XBP1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)7.56678665
2neutrophil activation involved in immune response (GO:0002283)5.27009431
3negative regulation of telomere maintenance (GO:0032205)5.23989853
4regulation of pigment cell differentiation (GO:0050932)5.13270269
5positive regulation of male gonad development (GO:2000020)5.05845884
6positive regulation of developmental pigmentation (GO:0048087)4.95139983
7receptor recycling (GO:0001881)4.83440349
8proteasome assembly (GO:0043248)4.76414695
9regulation of helicase activity (GO:0051095)4.75350375
10nonmotile primary cilium assembly (GO:0035058)4.75067463
11regulation of female gonad development (GO:2000194)4.64961673
12peptidyl-histidine modification (GO:0018202)4.62894354
13negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.61724166
14positive regulation of cell size (GO:0045793)4.58155047
15regulation of male gonad development (GO:2000018)4.45107416
16regulation of nuclear cell cycle DNA replication (GO:0033262)4.37591137
17regulation of telomere maintenance (GO:0032204)4.30285036
18substrate-dependent cell migration (GO:0006929)4.22121976
19histone H3-K36 demethylation (GO:0070544)4.18746725
20detection of molecule of bacterial origin (GO:0032490)4.12956820
21negative regulation of interleukin-17 production (GO:0032700)4.01845342
22spliceosomal complex assembly (GO:0000245)3.96500254
23membrane budding (GO:0006900)3.95352346
24positive regulation of fibroblast migration (GO:0010763)3.88537040
25response to UV-B (GO:0010224)3.87722780
26positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.66677756
27centriole replication (GO:0007099)3.64607043
28cullin deneddylation (GO:0010388)3.53191232
29negative regulation of meiosis (GO:0045835)3.37880023
30positive regulation of mitochondrial fission (GO:0090141)3.37429478
31negative regulation of macroautophagy (GO:0016242)3.31766653
32pantothenate metabolic process (GO:0015939)3.30475369
33intestinal epithelial cell development (GO:0060576)3.29185795
34negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.27895104
35one-carbon compound transport (GO:0019755)3.25229025
36neuron projection extension involved in neuron projection guidance (GO:1902284)3.21198337
37axon extension involved in axon guidance (GO:0048846)3.21198337
38neutrophil mediated immunity (GO:0002446)3.20797065
39negative regulation of T cell receptor signaling pathway (GO:0050860)3.20250383
40interferon-gamma production (GO:0032609)3.19894153
41negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.17517398
42negative regulation of DNA-dependent DNA replication (GO:2000104)3.16157407
43establishment of protein localization to Golgi (GO:0072600)3.15030807
44histone H2A monoubiquitination (GO:0035518)3.14011345
45protein deneddylation (GO:0000338)3.13961549
46telomere maintenance via telomerase (GO:0007004)3.11997084
47regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.09521197
48retrograde transport, vesicle recycling within Golgi (GO:0000301)3.09497167
49neutrophil activation (GO:0042119)3.07617495
50regulation of T-helper 2 cell differentiation (GO:0045628)3.07151642
51replication fork processing (GO:0031297)3.06838544
52regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.05949205
53positive regulation of granulocyte differentiation (GO:0030854)3.05653591
54regulation of chromatin silencing (GO:0031935)3.01095618
55seminiferous tubule development (GO:0072520)3.00219019
56protein prenylation (GO:0018342)2.99755152
57prenylation (GO:0097354)2.99755152
58protein targeting to Golgi (GO:0000042)2.96476469
59signal peptide processing (GO:0006465)2.96426969
60protein neddylation (GO:0045116)2.96085720
61diaphragm development (GO:0060539)2.95123118
62positive regulation of response to biotic stimulus (GO:0002833)2.93397884
63mitochondrial DNA replication (GO:0006264)2.90540825
64olfactory bulb development (GO:0021772)2.90090275
65regulation of gene expression by genetic imprinting (GO:0006349)2.90071902
66positive regulation of steroid hormone secretion (GO:2000833)2.89772764
67ganglion development (GO:0061548)2.89092820
68positive regulation of toll-like receptor signaling pathway (GO:0034123)2.86948304
