WWP1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of actin monomers (GO:0042989)9.52836251
2histone H4-K12 acetylation (GO:0043983)7.65284140
3negative regulation of execution phase of apoptosis (GO:1900118)5.83317051
4positive regulation of action potential (GO:0045760)5.80683508
5lens morphogenesis in camera-type eye (GO:0002089)5.51380299
6cell junction maintenance (GO:0034331)5.44934966
7regulation of cell communication by electrical coupling (GO:0010649)5.24949778
8cell-cell junction maintenance (GO:0045217)5.09747473
9dopamine biosynthetic process (GO:0042416)4.92619889
10response to insecticide (GO:0017085)4.90950584
11alternative mRNA splicing, via spliceosome (GO:0000380)4.74348089
12dopaminergic neuron differentiation (GO:0071542)4.65872174
13regulation of action potential (GO:0098900)4.63475044
14regulation of acrosome reaction (GO:0060046)4.42916663
15fusion of sperm to egg plasma membrane (GO:0007342)4.42686497
16rRNA methylation (GO:0031167)4.41739848
17neuronal action potential (GO:0019228)4.36510078
18regulation of energy homeostasis (GO:2000505)4.25933298
19apical protein localization (GO:0045176)4.08523363
20negative regulation of activin receptor signaling pathway (GO:0032926)4.01978111
21positive regulation of sodium ion transmembrane transporter activity (GO:2000651)4.00500595
22neural tube formation (GO:0001841)3.95667264
23DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.85560912
24sperm capacitation (GO:0048240)3.83724838
25regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.79490631
26catechol-containing compound biosynthetic process (GO:0009713)3.74421922
27catecholamine biosynthetic process (GO:0042423)3.74421922
28ear development (GO:0043583)3.72693629
29negative regulation of gene silencing (GO:0060969)3.65330652
30embryonic body morphogenesis (GO:0010172)3.64855850
31spinal cord motor neuron differentiation (GO:0021522)3.58370589
32protein polyglutamylation (GO:0018095)3.56178808
33cellular response to nicotine (GO:0071316)3.55905382
34pyrimidine nucleobase catabolic process (GO:0006208)3.54861765
35negative regulation of meiosis (GO:0045835)3.51184703
36positive regulation of oligodendrocyte differentiation (GO:0048714)3.49617069
37DNA damage response, signal transduction resulting in transcription (GO:0042772)3.43337968
38regulation of hexokinase activity (GO:1903299)3.41256114
39regulation of glucokinase activity (GO:0033131)3.41256114
40rRNA modification (GO:0000154)3.38904112
41epithelial cell differentiation involved in kidney development (GO:0035850)3.36903501
42embryonic epithelial tube formation (GO:0001838)3.35528750
43sequestering of extracellular ligand from receptor (GO:0035581)3.32402857
44plasma membrane fusion (GO:0045026)3.30056374
45positive regulation of protein targeting to membrane (GO:0090314)3.25395662
46hindbrain development (GO:0030902)3.22632967
47epithelial tube formation (GO:0072175)3.21542922
48regulation of execution phase of apoptosis (GO:1900117)3.21063329
49negative regulation of meiotic cell cycle (GO:0051447)3.20478250
50serotonin metabolic process (GO:0042428)3.19040497
51DNA deamination (GO:0045006)3.18607569
52positive regulation of sodium ion transmembrane transport (GO:1902307)3.16366359
53negative regulation of telomere maintenance (GO:0032205)3.15690266
54action potential (GO:0001508)3.07983493
55metanephric mesenchyme development (GO:0072075)3.07939118
56positive regulation of fatty acid beta-oxidation (GO:0032000)3.06953734
57cytidine metabolic process (GO:0046087)3.04011022
58cytidine catabolic process (GO:0006216)3.04011022
59cytidine deamination (GO:0009972)3.04011022
60glomerulus development (GO:0032835)3.00837073
61G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.99351972
62camera-type eye morphogenesis (GO:0048593)2.98100517
63neuron maturation (GO:0042551)2.97733460
64body morphogenesis (GO:0010171)2.96717668
65maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.95854024
66thrombin receptor signaling pathway (GO:0070493)2.92441022
67regulation of gene silencing by RNA (GO:0060966)2.92366676
68regulation of posttranscriptional gene silencing (GO:0060147)2.92366676
69regulation of gene silencing by miRNA (GO:0060964)2.92366676
70negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.91257180
71negative regulation of catenin import into nucleus (GO:0035414)2.90001843
72epithelial cilium movement (GO:0003351)2.89860439
73piRNA metabolic process (GO:0034587)2.87378041
74postsynaptic membrane organization (GO:0001941)2.86564106
75midbrain development (GO:0030901)2.84949704
76oligosaccharide biosynthetic process (GO:0009312)2.84496309
77T-helper cell differentiation (GO:0042093)2.83247833
78CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.83247833
79drug catabolic process (GO:0042737)2.82871172
80lymphoid progenitor cell differentiation (GO:0002320)2.81259102
81microtubule severing (GO:0051013)2.81167503
82galactose catabolic process (GO:0019388)2.80386715
83peptidyl-histidine modification (GO:0018202)2.79454321
84primary amino compound metabolic process (GO:1901160)2.75950933
85histone H4-K5 acetylation (GO:0043981)2.74487030
86histone H4-K8 acetylation (GO:0043982)2.74487030
87regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.71754492
88regulation of cilium movement (GO:0003352)2.70720156
89norepinephrine metabolic process (GO:0042415)2.69023104
90T cell differentiation involved in immune response (GO:0002292)2.69017195
91alpha-beta T cell differentiation involved in immune response (GO:0002293)2.69017195
92alpha-beta T cell activation involved in immune response (GO:0002287)2.69017195
93sympathetic nervous system development (GO:0048485)2.68446290
94nucleobase catabolic process (GO:0046113)2.66774438
95lens development in camera-type eye (GO:0002088)2.61369390
96G-protein coupled receptor internalization (GO:0002031)2.59595100
97positive regulation of gastrulation (GO:2000543)2.59217084
98kidney mesenchyme development (GO:0072074)2.56969435
99activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.56688359
100pyrimidine ribonucleoside catabolic process (GO:0046133)2.56149850

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.93510611
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse5.49838694
3GBX2_23144817_ChIP-Seq_PC3_Human4.94949118
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.80364993
5VDR_22108803_ChIP-Seq_LS180_Human3.50105445
6IGF1R_20145208_ChIP-Seq_DFB_Human2.97220132
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.93803238
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.74755568
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.60852663
10CBX2_27304074_Chip-Seq_ESCs_Mouse2.54417334
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.52212618
12DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.10889686
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.08295918
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.07342427
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05905041
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.05520716
17CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.99341007
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.94485369
19TAF15_26573619_Chip-Seq_HEK293_Human1.89882362
20PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86968941
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.85464829
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77647844
23AHR_22903824_ChIP-Seq_MCF-7_Human1.72899667
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.71320646
25TP63_19390658_ChIP-ChIP_HaCaT_Human1.62240334
26BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61382466
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.61124091
28RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55357627
29WT1_19549856_ChIP-ChIP_CCG9911_Human1.54998585
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.52764376
31P300_19829295_ChIP-Seq_ESCs_Human1.51871534
32ESR1_20079471_ChIP-ChIP_T-47D_Human1.51339601
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49945655
34ZNF274_21170338_ChIP-Seq_K562_Hela1.48386497
35ARNT_22903824_ChIP-Seq_MCF-7_Human1.47480836
36ESR1_21235772_ChIP-Seq_MCF-7_Human1.45536176
37WDR5_24793694_ChIP-Seq_LNCAP_Human1.45444783
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.45154559
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42682891
