XAB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.41423867
2maturation of SSU-rRNA (GO:0030490)5.18345322
3negative regulation of erythrocyte differentiation (GO:0045647)5.11274834
4viral transcription (GO:0019083)4.89716531
5translational termination (GO:0006415)4.75922174
6DNA strand elongation involved in DNA replication (GO:0006271)4.61272058
7DNA unwinding involved in DNA replication (GO:0006268)4.59409096
8DNA strand elongation (GO:0022616)4.39213133
9DNA deamination (GO:0045006)4.37499378
10ribosomal small subunit biogenesis (GO:0042274)4.36610070
11ribosomal large subunit biogenesis (GO:0042273)4.34566579
12translational elongation (GO:0006414)4.32427035
13telomere maintenance via semi-conservative replication (GO:0032201)4.28876840
14formation of translation preinitiation complex (GO:0001731)4.21755833
15DNA replication initiation (GO:0006270)4.15889244
16translational initiation (GO:0006413)4.08793275
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.06351617
18SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.99886032
19ribonucleoprotein complex biogenesis (GO:0022613)3.90875887
20cotranslational protein targeting to membrane (GO:0006613)3.90039104
21nucleobase biosynthetic process (GO:0046112)3.89676418
22protein targeting to ER (GO:0045047)3.88593070
23positive regulation of gamma-delta T cell activation (GO:0046645)3.80971020
24IMP biosynthetic process (GO:0006188)3.78068657
25cellular protein complex disassembly (GO:0043624)3.75614662
26viral life cycle (GO:0019058)3.74989740
27telomere maintenance via recombination (GO:0000722)3.71307787
28NIK/NF-kappaB signaling (GO:0038061)3.71090084
29DNA replication checkpoint (GO:0000076)3.70867807
30establishment of protein localization to endoplasmic reticulum (GO:0072599)3.70739622
31mannose metabolic process (GO:0006013)3.67224416
32ribosome biogenesis (GO:0042254)3.65887426
333-UTR-mediated mRNA stabilization (GO:0070935)3.64943119
34protein localization to endoplasmic reticulum (GO:0070972)3.64612002
35folic acid-containing compound biosynthetic process (GO:0009396)3.56835289
36COPI coating of Golgi vesicle (GO:0048205)3.54904287
37Golgi transport vesicle coating (GO:0048200)3.54904287
38protein complex disassembly (GO:0043241)3.52011305
39response to muramyl dipeptide (GO:0032495)3.49717015
40mitotic recombination (GO:0006312)3.49590320
41telomere maintenance via telomere lengthening (GO:0010833)3.49576809
42antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.47008404
43purine nucleobase biosynthetic process (GO:0009113)3.46181895
44negative regulation of cell killing (GO:0031342)3.45168600
45negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.45168600
46rRNA processing (GO:0006364)3.41625327
47DNA replication-dependent nucleosome assembly (GO:0006335)3.38867957
48DNA replication-dependent nucleosome organization (GO:0034723)3.38867957
49protein localization to kinetochore (GO:0034501)3.37897201
50mitotic nuclear envelope disassembly (GO:0007077)3.37223242
51thymic T cell selection (GO:0045061)3.36737914
52positive thymic T cell selection (GO:0045059)3.31487888
53rRNA metabolic process (GO:0016072)3.31028857
54nucleotide-excision repair, DNA gap filling (GO:0006297)3.30824575
55macromolecular complex disassembly (GO:0032984)3.29518597
56IMP metabolic process (GO:0046040)3.28165629
57antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.27864193
58nuclear-transcribed mRNA catabolic process (GO:0000956)3.26380317
59antigen processing and presentation of endogenous antigen (GO:0019883)3.21295553
60negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.20975053
61modulation by symbiont of host cellular process (GO:0044068)3.14941282
62apoptotic process involved in morphogenesis (GO:0060561)3.12991142
63spliceosomal snRNP assembly (GO:0000387)3.12842552
64mRNA catabolic process (GO:0006402)3.10937802
65modulation by virus of host process (GO:0019054)3.10789300
66positive regulation by symbiont of host defense response (GO:0052509)3.10557091
67modulation by symbiont of host defense response (GO:0052031)3.10557091
68modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.10557091
69modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.10557091
70positive regulation by organism of defense response of other organism involved in symbiotic interact3.10557091
71modulation by symbiont of host immune response (GO:0052553)3.10557091
72regulation of translational fidelity (GO:0006450)3.10448780
73negative regulation of RNA splicing (GO:0033119)3.09288423
74embryonic process involved in female pregnancy (GO:0060136)3.09091111
75regulation of type I interferon-mediated signaling pathway (GO:0060338)3.09058275
76nuclear envelope disassembly (GO:0051081)3.08292812
77membrane disassembly (GO:0030397)3.08292812
78RNA catabolic process (GO:0006401)3.07827900
79response to laminar fluid shear stress (GO:0034616)3.07068905
80positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.05464535
81protein localization to endosome (GO:0036010)3.05252897
82DNA duplex unwinding (GO:0032508)3.05085468
83pseudouridine synthesis (GO:0001522)3.04330642
84response to peptidoglycan (GO:0032494)3.03459724
85DNA geometric change (GO:0032392)3.02341522
86ribosome assembly (GO:0042255)3.02087000
87regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.00520643
88regulation of gamma-delta T cell activation (GO:0046643)2.99936279
89germinal center formation (GO:0002467)2.98652757
90viral mRNA export from host cell nucleus (GO:0046784)2.97931219
91somatic hypermutation of immunoglobulin genes (GO:0016446)2.96580281
92somatic diversification of immune receptors via somatic mutation (GO:0002566)2.96580281
93nuclear pore organization (GO:0006999)2.95393362
94translation (GO:0006412)2.94514872
95activation of MAPKKK activity (GO:0000185)2.93895391
96protein localization to chromosome, centromeric region (GO:0071459)2.93851863
97regulation of histone H3-K9 methylation (GO:0051570)2.91450066
98regulation of gamma-delta T cell differentiation (GO:0045586)2.90064373
99* mRNA splicing, via spliceosome (GO:0000398)2.89620404
100* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.89620404
101telomere organization (GO:0032200)2.88773579
102telomere maintenance (GO:0000723)2.87511176
103regulation of histone H3-K27 methylation (GO:0061085)2.87237354
