XAGE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in normal testis, and in Ewing's sarcoma, rhabdomyosarcoma, a breast cancer and a germ cell tumor. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interferon-gamma secretion (GO:0072643)7.67650909
2pyrimidine-containing compound transmembrane transport (GO:0072531)7.29171138
3desmosome organization (GO:0002934)7.26525416
4keratinocyte development (GO:0003334)7.25899916
5estrogen biosynthetic process (GO:0006703)6.98630264
6vitamin transmembrane transport (GO:0035461)6.55160756
7cornea development in camera-type eye (GO:0061303)6.50949957
8bundle of His cell to Purkinje myocyte communication (GO:0086069)6.11814079
9receptor recycling (GO:0001881)5.98159471
10notochord development (GO:0030903)5.46965370
11branching involved in salivary gland morphogenesis (GO:0060445)5.12288712
12lung-associated mesenchyme development (GO:0060484)5.08270424
13folic acid transport (GO:0015884)4.90530366
14positive regulation of protein kinase C signaling (GO:0090037)4.68617960
15lateral sprouting from an epithelium (GO:0060601)4.50968401
16regulation of transforming growth factor beta2 production (GO:0032909)4.46434491
17keratinocyte proliferation (GO:0043616)4.42305195
18regulation of cell proliferation involved in kidney development (GO:1901722)4.41020454
19transepithelial transport (GO:0070633)4.25967850
20nucleoside transmembrane transport (GO:1901642)4.21076154
21vitamin D metabolic process (GO:0042359)4.16364693
22nephron tubule formation (GO:0072079)4.14546979
23establishment of apical/basal cell polarity (GO:0035089)4.10359122
24hippo signaling (GO:0035329)4.09688051
25L-fucose catabolic process (GO:0042355)3.99363307
26fucose catabolic process (GO:0019317)3.99363307
27L-fucose metabolic process (GO:0042354)3.99363307
28regulation of cellular respiration (GO:0043457)3.99035494
29intestinal epithelial cell development (GO:0060576)3.81626599
30regulation of integrin-mediated signaling pathway (GO:2001044)3.80097681
31cranial suture morphogenesis (GO:0060363)3.70785249
32sex differentiation (GO:0007548)3.65278036
33regulation of odontogenesis (GO:0042481)3.64998604
34regulation of hippo signaling (GO:0035330)3.61345978
35sphingosine metabolic process (GO:0006670)3.58057479
36positive regulation of odontogenesis (GO:0042482)3.57857602
37calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.55411373
38ncRNA 3-end processing (GO:0043628)3.50358781
39regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.49509090
40trophoblast giant cell differentiation (GO:0060707)3.48125682
41polarized epithelial cell differentiation (GO:0030859)3.47681377
42dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.47609895
43excretion (GO:0007588)3.46393366
44nucleoside transport (GO:0015858)3.42888290
45outflow tract septum morphogenesis (GO:0003148)3.41142271
46lung lobe morphogenesis (GO:0060463)3.39755614
47vitamin transport (GO:0051180)3.39557160
48exocrine pancreas development (GO:0031017)3.37863677
49urogenital system development (GO:0001655)3.33879909
50establishment of monopolar cell polarity (GO:0061162)3.29491261
51establishment or maintenance of monopolar cell polarity (GO:0061339)3.29491261
52negative regulation of Rho protein signal transduction (GO:0035024)3.27196550
53regulation of oxidative phosphorylation (GO:0002082)3.25772124
54endosome organization (GO:0007032)3.25348145
55trophectodermal cell differentiation (GO:0001829)3.24326404
56organelle membrane fusion (GO:0090174)3.24185559
57negative regulation of keratinocyte proliferation (GO:0010839)3.24128075
58bone trabecula formation (GO:0060346)3.22485750
