XCL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of T cell mediated immunity (GO:0002710)9.97837736
2negative regulation of interleukin-2 production (GO:0032703)8.39260860
3interferon-gamma production (GO:0032609)8.29064161
4regulation of RIG-I signaling pathway (GO:0039535)8.00107133
5positive regulation of T-helper 1 type immune response (GO:0002827)7.96662982
6lymphocyte chemotaxis (GO:0048247)7.73740103
7positive regulation of type 2 immune response (GO:0002830)7.47479464
8regulation of lymphocyte chemotaxis (GO:1901623)7.34279463
9regulation of T cell cytokine production (GO:0002724)7.20851726
10positive regulation of transforming growth factor beta production (GO:0071636)7.17292458
11regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)7.05148351
12positive regulation of T cell mediated cytotoxicity (GO:0001916)6.75430562
13regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00436.74775342
14positive regulation of alpha-beta T cell proliferation (GO:0046641)6.47080741
15negative regulation of cytokine production involved in immune response (GO:0002719)6.32291001
16positive regulation of leukocyte mediated cytotoxicity (GO:0001912)6.28615814
17regulation of T-helper 1 type immune response (GO:0002825)6.15941092
18positive regulation of hormone biosynthetic process (GO:0046886)6.14967346
19negative regulation of alpha-beta T cell activation (GO:0046636)6.04128586
20cellular response to interleukin-4 (GO:0071353)5.95229451
21regulation of T cell mediated cytotoxicity (GO:0001914)5.82517540
22positive regulation of cell killing (GO:0031343)5.58206208
23positive regulation of neutrophil migration (GO:1902624)5.53600749
24positive regulation of neutrophil chemotaxis (GO:0090023)5.53600749
25negative regulation of production of molecular mediator of immune response (GO:0002701)5.44294277
26regulation of leukocyte mediated cytotoxicity (GO:0001910)5.44090126
27negative regulation of lymphocyte mediated immunity (GO:0002707)5.41050978
28positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.28908378
29regulation of alpha-beta T cell proliferation (GO:0046640)5.21101624
30positive regulation of natural killer cell mediated immunity (GO:0002717)5.14652348
31negative regulation of adaptive immune response based on somatic recombination of immune receptors b5.12203200
32response to interleukin-4 (GO:0070670)4.97732216
33positive regulation of T cell migration (GO:2000406)4.96461730
34positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)4.93679300
35negative regulation of heart rate (GO:0010459)4.93320427
36positive regulation of granulocyte chemotaxis (GO:0071624)4.92562940
37regulation of cell killing (GO:0031341)4.86064169
38positive regulation of lymphocyte migration (GO:2000403)4.78808538
39lymphocyte migration (GO:0072676)4.75785228
40activated T cell proliferation (GO:0050798)4.68077781
41negative regulation of adaptive immune response (GO:0002820)4.55429208
42positive regulation of hormone metabolic process (GO:0032352)4.53296090
43positive regulation of immunoglobulin mediated immune response (GO:0002891)4.51483089
44positive regulation of B cell mediated immunity (GO:0002714)4.51483089
45positive regulation of interleukin-10 production (GO:0032733)4.47525909
46positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)4.42210961
47positive regulation of fibroblast migration (GO:0010763)4.40803404
48positive regulation of immunoglobulin production (GO:0002639)4.33397039
49positive regulation of glycolytic process (GO:0045821)4.31546129
50regulation of natural killer cell mediated immunity (GO:0002715)4.27049476
51regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.27049476
52regulation of neutrophil chemotaxis (GO:0090022)4.26298891