104spliceosomal tri-snRNP complex assembly (GO:0000244)2.86646628
105* RNA splicing, via transesterification reactions (GO:0000375)2.86615411
106activation of Rac GTPase activity (GO:0032863)2.85812899
107peptidyl-arginine omega-N-methylation (GO:0035247)2.84098018
108leukocyte aggregation (GO:0070486)2.83497165
109detection of bacterium (GO:0016045)2.83431581
110translesion synthesis (GO:0019985)2.82426014
111negative regulation of cell size (GO:0045792)2.81221054
112mitotic metaphase plate congression (GO:0007080)2.79764657
113negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.78502146
114regulation of NFAT protein import into nucleus (GO:0051532)2.78478243
115antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.78409821
116termination of RNA polymerase II transcription (GO:0006369)2.78128574
117cellular component biogenesis (GO:0044085)2.77733577
118T cell selection (GO:0045058)2.77258093
119adherens junction assembly (GO:0034333)2.76625190
120cell-substrate adherens junction assembly (GO:0007045)2.75562973
121focal adhesion assembly (GO:0048041)2.75562973
122postreplication repair (GO:0006301)2.75121066
123regulation of early endosome to late endosome transport (GO:2000641)2.74844182
124negative regulation of histone methylation (GO:0031061)2.73070752
125detection of other organism (GO:0098543)2.72422097
126barbed-end actin filament capping (GO:0051016)2.70718398
127negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.70221262
128intracellular estrogen receptor signaling pathway (GO:0030520)2.69075735
129pinocytosis (GO:0006907)2.69023915
130retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.69019479
131negative regulation of mRNA processing (GO:0050686)2.68988906
132mitotic sister chromatid segregation (GO:0000070)2.68927930
133spliceosomal complex assembly (GO:0000245)2.68492746
134positive regulation of Cdc42 GTPase activity (GO:0043089)2.68388651
135base-excision repair (GO:0006284)2.67761099
136DNA replication-independent nucleosome organization (GO:0034724)2.66959509
137DNA replication-independent nucleosome assembly (GO:0006336)2.66959509
138proteasome assembly (GO:0043248)2.66606856
139negative thymic T cell selection (GO:0045060)2.66484826
140chromatin remodeling at centromere (GO:0031055)2.65742491
141* transcription-coupled nucleotide-excision repair (GO:0006283)2.65026731
142CENP-A containing nucleosome assembly (GO:0034080)2.64371476
143ncRNA 3-end processing (GO:0043628)2.63988232
144nuclear pore complex assembly (GO:0051292)2.63216660
145snRNA processing (GO:0016180)2.63011079
146epithelial cell differentiation involved in prostate gland development (GO:0060742)2.63007401
147negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.62994296
148negative regulation of viral release from host cell (GO:1902187)2.62670053
149mitotic chromosome condensation (GO:0007076)2.62109580
150anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.61738940
151intra-S DNA damage checkpoint (GO:0031573)2.61738212
152pentose-phosphate shunt (GO:0006098)2.61268058
153regulation of defense response to virus by virus (GO:0050690)2.60631965
154DNA topological change (GO:0006265)2.60606754
155regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.60601938
156ncRNA processing (GO:0034470)2.60589295
157DNA-templated transcription, termination (GO:0006353)2.59832946
158dosage compensation (GO:0007549)2.59805595
159regulation of chromatin binding (GO:0035561)2.58558974
160snRNA metabolic process (GO:0016073)2.58378633
161regulation of helicase activity (GO:0051095)2.58000785
162macrophage activation involved in immune response (GO:0002281)2.56656433
163regulation of mammary gland epithelial cell proliferation (GO:0033599)2.55041061
164histone H3-K36 demethylation (GO:0070544)2.54506395
165cellular response to interleukin-4 (GO:0071353)2.54423493
166tolerance induction (GO:0002507)2.52990800
167positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.52239512
168positive T cell selection (GO:0043368)2.50291883
169positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.50290687
170RNA stabilization (GO:0043489)2.49289385
171mRNA stabilization (GO:0048255)2.49289385
172cellular response to virus (GO:0098586)2.48412509
173myeloid dendritic cell differentiation (GO:0043011)2.46404946
174histone H4 deacetylation (GO:0070933)2.45857077
175lipopolysaccharide-mediated signaling pathway (GO:0031663)2.44955071
176regulation of leukocyte degranulation (GO:0043300)2.43721820
177regulation of nucleobase-containing compound transport (GO:0032239)2.43233088
178stress fiber assembly (GO:0043149)2.42453930
179negative T cell selection (GO:0043383)2.41909061
180proline biosynthetic process (GO:0006561)2.41794887
181positive regulation of histone deacetylation (GO:0031065)2.40666096
182negative regulation of toll-like receptor signaling pathway (GO:0034122)2.40581420
183regulation of necroptotic process (GO:0060544)2.38516050
184signal complex assembly (GO:0007172)2.37415286
185negative regulation of necroptotic process (GO:0060546)2.36211126
186positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.36190017
187positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.35293640
188regulation of ARF GTPase activity (GO:0032312)2.34829022
189type I interferon signaling pathway (GO:0060337)2.34582930
190cellular response to type I interferon (GO:0071357)2.34582930
191regulation of extracellular matrix disassembly (GO:0010715)2.34451860
192regulation of glucose import in response to insulin stimulus (GO:2001273)2.33681713
193response to type I interferon (GO:0034340)2.33159727
194B cell receptor signaling pathway (GO:0050853)2.33102527
195activation of JUN kinase activity (GO:0007257)2.33026848
196regulation of ARF protein signal transduction (GO:0032012)2.32953782
197response to interleukin-4 (GO:0070670)2.32605053
198regulation of T-helper 2 cell differentiation (GO:0045628)2.32328011
199negative regulation of myotube differentiation (GO:0010832)2.30851905

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.42850026
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.90961640
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.66666963
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.16625328
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.92304634
