XCL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)9.91604060
2regulation of isotype switching to IgG isotypes (GO:0048302)9.41480218
3regulation of podosome assembly (GO:0071801)9.40003273
4regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)8.67402926
5positive regulation of humoral immune response (GO:0002922)8.44184784
6positive regulation of immune response to tumor cell (GO:0002839)7.89112096
7regulation of immune response to tumor cell (GO:0002837)7.89112096
8regulation of response to tumor cell (GO:0002834)7.89112096
9positive regulation of response to tumor cell (GO:0002836)7.89112096
10activated T cell proliferation (GO:0050798)7.83585220
11* positive regulation of B cell mediated immunity (GO:0002714)7.76939472
12* positive regulation of immunoglobulin mediated immune response (GO:0002891)7.76939472
13positive regulation of isotype switching (GO:0045830)7.28679982
14regulation of interleukin-12 biosynthetic process (GO:0045075)7.21516197
15positive regulation of inflammatory response to antigenic stimulus (GO:0002863)7.18814697
16regulation of chronic inflammatory response (GO:0002676)6.93005068
17interferon-gamma production (GO:0032609)6.84584183
18positive regulation of macrophage derived foam cell differentiation (GO:0010744)6.79532760
19positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)6.30198457
20regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)6.30198457
21positive regulation of DNA recombination (GO:0045911)6.17730619
22regulation of regulatory T cell differentiation (GO:0045589)6.09391845
23myeloid dendritic cell differentiation (GO:0043011)6.04169264
24regulation of RIG-I signaling pathway (GO:0039535)6.00093063
25* regulation of immunoglobulin mediated immune response (GO:0002889)5.93748897
26positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.84790645
27positive regulation of natural killer cell mediated immunity (GO:0002717)5.84790645
28DNA deamination (GO:0045006)5.83040116
29* regulation of B cell mediated immunity (GO:0002712)5.72757065
30regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.44475297
31regulation of natural killer cell mediated immunity (GO:0002715)5.41581980
32regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.41581980
33cytidine metabolic process (GO:0046087)5.34456501
34cytidine catabolic process (GO:0006216)5.34456501
35cytidine deamination (GO:0009972)5.34456501
36regulation of vitamin D biosynthetic process (GO:0060556)5.33770388
37modulation of growth of symbiont involved in interaction with host (GO:0044144)5.29937311
38regulation of growth of symbiont in host (GO:0044126)5.29937311
39negative regulation of growth of symbiont in host (GO:0044130)5.29937311
40negative regulation of growth of symbiont involved in interaction with host (GO:0044146)5.29937311
41myeloid dendritic cell activation (GO:0001773)5.26705275
42regulation of isotype switching (GO:0045191)5.24515191
43regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033395.21254578
44regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)5.17074728
45regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)5.01709461
46phosphorelay signal transduction system (GO:0000160)5.00853768
47pyrimidine ribonucleoside catabolic process (GO:0046133)4.98518477
48* positive regulation of lymphocyte mediated immunity (GO:0002708)4.94346228
49positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)4.93787115
50positive regulation of gamma-delta T cell activation (GO:0046645)4.92276218
51regulation of immunoglobulin secretion (GO:0051023)4.89766213
52metallo-sulfur cluster assembly (GO:0031163)4.79747225
53iron-sulfur cluster assembly (GO:0016226)4.79747225
54regulation of vitamin metabolic process (GO:0030656)4.73345351
55positive thymic T cell selection (GO:0045059)4.71800670
56oxygen transport (GO:0015671)4.57828816
57positive regulation of defense response to virus by host (GO:0002230)4.56526994
58negative regulation of execution phase of apoptosis (GO:1900118)4.43963228
59positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.42745104
60regulation of gamma-delta T cell differentiation (GO:0045586)4.41964017
61positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)4.40771073
62mast cell activation involved in immune response (GO:0002279)4.32316680
63mast cell degranulation (GO:0043303)4.32316680
64regulation of tyrosine phosphorylation of STAT protein (GO:0042509)4.27836428
65* positive regulation of leukocyte mediated immunity (GO:0002705)4.23609043
66* positive regulation of cell killing (GO:0031343)4.21425951
67* positive regulation of immunoglobulin production (GO:0002639)4.20935975
68positive T cell selection (GO:0043368)4.19708801
69tyrosine phosphorylation of STAT protein (GO:0007260)4.16182900
70cellular response to interleukin-15 (GO:0071350)4.13097359
71regulation of memory T cell differentiation (GO:0043380)4.12539302
72positive regulation of JAK-STAT cascade (GO:0046427)4.07439843
73NIK/NF-kappaB signaling (GO:0038061)4.07034518
74cellular defense response (GO:0006968)4.06173239
75* positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.05928316
76activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO4.03195145
77* regulation of lymphocyte mediated immunity (GO:0002706)4.02706555
78response to interleukin-15 (GO:0070672)4.00090832
79positive regulation of activated T cell proliferation (GO:0042104)3.96708101
80L-fucose catabolic process (GO:0042355)3.93644701
81fucose catabolic process (GO:0019317)3.93644701
82L-fucose metabolic process (GO:0042354)3.93644701
83T cell proliferation (GO:0042098)3.87111553
84regulation of gamma-delta T cell activation (GO:0046643)3.85598109
85* positive regulation of T cell mediated cytotoxicity (GO:0001916)3.84771353
86* regulation of lymphocyte chemotaxis (GO:1901623)3.81581896
87mast cell activation (GO:0045576)3.78870803
88regulation of inflammatory response to antigenic stimulus (GO:0002861)3.75118760