53regulation of neutrophil migration (GO:1902622)4.26298891
54regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)4.25562819
55regulation of T cell migration (GO:2000404)4.24294487
56mRNA cleavage (GO:0006379)4.23070653
57positive regulation of T cell mediated immunity (GO:0002711)4.20772327
58cellular response to interleukin-15 (GO:0071350)4.15775525
59positive regulation of protein sumoylation (GO:0033235)4.14803398
60regulation of type 2 immune response (GO:0002828)4.13181092
61negative regulation of leukocyte mediated immunity (GO:0002704)4.07591427
62mRNA transcription from RNA polymerase II promoter (GO:0042789)4.01841118
63response to interleukin-15 (GO:0070672)3.94903953
64regulation of transforming growth factor beta production (GO:0071634)3.81082808
65negative regulation of sequestering of calcium ion (GO:0051283)3.75959173
66release of sequestered calcium ion into cytosol (GO:0051209)3.75959173
67regulation of glomerular filtration (GO:0003093)3.68655362
68L-fucose catabolic process (GO:0042355)3.63356038
69fucose catabolic process (GO:0019317)3.63356038
70L-fucose metabolic process (GO:0042354)3.63356038
71positive regulation of lymphocyte mediated immunity (GO:0002708)3.60756063
72regulation of interleukin-2 production (GO:0032663)3.60435758
73positive regulation of cytokine production involved in immune response (GO:0002720)3.52428930
74NIK/NF-kappaB signaling (GO:0038061)3.51345997
75regulation of lymphocyte migration (GO:2000401)3.48874872
76regulation of sequestering of calcium ion (GO:0051282)3.46485940
77positive regulation of gamma-delta T cell activation (GO:0046645)3.45386192
78mRNA transcription (GO:0009299)3.37519269
79regulation of T cell mediated immunity (GO:0002709)3.35875082
80regulation of immunoglobulin mediated immune response (GO:0002889)3.34960914
81negative regulation of interferon-gamma production (GO:0032689)3.34238383
82cellular response to nicotine (GO:0071316)3.32596482
83regulation of interleukin-10 production (GO:0032653)3.32070563
84pyrimidine ribonucleoside catabolic process (GO:0046133)3.29473648
85mast cell degranulation (GO:0043303)3.28469253
86mast cell activation involved in immune response (GO:0002279)3.28469253
87regulation of gamma-delta T cell differentiation (GO:0045586)3.27892308
88regulation of B cell mediated immunity (GO:0002712)3.23531439
89regulation of immunoglobulin production (GO:0002637)3.22647625
90nerve growth factor signaling pathway (GO:0038180)3.19423391
91cytidine metabolic process (GO:0046087)3.17081349
92cytidine catabolic process (GO:0006216)3.17081349
93cytidine deamination (GO:0009972)3.17081349
94regulation of granulocyte chemotaxis (GO:0071622)3.14612078
95positive regulation of erythrocyte differentiation (GO:0045648)3.13948008
96DNA deamination (GO:0045006)3.11574328
97negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)11.1810950
98positive regulation of T cell cytokine production (GO:0002726)11.1411497
99regulation of T cell chemotaxis (GO:0010819)10.3542423
100positive regulation of T cell chemotaxis (GO:0010820)10.3542423

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.47427192
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human5.99355505
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.18425162
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.99496980
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.50689358
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.42751444
7FLI1_27457419_Chip-Seq_LIVER_Mouse3.83869404
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.67973647
9PCGF2_27294783_Chip-Seq_ESCs_Mouse3.42446332
10PCGF2_27294783_Chip-Seq_NPCs_Mouse3.13614853
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.09872006
