XAF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.43849584
2central nervous system myelination (GO:0022010)7.43849584
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.31596603
4protein neddylation (GO:0045116)6.05216172
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.93744118
6energy coupled proton transport, down electrochemical gradient (GO:0015985)5.83466909
7ATP synthesis coupled proton transport (GO:0015986)5.83466909
8* response to type I interferon (GO:0034340)5.46197064
9* cellular response to type I interferon (GO:0071357)5.43388457
10* type I interferon signaling pathway (GO:0060337)5.43388457
11positive regulation of gamma-delta T cell activation (GO:0046645)5.29099076
12fatty acid elongation (GO:0030497)4.95304148
13respiratory electron transport chain (GO:0022904)4.87361571
14long-chain fatty acid biosynthetic process (GO:0042759)4.83670689
15electron transport chain (GO:0022900)4.74036010
16regulation of B cell receptor signaling pathway (GO:0050855)4.73727102
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.73053247
18negative regulation of cell killing (GO:0031342)4.73053247
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.68377152
20ribosomal small subunit biogenesis (GO:0042274)4.65988053
21establishment of protein localization to mitochondrial membrane (GO:0090151)4.58743407
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.57773709
23antigen processing and presentation of endogenous antigen (GO:0019883)4.50978159
24dopamine biosynthetic process (GO:0042416)4.46218995
25response to interferon-alpha (GO:0035455)4.44011889
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.43832934
27negative regulation of viral genome replication (GO:0045071)4.14582943
28regulation of gamma-delta T cell activation (GO:0046643)4.12134317
29negative regulation of neurotransmitter transport (GO:0051589)4.09716920
30interferon-gamma-mediated signaling pathway (GO:0060333)4.07321424
31cholesterol biosynthetic process (GO:0006695)4.06115395
32regulation of MHC class I biosynthetic process (GO:0045343)4.05226277
33myelination (GO:0042552)4.03780786
34glycerophospholipid catabolic process (GO:0046475)4.02316290
35axon ensheathment (GO:0008366)4.00858819
36ensheathment of neurons (GO:0007272)4.00858819
37dopamine transport (GO:0015872)3.96154551
38neuron cell-cell adhesion (GO:0007158)3.92333350
39positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.78581380
40chaperone-mediated protein transport (GO:0072321)3.75547597
41positive regulation by symbiont of host defense response (GO:0052509)3.71328120
42modulation by symbiont of host defense response (GO:0052031)3.71328120
43modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.71328120
44modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.71328120
45positive regulation by organism of defense response of other organism involved in symbiotic interact3.71328120
46modulation by symbiont of host immune response (GO:0052553)3.71328120
47substantia nigra development (GO:0021762)3.67903234
48macrophage activation involved in immune response (GO:0002281)3.65889637
49negative regulation of T cell mediated immunity (GO:0002710)3.64354399
50positive regulation of interferon-alpha production (GO:0032727)3.63026904
51immunoglobulin mediated immune response (GO:0016064)3.62265894
52negative regulation of interleukin-12 production (GO:0032695)3.61583932
53regulation of gamma-delta T cell differentiation (GO:0045586)3.61406452
54regulation of interferon-alpha production (GO:0032647)3.61041782
55regulation of catecholamine metabolic process (GO:0042069)3.58580892
56regulation of dopamine metabolic process (GO:0042053)3.58580892
57neuron remodeling (GO:0016322)3.56373119
58detection of other organism (GO:0098543)3.55848722
59GPI anchor biosynthetic process (GO:0006506)3.55371380
60sterol biosynthetic process (GO:0016126)3.52049917
61isoprenoid biosynthetic process (GO:0008299)3.51751303
62detection of bacterium (GO:0016045)3.47426499
63negative regulation of lymphocyte mediated immunity (GO:0002707)3.46632771
64establishment of viral latency (GO:0019043)3.46629817
65regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.45958668
66cellular response to exogenous dsRNA (GO:0071360)3.41690226
67activated T cell proliferation (GO:0050798)3.40611973
68regulation of collateral sprouting (GO:0048670)3.37912799
69T cell migration (GO:0072678)3.36096435
70protein-cofactor linkage (GO:0018065)3.35960333
71cellular response to interferon-alpha (GO:0035457)3.34296805
72termination of RNA polymerase III transcription (GO:0006386)3.32745620
73transcription elongation from RNA polymerase III promoter (GO:0006385)3.32745620
74presynaptic membrane organization (GO:0097090)3.30278821
75negative T cell selection (GO:0043383)3.28973237
76defense response to virus (GO:0051607)3.27964321
77negative regulation of protein localization to cell surface (GO:2000009)3.27651498
78negative thymic T cell selection (GO:0045060)3.27435361
79regulation of dendritic cell antigen processing and presentation (GO:0002604)3.27364523
80GPI anchor metabolic process (GO:0006505)3.27217577
81GTP biosynthetic process (GO:0006183)3.25145623
82establishment of integrated proviral latency (GO:0075713)3.25120936
83detection of molecule of bacterial origin (GO:0032490)3.23169088
84microglial cell activation (GO:0001774)3.22048273
85preassembly of GPI anchor in ER membrane (GO:0016254)3.21766683
86positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.20849450
87detection of external biotic stimulus (GO:0098581)3.20812525
88response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.20746654
89response to host immune response (GO:0052572)3.20746654
90response to interleukin-15 (GO:0070672)3.17939096
91interferon-gamma production (GO:0032609)3.17696801
92limb bud formation (GO:0060174)3.16505374
93presynaptic membrane assembly (GO:0097105)3.15368402
94cellular response to interleukin-15 (GO:0071350)3.14622811
95defense response to protozoan (GO:0042832)3.13564838
96response to redox state (GO:0051775)3.12941913
97proteasome assembly (GO:0043248)3.12799296
98B cell receptor signaling pathway (GO:0050853)3.11067959
99hydrogen ion transmembrane transport (GO:1902600)3.10580772
100positive regulation of antigen processing and presentation (GO:0002579)3.09104556
101positive regulation of type 2 immune response (GO:0002830)3.08545854
102regulation of antigen processing and presentation (GO:0002577)3.07854122
103positive regulation of defense response to virus by host (GO:0002230)3.07728285
104regulation of T cell tolerance induction (GO:0002664)3.07193687
105negative regulation of type 2 immune response (GO:0002829)3.06291764
106regulation of interferon-beta biosynthetic process (GO:0045357)3.05353052
107response to peptidoglycan (GO:0032494)3.05069107
108cellular response to interferon-gamma (GO:0071346)2.99078968
