WWP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.26885498
2negative regulation of cell killing (GO:0031342)5.26885498
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.07377530
4ribosomal small subunit assembly (GO:0000028)4.63986911
5positive regulation by symbiont of host defense response (GO:0052509)4.51949964
6modulation by symbiont of host defense response (GO:0052031)4.51949964
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.51949964
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.51949964
9positive regulation by organism of defense response of other organism involved in symbiotic interact4.51949964
10modulation by symbiont of host immune response (GO:0052553)4.51949964
11detection of other organism (GO:0098543)4.31432404
12neutrophil activation involved in immune response (GO:0002283)4.17829466
13detection of bacterium (GO:0016045)4.17108668
14response to peptidoglycan (GO:0032494)4.14765627
15macrophage activation involved in immune response (GO:0002281)3.97739459
16regulation of B cell receptor signaling pathway (GO:0050855)3.81584502
17detection of external biotic stimulus (GO:0098581)3.74361533
18detection of molecule of bacterial origin (GO:0032490)3.62166720
19viral transcription (GO:0019083)3.52718035
20translational termination (GO:0006415)3.44300062
21negative regulation of lymphocyte mediated immunity (GO:0002707)3.41778449
22negative regulation of interleukin-12 production (GO:0032695)3.38763232
23response to muramyl dipeptide (GO:0032495)3.34719096
24regulation of interferon-beta biosynthetic process (GO:0045357)3.33026276
25regulation of mast cell degranulation (GO:0043304)3.32124422
26germinal center formation (GO:0002467)3.31489458
27detection of biotic stimulus (GO:0009595)3.28470799
28regulation of leukocyte degranulation (GO:0043300)3.25004518
29neutrophil activation (GO:0042119)3.24044539
30maturation of SSU-rRNA (GO:0030490)3.22512781
31regulation of myeloid leukocyte mediated immunity (GO:0002886)3.21924526
32formation of translation preinitiation complex (GO:0001731)3.21295700
33response to interleukin-15 (GO:0070672)3.16951516
34negative regulation of leukocyte mediated immunity (GO:0002704)3.16642473
35antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.14222492
36antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.14222492
37mannose metabolic process (GO:0006013)3.13726492
38negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.12709541
39response to host immune response (GO:0052572)3.12089902
40response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.12089902
41positive regulation of Cdc42 GTPase activity (GO:0043089)3.08535081
42translational elongation (GO:0006414)3.06930473
43protein localization to kinetochore (GO:0034501)3.06631517
44respiratory burst (GO:0045730)3.05106320
45positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.03991553
46B cell receptor signaling pathway (GO:0050853)3.03814273
47granulocyte activation (GO:0036230)3.03549299
48negative thymic T cell selection (GO:0045060)3.03247181
49regulation of dendritic cell antigen processing and presentation (GO:0002604)2.98409155
50positive regulation of gamma-delta T cell activation (GO:0046645)2.97257181
51macrophage activation (GO:0042116)2.96704643
52response to host (GO:0075136)2.96471323
53response to host defenses (GO:0052200)2.96471323
54response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.96471323
55regulation of mast cell activation involved in immune response (GO:0033006)2.93234378
56positive regulation of cellular amide metabolic process (GO:0034250)2.92954886
57regulation of T-helper 2 cell differentiation (GO:0045628)2.91540823
58response to type I interferon (GO:0034340)2.91213863
59myeloid cell activation involved in immune response (GO:0002275)2.90445647
60cellular response to type I interferon (GO:0071357)2.89366466
61type I interferon signaling pathway (GO:0060337)2.89366466
62antigen processing and presentation via MHC class Ib (GO:0002475)2.88289732
63keratan sulfate catabolic process (GO:0042340)2.87036542
64thymic T cell selection (GO:0045061)2.86709126
65nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.86590040
66antigen processing and presentation of endogenous antigen (GO:0019883)2.84280864
67translational initiation (GO:0006413)2.83919302
68negative T cell selection (GO:0043383)2.83126419
69SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.80892381
70lipopolysaccharide-mediated signaling pathway (GO:0031663)2.80186811
71mitotic nuclear envelope disassembly (GO:0007077)2.77477345
72T cell selection (GO:0045058)2.77449070
73negative regulation of innate immune response (GO:0045824)2.77370303
74regulation of regulated secretory pathway (GO:1903305)2.77233723
75cellular response to interleukin-15 (GO:0071350)2.75730313
76NIK/NF-kappaB signaling (GO:0038061)2.74612890
77negative regulation of interleukin-6 production (GO:0032715)2.70973523
78regulation of T cell tolerance induction (GO:0002664)2.70777070
79regulation of tolerance induction (GO:0002643)2.70550274
80protein targeting to ER (GO:0045047)2.70315492
81regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.70277767
82viral life cycle (GO:0019058)2.69791313
83interferon-gamma-mediated signaling pathway (GO:0060333)2.69716707
84DNA unwinding involved in DNA replication (GO:0006268)2.69715197
85negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.69710668
86negative regulation of T cell mediated immunity (GO:0002710)2.69413809
87ribosomal small subunit biogenesis (GO:0042274)2.69375103
88regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.69335014
89leukocyte migration involved in inflammatory response (GO:0002523)2.67996793
90positive regulation of mast cell activation (GO:0033005)2.67935510
91cellular protein complex disassembly (GO:0043624)2.66807479
92cotranslational protein targeting to membrane (GO:0006613)2.66796976