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.84210989
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.74312507
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.72401798
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.57032260
16VDR_22108803_ChIP-Seq_LS180_Human2.53715964
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.50909618
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.24147477
19ZNF274_21170338_ChIP-Seq_K562_Hela2.15477715
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.13567945
21SUZ12_27294783_Chip-Seq_NPCs_Mouse2.11015575
22NFE2_27457419_Chip-Seq_LIVER_Mouse1.99456840
23LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89048131
24* MYB_26560356_Chip-Seq_TH2_Human1.74904907
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.70527356
26IRF1_19129219_ChIP-ChIP_H3396_Human1.69896044
27RUNX_20019798_ChIP-Seq_JUKART_Human1.62202991
28VDR_23849224_ChIP-Seq_CD4+_Human1.60102524
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.57078617
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55581758
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.55283042
32EZH2_27294783_Chip-Seq_NPCs_Mouse1.54368097
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.53544289
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51538832
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.37883078
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.37758466
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.33061194
38FOXP3_21729870_ChIP-Seq_TREG_Human1.25928687
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.24168715
40* GATA3_26560356_Chip-Seq_TH2_Human1.22703555
41CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.21986985
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18073814
43CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15918569
44MYB_26560356_Chip-Seq_TH1_Human1.13858575
45DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13216331
46GATA3_27048872_Chip-Seq_THYMUS_Human1.10280997
47OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07623307
48MAF_26560356_Chip-Seq_TH1_Human1.05543161
49MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05436107
50ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04667726
51GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04378791
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03093888
53SPI1_23547873_ChIP-Seq_NB4_Human1.03033433
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02636131
55CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02133018
56ETS1_20019798_ChIP-Seq_JURKAT_Human1.02001492
57MAF_26560356_Chip-Seq_TH2_Human1.01076544
58CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00975341
59CRX_20693478_ChIP-Seq_RETINA_Mouse1.00265736
60OCT4_18555785_Chip-Seq_ESCs_Mouse0.94722039
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94537032
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91256557
63SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89667434
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.89570594
65EGR1_19032775_ChIP-ChIP_M12_Human0.89307337
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.87629295
67SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.87228111
68CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87178123
69EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.86826227
70NMYC_18555785_Chip-Seq_ESCs_Mouse0.86167421
71GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86012630
72P300_18555785_Chip-Seq_ESCs_Mouse0.85487195
73ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85460534
74* RBPJ_21746931_ChIP-Seq_IB4_Human0.84981133
75SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.82551987