59cellular response to gamma radiation (GO:0071480)3.19431853
60non-canonical Wnt signaling pathway (GO:0035567)3.17891300
61diol metabolic process (GO:0034311)3.15706480
62sphingoid metabolic process (GO:0046519)3.15053861
63fucose metabolic process (GO:0006004)3.14932879
64mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.11528607
65auditory receptor cell stereocilium organization (GO:0060088)3.11453378
66paraxial mesoderm development (GO:0048339)3.09499878
67G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.08413736
68establishment of epithelial cell polarity (GO:0090162)3.06845137
69cofactor transport (GO:0051181)3.05911007
70establishment of tissue polarity (GO:0007164)2.95743248
71establishment of planar polarity (GO:0001736)2.95743248
72cytoskeletal anchoring at plasma membrane (GO:0007016)2.94041681
73nitric oxide biosynthetic process (GO:0006809)2.93258963
74cell differentiation involved in embryonic placenta development (GO:0060706)2.91605666
75basic amino acid transport (GO:0015802)2.91559065
76positive regulation of hair cycle (GO:0042635)2.91089883
77positive regulation of hair follicle development (GO:0051798)2.91089883
78viral transcription (GO:0019083)2.90322431
79labyrinthine layer development (GO:0060711)2.90204514
80regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.89686775
81regulation of keratinocyte proliferation (GO:0010837)2.89448244
82oligosaccharide catabolic process (GO:0009313)2.89330790
83regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.85651264
84mitotic G2/M transition checkpoint (GO:0044818)2.85275686
85transferrin transport (GO:0033572)2.84892191
86L-ascorbic acid metabolic process (GO:0019852)2.82872929
87negative regulation of stem cell proliferation (GO:2000647)2.81285313
88response to follicle-stimulating hormone (GO:0032354)2.78860725
89positive regulation of meiotic cell cycle (GO:0051446)2.78333579
90lens fiber cell development (GO:0070307)2.76802249
91DNA methylation involved in gamete generation (GO:0043046)2.76035923
92positive regulation of hormone metabolic process (GO:0032352)2.74870788
93organ formation (GO:0048645)2.73537700
94negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.73501362
95mating behavior (GO:0007617)2.72149956
96protein autoprocessing (GO:0016540)2.72069651
97negative regulation of epidermal cell differentiation (GO:0045605)2.71437306
98definitive hemopoiesis (GO:0060216)2.71196217
99regulation of guanylate cyclase activity (GO:0031282)2.69872492
100one-carbon compound transport (GO:0019755)2.69662490

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF263_19887448_ChIP-Seq_K562_Human5.88770238
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human5.19869886
3ESR1_21235772_ChIP-Seq_MCF-7_Human4.76761554
4ESR2_21235772_ChIP-Seq_MCF-7_Human4.66005374
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.36690362
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.60080324
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.60080324
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.60080324
9AHR_22903824_ChIP-Seq_MCF-7_Human3.06478574
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.97242487
11CDX2_20551321_ChIP-Seq_CACO-2_Human2.83700864
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.68453991
13GATA4_25053715_ChIP-Seq_YYC3_Human2.61530250
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.57606685
15AR_21909140_ChIP-Seq_LNCAP_Human2.45529973
16ZNF217_24962896_ChIP-Seq_MCF-7_Human2.39599588
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.26639911
18ELF5_23300383_ChIP-Seq_T47D_Human2.10174718
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.07729399