93microglial cell activation (GO:0001774)2.66231245
94tolerance induction (GO:0002507)2.63133740
95regulation of mast cell activation (GO:0033003)2.61899989
96negative regulation of toll-like receptor signaling pathway (GO:0034122)2.61659180
97positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.60759356
98neutrophil mediated immunity (GO:0002446)2.60290816
99protein localization to chromosome, centromeric region (GO:0071459)2.60205851
100regulation of B cell differentiation (GO:0045577)2.59024104
101histone H3-K36 demethylation (GO:0070544)2.56857971
102nuclear envelope disassembly (GO:0051081)2.56023590
103membrane disassembly (GO:0030397)2.56023590
104regulation of gamma-delta T cell differentiation (GO:0045586)2.55817470
105establishment of protein localization to endoplasmic reticulum (GO:0072599)2.55601304
106protein complex disassembly (GO:0043241)2.54837025
107positive T cell selection (GO:0043368)2.54619225
108positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.54585820
109nuclear pore organization (GO:0006999)2.53771107
110regulation of spindle organization (GO:0090224)2.53181021
111defense response to protozoan (GO:0042832)2.53066630
112nuclear pore complex assembly (GO:0051292)2.51985097
113regulation of integrin activation (GO:0033623)2.51913653
114regulation of ARF protein signal transduction (GO:0032012)2.51259831
115production of molecular mediator involved in inflammatory response (GO:0002532)2.51149165
116T cell apoptotic process (GO:0070231)2.51116912
117regulation of translational fidelity (GO:0006450)2.48427671
118regulation of necroptotic process (GO:0060544)2.48319103
119regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.47786842
120regulation of natural killer cell mediated immunity (GO:0002715)2.47786842
121DNA strand elongation involved in DNA replication (GO:0006271)2.47111962
122protein localization to endoplasmic reticulum (GO:0070972)2.46338054
123cellular extravasation (GO:0045123)2.45491649
124positive regulation of type 2 immune response (GO:0002830)2.45117685
125DNA replication-dependent nucleosome organization (GO:0034723)2.44891391
126DNA replication-dependent nucleosome assembly (GO:0006335)2.44891391
127dosage compensation (GO:0007549)2.44485483
128IMP biosynthetic process (GO:0006188)2.44141328
129regulation of gamma-delta T cell activation (GO:0046643)2.44023750
130negative regulation of phagocytosis (GO:0050765)2.39877408
131immunoglobulin mediated immune response (GO:0016064)2.38813283
132positive regulation of SMAD protein import into nucleus (GO:0060391)2.36460113
133translesion synthesis (GO:0019985)2.35879004
134DNA strand elongation (GO:0022616)2.35577969
135Golgi transport vesicle coating (GO:0048200)2.34860275
136COPI coating of Golgi vesicle (GO:0048205)2.34860275
137spliceosomal tri-snRNP complex assembly (GO:0000244)2.34704289
138macromolecular complex disassembly (GO:0032984)2.33688511
139Arp2/3 complex-mediated actin nucleation (GO:0034314)2.31468393
140mitotic chromosome condensation (GO:0007076)2.29372726
141telomere maintenance via semi-conservative replication (GO:0032201)2.26815515
142regulation of SMAD protein import into nucleus (GO:0060390)2.24467835
1433-UTR-mediated mRNA stabilization (GO:0070935)2.23552107
144positive regulation of protein import into nucleus, translocation (GO:0033160)2.22143355
145regulation of mitotic spindle organization (GO:0060236)2.21603338
146mitotic sister chromatid segregation (GO:0000070)2.19558196
147regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.18952114
148B cell mediated immunity (GO:0019724)2.18412619
149chromosome condensation (GO:0030261)2.18380453
150regulation of interleukin-12 biosynthetic process (GO:0045075)2.18051637
151folic acid-containing compound biosynthetic process (GO:0009396)2.17902524
152nuclear-transcribed mRNA catabolic process (GO:0000956)2.16000090
153ribosomal large subunit biogenesis (GO:0042273)2.15698517
154cellular response to epidermal growth factor stimulus (GO:0071364)2.15494668
155nucleobase biosynthetic process (GO:0046112)2.14722795
156DNA replication initiation (GO:0006270)2.14594774
157sister chromatid segregation (GO:0000819)2.13593966
158positive regulation of extracellular matrix organization (GO:1903055)2.13577660
159negative regulation of erythrocyte differentiation (GO:0045647)2.12662124
160negative regulation of histone methylation (GO:0031061)2.12619567
161regulation of protein heterodimerization activity (GO:0043497)2.12577513
162hepatocyte apoptotic process (GO:0097284)2.12480533
163pore complex assembly (GO:0046931)2.08117617
164DNA duplex unwinding (GO:0032508)2.07311659
165purine nucleobase biosynthetic process (GO:0009113)2.07037425
166leukocyte aggregation (GO:0070486)2.06716350
167mRNA catabolic process (GO:0006402)2.06673359
168DNA geometric change (GO:0032392)2.06579695
169collagen fibril organization (GO:0030199)2.04746300
170IMP metabolic process (GO:0046040)2.04274583
171RNA catabolic process (GO:0006401)2.04218649
172endothelial tube morphogenesis (GO:0061154)2.03936817
173morphogenesis of an endothelium (GO:0003159)2.03936817
174nuclear envelope organization (GO:0006998)2.03314786
175positive regulation of B cell differentiation (GO:0045579)2.02543307
176positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.02207938
177positive thymic T cell selection (GO:0045059)2.01324157
178endodermal cell differentiation (GO:0035987)2.00483889
179germ cell migration (GO:0008354)2.00405513
180lymphocyte apoptotic process (GO:0070227)1.98548976
181chromatin assembly (GO:0031497)1.98540865
182telomere maintenance via recombination (GO:0000722)1.97514694
183ncRNA 3-end processing (GO:0043628)1.97182030
184pre-miRNA processing (GO:0031054)1.96500538

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.18454502
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.51178115
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.18924442
