.84496792
126Right ventricular cardiomyopathy (HP:0011663)1.84345589
127Malignant hyperthermia (HP:0002047)1.83284406
128Arterial tortuosity (HP:0005116)1.83088835
129Muscle stiffness (HP:0003552)1.82808666
130Vacuolated lymphocytes (HP:0001922)1.82021594
131Mitral stenosis (HP:0001718)1.80967381
132Malnutrition (HP:0004395)1.80701668
133Abnormality of iron homeostasis (HP:0011031)1.79811684
134Distal arthrogryposis (HP:0005684)1.78076045
135Spontaneous abortion (HP:0005268)1.77857829
136Muscle hypertrophy of the lower extremities (HP:0008968)1.77158424
137Hemorrhage of the eye (HP:0011885)1.76439468
138Ulnar deviation of the wrist (HP:0003049)1.75627005
139Global brain atrophy (HP:0002283)1.72821791
140Abnormal finger flexion creases (HP:0006143)1.72652033
141Vomiting (HP:0002013)1.72650973
142Curly hair (HP:0002212)1.70038847
143Menorrhagia (HP:0000132)1.68817079
144Gowers sign (HP:0003391)1.66116652
145Back pain (HP:0003418)1.65605911
146Palpitations (HP:0001962)1.65167042
147Distal lower limb amyotrophy (HP:0008944)1.64794928
148Hyperphosphatemia (HP:0002905)1.62665342
149Progressive external ophthalmoplegia (HP:0000590)1.60665934
150Skin pits (HP:0100276)1.59268772
151Progressive muscle weakness (HP:0003323)1.58818576
152Abnormal tarsal ossification (HP:0008369)1.58730415
153Biliary tract neoplasm (HP:0100574)1.58467307
154Thyroid carcinoma (HP:0002890)1.58425543
155Hypoplastic left heart (HP:0004383)1.57646785
156Dysmetric saccades (HP:0000641)1.57166016
157Sparse lateral eyebrow (HP:0005338)1.56521586
158Generalized muscle weakness (HP:0003324)1.54615346
159Osteomalacia (HP:0002749)1.53208839
160Gonadotropin excess (HP:0000837)1.53017071

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN3.53489178
2BCKDK3.42179343
3OBSCN2.76087514
4CAMK1D2.72358430
5LATS12.56984033
6TRIB32.49729891
7SIK12.33579997
8NEK92.25014347
9MAPKAPK32.17766757
10FRK2.17026025
11MAP3K122.14073176
12CAMK1G2.06001652
13PKN21.97301359
14ERN11.93893403
15MAP2K31.85831054
16RIPK11.83264074
17SIK31.79782267
18PHKG11.79618109
19PHKG21.79618109
20STK241.76309781
21PIK3CG1.76063092
22PTK61.73479058
23FGFR41.71248346
24TGFBR21.70151957
25MST41.69348920
26EEF2K1.61743435
27AKT31.58454712
28MAP3K31.55801354
29TYK21.54427417
30TAOK31.49526546
31MAP3K71.48607840
32LMTK21.44201555
33MAP2K41.43662514
34CDK61.43474294
35INSRR1.39677776
36NLK1.39518439
37NEK61.39108509
38PIK3CA1.37536183
39PDK41.37396618
40PDK31.37396618
41ERBB31.35557658
42EPHB11.34196329
43MYLK1.29986370
44TRIM281.29211096
45EIF2AK31.28757365
46EPHA21.26954163
47PRKAA21.24139808
48WNK41.23103777
49ERBB41.20441708
50JAK11.16038854
51SGK31.14682157
52ACVR1B1.14569934
53FGFR21.11275717
54STK391.06730958
55MST1R1.06509219
56MAP3K21.06426842
57DAPK21.01377142
58SCYL20.99978392
59NEK10.99971252
60MAPK120.98543663
61MUSK0.97214439
62STK380.96515993
63JAK20.96217447
64RPS6KB20.96044584
65WNK10.92960232
66CDK120.92597099
67STK30.92210966
68PDK20.90055983
69MET0.90032475
70MAPK110.88540095
71YES10.86587039
72FGFR30.85241428
73PRKAA10.82552390
74BRSK20.82549787
75DMPK0.82531110
76SGK20.79485594
77OXSR10.79250150
78RPS6KB10.78680055
79PDGFRA0.77077251
80GSK3A0.76958163
81STK38L0.75946573
82ERBB20.73181501
83PDPK10.72294150
84MAP3K10.71466636
85PINK10.70219982
86SGK2230.68105366
87SGK4940.68105366
88PDGFRB0.66969928
89RET0.66732296
90KSR10.65982033
91ICK0.64980556
92MTOR0.64729656
93MAP3K140.63873799
94MAP2K10.63161912
95MELK0.63077728
96MAP3K130.63053262
97EGFR0.62156636
98PNCK0.61833474
99MAPK70.59435512
100TBK10.58208826
101EIF2AK10.57985088
102TRPM70.56974821
103PTK20.56102236
104SGK10.55742413
105PDK10.55640754
106PRKD10.53458237
107PKN10.52905214
108MAP3K90.51735379
109CSK0.51336888
110ABL20.49072468
111MAP3K60.48610306
112LRRK20.48352596
113CHUK0.48138704
114CAMKK10.47753641
115BMPR20.47131825
116CAMK2D0.44619756
117PRKACG0.44606219
118CAMK40.44188602
119NUAK10.43897856
120CSF1R0.43085078
121ROCK10.43073818
122KIT0.40690669
123FLT30.40226062
124IGF1R0.39885713
125MAP3K50.39131543
126MAP3K100.38394487
127LATS20.38021430
128FER0.37495809
129TAOK10.37437301
130PRKCQ0.36957196
131TIE10.36862073
132STK100.36736691
133BRD40.36714083