40IRF1_19129219_ChIP-ChIP_H3396_Human1.42347217
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39571316
42TDRD3_21172665_ChIP-Seq_MCF-7_Human1.34798166
43CBP_20019798_ChIP-Seq_JUKART_Human1.33015687
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33015687
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32788156
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.31753135
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30363505
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27857908
49JARID2_20064375_ChIP-Seq_MESCs_Mouse1.25289269
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24625643
51EWS_26573619_Chip-Seq_HEK293_Human1.20512266
52MYC_18940864_ChIP-ChIP_HL60_Human1.19466058
53RNF2_27304074_Chip-Seq_NSC_Mouse1.16425794
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.15558039
55KDM2B_26808549_Chip-Seq_REH_Human1.15146113
56REST_21632747_ChIP-Seq_MESCs_Mouse1.14820104
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14510053
58RXR_22108803_ChIP-Seq_LS180_Human1.13704251
59FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12103704
60SMAD4_21799915_ChIP-Seq_A2780_Human1.08956058
61KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07987055
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.07073243
63DROSHA_22980978_ChIP-Seq_HELA_Human1.06610264
64CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06046688
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05952201
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.05735740
67ER_23166858_ChIP-Seq_MCF-7_Human1.03411811
68KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02162194
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.01606326
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99617865
71STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99370565
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99357473
73TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97550401
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96106497
75SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95895210
76RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.95437712
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94956624
78AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94273212
79SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.94262330
80BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94157273
81ERG_20517297_ChIP-Seq_VCAP_Human0.93878488
82EZH2_27294783_Chip-Seq_ESCs_Mouse0.92912319
83SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92491807
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91891452
85FUS_26573619_Chip-Seq_HEK293_Human0.90443973
86EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.88265886
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88262610
88AR_21572438_ChIP-Seq_LNCaP_Human0.87416632
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85911672
90NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85555119
91PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83655479
92BCAT_22108803_ChIP-Seq_LS180_Human0.82487322
93P53_22387025_ChIP-Seq_ESCs_Mouse0.82107461
94TCF4_22108803_ChIP-Seq_LS180_Human0.81767942
95EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.81494034
96EZH2_18974828_ChIP-Seq_MESCs_Mouse0.81099012
97RNF2_18974828_ChIP-Seq_MESCs_Mouse0.81099012
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.80656065
99CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.80227230
100MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.79494175

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.82260434
2MP0009379_abnormal_foot_pigmentation6.66288129
3MP0003880_abnormal_central_pattern3.51600179
4MP0002277_abnormal_respiratory_mucosa3.31673042
5MP0002736_abnormal_nociception_after3.08429409
6MP0003283_abnormal_digestive_organ3.07672126
7MP0005174_abnormal_tail_pigmentation2.94159681
8MP0000015_abnormal_ear_pigmentation2.93185597
9MP0003011_delayed_dark_adaptation2.80629014
10MP0003646_muscle_fatigue2.69729075
11MP0001905_abnormal_dopamine_level2.68527056
12MP0000372_irregular_coat_pigmentation2.55819238
13MP0008789_abnormal_olfactory_epithelium2.25322644
14MP0001968_abnormal_touch/_nociception2.12224289
