XAGE1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)6.69290580
2establishment of integrated proviral latency (GO:0075713)6.28939015
3establishment of viral latency (GO:0019043)5.87748519
4Golgi transport vesicle coating (GO:0048200)4.97077513
5COPI coating of Golgi vesicle (GO:0048205)4.97077513
6proteasome assembly (GO:0043248)4.74724258
7DNA unwinding involved in DNA replication (GO:0006268)4.60345751
8mitotic nuclear envelope reassembly (GO:0007084)4.52780079
9nuclear envelope reassembly (GO:0031468)4.52780079
10ribosome assembly (GO:0042255)4.47192196
11gonadal mesoderm development (GO:0007506)4.16893012
12formation of translation preinitiation complex (GO:0001731)4.04730186
13negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.99962742
14ribosomal large subunit biogenesis (GO:0042273)3.82965037
15positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.80667589
16negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.77153683
17maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.74113305
18protein retention in ER lumen (GO:0006621)3.71550189
19anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.70181715
20regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.69600636
21extracellular fibril organization (GO:0043206)3.66798254
22negative regulation of ligase activity (GO:0051352)3.64932103
23negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.64932103
24lipopolysaccharide biosynthetic process (GO:0009103)3.62524805
25regulation of mitotic spindle organization (GO:0060236)3.60540937
26muscle cell migration (GO:0014812)3.59460973
27galactose catabolic process (GO:0019388)3.51995067
28regulation of metalloenzyme activity (GO:0048552)3.51378341
29membrane raft organization (GO:0031579)3.50497562
30positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.48913693
31morphogenesis of an endothelium (GO:0003159)3.48841934
32endothelial tube morphogenesis (GO:0061154)3.48841934
33detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.47915659
34regulation of cellular amino acid metabolic process (GO:0006521)3.46370703
35telomere maintenance via semi-conservative replication (GO:0032201)3.45597813
36DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.37980222
37nucleobase-containing small molecule interconversion (GO:0015949)3.37283847
38signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.35043354
39intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.35043354
40deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.34785012
41positive regulation of ligase activity (GO:0051351)3.30349524
42negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.28365497
43signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.28150683
44signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.28150683
45signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.28150683
46response to gravity (GO:0009629)3.26250073
47signal transduction involved in DNA damage checkpoint (GO:0072422)3.26055538
48signal transduction involved in DNA integrity checkpoint (GO:0072401)3.26055538
49regulation of mitochondrial translation (GO:0070129)3.18974063
50signal transduction involved in cell cycle checkpoint (GO:0072395)3.17599011
51DNA strand elongation involved in DNA replication (GO:0006271)3.11404989
52regulation of spindle organization (GO:0090224)3.07527171
53antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.06479846
54DNA strand elongation (GO:0022616)3.05680910
55proline biosynthetic process (GO:0006561)3.05400418
56positive regulation of actin filament depolymerization (GO:0030836)3.05343739
57regulation of ubiquitin-protein transferase activity (GO:0051438)3.03911818
58AMP metabolic process (GO:0046033)3.02816637
59fibril organization (GO:0097435)3.01973828
60protein targeting to mitochondrion (GO:0006626)3.00479696
61mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.99436280
62negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.98724505
63mitotic chromosome condensation (GO:0007076)2.98666902
64mitotic sister chromatid segregation (GO:0000070)2.98567579
65GDP-mannose metabolic process (GO:0019673)2.93841704
66mitotic metaphase plate congression (GO:0007080)2.92313434
67positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.91993872