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.10296330
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.94680508
6MYC_22102868_ChIP-Seq_BL_Human2.65013137
7KDM2B_26808549_Chip-Seq_SUP-B15_Human2.40477571
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.39902669
9VDR_21846776_ChIP-Seq_THP-1_Human2.32261417
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.25025582
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.18550399
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.15130813
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.14474039
14SPI1_23127762_ChIP-Seq_K562_Human2.13922766
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.12996361
16LXR_22292898_ChIP-Seq_THP-1_Human2.12104990
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.07147065
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.05502230
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02990789
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.02808188
21MYC_19079543_ChIP-ChIP_MESCs_Mouse1.95514898
22RUNX_20019798_ChIP-Seq_JUKART_Human1.84425904
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.84289283
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.82702705
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.82607943
26* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.76080291
27GATA1_19941827_ChIP-Seq_MEL_Mouse1.72730780
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.70109535
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.67449975
30SCL_19346495_ChIP-Seq_HPC-7_Human1.65204434
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64523324
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64008459
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.62505850
34* ESR2_21235772_ChIP-Seq_MCF-7_Human1.62496077
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61036880
36RACK7_27058665_Chip-Seq_MCF-7_Human1.60866039
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.56348847
38MAF_26560356_Chip-Seq_TH1_Human1.55031865
39TCF7_22412390_ChIP-Seq_EML_Mouse1.54741996
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.52137737
41* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.51068908
42SPI1_23547873_ChIP-Seq_NB4_Human1.50187580
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.48969188
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48483460
45VDR_24763502_ChIP-Seq_THP-1_Human1.48337237
46UTX_26944678_Chip-Seq_JUKART_Human1.48289970
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.47616014
48IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.47155670
49CIITA_25753668_ChIP-Seq_RAJI_Human1.46929691
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46111633
51XRN2_22483619_ChIP-Seq_HELA_Human1.44601207
52RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.44482873
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.43921109
54* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.43157384
55STAT3_1855785_ChIP-Seq_MESCs_Mouse1.42449219
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.40989319
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.40319492
58MYB_26560356_Chip-Seq_TH2_Human1.39746748
59GATA1_19941826_ChIP-Seq_K562_Human1.39469479
60KDM2B_26808549_Chip-Seq_K562_Human1.37111223
61TP63_19390658_ChIP-ChIP_HaCaT_Human1.36910687
62STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.36726889
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34186649
64CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33709002
65NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31677202
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31299105
67* TFEB_21752829_ChIP-Seq_HELA_Human1.30728654
68* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30539342
69KDM2B_26808549_Chip-Seq_JURKAT_Human1.30167714
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.29809683
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27894594
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.27659566
73AR_21909140_ChIP-Seq_LNCAP_Human1.27334534
74* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26830633
75MYB_26560356_Chip-Seq_TH1_Human1.26725607
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25067264
77CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22427260
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22338328
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22040325
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21531729
81EST1_17652178_ChIP-ChIP_JURKAT_Human1.21444159
82SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.20957670
83VDR_24787735_ChIP-Seq_THP-1_Human1.20854555
84PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20842062
85LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19703724
86BCOR_27268052_Chip-Seq_Bcells_Human1.19199249
87SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18947686
88PPARA_22158963_ChIP-Seq_LIVER_Mouse1.18832604
89GATA2_21666600_ChIP-Seq_HMVEC_Human1.17317332
90RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16839259
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16768651
92SMC4_20622854_ChIP-Seq_HELA_Human1.16400075
93ETS1_20019798_ChIP-Seq_JURKAT_Human1.15953698
94STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15683393
95P68_20966046_ChIP-Seq_HELA_Human1.15262043
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14551586
97VDR_23849224_ChIP-Seq_CD4+_Human1.13320812
98E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13225605
99PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12843989
100KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12399579
101FOXP3_21729870_ChIP-Seq_TREG_Human1.12310312
102GATA3_27048872_Chip-Seq_THYMUS_Human1.11239529
103* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10463524
104BCL6_27268052_Chip-Seq_Bcells_Human1.09909947
105POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09693290
106KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08333143