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.85644315
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.65309833
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.64795628
9* EST1_17652178_ChIP-ChIP_JURKAT_Human2.59161603
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.58815204
11* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.57798135
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.52484645
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.50186324
14* LXR_22292898_ChIP-Seq_THP-1_Human2.48718585
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.48559267
16KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.46623285
17KDM2B_26808549_Chip-Seq_SUP-B15_Human2.41935394
18MYC_22102868_ChIP-Seq_BL_Human2.40372470
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.34807028
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.33533751
21XRN2_22483619_ChIP-Seq_HELA_Human2.32251990
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.32122373
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.28780806
24* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.27317719
25KDM2B_26808549_Chip-Seq_DND41_Human2.18561628
26CREB1_15753290_ChIP-ChIP_HEK293T_Human2.16203235
27* VDR_23849224_ChIP-Seq_CD4+_Human2.11781755
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08853803
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.07779205
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.04700410
31ELF1_17652178_ChIP-ChIP_JURKAT_Human2.00451050
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.95973359
33CIITA_25753668_ChIP-Seq_RAJI_Human1.95738173
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.92616782
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.91770542
36* FOXP3_21729870_ChIP-Seq_TREG_Human1.91508104
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.90593445
38RACK7_27058665_Chip-Seq_MCF-7_Human1.89090998
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.89040164
40* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.85912548
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.83506156
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81623315
43VDR_21846776_ChIP-Seq_THP-1_Human1.79710546
44DCP1A_22483619_ChIP-Seq_HELA_Human1.79558114
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.78714299
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.75919897
47GABP_19822575_ChIP-Seq_HepG2_Human1.74788790
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70295621
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70176684
50TTF2_22483619_ChIP-Seq_HELA_Human1.67379106
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.65812137
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64406293
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62628028
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61576381
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59816656
56SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.56180869
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.56111344
58KDM2B_26808549_Chip-Seq_JURKAT_Human1.51826520
59BRD4_27068464_Chip-Seq_AML-cells_Mouse1.51767974
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.51100604
61STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50223565
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49544569
63KDM2B_26808549_Chip-Seq_K562_Human1.49249053
64PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48084663
65CTCF_27219007_Chip-Seq_ERYTHROID_Human1.47569557
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.47471065
67KDM5A_27292631_Chip-Seq_BREAST_Human1.47096640
68ZNF263_19887448_ChIP-Seq_K562_Human1.46439036
69P68_20966046_ChIP-Seq_HELA_Human1.45785601
70* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45430938
71* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.44804300
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.44686039
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43510200
74NCOR1_26117541_ChIP-Seq_K562_Human1.42812349
75NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42562835
76SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.42077279
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.41076659
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39988431
79ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38844977
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38558738
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37928249
82SA1_27219007_Chip-Seq_ERYTHROID_Human1.37597389
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.35465281
84AR_21909140_ChIP-Seq_LNCAP_Human1.34741949
85E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.34577791
86TET1_21451524_ChIP-Seq_MESCs_Mouse1.34446769
87SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33990898
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33968366
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.32434023
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.32412959
91KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31254728
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30167593
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29971965
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29401691
95IRF8_22096565_ChIP-ChIP_GC-B_Human1.28706481
96TFEB_21752829_ChIP-Seq_HELA_Human1.28464934
97* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27839568
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26784522
99ELF1_20517297_ChIP-Seq_JURKAT_Human1.26148472
100UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24737981
101CLOCK_20551151_ChIP-Seq_293T_Human1.23995756
102RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.23372773
103P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22461545
104SPI1_23547873_ChIP-Seq_NB4_Human1.21497897
105SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20085987
106* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19747670
107CREB1_26743006_Chip-Seq_LNCaP_Human1.19429866
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19101229
109STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18848912
110* SMC4_20622854_ChIP-Seq_HELA_Human1.18651933
111SRF_21415370_ChIP-Seq_HL-1_Mouse1.17591066
112* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17216228
113KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16808434