69photoreceptor cell maintenance (GO:0045494)2.83865392
70RNA-dependent DNA replication (GO:0006278)2.83319963
71skeletal muscle organ development (GO:0060538)2.82497598
72positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.81905216
73regulation of mitochondrial fission (GO:0090140)2.79405930
74myeloid leukocyte mediated immunity (GO:0002444)2.79189875
75regulation of telomere maintenance via telomerase (GO:0032210)2.78828189
76regulation of interleukin-17 production (GO:0032660)2.78375961
77negative regulation of axon guidance (GO:1902668)2.77152385
78protein K11-linked deubiquitination (GO:0035871)2.75630651
79positive regulation of mast cell activation involved in immune response (GO:0033008)2.74795828
80positive regulation of mast cell degranulation (GO:0043306)2.74795828
81negative regulation of chemokine production (GO:0032682)2.74298494
82dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.73358710
83melanosome transport (GO:0032402)2.71951026
84establishment of melanosome localization (GO:0032401)2.71682481
85pyrimidine nucleobase catabolic process (GO:0006208)2.71181239
86granulocyte activation (GO:0036230)2.71005364
87maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.70917166
88negative regulation of DNA recombination (GO:0045910)2.70661255
89cellular response to leptin stimulus (GO:0044320)2.70021494
90regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.67650595
91negative regulation of heart rate (GO:0010459)2.67208221
92positive regulation of heat generation (GO:0031652)2.67177438
93S-adenosylmethionine metabolic process (GO:0046500)2.66417024
94pericardium development (GO:0060039)2.66291423
95protein heterotetramerization (GO:0051290)2.65892149
96regulation of heat generation (GO:0031650)2.65132037
97B cell mediated immunity (GO:0019724)2.64607938
98regulation of T cell receptor signaling pathway (GO:0050856)2.63414636
99histone H2A ubiquitination (GO:0033522)2.62910967
100histone mRNA metabolic process (GO:0008334)2.61390342

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.12033206
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.11566144
3POU3F2_20337985_ChIP-ChIP_501MEL_Human3.06414927
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.90385991
5IGF1R_20145208_ChIP-Seq_DFB_Human2.79256615
6FUS_26573619_Chip-Seq_HEK293_Human2.72698078
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.61684792
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.61590931
9ELK1_19687146_ChIP-ChIP_HELA_Human2.57614392
10TAF15_26573619_Chip-Seq_HEK293_Human2.42637760
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.27924313
12VDR_23849224_ChIP-Seq_CD4+_Human2.24646887
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.23735081
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.21811682
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.20302351
16IRF1_19129219_ChIP-ChIP_H3396_Human2.11978701
17AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.10950554
18ER_23166858_ChIP-Seq_MCF-7_Human2.03230059
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.00631541
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.98647589
21GABP_17652178_ChIP-ChIP_JURKAT_Human1.97193198
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86912420
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.81130808
24EWS_26573619_Chip-Seq_HEK293_Human1.80498256
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.79232745
26MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.74481840
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65181161
28SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64994753
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62775163
30MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.59791357
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58883446
32P300_19829295_ChIP-Seq_ESCs_Human1.57440538
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.56129118
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55026789
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51716353
36CBP_20019798_ChIP-Seq_JUKART_Human1.51716353