107RUNX1_27514584_Chip-Seq_MCF-7_Human1.07940062
108HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07435866
109CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07355810
110GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07290897
111DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07136297
112SA1_27219007_Chip-Seq_ERYTHROID_Human1.06995719
113FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.05366152
114IRF8_27001747_Chip-Seq_BMDM_Mouse1.04252809
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04125358
116KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03868012
117* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03756312
118GATA2_19941826_ChIP-Seq_K562_Human1.03626667
119CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03537452
120NCOR1_26117541_ChIP-Seq_K562_Human1.03314573
121SMAD_19615063_ChIP-ChIP_OVARY_Human1.03263086
122KDM2B_26808549_Chip-Seq_DND41_Human1.03196226
123RXR_22158963_ChIP-Seq_LIVER_Mouse1.03066997
124CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03036873
125FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.02547689
126RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02311534
127GATA1_22025678_ChIP-Seq_K562_Human1.02067624
128KDM5A_27292631_Chip-Seq_BREAST_Human1.01782656
129HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01470665
130GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01365913
131* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01233306
132RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01016672
133ATF3_27146783_Chip-Seq_COLON_Human1.00998333
134* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00797275
135TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99571064
136CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99350764
137PU_27001747_Chip-Seq_BMDM_Mouse0.99279115
138GABP_19822575_ChIP-Seq_HepG2_Human0.99128588
139E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98975562
140RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97946056
141* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97721317
142TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97467735
143FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.97034699
144ELF1_20517297_ChIP-Seq_JURKAT_Human0.96460554
145MAF_26560356_Chip-Seq_TH2_Human0.96432714
146SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96177763
147PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95936499
148ELF1_17652178_ChIP-ChIP_JURKAT_Human0.95543826
149ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95022211
150* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94140938
151STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.94015344
152* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93717322
153DCP1A_22483619_ChIP-Seq_HELA_Human0.93700164

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003191_abnormal_cellular_cholesterol2.60639114
2MP0003705_abnormal_hypodermis_morpholog2.47876542
3MP0009278_abnormal_bone_marrow2.47703014
4MP0005451_abnormal_body_composition2.45078337
5MP0008260_abnormal_autophagy2.30429263
6MP0002396_abnormal_hematopoietic_system2.23618432
7MP0010352_gastrointestinal_tract_polyps2.15553170
8MP0003436_decreased_susceptibility_to2.10690174
9MP0003693_abnormal_embryo_hatching2.06861138
10MP0006082_CNS_inflammation2.06573207
11MP0003111_abnormal_nucleus_morphology2.00183925
12MP0005076_abnormal_cell_differentiation1.97874750
13MP0003866_abnormal_defecation1.85444247
14MP0001849_ear_inflammation1.84218057
15MP0008438_abnormal_cutaneous_collagen1.80932688
16MP0003183_abnormal_peptide_metabolism1.80923510
17MP0005023_abnormal_wound_healing1.79836678
18MP0004808_abnormal_hematopoietic_stem1.77560073
19MP0003566_abnormal_cell_adhesion1.76003372
20MP0010094_abnormal_chromosome_stability1.72117627
21MP0006054_spinal_hemorrhage1.71240005
22MP0003077_abnormal_cell_cycle1.68372284
23MP0000465_gastrointestinal_hemorrhage1.68278558
24MP0002933_joint_inflammation1.65158531
25MP0004957_abnormal_blastocyst_morpholog1.63815313
26MP0005503_abnormal_tendon_morphology1.61169571
27MP0001958_emphysema1.60895454
28MP0000569_abnormal_digit_pigmentation1.60211416
29MP0003828_pulmonary_edema1.60093476
30MP0004381_abnormal_hair_follicle1.59959522
31MP0002132_abnormal_respiratory_system1.59438969
32MP0009840_abnormal_foam_cell1.59015254
33MP0000685_abnormal_immune_system1.56786802
34MP0005397_hematopoietic_system_phenotyp1.56408929
35MP0001545_abnormal_hematopoietic_system1.56408929
36MP0001835_abnormal_antigen_presentation1.55563828
37MP0002282_abnormal_trachea_morphology1.48904894
38MP0010307_abnormal_tumor_latency1.47426183
39MP0000490_abnormal_crypts_of1.46943794
40MP0005310_abnormal_salivary_gland1.46585877
41MP0009053_abnormal_anal_canal1.42839878
42MP0005275_abnormal_skin_tensile1.41287423
43MP0005464_abnormal_platelet_physiology1.41073058
44MP0002998_abnormal_bone_remodeling1.40672352
45MP0001851_eye_inflammation1.40501927
46MP0001800_abnormal_humoral_immune1.38789621
47MP0001533_abnormal_skeleton_physiology1.37969950
48MP0002452_abnormal_antigen_presenting1.37796777
49MP0002398_abnormal_bone_marrow1.37582874
50MP0003763_abnormal_thymus_physiology1.36550741
51MP0000350_abnormal_cell_proliferation1.34084883
52MP0005000_abnormal_immune_tolerance1.33169408
53MP0008007_abnormal_cellular_replicative1.32162579
54MP0003279_aneurysm1.31523986
55MP0010030_abnormal_orbit_morphology1.30024027
56MP0003300_gastrointestinal_ulcer1.29917932
57MP0008469_abnormal_protein_level1.29806557
58MP0009333_abnormal_splenocyte_physiolog1.26854424
59MP0003075_altered_response_to1.26473917
60MP0004947_skin_inflammation1.25975578
61MP0009785_altered_susceptibility_to1.25784370
62MP0000858_altered_metastatic_potential1.24468331
63MP0005058_abnormal_lysosome_morphology1.23664825
64MP0002420_abnormal_adaptive_immunity1.21353313
65MP0002405_respiratory_system_inflammati1.21297438
66MP0001819_abnormal_immune_cell1.20778118