114GATA1_19941827_ChIP-Seq_MEL_Mouse1.15749475
115* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15093389
116DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15001731
117SPI1_23127762_ChIP-Seq_K562_Human1.14254149
118ATF3_27146783_Chip-Seq_COLON_Human1.13895927
119ELK1_19687146_ChIP-ChIP_HELA_Human1.13726027
120MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13139678
121CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12760729
122PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12408428
123BCOR_27268052_Chip-Seq_Bcells_Human1.11899260
124MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.09975217
125UTX_26944678_Chip-Seq_JUKART_Human1.09321623
126HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08891434
127RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08783229
128MAF_26560356_Chip-Seq_TH1_Human1.08019286
129IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07735754
130KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07599411
131STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.07589294
132E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07435699
133TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07429209
134TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07196694
135RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06760566
136TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06620849
137SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05150272
138* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04761312
139GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04454259
140CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04435203
141CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01999557
142BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01587772
143TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01532311
144TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01190493
145NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99989370
146GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99745842
147KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99643558
148FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.99619395
149* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97739225
150SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96481166
151MYB_26560356_Chip-Seq_TH1_Human0.94766486
152PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93987406
153SCL_19346495_ChIP-Seq_HPC-7_Human0.93443425
154POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93243993
155* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91485904
156MAF_26560356_Chip-Seq_TH2_Human0.91459078
157MYB_26560356_Chip-Seq_TH2_Human0.91216185
158RUNX1_22412390_ChIP-Seq_EML_Mouse0.90385340
159TCF7_22412390_ChIP-Seq_EML_Mouse0.87043385
160GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86931946
161PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85980643
162MYB_21317192_ChIP-Seq_ERMYB_Mouse0.84432919
163VDR_24763502_ChIP-Seq_THP-1_Human0.83153985
164STAT4_19710469_ChIP-ChIP_TH1__Mouse0.82417812

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.56575848
2MP0010094_abnormal_chromosome_stability4.06405270
3MP0003111_abnormal_nucleus_morphology3.85244049
4MP0004957_abnormal_blastocyst_morpholog3.81468292
5MP0003077_abnormal_cell_cycle3.47303071
6MP0005451_abnormal_body_composition3.34087044
7MP0008057_abnormal_DNA_replication3.33101240
8MP0003705_abnormal_hypodermis_morpholog3.16698035
9MP0002396_abnormal_hematopoietic_system3.03482274
10MP0005058_abnormal_lysosome_morphology2.93585880
11MP0008058_abnormal_DNA_repair2.80096659
12MP0008260_abnormal_autophagy2.69997227
13MP0008007_abnormal_cellular_replicative2.69569035
14MP0003300_gastrointestinal_ulcer2.49605494
15MP0003763_abnormal_thymus_physiology2.40867484
16MP0003172_abnormal_lysosome_physiology2.26043003
17MP0009840_abnormal_foam_cell2.22959354
18MP0010352_gastrointestinal_tract_polyps2.11909545
19* MP0001730_embryonic_growth_arrest2.08042743
20MP0000350_abnormal_cell_proliferation2.06516617
21MP0008932_abnormal_embryonic_tissue2.04144897
22MP0008877_abnormal_DNA_methylation2.01418262
23MP0003786_premature_aging1.97013872
24MP0000490_abnormal_crypts_of1.93964989
25MP0001545_abnormal_hematopoietic_system1.87652252
26MP0005397_hematopoietic_system_phenotyp1.87652252
27MP0002398_abnormal_bone_marrow1.87427431
28MP0004185_abnormal_adipocyte_glucose1.83389916
29MP0003191_abnormal_cellular_cholesterol1.82521635
30MP0004808_abnormal_hematopoietic_stem1.80767581
31MP0009333_abnormal_splenocyte_physiolog1.80368589
32MP0000703_abnormal_thymus_morphology1.75941188
33MP0003453_abnormal_keratinocyte_physiol1.75491544
34MP0002877_abnormal_melanocyte_morpholog1.68098405
35MP0002419_abnormal_innate_immunity1.66498804
36MP0002722_abnormal_immune_system1.65256981
37MP0000689_abnormal_spleen_morphology1.64153455
38MP0000685_abnormal_immune_system1.62528466
39MP0002019_abnormal_tumor_incidence1.61776830
40MP0004510_myositis1.61763435
41MP0001800_abnormal_humoral_immune1.56084737
42MP0003091_abnormal_cell_migration1.55213194
43MP0001697_abnormal_embryo_size1.53940906
44MP0000313_abnormal_cell_death1.53578752
45MP0009278_abnormal_bone_marrow1.53191977
46* MP0002080_prenatal_lethality1.52373989
47MP0004858_abnormal_nervous_system1.51083145
48MP0010307_abnormal_tumor_latency1.47632340
49MP0005075_abnormal_melanosome_morpholog1.47629141
50MP0001835_abnormal_antigen_presentation1.47168446
51MP0005076_abnormal_cell_differentiation1.46013953
52MP0001672_abnormal_embryogenesis/_devel1.45888679
53MP0005380_embryogenesis_phenotype1.45888679
54MP0001348_abnormal_lacrimal_gland1.45273914
55MP0002429_abnormal_blood_cell1.45188814
56MP0005671_abnormal_response_to1.44350367
57MP0000716_abnormal_immune_system1.43522163
58MP0010234_abnormal_vibrissa_follicle1.36828514
59MP0005666_abnormal_adipose_tissue1.34785773
60MP0002254_reproductive_system_inflammat1.34631072
61MP0002420_abnormal_adaptive_immunity1.33301896
62MP0003984_embryonic_growth_retardation1.32178343
63MP0001819_abnormal_immune_cell1.31023013
64MP0002085_abnormal_embryonic_tissue1.29664396
65MP0002088_abnormal_embryonic_growth/wei1.28196287
66MP0001533_abnormal_skeleton_physiology1.27855573
67MP0003806_abnormal_nucleotide_metabolis1.27761672
68MP0002452_abnormal_antigen_presenting1.27662593