89* regulation of T cell mediated cytotoxicity (GO:0001914)3.72986912
90negative regulation of viral transcription (GO:0032897)3.72897311
91* regulation of immunoglobulin production (GO:0002637)3.72264625
92positive regulation of astrocyte differentiation (GO:0048711)3.66220582
93negative T cell selection (GO:0043383)3.66173903
94negative regulation of heart rate (GO:0010459)3.65366783
95lymph node development (GO:0048535)3.64358751
96regulation of interleukin-2 biosynthetic process (GO:0045076)3.63615824
97regulation of macrophage derived foam cell differentiation (GO:0010743)3.63326428
98positive regulation of interleukin-17 production (GO:0032740)3.63301987
99positive regulation of organelle assembly (GO:1902117)3.62549512
100* regulation of cell killing (GO:0031341)3.62503253
101rRNA methylation (GO:0031167)3.60372119
102GDP-mannose metabolic process (GO:0019673)3.57713433
103* regulation of leukocyte mediated cytotoxicity (GO:0001910)3.57444361
104cytokine production (GO:0001816)3.55535703
105transcription elongation from RNA polymerase III promoter (GO:0006385)3.54281551
106termination of RNA polymerase III transcription (GO:0006386)3.54281551
107* positive regulation of adaptive immune response based on somatic recombination of immune receptors b3.50560643
108folic acid-containing compound biosynthetic process (GO:0009396)3.48727020
109regulation of defense response to virus by host (GO:0050691)3.47259587
110T cell receptor signaling pathway (GO:0050852)3.46964420
111* positive regulation of T cell chemotaxis (GO:0010820)3.44171917
112* regulation of T cell chemotaxis (GO:0010819)3.44171917
113JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.44115026
114dendritic cell differentiation (GO:0097028)3.42941980
115positive regulation of natural killer cell differentiation (GO:0032825)3.38229809
116thymic T cell selection (GO:0045061)3.37221207
117regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.36774310
118positive regulation of hormone biosynthetic process (GO:0046886)3.36722196
119negative thymic T cell selection (GO:0045060)3.36087272
120negative regulation of B cell apoptotic process (GO:0002903)3.31954352
121* positive regulation of adaptive immune response (GO:0002821)3.31539463
122Peyers patch development (GO:0048541)3.31509911
123mucosal-associated lymphoid tissue development (GO:0048537)3.31509911
124inflammatory response to antigenic stimulus (GO:0002437)3.29283433
125negative regulation of cell killing (GO:0031342)3.29018354
126negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.29018354
127positive regulation of chemokine biosynthetic process (GO:0045080)3.26793632
128antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.25918095
129antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.25918095
130poly(A)+ mRNA export from nucleus (GO:0016973)3.25679825
131rRNA modification (GO:0000154)3.25252257
132cellular response to nicotine (GO:0071316)3.24752259
133positive regulation of interferon-gamma production (GO:0032729)3.20390118
134natural killer cell differentiation (GO:0001779)3.16728281
135T cell costimulation (GO:0031295)3.15415810
136T cell mediated immunity (GO:0002456)3.13408643
137antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.12005401
138defense response to protozoan (GO:0042832)3.10952315
139mRNA cleavage (GO:0006379)3.09902534
140regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.09312231
141positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.08728120
142regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.08585987
143lymphocyte costimulation (GO:0031294)3.08254026
144regulation of B cell receptor signaling pathway (GO:0050855)3.07962555
145regulation of interleukin-17 production (GO:0032660)3.07739418
146negative regulation of interleukin-12 production (GO:0032695)3.05656860
147natural killer cell activation (GO:0030101)3.04841649
148leukocyte aggregation (GO:0070486)3.02999365
149* positive regulation of T-helper 1 type immune response (GO:0002827)2.98705644
150* regulation of T-helper 1 type immune response (GO:0002825)2.95716192
151piRNA metabolic process (GO:0034587)2.94633953
152positive regulation of protein homodimerization activity (GO:0090073)2.93508919
153protein polyglutamylation (GO:0018095)2.87339177
154alpha-beta T cell differentiation involved in immune response (GO:0002293)2.86856925
155alpha-beta T cell activation involved in immune response (GO:0002287)2.86856925
156T cell differentiation involved in immune response (GO:0002292)2.86856925
157CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.84486570
158T-helper cell differentiation (GO:0042093)2.84486570
159positive regulation of granulocyte differentiation (GO:0030854)2.84045056
160negative regulation of T-helper cell differentiation (GO:0045623)2.77327496
161negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.77327496
162T cell migration (GO:0072678)2.76682529
163leukocyte degranulation (GO:0043299)2.72406084
164positive regulation of hormone metabolic process (GO:0032352)2.70637547
165positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)10.5414560

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.88372283
2* FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.16804922
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human7.04552973
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human5.85148931
5* STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.60931629
6STAT4_19710469_ChIP-ChIP_TH1__Mouse4.24045657
7NOTCH1_21737748_ChIP-Seq_TLL_Human3.73407311
8RUNX_20019798_ChIP-Seq_JUKART_Human3.43132229
9FLI1_27457419_Chip-Seq_LIVER_Mouse3.42702626
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.32363572
11PCGF2_27294783_Chip-Seq_ESCs_Mouse3.19856989
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.13199389
13VDR_22108803_ChIP-Seq_LS180_Human3.08910511