68regulation of ligase activity (GO:0051340)2.90226491
69lipopolysaccharide metabolic process (GO:0008653)2.88254805
70actin filament depolymerization (GO:0030042)2.87391660
71ribonucleoprotein complex biogenesis (GO:0022613)2.85788839
72transcription-coupled nucleotide-excision repair (GO:0006283)2.84356515
73antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.82073377
74ribosomal small subunit assembly (GO:0000028)2.79692130
75positive regulation of DNA-dependent DNA replication (GO:2000105)2.78976218
76regulation of translational fidelity (GO:0006450)2.78833998
77galactose metabolic process (GO:0006012)2.78450865
78telomere maintenance via recombination (GO:0000722)2.75334323
79detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.74535179
80cellular copper ion homeostasis (GO:0006878)2.73203465
81guanosine-containing compound biosynthetic process (GO:1901070)2.72248231
82ribosome biogenesis (GO:0042254)2.68279492
83mitotic recombination (GO:0006312)2.67641842
84ATP synthesis coupled proton transport (GO:0015986)2.67063586
85energy coupled proton transport, down electrochemical gradient (GO:0015985)2.67063586
86heterochromatin organization (GO:0070828)2.66780264
87establishment of protein localization to mitochondrion (GO:0072655)2.66648774
887-methylguanosine mRNA capping (GO:0006370)2.65058502
89mitotic nuclear envelope disassembly (GO:0007077)2.64235466
90protein localization to mitochondrion (GO:0070585)2.62829672
91glycolytic process (GO:0006096)2.61712685
92fibrinolysis (GO:0042730)2.59822104
93chaperone-mediated protein transport (GO:0072321)2.58204097
94metaphase plate congression (GO:0051310)2.58096970
95negative regulation of protein ubiquitination (GO:0031397)2.57743130
96heme biosynthetic process (GO:0006783)2.56553067
97regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.56512590
98RNA capping (GO:0036260)2.56285705
997-methylguanosine RNA capping (GO:0009452)2.56285705
100nucleoside transmembrane transport (GO:1901642)2.56105110

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.94416553
2E2F7_22180533_ChIP-Seq_HELA_Human3.51912235
3HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.17609422
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.06006959
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.05253053
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.98989545
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.87971618
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.85675866
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.79095380
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.77013150
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.67080812
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53133118
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.53046127
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.50034001
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.49777579
16DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.35442181
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.29594057
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.25151388
19DCP1A_22483619_ChIP-Seq_HELA_Human2.22417591
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.20914921
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.16988869
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.14685947
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.12198388
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.11207700
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.10921742
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09381673
27ZNF263_19887448_ChIP-Seq_K562_Human2.05313387
28XRN2_22483619_ChIP-Seq_HELA_Human2.04190763
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.00219423
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.97453498
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.94322104
32GABP_19822575_ChIP-Seq_HepG2_Human1.90711931
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.89149178
34ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.85648161
35AR_21909140_ChIP-Seq_LNCAP_Human1.74857343
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.71749357
37CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.67300406