69MP0000465_gastrointestinal_hemorrhage1.26720677
70MP0005174_abnormal_tail_pigmentation1.26408202
71MP0002084_abnormal_developmental_patter1.24513894
72MP0003123_paternal_imprinting1.23732162
73MP0002723_abnormal_immune_serum1.21298001
74MP0000858_altered_metastatic_potential1.21141664
75MP0002086_abnormal_extraembryonic_tissu1.20906020
76MP0002998_abnormal_bone_remodeling1.17902646
77MP0003866_abnormal_defecation1.17682770
78MP0005375_adipose_tissue_phenotype1.16485289
79MP0001873_stomach_inflammation1.14468962
80MP0004197_abnormal_fetal_growth/weight/1.13263225
81MP0002166_altered_tumor_susceptibility1.12532101
82MP0002796_impaired_skin_barrier1.12123368
83MP0003724_increased_susceptibility_to1.11353518
84MP0000358_abnormal_cell_content/1.11220488
85MP0000678_abnormal_parathyroid_gland1.10811970
86MP0003329_amyloid_beta_deposits1.08120921
87MP0003567_abnormal_fetal_cardiomyocyte1.06649929
88MP0002405_respiratory_system_inflammati1.03759361
89MP0002095_abnormal_skin_pigmentation1.03269043
90MP0004233_abnormal_muscle_weight1.03204146
91MP0002210_abnormal_sex_determination1.03009790
92MP0002089_abnormal_postnatal_growth/wei1.02766158
93MP0001145_abnormal_male_reproductive1.00498921
94MP0003656_abnormal_erythrocyte_physiolo1.00245619
95MP0010155_abnormal_intestine_physiology1.00136353
96MP0001293_anophthalmia0.99839501
97MP0005000_abnormal_immune_tolerance0.99135424
98MP0008438_abnormal_cutaneous_collagen0.97664913
99MP0000003_abnormal_adipose_tissue0.97633928
100MP0000604_amyloidosis0.97477187
101MP0004381_abnormal_hair_follicle0.97145499
102MP0002653_abnormal_ependyma_morphology0.96915438
103MP0005025_abnormal_response_to0.95985937
104MP0003828_pulmonary_edema0.95677175
105MP0002006_tumorigenesis0.94251819
106MP0000733_abnormal_muscle_development0.93747905
107MP0003075_altered_response_to0.93378465
108MP0001851_eye_inflammation0.93275544
109MP0003221_abnormal_cardiomyocyte_apopto0.92220893
110MP0005387_immune_system_phenotype0.90697766
111MP0001790_abnormal_immune_system0.90697766
112MP0005310_abnormal_salivary_gland0.89002045
113MP0009931_abnormal_skin_appearance0.88934190
114MP0000747_muscle_weakness0.87540361
115MP0002933_joint_inflammation0.86953738
116MP0001929_abnormal_gametogenesis0.85867981
117MP0006082_CNS_inflammation0.85733001
118MP0000751_myopathy0.85639625
119MP0000477_abnormal_intestine_morphology0.84978311
120MP0004264_abnormal_extraembryonic_tissu0.83449564
121MP0005023_abnormal_wound_healing0.83043667
122MP0005384_cellular_phenotype0.82980933
123MP0003448_altered_tumor_morphology0.82454910
124MP0003279_aneurysm0.81548709
125MP0001853_heart_inflammation0.80836929
126MP0002060_abnormal_skin_morphology0.80359473
127MP0005621_abnormal_cell_physiology0.79414189
128MP0003315_abnormal_perineum_morphology0.78035613
129MP0002132_abnormal_respiratory_system0.78013512
130MP0004947_skin_inflammation0.77963570
131MP0005464_abnormal_platelet_physiology0.77881148
132MP0008469_abnormal_protein_level0.75999102
133MP0003566_abnormal_cell_adhesion0.75509587
134MP0000653_abnormal_sex_gland0.74658832
135MP0000015_abnormal_ear_pigmentation0.74581606
136MP0000371_diluted_coat_color0.72968457
137MP0003718_maternal_effect0.72537037
138MP0009785_altered_susceptibility_to0.71986513
139MP0005501_abnormal_skin_physiology0.71509128
140MP0003436_decreased_susceptibility_to0.71497693
141MP0003119_abnormal_digestive_system0.67836166
142MP0003303_peritoneal_inflammation0.67817741
143MP0008995_early_reproductive_senescence0.67605140
144MP0002148_abnormal_hypersensitivity_rea0.65767816
145MP0006054_spinal_hemorrhage0.63703727
146MP0001845_abnormal_inflammatory_respons0.63376260
147MP0002075_abnormal_coat/hair_pigmentati0.60960833
148MP0001915_intracranial_hemorrhage0.59615652
149MP0001849_ear_inflammation0.59606338

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.94483018
2Abnormality of cells of the erythroid lineage (HP:0012130)4.83430970
3Abnormal number of erythroid precursors (HP:0012131)4.55792055
4Birth length less than 3rd percentile (HP:0003561)3.94594822
5Eczematoid dermatitis (HP:0000976)3.65431938
6IgM deficiency (HP:0002850)3.57399738
7Aplastic anemia (HP:0001915)3.52195242
8Oral leukoplakia (HP:0002745)3.50900792
9Thrombocytosis (HP:0001894)3.50810054
10Pallor (HP:0000980)3.38915780
11Macrocytic anemia (HP:0001972)3.31853604
12Selective tooth agenesis (HP:0001592)3.30624982
13Ependymoma (HP:0002888)3.17290330
14Breast hypoplasia (HP:0003187)3.14551028
15Absent thumb (HP:0009777)3.10290782
16Basal cell carcinoma (HP:0002671)3.09558649
1711 pairs of ribs (HP:0000878)2.92058739
18Obstructive sleep apnea (HP:0002870)2.90893490
19Patellar aplasia (HP:0006443)2.87872673
20Rough bone trabeculation (HP:0100670)2.85532532
21Carpal bone hypoplasia (HP:0001498)2.84717058
22Myelodysplasia (HP:0002863)2.84677497
23Colon cancer (HP:0003003)2.82390340
24Cellulitis (HP:0100658)2.81839567
25Increased connective tissue (HP:0009025)2.78971685
26Medulloblastoma (HP:0002885)2.74624255
27Hyperacusis (HP:0010780)2.71576525
28Aplasia/Hypoplasia of the patella (HP:0006498)2.69344841
29Cerebral hypomyelination (HP:0006808)2.69189608
30Lymphoma (HP:0002665)2.67659449
31Distal lower limb amyotrophy (HP:0008944)2.65930509
32Abnormality of the anterior horn cell (HP:0006802)2.64879535
33Degeneration of anterior horn cells (HP:0002398)2.64879535
34Broad face (HP:0000283)2.64199598
35Agnosia (HP:0010524)2.60605583
36Increased IgE level (HP:0003212)2.60194065
37Neoplasm of the pancreas (HP:0002894)2.59366175
38Abnormality of macrophages (HP:0004311)2.57893516
39Centrally nucleated skeletal muscle fibers (HP:0003687)2.57821787
40Amaurosis fugax (HP:0100576)2.57436573
41Cholecystitis (HP:0001082)2.56969758
42Abnormal gallbladder physiology (HP:0012438)2.56969758
43Chronic otitis media (HP:0000389)2.56691053
44Premature graying of hair (HP:0002216)2.54280820
45Abnormality of the preputium (HP:0100587)2.52865757
46Recurrent bronchitis (HP:0002837)2.51062804
47Colitis (HP:0002583)2.48502158
48Bone marrow hypocellularity (HP:0005528)2.43812774
49Cerebral aneurysm (HP:0004944)2.40450968
50Long palpebral fissure (HP:0000637)2.39617633
51Vertebral compression fractures (HP:0002953)2.36269460
52Cellular immunodeficiency (HP:0005374)2.35169951
53Recurrent abscess formation (HP:0002722)2.33216632