67MP0002722_abnormal_immune_system1.20456860
68MP0005390_skeleton_phenotype1.19360707
69MP0005025_abnormal_response_to1.18817274
70MP0002419_abnormal_innate_immunity1.17845223
71MP0000689_abnormal_spleen_morphology1.14839557
72MP0004883_abnormal_blood_vessel1.14140675
73MP0003448_altered_tumor_morphology1.13880056
74MP0010155_abnormal_intestine_physiology1.13127767
75MP0002723_abnormal_immune_serum1.11728549
76MP0000716_abnormal_immune_system1.11382184
77MP0000703_abnormal_thymus_morphology1.10112438
78MP0002429_abnormal_blood_cell1.09835284
79MP0005409_darkened_coat_color1.09666487
80MP0005174_abnormal_tail_pigmentation1.08989724
81MP0004134_abnormal_chest_morphology1.07941295
82MP0003091_abnormal_cell_migration1.07826933
83MP0004510_myositis1.07136605
84MP0001873_stomach_inflammation1.06978530
85MP0003656_abnormal_erythrocyte_physiolo1.06740076
86MP0003453_abnormal_keratinocyte_physiol1.05524952
87MP0004197_abnormal_fetal_growth/weight/1.05476268
88MP0003303_peritoneal_inflammation1.04882908
89MP0000428_abnormal_craniofacial_morphol1.04627785
90MP0001730_embryonic_growth_arrest1.04107944
91MP0008058_abnormal_DNA_repair1.03853208
92MP0001853_heart_inflammation1.03276854
93MP0005387_immune_system_phenotype1.02021346
94MP0001790_abnormal_immune_system1.02021346
95MP0003172_abnormal_lysosome_physiology1.01578969
96MP0003690_abnormal_glial_cell1.00538538
97MP0010234_abnormal_vibrissa_follicle1.00049139
98MP0002060_abnormal_skin_morphology1.00023467
99MP0005508_abnormal_skeleton_morphology0.99403915
100MP0002166_altered_tumor_susceptibility0.99064512
101MP0003567_abnormal_fetal_cardiomyocyte0.98411778
102MP0002019_abnormal_tumor_incidence0.97958864
103MP0004264_abnormal_extraembryonic_tissu0.97805695
104MP0005166_decreased_susceptibility_to0.97104142
105MP0004858_abnormal_nervous_system0.96986490
106MP0009764_decreased_sensitivity_to0.96280306
107MP0008057_abnormal_DNA_replication0.94952549
108MP0002086_abnormal_extraembryonic_tissu0.93730561
109MP0005164_abnormal_response_to0.93606839
110MP0000604_amyloidosis0.92515153
111MP0005671_abnormal_response_to0.92079402
112MP0003123_paternal_imprinting0.89698970
113MP0002115_abnormal_skeleton_extremities0.89657209
114MP0003045_fibrosis0.87701809
115MP0003795_abnormal_bone_structure0.87365335
116MP0002113_abnormal_skeleton_development0.87129832
117MP0000733_abnormal_muscle_development0.86771165
118MP0001845_abnormal_inflammatory_respons0.86485665
119MP0001697_abnormal_embryo_size0.86371360
120MP0003724_increased_susceptibility_to0.85454394
121MP0000313_abnormal_cell_death0.85184332
122MP0001672_abnormal_embryogenesis/_devel0.84279696
123MP0005380_embryogenesis_phenotype0.84279696
124MP0002148_abnormal_hypersensitivity_rea0.83950009
125MP0001243_abnormal_dermal_layer0.83756904
126MP0003984_embryonic_growth_retardation0.82989304
127MP0001663_abnormal_digestive_system0.82536219
128MP0002080_prenatal_lethality0.82261306
129MP0002088_abnormal_embryonic_growth/wei0.82117270
130MP0003329_amyloid_beta_deposits0.77344079
131MP0002138_abnormal_hepatobiliary_system0.75972752
132MP0000249_abnormal_blood_vessel0.72771155
133MP0000343_altered_response_to0.71057342
134MP0008004_abnormal_stomach_pH0.71024151
135MP0008874_decreased_physiological_sensi0.69470325
136MP0005666_abnormal_adipose_tissue0.68607932
137MP0009763_increased_sensitivity_to0.66938489
138MP0000609_abnormal_liver_physiology0.66745017
139MP0000015_abnormal_ear_pigmentation0.63922962
140MP0002006_tumorigenesis0.63417112
141MP0009115_abnormal_fat_cell0.63310772
142MP0004185_abnormal_adipocyte_glucose0.63248210
143MP0005075_abnormal_melanosome_morpholog0.63234582
144MP0005365_abnormal_bile_salt0.62666909

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macrophages (HP:0004311)4.40601060
2Recurrent bacterial skin infections (HP:0005406)4.32816653
3Retrobulbar optic neuritis (HP:0100654)3.80451829
4Optic neuritis (HP:0100653)3.80451829
5Cervical subluxation (HP:0003308)3.77885744
6Recurrent gram-negative bacterial infections (HP:0005420)3.71336485
7Epiphyseal dysplasia (HP:0002656)3.51422052
8Recurrent fungal infections (HP:0002841)3.29689241
9Mediastinal lymphadenopathy (HP:0100721)3.27088687
10Spontaneous hematomas (HP:0007420)3.25201042
11Chronic obstructive pulmonary disease (HP:0006510)3.22543935
12Obstructive lung disease (HP:0006536)3.22543935
13Small epiphyses (HP:0010585)3.22309383
14Gastrointestinal infarctions (HP:0005244)3.21476881
15Increased IgE level (HP:0003212)3.15152846
16Meningitis (HP:0001287)3.12579545
17Abnormal delayed hypersensitivity skin test (HP:0002963)3.11042689
18Gingivitis (HP:0000230)3.10823101
19Protrusio acetabuli (HP:0003179)2.98802552
20Irregular epiphyses (HP:0010582)2.96978630
21Increased cerebral lipofuscin (HP:0011813)2.93286523
22Ankle contracture (HP:0006466)2.93070535
23Colitis (HP:0002583)2.91693647
24Recurrent skin infections (HP:0001581)2.90595159
25Stomatitis (HP:0010280)2.87778188
26Vasculitis (HP:0002633)2.86613160
27Gastrointestinal inflammation (HP:0004386)2.84517139
28Urticaria (HP:0001025)2.81883125
29Inflammation of the large intestine (HP:0002037)2.81084375
30Keratoconjunctivitis sicca (HP:0001097)2.76955996
31Mesomelia (HP:0003027)2.74802394
32Abnormality of liposaccharide metabolism (HP:0010968)2.74130034
33Abnormality of glycosphingolipid metabolism (HP:0004343)2.74130034
34Abnormality of glycolipid metabolism (HP:0010969)2.74130034
35Chronic mucocutaneous candidiasis (HP:0002728)2.72686809
36Recurrent cutaneous fungal infections (HP:0011370)2.72686809
37Prolonged bleeding time (HP:0003010)2.68844265
38Hypoplastic ischia (HP:0003175)2.68133471
39Amyloidosis (HP:0011034)2.58812845
40Increased neuronal autofluorescent lipopigment (HP:0002074)2.58543497
41Dysostosis multiplex (HP:0000943)2.54068183
42Abnormality of the distal phalanges of the toes (HP:0010182)2.50898992
43Encephalitis (HP:0002383)2.49945184
44Loss of speech (HP:0002371)2.49608586