20GATA3_24758297_ChIP-Seq_MCF-7_Human1.96649989
21ARNT_22903824_ChIP-Seq_MCF-7_Human1.95989977
22POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.93973079
23GATA6_25053715_ChIP-Seq_YYC3_Human1.93040178
24CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.80471923
25SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.71170752
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.70184746
27BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.68767549
28EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.68202778
29ESR1_20079471_ChIP-ChIP_T-47D_Human1.66109518
30PPAR_26484153_Chip-Seq_NCI-H1993_Human1.59574724
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.56209626
32MYC_18555785_ChIP-Seq_MESCs_Mouse1.55404928
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.46964851
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46441315
35HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.43843972
36TP63_17297297_ChIP-ChIP_HaCaT_Human1.42235919
37SALL4_18804426_ChIP-ChIP_XEN_Mouse1.41887172
38ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36030383
39RUNX1_27514584_Chip-Seq_MCF-7_Human1.35680257
40ERG_20517297_ChIP-Seq_VCAP_Human1.33827415
41HIF1A_21447827_ChIP-Seq_MCF-7_Human1.32555145
42PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.31117542
43ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29836789
44FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24563172
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.18912501
46KLF5_25053715_ChIP-Seq_YYC3_Human1.17938027
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.16632351
48SOX2_20726797_ChIP-Seq_SW620_Human1.15327342
49GATA1_22025678_ChIP-Seq_K562_Human1.14659742
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13705219
51P63_26484246_Chip-Seq_KERATINOCYTES_Human1.11840854
52RACK7_27058665_Chip-Seq_MCF-7_Human1.10894934
53NANOG_18692474_ChIP-Seq_MEFs_Mouse1.10016714
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09317005
55SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07312713
56GATA1_26923725_Chip-Seq_HPCs_Mouse1.07243355
57EGR1_19032775_ChIP-ChIP_M12_Human1.04762281
58EOMES_21245162_ChIP-Seq_HESCs_Human1.03961717
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02772622
60ISL1_27105846_Chip-Seq_CPCs_Mouse0.97613008
61KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95544140
62VDR_22108803_ChIP-Seq_LS180_Human0.91819474
63TAF15_26573619_Chip-Seq_HEK293_Human0.91126274
64ERG_21242973_ChIP-ChIP_JURKAT_Human0.91060294
65MYC_19829295_ChIP-Seq_ESCs_Human0.89319448
66TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.89237520
67SOX9_24532713_ChIP-Seq_HFSC_Mouse0.88003952
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.87570327
69CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.87149396
70SMAD3_21741376_ChIP-Seq_HESCs_Human0.86931651
71NANOG_18692474_ChIP-Seq_MESCs_Mouse0.86370949
72TP63_23658742_ChIP-Seq_EP156T_Human0.86212357
73PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84858348
74TP53_20018659_ChIP-ChIP_R1E_Mouse0.83812464
75PPARA_22158963_ChIP-Seq_LIVER_Mouse0.82707556
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.81469591
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81191042
78STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81136032
79JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.81104015
80RXR_22158963_ChIP-Seq_LIVER_Mouse0.80928464
81TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80233266
82EP300_21415370_ChIP-Seq_HL-1_Mouse0.78038725
83STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.77505797
84NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.77342221
85GATA1_19941826_ChIP-Seq_K562_Human0.77209232