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47185606
38CRX_20693478_ChIP-Seq_RETINA_Mouse1.45479268
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44640481
40OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43868524
41IRF8_22096565_ChIP-ChIP_GC-B_Human1.43179045
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43146604
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42194636
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41296233
45RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.39642667
46ZNF274_21170338_ChIP-Seq_K562_Hela1.39622117
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.39453874
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33218219
49TP53_16413492_ChIP-PET_HCT116_Human1.31542347
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.29551599
51CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.27904931
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26205448
53CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25673104
54NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25099968
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24158691
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23964074
57TP53_22573176_ChIP-Seq_HFKS_Human1.23290445
58GATA3_26560356_Chip-Seq_TH2_Human1.23228997
59GATA2_21666600_ChIP-Seq_HMVEC_Human1.22420735
60DCP1A_22483619_ChIP-Seq_HELA_Human1.20713813
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20630402
62OCT4_21477851_ChIP-Seq_ESCs_Mouse1.19529278
63GBX2_23144817_ChIP-Seq_PC3_Human1.18243914
64FLI1_21867929_ChIP-Seq_TH2_Mouse1.16870691
65P53_22387025_ChIP-Seq_ESCs_Mouse1.16460458
66KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.14926244
67P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13634276
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12556249
69MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.12153804
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12127149
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.10982339
72CMYC_18555785_Chip-Seq_ESCs_Mouse1.08765181
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08568195
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.07749436
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.07731778
76SCL_19346495_ChIP-Seq_HPC-7_Human1.07214377
77SALL4_22934838_ChIP-ChIP_CD34+_Human1.06505255
78SMAD4_21799915_ChIP-Seq_A2780_Human1.05968800
79SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05828628
80AR_20517297_ChIP-Seq_VCAP_Human1.05617099
81EGR1_19374776_ChIP-ChIP_THP-1_Human1.05605303
82E2F1_18555785_Chip-Seq_ESCs_Mouse1.05384281
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.05210273
84STAT3_23295773_ChIP-Seq_U87_Human1.04732796
85SPI1_23547873_ChIP-Seq_NB4_Human1.04034855
86TP53_18474530_ChIP-ChIP_U2OS_Human1.03802493
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03544643
88FOXP3_21729870_ChIP-Seq_TREG_Human1.03289752
89NANOG_19829295_ChIP-Seq_ESCs_Human1.03252352
90SOX2_19829295_ChIP-Seq_ESCs_Human1.03252352
91FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03019994
92FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01673719
93IRF8_27001747_Chip-Seq_BMDM_Mouse1.01651994
94CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01386737
95CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98204653
96PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97034389
97CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.94509798
98MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93876877
99PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93452481
100Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.93205511

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy4.46303855
2MP0000516_abnormal_urinary_system3.95469148
3MP0005367_renal/urinary_system_phenotyp3.95469148
4MP0002234_abnormal_pharynx_morphology3.67468167
5MP0003880_abnormal_central_pattern3.26042170
6MP0003950_abnormal_plasma_membrane2.68236530
7MP0006054_spinal_hemorrhage2.62056507
8MP0008058_abnormal_DNA_repair2.45539650
9MP0002102_abnormal_ear_morphology2.37194028
10MP0009697_abnormal_copulation2.22676821
11MP0003890_abnormal_embryonic-extraembry2.11530958