109negative regulation of leukocyte mediated immunity (GO:0002704)2.98284170
110positive regulation of oligodendrocyte differentiation (GO:0048714)2.98237824
111* response to interferon-beta (GO:0035456)2.96495102
112deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.96350780
113catechol-containing compound biosynthetic process (GO:0009713)2.95907967
114catecholamine biosynthetic process (GO:0042423)2.95907967
115regulation of regulatory T cell differentiation (GO:0045589)2.95509857
116regulation of memory T cell differentiation (GO:0043380)2.94815149
117regulation of tolerance induction (GO:0002643)2.94292216
118positive regulation of interferon-beta production (GO:0032728)2.93841694
119DNA damage response, detection of DNA damage (GO:0042769)2.93578264
120indole-containing compound catabolic process (GO:0042436)2.93075063
121indolalkylamine catabolic process (GO:0046218)2.93075063
122tryptophan catabolic process (GO:0006569)2.93075063
123regulation of alpha-beta T cell proliferation (GO:0046640)2.92204982
124amyloid precursor protein metabolic process (GO:0042982)2.92204892
125germinal center formation (GO:0002467)2.91945563
126regulation of type 2 immune response (GO:0002828)2.91244210
127neurotransmitter uptake (GO:0001504)2.91060636
128response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.90282923
129response to host (GO:0075136)2.90282923
130response to host defenses (GO:0052200)2.90282923
131viral transcription (GO:0019083)2.90263403
132regulation of viral genome replication (GO:0045069)2.89225322
133response to interferon-gamma (GO:0034341)2.88224237
134response to protozoan (GO:0001562)2.87154036
135negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.86004023
136positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.85747039
137neutrophil activation involved in immune response (GO:0002283)2.85519585
138cellular response to ethanol (GO:0071361)2.85053967
139B cell mediated immunity (GO:0019724)2.83826356
140leukocyte aggregation (GO:0070486)2.83812883
141negative regulation of viral process (GO:0048525)2.83773843
142cellular extravasation (GO:0045123)2.82815315
143mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.81736286
144mitochondrial respiratory chain complex I assembly (GO:0032981)2.81736286
145NADH dehydrogenase complex assembly (GO:0010257)2.81736286
146negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.81702816
147proton transport (GO:0015992)2.81601710
148regulation of T-helper 1 cell differentiation (GO:0045625)2.81529674
149RNA destabilization (GO:0050779)2.80460466
150negative regulation of neurotransmitter secretion (GO:0046929)2.80226142
151neurotransmitter catabolic process (GO:0042135)2.80008055
152protein complex biogenesis (GO:0070271)2.79192588
153regulation of T cell mediated cytotoxicity (GO:0001914)2.78684367
154detection of biotic stimulus (GO:0009595)2.78524841
155protein targeting to mitochondrion (GO:0006626)2.77720753
156establishment of protein localization to mitochondrion (GO:0072655)2.77576813
157purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.76755253
158regulation of type I interferon-mediated signaling pathway (GO:0060338)2.75513745
159translational termination (GO:0006415)2.75504221
160positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.74326432
161hydrogen transport (GO:0006818)2.73938191
162positive thymic T cell selection (GO:0045059)2.73570726
163regulation of interleukin-12 biosynthetic process (GO:0045075)2.73222220
164regulation of interferon-beta production (GO:0032648)2.72372514
1657-methylguanosine RNA capping (GO:0009452)2.72323321
166RNA capping (GO:0036260)2.72323321
167cellular response to epinephrine stimulus (GO:0071872)2.71991396
1687-methylguanosine mRNA capping (GO:0006370)2.71193055
169cytokine biosynthetic process (GO:0042089)2.71038641
170positive regulation of tolerance induction (GO:0002645)2.69467614
171transmission of nerve impulse (GO:0019226)2.69335123
172regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.69174625
173purine nucleoside triphosphate biosynthetic process (GO:0009145)2.67057681
174positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.66966576
175negative regulation of adaptive immune response (GO:0002820)2.66736989
176phenol-containing compound catabolic process (GO:0019336)2.66360947
177cotranslational protein targeting to membrane (GO:0006613)2.64797302
178microtubule polymerization or depolymerization (GO:0031109)2.64273047
179neural nucleus development (GO:0048857)2.63696643
180ATP biosynthetic process (GO:0006754)2.62929433
181regulation of glutamate secretion (GO:0014048)2.62025253
182nucleoside diphosphate catabolic process (GO:0009134)2.61068407
183positive regulation of synapse assembly (GO:0051965)2.60572234
184neuron recognition (GO:0008038)2.59204243
185gamma-aminobutyric acid signaling pathway (GO:0007214)2.58141237
186establishment of mitochondrion localization (GO:0051654)2.57567381
187response to epinephrine (GO:0071871)2.55996808
188copper ion homeostasis (GO:0055070)2.54300429
189regulation of phospholipid biosynthetic process (GO:0071071)2.54104467
190UTP biosynthetic process (GO:0006228)2.53814586
191oligodendrocyte differentiation (GO:0048709)2.53807141
192protein localization to mitochondrion (GO:0070585)2.53366041
193lateral sprouting from an epithelium (GO:0060601)2.52888168
194intracellular protein transmembrane import (GO:0044743)2.51834391
195positive regulation of cellular amine metabolic process (GO:0033240)2.51663713
196synaptic transmission, dopaminergic (GO:0001963)2.51168802
197histone H2B ubiquitination (GO:0033523)2.51121386
198inner mitochondrial membrane organization (GO:0007007)2.50194568
199protein targeting to ER (GO:0045047)2.49890990
200mitochondrion morphogenesis (GO:0070584)2.48656678

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.13548584
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.48866450
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.00292061
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.97568082
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.06722143
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.87746528
7EZH2_22144423_ChIP-Seq_EOC_Human3.39521122
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.21196204
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.03328429
10SMAD_19615063_ChIP-ChIP_OVARY_Human3.03231139
11VDR_22108803_ChIP-Seq_LS180_Human3.01244408
12TAF15_26573619_Chip-Seq_HEK293_Human2.80403160
13GBX2_23144817_ChIP-Seq_PC3_Human2.70509786
14* IRF8_27001747_Chip-Seq_BMDM_Mouse2.57345665
15RUNX_20019798_ChIP-Seq_JUKART_Human2.39781770
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.38387066
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.35952158
18FUS_26573619_Chip-Seq_HEK293_Human2.34551063
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.34299120