86ATF3_27146783_Chip-Seq_COLON_Human0.76599512
87SOX2_27498859_Chip-Seq_STOMACH_Mouse0.76196343
88TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.75543657
89TET1_21451524_ChIP-Seq_MESCs_Mouse0.75386537
90ETV2_25802403_ChIP-Seq_MESCs_Mouse0.75301994
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.73404058
92FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.72136882
93STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.71705911
94SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.71381259
95SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.71381259
96FOXO3_23340844_ChIP-Seq_DLD1_Human0.70916247
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.69730818
98TP63_22573176_ChIP-Seq_HFKS_Human0.68959679
99P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.68308746
100TET1_21490601_ChIP-Seq_MESCs_Mouse0.67959427

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology7.74364070
2MP0005377_hearing/vestibular/ear_phenot7.74364070
3MP0004264_abnormal_extraembryonic_tissu4.93444371
4MP0000383_abnormal_hair_follicle4.13726673
5MP0002098_abnormal_vibrissa_morphology3.54662699
6MP0010678_abnormal_skin_adnexa3.46007662
7MP0000647_abnormal_sebaceous_gland3.39399653
8MP0010234_abnormal_vibrissa_follicle3.20727221
9MP0001346_abnormal_lacrimal_gland3.02452631
10MP0003941_abnormal_skin_development2.61556634
11MP0002796_impaired_skin_barrier2.19807853
12MP0000377_abnormal_hair_follicle2.13291505
13MP0005646_abnormal_pituitary_gland2.11251652
14MP0005248_abnormal_Harderian_gland1.96375077
15MP0000427_abnormal_hair_cycle1.91683147
16MP0003693_abnormal_embryo_hatching1.86997313
17MP0003567_abnormal_fetal_cardiomyocyte1.84497849
18MP0003879_abnormal_hair_cell1.79975728
19MP0000566_synostosis1.73238841
20MP0005367_renal/urinary_system_phenotyp1.68295230
21MP0000516_abnormal_urinary_system1.68295230
22MP0004782_abnormal_surfactant_physiolog1.64139989
23MP0003806_abnormal_nucleotide_metabolis1.53348620
24MP0004019_abnormal_vitamin_homeostasis1.52596632
25MP0001485_abnormal_pinna_reflex1.48688882
26MP0002876_abnormal_thyroid_physiology1.45189294
27MP0008775_abnormal_heart_ventricle1.39305419
28MP0005408_hypopigmentation1.34703685
29MP0005501_abnormal_skin_physiology1.33497733
30MP0003938_abnormal_ear_development1.26516677
31MP0005076_abnormal_cell_differentiation1.25487925
32MP0002938_white_spotting1.25430996
33MP0000537_abnormal_urethra_morphology1.18924971
34MP0001216_abnormal_epidermal_layer1.16979029
35MP0000579_abnormal_nail_morphology1.13293092
36MP0008872_abnormal_physiological_respon1.12753917
37MP0003123_paternal_imprinting1.09466912
38MP0003718_maternal_effect1.08018202
39MP0010352_gastrointestinal_tract_polyps1.07211338
40MP0003191_abnormal_cellular_cholesterol1.05602878
41MP0003119_abnormal_digestive_system1.03523966
42MP0002127_abnormal_cardiovascular_syste1.00927364
43MP0004957_abnormal_blastocyst_morpholog1.00761122
44MP0002254_reproductive_system_inflammat1.00175320
45MP0003942_abnormal_urinary_system0.97837816
46MP0010771_integument_phenotype0.97037874
47MP0001340_abnormal_eyelid_morphology0.95237514
48MP0009697_abnormal_copulation0.94836805
49MP0002697_abnormal_eye_size0.94551816
50MP0003943_abnormal_hepatobiliary_system0.94267268
51MP0002160_abnormal_reproductive_system0.90130267
52MP0000367_abnormal_coat/_hair0.89318381
53MP0003936_abnormal_reproductive_system0.88611654
54MP0005636_abnormal_mineral_homeostasis0.87328854
55MP0004147_increased_porphyrin_level0.87133654
56MP0001293_anophthalmia0.86005889
57MP0009703_decreased_birth_body0.85644618
58MP0003638_abnormal_response/metabolism_0.85384077
59MP0001756_abnormal_urination0.85023353