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.82141723
77FOXH1_21741376_ChIP-Seq_EPCs_Human0.81038830
78MYB_21317192_ChIP-Seq_ERMYB_Mouse0.80121784
79HOXB7_26014856_ChIP-Seq_BT474_Human0.79080490
80STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.78834323
81GATA2_21666600_ChIP-Seq_HMVEC_Human0.78798322
82P53_22387025_ChIP-Seq_ESCs_Mouse0.78185711
83* GATA6_21074721_ChIP-Seq_CACO-2_Human0.78076381
84SUZ12_18555785_Chip-Seq_ESCs_Mouse0.77144568
85MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.76967693
86SMAD1_18555785_Chip-Seq_ESCs_Mouse0.76883332
87KLF4_18555785_Chip-Seq_ESCs_Mouse0.76812930
88FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.75824265
89* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73911905
90STAT3_18555785_Chip-Seq_ESCs_Mouse0.73068400
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.72999390
92SRF_21415370_ChIP-Seq_HL-1_Mouse0.72578078
93ZFX_18555785_Chip-Seq_ESCs_Mouse0.72125868
94MYC_18940864_ChIP-ChIP_HL60_Human0.71625464
95CTCF_18555785_Chip-Seq_ESCs_Mouse0.71598730
96UTX_26944678_Chip-Seq_JUKART_Human0.70326750
97MYC_19829295_ChIP-Seq_ESCs_Human0.70264236
98NANOG_20526341_ChIP-Seq_ESCs_Human0.69591167
99TP53_22573176_ChIP-Seq_HFKS_Human0.68981395
100EGR1_23403033_ChIP-Seq_LIVER_Mouse0.68629976

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002006_tumorigenesis4.79319110
2MP0005310_abnormal_salivary_gland4.21286519
3MP0005671_abnormal_response_to3.88358353
4MP0001790_abnormal_immune_system3.87279711
5MP0005387_immune_system_phenotype3.87279711
6MP0009333_abnormal_splenocyte_physiolog3.56338375
7MP0003303_peritoneal_inflammation3.26773336
8MP0004381_abnormal_hair_follicle3.20938025
9MP0000372_irregular_coat_pigmentation3.01982970
10MP0005000_abnormal_immune_tolerance2.69228265
11MP0003763_abnormal_thymus_physiology2.63165175
12MP0001800_abnormal_humoral_immune2.48482495
13MP0002138_abnormal_hepatobiliary_system2.45563549
14MP0005075_abnormal_melanosome_morpholog2.31913318
15MP0002723_abnormal_immune_serum2.21391183
16MP0003448_altered_tumor_morphology2.15211906
17MP0003724_increased_susceptibility_to2.14996452
18MP0000685_abnormal_immune_system2.11322396
19MP0002420_abnormal_adaptive_immunity2.10971351
20MP0001835_abnormal_antigen_presentation2.05054524
21MP0001819_abnormal_immune_cell2.04560593
22MP0001853_heart_inflammation1.91419657
23MP0002452_abnormal_antigen_presenting1.90719305
24MP0004947_skin_inflammation1.81480038
25MP0003646_muscle_fatigue1.79839428
26MP0004510_myositis1.77173571
27MP0006082_CNS_inflammation1.74967009
28MP0003436_decreased_susceptibility_to1.72587746
29MP0001873_stomach_inflammation1.71202011
30MP0005451_abnormal_body_composition1.71056703
31MP0005025_abnormal_response_to1.70117258
32MP0000613_abnormal_salivary_gland1.69485207
33MP0001881_abnormal_mammary_gland1.66748589
34MP0001502_abnormal_circadian_rhythm1.61746162
35MP0003786_premature_aging1.61445927
36MP0002166_altered_tumor_susceptibility1.61432520
37MP0002398_abnormal_bone_marrow1.56854636
38MP0009785_altered_susceptibility_to1.55156980
39MP0002796_impaired_skin_barrier1.51189096
40MP0003866_abnormal_defecation1.49440163
41MP0000716_abnormal_immune_system1.48236395
42MP0002396_abnormal_hematopoietic_system1.46854251
43MP0001845_abnormal_inflammatory_respons1.40596158
44MP0000689_abnormal_spleen_morphology1.35902313
45MP0006276_abnormal_autonomic_nervous1.35770597
46MP0002254_reproductive_system_inflammat1.35507959
47MP0008260_abnormal_autophagy1.34590193
48MP0002722_abnormal_immune_system1.34055393
49MP0000703_abnormal_thymus_morphology1.31675115
50MP0002419_abnormal_innate_immunity1.31346221
51MP0002148_abnormal_hypersensitivity_rea1.30868614
52MP0003453_abnormal_keratinocyte_physiol1.30039268