45Gingival bleeding (HP:0000225)2.48770290
46Chest pain (HP:0100749)2.48537237
47Reticulocytopenia (HP:0001896)2.48055568
48Thrombocytosis (HP:0001894)2.47853773
49Keratoconjunctivitis (HP:0001096)2.46113798
50Pulmonary infiltrates (HP:0002113)2.45690996
51Hemoptysis (HP:0002105)2.45220004
52Flat capital femoral epiphysis (HP:0003370)2.44839110
53Epistaxis (HP:0000421)2.43011056
54Interstitial pulmonary disease (HP:0006530)2.41719461
55Delayed epiphyseal ossification (HP:0002663)2.40002165
56Arterial thrombosis (HP:0004420)2.39251102
57Ulnar bowing (HP:0003031)2.37941354
58Obstructive sleep apnea (HP:0002870)2.36427667
59Hypochromic anemia (HP:0001931)2.34201104
60Systemic lupus erythematosus (HP:0002725)2.32452376
61Flat acetabular roof (HP:0003180)2.31119288
62Selective tooth agenesis (HP:0001592)2.29436999
63Shallow orbits (HP:0000586)2.27697761
64Metaphyseal cupping (HP:0003021)2.27218869
65Pulmonary embolism (HP:0002204)2.26925259
66Genu recurvatum (HP:0002816)2.25894995
67Radial bowing (HP:0002986)2.25336645
68Purpura (HP:0000979)2.25257722
69Premature rupture of membranes (HP:0001788)2.22830459
70Slow saccadic eye movements (HP:0000514)2.21695162
71Abnormality of polysaccharide metabolism (HP:0011012)2.20650906
72Abnormality of glycosaminoglycan metabolism (HP:0004371)2.20650906
73Abnormality of mucopolysaccharide metabolism (HP:0011020)2.20650906
74Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.19899444
75Osteomyelitis (HP:0002754)2.17866186
76Abnormality of T cell number (HP:0011839)2.17540411
77Petechiae (HP:0000967)2.17234776
78Neonatal short-limb short stature (HP:0008921)2.16837814
79Myositis (HP:0100614)2.16626581
80Mucopolysacchariduria (HP:0008155)2.14793748
81Urinary glycosaminoglycan excretion (HP:0003541)2.14793748
82Cupped ribs (HP:0000887)2.14605661
83Segmental peripheral demyelination/remyelination (HP:0003481)2.14081543
84Abnormality of the ischium (HP:0003174)2.12934486
85T lymphocytopenia (HP:0005403)2.11989621
86Platyspondyly (HP:0000926)2.11882071
87Mild short stature (HP:0003502)2.10216832
88Autoimmune thrombocytopenia (HP:0001973)2.09657184
89Granulocytopenia (HP:0001913)2.07914031
90Increased IgM level (HP:0003496)2.06412013
91Rhizomelia (HP:0008905)2.06387594
92Anorexia (HP:0002039)2.06366634
93Short 4th metacarpal (HP:0010044)2.05018761
94Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.05018761
95Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.03212849
96Episodic fever (HP:0001954)2.00880501
97Malnutrition (HP:0004395)2.00671231
98Hemorrhage of the eye (HP:0011885)2.00652684
99Dislocated radial head (HP:0003083)2.00260470
100Broad thumb (HP:0011304)1.99716722
101Flattened epiphyses (HP:0003071)1.99688900
102Abnormal ossification of hand bones (HP:0005921)1.98473425
103Aortic aneurysm (HP:0004942)1.97981084
104Cellulitis (HP:0100658)1.97492238
105Leukocytosis (HP:0001974)1.97127105
106Spinal cord compression (HP:0002176)1.95472106
107Abnormality of the radial head (HP:0003995)1.94701544
108Broad face (HP:0000283)1.94255645
10911 pairs of ribs (HP:0000878)1.93854942
110Hypergammaglobulinemia (HP:0010702)1.92076220
111Eczematoid dermatitis (HP:0000976)1.90279091
112Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.90228448
113Absent epiphyses (HP:0010577)1.90228448
114Autoimmune hemolytic anemia (HP:0001890)1.88762508
115Bowed forearm bones (HP:0003956)1.87597336
116Bowing of the arm (HP:0006488)1.87597336
117Agammaglobulinemia (HP:0004432)1.87021438
118Recurrent abscess formation (HP:0002722)1.86841500
119Abnormality of carpal bone ossification (HP:0006257)1.86613033
120Polycythemia (HP:0001901)1.84732382
121Sepsis (HP:0100806)1.84183450
122Abnormal foot bone ossification (HP:0010675)1.84020423
123Nasal polyposis (HP:0100582)1.83866613
124Abnormality of T cells (HP:0002843)1.83558108
125Restrictive lung disease (HP:0002091)1.83398776
126Abnormality of the 4th metacarpal (HP:0010012)1.83216778
127Broad phalanx (HP:0006009)1.82994919
128Recurrent bronchitis (HP:0002837)1.82538111
129Cerebral aneurysm (HP:0004944)1.82444104
130Increased density of long bones (HP:0006392)1.81695741
131Lumbar hyperlordosis (HP:0002938)1.81651511
132IgM deficiency (HP:0002850)1.80430408
133Carpal bone hypoplasia (HP:0001498)1.80358357
134Osteoarthritis (HP:0002758)1.80221646
135Acne (HP:0001061)1.79810415
136Broad long bones (HP:0005622)1.79721034
137Premature loss of primary teeth (HP:0006323)1.79069472
138Glossoptosis (HP:0000162)1.78802373
139Broad phalanges of the hand (HP:0009768)1.78793353
140Genu varum (HP:0002970)1.78565437
141Hand muscle atrophy (HP:0009130)1.78106572
142Abnormality of the pleura (HP:0002103)1.78032757
143Abnormality of the acetabulum (HP:0003170)1.77932103
144Increased serum ferritin (HP:0003281)1.77398519
145Limited elbow extension (HP:0001377)1.77287119
146Broad metatarsal (HP:0001783)1.76720762
147Abnormality of cells of the erythroid lineage (HP:0012130)1.76611984
148Hypochromic microcytic anemia (HP:0004840)1.75785927
149Gangrene (HP:0100758)1.75276867
150Pustule (HP:0200039)1.75081844
151Exostoses (HP:0100777)1.75012645
152Polygenic inheritance (HP:0010982)1.74977434
153Abnormality of the nasal mucosa (HP:0000433)1.74379324
154Flared metaphyses (HP:0003015)1.73777839
155Thin bony cortex (HP:0002753)1.73706555
156Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.73652810
157Gastrointestinal stroma tumor (HP:0100723)1.72900559
158Vertebral clefting (HP:0008428)1.72503830
159Abnormality of the endocardium (HP:0004306)1.72386660
160Peritonitis (HP:0002586)1.72318441
161Ependymoma (HP:0002888)1.72177795
162Thoracolumbar scoliosis (HP:0002944)1.71030215
163Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.69805678
164Vertebral hypoplasia (HP:0008417)1.69805678
165High pitched voice (HP:0001620)1.69258820
166Abnormality of the calcaneus (HP:0008364)1.68660799
167Abnormal number of erythroid precursors (HP:0012131)1.68596679