60MP0000762_abnormal_tongue_morphology0.84965091
61MP0001958_emphysema0.83724447
62MP0000026_abnormal_inner_ear0.83223947
63MP0005023_abnormal_wound_healing0.83113123
64MP0006138_congestive_heart_failure0.83096246
65MP0003566_abnormal_cell_adhesion0.82311652
66MP0001764_abnormal_homeostasis0.78164928
67MP0001873_stomach_inflammation0.76942062
68MP0003385_abnormal_body_wall0.76605827
69MP0005058_abnormal_lysosome_morphology0.74458640
70MP0005389_reproductive_system_phenotype0.74438486
71MP0001177_atelectasis0.74239399
72MP0009643_abnormal_urine_homeostasis0.73841551
73MP0008875_abnormal_xenobiotic_pharmacok0.65833684
74MP0004084_abnormal_cardiac_muscle0.64665977
75MP0003453_abnormal_keratinocyte_physiol0.64595481
76MP0003122_maternal_imprinting0.64406259
77MP0003937_abnormal_limbs/digits/tail_de0.63640935
78MP0002136_abnormal_kidney_physiology0.63544028
79MP0004742_abnormal_vestibular_system0.63284397
80MP0002111_abnormal_tail_morphology0.62987807
81MP0000003_abnormal_adipose_tissue0.62911163
82MP0003935_abnormal_craniofacial_develop0.62002153
83MP0000639_abnormal_adrenal_gland0.60928439
84MP0002075_abnormal_coat/hair_pigmentati0.60633150
85MP0009053_abnormal_anal_canal0.59533240
86MP0009379_abnormal_foot_pigmentation0.59531167
87MP0005360_urolithiasis0.58680350
88MP0009931_abnormal_skin_appearance0.58564919
89MP0003195_calcinosis0.57867088
90MP0001697_abnormal_embryo_size0.56158139
91MP0005257_abnormal_intraocular_pressure0.56155524
92MP0005075_abnormal_melanosome_morpholog0.56143240
93MP0004233_abnormal_muscle_weight0.54477323
94MP0004197_abnormal_fetal_growth/weight/0.54024054
95MP0009672_abnormal_birth_weight0.51975307
96MP0005332_abnormal_amino_acid0.51726337
97MP0002085_abnormal_embryonic_tissue0.51509247
98MP0001765_abnormal_ion_homeostasis0.51218664
99MP0001879_abnormal_lymphatic_vessel0.50274896
100MP0001243_abnormal_dermal_layer0.49543741

Predicted human phenotypes

RankGene SetZ-score
1Proximal tubulopathy (HP:0000114)5.35891044
2Hypomagnesemia (HP:0002917)5.02268375
3Abnormality of dental color (HP:0011073)4.97574837
4Bilateral sensorineural hearing impairment (HP:0008619)4.88460995
5Tetany (HP:0001281)4.79857890
6Cone-rod dystrophy (HP:0000548)4.38763428
7Bicornuate uterus (HP:0000813)4.29540402
8Abnormality of magnesium homeostasis (HP:0004921)4.16537318
9Amelogenesis imperfecta (HP:0000705)4.00651685
10Right ventricular cardiomyopathy (HP:0011663)3.98092052
11Increased circulating renin level (HP:0000848)3.90791180
12Absent eyebrow (HP:0002223)3.85937163
13Renal tubular acidosis (HP:0001947)3.80643335
14Tubular atrophy (HP:0000092)3.71599646
15Morphological abnormality of the middle ear (HP:0008609)3.50586404
16Abnormality of the lacrimal duct (HP:0011481)3.39831763
17Paralysis (HP:0003470)3.20268745
18Absent eyelashes (HP:0000561)3.14109245
19Recurrent corneal erosions (HP:0000495)3.08138354
20Tongue fasciculations (HP:0001308)3.06320212
21Abnormal auditory evoked potentials (HP:0006958)3.05474074
22Partial agenesis of the corpus callosum (HP:0001338)3.03278002
23Bilateral microphthalmos (HP:0007633)3.03256085
24Delayed epiphyseal ossification (HP:0002663)2.95033930
25High anterior hairline (HP:0009890)2.93727025
26Concave nail (HP:0001598)2.90023329
27Vacuolated lymphocytes (HP:0001922)2.88849555
28Osteomalacia (HP:0002749)2.84304603
29Abnormality of the parietal bone (HP:0002696)2.81901551
30Patent foramen ovale (HP:0001655)2.81786598
31Asymmetry of the thorax (HP:0001555)2.81776443
32Abnormality of the nasolacrimal system (HP:0000614)2.80900549
33Renal tubular dysfunction (HP:0000124)2.76791151
34Muscle fibrillation (HP:0010546)2.76524696