53MP0001958_emphysema1.29006301
54MP0002429_abnormal_blood_cell1.24450433
55MP0005085_abnormal_gallbladder_physiolo1.24191176
56MP0001501_abnormal_sleep_pattern1.21335383
57MP0002405_respiratory_system_inflammati1.20258595
58MP0008469_abnormal_protein_level1.17670639
59MP0000627_abnormal_mammary_gland1.16070150
60MP0003045_fibrosis1.10211134
61MP0002653_abnormal_ependyma_morphology1.09818464
62MP0000013_abnormal_adipose_tissue1.07663183
63MP0006035_abnormal_mitochondrial_morpho1.07501603
64MP0000358_abnormal_cell_content/1.06573482
65MP0000609_abnormal_liver_physiology1.00550821
66MP0002136_abnormal_kidney_physiology1.00528486
67MP0000569_abnormal_digit_pigmentation0.96280138
68MP0010155_abnormal_intestine_physiology0.96092268
69MP0009763_increased_sensitivity_to0.90679134
70MP0008872_abnormal_physiological_respon0.87785683
71MP0002877_abnormal_melanocyte_morpholog0.87437618
72MP0001661_extended_life_span0.85969386
73MP0004484_altered_response_of0.85221703
74MP0000015_abnormal_ear_pigmentation0.84335119
75MP0003172_abnormal_lysosome_physiology0.84280467
76MP0006036_abnormal_mitochondrial_physio0.81968667
77MP0004142_abnormal_muscle_tone0.81815335
78MP0000749_muscle_degeneration0.81778049
79MP0003936_abnormal_reproductive_system0.78226653
80MP0003959_abnormal_lean_body0.77712311
81MP0002019_abnormal_tumor_incidence0.76994893
82MP0002970_abnormal_white_adipose0.74982168
83MP0002971_abnormal_brown_adipose0.72736621
84MP0001533_abnormal_skeleton_physiology0.71857537
85MP0002909_abnormal_adrenal_gland0.68140454
86MP0004742_abnormal_vestibular_system0.66919076
87MP0002132_abnormal_respiratory_system0.60568982
88MP0005501_abnormal_skin_physiology0.59799251
89MP0001663_abnormal_digestive_system0.59010743
90MP0002933_joint_inflammation0.54615486
91MP0001664_abnormal_digestion0.53387398
92MP0003693_abnormal_embryo_hatching0.53178183
93MP0005332_abnormal_amino_acid0.53050518
94MP0003828_pulmonary_edema0.52319317
95MP0002067_abnormal_sensory_capabilities0.52133981
96MP0009745_abnormal_behavioral_response0.51928419
97MP0005452_abnormal_adipose_tissue0.51597140
98MP0005167_abnormal_blood-brain_barrier0.50016455
99MP0002163_abnormal_gland_morphology0.47654578
100MP0005551_abnormal_eye_electrophysiolog0.46264986

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)9.14714134
2Optic neuritis (HP:0100653)9.14714134
3Orchitis (HP:0100796)8.03874710
4Myositis (HP:0100614)7.20072315
5Keratoconjunctivitis sicca (HP:0001097)6.17258341
6Abnormality of the labia minora (HP:0012880)5.97611306
7Keratoconjunctivitis (HP:0001096)5.71999019
83-Methylglutaconic aciduria (HP:0003535)4.79308660
9Encephalitis (HP:0002383)4.65026215
10Slow saccadic eye movements (HP:0000514)4.55041643
11Keratitis (HP:0000491)3.94490410
12Abnormal delayed hypersensitivity skin test (HP:0002963)3.85136855
13Pulmonary infiltrates (HP:0002113)3.79854145
14Hypoproteinemia (HP:0003075)3.65024081
15T lymphocytopenia (HP:0005403)3.52073446
16Recurrent cutaneous fungal infections (HP:0011370)3.41508959
17Chronic mucocutaneous candidiasis (HP:0002728)3.41508959
18Hypoplastic ischia (HP:0003175)3.33880144
19Gangrene (HP:0100758)3.28086646
20Arterial thrombosis (HP:0004420)3.25960130
21Orthostatic hypotension (HP:0001278)3.18448579
22Abnormality of T cell number (HP:0011839)3.16571440
23Hemoptysis (HP:0002105)3.14417416
24Impaired smooth pursuit (HP:0007772)3.00499426
25Anorexia (HP:0002039)2.94470833
26Panhypogammaglobulinemia (HP:0003139)2.93186831
27Abnormality of T cells (HP:0002843)2.90811157
28Abnormality of lateral ventricle (HP:0030047)2.82893563
29Pulmonary embolism (HP:0002204)2.80929050
30Sparse scalp hair (HP:0002209)2.80387119
31Dysautonomia (HP:0002459)2.79725324
32Abnormality of the ischium (HP:0003174)2.76216957