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.08090888
15MYC_22102868_ChIP-Seq_BL_Human3.07489335
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.04199189
17PCGF2_27294783_Chip-Seq_NPCs_Mouse2.95136377
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.82784587
19MYB_26560356_Chip-Seq_TH2_Human2.81923044
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.70671625
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.69677330
22* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.64819278
23TP63_17297297_ChIP-ChIP_HaCaT_Human2.56906688
24ZNF274_21170338_ChIP-Seq_K562_Hela2.37450413
25* MYB_26560356_Chip-Seq_TH1_Human2.35828923
26MAF_26560356_Chip-Seq_TH1_Human2.34377946
27GATA3_27048872_Chip-Seq_THYMUS_Human2.25575936
28GABP_17652178_ChIP-ChIP_JURKAT_Human2.23225664
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.07340911
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.96744529
31UTX_26944678_Chip-Seq_JUKART_Human1.96574419
32MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.88793759
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.88254834
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.83618902
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.83294143
36KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.80054655
37VDR_23849224_ChIP-Seq_CD4+_Human1.79602550
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.68859545
39TCF7_22412390_ChIP-Seq_EML_Mouse1.68704859
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66569425
41EST1_17652178_ChIP-ChIP_JURKAT_Human1.66536044
42KDM2B_26808549_Chip-Seq_DND41_Human1.61428828
43* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59989220
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.57433583
45NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.57166250
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.56037927
47EGR1_19032775_ChIP-ChIP_M12_Human1.54230974
48FOXP3_21729870_ChIP-Seq_TREG_Human1.52579709
49MAF_26560356_Chip-Seq_TH2_Human1.52434147
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.52426532
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51413798
52* NFE2_27457419_Chip-Seq_LIVER_Mouse1.49727492
53E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.48884814
54E2F7_22180533_ChIP-Seq_HELA_Human1.48014444
55SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45154461
56IRF8_22096565_ChIP-ChIP_GC-B_Human1.44742271
57NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44556030
58RUNX1_22412390_ChIP-Seq_EML_Mouse1.42486473
59* BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.41421589
60VDR_24763502_ChIP-Seq_THP-1_Human1.40762815
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36826434
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36648097
63IRF8_27001747_Chip-Seq_BMDM_Mouse1.35052682
64VDR_21846776_ChIP-Seq_THP-1_Human1.33340139
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32604465
66E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32286026
67* EZH2_27294783_Chip-Seq_NPCs_Mouse1.30356073
68ETS1_20019798_ChIP-Seq_JURKAT_Human1.29648970
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.28645899
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.26542235
71RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.26062403
72IRF8_21731497_ChIP-ChIP_J774_Mouse1.25385368
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24061411
74EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23983813
75MYC_18555785_ChIP-Seq_MESCs_Mouse1.23015899
76ZNF263_19887448_ChIP-Seq_K562_Human1.21326944
77VDR_24787735_ChIP-Seq_THP-1_Human1.20497814
78PU_27001747_Chip-Seq_BMDM_Mouse1.20013357
79* GATA3_26560356_Chip-Seq_TH2_Human1.18882699
80CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17386449
81SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16756512
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14807430
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13964911
84RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13791299
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.13475885
86NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11905980
87SRF_21415370_ChIP-Seq_HL-1_Mouse1.11357931
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09247517
89TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07418932
90MYC_19079543_ChIP-ChIP_MESCs_Mouse1.06666008
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04219376
92SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04039576
93SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04039576
94IRF1_19129219_ChIP-ChIP_H3396_Human1.02539940
95EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.01184273
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00806456
97MYC_18940864_ChIP-ChIP_HL60_Human0.99729031
98* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98342343
99FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97501614
100BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96829641
101MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96751824
102FOXH1_21741376_ChIP-Seq_EPCs_Human0.96558965
103TAF15_26573619_Chip-Seq_HEK293_Human0.96250805
104SPI1_23547873_ChIP-Seq_NB4_Human0.96215061
105SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.95400659
106GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94218651
107FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93605277
108CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93456282
109SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92667464
110PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92534070
111* HOXB7_26014856_ChIP-Seq_BT474_Human0.91949885
112YY1_21170310_ChIP-Seq_MESCs_Mouse0.91045561
113VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90820802
114PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.90182980
115MYC_19829295_ChIP-Seq_ESCs_Human0.90015384
116ELK3_25401928_ChIP-Seq_HUVEC_Human0.89313697
117STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88768818
118GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87834250
119* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87400603
120SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.87371416
121HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87314279
122SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.87211754
123FOXH1_21741376_ChIP-Seq_ESCs_Human0.86827389
124NANOG_20526341_ChIP-Seq_ESCs_Human0.86370732
125* CRX_20693478_ChIP-Seq_RETINA_Mouse0.85268535
126* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.84335444
127ER_23166858_ChIP-Seq_MCF-7_Human0.83922549
128HIF1A_21447827_ChIP-Seq_MCF-7_Human0.83307920
129* OCT4_18555785_Chip-Seq_ESCs_Mouse0.82379818
130KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.81970120
131OCT4_20526341_ChIP-Seq_ESCs_Human0.81096722
132CLOCK_20551151_ChIP-Seq_293T_Human0.80803925
133* GATA6_21074721_ChIP-Seq_CACO-2_Human0.79400247
134* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.79109001
135GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78715543
136AR_21572438_ChIP-Seq_LNCaP_Human0.78661856
137* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.77503936
138CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75927563
139GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.75546621
140TP53_22573176_ChIP-Seq_HFKS_Human0.75386267
141CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75370789
142* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.75197716
143TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.74567960
144VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.74195306
145GATA3_21878914_ChIP-Seq_MCF-7_Human0.73597082
146SMRT_27268052_Chip-Seq_Bcells_Human0.73573547
147ERG_20887958_ChIP-Seq_HPC-7_Mouse0.73547417
148SCL_19346495_ChIP-Seq_HPC-7_Human0.73426569
149PPAR_26484153_Chip-Seq_NCI-H1993_Human0.73311211
150PRDM14_20953172_ChIP-Seq_ESCs_Human0.73229357
151* RBPJ_21746931_ChIP-Seq_IB4_Human0.73091951
152ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.72605508
153GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.72477588
154TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.72192837
155PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69645382
156PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.68850816
157SALL4_22934838_ChIP-ChIP_CD34+_Human0.68576556
158DNAJC2_21179169_ChIP-ChIP_NT2_Human0.67773050
159KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.67257974
160CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.65056471
161GATA3_26560356_Chip-Seq_TH1_Human0.64641521
162GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64160046
163LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.62999524
164CTCF_21964334_ChIP-Seq_BJAB-B_Human0.60396650
165RACK7_27058665_Chip-Seq_MCF-7_Human0.59387063
166ATF3_27146783_Chip-Seq_COLON_Human0.58416487
167KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.58254602
168ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.57978898

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer5.26954359
2MP0005671_abnormal_response_to4.73859327
3MP0001835_abnormal_antigen_presentation4.43102686
4MP0003436_decreased_susceptibility_to4.41893863
5MP0004782_abnormal_surfactant_physiolog4.28313635
6MP0003763_abnormal_thymus_physiology3.61501607
7MP0001958_emphysema3.51322541
8MP0009785_altered_susceptibility_to3.44951433
9MP0002405_respiratory_system_inflammati3.30367689
10MP0000685_abnormal_immune_system3.20937065
11MP0006082_CNS_inflammation3.08343649
12MP0009333_abnormal_splenocyte_physiolog2.83856509
13MP0003646_muscle_fatigue2.83844209
14MP0001853_heart_inflammation2.81718626
15MP0001800_abnormal_humoral_immune2.76227912
16MP0005000_abnormal_immune_tolerance2.65586802
17MP0000465_gastrointestinal_hemorrhage2.56659104
18MP0001501_abnormal_sleep_pattern2.52209697
19MP0003866_abnormal_defecation2.51497572
20MP0005025_abnormal_response_to2.24284655
21MP0002723_abnormal_immune_serum2.23897082
22MP0001873_stomach_inflammation2.19440870
23MP0001819_abnormal_immune_cell2.10703898
24MP0002420_abnormal_adaptive_immunity2.09495695
25MP0000604_amyloidosis2.07868489
26MP0002148_abnormal_hypersensitivity_rea2.05320909
27MP0002398_abnormal_bone_marrow2.04873281
28MP0003303_peritoneal_inflammation2.03766871
29MP0000613_abnormal_salivary_gland2.03082167
30MP0002132_abnormal_respiratory_system2.00836940
31MP0010155_abnormal_intestine_physiology1.89016500
32MP0002396_abnormal_hematopoietic_system1.81667549
33MP0000703_abnormal_thymus_morphology1.81297165
34MP0002452_abnormal_antigen_presenting1.80426213
35MP0004510_myositis1.78923131
36MP0001790_abnormal_immune_system1.77122401
37MP0005387_immune_system_phenotype1.77122401
38MP0002166_altered_tumor_susceptibility1.73408765
39MP0001881_abnormal_mammary_gland1.68991322
40MP0002722_abnormal_immune_system1.68492052
41MP0000689_abnormal_spleen_morphology1.67078970
42MP0000716_abnormal_immune_system1.66689352
43MP0003045_fibrosis1.65712685
44MP0002006_tumorigenesis1.64975786
45MP0005085_abnormal_gallbladder_physiolo1.63784607
46MP0004947_skin_inflammation1.62564839
47MP0000569_abnormal_digit_pigmentation1.59524245
48MP0001533_abnormal_skeleton_physiology1.48190040
49MP0001845_abnormal_inflammatory_respons1.47864785
50MP0005075_abnormal_melanosome_morpholog1.44436383
51MP0002419_abnormal_innate_immunity1.43776699
52MP0001661_extended_life_span1.42838021
53MP0009764_decreased_sensitivity_to1.40175847
54MP0005165_increased_susceptibility_to1.39729710
55MP0008057_abnormal_DNA_replication1.35107202
56MP0005451_abnormal_body_composition1.34309765
57MP0002429_abnormal_blood_cell1.33330068
58MP0010234_abnormal_vibrissa_follicle1.32166091
59MP0003448_altered_tumor_morphology1.31267262
60MP0008961_abnormal_basal_metabolism1.29993473
61MP0001502_abnormal_circadian_rhythm1.28893014
62MP0000013_abnormal_adipose_tissue1.28771832
63MP0000372_irregular_coat_pigmentation1.26342007