168Orchitis (HP:0100796)1.66131447
169Dilatation of the ascending aorta (HP:0005111)1.66116988
170Broad palm (HP:0001169)1.66101368
171Hypoplasia of the odontoid process (HP:0003311)1.65706472
172Atrophic scars (HP:0001075)1.64727912
173Abnormal vertebral ossification (HP:0100569)1.64716837
174Abnormal hand bone ossification (HP:0010660)1.62729074
175Elevated erythrocyte sedimentation rate (HP:0003565)1.61838072
176Deviation of the thumb (HP:0009603)1.61557406
177Recurrent viral infections (HP:0004429)1.61216208
178Wrist flexion contracture (HP:0001239)1.60723408
179Broad finger (HP:0001500)1.60463200
180Short 5th finger (HP:0009237)1.59710768
181Severe short stature (HP:0003510)1.58951394
182Periodontitis (HP:0000704)1.58837633
183Abnormality of the odontoid process (HP:0003310)1.58633993
184Persistence of primary teeth (HP:0006335)1.58581897
185Abnormality of the fingertips (HP:0001211)1.57215172
186Stillbirth (HP:0003826)1.57056401
187Coxa vara (HP:0002812)1.55342966

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.59603281
2EEF2K3.55788522
3DDR23.23004272
4PRPF4B2.92271584
5MAP3K102.70650372
6MAP4K12.59653161
7TRIB32.40619560
8PKN22.30941497
9ERN12.21505939
10TNK21.95129769
11TAOK11.95048686
12BLK1.92886958
13NEK21.90619787
14MAP3K131.84479421
15CDK121.80364554
16BUB11.77980486
17FES1.71474227
18PAK41.68215587
19SMG11.66509669
20ZAP701.65382473
21TGFBR11.63592476
22STK101.62901894
23RPS6KB21.61402672
24LRRK21.55303824
25PASK1.54244560
26TESK11.53850883
27SIK11.52699678
28RPS6KA41.51487134
29PTK61.49126350
30TTN1.48994334
31MAP3K111.46294127
32KIT1.42941742
33WEE11.41672802
34CSF1R1.37020015
35MARK21.36687328
36SIK31.34928847
37FLT31.32714969
38NME21.32275907
39MAP3K11.30875035
40FGR1.28941243
41BTK1.22334938
42PRKD21.21851457
43ACVR1B1.18881587
44MAPKAPK31.17409246
45CDC42BPA1.16835794
46PIM11.16384709
47TAOK21.14925378
48TBK11.13498671
49KSR21.12878878
50TYK21.09802359
51EPHB11.09469202
52EIF2AK11.07622312
53TLK11.07418443
54CDC71.06437719
55JAK21.04766582
56MAP3K81.00199450
57PDPK10.98736819
58CDK70.98291510
59JAK30.97987113
60GRK60.96150901
61SIK20.94939330
62CHUK0.94229919
63DYRK30.93725573
64TESK20.93163473
65BRSK20.93153578
66TTK0.93093881
67MAP3K60.92560239
68FGFR40.92444774
69SCYL20.91742279
70MAP3K30.91623085
71MATK0.89290893
72PDK10.89241789
73CAMKK10.88595869
74MAP2K30.88542352
75PDGFRA0.88317131
76ATR0.87180018
77PIM20.85860459
78TGFBR20.83219592
79IRAK20.82883507
80HCK0.81629744
81HIPK20.80192758
82PLK10.79944309
83IRAK10.79615836
84IKBKB0.79518597
85EPHA20.79348547
86AURKB0.79327936
87MAPK150.77961049
88SGK30.76390061
89MTOR0.76322939
90TXK0.75728510
91CDK40.75513326
92STK40.75421227
93RIPK10.75256200
94JAK10.73379114
95IRAK40.72692169
96TRPM70.72247406
97CSK0.71398321
98BMX0.71245751
99STK380.70453148
100PAK20.70117536
101STK30.68502873
102PIK3CG0.68376777
103CAMK1D0.67369624
104IRAK30.67166481
105IKBKE0.66438453
106DYRK1B0.66343869
107RET0.66013086
108MAP3K70.65583889
109MAP3K20.64076367
110SYK0.63777466
111CDK60.63659972
112MAP3K140.63397031
113MAPK120.62968255
114MAP2K20.62632359
115EPHA30.62245972
116LYN0.61914128
117ICK0.60848106
118NEK90.59825729
119MELK0.59553401
120RPS6KA20.58468805
121RPS6KC10.56570826
122RPS6KL10.56570826
123PTK2B0.56550999
124YES10.55889436
125RPS6KA60.55771315
126LCK0.55146314
127MAPK70.54946447
128FYN0.52943454
129ITK0.51439079
130ALK0.50875590
131MARK30.50180642
132CHEK10.50052448
133CLK10.49210830
134EIF2AK20.49099083
135FGFR30.48465479
136MAPKAPK20.48087836
137TSSK60.47976827
138RPS6KA10.47785593
139TEC0.47712259
140PDGFRB0.47629346
141TAOK30.47347157
142MAPK110.43913874
143MAP2K60.42743271
144BMPR20.42742874
145NEK60.37908252

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.76669974
2Mismatch repair_Homo sapiens_hsa034302.26150561
3Staphylococcus aureus infection_Homo sapiens_hsa051502.23825135
4Ribosome_Homo sapiens_hsa030102.17517946
5Base excision repair_Homo sapiens_hsa034102.10480031
6Cell cycle_Homo sapiens_hsa041101.84049562
7Spliceosome_Homo sapiens_hsa030401.77281054
8RNA transport_Homo sapiens_hsa030131.76313165
9One carbon pool by folate_Homo sapiens_hsa006701.70565148
10Graft-versus-host disease_Homo sapiens_hsa053321.67283427
11Leishmaniasis_Homo sapiens_hsa051401.66097906
12Allograft rejection_Homo sapiens_hsa053301.62465014
13Antigen processing and presentation_Homo sapiens_hsa046121.56606954
14Legionellosis_Homo sapiens_hsa051341.55156060
15Autoimmune thyroid disease_Homo sapiens_hsa053201.52297392
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.50163836
17Primary immunodeficiency_Homo sapiens_hsa053401.47580294
18Homologous recombination_Homo sapiens_hsa034401.46138630
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.44734831
20B cell receptor signaling pathway_Homo sapiens_hsa046621.42149475
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.38705520
22Chemokine signaling pathway_Homo sapiens_hsa040621.37978254
23ECM-receptor interaction_Homo sapiens_hsa045121.36746862
24Chronic myeloid leukemia_Homo sapiens_hsa052201.36431960
25Apoptosis_Homo sapiens_hsa042101.34422327
26Measles_Homo sapiens_hsa051621.33981055
27p53 signaling pathway_Homo sapiens_hsa041151.33384350
28Viral carcinogenesis_Homo sapiens_hsa052031.33076901
29Small cell lung cancer_Homo sapiens_hsa052221.30905829
30Herpes simplex infection_Homo sapiens_hsa051681.25224899
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23494954
32Acute myeloid leukemia_Homo sapiens_hsa052211.23245833
33Osteoclast differentiation_Homo sapiens_hsa043801.22120227
34Nucleotide excision repair_Homo sapiens_hsa034201.22014999
35VEGF signaling pathway_Homo sapiens_hsa043701.20808680
36Malaria_Homo sapiens_hsa051441.18420534
37Hepatitis B_Homo sapiens_hsa051611.17554502
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.17257786
39Other glycan degradation_Homo sapiens_hsa005111.16792974
40HTLV-I infection_Homo sapiens_hsa051661.16530765