15MP0001873_stomach_inflammation1.83138063
16MP0004133_heterotaxia1.81032317
17MP0001986_abnormal_taste_sensitivity1.75696243
18MP0000534_abnormal_ureter_morphology1.75320042
19MP0002184_abnormal_innervation1.74383852
20MP0002638_abnormal_pupillary_reflex1.64301191
21MP0001188_hyperpigmentation1.62307110
22MP0002095_abnormal_skin_pigmentation1.62186214
23MP0005394_taste/olfaction_phenotype1.52702217
24MP0005499_abnormal_olfactory_system1.52702217
25MP0004130_abnormal_muscle_cell1.50804111
26MP0001485_abnormal_pinna_reflex1.38275735
27MP0003136_yellow_coat_color1.36972809
28MP0002751_abnormal_autonomic_nervous1.36231398
29MP0002876_abnormal_thyroid_physiology1.36210066
30MP0004270_analgesia1.35819249
31MP0003385_abnormal_body_wall1.30568634
32MP0005171_absent_coat_pigmentation1.25957230
33MP0002734_abnormal_mechanical_nocicepti1.24903084
34MP0000566_synostosis1.20736475
35MP0003252_abnormal_bile_duct1.20008157
36MP0009697_abnormal_copulation1.17478809
37MP0000778_abnormal_nervous_system1.17264924
38MP0005075_abnormal_melanosome_morpholog1.13861903
39MP0000427_abnormal_hair_cycle1.13104975
40MP0003632_abnormal_nervous_system1.12990129
41MP0009053_abnormal_anal_canal1.12159861
42MP0000462_abnormal_digestive_system1.11859289
43MP0005645_abnormal_hypothalamus_physiol1.11524851
44MP0009745_abnormal_behavioral_response1.10419509
45MP0000955_abnormal_spinal_cord1.08014176
46MP0001324_abnormal_eye_pigmentation1.04970896
47MP0000383_abnormal_hair_follicle1.04351529
48MP0002938_white_spotting1.04003126
49MP0001664_abnormal_digestion1.03989204
50MP0000467_abnormal_esophagus_morphology1.00047805
51MP0002102_abnormal_ear_morphology0.97434674
52MP0003942_abnormal_urinary_system0.96978274
53MP0002272_abnormal_nervous_system0.96166345
54MP0003950_abnormal_plasma_membrane0.95482715
55MP0002332_abnormal_exercise_endurance0.95460612
56MP0005409_darkened_coat_color0.94164145
57MP0002234_abnormal_pharynx_morphology0.94033603
58MP0003635_abnormal_synaptic_transmissio0.93782724
59MP0005266_abnormal_metabolism0.91941224
60MP0004145_abnormal_muscle_electrophysio0.91463807
61MP0003186_abnormal_redox_activity0.89627588
62MP0002064_seizures0.89299952
63MP0003959_abnormal_lean_body0.89242777
64MP0002067_abnormal_sensory_capabilities0.86909361
65MP0003119_abnormal_digestive_system0.85260154
66MP0002108_abnormal_muscle_morphology0.81378982
67MP0000049_abnormal_middle_ear0.81153730
68MP0005448_abnormal_energy_balance0.81076517
69MP0004883_abnormal_blood_vessel0.78925337
70MP0005503_abnormal_tendon_morphology0.78898581
71MP0003937_abnormal_limbs/digits/tail_de0.77877879
72MP0003195_calcinosis0.77664342
73MP0004142_abnormal_muscle_tone0.77025358
74MP0002233_abnormal_nose_morphology0.75390083
75MP0002127_abnormal_cardiovascular_syste0.74955304
76MP0000428_abnormal_craniofacial_morphol0.74614417
77MP0000470_abnormal_stomach_morphology0.74111737
78MP0006292_abnormal_olfactory_placode0.73637809
79MP0002282_abnormal_trachea_morphology0.72843938
80MP0000465_gastrointestinal_hemorrhage0.71913209
81MP0003315_abnormal_perineum_morphology0.68814760
82MP0005423_abnormal_somatic_nervous0.68543270
83MP0002653_abnormal_ependyma_morphology0.67739401
84MP0003936_abnormal_reproductive_system0.66577731
85MP0004811_abnormal_neuron_physiology0.64878630
86MP0005085_abnormal_gallbladder_physiolo0.64736008
87MP0006276_abnormal_autonomic_nervous0.62512015
88MP0000631_abnormal_neuroendocrine_gland0.62093395
89MP0008995_early_reproductive_senescence0.61531109
90MP0005083_abnormal_biliary_tract0.59539013
91MP0003938_abnormal_ear_development0.59309381
92MP0002928_abnormal_bile_duct0.58605586
93MP0003638_abnormal_response/metabolism_0.58241974
94MP0002177_abnormal_outer_ear0.57016716
95MP0003943_abnormal_hepatobiliary_system0.56420136
96MP0002882_abnormal_neuron_morphology0.55277279
97MP0003137_abnormal_impulse_conducting0.54278065
98MP0001765_abnormal_ion_homeostasis0.51789204
99MP0008961_abnormal_basal_metabolism0.50681476
100MP0000639_abnormal_adrenal_gland0.49550118

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.99437102
2Parakeratosis (HP:0001036)6.38211361
3Chronic bronchitis (HP:0004469)4.56538571
4Acanthocytosis (HP:0001927)4.44379014