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.32143565
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.27002277
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.26415562
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.21995263
24BP1_19119308_ChIP-ChIP_Hs578T_Human2.15685101
25JARID2_20064375_ChIP-Seq_MESCs_Mouse2.12868113
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12185631
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.08502291
28SCL_19346495_ChIP-Seq_HPC-7_Human2.04522566
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.00773136
30* MYB_26560356_Chip-Seq_TH2_Human2.00566556
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.95121100
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92848804
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.92154286
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.90322150
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.88043796
36GATA1_22025678_ChIP-Seq_K562_Human1.86710477
37ER_23166858_ChIP-Seq_MCF-7_Human1.85066804
38VDR_24787735_ChIP-Seq_THP-1_Human1.83792209
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.82424080
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.81879142
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.79722663
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.78734934
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.77778115
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77112527
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.75767512
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.75437585
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73246544
48POU5F1_16153702_ChIP-ChIP_HESCs_Human1.73012573
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.69949917
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69590091
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.66824033
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65436472
53KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.64610394
54KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.64610394
55KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.64610394
56P300_19829295_ChIP-Seq_ESCs_Human1.63474996
57NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62987697
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.60808105
59STAT4_19710469_ChIP-ChIP_TH1__Mouse1.60199963
60RNF2_18974828_ChIP-Seq_MESCs_Mouse1.57697605
61EZH2_18974828_ChIP-Seq_MESCs_Mouse1.57697605
62GATA3_27048872_Chip-Seq_THYMUS_Human1.57549162
63SPI1_23127762_ChIP-Seq_K562_Human1.56553743
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53434573
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53221846
66JARID2_20075857_ChIP-Seq_MESCs_Mouse1.52143330
67GATA3_26560356_Chip-Seq_TH2_Human1.50665480
68MYB_21317192_ChIP-Seq_ERMYB_Mouse1.50356189
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43940189
70* MYB_26560356_Chip-Seq_TH1_Human1.43244032
71STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42659215
72SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40424741
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40273411
74RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40120800
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.39246439
76E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.37807555
77BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.36064107
78MTF2_20144788_ChIP-Seq_MESCs_Mouse1.35886203
79RNF2_27304074_Chip-Seq_NSC_Mouse1.35005306
80GATA2_21666600_ChIP-Seq_HMVEC_Human1.34544338
81SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32599122
82PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32119792
83SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30605725
84NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30139678
85SPI1_23547873_ChIP-Seq_NB4_Human1.29311945
86FLI1_27457419_Chip-Seq_LIVER_Mouse1.27815742
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.27131434
88EZH2_27294783_Chip-Seq_ESCs_Mouse1.26507650
89PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25184311
90IGF1R_20145208_ChIP-Seq_DFB_Human1.24751783
91DROSHA_22980978_ChIP-Seq_HELA_Human1.24097516
92RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22473680
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21333202
94VDR_24763502_ChIP-Seq_THP-1_Human1.21000441
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20956572
96EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19943632
97VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.18814234
98HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18663588
99CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17917646
100REST_21632747_ChIP-Seq_MESCs_Mouse1.17226142
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16748316
102ETS1_20019798_ChIP-Seq_JURKAT_Human1.16652835
103EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15936708
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14345737
105EWS_26573619_Chip-Seq_HEK293_Human1.14323599
106GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13666061
107CMYC_18555785_Chip-Seq_ESCs_Mouse1.13315255
108PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12921011
109SMRT_27268052_Chip-Seq_Bcells_Human1.12827363
110RNF2_27304074_Chip-Seq_ESCs_Mouse1.12521589
111SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12221990
112PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11344059
113WT1_19549856_ChIP-ChIP_CCG9911_Human1.11178082
114EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10773806
115P300_18555785_Chip-Seq_ESCs_Mouse1.10561886
116SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09841055
117* MAF_26560356_Chip-Seq_TH1_Human1.09404271
118IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08637803
119E2F1_18555785_Chip-Seq_ESCs_Mouse1.07359178
120TAL1_26923725_Chip-Seq_HPCs_Mouse1.06784588
121NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06553579
122GATA1_26923725_Chip-Seq_HPCs_Mouse1.06219362
123LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05825567
124IRF1_19129219_ChIP-ChIP_H3396_Human1.05378190
125CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04099791
126HTT_18923047_ChIP-ChIP_STHdh_Human1.03780425
127STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03749454
128GATA1_19941827_ChIP-Seq_MEL_Mouse1.03224831
129CREB1_15753290_ChIP-ChIP_HEK293T_Human1.02417208
130IRF8_21731497_ChIP-ChIP_J774_Mouse1.02405287
131FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02007803
132PRDM14_20953172_ChIP-Seq_ESCs_Human1.01845787
133PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01562193
134PIAS1_25552417_ChIP-Seq_VCAP_Human0.98951298
135MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98813394
136STAT3_18555785_Chip-Seq_ESCs_Mouse0.98442499
137SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97775148
138P53_22387025_ChIP-Seq_ESCs_Mouse0.96869325
139JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.96661503