33Congenital stationary night blindness (HP:0007642)2.72144372
34IgG deficiency (HP:0004315)2.63866091
35Abnormality of saccadic eye movements (HP:0000570)2.55680303
36Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.55522433
37Hypoplastic nipples (HP:0002557)2.53932403
38Abnormality of midbrain morphology (HP:0002418)2.53658090
39Molar tooth sign on MRI (HP:0002419)2.53658090
40Acne (HP:0001061)2.52249119
41Arthropathy (HP:0003040)2.49842367
42Prominent nose (HP:0000448)2.46835630
43Meningitis (HP:0001287)2.46076021
44Cerebral hypomyelination (HP:0006808)2.44994219
45Abnormality of the endocardium (HP:0004306)2.41905446
46Abnormality of the clitoris (HP:0000056)2.38969786
47Abnormality of T cell physiology (HP:0011840)2.38301965
48Clitoromegaly (HP:0000057)2.38287955
49Anhidrosis (HP:0000970)2.37582262
50Abnormality of the pleura (HP:0002103)2.30888052
51Chronic diarrhea (HP:0002028)2.21454199
52Agammaglobulinemia (HP:0004432)2.19289585
53Genetic anticipation (HP:0003743)2.18328926
54Menstrual irregularities (HP:0000858)2.18185044
55Abnormality of oral frenula (HP:0000190)2.16486239
56Vasculitis (HP:0002633)2.14252681
57Dyschromatopsia (HP:0007641)2.12242837
58Abnormality of placental membranes (HP:0011409)2.10832292
59Amniotic constriction ring (HP:0009775)2.10832292
60Gaze-evoked nystagmus (HP:0000640)2.09726560
61Abnormality of the labia (HP:0000058)2.09049950
62Decreased electroretinogram (ERG) amplitude (HP:0000654)2.09007270
63Oligodactyly (hands) (HP:0001180)2.05785441
64Abnormality of the pericardium (HP:0001697)2.05667317
65Horizontal nystagmus (HP:0000666)2.04634860
66Fetal akinesia sequence (HP:0001989)2.01185958
67Abnormality of ocular smooth pursuit (HP:0000617)2.00068846
68Type I transferrin isoform profile (HP:0003642)1.98694662
69Supranuclear gaze palsy (HP:0000605)1.98668721
70Aplasia/Hypoplasia involving the musculature (HP:0001460)1.97588435
71Recurrent fungal infections (HP:0002841)1.95162566
72Recurrent corneal erosions (HP:0000495)1.94332371
73Tubular atrophy (HP:0000092)1.92808757
74Joint swelling (HP:0001386)1.92671687
75Progressive external ophthalmoplegia (HP:0000590)1.91396997
76Oligodontia (HP:0000677)1.90608356
77Pheochromocytoma (HP:0002666)1.90428770
78Hyperlipoproteinemia (HP:0010980)1.89063156
79Severe combined immunodeficiency (HP:0004430)1.88865362
80Polyneuropathy (HP:0001271)1.88783891
81Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.87718401
82Abnormality of intracranial pressure (HP:0012640)1.86938668
83Increased intracranial pressure (HP:0002516)1.86938668
84Short tibia (HP:0005736)1.85056655
85Cutaneous melanoma (HP:0012056)1.82898630
86Pancreatitis (HP:0001733)1.82042721
87Glomerulopathy (HP:0100820)1.81636853
88Abnormality of DNA repair (HP:0003254)1.78713278
89Microvesicular hepatic steatosis (HP:0001414)1.77971886
90Autoamputation (HP:0001218)1.77623858
91Abnormal protein glycosylation (HP:0012346)1.76994201
92Abnormal glycosylation (HP:0012345)1.76994201
93Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.76994201
94Abnormal protein N-linked glycosylation (HP:0012347)1.76994201
95Mediastinal lymphadenopathy (HP:0100721)1.76563400
96Neuroendocrine neoplasm (HP:0100634)1.72964362
97Chorioretinal atrophy (HP:0000533)1.70359779
98Fair hair (HP:0002286)1.70206729
99Aplasia/Hypoplasia of the tibia (HP:0005772)1.69972073
100Thrombophlebitis (HP:0004418)1.68643626

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK96.07161967
2FES4.68750707
3TAOK14.07342932
4MAP3K113.94732473
5MAPKAPK33.83674440
6TAOK23.72533899
7NTRK13.57243358
8NLK3.55073463
9MATK3.23752677
10MAP3K33.19834842
11MAP2K33.17733167
12TXK2.90526790
13CSK1.92694986
14DAPK11.80422695
15SRPK11.79024411
16MAP4K11.77395215