35Myelomeningocele (HP:0002475)2.73432223
36Polydipsia (HP:0001959)2.73223977
37Abnormal drinking behavior (HP:0030082)2.73223977
38Cerebellar dysplasia (HP:0007033)2.71471522
39Hypoplasia of the iris (HP:0007676)2.59164767
40Hyperphosphaturia (HP:0003109)2.53652101
41Woolly hair (HP:0002224)2.51813933
42Lip pit (HP:0100267)2.50055645
43Choanal stenosis (HP:0000452)2.45637463
44Nasolacrimal duct obstruction (HP:0000579)2.41792616
45Stenosis of the external auditory canal (HP:0000402)2.41044296
46Severe Myopia (HP:0011003)2.41040137
47Aplasia cutis congenita (HP:0001057)2.40580435
48Hypokalemic alkalosis (HP:0001949)2.36891887
49Hypophosphatemic rickets (HP:0004912)2.35312548
50Increased corneal curvature (HP:0100692)2.34082508
51Keratoconus (HP:0000563)2.34082508
52Curly hair (HP:0002212)2.32966568
53Widely patent fontanelles and sutures (HP:0004492)2.31818029
54Abnormality of methionine metabolism (HP:0010901)2.30804773
55Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.30290793
56Decreased activity of mitochondrial respiratory chain (HP:0008972)2.30290793
57Split foot (HP:0001839)2.29914034
58Abnormal urine phosphate concentration (HP:0012599)2.26918640
59Congenital ichthyosiform erythroderma (HP:0007431)2.18704565
60Entropion (HP:0000621)2.18116665
61Unilateral renal agenesis (HP:0000122)2.17980912
62Megaloblastic anemia (HP:0001889)2.17914650
63Mesangial abnormality (HP:0001966)2.15983222
64Pili torti (HP:0003777)2.14274157
65Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.12805814
66Abolished electroretinogram (ERG) (HP:0000550)2.12305978
67Abnormality of the salivary glands (HP:0010286)2.11572324
68Hypokinesia (HP:0002375)2.10857561
69Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.09919364
70Short 1st metacarpal (HP:0010034)2.09919364
71Retinal atrophy (HP:0001105)2.09468184
72Anhidrosis (HP:0000970)2.08507384
73Nephrocalcinosis (HP:0000121)2.08353869
74Fused cervical vertebrae (HP:0002949)2.03874540
75Fragile nails (HP:0001808)2.03753295
76Wide intermamillary distance (HP:0006610)2.03499125
77Absent hair (HP:0002298)2.01951469
78Cutaneous finger syndactyly (HP:0010554)2.00824024
79Adrenal hypoplasia (HP:0000835)1.98128406
80Abnormality of aspartate family amino acid metabolism (HP:0010899)1.97662789
81Broad nasal tip (HP:0000455)1.97234910
82Abnormal pancreas size (HP:0012094)1.97117925
83Aplasia of the musculature (HP:0100854)1.95088066
84Glycosuria (HP:0003076)1.94727917
85Abnormality of urine glucose concentration (HP:0011016)1.94727917
86Abnormality of the 1st metacarpal (HP:0010009)1.94334820
87Bell-shaped thorax (HP:0001591)1.93634448
88Anophthalmia (HP:0000528)1.92391368
89Abnormality of renin-angiotensin system (HP:0000847)1.90674591
90Intrahepatic cholestasis (HP:0001406)1.90204461
91Chorioretinal atrophy (HP:0000533)1.89570456
92Poikiloderma (HP:0001029)1.88079851
93Cupped ear (HP:0000378)1.82713422
94Bifid tongue (HP:0010297)1.82107395
95Polyuria (HP:0000103)1.79979931
96Abnormality of monocarboxylic acid metabolism (HP:0010996)1.79934650
97Alopecia of scalp (HP:0002293)1.79568181
98Omphalocele (HP:0001539)1.77801608
99Coarctation of aorta (HP:0001680)1.77510647
100Renal cortical cysts (HP:0000803)1.73171899

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS16.30076359
2STK396.13281188
3OXSR14.94577624
4WNK44.26719164
5MST43.87428092
6NME13.61563739
7STK38L3.60015867
8LATS23.57084523
9EPHA23.24732975
10MAP3K133.06391436
11PASK2.39645700
12PIK3CA2.18851583
13MET1.75108711
14STK381.70931843
15EIF2AK31.64679300
16MAP3K71.54197451
17STK31.52798900
18FGFR21.46532798
19NUAK11.42087610
20NME21.38840771
21TNIK1.36260678
22PLK41.33727073
23FGR1.19367921
24PBK1.13459009