5Maternal diabetes (HP:0009800)4.09627129
6Congenital, generalized hypertrichosis (HP:0004540)4.01054279
7Bony spicule pigmentary retinopathy (HP:0007737)3.69576760
8Abnormal respiratory motile cilium physiology (HP:0012261)3.69043333
9Myelomeningocele (HP:0002475)3.60003726
10Tubulointerstitial nephritis (HP:0001970)3.57727966
11Constricted visual fields (HP:0001133)3.42887967
12Hyperlipoproteinemia (HP:0010980)3.40745206
13Adrenal hypoplasia (HP:0000835)3.37189597
14Absent rod-and cone-mediated responses on ERG (HP:0007688)3.22162874
15Aplasia/Hypoplasia of the sacrum (HP:0008517)3.19046559
16Severe visual impairment (HP:0001141)2.90277185
17Partial agenesis of the corpus callosum (HP:0001338)2.88130903
18Rhinitis (HP:0012384)2.87724958
19Aplasia of the musculature (HP:0100854)2.87492997
20Septo-optic dysplasia (HP:0100842)2.77814860
21Distal arthrogryposis (HP:0005684)2.77643857
22Increased hepatocellular lipid droplets (HP:0006565)2.70903343
23Abnormal rod and cone electroretinograms (HP:0008323)2.68629965
24Renal cortical cysts (HP:0000803)2.63165678
25Concave nail (HP:0001598)2.57087608
26Bronchitis (HP:0012387)2.54768610
27Absent phalangeal crease (HP:0006109)2.51219796
28Choroideremia (HP:0001139)2.50381687
29Type II lissencephaly (HP:0007260)2.50062632
30Calf muscle hypertrophy (HP:0008981)2.49086880
31Increased intramyocellular lipid droplets (HP:0012240)2.48980545
32Long nose (HP:0003189)2.46532795
33Muscle hypertrophy of the lower extremities (HP:0008968)2.45853378
34Severe combined immunodeficiency (HP:0004430)2.45433589
35Nuclear cataract (HP:0100018)2.40230222
36Abnormality of B cell number (HP:0010975)2.39772165
37Abnormality of the axillary hair (HP:0100134)2.39261516
38Abnormality of secondary sexual hair (HP:0009888)2.39261516
39Esophageal atresia (HP:0002032)2.38508264
40Abnormal number of incisors (HP:0011064)2.38246005
41Slender build (HP:0001533)2.34813648
42Anterior segment dysgenesis (HP:0007700)2.31536141
43Abnormality of incisor morphology (HP:0011063)2.30880256
44Spinal muscular atrophy (HP:0007269)2.30760018
45Thyroiditis (HP:0100646)2.27255660
46Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.26078282
47Epidermoid cyst (HP:0200040)2.24737948
48Irregular vertebral endplates (HP:0003301)2.19506306
49Lipid accumulation in hepatocytes (HP:0006561)2.18933102
50Severe muscular hypotonia (HP:0006829)2.17052471
51Abnormality of the vertebral endplates (HP:0005106)2.16677012
52Renal Fanconi syndrome (HP:0001994)2.15905846
53Tubulointerstitial abnormality (HP:0001969)2.15401146
54Ulnar claw (HP:0001178)2.13681827
55Aplasia/Hypoplasia involving the musculature (HP:0001460)2.07564100
56Focal seizures (HP:0007359)2.06250373
57Meningocele (HP:0002435)2.04705829
58Abnormal finger flexion creases (HP:0006143)2.04294253
59Absent thumb (HP:0009777)2.02284683
60Poikilocytosis (HP:0004447)2.01884445
61Sparse lateral eyebrow (HP:0005338)1.98571361
62Respiratory difficulties (HP:0002880)1.98516703
63Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.96470218
64Shawl scrotum (HP:0000049)1.96175577
65Paralysis (HP:0003470)1.95874988
66Pachygyria (HP:0001302)1.92056584
67Poor head control (HP:0002421)1.90762788
68Facial hemangioma (HP:0000329)1.89021592
69Autoimmune hemolytic anemia (HP:0001890)1.88549208
70Increased neuronal autofluorescent lipopigment (HP:0002074)1.88420588
71Hypoplastic pelvis (HP:0008839)1.88183041
72Increased muscle lipid content (HP:0009058)1.88071160
73Congenital ichthyosiform erythroderma (HP:0007431)1.87420645
74Anencephaly (HP:0002323)1.85691343
75B lymphocytopenia (HP:0010976)1.85546233
76Muscle fiber inclusion bodies (HP:0100299)1.82596387
77Cerebral palsy (HP:0100021)1.81442142
78Reduced subcutaneous adipose tissue (HP:0003758)1.81083447
79Mesangial abnormality (HP:0001966)1.80618111
80Abnormality of cells of the erythroid lineage (HP:0012130)1.80229759
81Erythroderma (HP:0001019)1.78944087
82Dialeptic seizures (HP:0011146)1.78847344
83Combined immunodeficiency (HP:0005387)1.78552831
84Abnormality of renal resorption (HP:0011038)1.78474746
85Progressive microcephaly (HP:0000253)1.78440514
86Conical tooth (HP:0000698)1.75877487
87Decreased subcutaneous fat (HP:0001002)1.75369379