17JAK31.76498292
18ALK1.59962496
19TSSK61.59198414
20TLK11.57127333
21FER1.47418022
22TAOK31.42943304
23EPHA31.41819692
24MAP3K11.36732160
25PIK3CG1.15458157
26TYRO31.12762289
27PINK11.10346427
28MAP2K61.08446699
29LCK0.95846450
30CSNK1A1L0.94102534
31CAMKK20.92237059
32CSNK1G30.91455174
33MAP3K50.90028279
34EPHB10.88842369
35CSNK1G20.88224345
36MAPK110.87528175
37FGFR40.86903160
38PRKCQ0.85307634
39MAPKAPK20.84667944
40WNK40.82596736
41MAP3K140.79506925
42GRK70.75877113
43MAP3K120.73457485
44NME10.73317461
45ITK0.70962336
46ZAK0.67164730
47SYK0.66633320
48PHKG20.66344304
49PHKG10.66344304
50BTK0.63372786
51ADRBK20.59859928
52IKBKB0.58102930
53MAP4K20.57912727
54CSNK1G10.57705277
55EIF2AK30.56177824
56EIF2AK20.55852927
57ERN10.54041689
58ERBB20.52818562
59CLK10.52310905
60JAK10.51193568
61NUAK10.50012758
62YES10.49180179
63CAMKK10.48475597
64IKBKE0.46765029
65LYN0.43435502
66PIK3CA0.42770241
67KIT0.42317709
68TGFBR20.41430028
69HCK0.39002265
70INSR0.38532434
71MARK30.38422659
72IRAK10.33546641
73DMPK0.32583954
74VRK20.30577472
75PTK2B0.26362994
76JAK20.25220269
77RPS6KB10.24506024
78IGF1R0.24207495
79NEK10.22735794
80CAMK2D0.20798825
81CHEK20.20655938
82PDGFRB0.20076496
83FGFR30.19936470
84CSF1R0.19308568
85ACVR1B0.19034423
86STK100.18944127
87CAMK2G0.18319424
88PTK60.16716135
89BUB10.16388300
90GRK60.16351710
91CSNK2A10.15953694
92TNK20.14491737
93EIF2AK10.14326390
94CSNK1D0.13951975
95CHUK0.13044337
96ATR0.12931480
97CSNK1E0.12770503
98GSK3A0.12512077
99PRKCH0.12061160
100TBK10.12000193

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.73022533
2Antigen processing and presentation_Homo sapiens_hsa046124.11002856
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.98065594
4Graft-versus-host disease_Homo sapiens_hsa053323.57947600
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.26817097
6One carbon pool by folate_Homo sapiens_hsa006703.04075693
7RNA polymerase_Homo sapiens_hsa030202.86430021
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.76244419
9Allograft rejection_Homo sapiens_hsa053302.59270910
10Proteasome_Homo sapiens_hsa030502.56358246
11T cell receptor signaling pathway_Homo sapiens_hsa046602.55675631
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.47452200
13Autoimmune thyroid disease_Homo sapiens_hsa053202.39785319
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.28343622
15Jak-STAT signaling pathway_Homo sapiens_hsa046302.23404522
16* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040602.22436991
17Malaria_Homo sapiens_hsa051442.09733988
18Type I diabetes mellitus_Homo sapiens_hsa049402.00107657
19Measles_Homo sapiens_hsa051621.73447762
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.70539288
21Regulation of autophagy_Homo sapiens_hsa041401.57620062
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.52680536
23Chemical carcinogenesis_Homo sapiens_hsa052041.32061680
24Basal transcription factors_Homo sapiens_hsa030221.28674073
25Renal cell carcinoma_Homo sapiens_hsa052111.28562141
26Protein export_Homo sapiens_hsa030601.22991149
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19876120
28Linoleic acid metabolism_Homo sapiens_hsa005911.16929875
29* Chemokine signaling pathway_Homo sapiens_hsa040621.13164424
30Caffeine metabolism_Homo sapiens_hsa002321.08796051
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.04167915
32Apoptosis_Homo sapiens_hsa042101.02454243
33Thyroid cancer_Homo sapiens_hsa052161.01393939
34SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99720124
35N-Glycan biosynthesis_Homo sapiens_hsa005100.99174704
36Purine metabolism_Homo sapiens_hsa002300.94764520
37Pyrimidine metabolism_Homo sapiens_hsa002400.94374555
38NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92104156