54Poikiloderma (HP:0001029)2.29950464
55Abnormality of the ileum (HP:0001549)2.28429474
56Gastrointestinal inflammation (HP:0004386)2.27957274
57Recurrent bacterial skin infections (HP:0005406)2.25818368
58Trismus (HP:0000211)2.25699312
59Gastrointestinal stroma tumor (HP:0100723)2.24751264
60Abnormality of chromosome stability (HP:0003220)2.24489882
61Chromsome breakage (HP:0040012)2.24382611
62Meckel diverticulum (HP:0002245)2.23423739
63Abnormal number of incisors (HP:0011064)2.23135853
64Panhypogammaglobulinemia (HP:0003139)2.20779524
65IgG deficiency (HP:0004315)2.20593431
66Distal lower limb muscle weakness (HP:0009053)2.20505110
67Microretrognathia (HP:0000308)2.20387028
68Distal upper limb amyotrophy (HP:0007149)2.19471401
69Upper limb amyotrophy (HP:0009129)2.19471401
70Pancytopenia (HP:0001876)2.19347045
71Achilles tendon contracture (HP:0001771)2.18164033
72Abnormality of T cells (HP:0002843)2.17811604
73Disproportionate tall stature (HP:0001519)2.17655027
74Aplasia/Hypoplasia of the sacrum (HP:0008517)2.16315937
75Abnormality of T cell physiology (HP:0011840)2.15692874
76Squamous cell carcinoma (HP:0002860)2.15475268
77Absent radius (HP:0003974)2.14828481
78Abnormality of the fingertips (HP:0001211)2.13551917
79Horseshoe kidney (HP:0000085)2.11866147
80Prominent nose (HP:0000448)2.09763082
81Dysostosis multiplex (HP:0000943)2.09497718
82Abnormality of the thoracic spine (HP:0100711)2.08869037
83Neoplasm of the oral cavity (HP:0100649)2.07578155
84Segmental peripheral demyelination/remyelination (HP:0003481)2.06433376
85Mediastinal lymphadenopathy (HP:0100721)2.05406777
86Abnormality of B cell number (HP:0010975)2.02418560
87B lymphocytopenia (HP:0010976)2.02418560
88Hemorrhage of the eye (HP:0011885)2.02350052
89Emphysema (HP:0002097)2.02294152
90Missing ribs (HP:0000921)2.01467998
91Chromosomal breakage induced by crosslinking agents (HP:0003221)2.01307421
92Ulnar bowing (HP:0003031)2.01296966
93Recurrent viral infections (HP:0004429)2.00909228
94Loss of speech (HP:0002371)2.00121082
95Slow saccadic eye movements (HP:0000514)1.99451798
96Abnormality of cells of the lymphoid lineage (HP:0012140)1.99310631
97Tracheoesophageal fistula (HP:0002575)1.99248905
98Thin bony cortex (HP:0002753)1.98347045
99Chronic obstructive pulmonary disease (HP:0006510)1.98077825
100Obstructive lung disease (HP:0006536)1.98077825
101Polygenic inheritance (HP:0010982)1.97886988
102Neuronal loss in central nervous system (HP:0002529)1.97409677
103Combined immunodeficiency (HP:0005387)1.97201958
104Aplasia/Hypoplasia of the uvula (HP:0010293)1.97196477
105Inflammation of the large intestine (HP:0002037)1.96638611
106Reticulocytosis (HP:0001923)1.96009544
107Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.95839365
108Premature ovarian failure (HP:0008209)1.94936763
109Absent forearm bone (HP:0003953)1.94371636
110Aplasia involving forearm bones (HP:0009822)1.94371636
111Rhabdomyosarcoma (HP:0002859)1.93587068
112Protrusio acetabuli (HP:0003179)1.93450542
113Abnormality of reticulocytes (HP:0004312)1.93348097
114Asplenia (HP:0001746)1.92543828
115Interstitial pulmonary disease (HP:0006530)1.91296044
116Gingivitis (HP:0000230)1.91286842
117Hypertensive crisis (HP:0100735)1.90816041
118Elevated erythrocyte sedimentation rate (HP:0003565)1.90742095
119Abnormality of the Achilles tendon (HP:0005109)1.90327037
120T lymphocytopenia (HP:0005403)1.90254678
121Petechiae (HP:0000967)1.89994895
122Thoracic kyphosis (HP:0002942)1.89937723
123Ectopic kidney (HP:0000086)1.89875918
124Proximal placement of thumb (HP:0009623)1.88778302
125Lymphopenia (HP:0001888)1.87894403
126Hypoplasia of the radius (HP:0002984)1.87797179
127Biconcave vertebral bodies (HP:0004586)1.87510176
128Abnormal trabecular bone morphology (HP:0100671)1.86770838
129Duodenal stenosis (HP:0100867)1.86336484
130Small intestinal stenosis (HP:0012848)1.86336484
131Increased variability in muscle fiber diameter (HP:0003557)1.86243110
132Leukopenia (HP:0001882)1.86180917
133Stenosis of the external auditory canal (HP:0000402)1.85526752
134Difficulty climbing stairs (HP:0003551)1.85455278
135Meningitis (HP:0001287)1.85170133
136Deep palmar crease (HP:0006191)1.85066239
137Severe combined immunodeficiency (HP:0004430)1.84802110
138Stridor (HP:0010307)1.84450564
139Myopathic facies (HP:0002058)1.84447833
140Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.84031620
141Easy fatigability (HP:0003388)1.83977857
142Insomnia (HP:0100785)1.83789934
143Triphalangeal thumb (HP:0001199)1.83751432
144Premature rupture of membranes (HP:0001788)1.82831756
145Supranuclear gaze palsy (HP:0000605)1.82745854
146Flat acetabular roof (HP:0003180)1.81610023
147Myositis (HP:0100614)1.81602403
148Atresia of the external auditory canal (HP:0000413)1.79768015
149Dilatation of the ascending aorta (HP:0005111)1.79210052
150Increased cerebral lipofuscin (HP:0011813)1.77896505
151Aneurysm (HP:0002617)1.77861486
152Abnormality of skeletal muscle fiber size (HP:0012084)1.77312876
153Abnormality of DNA repair (HP:0003254)1.77077829
154Multiple enchondromatosis (HP:0005701)1.76915252
155Axonal loss (HP:0003447)1.76890542
156Lower limb amyotrophy (HP:0007210)1.76461718
157Recurrent fungal infections (HP:0002841)1.76122024
158Metaphyseal cupping (HP:0003021)1.76103441
159Aplasia/Hypoplasia of the thymus (HP:0010515)1.75880886
160Peripheral hypomyelination (HP:0007182)1.75867310
161Abnormality of glycosphingolipid metabolism (HP:0004343)1.75522603
162Abnormality of glycolipid metabolism (HP:0010969)1.75522603
163Abnormality of liposaccharide metabolism (HP:0010968)1.75522603
164Hypoplasia of the thymus (HP:0000778)1.75274858
165Hypoplasia of the capital femoral epiphysis (HP:0003090)1.74964270
166Cerebral inclusion bodies (HP:0100314)1.74782262
167Cafe-au-lait spot (HP:0000957)1.74661628
168Severe visual impairment (HP:0001141)1.74517384
169Impulsivity (HP:0100710)1.73684444
170Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.73634562
171Decreased activity of mitochondrial respiratory chain (HP:0008972)1.73634562
172Cervical subluxation (HP:0003308)1.72559316
173Slender long bone (HP:0003100)1.72521575
174Spontaneous hematomas (HP:0007420)1.72139974
175Progressive external ophthalmoplegia (HP:0000590)1.71848761
176Sloping forehead (HP:0000340)1.71768438
177Pustule (HP:0200039)1.71730608