88Exertional dyspnea (HP:0002875)1.75315130
89Waddling gait (HP:0002515)1.74500869
90Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74275718
91Pancreatic cysts (HP:0001737)1.73593269
92Segmental peripheral demyelination/remyelination (HP:0003481)1.73442053
93Nemaline bodies (HP:0003798)1.71913314
94Glycosuria (HP:0003076)1.71747171
95Abnormality of urine glucose concentration (HP:0011016)1.71747171
96Absent septum pellucidum (HP:0001331)1.70089668
97Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.69931638
98Difficulty walking (HP:0002355)1.69531354
99Cerebellar hypoplasia (HP:0001321)1.69303142
100Amniotic constriction ring (HP:0009775)1.69046759

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK3.73562408
2PINK13.46013354
3BMPR1B3.18367248
4MAP3K123.09843090
5NME13.00979538
6EPHA42.88705895
7DYRK22.83561834
8TAOK32.69249757
9TGFBR12.68405597
10ICK2.19487092
11MAP3K92.03181701
12NEK12.00216509
13GRK11.95707458
14OBSCN1.92623983
15PHKG11.72445523
16PHKG21.72445523
17MAP3K111.68328999
18CDK91.66819711
19CDK81.65309664
20ADRBK21.65293310
21TRPM71.64617505
22WNK41.59423897
23PDGFRB1.47277375
24ERBB41.42814647
25MAP4K21.41336949
26LRRK21.40947151
27PAK21.37398800
28MAP2K61.36834319
29MARK11.34141294
30MKNK21.33077678
31MKNK11.27133333
32MAP2K41.22735139
33TLK11.19741442
34CAMK2B1.13978119
35SIK21.11537543
36BRSK21.08093680
37MAP2K21.04563970
38GRK61.01729888
39FLT31.01270236
40STK390.98471596
41MAPK130.98129685
42FRK0.91211674
43PRKAA20.90693695
44BTK0.87892589
45ERBB30.86607226
46DYRK30.86000732
47ACVR1B0.84392428
48CAMK1D0.83845817
49PAK30.78540637
50NEK20.78237672
51KDR0.74030310
52DYRK1A0.73449747
53CAMK2A0.72667958
54ZAK0.72027034
55PKN20.70529403
56CAMK2G0.70497296
57TXK0.69720223
58LIMK10.69706668
59CAMKK10.68734819
60CAMK1G0.68387359
61CAMK2D0.66580260
62PRKCZ0.65748818
63MAP2K10.64992738
64ABL20.63543121
65INSRR0.63069475
66KSR10.63043166
67WNK10.62711048
68GSK3A0.61531539
69PIK3CG0.58786756
70CAMKK20.58194358
71PIM10.56184921
72CAMK40.55982678
73ERBB20.54412586
74CHUK0.53933345
75YES10.53911106
76ABL10.52822524
77MAPKAPK50.51974926
78PLK40.50269499
79ADRBK10.50246945
80MARK30.48669962
81SYK0.47901741
82PRKCQ0.47101913
83MUSK0.46754152
84TGFBR20.45551629
85OXSR10.44606168
86PNCK0.43891131
87IGF1R0.42095742
88PRKCE0.41920311
89PRKACA0.41839591
90CLK10.36959912
91CSK0.35701715
92PRKG10.35487247
93CDK30.34885168
94MINK10.34721727
95TEC0.33757949
96PRKCG0.33062068
97PRKCH0.32757960
98NTRK30.31170706
99GRK70.30571330
100MYLK0.30301982

Predicted pathways (KEGG)

RankGene SetZ-score
1Parkinsons disease_Homo sapiens_hsa050123.92134877
2Ribosome_Homo sapiens_hsa030103.15598254
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.05784995
4Protein export_Homo sapiens_hsa030603.03627373
5Selenocompound metabolism_Homo sapiens_hsa004502.77857096
6Cardiac muscle contraction_Homo sapiens_hsa042602.45089145
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.38643531
8Steroid biosynthesis_Homo sapiens_hsa001002.29764008
9Oxidative phosphorylation_Homo sapiens_hsa001902.15985440
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.10675500
11Alzheimers disease_Homo sapiens_hsa050101.95577953
12Butanoate metabolism_Homo sapiens_hsa006501.92697048
13Huntingtons disease_Homo sapiens_hsa050161.85996289
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.65611219
15Nicotine addiction_Homo sapiens_hsa050331.65132759
16African trypanosomiasis_Homo sapiens_hsa051431.59909684
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59676095
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.56948388
19Graft-versus-host disease_Homo sapiens_hsa053321.52918779
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52135098
21Taste transduction_Homo sapiens_hsa047421.44404573
22Tryptophan metabolism_Homo sapiens_hsa003801.42167236
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.40346039
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.35650181
25Proteasome_Homo sapiens_hsa030501.32277190
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.31631720
27RNA degradation_Homo sapiens_hsa030181.29485713
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25812180
29Gastric acid secretion_Homo sapiens_hsa049711.21072573