134AKT20.36473378
135FGFR10.35649120
136DYRK1B0.35379038
137CAMK2G0.35140307
138PRKCH0.35086388
139MAPK100.34592954

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.88451943
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.60831010
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.18988036
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.00650586
5Fatty acid degradation_Homo sapiens_hsa000712.76641646
6Arginine biosynthesis_Homo sapiens_hsa002202.67715864
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.62130415
8Propanoate metabolism_Homo sapiens_hsa006402.45973805
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.44462415
10Complement and coagulation cascades_Homo sapiens_hsa046102.40868325
11Tryptophan metabolism_Homo sapiens_hsa003802.36302860
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.29749943
13Butanoate metabolism_Homo sapiens_hsa006502.24739251
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22931212
15PPAR signaling pathway_Homo sapiens_hsa033202.10760576
16Fatty acid metabolism_Homo sapiens_hsa012122.08488046
17Circadian rhythm_Homo sapiens_hsa047102.01382248
18Staphylococcus aureus infection_Homo sapiens_hsa051501.96242848
19Peroxisome_Homo sapiens_hsa041461.93102892
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.90970503
21Caffeine metabolism_Homo sapiens_hsa002321.89038288
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.85737327
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74697363
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.72427518
25beta-Alanine metabolism_Homo sapiens_hsa004101.66769399
26Bile secretion_Homo sapiens_hsa049761.59413660
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.58528448
28Starch and sucrose metabolism_Homo sapiens_hsa005001.54353834
29Chemical carcinogenesis_Homo sapiens_hsa052041.49603588
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.48271298
31Thyroid cancer_Homo sapiens_hsa052161.45618579
32Histidine metabolism_Homo sapiens_hsa003401.43958743
33Pyruvate metabolism_Homo sapiens_hsa006201.43900766
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.37372295
35Endometrial cancer_Homo sapiens_hsa052131.33478090
36Carbon metabolism_Homo sapiens_hsa012001.29944834
37Selenocompound metabolism_Homo sapiens_hsa004501.28831721
38Retinol metabolism_Homo sapiens_hsa008301.28133417
39ABC transporters_Homo sapiens_hsa020101.27390893
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26918215
41Lysine degradation_Homo sapiens_hsa003101.19681670
42Renal cell carcinoma_Homo sapiens_hsa052111.18720314
43Sulfur metabolism_Homo sapiens_hsa009201.18296430
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.16659073
45Phenylalanine metabolism_Homo sapiens_hsa003601.16291897
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14935646
47Tight junction_Homo sapiens_hsa045301.07894943
48Drug metabolism - other enzymes_Homo sapiens_hsa009831.03892342
49Fatty acid elongation_Homo sapiens_hsa000621.02204885
50Non-small cell lung cancer_Homo sapiens_hsa052231.00967387
51Fat digestion and absorption_Homo sapiens_hsa049750.97424395
52Tyrosine metabolism_Homo sapiens_hsa003500.95151174
53Biosynthesis of amino acids_Homo sapiens_hsa012300.93222665
54FoxO signaling pathway_Homo sapiens_hsa040680.92405763
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89858152
56Glycerolipid metabolism_Homo sapiens_hsa005610.89101371
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85123823
58Steroid biosynthesis_Homo sapiens_hsa001000.84914407
59Fatty acid biosynthesis_Homo sapiens_hsa000610.84558336
60Arginine and proline metabolism_Homo sapiens_hsa003300.84212587
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.83984312
62Prostate cancer_Homo sapiens_hsa052150.82206400
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81804278
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81456793
65Inositol phosphate metabolism_Homo sapiens_hsa005620.79789387
66Platelet activation_Homo sapiens_hsa046110.77115864
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.76250138
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75940091