64MP0008872_abnormal_physiological_respon1.24659986
65MP0003786_premature_aging1.22902968
66MP0004142_abnormal_muscle_tone1.20013142
67MP0002653_abnormal_ependyma_morphology1.18341935
68MP0010307_abnormal_tumor_latency1.16254445
69MP0000627_abnormal_mammary_gland1.13141043
70MP0001986_abnormal_taste_sensitivity1.07724099
71MP0002089_abnormal_postnatal_growth/wei0.94712578
72MP0000609_abnormal_liver_physiology0.92371298
73MP0004808_abnormal_hematopoietic_stem0.88534885
74MP0004381_abnormal_hair_follicle0.88527224
75MP0002009_preneoplasia0.86568354
76MP0006035_abnormal_mitochondrial_morpho0.86508576
77MP0003453_abnormal_keratinocyte_physiol0.85639579
78MP0000490_abnormal_crypts_of0.84779917
79MP0001851_eye_inflammation0.84287890
80MP0000858_altered_metastatic_potential0.84226861
81MP0004742_abnormal_vestibular_system0.83888977
82MP0005464_abnormal_platelet_physiology0.83381964
83MP0008877_abnormal_DNA_methylation0.83129966
84MP0003705_abnormal_hypodermis_morpholog0.81115636
85MP0005166_decreased_susceptibility_to0.81073818
86MP0003724_increased_susceptibility_to0.79865846
87MP0002019_abnormal_tumor_incidence0.79615833
88MP0000015_abnormal_ear_pigmentation0.78813984
89MP0002933_joint_inflammation0.78469542
90MP0008469_abnormal_protein_level0.77721066
91MP0002138_abnormal_hepatobiliary_system0.77086185
92MP0000358_abnormal_cell_content/0.73813769
93MP0005551_abnormal_eye_electrophysiolog0.72904190
94MP0003878_abnormal_ear_physiology0.72077903
95MP0005377_hearing/vestibular/ear_phenot0.72077903
96MP0003195_calcinosis0.71312277
97MP0009763_increased_sensitivity_to0.70715810
98MP0002876_abnormal_thyroid_physiology0.70609965
99MP0001485_abnormal_pinna_reflex0.70607926
100MP0002254_reproductive_system_inflammat0.70231626
101MP0001727_abnormal_embryo_implantation0.69480461
102MP0005390_skeleton_phenotype0.69345884
103MP0005076_abnormal_cell_differentiation0.68157215
104MP0009765_abnormal_xenobiotic_induced0.66825298
105MP0002909_abnormal_adrenal_gland0.64821767
106MP0005174_abnormal_tail_pigmentation0.62171164
107MP0002998_abnormal_bone_remodeling0.58579560
108MP0001216_abnormal_epidermal_layer0.57348416
109MP0002136_abnormal_kidney_physiology0.56893066
110MP0004185_abnormal_adipocyte_glucose0.55730559
111MP0006036_abnormal_mitochondrial_physio0.53339756
112MP0003959_abnormal_lean_body0.53129402
113MP0004130_abnormal_muscle_cell0.53033619
114MP0005647_abnormal_sex_gland0.51362698
115MP0005410_abnormal_fertilization0.49469875
116MP0006276_abnormal_autonomic_nervous0.48568200
117MP0002693_abnormal_pancreas_physiology0.48391131
118MP0000249_abnormal_blood_vessel0.47227040
119MP0001663_abnormal_digestive_system0.47190503
120MP0009745_abnormal_behavioral_response0.46160206
121MP0009643_abnormal_urine_homeostasis0.45964681
122MP0004885_abnormal_endolymph0.45528384
123MP0001919_abnormal_reproductive_system0.45372198
124MP0005448_abnormal_energy_balance0.45329457
125MP0003252_abnormal_bile_duct0.45195199
126MP0003936_abnormal_reproductive_system0.45001616
127MP0005253_abnormal_eye_physiology0.44512911
128MP0009046_muscle_twitch0.43986267
129MP0000003_abnormal_adipose_tissue0.43683736
130MP0001765_abnormal_ion_homeostasis0.43228322
131MP0005257_abnormal_intraocular_pressure0.42932508
132MP0004484_altered_response_of0.42654084
133MP0000598_abnormal_liver_morphology0.42585686
134MP0002877_abnormal_melanocyte_morpholog0.42102470
135MP0005388_respiratory_system_phenotype0.41489670
136MP0002133_abnormal_respiratory_system0.41489670
137MP0002796_impaired_skin_barrier0.39752940
138MP0005501_abnormal_skin_physiology0.38137459
139MP0003943_abnormal_hepatobiliary_system0.37915614
140MP0000367_abnormal_coat/_hair0.35940081
141MP0005310_abnormal_salivary_gland0.34772850
142MP0008569_lethality_at_weaning0.33266294
143MP0002098_abnormal_vibrissa_morphology0.33260310
144MP0010352_gastrointestinal_tract_polyps0.32754354

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)9.88299568
2Elevated erythrocyte sedimentation rate (HP:0003565)8.86107295
3T lymphocytopenia (HP:0005403)7.27730477
4Abnormality of T cell number (HP:0011839)7.10977790
5Nasal polyposis (HP:0100582)6.12679912
6Autoimmune hemolytic anemia (HP:0001890)5.36695971
7Abnormality of the nasal mucosa (HP:0000433)5.05751045
8Abnormality of the labia minora (HP:0012880)4.43730850
9Abnormality of T cells (HP:0002843)4.36316508
10Gastrointestinal infarctions (HP:0005244)4.34757325
11Joint swelling (HP:0001386)4.01477931
12Keratitis (HP:0000491)3.97032824
13Chronic diarrhea (HP:0002028)3.85957556
14Recurrent viral infections (HP:0004429)3.83968938
15Severe combined immunodeficiency (HP:0004430)3.81264171
16Thrombocytosis (HP:0001894)3.77717379
17IgG deficiency (HP:0004315)3.75884013
18Increased density of long bones (HP:0006392)3.75413437
19Hypoplastic ischia (HP:0003175)3.66815116
20Arterial thrombosis (HP:0004420)3.63562235
213-Methylglutaconic aciduria (HP:0003535)3.63517741
22Anorexia (HP:0002039)3.59192028
23Mediastinal lymphadenopathy (HP:0100721)3.41113833
24Recurrent fungal infections (HP:0002841)3.39495402
25Eczematoid dermatitis (HP:0000976)3.37527487
26Recurrent cutaneous fungal infections (HP:0011370)3.33937119
27Chronic mucocutaneous candidiasis (HP:0002728)3.33937119
28Combined immunodeficiency (HP:0005387)3.25145419
29Slow saccadic eye movements (HP:0000514)3.24026225
30Submucous cleft hard palate (HP:0000176)3.15626005
31Persistence of primary teeth (HP:0006335)3.10939050
32Abnormality of the ischium (HP:0003174)3.03616595
33Myositis (HP:0100614)3.00482463
34Retrobulbar optic neuritis (HP:0100654)2.96929668
35Optic neuritis (HP:0100653)2.96929668
36IgA deficiency (HP:0002720)2.94167046
37Cerebral hypomyelination (HP:0006808)2.91334903
38Septate vagina (HP:0001153)2.89992944
39Congenital stationary night blindness (HP:0007642)2.85278717
40Orchitis (HP:0100796)2.81024156
41Pulmonary infiltrates (HP:0002113)2.78019124
42Abnormality of the endocardium (HP:0004306)2.76625156