140JUN_21703547_ChIP-Seq_K562_Human0.96383297
141RUNX1_27457419_Chip-Seq_LIVER_Mouse0.96365930
142SOX2_18555785_Chip-Seq_ESCs_Mouse0.96355866
143EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95609008
144SMAD1_18555785_Chip-Seq_ESCs_Mouse0.95270090
145CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94681910
146KLF4_18555785_Chip-Seq_ESCs_Mouse0.94560870
147TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94454608
148ELK1_19687146_ChIP-ChIP_HELA_Human0.93438913
149AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93125900
150RUNX2_22187159_ChIP-Seq_PCA_Human0.92203501
151GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92154083
152TP53_18474530_ChIP-ChIP_U2OS_Human0.92134478
153RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92074390
154RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.91341765
155BCAT_22108803_ChIP-Seq_LS180_Human0.91170658
156SMAD4_21799915_ChIP-Seq_A2780_Human0.90781427
157TP53_16413492_ChIP-PET_HCT116_Human0.89591816
158SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88303383
159NFE2_27457419_Chip-Seq_LIVER_Mouse0.87839721
160PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87113988
161RUNX1_22412390_ChIP-Seq_EML_Mouse0.86743440
162* STAT3_23295773_ChIP-Seq_U87_Human0.85875105
163GATA1_19941826_ChIP-Seq_K562_Human0.85849617
164EZH2_27294783_Chip-Seq_NPCs_Mouse0.85712739
165PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.83050760
166ESR1_20079471_ChIP-ChIP_T-47D_Human0.83009294
167BRD4_27068464_Chip-Seq_AML-cells_Mouse0.82859132
168RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82149669
169OCT4_21477851_ChIP-Seq_ESCs_Mouse0.81899356
170GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81706982
171PU_27001747_Chip-Seq_BMDM_Mouse0.81276057
172CDX2_22108803_ChIP-Seq_LS180_Human0.79880708
173FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78554450
174MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.78229517
175CRX_20693478_ChIP-Seq_RETINA_Mouse0.77811328
176* UTX_26944678_Chip-Seq_JUKART_Human0.77787471
177TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.77590503
178FOXA1_21572438_ChIP-Seq_LNCaP_Human0.76732095
179* TCF4_23295773_ChIP-Seq_U87_Human0.76694306
180TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.76143991
181JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75486969
182NOTCH1_21737748_ChIP-Seq_TLL_Human0.74709452
183GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.74161676
184GATA3_26560356_Chip-Seq_TH1_Human0.73916746
185TP63_23658742_ChIP-Seq_EP156T_Human0.73672287
186STAT1_20625510_ChIP-Seq_HELA_Human0.73053901

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.86447519
2MP0001835_abnormal_antigen_presentation4.43721694
3MP0005423_abnormal_somatic_nervous3.55546963
4MP0001529_abnormal_vocalization3.53355409
5MP0001905_abnormal_dopamine_level3.45879290
6MP0005671_abnormal_response_to3.28591990
7MP0003136_yellow_coat_color3.15383943
8MP0001800_abnormal_humoral_immune3.14026011
9MP0001790_abnormal_immune_system3.09961581
10MP0005387_immune_system_phenotype3.09961581
11MP0009379_abnormal_foot_pigmentation3.09200780
12MP0000920_abnormal_myelination3.02721819
13MP0003303_peritoneal_inflammation2.98809957
14MP0003436_decreased_susceptibility_to2.86632344
15MP0000685_abnormal_immune_system2.82023262
16MP0005025_abnormal_response_to2.81316064
17MP0005000_abnormal_immune_tolerance2.79968615
18MP0005409_darkened_coat_color2.69967669
19MP0002723_abnormal_immune_serum2.66687524
20MP0002452_abnormal_antigen_presenting2.53510378
21MP0002419_abnormal_innate_immunity2.52771398
22MP0003763_abnormal_thymus_physiology2.52278604
23MP0000569_abnormal_digit_pigmentation2.42718990
24MP0002064_seizures2.41916553
25MP0002420_abnormal_adaptive_immunity2.33732019
26MP0002272_abnormal_nervous_system2.33349587
27MP0006276_abnormal_autonomic_nervous2.32766811
28MP0001819_abnormal_immune_cell2.32432989
29MP0004270_analgesia2.30468932
30MP0005171_absent_coat_pigmentation2.27860901
31MP0004742_abnormal_vestibular_system2.26224359
32MP0009745_abnormal_behavioral_response2.23125960
33MP0004142_abnormal_muscle_tone2.21287875
34MP0009046_muscle_twitch2.18543987
35MP0001486_abnormal_startle_reflex2.16742918
36MP0001986_abnormal_taste_sensitivity2.08888041
37MP0000778_abnormal_nervous_system2.05389502
38MP0001968_abnormal_touch/_nociception2.00446959
39MP0002102_abnormal_ear_morphology1.98004633
40MP0003635_abnormal_synaptic_transmissio1.97073013
41MP0010155_abnormal_intestine_physiology1.96766445
42MP0002138_abnormal_hepatobiliary_system1.96392816
43MP0001188_hyperpigmentation1.94856768
44MP0001440_abnormal_grooming_behavior1.93244531
45MP0005310_abnormal_salivary_gland1.84944724
46MP0003300_gastrointestinal_ulcer1.84568620
47MP0002572_abnormal_emotion/affect_behav1.83722948
48MP0000716_abnormal_immune_system1.80400117
49MP0009764_decreased_sensitivity_to1.78600835
50MP0002734_abnormal_mechanical_nocicepti1.78228994
51MP0002405_respiratory_system_inflammati1.75719374
52MP0001845_abnormal_inflammatory_respons1.75532949
53MP0001533_abnormal_skeleton_physiology1.70606025
54MP0002398_abnormal_bone_marrow1.70068482
55MP0002277_abnormal_respiratory_mucosa1.69370605
56MP0002736_abnormal_nociception_after1.69193857
57MP0003045_fibrosis1.65787725
58MP0004381_abnormal_hair_follicle1.62789330
59MP0002166_altered_tumor_susceptibility1.59658438
60MP0001485_abnormal_pinna_reflex1.59462586
61MP0001501_abnormal_sleep_pattern1.55967668
62MP0001970_abnormal_pain_threshold1.53923150
63MP0003195_calcinosis1.52100991
64MP0002067_abnormal_sensory_capabilities1.51267260
65MP0002733_abnormal_thermal_nociception1.51072930
66MP0002063_abnormal_learning/memory/cond1.50952129
67MP0000372_irregular_coat_pigmentation1.50621044
68MP0003690_abnormal_glial_cell1.49913248
69MP0008469_abnormal_protein_level1.49341978
70MP0002735_abnormal_chemical_nociception1.49334355
71MP0005464_abnormal_platelet_physiology1.48815863
72MP0003329_amyloid_beta_deposits1.46635600
73MP0000689_abnormal_spleen_morphology1.46185904
74MP0003183_abnormal_peptide_metabolism1.46128394
75MP0006292_abnormal_olfactory_placode1.45751265
76MP0003938_abnormal_ear_development1.44134400
77MP0003950_abnormal_plasma_membrane1.43939735
78MP0009333_abnormal_splenocyte_physiolog1.43817290
79MP0003866_abnormal_defecation1.43781927
80MP0004924_abnormal_behavior1.41734241
81MP0005386_behavior/neurological_phenoty1.41734241
82MP0003634_abnormal_glial_cell1.38825082
83MP0004947_skin_inflammation1.38432007
84MP0000566_synostosis1.34971786
85MP0002822_catalepsy1.34915861
86MP0005379_endocrine/exocrine_gland_phen1.34866209
87MP0004859_abnormal_synaptic_plasticity1.32938170
88MP0002429_abnormal_blood_cell1.32682944
89MP0002722_abnormal_immune_system1.32409144
90MP0008057_abnormal_DNA_replication1.31846388
91MP0004145_abnormal_muscle_electrophysio1.30636849
92MP0005551_abnormal_eye_electrophysiolog1.29062661