69mTOR signaling pathway_Homo sapiens_hsa041500.75311179
70Insulin resistance_Homo sapiens_hsa049310.69361503
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69141852
72Pancreatic cancer_Homo sapiens_hsa052120.67645820
73Vitamin digestion and absorption_Homo sapiens_hsa049770.66390886
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.62656408
75Choline metabolism in cancer_Homo sapiens_hsa052310.62424622
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.61057406
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.59848418
78ErbB signaling pathway_Homo sapiens_hsa040120.59079177
79Prolactin signaling pathway_Homo sapiens_hsa049170.57161848
80Lysosome_Homo sapiens_hsa041420.56892997
81Acute myeloid leukemia_Homo sapiens_hsa052210.56498546
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55566475
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.53723643
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.53421274
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53250677
86HIF-1 signaling pathway_Homo sapiens_hsa040660.52528759
87T cell receptor signaling pathway_Homo sapiens_hsa046600.51831422
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51688633
89Renin secretion_Homo sapiens_hsa049240.51456183
90Glutathione metabolism_Homo sapiens_hsa004800.51403512
91Chronic myeloid leukemia_Homo sapiens_hsa052200.51305381
92TGF-beta signaling pathway_Homo sapiens_hsa043500.50582332
93Vitamin B6 metabolism_Homo sapiens_hsa007500.50513993
94GnRH signaling pathway_Homo sapiens_hsa049120.46253427
95Estrogen signaling pathway_Homo sapiens_hsa049150.45752626
96VEGF signaling pathway_Homo sapiens_hsa043700.45679170
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44919983
98AMPK signaling pathway_Homo sapiens_hsa041520.44756299
99Glioma_Homo sapiens_hsa052140.44439418
100Pentose phosphate pathway_Homo sapiens_hsa000300.41015098
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40883956
102Long-term potentiation_Homo sapiens_hsa047200.38430782
103Folate biosynthesis_Homo sapiens_hsa007900.37887839
104Oxytocin signaling pathway_Homo sapiens_hsa049210.37546437
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37251306
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37039750
107Glucagon signaling pathway_Homo sapiens_hsa049220.33104188
108Insulin signaling pathway_Homo sapiens_hsa049100.31000976
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30129386
110Mineral absorption_Homo sapiens_hsa049780.27428548
111Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26963510
112Galactose metabolism_Homo sapiens_hsa000520.24513190
113Amoebiasis_Homo sapiens_hsa051460.24393128
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.23820972
115Dilated cardiomyopathy_Homo sapiens_hsa054140.22690519
116ECM-receptor interaction_Homo sapiens_hsa045120.21180653
117Metabolic pathways_Homo sapiens_hsa011000.20802885
118Renin-angiotensin system_Homo sapiens_hsa046140.19584721
119Prion diseases_Homo sapiens_hsa050200.19127851
120One carbon pool by folate_Homo sapiens_hsa006700.17348033
121Fructose and mannose metabolism_Homo sapiens_hsa000510.17266582
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.16520277
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.15924168
124Focal adhesion_Homo sapiens_hsa045100.15007711
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.14793647
126Sulfur relay system_Homo sapiens_hsa041220.14398614
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.12501828
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.11932012
129Protein digestion and absorption_Homo sapiens_hsa049740.10195552
130Type II diabetes mellitus_Homo sapiens_hsa049300.10068227
131alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.09492453
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.09126104
133Adherens junction_Homo sapiens_hsa045200.07782879
134Proteoglycans in cancer_Homo sapiens_hsa052050.07183632
135Other glycan degradation_Homo sapiens_hsa005110.05910549
136Hepatitis C_Homo sapiens_hsa051600.05378356
137Dorso-ventral axis formation_Homo sapiens_hsa043200.04666434

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