39Acute myeloid leukemia_Homo sapiens_hsa052210.91733400
40TNF signaling pathway_Homo sapiens_hsa046680.90244610
41Hematopoietic cell lineage_Homo sapiens_hsa046400.87079691
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85585303
43Herpes simplex infection_Homo sapiens_hsa051680.80833598
44Spliceosome_Homo sapiens_hsa030400.80433975
45Non-homologous end-joining_Homo sapiens_hsa034500.79185562
46mRNA surveillance pathway_Homo sapiens_hsa030150.75246819
47Epstein-Barr virus infection_Homo sapiens_hsa051690.74440836
48Prolactin signaling pathway_Homo sapiens_hsa049170.72714680
49Homologous recombination_Homo sapiens_hsa034400.72503829
50Circadian rhythm_Homo sapiens_hsa047100.72166465
51HTLV-I infection_Homo sapiens_hsa051660.71922782
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.71188632
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69315865
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68128896
55Nitrogen metabolism_Homo sapiens_hsa009100.67892247
56MAPK signaling pathway_Homo sapiens_hsa040100.65395112
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63519876
58Oxidative phosphorylation_Homo sapiens_hsa001900.59919869
59Fat digestion and absorption_Homo sapiens_hsa049750.58896869
60Ether lipid metabolism_Homo sapiens_hsa005650.58675305
61HIF-1 signaling pathway_Homo sapiens_hsa040660.58379544
62Fatty acid elongation_Homo sapiens_hsa000620.57330959
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56424537
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55432478
65B cell receptor signaling pathway_Homo sapiens_hsa046620.51313462
66Glycerophospholipid metabolism_Homo sapiens_hsa005640.47697255
67Viral myocarditis_Homo sapiens_hsa054160.46145391
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.45741096
69Parkinsons disease_Homo sapiens_hsa050120.44590799
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44518599
71Fructose and mannose metabolism_Homo sapiens_hsa000510.43054009
72Pentose phosphate pathway_Homo sapiens_hsa000300.42540389
73Fatty acid metabolism_Homo sapiens_hsa012120.39264720
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39147128
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36035094
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35695338
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.31564746
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.30929808
79Arachidonic acid metabolism_Homo sapiens_hsa005900.28861091
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28361033
81ABC transporters_Homo sapiens_hsa020100.27603091
82Butanoate metabolism_Homo sapiens_hsa006500.27171281
83Nucleotide excision repair_Homo sapiens_hsa034200.26142656
84Ras signaling pathway_Homo sapiens_hsa040140.23152513
85Olfactory transduction_Homo sapiens_hsa047400.23130498
86Toxoplasmosis_Homo sapiens_hsa051450.20870692
87Osteoclast differentiation_Homo sapiens_hsa043800.19750820
88Dorso-ventral axis formation_Homo sapiens_hsa043200.19381052
89Renin-angiotensin system_Homo sapiens_hsa046140.18938724
90Hepatitis B_Homo sapiens_hsa051610.17904201
91RNA degradation_Homo sapiens_hsa030180.17892517
92Alzheimers disease_Homo sapiens_hsa050100.15983477
93Viral carcinogenesis_Homo sapiens_hsa052030.15965081
94Biosynthesis of amino acids_Homo sapiens_hsa012300.15613160
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.15456068
96Glycerolipid metabolism_Homo sapiens_hsa005610.14658426
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.12984888
98Morphine addiction_Homo sapiens_hsa050320.12096644
99Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.12029503
100Platelet activation_Homo sapiens_hsa046110.10848955

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