93MP0003172_abnormal_lysosome_physiology1.28447303
94MP0001873_stomach_inflammation1.28180675
95MP0003252_abnormal_bile_duct1.26154741
96MP0003724_increased_susceptibility_to1.23646112
97MP0002229_neurodegeneration1.23067411
98MP0002163_abnormal_gland_morphology1.22678605
99MP0002184_abnormal_innervation1.21398354
100MP0000462_abnormal_digestive_system1.21324140
101MP0003646_muscle_fatigue1.19242412
102MP0005410_abnormal_fertilization1.18248746
103MP0002006_tumorigenesis1.17535616
104MP0004883_abnormal_blood_vessel1.12522888
105MP0000703_abnormal_thymus_morphology1.12128386
106MP0002882_abnormal_neuron_morphology1.11841067
107MP0002752_abnormal_somatic_nervous1.10620481
108MP0003718_maternal_effect1.10035312
109MP0001545_abnormal_hematopoietic_system1.08644909
110MP0005397_hematopoietic_system_phenotyp1.08644909
111MP0002998_abnormal_bone_remodeling1.08318536
112MP0004510_myositis1.08090612
113MP0001963_abnormal_hearing_physiology1.07657094
114MP0000465_gastrointestinal_hemorrhage1.06934773
115MP0002066_abnormal_motor_capabilities/c1.06260334
116MP0009278_abnormal_bone_marrow1.06059958
117MP0000955_abnormal_spinal_cord1.04717975
118MP0006072_abnormal_retinal_apoptosis1.04193795
119MP0003632_abnormal_nervous_system1.04065367
120MP0002396_abnormal_hematopoietic_system1.01456718
121MP0000026_abnormal_inner_ear1.00794016
122MP0003191_abnormal_cellular_cholesterol0.99871013
123MP0002933_joint_inflammation0.98704253
124MP0002557_abnormal_social/conspecific_i0.97412946
125MP0004885_abnormal_endolymph0.97253855
126MP0002938_white_spotting0.96803530
127MP0002332_abnormal_exercise_endurance0.96275068
128MP0009763_increased_sensitivity_to0.95560057
129MP0005164_abnormal_response_to0.94410805
130MP0006082_CNS_inflammation0.93415449
131MP0010386_abnormal_urinary_bladder0.93077739
132MP0000762_abnormal_tongue_morphology0.92670426
133MP0005075_abnormal_melanosome_morpholog0.91806595
134MP0005408_hypopigmentation0.90221586
135MP0004130_abnormal_muscle_cell0.88256587
136MP0005166_decreased_susceptibility_to0.86961769
137MP0002751_abnormal_autonomic_nervous0.86470155
138MP0005167_abnormal_blood-brain_barrier0.85867806
139MP0000371_diluted_coat_color0.84679458
140MP0006054_spinal_hemorrhage0.84382548
141MP0001727_abnormal_embryo_implantation0.82996470
142MP0003828_pulmonary_edema0.82890713
143MP0000858_altered_metastatic_potential0.81963165
144MP0002638_abnormal_pupillary_reflex0.81685531
145MP0000383_abnormal_hair_follicle0.81159642
146MP0003075_altered_response_to0.79879528
147MP0003631_nervous_system_phenotype0.79529895
148MP0002168_other_aberrant_phenotype0.79143404
149MP0002148_abnormal_hypersensitivity_rea0.77775277
150MP0000249_abnormal_blood_vessel0.77686066
151MP0005195_abnormal_posterior_eye0.77481746
152MP0001346_abnormal_lacrimal_gland0.77478785
153MP0001853_heart_inflammation0.76176313
154MP0000343_altered_response_to0.75382872
155MP0009115_abnormal_fat_cell0.74530690
156MP0008872_abnormal_physiological_respon0.74241787
157MP0000015_abnormal_ear_pigmentation0.73561131
158MP0005451_abnormal_body_composition0.72908378
159MP0001663_abnormal_digestive_system0.72885454
160MP0003656_abnormal_erythrocyte_physiolo0.72738720
161MP0005253_abnormal_eye_physiology0.72689049
162MP0009785_altered_susceptibility_to0.72472400
163MP0002152_abnormal_brain_morphology0.70975772
164MP0000613_abnormal_salivary_gland0.69871243
165MP0004808_abnormal_hematopoietic_stem0.69478187
166MP0003448_altered_tumor_morphology0.67983018
167MP0005174_abnormal_tail_pigmentation0.67423992
168MP0008877_abnormal_DNA_methylation0.66768406
169MP0002693_abnormal_pancreas_physiology0.66061265
170MP0005085_abnormal_gallbladder_physiolo0.65963030
171MP0004133_heterotaxia0.65780118
172MP0008260_abnormal_autophagy0.64798831
173MP0008874_decreased_physiological_sensi0.64736165
174MP0001851_eye_inflammation0.64355107
175MP0009765_abnormal_xenobiotic_induced0.63927872
176MP0004043_abnormal_pH_regulation0.62389525
177MP0000604_amyloidosis0.62147349
178MP0002295_abnormal_pulmonary_circulatio0.62056683
179MP0003806_abnormal_nucleotide_metabolis0.61835669
180MP0000647_abnormal_sebaceous_gland0.61782004
181MP0002132_abnormal_respiratory_system0.61748656
182MP0005376_homeostasis/metabolism_phenot0.61230399
183MP0006035_abnormal_mitochondrial_morpho0.59510041
184MP0001177_atelectasis0.58670107
185MP0010678_abnormal_skin_adnexa0.57484151
186MP0008569_lethality_at_weaning0.57271574
187MP0000631_abnormal_neuroendocrine_gland0.56360325

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)5.18826994
2Optic neuritis (HP:0100653)5.05016410
3Retrobulbar optic neuritis (HP:0100654)5.05016410
4Myositis (HP:0100614)4.99772901
5Orchitis (HP:0100796)4.87606285
6Acute necrotizing encephalopathy (HP:0006965)4.60243367
7Recurrent bacterial skin infections (HP:0005406)4.47581956
8Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.44265223
9Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.39950816
10Elevated erythrocyte sedimentation rate (HP:0003565)4.28624272
11Eczematoid dermatitis (HP:0000976)4.26741286
12Recurrent cutaneous fungal infections (HP:0011370)4.24506734
13Chronic mucocutaneous candidiasis (HP:0002728)4.24506734
14Recurrent abscess formation (HP:0002722)4.22059166
15Stomatitis (HP:0010280)4.20130998
16Recurrent fungal infections (HP:0002841)4.17443077
17Abnormal delayed hypersensitivity skin test (HP:0002963)4.16790325
18Abnormality of T cell number (HP:0011839)3.98547472
19Mitochondrial inheritance (HP:0001427)3.96485945
20Neurofibrillary tangles (HP:0002185)3.96408358
21T lymphocytopenia (HP:0005403)3.85088481
22Progressive macrocephaly (HP:0004481)3.84256287
23Genetic anticipation (HP:0003743)3.82602755
24Renal Fanconi syndrome (HP:0001994)3.81901595
25Abnormal mitochondria in muscle tissue (HP:0008316)3.79396937
26Duplicated collecting system (HP:0000081)3.79178893
27Progressive external ophthalmoplegia (HP:0000590)3.74102501
28Increased hepatocellular lipid droplets (HP:0006565)3.70255376
29Vasculitis (HP:0002633)3.70069638
30Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.61472617
31Keratoconjunctivitis sicca (HP:0001097)3.61169989
32Recurrent skin infections (HP:0001581)3.55933320
33Hemoptysis (HP:0002105)3.55080888
34Acute encephalopathy (HP:0006846)3.50633618
35Gastrointestinal infarctions (HP:0005244)3.48763346
36Keratoconjunctivitis (HP:0001096)3.47780333
37Degeneration of the lateral corticospinal tracts (HP:0002314)3.43542183
38Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.43542183
39Pulmonary infiltrates (HP:0002113)3.41037213
40Mediastinal lymphadenopathy (HP:0100721)3.36271701
41Encephalitis (HP:0002383)3.33707495
42Meningitis (HP:0001287)3.32534790
43Cerebral inclusion bodies (HP:0100314)3.29886300
44Recurrent viral infections (HP:0004429)3.26310123
45Limb dystonia (HP:0002451)3.26091557
46Recurrent gram-negative bacterial infections (HP:0005420)3.25515139