38ELK1_19687146_ChIP-ChIP_HELA_Human1.63964462
39PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.63327421
40VDR_23849224_ChIP-Seq_CD4+_Human1.61269889
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.61257097
42TTF2_22483619_ChIP-Seq_HELA_Human1.59057975
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58410933
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57243118
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53317911
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51195097
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50888761
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.49858354
49CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.49779242
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.48776975
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45678262
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43441611
53TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43338452
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.42859945
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42690709
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.42393586
57CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.41381620
58FOXP3_21729870_ChIP-Seq_TREG_Human1.39459125
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36929114
60TFEB_21752829_ChIP-Seq_HELA_Human1.36421004
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36335523
62PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.36134285
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34644297
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34119629
65ATF3_27146783_Chip-Seq_COLON_Human1.30639695
66SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29679140
67KDM5A_27292631_Chip-Seq_BREAST_Human1.27946761
68ELK1_22589737_ChIP-Seq_MCF10A_Human1.27701902
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27191212
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26785012
71KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26420282
72DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.26352630
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25567732
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.25292195
75HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.24632188
76BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.23519184
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21303270
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21196843
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19413770
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18844578
81VDR_21846776_ChIP-Seq_THP-1_Human1.18208654
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17187105
83TBX5_21415370_ChIP-Seq_HL-1_Mouse1.15882092
84SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15631770
85E2F1_21310950_ChIP-Seq_MCF-7_Human1.12209109
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11909298
87ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10954805
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09962874
89SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09513921
90NCOR1_26117541_ChIP-Seq_K562_Human1.08761054
91STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07686565
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07684859
93CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05866221
94CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05571008
95SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.03942511
96SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.03942511
97SOX17_20123909_ChIP-Seq_XEN_Mouse1.03231396
98CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96249571
99TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94838976
100SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94166769

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003191_abnormal_cellular_cholesterol3.55170800
2MP0003123_paternal_imprinting3.54434403
3MP0002877_abnormal_melanocyte_morpholog3.35489460
4MP0003950_abnormal_plasma_membrane2.97502370
5MP0009697_abnormal_copulation2.75872905
6MP0003806_abnormal_nucleotide_metabolis2.72562844
7MP0004957_abnormal_blastocyst_morpholog2.68915787
8MP0003786_premature_aging2.68780499
9MP0003693_abnormal_embryo_hatching2.63913221