12MP0001835_abnormal_antigen_presentation1.95150793
13MP0003656_abnormal_erythrocyte_physiolo1.92317445
14MP0003186_abnormal_redox_activity1.90923818
15MP0001790_abnormal_immune_system1.90179460
16MP0005387_immune_system_phenotype1.90179460
17MP0001727_abnormal_embryo_implantation1.87254163
18MP0001919_abnormal_reproductive_system1.83067955
19MP0003300_gastrointestinal_ulcer1.79600580
20MP0006072_abnormal_retinal_apoptosis1.78195121
21MP0009764_decreased_sensitivity_to1.77864100
22MP0002332_abnormal_exercise_endurance1.75025922
23MP0001501_abnormal_sleep_pattern1.73599933
24MP0000685_abnormal_immune_system1.68418479
25MP0010352_gastrointestinal_tract_polyps1.62163657
26MP0003195_calcinosis1.53669449
27MP0010307_abnormal_tumor_latency1.51258959
28MP0002148_abnormal_hypersensitivity_rea1.50850953
29MP0000371_diluted_coat_color1.48933567
30MP0002751_abnormal_autonomic_nervous1.48759846
31MP0002163_abnormal_gland_morphology1.44054329
32MP0000015_abnormal_ear_pigmentation1.43964684
33MP0002837_dystrophic_cardiac_calcinosis1.40930523
34MP0005310_abnormal_salivary_gland1.37608441
35MP0003221_abnormal_cardiomyocyte_apopto1.36721401
36MP0005410_abnormal_fertilization1.35522384
37MP0009046_muscle_twitch1.34965315
38MP0004142_abnormal_muscle_tone1.34949362
39MP0003121_genomic_imprinting1.32995489
40MP0003172_abnormal_lysosome_physiology1.29665558
41MP0001800_abnormal_humoral_immune1.28125152
42MP0005000_abnormal_immune_tolerance1.27552895
43MP0001986_abnormal_taste_sensitivity1.27318736
44MP0005266_abnormal_metabolism1.20803756
45MP0005253_abnormal_eye_physiology1.18649226
46MP0006276_abnormal_autonomic_nervous1.18624577
47MP0005409_darkened_coat_color1.17955399
48MP0005389_reproductive_system_phenotype1.17733289
49MP0008995_early_reproductive_senescence1.17706590
50MP0001984_abnormal_olfaction1.16803495
51MP0006035_abnormal_mitochondrial_morpho1.16025293
52MP0008789_abnormal_olfactory_epithelium1.15796967
53MP0004947_skin_inflammation1.15234009
54MP0000569_abnormal_digit_pigmentation1.14605216
55MP0003303_peritoneal_inflammation1.14339897
56MP0008057_abnormal_DNA_replication1.13950740
57MP0003866_abnormal_defecation1.13741665
58MP0005386_behavior/neurological_phenoty1.11968100
59MP0004924_abnormal_behavior1.11968100
60MP0000465_gastrointestinal_hemorrhage1.11504506
61MP0002723_abnormal_immune_serum1.05467232
62MP0003566_abnormal_cell_adhesion1.02180459
63MP0002452_abnormal_antigen_presenting1.01957856
64MP0001529_abnormal_vocalization0.98464129
65MP0002095_abnormal_skin_pigmentation0.94547586
66MP0006036_abnormal_mitochondrial_physio0.91700225
67MP0002420_abnormal_adaptive_immunity0.91547482
68MP0004084_abnormal_cardiac_muscle0.91492285
69MP0001819_abnormal_immune_cell0.91444274
70MP0002405_respiratory_system_inflammati0.88123070
71MP0005379_endocrine/exocrine_gland_phen0.87481918
72MP0005384_cellular_phenotype0.86723216
73MP0005423_abnormal_somatic_nervous0.84488832
74MP0002166_altered_tumor_susceptibility0.82679923
75MP0006082_CNS_inflammation0.82418147
76MP0004233_abnormal_muscle_weight0.82122353
77MP0000358_abnormal_cell_content/0.81386615
78MP0003724_increased_susceptibility_to0.80714582
79MP0000427_abnormal_hair_cycle0.80377861
80MP0002398_abnormal_bone_marrow0.79288519
81MP0005025_abnormal_response_to0.78968348
82MP0000716_abnormal_immune_system0.78155471
83MP0005621_abnormal_cell_physiology0.75362875
84MP0003828_pulmonary_edema0.72905232
85MP0009785_altered_susceptibility_to0.71946683
86MP0005075_abnormal_melanosome_morpholog0.71642302
87MP0002419_abnormal_innate_immunity0.71210605
88MP0002075_abnormal_coat/hair_pigmentati0.70780380
89MP0005174_abnormal_tail_pigmentation0.70275394
90MP0004145_abnormal_muscle_electrophysio0.69161355
91MP0002168_other_aberrant_phenotype0.69139971
92MP0003111_abnormal_nucleus_morphology0.68780370
93MP0003787_abnormal_imprinting0.68720744
94MP0002876_abnormal_thyroid_physiology0.66500969
95MP0000604_amyloidosis0.66461225
96MP0000750_abnormal_muscle_regeneration0.66432923
97MP0003045_fibrosis0.64966742
98MP0001845_abnormal_inflammatory_respons0.64109803
99MP0005647_abnormal_sex_gland0.62738772
100MP0001119_abnormal_female_reproductive0.61768092