47Hepatocellular necrosis (HP:0001404)3.23337357
48Abnormality of the renal collecting system (HP:0004742)3.22101946
49Congenital ichthyosiform erythroderma (HP:0007431)3.19152978
50Spontaneous hematomas (HP:0007420)3.13316099
51Recurrent bronchitis (HP:0002837)3.13308732
52Leukodystrophy (HP:0002415)3.13242080
53Abnormality of T cells (HP:0002843)3.11200900
54Autoimmune hemolytic anemia (HP:0001890)3.09184290
55Sensory axonal neuropathy (HP:0003390)3.06092741
56Increased CSF lactate (HP:0002490)3.02261254
57Lipid accumulation in hepatocytes (HP:0006561)3.00594432
58Gingivitis (HP:0000230)2.91793879
59Arterial thrombosis (HP:0004420)2.90047807
60Gingival bleeding (HP:0000225)2.88649723
61Optic disc pallor (HP:0000543)2.88105538
623-Methylglutaconic aciduria (HP:0003535)2.85661217
63Panhypogammaglobulinemia (HP:0003139)2.85269399
64Broad-based gait (HP:0002136)2.85104663
65Autoimmune thrombocytopenia (HP:0001973)2.81187912
66Leukocytosis (HP:0001974)2.77483687
67Chest pain (HP:0100749)2.73574394
68Increased neuronal autofluorescent lipopigment (HP:0002074)2.73219666
69Increased intramyocellular lipid droplets (HP:0012240)2.73035836
70Abnormality of glycolysis (HP:0004366)2.69909981
71Increased serum pyruvate (HP:0003542)2.69909981
72Abnormality of T cell physiology (HP:0011840)2.64514211
73Hypoplastic nipples (HP:0002557)2.64319729
74Chronic otitis media (HP:0000389)2.63941569
75Pulmonary embolism (HP:0002204)2.62491094
76Increased cerebral lipofuscin (HP:0011813)2.61099269
77Pustule (HP:0200039)2.59804293
78Inflammation of the large intestine (HP:0002037)2.56313027
79IgG deficiency (HP:0004315)2.55135656
80Chronic obstructive pulmonary disease (HP:0006510)2.54741166
81Obstructive lung disease (HP:0006536)2.54741166
82Progressive cerebellar ataxia (HP:0002073)2.54441808
83Eosinophilia (HP:0001880)2.52807327
84Prostate neoplasm (HP:0100787)2.51156423
85Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.51123366
86Exercise intolerance (HP:0003546)2.50939625
87Hypochromic anemia (HP:0001931)2.50117754
88Breast hypoplasia (HP:0003187)2.49668723
89Retinal dysplasia (HP:0007973)2.49470031
90Colitis (HP:0002583)2.48961969
91Epistaxis (HP:0000421)2.48612699
92Hypochromic microcytic anemia (HP:0004840)2.46890869
93Exertional dyspnea (HP:0002875)2.46633213
94Abnormality of the pleura (HP:0002103)2.46383484
95Gangrene (HP:0100758)2.46057705
96Stomach cancer (HP:0012126)2.46042888
97Cerebral hemorrhage (HP:0001342)2.45115925
98Anorexia (HP:0002039)2.44760028
99Cerebral hypomyelination (HP:0006808)2.44156677
100Abnormality of the corticospinal tract (HP:0002492)2.43791187
101Chronic diarrhea (HP:0002028)2.43755858
102Abnormality of renal resorption (HP:0011038)2.41759406
103Abnormal ciliary motility (HP:0012262)2.41232634
104Increased IgE level (HP:0003212)2.40781625
105Prolonged bleeding time (HP:0003010)2.38555510
106Peripheral hypomyelination (HP:0007182)2.36361609
107Systemic lupus erythematosus (HP:0002725)2.35238182
108Gastrointestinal inflammation (HP:0004386)2.35007415
109Granulocytopenia (HP:0001913)2.34746624
110Hepatic necrosis (HP:0002605)2.34145919
111Septo-optic dysplasia (HP:0100842)2.32910510
112Abnormality of the prostate (HP:0008775)2.32902711
113Agammaglobulinemia (HP:0004432)2.31527035
114Abnormality of eosinophils (HP:0001879)2.31198550
115Macrocytic anemia (HP:0001972)2.28031934
116Hypoplastic pelvis (HP:0008839)2.27594304
117Respiratory failure (HP:0002878)2.26096122
118Abnormality of secondary sexual hair (HP:0009888)2.25395359
119Abnormality of the axillary hair (HP:0100134)2.25395359
120Hypergammaglobulinemia (HP:0010702)2.24212191
121Lymphopenia (HP:0001888)2.21372237
122Urticaria (HP:0001025)2.21145319
123Hematochezia (HP:0002573)2.19449127
124Abnormality of B cell number (HP:0010975)2.17777060
125Myokymia (HP:0002411)2.17699889
126Overfolded helix (HP:0000396)2.17606869
127Abnormality of cells of the lymphoid lineage (HP:0012140)2.17124218
128Clumsiness (HP:0002312)2.16900170
129Focal motor seizures (HP:0011153)2.15277108
130Abnormality of the endocardium (HP:0004306)2.14623103
131Vertigo (HP:0002321)2.14469192
132External ophthalmoplegia (HP:0000544)2.14179336
133Abnormality of the septum pellucidum (HP:0007375)2.13166977
134Cerebral edema (HP:0002181)2.12297900
135Abnormality of the pericardium (HP:0001697)2.11823297
136Peritonitis (HP:0002586)2.10956118
137Erythroderma (HP:0001019)2.09539776
138Gaze-evoked nystagmus (HP:0000640)2.09249594
139Absent septum pellucidum (HP:0001331)2.06588882
140Hypothermia (HP:0002045)2.06522756
141Increased IgM level (HP:0003496)2.04174647
142Joint swelling (HP:0001386)2.03893682
143Gastrointestinal stroma tumor (HP:0100723)2.03716788
144Hepatosplenomegaly (HP:0001433)2.03690544
145Cheilitis (HP:0100825)2.03355319
146Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.03236943
147Decreased activity of mitochondrial respiratory chain (HP:0008972)2.03236943
148Absent/shortened dynein arms (HP:0200106)2.02180061
149Dynein arm defect of respiratory motile cilia (HP:0012255)2.02180061
150Supranuclear gaze palsy (HP:0000605)2.01634829
151Keratitis (HP:0000491)1.99579817
152IgA deficiency (HP:0002720)1.96916838
153Increased muscle lipid content (HP:0009058)1.96371183
154Dysmetria (HP:0001310)1.95990023
155Conical tooth (HP:0000698)1.94641789
156Thyroiditis (HP:0100646)1.94505503
157Abnormality of placental membranes (HP:0011409)1.93979109
158Amniotic constriction ring (HP:0009775)1.93979109
159Increased serum lactate (HP:0002151)1.93330206
160Abnormal pupillary function (HP:0007686)1.92467498
161X-linked dominant inheritance (HP:0001423)1.91998707
162Pulmonary artery stenosis (HP:0004415)1.91668170
163Slow saccadic eye movements (HP:0000514)1.91583106
164Malnutrition (HP:0004395)1.91065032
165Delusions (HP:0000746)1.90734688
166Hemiplegia (HP:0002301)1.90566646
167Neuroendocrine neoplasm (HP:0100634)1.90399951
168Abnormal respiratory motile cilium physiology (HP:0012261)1.90282281
169Abnormality of macrophages (HP:0004311)1.89499442
170Abnormal respiratory epithelium morphology (HP:0012253)1.88784946
171Abnormal respiratory motile cilium morphology (HP:0005938)1.88784946
172Basal ganglia calcification (HP:0002135)1.88711329
173Cupped ear (HP:0000378)1.88139290
174Abnormally folded helix (HP:0008544)1.87628046
175Microcytic anemia (HP:0001935)1.86657678
176Respiratory difficulties (HP:0002880)1.85999606
177Polyneuropathy (HP:0001271)1.85779733
178Neoplasm of the tracheobronchial system (HP:0100552)1.85757980
179Adactyly (HP:0009776)1.85335657
180Recurrent sinusitis (HP:0011108)1.84389657
181Episodic fever (HP:0001954)1.84139004
182Facial diplegia (HP:0001349)1.83387784
183Aplasia/Hypoplasia of the sacrum (HP:0008517)1.82162892
184Anomalous pulmonary venous return (HP:0010772)1.80325711
185Abnormality of cells of the erythroid lineage (HP:0012130)1.80263414