41Phagosome_Homo sapiens_hsa041451.13433071
42Type I diabetes mellitus_Homo sapiens_hsa049401.11873054
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11237407
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.10938172
45Hematopoietic cell lineage_Homo sapiens_hsa046401.10755516
46Toxoplasmosis_Homo sapiens_hsa051451.10197283
47Protein digestion and absorption_Homo sapiens_hsa049741.08299392
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07382605
49Fanconi anemia pathway_Homo sapiens_hsa034601.04830410
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04011212
51Focal adhesion_Homo sapiens_hsa045101.03201579
52MicroRNAs in cancer_Homo sapiens_hsa052061.01650978
53Selenocompound metabolism_Homo sapiens_hsa004501.01493070
54Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00641252
55Epstein-Barr virus infection_Homo sapiens_hsa051691.00156797
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99751121
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.99508523
58Influenza A_Homo sapiens_hsa051640.99059928
59Proteoglycans in cancer_Homo sapiens_hsa052050.98717381
60Shigellosis_Homo sapiens_hsa051310.97200097
61Renal cell carcinoma_Homo sapiens_hsa052110.97039121
62Thyroid cancer_Homo sapiens_hsa052160.96804057
63TNF signaling pathway_Homo sapiens_hsa046680.96555115
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.96320168
65Systemic lupus erythematosus_Homo sapiens_hsa053220.94582456
66Endometrial cancer_Homo sapiens_hsa052130.94356869
67Notch signaling pathway_Homo sapiens_hsa043300.94291391
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93866261
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.93342084
70Prolactin signaling pathway_Homo sapiens_hsa049170.93111577
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92927275
72Pancreatic cancer_Homo sapiens_hsa052120.91769120
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91331348
74Endocytosis_Homo sapiens_hsa041440.91326238
75Toll-like receptor signaling pathway_Homo sapiens_hsa046200.90582842
76mTOR signaling pathway_Homo sapiens_hsa041500.89717815
77Pyrimidine metabolism_Homo sapiens_hsa002400.89230229
78Non-small cell lung cancer_Homo sapiens_hsa052230.88201309
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87920314
80Salmonella infection_Homo sapiens_hsa051320.86993085
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85317899
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.84991666
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84299661
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84195681
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.84188415
86Bladder cancer_Homo sapiens_hsa052190.84082049
87African trypanosomiasis_Homo sapiens_hsa051430.84010317
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83839034
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.82752530
90mRNA surveillance pathway_Homo sapiens_hsa030150.82415873
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82359379
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.81067323
93Choline metabolism in cancer_Homo sapiens_hsa052310.80745102
94Asthma_Homo sapiens_hsa053100.79987276
95GnRH signaling pathway_Homo sapiens_hsa049120.79167187
96Inositol phosphate metabolism_Homo sapiens_hsa005620.78429138
97Prostate cancer_Homo sapiens_hsa052150.78184612
98T cell receptor signaling pathway_Homo sapiens_hsa046600.77080998
99Adherens junction_Homo sapiens_hsa045200.74659658
100Tuberculosis_Homo sapiens_hsa051520.74522164
101Colorectal cancer_Homo sapiens_hsa052100.73714266
102Rheumatoid arthritis_Homo sapiens_hsa053230.73602198
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73558417
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73394884
105Non-homologous end-joining_Homo sapiens_hsa034500.72813191
106Platelet activation_Homo sapiens_hsa046110.71578708
107Pentose phosphate pathway_Homo sapiens_hsa000300.70140004
108Lysosome_Homo sapiens_hsa041420.69591593
109Viral myocarditis_Homo sapiens_hsa054160.68978618
110FoxO signaling pathway_Homo sapiens_hsa040680.68453423
111HIF-1 signaling pathway_Homo sapiens_hsa040660.68030144
112Hepatitis C_Homo sapiens_hsa051600.67820363
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67490744
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66234061
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65881255
116ErbB signaling pathway_Homo sapiens_hsa040120.65718389
117Amoebiasis_Homo sapiens_hsa051460.64104689
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63886588
119Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63419250
120RNA degradation_Homo sapiens_hsa030180.63265858
121Insulin signaling pathway_Homo sapiens_hsa049100.63250805
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60874431
123* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60298477
124TGF-beta signaling pathway_Homo sapiens_hsa043500.60214445
125Proteasome_Homo sapiens_hsa030500.59039494
126Pathways in cancer_Homo sapiens_hsa052000.58878312
127Estrogen signaling pathway_Homo sapiens_hsa049150.58544063
128Basal cell carcinoma_Homo sapiens_hsa052170.58532918
129Pertussis_Homo sapiens_hsa051330.57042506
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56730609
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.56644908
132Insulin resistance_Homo sapiens_hsa049310.55293180
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55092229
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.54319609
135Fructose and mannose metabolism_Homo sapiens_hsa000510.54280796
136Glioma_Homo sapiens_hsa052140.53340550
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53227689
138Prion diseases_Homo sapiens_hsa050200.51503263
139Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46343589
140Dorso-ventral axis formation_Homo sapiens_hsa043200.45980646
141Rap1 signaling pathway_Homo sapiens_hsa040150.45645466

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