Predicted human phenotypes

RankGene SetZ-score
13-Methylglutaconic aciduria (HP:0003535)5.43996048
2Medial flaring of the eyebrow (HP:0010747)5.12698427
3Aplasia/Hypoplasia of the uvula (HP:0010293)5.05981234
4Congenital primary aphakia (HP:0007707)4.84351703
5Gait imbalance (HP:0002141)4.75244143
6Nephrogenic diabetes insipidus (HP:0009806)4.40145739
7Abnormality of chromosome stability (HP:0003220)4.33148259
8Meckel diverticulum (HP:0002245)4.29316419
9Abnormality of the ileum (HP:0001549)4.15457161
10Abnormality of the preputium (HP:0100587)3.99981557
11Poor coordination (HP:0002370)3.90639737
12Genital tract atresia (HP:0001827)3.88781680
13Aqueductal stenosis (HP:0002410)3.74488286
14Clubbing of toes (HP:0100760)3.54301659
15Vaginal atresia (HP:0000148)3.46897309
16Astigmatism (HP:0000483)3.30810448
17Aplasia/Hypoplasia of the lens (HP:0008063)3.27193045
18Papillary thyroid carcinoma (HP:0002895)3.25240776
19Neoplasm of the oral cavity (HP:0100649)3.24547717
20Abnormality of the carotid arteries (HP:0005344)3.23916031
21Abnormal umbilical cord blood vessels (HP:0011403)3.08465122
22Single umbilical artery (HP:0001195)3.08465122
23Abnormality of the fetal cardiovascular system (HP:0010948)3.08465122
24Global brain atrophy (HP:0002283)3.04246023
25Type II lissencephaly (HP:0007260)3.02755900
26Retinal dysplasia (HP:0007973)3.00435588
27Amniotic constriction ring (HP:0009775)2.97825520
28Abnormality of placental membranes (HP:0011409)2.97825520
29Abnormality of lateral ventricle (HP:0030047)2.92254838
30Congenital, generalized hypertrichosis (HP:0004540)2.78526603
31Broad alveolar ridges (HP:0000187)2.58332820
32Thyroid carcinoma (HP:0002890)2.54695255
33Medulloblastoma (HP:0002885)2.53138633
34Molar tooth sign on MRI (HP:0002419)2.50003921
35Abnormality of midbrain morphology (HP:0002418)2.50003921
36Decreased testicular size (HP:0008734)2.48618703
37Aplasia/Hypoplasia of the tibia (HP:0005772)2.46073384
38Absent thumb (HP:0009777)2.44779047
39Duodenal stenosis (HP:0100867)2.37842690
40Small intestinal stenosis (HP:0012848)2.37842690
41Thyroiditis (HP:0100646)2.36329877
42Short chin (HP:0000331)2.36066415
43Bifid tongue (HP:0010297)2.30305213
44Broad foot (HP:0001769)2.29581350
45B lymphocytopenia (HP:0010976)2.26667968
46Arteriovenous malformation (HP:0100026)2.25417334
47Myelodysplasia (HP:0002863)2.22496901
48Short tibia (HP:0005736)2.21785645
49Absent speech (HP:0001344)2.20260304
50Testicular atrophy (HP:0000029)2.19244113
51Aplasia/Hypoplasia of the sacrum (HP:0008517)2.12631726
52Severe combined immunodeficiency (HP:0004430)2.12134293
53Left ventricular hypertrophy (HP:0001712)2.11573005
54Neoplasm of the adrenal cortex (HP:0100641)2.10608700
55Abnormality of the vasculature of the conjunctiva (HP:0008054)2.10602342
56Conjunctival telangiectasia (HP:0000524)2.06919353
57Abnormality of B cell number (HP:0010975)2.03819466
58Genetic anticipation (HP:0003743)2.03617943
59Specific learning disability (HP:0001328)2.03422182
60Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.00935244
61Metaphyseal dysplasia (HP:0100255)2.00121979
62Increased IgM level (HP:0003496)1.98976158
63Abolished electroretinogram (ERG) (HP:0000550)1.97708502
64Short foot (HP:0001773)1.97354850
65Postaxial hand polydactyly (HP:0001162)1.95040904
66Bone marrow hypocellularity (HP:0005528)1.93881385
67Amyotrophic lateral sclerosis (HP:0007354)1.93502046
68Widely spaced teeth (HP:0000687)1.91875745
69Parakeratosis (HP:0001036)1.90142967
70Flat occiput (HP:0005469)1.90096464
71Aganglionic megacolon (HP:0002251)1.89743876
72Median cleft lip (HP:0000161)1.89667764
73Increased CSF lactate (HP:0002490)1.88390555
74Asthma (HP:0002099)1.87270435
75Hepatocellular necrosis (HP:0001404)1.85645400
76Gingival bleeding (HP:0000225)1.83874510
77Abnormalities of placenta or umbilical cord (HP:0001194)1.82531046
78Microvesicular hepatic steatosis (HP:0001414)1.81153668
79Capillary hemangiomas (HP:0005306)1.80749506
80Breast carcinoma (HP:0003002)1.80071848
81Stomach cancer (HP:0012126)1.79809786
82Abnormality of the duodenum (HP:0002246)1.78436569
83Pancreatic cysts (HP:0001737)1.76985383