186Morphological abnormality of the inner ear (HP:0011390)1.74778868
187Vaginal atresia (HP:0000148)1.74204885
188Genital tract atresia (HP:0001827)1.72868213
189Pheochromocytoma (HP:0002666)1.72395065
190Akinesia (HP:0002304)1.71522310
191Absent hand (HP:0004050)1.68768182
192Diminished movement (HP:0002374)1.68661802
193Split foot (HP:0001839)1.65337071
194Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.64854671
195Aplasia of the musculature (HP:0100854)1.64645724
196Aplasia involving forearm bones (HP:0009822)1.64350380
197Absent forearm bone (HP:0003953)1.64350380
198Abnormal hair whorl (HP:0010721)1.64067919

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.19768703
2PNCK3.87026759
3STK393.52541260
4MAP4K13.38884436
5TYK23.24414989
6TXK3.08827634
7PBK2.80795567
8IKBKE2.66250747
9JAK12.64374584
10STK162.64129074
11MARK12.62858242
12JAK32.55189741
13CDK192.51015029
14TAOK32.50390829
15KIT2.43953276
16OXSR12.43149096
17TNIK2.40178928
18IRAK22.33752796
19CASK2.21109756
20IRAK32.12083159
21MST42.10673696
22MAPKAPK52.10616593
23BUB12.05445945
24TNK22.00312143
25FGR1.95902270
26MAP3K141.89154678
27BCR1.86610746
28CSK1.86546346
29IRAK41.82748846
30PKN11.81270357
31ACVR1B1.80393693
32FGFR41.74558443
33BTK1.72753174
34TLK11.66553727
35SYK1.64488221
36TBK11.63016146
37ADRBK21.61634255
38TEC1.60324707
39FGFR31.59166299
40RIPK41.58554176
41IRAK11.54910988
42ARAF1.54080912
43ZAP701.45610721
44IKBKB1.43042416
45NME11.41524747
46GRK71.40451727
47CSNK1G31.37671693
48BMPR1B1.36075296
49ITK1.36040375
50PIK3CG1.33846858
51BMPR21.31014012
52ROCK21.30549352
53CAMK2B1.28926807
54MAP3K121.26590229
55GRK51.26425167
56JAK21.23868089
57HCK1.23320839
58LCK1.22726715
59EPHA41.21262683
60MAP2K71.20291915
61ERN11.19480328
62NLK1.17835238
63PLK41.17177109
64PLK21.15292211
65MAP3K71.14960733
66CSF1R1.14956995
67MAP2K31.11611216
68MATK1.10907547
69NTRK11.08957133
70UHMK11.07788522
71EPHB11.07166564
72WNK41.05777338
73VRK11.03665741
74FES0.99490319
75MARK30.98737497
76CAMK2D0.97661438
77CSNK1G20.96642618
78DYRK20.96316593
79NEK60.96115098
80MAPK150.95040012
81CSNK1G10.92834047
82ABL20.90453171
83CAMK2A0.89034725
84EPHA30.86977671
85NTRK30.86645720
86TGFBR20.85864040
87MAPK110.85788551
88MAPK70.85111948
89WEE10.84285774
90MAP3K130.83511304
91CHUK0.82603104
92PDK10.78214511
93PRPF4B0.76171794
94TRPM70.75027668
95MAP3K30.74615185
96LIMK10.74480651
97HIPK20.74210381
98MAP3K40.73848562
99CSNK1A1L0.73796633
100RIPK10.70990367
101MET0.70253062
102MAPK130.70097876
103MAP3K90.70064629
104BLK0.69138934
105PRKCE0.68220664
106CLK10.68095270
107CAMK2G0.67802791
108MAP2K60.67358101
109RPS6KA50.62818473
110BRAF0.62620611
111STK380.61927695
112PIM10.61490351
113CDK140.60302513
114MELK0.59519743
115SRPK10.58441504
116MARK20.57264441
117ZAK0.57065996
118GRK60.56935972
119TAOK10.56825357
120MKNK10.54526858
121CDK11A0.52539157
122ADRBK10.52317379
123MAP3K10.50603723
124NME20.49942930
125PRKAA20.49084143
126DAPK20.48850252
127CDK150.48504419
128STK100.48307482
129CAMKK20.47477671
130CDC42BPA0.47415501
131NTRK20.47106851
132PDPK10.46851319
133PRKCQ0.46511920
134STK110.45911200
135MAP3K60.45546541
136CDK180.45423543
137CDK50.45262772
138GRK10.45220724
139PTK2B0.44719155
140MINK10.42839261
141SIK30.41920610
142MUSK0.40713487
143ABL10.40652847
144PLK30.39924117
145SIK20.37831126
146SGK20.37207780
147PIK3CA0.36880941
148FER0.36659597
149PRKACA0.36581964
150MAPK120.36407037
151MAP3K110.35263831
152MOS0.35185270
153EIF2AK30.35009097
154CSNK1E0.34164742
155PRKCH0.33901854
156DYRK1A0.33139832
157TESK20.33006905
158PRKCG0.32910534
159WNK10.32388878
160YES10.30158486
161FYN0.29986526
162LYN0.28999612
163PRKD20.28919239
164MYLK0.28815569
165EGFR0.28760220
166PDGFRB0.28330914
167IGF1R0.28204164
168AURKA0.28117576
169PHKG20.28025833
170PHKG10.28025833
171CSNK2A20.27376075
172NUAK10.26054167
173MAPK30.25986541
174MAP3K50.25604074
175MAPKAPK30.24721831
176CDK40.23231086

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.11979388
2Parkinsons disease_Homo sapiens_hsa050124.12808541
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.88229823
4Alzheimers disease_Homo sapiens_hsa050103.37578394
5Ribosome_Homo sapiens_hsa030103.37524166
6Steroid biosynthesis_Homo sapiens_hsa001002.93122105
7Huntingtons disease_Homo sapiens_hsa050162.90325784
8Staphylococcus aureus infection_Homo sapiens_hsa051502.82108801
9Proteasome_Homo sapiens_hsa030502.69980564
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.61016283
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.58314715
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.48769409
13RNA polymerase_Homo sapiens_hsa030202.47601831
14Leishmaniasis_Homo sapiens_hsa051402.47466704
15Fatty acid elongation_Homo sapiens_hsa000622.46023581
16Primary immunodeficiency_Homo sapiens_hsa053402.39542641
17Osteoclast differentiation_Homo sapiens_hsa043802.11298906
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.10673877
19Collecting duct acid secretion_Homo sapiens_hsa049662.10638637
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.06608378
21Measles_Homo sapiens_hsa051622.04905333
22Ether lipid metabolism_Homo sapiens_hsa005652.04859933
23Protein export_Homo sapiens_hsa030601.99719291
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.92531024
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.92129683
26Influenza A_Homo sapiens_hsa051641.89642504
27Antigen processing and presentation_Homo sapiens_hsa046121.85192141
28Cardiac muscle contraction_Homo sapiens_hsa042601.80312479
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.78804405
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73960798
31Nicotine addiction_Homo sapiens_hsa050331.73331254
32Tuberculosis_Homo sapiens_hsa051521.67132165
33Serotonergic synapse_Homo sapiens_hsa047261.65843175
34B cell receptor signaling pathway_Homo sapiens_hsa046621.64300125
35Herpes simplex infection_Homo sapiens_hsa051681.62415580
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.57626952
37Hematopoietic cell lineage_Homo sapiens_hsa046401.55834244
38Phototransduction_Homo sapiens_hsa047441.48635192
39Toxoplasmosis_Homo sapiens_hsa051451.47755717
40Viral myocarditis_Homo sapiens_hsa054161.46752664
41Rheumatoid arthritis_Homo sapiens_hsa053231.43976665
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.39870263
43TNF signaling pathway_Homo sapiens_hsa046681.37260388
44T cell receptor signaling pathway_Homo sapiens_hsa046601.36547543
45Hepatitis C_Homo sapiens_hsa051601.34685490
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.32770911
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27958148
48Chemokine signaling pathway_Homo sapiens_hsa040621.24489489
49African trypanosomiasis_Homo sapiens_hsa051431.21496363
50GABAergic synapse_Homo sapiens_hsa047271.18036188
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14641047
52Glutamatergic synapse_Homo sapiens_hsa047241.12451322