43Chest pain (HP:0100749)2.76265991
44Panhypogammaglobulinemia (HP:0003139)2.75950927
45Amaurosis fugax (HP:0100576)2.75073246
46Abnormal delayed hypersensitivity skin test (HP:0002963)2.72975150
47Lymphoma (HP:0002665)2.71837735
48Recurrent bronchitis (HP:0002837)2.68796308
49Abnormality of lateral ventricle (HP:0030047)2.68067726
50Diplopia (HP:0000651)2.67241083
51Abnormality of binocular vision (HP:0011514)2.67241083
52Acne (HP:0001061)2.67233397
53Impaired smooth pursuit (HP:0007772)2.64958191
54Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.64681130
55Abnormality of the nasal septum (HP:0000419)2.63832802
56Prominent nose (HP:0000448)2.59938223
57Abnormality of the pleura (HP:0002103)2.58392771
58Sparse scalp hair (HP:0002209)2.51096627
59Chronic otitis media (HP:0000389)2.49913381
60Myocardial infarction (HP:0001658)2.48697404
61Lip pit (HP:0100267)2.48670414
62Abnormality of the pericardium (HP:0001697)2.46343904
63Menstrual irregularities (HP:0000858)2.46082138
64Polyneuropathy (HP:0001271)2.45922040
65Oligodontia (HP:0000677)2.45202015
66Abnormality of cells of the erythroid lineage (HP:0012130)2.44549774
67Parakeratosis (HP:0001036)2.41186996
68Peritonitis (HP:0002586)2.38118297
69Glomerulopathy (HP:0100820)2.37346054
70Horizontal nystagmus (HP:0000666)2.30097677
71Esophageal varix (HP:0002040)2.29466637
72Lymphopenia (HP:0001888)2.28288025
73Abnormal number of erythroid precursors (HP:0012131)2.26811410
74Abnormality of cells of the lymphoid lineage (HP:0012140)2.25228460
75Cutaneous melanoma (HP:0012056)2.25113362
76Pancreatitis (HP:0001733)2.24164453
77Aplasia/Hypoplasia involving the musculature (HP:0001460)2.23790186
78Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.23495188
79Pulmonary embolism (HP:0002204)2.23007692
80Type I transferrin isoform profile (HP:0003642)2.21345365
81Agammaglobulinemia (HP:0004432)2.20599405
82Leukocytosis (HP:0001974)2.18228564
83Aplasia cutis congenita (HP:0001057)2.15670411
84Premature graying of hair (HP:0002216)2.15208392
85Hyperlipoproteinemia (HP:0010980)2.13772621
86Abnormality of the peritoneum (HP:0002585)2.13038189
87Vasculitis (HP:0002633)2.09522361
88Thrombophlebitis (HP:0004418)2.09487887
89Fetal akinesia sequence (HP:0001989)2.07855830
90Portal hypertension (HP:0001409)2.07024428
912-3 toe syndactyly (HP:0004691)2.05447247
92Polycythemia (HP:0001901)2.05317999
93Pancytopenia (HP:0001876)2.05308244
94Megalencephaly (HP:0001355)2.05113266
95Duplicated collecting system (HP:0000081)2.04066000
96Fatigue (HP:0012378)2.03720436
97Somatic mutation (HP:0001428)2.03587226
98Dysautonomia (HP:0002459)2.02402360
99Abnormality of T cell physiology (HP:0011840)2.00041554
100Abnormality of oral frenula (HP:0000190)1.99407124
101Increased intracranial pressure (HP:0002516)1.98009319
102Abnormality of intracranial pressure (HP:0012640)1.98009319
103Keratoconjunctivitis sicca (HP:0001097)1.97525445
104Decreased electroretinogram (ERG) amplitude (HP:0000654)1.97093287
105Amniotic constriction ring (HP:0009775)1.96429009
106Abnormality of placental membranes (HP:0011409)1.96429009
107Memory impairment (HP:0002354)1.95805711
108Fair hair (HP:0002286)1.95213864
109Gingival bleeding (HP:0000225)1.95153391
110Spontaneous abortion (HP:0005268)1.95012098
111Supranuclear gaze palsy (HP:0000605)1.93604408
112Abnormal protein glycosylation (HP:0012346)1.92409533
113Abnormal glycosylation (HP:0012345)1.92409533
114Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92409533
115Abnormal protein N-linked glycosylation (HP:0012347)1.92409533
116Meningitis (HP:0001287)1.91868240
117Conical tooth (HP:0000698)1.91771002
118Acrocyanosis (HP:0001063)1.91689250
119Hepatocellular necrosis (HP:0001404)1.91071952
120Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.90956066
121Subacute progressive viral hepatitis (HP:0006572)1.89053108
122Thoracolumbar scoliosis (HP:0002944)1.88944681
123Abnormality of saccadic eye movements (HP:0000570)1.87130899
124Abnormal number of incisors (HP:0011064)1.85504783
125Abnormality of eosinophils (HP:0001879)1.85105151
126Gangrene (HP:0100758)1.84164744
127Osteolytic defects of the hand bones (HP:0009699)1.82938152
128Osteolytic defects of the phalanges of the hand (HP:0009771)1.82938152
129Adactyly (HP:0009776)1.82637938
130Abnormality of the periventricular white matter (HP:0002518)1.82296786
131Abnormality of the hepatic vasculature (HP:0006707)1.82068813
132Abnormality of ocular smooth pursuit (HP:0000617)1.81520629
133Arthralgia (HP:0002829)1.79986896
134Encephalitis (HP:0002383)1.79428357
135Acute myeloid leukemia (HP:0004808)1.78607186
136Abnormality of the Achilles tendon (HP:0005109)1.78233439
137Generalized hypopigmentation of hair (HP:0011358)1.77883435
138Achilles tendon contracture (HP:0001771)1.77009695
139Abnormality of the renal collecting system (HP:0004742)1.76955384
140Thyroiditis (HP:0100646)1.76742596
141Orthostatic hypotension (HP:0001278)1.76596448
142Keratoconjunctivitis (HP:0001096)1.72469806
143Gaze-evoked nystagmus (HP:0000640)1.72385037
144Reduced subcutaneous adipose tissue (HP:0003758)1.71252066
145Abnormality of the pons (HP:0007361)1.70632218
146Abnormality of the clitoris (HP:0000056)1.70531045
147Cerebral ischemia (HP:0002637)1.69490092
148Molar tooth sign on MRI (HP:0002419)1.69412973
149Abnormality of midbrain morphology (HP:0002418)1.69412973
150Aseptic necrosis (HP:0010885)1.68289072
151Hypoproteinemia (HP:0003075)1.68122850
152IgM deficiency (HP:0002850)1.67617303
153Acute hepatic failure (HP:0006554)1.66997774
154Anhidrosis (HP:0000970)1.66983290
155Eosinophilia (HP:0001880)1.66197576
156Cerebral hemorrhage (HP:0001342)1.66027458
157Renal cortical cysts (HP:0000803)1.65529443
158Entropion (HP:0000621)1.64877143
159Vertigo (HP:0002321)1.64154124
160Neoplasm of the tracheobronchial system (HP:0100552)1.63032354
161Dyschromatopsia (HP:0007641)1.62109215