25TLK11.01321860
26MAP3K141.01294376
27DAPK20.99246253
28FER0.97607472
29MATK0.97329598
30MST1R0.94450017
31PAK40.93625613
32PDK20.86139856
33ICK0.85840930
34CDK190.82660316
35RPS6KA40.81861337
36ABL20.79096712
37RPS6KB20.77691741
38LIMK10.74387130
39MAPKAPK30.62646721
40PRKG20.60837501
41MAP2K60.58474295
42TRIM280.56672122
43TESK10.55955429
44CHUK0.52791704
45GRK10.51523851
46AKT30.49207987
47DAPK30.47800576
48PRKAA20.47403115
49STK240.45802160
50ILK0.41853411
51DAPK10.40572362
52TRPM70.40147082
53BCR0.36863924
54RPS6KA60.36439098
55PLK10.36341317
56MAP3K120.36284249
57AKT20.35703385
58ERBB30.35470635
59ADRBK20.34548501
60RPS6KL10.33784205
61RPS6KC10.33784205
62MAP2K10.33355467
63TGFBR10.32627096
64MYLK0.32033118
65PTK60.31991374
66STK100.31722791
67ABL10.30956883
68AURKB0.30302731
69EIF2AK10.29979891
70TAOK20.29678440
71STK160.27605767
72FGFR10.26688530
73STK110.25618922
74PRKD10.25117797
75PLK20.24768107
76ACVR1B0.24254472
77CAMK2G0.24130111
78WEE10.24047021
79CDK120.23836587
80IKBKB0.23790253
81NEK20.23592033
82PRKCI0.21962202
83BMPR1B0.21827873
84ROCK20.20768154
85EGFR0.20514788
86PKN20.19620573
87CSNK1E0.18982125
88PRKCA0.18967363
89DDR20.18891882
90SRC0.18008587
91BCKDK0.17396637
92CSNK1A10.17073704
93CHEK10.16791219
94LRRK20.15752372
95ADRBK10.15317108
96ZAP700.15071363
97FRK0.14728465
98PAK30.14671533
99ERBB20.14331472
100MAPKAPK50.14153449

Predicted pathways (KEGG)

RankGene SetZ-score
1Collecting duct acid secretion_Homo sapiens_hsa049665.23456906
2Folate biosynthesis_Homo sapiens_hsa007903.62858504
3Vitamin digestion and absorption_Homo sapiens_hsa049773.21555420
4Ribosome_Homo sapiens_hsa030102.98136714
5Steroid hormone biosynthesis_Homo sapiens_hsa001402.86535174
6Hedgehog signaling pathway_Homo sapiens_hsa043402.78676762
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.70881911
8Vibrio cholerae infection_Homo sapiens_hsa051102.63034807
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.39951926
10Basal cell carcinoma_Homo sapiens_hsa052172.31969016
11Oxidative phosphorylation_Homo sapiens_hsa001902.30570316
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.21664223
13Ovarian steroidogenesis_Homo sapiens_hsa049132.19457675
14One carbon pool by folate_Homo sapiens_hsa006702.14635584
15Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051202.10436037
16Hippo signaling pathway_Homo sapiens_hsa043901.93860193
17Sphingolipid metabolism_Homo sapiens_hsa006001.79355478
18Tight junction_Homo sapiens_hsa045301.70715013
19Ether lipid metabolism_Homo sapiens_hsa005651.69957573
20Mineral absorption_Homo sapiens_hsa049781.62398650
21Synaptic vesicle cycle_Homo sapiens_hsa047211.49846258
22Other glycan degradation_Homo sapiens_hsa005111.49668291
23Nicotine addiction_Homo sapiens_hsa050331.40464322
24Peroxisome_Homo sapiens_hsa041461.33227202
25Basal transcription factors_Homo sapiens_hsa030221.30661277
26Caffeine metabolism_Homo sapiens_hsa002321.28355900
27ECM-receptor interaction_Homo sapiens_hsa045121.26778875
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21526025
29Homologous recombination_Homo sapiens_hsa034401.21202868
30Sulfur relay system_Homo sapiens_hsa041221.17178337
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09836967
32Linoleic acid metabolism_Homo sapiens_hsa005911.01561753
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97054358
34p53 signaling pathway_Homo sapiens_hsa041150.96204819
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93991958
36Nucleotide excision repair_Homo sapiens_hsa034200.93832620
37Fatty acid elongation_Homo sapiens_hsa000620.92183222
38Renal cell carcinoma_Homo sapiens_hsa052110.89024416