53Vibrio cholerae infection_Homo sapiens_hsa051101.12437878
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10860523
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09662881
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09427937
57Axon guidance_Homo sapiens_hsa043601.09260323
58Linoleic acid metabolism_Homo sapiens_hsa005911.07483572
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06834409
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.06654197
61Long-term depression_Homo sapiens_hsa047301.05544219
62Graft-versus-host disease_Homo sapiens_hsa053321.03533395
63Sphingolipid metabolism_Homo sapiens_hsa006001.03375545
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03027878
65ABC transporters_Homo sapiens_hsa020101.00097819
66Platelet activation_Homo sapiens_hsa046110.99975631
67Allograft rejection_Homo sapiens_hsa053300.99034774
68Dorso-ventral axis formation_Homo sapiens_hsa043200.98515720
69Morphine addiction_Homo sapiens_hsa050320.97768695
70Legionellosis_Homo sapiens_hsa051340.93520608
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.93475590
72Autoimmune thyroid disease_Homo sapiens_hsa053200.90548972
73Hepatitis B_Homo sapiens_hsa051610.88857316
74Pyrimidine metabolism_Homo sapiens_hsa002400.87653970
75Arachidonic acid metabolism_Homo sapiens_hsa005900.86847250
76Acute myeloid leukemia_Homo sapiens_hsa052210.85229121
77Synaptic vesicle cycle_Homo sapiens_hsa047210.84462284
78Histidine metabolism_Homo sapiens_hsa003400.84368786
79Complement and coagulation cascades_Homo sapiens_hsa046100.80062404
80Taste transduction_Homo sapiens_hsa047420.78572613
81Tyrosine metabolism_Homo sapiens_hsa003500.74928993
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74030961
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73756981
84Cocaine addiction_Homo sapiens_hsa050300.70975311
85Prolactin signaling pathway_Homo sapiens_hsa049170.70933121
86Tryptophan metabolism_Homo sapiens_hsa003800.69886343
87Basal transcription factors_Homo sapiens_hsa030220.69737728
88Amphetamine addiction_Homo sapiens_hsa050310.69305981
89Phagosome_Homo sapiens_hsa041450.68006634
90Glutathione metabolism_Homo sapiens_hsa004800.67285156
91Dopaminergic synapse_Homo sapiens_hsa047280.65776789
92Asthma_Homo sapiens_hsa053100.64152702
93Arginine and proline metabolism_Homo sapiens_hsa003300.62356209
94Salivary secretion_Homo sapiens_hsa049700.61804299
95Metabolic pathways_Homo sapiens_hsa011000.60039667
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59772970
97Spliceosome_Homo sapiens_hsa030400.58468535
98Circadian entrainment_Homo sapiens_hsa047130.57371506
99Purine metabolism_Homo sapiens_hsa002300.57161197
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.56801151
101Sulfur metabolism_Homo sapiens_hsa009200.56525833
102Other glycan degradation_Homo sapiens_hsa005110.55690579
103Vitamin B6 metabolism_Homo sapiens_hsa007500.54771752
104Lysosome_Homo sapiens_hsa041420.53519860
105Mineral absorption_Homo sapiens_hsa049780.53441922
106Type I diabetes mellitus_Homo sapiens_hsa049400.53409450
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.53099718
108Renin secretion_Homo sapiens_hsa049240.53067481
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52753168
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51645578
111Apoptosis_Homo sapiens_hsa042100.50713243
112Cholinergic synapse_Homo sapiens_hsa047250.50641785
113Caffeine metabolism_Homo sapiens_hsa002320.50560005
114Long-term potentiation_Homo sapiens_hsa047200.49623400
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49574545
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.49452591
117Insulin resistance_Homo sapiens_hsa049310.47063783
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.46879623
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46337244
120Glycerolipid metabolism_Homo sapiens_hsa005610.45033464
121Phenylalanine metabolism_Homo sapiens_hsa003600.44503907
122Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44078107
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.43115160
124Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43055867
125Homologous recombination_Homo sapiens_hsa034400.41407671
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41319221
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41142988
128FoxO signaling pathway_Homo sapiens_hsa040680.40674861
129Pancreatic cancer_Homo sapiens_hsa052120.40601174
130Calcium signaling pathway_Homo sapiens_hsa040200.39659264
131Butanoate metabolism_Homo sapiens_hsa006500.37416609
132Non-homologous end-joining_Homo sapiens_hsa034500.37360203
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37208742
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.36295785
135Malaria_Homo sapiens_hsa051440.35459084
136Type II diabetes mellitus_Homo sapiens_hsa049300.35284567
137Gastric acid secretion_Homo sapiens_hsa049710.35029119
138Chemical carcinogenesis_Homo sapiens_hsa052040.34778907
139Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34625822
140RNA degradation_Homo sapiens_hsa030180.34011194
141VEGF signaling pathway_Homo sapiens_hsa043700.33807273
142Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33454832
143Vascular smooth muscle contraction_Homo sapiens_hsa042700.32995286
144Choline metabolism in cancer_Homo sapiens_hsa052310.32772908
145Retinol metabolism_Homo sapiens_hsa008300.32388675
146Ras signaling pathway_Homo sapiens_hsa040140.32100938
147Gap junction_Homo sapiens_hsa045400.31752879
148HTLV-I infection_Homo sapiens_hsa051660.31211038
149MAPK signaling pathway_Homo sapiens_hsa040100.31159201
150Non-small cell lung cancer_Homo sapiens_hsa052230.28781859
151Ovarian steroidogenesis_Homo sapiens_hsa049130.27335048
152Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26901330
153Olfactory transduction_Homo sapiens_hsa047400.26537246
154Epstein-Barr virus infection_Homo sapiens_hsa051690.25786654
155Glycerophospholipid metabolism_Homo sapiens_hsa005640.25388774
156Alcoholism_Homo sapiens_hsa050340.25274356
157Prion diseases_Homo sapiens_hsa050200.25227821
158Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24525662
159Amoebiasis_Homo sapiens_hsa051460.24523107
160Salmonella infection_Homo sapiens_hsa051320.23589028
161Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22843867
162NOD-like receptor signaling pathway_Homo sapiens_hsa046210.22698695
163Fanconi anemia pathway_Homo sapiens_hsa034600.22384052
164Pancreatic secretion_Homo sapiens_hsa049720.22047165
165Pertussis_Homo sapiens_hsa051330.21159830
166Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.20068466
167Renal cell carcinoma_Homo sapiens_hsa052110.19472613
168Folate biosynthesis_Homo sapiens_hsa007900.19225973
169Nucleotide excision repair_Homo sapiens_hsa034200.19000299

Most similar genes based on co-expression Upload to Enrichr

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