10MP0005058_abnormal_lysosome_morphology2.50933069
11MP0000750_abnormal_muscle_regeneration2.41757312
12MP0000751_myopathy2.36809358
13MP0003111_abnormal_nucleus_morphology2.28421499
14MP0008007_abnormal_cellular_replicative2.27138195
15MP0005257_abnormal_intraocular_pressure2.26240636
16MP0010030_abnormal_orbit_morphology2.24514367
17MP0000749_muscle_degeneration2.18788293
18MP0005451_abnormal_body_composition2.18444598
19MP0003077_abnormal_cell_cycle2.14410679
20MP0010094_abnormal_chromosome_stability2.11901202
21MP0008058_abnormal_DNA_repair2.09415651
22MP0003656_abnormal_erythrocyte_physiolo2.08813377
23MP0001853_heart_inflammation2.04632946
24MP0002332_abnormal_exercise_endurance2.03537755
25MP0008932_abnormal_embryonic_tissue2.00567489
26MP0004272_abnormal_basement_membrane1.96157745
27MP0005360_urolithiasis1.95878844
28MP0004147_increased_porphyrin_level1.89584092
29MP0005165_increased_susceptibility_to1.88878037
30MP0003186_abnormal_redox_activity1.74046049
31MP0003566_abnormal_cell_adhesion1.71578688
32MP0009840_abnormal_foam_cell1.71127025
33MP0000858_altered_metastatic_potential1.70834501
34MP0005083_abnormal_biliary_tract1.66242552
35MP0005330_cardiomyopathy1.64911486
36MP0001542_abnormal_bone_strength1.62971533
37MP0004510_myositis1.58737666
38MP0003315_abnormal_perineum_morphology1.58703761
39MP0000358_abnormal_cell_content/1.55435960
40MP0006036_abnormal_mitochondrial_physio1.55367287
41MP0003718_maternal_effect1.45267615
42MP0008775_abnormal_heart_ventricle1.41813643
43MP0000343_altered_response_to1.40939154
44MP0006035_abnormal_mitochondrial_morpho1.37515022
45MP0005408_hypopigmentation1.35074725
46MP0000350_abnormal_cell_proliferation1.32512092
47MP0002060_abnormal_skin_morphology1.30933802
48MP0000647_abnormal_sebaceous_gland1.28721976
49MP0005670_abnormal_white_adipose1.25877924
50MP0001730_embryonic_growth_arrest1.21369398
51MP0005464_abnormal_platelet_physiology1.20993233
52MP0003075_altered_response_to1.19878413
53MP0004233_abnormal_muscle_weight1.16000050
54MP0008995_early_reproductive_senescence1.15753854
55MP0001243_abnormal_dermal_layer1.11172729
56MP0000516_abnormal_urinary_system1.11089006
57MP0005367_renal/urinary_system_phenotyp1.11089006
58MP0002080_prenatal_lethality1.09166061
59MP0009780_abnormal_chondrocyte_physiolo1.07968886
60MP0005197_abnormal_uvea_morphology1.07861120
61MP0008260_abnormal_autophagy1.01835771
62MP0000313_abnormal_cell_death1.01559758
63MP0009333_abnormal_splenocyte_physiolog1.00290705
64MP0000747_muscle_weakness0.99841234
65MP0002019_abnormal_tumor_incidence0.99799748
66MP0005501_abnormal_skin_physiology0.97201286
67MP0005164_abnormal_response_to0.96643871
68MP0001697_abnormal_embryo_size0.93634819
69MP0001299_abnormal_eye_distance/0.87349718
70MP0003705_abnormal_hypodermis_morpholog0.86985726
71MP0003221_abnormal_cardiomyocyte_apopto0.85539577
72MP0001545_abnormal_hematopoietic_system0.85075504
73MP0005397_hematopoietic_system_phenotyp0.85075504
74MP0008438_abnormal_cutaneous_collagen0.84852629
75MP0003984_embryonic_growth_retardation0.82122025
76MP0005584_abnormal_enzyme/coenzyme_acti0.81661472
77MP0005384_cellular_phenotype0.80927937
78MP0001216_abnormal_epidermal_layer0.80271222
79MP0002269_muscular_atrophy0.77992562
80MP0002796_impaired_skin_barrier0.77190531
81MP0005380_embryogenesis_phenotype0.77173293
82MP0001672_abnormal_embryogenesis/_devel0.77173293
83MP0002088_abnormal_embryonic_growth/wei0.74837700
84MP0001881_abnormal_mammary_gland0.72598864
85MP0000609_abnormal_liver_physiology0.72587310
86MP0002177_abnormal_outer_ear0.71671363
87MP0000762_abnormal_tongue_morphology0.69785075
88MP0005621_abnormal_cell_physiology0.69590830
89MP0000759_abnormal_skeletal_muscle0.69524028
90MP0002972_abnormal_cardiac_muscle0.68852998
91MP0002210_abnormal_sex_determination0.66513233
92MP0003453_abnormal_keratinocyte_physiol0.66191138
93MP0005266_abnormal_metabolism0.65019144
94MP0004185_abnormal_adipocyte_glucose0.63805182
95MP0003943_abnormal_hepatobiliary_system0.63438728
96MP0002086_abnormal_extraembryonic_tissu0.63392547
97MP0005376_homeostasis/metabolism_phenot0.62099277
98MP0005023_abnormal_wound_healing0.61543595
99MP0003436_decreased_susceptibility_to0.61148597
100MP0008875_abnormal_xenobiotic_pharmacok0.60360879