178Nasal polyposis (HP:0100582)1.71360776
179Fatigue (HP:0012378)1.70065868
180Ankyloglossia (HP:0010296)1.68902833
181Gastrointestinal dysmotility (HP:0002579)1.68784979
182Gastrointestinal infarctions (HP:0005244)1.68419687
183Dislocated radial head (HP:0003083)1.65160694
184Ragged-red muscle fibers (HP:0003200)1.64285316
185Upper motor neuron abnormality (HP:0002127)1.64218210
186Premature skin wrinkling (HP:0100678)1.63193177
187Dysmetric saccades (HP:0000641)1.62701024
188Mitral regurgitation (HP:0001653)1.62190953
189Recurrent gram-negative bacterial infections (HP:0005420)1.61864519
190Hypertriglyceridemia (HP:0002155)1.61859231
191Pointed chin (HP:0000307)1.60885169
192Osteomyelitis (HP:0002754)1.60873452
193Verrucae (HP:0200043)1.60605372
194Papilloma (HP:0012740)1.60605372
195J-shaped sella turcica (HP:0002680)1.59481049
196Abnormality of oral frenula (HP:0000190)1.59397015
197Increased serum ferritin (HP:0003281)1.59022265
198Spinal cord lesions (HP:0100561)1.57716879

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.15483085
2PRPF4B3.88566064
3SMG13.52304596
4WEE13.48071859
5ERN13.08013568
6CDC73.07076844
7TLK12.93539641
8MAP4K12.89307512
9TSSK62.82067603
10EEF2K2.70299999
11SIK12.61616619
12NEK22.44193056
13MAP3K102.22590461
14EIF2AK12.22264268
15RPS6KB22.19055578
16STK162.04350897
17SRPK12.01813396
18IRAK32.00662253
19ACVR1B1.97796612
20TESK21.93741731
21NME21.92919820
22RIPK41.89593692
23CDK121.87552502
24STK101.86875110
25PASK1.86565163
26FGFR41.75726201
27TGFBR11.73159910
28RIPK11.72457431
29TTK1.63617255
30MAP3K131.58930470
31CDK71.57094526
32BRSK21.56290356
33ATR1.52309886
34SIK31.51904301
35LRRK21.47077889
36EPHA21.45717038
37MAP3K141.44757336
38PLK11.43522596
39EPHB11.43089590
40TTN1.41168745
41DYRK31.38820997
42NEK11.38206565
43VRK11.37670059
44CDK41.36844832
45FLT31.34649684
46MAP3K81.33111954
47IRAK41.32456683
48EIF2AK31.32444054
49ZAP701.31958725
50SIK21.30602815
51PKN21.29884332
52TBK11.26560056
53MARK21.24722903
54MAP3K31.22818082
55AURKB1.19058961
56KSR21.18291227
57BLK1.17946954
58BTK1.17303268
59PAK41.15100291
60BRD41.15053888
61TAOK11.12274999
62SCYL21.11432641
63PRKD21.06790108
64RPS6KA41.06172069
65MAP3K11.05701540
66TNK21.05081190
67PIM21.04729451
68MKNK11.03184213
69PIM10.99551362
70CHEK10.96338053
71CCNB10.94614933
72CDC42BPA0.94329635
73GRK60.91902856
74CHEK20.91225809
75PTK60.90692645
76KDR0.89044515
77STK40.87097939
78ARAF0.86363277
79PDGFRA0.86077792
80TAOK20.84897521
81MAP3K110.83410098
82AURKA0.83310696
83IRAK20.82376661
84BMX0.79534045
85HIPK20.79204310
86MAP3K60.78106046
87PDPK10.77450483
88CSF1R0.77046385
89BRSK10.76254973
90CDK20.75404792
91JAK30.73778058
92CLK10.71471392
93HCK0.70001734
94TXK0.69948824
95BCKDK0.68988216
96FES0.68767032
97MAPKAPK30.68751631
98PLK30.68112645
99PRKD30.66860029
100TYK20.66470161
101KIT0.65370860
102ATM0.64811075
103MAP3K70.64524255
104ALK0.63781877
105RPS6KA50.63615775
106RPS6KL10.62920951
107TRIB30.61457898
108MAPK120.60860406
109CSNK2A20.60209661
110PAK10.59541603
111RPS6KA20.58750061
112PLK40.58592353
113IKBKE0.58283006
114CAMKK10.57717999
115LCK0.56943766
116PDK10.55320274
117MAP2K20.54940182
118TEC0.54258990
119MKNK20.53649169
120MTOR0.51692620
121JAK10.50851144
122IKBKB0.50644471
123CSNK2A10.50594205
124PRKCI0.49910375
125MAPK110.49116178
126MST1R0.48552580
127ITK0.48345362
128MARK30.48279252
129CDK190.47679559
130FGFR30.46734078
131LYN0.45289368
132CDK90.45066527
133ICK0.44970677
134FGR0.44875498
135TYRO30.44635840
136RET0.44596717
137CDK60.44337667
138SYK0.42343998
139MAPK70.41936305
140CDK10.41728480
141PTK20.40426001
142MAP2K30.40402326
143CAMK1D0.40008998
144MOS0.39862882
145JAK20.39251949
146CSK0.36908802
147MAPKAPK20.36020035
148BRAF0.35908135
149TESK10.35790749
150ILK0.35098161
151RAF10.35028886
152MATK0.34105651
153RPS6KA10.33910098
154PAK20.33497335
155MST40.32859710
156ZAK0.32082963
157MELK0.30746691
158RPS6KA60.29921573
159RPS6KC10.29907385

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.81163972
2Mismatch repair_Homo sapiens_hsa034304.15111877
3Ribosome_Homo sapiens_hsa030103.95201559
4* Spliceosome_Homo sapiens_hsa030403.34839123
5Base excision repair_Homo sapiens_hsa034103.16617871
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.16322531
7RNA polymerase_Homo sapiens_hsa030202.92453417
8Homologous recombination_Homo sapiens_hsa034402.87013509
9RNA transport_Homo sapiens_hsa030132.78372438
10Proteasome_Homo sapiens_hsa030502.69112361
11Nucleotide excision repair_Homo sapiens_hsa034202.67084379
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.64415983
13One carbon pool by folate_Homo sapiens_hsa006702.42709783
14Cell cycle_Homo sapiens_hsa041102.33789772
15Pyrimidine metabolism_Homo sapiens_hsa002402.19597529
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.14017371
17Fanconi anemia pathway_Homo sapiens_hsa034601.90679450
18Non-homologous end-joining_Homo sapiens_hsa034501.85521549
19Primary immunodeficiency_Homo sapiens_hsa053401.76718447
20mRNA surveillance pathway_Homo sapiens_hsa030151.67753584
21VEGF signaling pathway_Homo sapiens_hsa043701.62256525
22Basal transcription factors_Homo sapiens_hsa030221.59443931
23RNA degradation_Homo sapiens_hsa030181.55758549
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.55471980
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.54503763
26p53 signaling pathway_Homo sapiens_hsa041151.41139925
27Antigen processing and presentation_Homo sapiens_hsa046121.38169045
28Epstein-Barr virus infection_Homo sapiens_hsa051691.32658026
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32348941
30Neurotrophin signaling pathway_Homo sapiens_hsa047221.29998836
31Prion diseases_Homo sapiens_hsa050201.26454596
32Endometrial cancer_Homo sapiens_hsa052131.25813797
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.22298866
34TNF signaling pathway_Homo sapiens_hsa046681.20612267
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.18105587
36Renal cell carcinoma_Homo sapiens_hsa052111.18031775
37Hepatitis C_Homo sapiens_hsa051601.17325929
38Systemic lupus erythematosus_Homo sapiens_hsa053221.16379894
39Herpes simplex infection_Homo sapiens_hsa051681.15007336
40Viral carcinogenesis_Homo sapiens_hsa052031.11691581
41Purine metabolism_Homo sapiens_hsa002301.10409250
42Tuberculosis_Homo sapiens_hsa051521.07164700