84Autoimmune hemolytic anemia (HP:0001890)1.75686116
85Microcytic anemia (HP:0001935)1.75155247
86Acute hepatic failure (HP:0006554)1.73777218
87Abnormality of binocular vision (HP:0011514)1.70795302
88Diplopia (HP:0000651)1.70795302
89Type I transferrin isoform profile (HP:0003642)1.69139074
90Nephrotic syndrome (HP:0000100)1.65795877
91Acute necrotizing encephalopathy (HP:0006965)1.64518739
92Childhood onset (HP:0011463)1.64513160
93Lip pit (HP:0100267)1.60199840
94Eosinophilia (HP:0001880)1.59932569
95Retinitis pigmentosa (HP:0000510)1.59580704
96Cutaneous melanoma (HP:0012056)1.59075563
97Stenosis of the external auditory canal (HP:0000402)1.58616879
98Cerebellar dysplasia (HP:0007033)1.57589028
99Facial hemangioma (HP:0000329)1.56943073
100Microglossia (HP:0000171)1.55689874

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.79006846
2ERBB33.78090935
3BMPR1B3.65733607
4BCR3.53112431
5FRK3.52502692
6EIF2AK12.84492491
7TRIM282.62464446
8OXSR12.55402010
9ACVR1B2.55096322
10STK392.47053031
11MKNK22.33182050
12MAP4K22.30958884
13NUAK12.08235571
14BRD42.02901558
15EIF2AK32.01981086
16PIK3CG1.97811787
17SIK31.82602652
18DAPK21.79097767
19ZAK1.74512438
20ILK1.61181799
21MYLK1.58078447
22EPHA31.57846456
23PKN11.49269878
24DYRK31.48484147
25CDK191.32229144
26PIK3CA1.25826843
27MAP3K131.23347041
28RAF11.14949701
29MAPK131.09146716
30CLK11.08568125
31MAP3K41.07268163
32DAPK31.06184745
33DAPK11.04666009
34CAMKK21.04323818
35WNK31.03693027
36PRKCE0.99412108
37KSR10.97639648
38ROCK20.95245979
39NEK60.92451978
40BMPR20.92450192
41CAMK40.92085122
42TNIK0.90831710
43YES10.90285182
44PTK2B0.83216200
45MKNK10.82147727
46PBK0.80877699
47BLK0.77091025
48CDK80.76361299
49UHMK10.75911930
50RPS6KA40.75543933
51PAK30.71961824
52PAK40.67235469
53CAMK10.65247132
54TNK20.65199742
55MST40.63818840
56CHUK0.62428062
57CAMK1D0.61556978
58TGFBR10.59787431
59ROCK10.58222882
60CCNB10.57836963
61EPHA40.57196987
62CDK40.56990657
63LATS10.56299921
64EGFR0.55512126
65CHEK20.53068601
66MELK0.48009600
67GRK10.47260138
68ATR0.44209355
69PIM20.43009086
70HCK0.41446574
71IRAK10.40848015
72FLT30.40835452
73MAP3K50.39980014
74KIT0.39819772
75TAOK20.35468785
76DYRK1A0.35301915
77CAMK1G0.34876412
78CSNK1A1L0.32857923
79STK160.32575327
80CSNK1G30.31680455
81FGFR20.31584496
82STK110.30172327
83FGR0.29903123
84MARK30.29109565
85CDK30.28931581
86CDK180.28269691
87RPS6KA50.27223840
88MARK10.26578665
89LYN0.25274687
90PINK10.24746439
91ATM0.23341126
92MARK20.23019245
93CAMK2A0.22399979
94PRKAA20.22356880
95ADRBK10.21651830
96PLK40.21589414
97CSNK1D0.20505203
98MAP3K90.20458383
99CDK50.20282632
100FGFR10.19130412

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.45343401
2Fanconi anemia pathway_Homo sapiens_hsa034603.91563969
3Pantothenate and CoA biosynthesis_Homo sapiens_hsa007703.08994109
4Non-homologous end-joining_Homo sapiens_hsa034502.76460910
5Oxidative phosphorylation_Homo sapiens_hsa001902.68466061
6Type I diabetes mellitus_Homo sapiens_hsa049402.56623648
7Homologous recombination_Homo sapiens_hsa034402.18127230
8Allograft rejection_Homo sapiens_hsa053302.17753373
9Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.94071804
10Olfactory transduction_Homo sapiens_hsa047401.86360746
11Asthma_Homo sapiens_hsa053101.82722638
12Parkinsons disease_Homo sapiens_hsa050121.81668014
13Graft-versus-host disease_Homo sapiens_hsa053321.73613012
14Circadian rhythm_Homo sapiens_hsa047101.68274230
15Folate biosynthesis_Homo sapiens_hsa007901.64980278
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.64881632
17Autoimmune thyroid disease_Homo sapiens_hsa053201.62182713
18GABAergic synapse_Homo sapiens_hsa047271.61473510
19RNA degradation_Homo sapiens_hsa030181.60813501
20Pertussis_Homo sapiens_hsa051331.57959461
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.52172014
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.50778571
23Cardiac muscle contraction_Homo sapiens_hsa042601.49057796
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48943665
25Mismatch repair_Homo sapiens_hsa034301.48774853
26Steroid biosynthesis_Homo sapiens_hsa001001.46615422
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.45040484