Predicted human phenotypes

RankGene SetZ-score
1Reduced subcutaneous adipose tissue (HP:0003758)4.42781254
2Abnormal gallbladder physiology (HP:0012438)4.40062092
3Cholecystitis (HP:0001082)4.40062092
4Upper limb muscle weakness (HP:0003484)4.24934947
5Glucose intolerance (HP:0000833)4.00933725
6Amyloidosis (HP:0011034)3.72179145
7Increased serum pyruvate (HP:0003542)3.67008695
8Osteolytic defects of the phalanges of the hand (HP:0009771)3.60514688
9Osteolytic defects of the hand bones (HP:0009699)3.60514688
10Abnormality of glycolysis (HP:0004366)3.57750099
11Adrenal hypoplasia (HP:0000835)3.55636373
12Entropion (HP:0000621)3.43623183
13Premature rupture of membranes (HP:0001788)3.28093726
14Short nail (HP:0001799)3.14840763
15Abnormal mitochondria in muscle tissue (HP:0008316)3.14714239
16Acute necrotizing encephalopathy (HP:0006965)3.13245587
17Delayed CNS myelination (HP:0002188)2.99972601
18Hepatocellular necrosis (HP:0001404)2.99651340
19Rough bone trabeculation (HP:0100670)2.97768346
20Vertebral compression fractures (HP:0002953)2.90147766
21Reduced antithrombin III activity (HP:0001976)2.88724503
22Increased connective tissue (HP:0009025)2.87494064
23Abnormality of the distal phalanges of the toes (HP:0010182)2.86458722
24Type I transferrin isoform profile (HP:0003642)2.84077919
25Microglossia (HP:0000171)2.83033745
26Acute encephalopathy (HP:0006846)2.81139481
27Mitochondrial inheritance (HP:0001427)2.79562521
28Distal lower limb muscle weakness (HP:0009053)2.77064059
29Distal lower limb amyotrophy (HP:0008944)2.75581422
30Hypertensive crisis (HP:0100735)2.71277529
31Hepatic necrosis (HP:0002605)2.64363275
32Hand muscle atrophy (HP:0009130)2.62327779
33Orthostatic hypotension (HP:0001278)2.59361169
34Fatigue (HP:0012378)2.57171256
35Abnormal glucose tolerance (HP:0001952)2.53527954
36Shoulder girdle muscle weakness (HP:0003547)2.50752926
37Secondary amenorrhea (HP:0000869)2.49169301
38Increased CSF lactate (HP:0002490)2.46570253
39Myocardial infarction (HP:0001658)2.46411734
40Progressive macrocephaly (HP:0004481)2.45120717
41Insulin resistance (HP:0000855)2.42156731
42Exercise intolerance (HP:0003546)2.40654282
43Sparse eyelashes (HP:0000653)2.34846480
44Pelvic girdle muscle weakness (HP:0003749)2.34314365
45Abnormal autonomic nervous system physiology (HP:0012332)2.34032383
46Renal Fanconi syndrome (HP:0001994)2.33131642
47Abnormal platelet function (HP:0011869)2.30919705
48Impaired platelet aggregation (HP:0003540)2.30919705
49Abnormality of the umbilical cord (HP:0010881)2.30845304
50Upper limb amyotrophy (HP:0009129)2.29654900
51Distal upper limb amyotrophy (HP:0007149)2.29654900
52Aplasia/Hypoplasia of the sacrum (HP:0008517)2.27826854
53Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.27715574
54Abnormal protein N-linked glycosylation (HP:0012347)2.27715574
55Abnormal protein glycosylation (HP:0012346)2.27715574
56Abnormal glycosylation (HP:0012345)2.27715574
57Vascular calcification (HP:0004934)2.25331356
58Abnormal trabecular bone morphology (HP:0100671)2.22693779
59Increased serum lactate (HP:0002151)2.22052763
60Cholelithiasis (HP:0001081)2.20984386
61Decreased subcutaneous fat (HP:0001002)2.17648246
62Insomnia (HP:0100785)2.17307288
63Ileus (HP:0002595)2.16585255
64Increased hepatocellular lipid droplets (HP:0006565)2.15717426
65Abnormal hemoglobin (HP:0011902)2.13612377
66Limb-girdle muscle atrophy (HP:0003797)2.12742571
67Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.12046306
68Abnormality of alanine metabolism (HP:0010916)2.12046306
69Hyperalaninemia (HP:0003348)2.12046306
70Abnormality of the hip-girdle musculature (HP:0001445)2.11649373
71Abnormality of the musculature of the pelvis (HP:0001469)2.11649373
72Difficulty climbing stairs (HP:0003551)2.11508731
73Hepatosplenomegaly (HP:0001433)2.11110500
74Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.08728811
75Decreased activity of mitochondrial respiratory chain (HP:0008972)2.08728811
76Hepatocellular carcinoma (HP:0001402)2.01094748
77Progressive muscle weakness (HP:0003323)2.00005443
78Palpitations (HP:0001962)1.99950057
79Hyperbilirubinemia (HP:0002904)1.99726575
80Lactic acidosis (HP:0003128)1.99640172
81Spastic paraparesis (HP:0002313)1.99460344
82Achilles tendon contracture (HP:0001771)1.98989871