30Nitrogen metabolism_Homo sapiens_hsa009101.14761546
31Morphine addiction_Homo sapiens_hsa050321.14731961
32Calcium signaling pathway_Homo sapiens_hsa040201.11556549
33GABAergic synapse_Homo sapiens_hsa047271.05617617
34Retinol metabolism_Homo sapiens_hsa008301.04676935
35ABC transporters_Homo sapiens_hsa020101.03929820
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01285100
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00433075
38beta-Alanine metabolism_Homo sapiens_hsa004100.97420087
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94646608
40Circadian rhythm_Homo sapiens_hsa047100.93000729
41Malaria_Homo sapiens_hsa051440.91360406
42Insulin secretion_Homo sapiens_hsa049110.90857315
43Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.89211489
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87595725
45Cocaine addiction_Homo sapiens_hsa050300.86528556
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86411769
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.84378896
48Circadian entrainment_Homo sapiens_hsa047130.82900813
49Regulation of autophagy_Homo sapiens_hsa041400.81123467
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81051104
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80793102
52Olfactory transduction_Homo sapiens_hsa047400.79134666
53Serotonergic synapse_Homo sapiens_hsa047260.78338246
54Starch and sucrose metabolism_Homo sapiens_hsa005000.77196451
55Axon guidance_Homo sapiens_hsa043600.74381879
56Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74088525
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73222783
58Systemic lupus erythematosus_Homo sapiens_hsa053220.70105598
59Glutamatergic synapse_Homo sapiens_hsa047240.66327725
60Chemical carcinogenesis_Homo sapiens_hsa052040.65569298
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65390661
62Hedgehog signaling pathway_Homo sapiens_hsa043400.65369421
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63317899
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63160629
65p53 signaling pathway_Homo sapiens_hsa041150.61917949
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60872431
67T cell receptor signaling pathway_Homo sapiens_hsa046600.60031900
68Notch signaling pathway_Homo sapiens_hsa043300.60019707
69Phototransduction_Homo sapiens_hsa047440.58624171
70Dopaminergic synapse_Homo sapiens_hsa047280.56258769
71Legionellosis_Homo sapiens_hsa051340.54432745
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.54354203
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53167372
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.52748587
75Spliceosome_Homo sapiens_hsa030400.51894654
76Linoleic acid metabolism_Homo sapiens_hsa005910.51691355
77Fat digestion and absorption_Homo sapiens_hsa049750.48648523
78Basal cell carcinoma_Homo sapiens_hsa052170.48509299
79Primary immunodeficiency_Homo sapiens_hsa053400.48426085
80Peroxisome_Homo sapiens_hsa041460.47877590
81Oxytocin signaling pathway_Homo sapiens_hsa049210.47106068
82Hematopoietic cell lineage_Homo sapiens_hsa046400.46335189
83Fatty acid metabolism_Homo sapiens_hsa012120.45788147
84TNF signaling pathway_Homo sapiens_hsa046680.45261506
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.43454452
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43443166
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42989747
88Dilated cardiomyopathy_Homo sapiens_hsa054140.42822602
89Amphetamine addiction_Homo sapiens_hsa050310.39283980
90Thyroid hormone synthesis_Homo sapiens_hsa049180.38359373
91Wnt signaling pathway_Homo sapiens_hsa043100.37466465
92Autoimmune thyroid disease_Homo sapiens_hsa053200.36537134
93Allograft rejection_Homo sapiens_hsa053300.35442816
94Propanoate metabolism_Homo sapiens_hsa006400.35004434
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34647710
96Renin secretion_Homo sapiens_hsa049240.33999109
97Fatty acid degradation_Homo sapiens_hsa000710.32949056
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32783064
99Fatty acid elongation_Homo sapiens_hsa000620.32193758
100Glycerolipid metabolism_Homo sapiens_hsa005610.31064873

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