28Huntingtons disease_Homo sapiens_hsa050161.40876634
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40139126
30Proteasome_Homo sapiens_hsa030501.37660692
31Butanoate metabolism_Homo sapiens_hsa006501.36873590
32Alzheimers disease_Homo sapiens_hsa050101.35411027
33African trypanosomiasis_Homo sapiens_hsa051431.33870754
34p53 signaling pathway_Homo sapiens_hsa041151.28371245
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.28005218
36Leishmaniasis_Homo sapiens_hsa051401.26367116
37Legionellosis_Homo sapiens_hsa051341.24625528
38Hematopoietic cell lineage_Homo sapiens_hsa046401.16871935
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13668576
40Sphingolipid metabolism_Homo sapiens_hsa006001.12768514
41Rheumatoid arthritis_Homo sapiens_hsa053231.07222070
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.05394940
43Nucleotide excision repair_Homo sapiens_hsa034201.04968964
44Collecting duct acid secretion_Homo sapiens_hsa049661.03952965
45Tuberculosis_Homo sapiens_hsa051521.02461631
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99040289
47Spliceosome_Homo sapiens_hsa030400.98259790
48RNA polymerase_Homo sapiens_hsa030200.98223497
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97807290
50Regulation of autophagy_Homo sapiens_hsa041400.96119208
51Basal transcription factors_Homo sapiens_hsa030220.95210244
52Viral myocarditis_Homo sapiens_hsa054160.92827337
53Phototransduction_Homo sapiens_hsa047440.91077818
54mRNA surveillance pathway_Homo sapiens_hsa030150.90137807
55Malaria_Homo sapiens_hsa051440.82554921
56RNA transport_Homo sapiens_hsa030130.82377947
57Toxoplasmosis_Homo sapiens_hsa051450.82222861
58Jak-STAT signaling pathway_Homo sapiens_hsa046300.77182822
59Influenza A_Homo sapiens_hsa051640.75377174
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73970675
61Morphine addiction_Homo sapiens_hsa050320.73525807
62Measles_Homo sapiens_hsa051620.73051241
63Chemokine signaling pathway_Homo sapiens_hsa040620.72100090
64Nicotine addiction_Homo sapiens_hsa050330.71468549
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69975684
66mTOR signaling pathway_Homo sapiens_hsa041500.65107570
67Hepatitis B_Homo sapiens_hsa051610.64782827
68Vibrio cholerae infection_Homo sapiens_hsa051100.62483272
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59738554
70Phagosome_Homo sapiens_hsa041450.56660856
71Herpes simplex infection_Homo sapiens_hsa051680.55497667
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53842355
73Bladder cancer_Homo sapiens_hsa052190.53396645
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53129185
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49363428
76Oocyte meiosis_Homo sapiens_hsa041140.48504065
77Cholinergic synapse_Homo sapiens_hsa047250.47226136
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46988786
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45971982
80One carbon pool by folate_Homo sapiens_hsa006700.36982626
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.35097178
82Glutamatergic synapse_Homo sapiens_hsa047240.34627469
83FoxO signaling pathway_Homo sapiens_hsa040680.33163000
84Taste transduction_Homo sapiens_hsa047420.33079241
85Colorectal cancer_Homo sapiens_hsa052100.32724766
86Pyrimidine metabolism_Homo sapiens_hsa002400.32629283
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.32222355
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31968242
89Axon guidance_Homo sapiens_hsa043600.30176049
90Alcoholism_Homo sapiens_hsa050340.29310138
91Endocytosis_Homo sapiens_hsa041440.28653535
92Dopaminergic synapse_Homo sapiens_hsa047280.28324217
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.28227839
94Staphylococcus aureus infection_Homo sapiens_hsa051500.25878411
95Circadian entrainment_Homo sapiens_hsa047130.25155479
96Ras signaling pathway_Homo sapiens_hsa040140.24475986
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.23236860
98Gastric acid secretion_Homo sapiens_hsa049710.22741561
99ABC transporters_Homo sapiens_hsa020100.21183745
100Cell cycle_Homo sapiens_hsa041100.19870995

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