43Pentose phosphate pathway_Homo sapiens_hsa000301.06289154
44Glioma_Homo sapiens_hsa052141.05858850
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.02531131
46Sulfur relay system_Homo sapiens_hsa041221.02455555
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02212229
48Insulin signaling pathway_Homo sapiens_hsa049101.01947912
49ErbB signaling pathway_Homo sapiens_hsa040120.98941087
50Prolactin signaling pathway_Homo sapiens_hsa049170.96826052
51Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95123240
52Folate biosynthesis_Homo sapiens_hsa007900.91989115
53Prostate cancer_Homo sapiens_hsa052150.91882002
54Selenocompound metabolism_Homo sapiens_hsa004500.89902963
55Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89192479
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.87707361
57HTLV-I infection_Homo sapiens_hsa051660.86297273
58Inositol phosphate metabolism_Homo sapiens_hsa005620.85106678
59Lysosome_Homo sapiens_hsa041420.83956949
60Biosynthesis of amino acids_Homo sapiens_hsa012300.83799805
61Salmonella infection_Homo sapiens_hsa051320.83601571
62GnRH signaling pathway_Homo sapiens_hsa049120.83268434
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.83143649
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.83008836
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.82251122
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81353423
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80922998
68Malaria_Homo sapiens_hsa051440.80707495
69Choline metabolism in cancer_Homo sapiens_hsa052310.80482305
70Chemokine signaling pathway_Homo sapiens_hsa040620.79922285
71Endocytosis_Homo sapiens_hsa041440.79637960
72B cell receptor signaling pathway_Homo sapiens_hsa046620.78723417
73Measles_Homo sapiens_hsa051620.78293882
74Acute myeloid leukemia_Homo sapiens_hsa052210.77225022
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76675040
76Autoimmune thyroid disease_Homo sapiens_hsa053200.75571293
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74297773
78Staphylococcus aureus infection_Homo sapiens_hsa051500.70961918
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70611988
80Graft-versus-host disease_Homo sapiens_hsa053320.70462600
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70209746
82Legionellosis_Homo sapiens_hsa051340.69906607
83Amoebiasis_Homo sapiens_hsa051460.68749110
84Proteoglycans in cancer_Homo sapiens_hsa052050.67659788
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67408585
86Insulin resistance_Homo sapiens_hsa049310.66992327
87AMPK signaling pathway_Homo sapiens_hsa041520.66138566
88Thyroid cancer_Homo sapiens_hsa052160.65022563
89Estrogen signaling pathway_Homo sapiens_hsa049150.65004674
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64840408
91Apoptosis_Homo sapiens_hsa042100.64650921
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.64429611
93Focal adhesion_Homo sapiens_hsa045100.63410257
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63315772
95Notch signaling pathway_Homo sapiens_hsa043300.63079306
96Hematopoietic cell lineage_Homo sapiens_hsa046400.62934323
97Shigellosis_Homo sapiens_hsa051310.62920131
98Protein export_Homo sapiens_hsa030600.62615394
99FoxO signaling pathway_Homo sapiens_hsa040680.62247141
100Pertussis_Homo sapiens_hsa051330.61872576
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61597978
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61523586
103N-Glycan biosynthesis_Homo sapiens_hsa005100.58268770
104Oocyte meiosis_Homo sapiens_hsa041140.57999084
105Platelet activation_Homo sapiens_hsa046110.57216463
106T cell receptor signaling pathway_Homo sapiens_hsa046600.55250106
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52805954
108Alcoholism_Homo sapiens_hsa050340.51950981
109Chronic myeloid leukemia_Homo sapiens_hsa052200.51797803
110Small cell lung cancer_Homo sapiens_hsa052220.50619809
111Hepatitis B_Homo sapiens_hsa051610.49822461
112Fructose and mannose metabolism_Homo sapiens_hsa000510.43586993
113Colorectal cancer_Homo sapiens_hsa052100.42408049
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42198549
115Drug metabolism - other enzymes_Homo sapiens_hsa009830.42041964
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41985367
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.41970429
118Other glycan degradation_Homo sapiens_hsa005110.41812794
119Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40758093
120MicroRNAs in cancer_Homo sapiens_hsa052060.39670172
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.39424575
122Influenza A_Homo sapiens_hsa051640.39094980
123Leishmaniasis_Homo sapiens_hsa051400.38471854
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36736576
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36420430
126Bladder cancer_Homo sapiens_hsa052190.34228554
127Viral myocarditis_Homo sapiens_hsa054160.34035189
128Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.33229157
129Carbon metabolism_Homo sapiens_hsa012000.31950121
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.30194217
131Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29756096
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.29444346
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29194407
134mTOR signaling pathway_Homo sapiens_hsa041500.28774357
135Galactose metabolism_Homo sapiens_hsa000520.27535770
136Vitamin B6 metabolism_Homo sapiens_hsa007500.23900353
137HIF-1 signaling pathway_Homo sapiens_hsa040660.23259518
138Pathways in cancer_Homo sapiens_hsa052000.23159243
139Allograft rejection_Homo sapiens_hsa053300.21225433
140Non-small cell lung cancer_Homo sapiens_hsa052230.21181602
1412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.20280401
142Pancreatic cancer_Homo sapiens_hsa052120.19771444
143Toxoplasmosis_Homo sapiens_hsa051450.19687400
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18208005
145Osteoclast differentiation_Homo sapiens_hsa043800.17487544
146Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17376169
147Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.16061671
148Basal cell carcinoma_Homo sapiens_hsa052170.15535966
149Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.15199655
150Glutathione metabolism_Homo sapiens_hsa004800.14919991

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