83Axonal loss (HP:0003447)1.97227763
84Increased intramyocellular lipid droplets (HP:0012240)1.96406170
85Proximal placement of thumb (HP:0009623)1.96203135
86Deviation of the thumb (HP:0009603)1.94805374
87Reticulocytosis (HP:0001923)1.94730696
88Hypokinesia (HP:0002375)1.93441559
89Hypergonadotropic hypogonadism (HP:0000815)1.93352105
90Abnormality of aromatic amino acid family metabolism (HP:0004338)1.92950203
91Conjugated hyperbilirubinemia (HP:0002908)1.91834893
92Cerebral edema (HP:0002181)1.91743715
93Abnormalities of placenta or umbilical cord (HP:0001194)1.91732335
94Testicular atrophy (HP:0000029)1.91368216
95Ureteral duplication (HP:0000073)1.89876575
96Abnormal gallbladder morphology (HP:0012437)1.89402013
97Male infertility (HP:0003251)1.88637806
98Onycholysis (HP:0001806)1.88338127
99Respiratory failure (HP:0002878)1.87243055
100Emotional lability (HP:0000712)1.86369059

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.27374663
2TESK24.24108772
3VRK24.23752799
4TESK14.11106233
5MST1R3.80081323
6EPHA23.55978214
7LIMK13.34408403
8BUB13.20103080
9IRAK32.77391507
10ARAF2.49879946
11LMTK22.20344131
12EIF2AK12.10293865
13NEK11.95985590
14SRPK11.89152952
15PAK41.85136329
16PIM21.81921405
17SCYL21.78773611
18ERN11.70453017
19STK101.69856387
20MET1.58852855
21MOS1.56728242
22TAOK21.44834233
23DAPK11.42224527
24CCNB11.41628174
25ERBB41.32187557
26MST41.31829051
27BRAF1.21408165
28BRSK11.19831896
29MAP2K71.19348478
30BCKDK1.13661999
31BMX1.09991755
32MAP3K121.08694014
33ABL21.07111602
34STK161.03549921
35MAPKAPK31.00369781
36ILK1.00096306
37CDK80.99510944
38ICK0.99093248
39PTK20.95277007
40VRK10.92916210
41EIF2AK30.92654808
42RAF10.90420349
43AURKA0.89718956
44PAK10.89207769
45LRRK20.84738152
46PRPF4B0.82686700
47MAP3K80.81860877
48PBK0.80339972
49TTK0.79552426
50PHKG10.78016862
51PHKG20.78016862
52CDC70.76015137
53TSSK60.74432878
54NEK20.74112448
55KDR0.69779796
56AURKB0.68723021
57PDK20.66923929
58WEE10.65548951
59PTK2B0.63247169
60CDK70.63235197
61PLK10.62455550
62NME10.62415552
63EIF2AK20.60971629
64RPS6KB20.57002228
65CLK10.56766360
66PRKCI0.56098260
67ERBB30.55827062
68CSNK1G30.54698932
69BRSK20.52462101
70PLK40.50978650
71TBK10.49928974
72PLK30.49260060
73CSNK1A1L0.44967735
74HIPK20.43843163
75SIK30.41233883
76CHEK20.39949625
77CSNK2A20.39569282
78CDK140.38640612
79TGFBR20.38332370
80CDK180.37122893
81EPHB10.36767963
82CDK11A0.36518217
83MYLK0.35733918
84BMPR20.35580726
85CDK150.35306493
86MAPKAPK20.34272976
87DAPK30.31996810
88MAP3K30.31076770
89MAP3K110.28288307
90MAP2K30.28288091
91MAP3K60.26482935
92CHEK10.25342347
93STK40.24196570
94ATR0.24023112
95RPS6KA50.22934757
96PTK60.22391691
97GRK70.22197781
98GRK50.21850527
99CSNK1G10.21351908
100EPHB20.21253736

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.82471682
2DNA replication_Homo sapiens_hsa030303.71376806
3Ribosome_Homo sapiens_hsa030102.96552919
4Mismatch repair_Homo sapiens_hsa034302.93412832
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.60360627
6Oxidative phosphorylation_Homo sapiens_hsa001902.50990428
7RNA polymerase_Homo sapiens_hsa030202.38426478
8Base excision repair_Homo sapiens_hsa034102.36281367
9Pyrimidine metabolism_Homo sapiens_hsa002402.32766334
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.31792409
11Nucleotide excision repair_Homo sapiens_hsa034202.25880638
12Parkinsons disease_Homo sapiens_hsa050122.16492366
13Sulfur relay system_Homo sapiens_hsa041222.14961415
14Fatty acid elongation_Homo sapiens_hsa000622.11591788
15Folate biosynthesis_Homo sapiens_hsa007902.05002704
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.02336190
17Biosynthesis of amino acids_Homo sapiens_hsa012302.01855573
18Huntingtons disease_Homo sapiens_hsa050161.92398405
19Pentose phosphate pathway_Homo sapiens_hsa000301.91254730
20Homologous recombination_Homo sapiens_hsa034401.88609785
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.78719121
22Alzheimers disease_Homo sapiens_hsa050101.69302794
23N-Glycan biosynthesis_Homo sapiens_hsa005101.66897699
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.63819073
25Galactose metabolism_Homo sapiens_hsa000521.59540544
26Carbon metabolism_Homo sapiens_hsa012001.58502620
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.57857714