162Abnormality of iron homeostasis (HP:0011031)1.62049360
163Abnormality of the pubic bones (HP:0003172)1.61255847
164Hemoptysis (HP:0002105)1.59424256
165Abnormality of the common coagulation pathway (HP:0010990)1.58959560
166Hypoplasia of the thymus (HP:0000778)1.58908584

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK98.24750359
2TXK7.03805308
3MAP4K16.22020918
4ITK4.87263640
5PIM24.40132165
6ZAP703.25283665
7TEC3.09946743
8CDK32.78729866
9CSK2.68799374
10JAK32.51355703
11MAP3K142.40483297
12EEF2K2.31543510
13TAOK32.17987899
14NLK2.16062104
15EPHA32.07608292
16RAF11.86100222
17MATK1.84968511
18BTK1.77029409
19WNK41.71387366
20TAOK11.60981296
21ZAK1.60791476
22HCK1.56599228
23PIM11.49975657
24DAPK11.49133727
25LCK1.46275476
26CHUK1.44088600
27MAP2K61.42632410
28IKBKB1.40492760
29NTRK11.35593586
30FGFR41.35058151
31MAP4K21.34483741
32MAP3K31.31712228
33MST41.19887468
34MAP3K111.19555720
35PAK21.17782162
36STK101.13574327
37GSK3A1.12861880
38MAP3K71.12276133
39TYK21.12024060
40MAPK111.12016121
41SYK1.10521209
42CAMKK21.07552747
43PIK3CG1.04734504
44TBK11.03859331
45LRRK21.03793320
46TSSK61.02624336
47EIF2AK20.95498244
48RPS6KA40.94319735
49FGFR30.91573343
50LYN0.91367046
51IKBKE0.90322796
52PRKCH0.89352217
53RPS6KB20.85006037
54EIF2AK30.84647457
55MAP3K130.81434794
56ALK0.80026834
57STK390.79221449
58MST1R0.78559176
59CLK10.77676835
60NUAK10.76024142
61TLK10.75979208
62TRIB30.75137733
63ADRBK20.74259296
64INSR0.73364963
65TYRO30.72833496
66PINK10.72443346
67FGFR10.71346240
68IRAK10.67134653
69MAP2K20.63849268
70NTRK20.63797666
71FES0.63661516
72GRK70.59760788
73PRKCQ0.59508211
74JAK10.58669054
75PRKCG0.57918561
76TAOK20.57776099
77MAP3K120.57514489
78PIK3CA0.57058542
79ACVR1B0.56912355
80MAP3K10.56149121
81NEK10.54760846
82FER0.54116966
83VRK20.53040175
84CSNK1D0.52727444
85YES10.52600277
86PHKG20.52183416
87PHKG10.52183416
88EGFR0.52080984
89FRK0.51466502
90IGF1R0.50063378
91NME10.48227063
92MAPK70.47798924
93KIT0.46977914
94JAK20.46405362
95MARK30.45746379
96MAP3K80.44100776
97MARK20.43384625
98PASK0.42504153
99MUSK0.40182835
100MAP2K30.39239455
101ERN10.38791644
102ROCK20.37053331
103CAMKK10.36927834
104RPS6KA10.36289666
105MAP3K50.35878289
106NME20.34308857
107RPS6KA50.34031807
108EIF2AK10.33973320
109PTK60.33294338
110MAP3K90.32766107
111PRKCE0.32680031
112CSNK1A1L0.31745812
113MAP3K20.30749888
114MAPKAPK20.30688691
115MAP3K100.30107166
116BMPR20.29793230
117FYN0.29720764
118IRAK40.29535868
119FGFR20.29047611
120CDK40.28275735
121MELK0.28153705
122RPS6KB10.27332050
123CSNK1G20.27209173
124TGFBR10.27198900
125MAPKAPK30.27170270
126EPHB10.26724746
127PRKCB0.26455775
128PKN10.25995520
129NEK60.25798817
130TGFBR20.25058098
131PDK10.24756946
132SRPK10.24722309
133BMX0.24208633
134PRKD10.23976844
135PDGFRB0.22506218
136KDR0.22264540
137ABL10.20462007
138MAPK90.17934898
139TNK20.17272444
140CSF1R0.16202021
141CDK190.16048226
142CSNK1G30.15976065
143GRK60.15393805
144CSNK2A20.14954413
145HIPK20.13330894
146WNK10.11475298
147CSNK1A10.09625538

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053328.68368866
2Type I diabetes mellitus_Homo sapiens_hsa049405.43035997
3Allograft rejection_Homo sapiens_hsa053304.78969747
4Asthma_Homo sapiens_hsa053103.50850455
5T cell receptor signaling pathway_Homo sapiens_hsa046603.27379922
6Antigen processing and presentation_Homo sapiens_hsa046123.18157746
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.02639243
8Hematopoietic cell lineage_Homo sapiens_hsa046402.70363361
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.70332331
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.68847087
11One carbon pool by folate_Homo sapiens_hsa006702.55345011
12Proteasome_Homo sapiens_hsa030502.36687443
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.15275692
14Autoimmune thyroid disease_Homo sapiens_hsa053202.12926055
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.11224129
16Jak-STAT signaling pathway_Homo sapiens_hsa046302.09475994
17Primary immunodeficiency_Homo sapiens_hsa053401.84947420
18* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.79961425
19Measles_Homo sapiens_hsa051621.76245555
20Basal transcription factors_Homo sapiens_hsa030221.73261692
21TNF signaling pathway_Homo sapiens_hsa046681.54736499
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.52145845
23Rheumatoid arthritis_Homo sapiens_hsa053231.44751269
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.40600619
25Protein export_Homo sapiens_hsa030601.32942452
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.30449659
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30045735
28Leishmaniasis_Homo sapiens_hsa051401.25209368
29HTLV-I infection_Homo sapiens_hsa051661.15073141
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.14520639
31Salmonella infection_Homo sapiens_hsa051321.09693991
32Amoebiasis_Homo sapiens_hsa051461.06774159
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01626671
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01431213
35African trypanosomiasis_Homo sapiens_hsa051431.00840957
36Osteoclast differentiation_Homo sapiens_hsa043801.00112186
37Linoleic acid metabolism_Homo sapiens_hsa005910.99865725
38Herpes simplex infection_Homo sapiens_hsa051680.92456289
39SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92228747
40N-Glycan biosynthesis_Homo sapiens_hsa005100.92198924
41Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92102078
42Pyrimidine metabolism_Homo sapiens_hsa002400.85857566
43Malaria_Homo sapiens_hsa051440.84839462
44Non-homologous end-joining_Homo sapiens_hsa034500.81340214
45Homologous recombination_Homo sapiens_hsa034400.81315500
46Toxoplasmosis_Homo sapiens_hsa051450.77772161
47Circadian rhythm_Homo sapiens_hsa047100.77749212
48Apoptosis_Homo sapiens_hsa042100.75488670
49Regulation of autophagy_Homo sapiens_hsa041400.74708987
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72200935