39Arginine biosynthesis_Homo sapiens_hsa002200.89011285
40Adherens junction_Homo sapiens_hsa045200.88935642
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85684094
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84859874
43Tryptophan metabolism_Homo sapiens_hsa003800.82230877
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80571506
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80288193
46Wnt signaling pathway_Homo sapiens_hsa043100.73622057
47Retinol metabolism_Homo sapiens_hsa008300.72194191
48Arginine and proline metabolism_Homo sapiens_hsa003300.72061895
49Endocytosis_Homo sapiens_hsa041440.70934420
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69979511
51Huntingtons disease_Homo sapiens_hsa050160.69344003
52Melanogenesis_Homo sapiens_hsa049160.68900998
53RNA transport_Homo sapiens_hsa030130.68792765
54Spliceosome_Homo sapiens_hsa030400.68137861
55Metabolic pathways_Homo sapiens_hsa011000.67107635
56Proteoglycans in cancer_Homo sapiens_hsa052050.65730363
57Chemical carcinogenesis_Homo sapiens_hsa052040.64673691
58Small cell lung cancer_Homo sapiens_hsa052220.63434218
59Steroid biosynthesis_Homo sapiens_hsa001000.63413360
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62776833
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62527166
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61813953
63Protein digestion and absorption_Homo sapiens_hsa049740.61002096
64TGF-beta signaling pathway_Homo sapiens_hsa043500.57898868
65Pathways in cancer_Homo sapiens_hsa052000.57884944
66Renin-angiotensin system_Homo sapiens_hsa046140.57481832
67mRNA surveillance pathway_Homo sapiens_hsa030150.56409076
68Galactose metabolism_Homo sapiens_hsa000520.54999430
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.53732001
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52665601
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52557818
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51839735
73Parkinsons disease_Homo sapiens_hsa050120.51579614
74Glutathione metabolism_Homo sapiens_hsa004800.47808094
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.47496721
76N-Glycan biosynthesis_Homo sapiens_hsa005100.45332079
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.44924016
78Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44309229
79Ras signaling pathway_Homo sapiens_hsa040140.43150397
80Lysosome_Homo sapiens_hsa041420.43118800
81Non-homologous end-joining_Homo sapiens_hsa034500.42713761
82Alzheimers disease_Homo sapiens_hsa050100.42576337
83RNA degradation_Homo sapiens_hsa030180.41833683
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41736639
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.41408770
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40398601
87Focal adhesion_Homo sapiens_hsa045100.38472702
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35409325
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32716847
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.32298978
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32207917
92PI3K-Akt signaling pathway_Homo sapiens_hsa041510.32001867
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31941016
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31860581
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31457762
96Thyroid hormone synthesis_Homo sapiens_hsa049180.31311714
97ABC transporters_Homo sapiens_hsa020100.31171876
98Arachidonic acid metabolism_Homo sapiens_hsa005900.30405217
99Axon guidance_Homo sapiens_hsa043600.30346462
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.29244143

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