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.54739844
29Fructose and mannose metabolism_Homo sapiens_hsa000511.54554722
30Pyruvate metabolism_Homo sapiens_hsa006201.53498845
31Spliceosome_Homo sapiens_hsa030401.52922654
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.51774686
33RNA transport_Homo sapiens_hsa030131.48572493
34Glutathione metabolism_Homo sapiens_hsa004801.47441859
35Other glycan degradation_Homo sapiens_hsa005111.28254044
36Cell cycle_Homo sapiens_hsa041101.19250831
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13574459
38Purine metabolism_Homo sapiens_hsa002301.12720780
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.11224900
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.09560982
41One carbon pool by folate_Homo sapiens_hsa006701.07888578
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01998438
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00931406
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.00020478
45Vibrio cholerae infection_Homo sapiens_hsa051100.99266340
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98950410
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98879216
48Protein export_Homo sapiens_hsa030600.92875604
49Sulfur metabolism_Homo sapiens_hsa009200.92390922
50Basal transcription factors_Homo sapiens_hsa030220.81505697
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79987225
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79297714
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.79257429
54Non-homologous end-joining_Homo sapiens_hsa034500.77947759
55Fanconi anemia pathway_Homo sapiens_hsa034600.76792121
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75493591
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.72057319
58Metabolic pathways_Homo sapiens_hsa011000.71302714
59Shigellosis_Homo sapiens_hsa051310.70024376
60Apoptosis_Homo sapiens_hsa042100.64190507
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.64094197
62Epstein-Barr virus infection_Homo sapiens_hsa051690.62721360
63Steroid biosynthesis_Homo sapiens_hsa001000.58153906
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56856812
65Cardiac muscle contraction_Homo sapiens_hsa042600.56304820
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54902970
67Salivary secretion_Homo sapiens_hsa049700.54848330
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.52684809
69RNA degradation_Homo sapiens_hsa030180.52602108
70Tyrosine metabolism_Homo sapiens_hsa003500.52073569
71Bladder cancer_Homo sapiens_hsa052190.49840449
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48394342
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46970001
74Pancreatic cancer_Homo sapiens_hsa052120.45569418
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45380620
76p53 signaling pathway_Homo sapiens_hsa041150.45241791
77Lysosome_Homo sapiens_hsa041420.42961680
78mRNA surveillance pathway_Homo sapiens_hsa030150.42121650
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41957592
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40632731
81Thyroid cancer_Homo sapiens_hsa052160.40022628
82Viral carcinogenesis_Homo sapiens_hsa052030.37584271
83Phenylalanine metabolism_Homo sapiens_hsa003600.35579289
84HIF-1 signaling pathway_Homo sapiens_hsa040660.34233135
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32664836
86Endocytosis_Homo sapiens_hsa041440.29009003
87Oocyte meiosis_Homo sapiens_hsa041140.26218910
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25472304
89Salmonella infection_Homo sapiens_hsa051320.24683412
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.24115672
91Arginine and proline metabolism_Homo sapiens_hsa003300.23761842
92Legionellosis_Homo sapiens_hsa051340.22537040
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.20868320
94Peroxisome_Homo sapiens_hsa041460.20747100
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.20656992
96Arginine biosynthesis_Homo sapiens_hsa002200.17793404
97Propanoate metabolism_Homo sapiens_hsa006400.17471847
98Mineral absorption_Homo sapiens_hsa049780.17279403
99HTLV-I infection_Homo sapiens_hsa051660.17198640
100Herpes simplex infection_Homo sapiens_hsa051680.16747200

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