51* Chemokine signaling pathway_Homo sapiens_hsa040620.71799872
52Purine metabolism_Homo sapiens_hsa002300.67525501
53Acute myeloid leukemia_Homo sapiens_hsa052210.65862699
54Phototransduction_Homo sapiens_hsa047440.64833135
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64010000
56ABC transporters_Homo sapiens_hsa020100.62188509
57Ribosome_Homo sapiens_hsa030100.60658948
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58642602
59Fatty acid elongation_Homo sapiens_hsa000620.56173366
60Sulfur metabolism_Homo sapiens_hsa009200.55723617
61Hepatitis B_Homo sapiens_hsa051610.54396322
62B cell receptor signaling pathway_Homo sapiens_hsa046620.54337473
63Systemic lupus erythematosus_Homo sapiens_hsa053220.52941976
64Fatty acid metabolism_Homo sapiens_hsa012120.52761562
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52259701
66Prolactin signaling pathway_Homo sapiens_hsa049170.51697831
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51582636
68Tuberculosis_Homo sapiens_hsa051520.51073416
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51011125
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50903572
71Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50866645
72Legionellosis_Homo sapiens_hsa051340.50113234
73Chronic myeloid leukemia_Homo sapiens_hsa052200.49738716
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49243424
75Pertussis_Homo sapiens_hsa051330.49156691
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47352562
77Glycerolipid metabolism_Homo sapiens_hsa005610.46054540
78Oxidative phosphorylation_Homo sapiens_hsa001900.46039441
79Dorso-ventral axis formation_Homo sapiens_hsa043200.45542703
80Chemical carcinogenesis_Homo sapiens_hsa052040.45261811
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45093583
82Viral myocarditis_Homo sapiens_hsa054160.44632230
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.43499836
84Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43035046
85Viral carcinogenesis_Homo sapiens_hsa052030.42918136
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42096106
87Tryptophan metabolism_Homo sapiens_hsa003800.41729291
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.38786590
89Small cell lung cancer_Homo sapiens_hsa052220.38648534
90Ether lipid metabolism_Homo sapiens_hsa005650.38133287
91Epstein-Barr virus infection_Homo sapiens_hsa051690.37907409
92Thyroid cancer_Homo sapiens_hsa052160.37379505
93Fat digestion and absorption_Homo sapiens_hsa049750.37120985
94RNA degradation_Homo sapiens_hsa030180.36480536
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35595159
96Nucleotide excision repair_Homo sapiens_hsa034200.35029491
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34124857
98Butanoate metabolism_Homo sapiens_hsa006500.34050929
99Nitrogen metabolism_Homo sapiens_hsa009100.32090691
100Influenza A_Homo sapiens_hsa051640.30972037
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30640436
102Fructose and mannose metabolism_Homo sapiens_hsa000510.29837827
103MAPK signaling pathway_Homo sapiens_hsa040100.29794206
104Biosynthesis of amino acids_Homo sapiens_hsa012300.26059220
105MicroRNAs in cancer_Homo sapiens_hsa052060.24289019
106Hepatitis C_Homo sapiens_hsa051600.24107688
107Shigellosis_Homo sapiens_hsa051310.24037404
108Parkinsons disease_Homo sapiens_hsa050120.23873054
109Pentose phosphate pathway_Homo sapiens_hsa000300.22710602
110Staphylococcus aureus infection_Homo sapiens_hsa051500.22226990
111Cysteine and methionine metabolism_Homo sapiens_hsa002700.19493612
112TGF-beta signaling pathway_Homo sapiens_hsa043500.19457746
113Platelet activation_Homo sapiens_hsa046110.18411759
114VEGF signaling pathway_Homo sapiens_hsa043700.18402723
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.16717331
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.16626729
117Arachidonic acid metabolism_Homo sapiens_hsa005900.15850086
118mTOR signaling pathway_Homo sapiens_hsa041500.14844863
119Renin-angiotensin system_Homo sapiens_hsa046140.14322441
120Ras signaling pathway_Homo sapiens_hsa040140.14309082
121Cocaine addiction_Homo sapiens_hsa050300.14279827
122Colorectal cancer_Homo sapiens_hsa052100.14086107
123Morphine addiction_Homo sapiens_hsa050320.13835181
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13526983
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.13036932
126ErbB signaling pathway_Homo sapiens_hsa040120.12054353
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.11559220
128Pancreatic cancer_Homo sapiens_hsa052120.11048478
129PI3K-Akt signaling pathway_Homo sapiens_hsa041510.10452655
130Type II diabetes mellitus_Homo sapiens_hsa049300.09551998
131Insulin resistance_Homo sapiens_hsa049310.09402997
132Proteoglycans in cancer_Homo sapiens_hsa052050.08253342
133Renin secretion_Homo sapiens_hsa049240.08120618
134Olfactory transduction_Homo sapiens_hsa047400.07354633
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.07046877
136Bladder cancer_Homo sapiens_hsa052190.05471471
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.03163900
138Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.02722250
139Caffeine metabolism_Homo sapiens_hsa002320.02658454
140RNA polymerase_Homo sapiens_hsa030200.02568935
141HIF-1 signaling pathway_Homo sapiens_hsa040660.02080089
142Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.00787238
143Primary bile acid biosynthesis_Homo sapiens_hsa001200.00741628
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.0412308
145Endometrial cancer_Homo sapiens_hsa05213-0.0379754
146p53 signaling pathway_Homo sapiens_hsa04115-0.0358648
147Endocytosis_Homo sapiens_hsa04144-0.0340619
148Non-small cell lung cancer_Homo sapiens_hsa05223-0.0333425
149Spliceosome_Homo sapiens_hsa03040-0.0207607
150RNA transport_Homo sapiens_hsa03013-0.0026946
151Rap1 signaling pathway_Homo sapiens_hsa04015-0.0011926

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