XDH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oligosaccharide biosynthetic process (GO:0009312)9.65431525
2response to phenylpropanoid (GO:0080184)6.32429205
3ceramide catabolic process (GO:0046514)4.91536488
4exogenous drug catabolic process (GO:0042738)4.77897746
5cellular glucuronidation (GO:0052695)4.73435577
6uronic acid metabolic process (GO:0006063)4.71515407
7glucuronate metabolic process (GO:0019585)4.71515407
8negative regulation of execution phase of apoptosis (GO:1900118)4.71437276
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.71295724
10low-density lipoprotein particle clearance (GO:0034383)4.69064209
11cholesterol catabolic process (GO:0006707)4.68734325
12sterol catabolic process (GO:0016127)4.68734325
13alpha-linolenic acid metabolic process (GO:0036109)4.64564667
14* lactation (GO:0007595)4.55288797
15regulation of triglyceride catabolic process (GO:0010896)4.48424443
16complement activation, alternative pathway (GO:0006957)4.46973772
17ectoderm development (GO:0007398)4.16354078
18mammary gland epithelial cell differentiation (GO:0060644)4.09694707
19plasma lipoprotein particle clearance (GO:0034381)4.06863141
20drug metabolic process (GO:0017144)4.02421714
21phospholipid homeostasis (GO:0055091)3.96341775
22urea metabolic process (GO:0019627)3.94239324
23urea cycle (GO:0000050)3.94239324
24regulation of sequestering of triglyceride (GO:0010889)3.93349201
25negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.93011508
26intestinal cholesterol absorption (GO:0030299)3.90649008
27fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.85880189
28phospholipid efflux (GO:0033700)3.85691720
29fat-soluble vitamin biosynthetic process (GO:0042362)3.80483726
30regulation of protein activation cascade (GO:2000257)3.78670554
31omega-hydroxylase P450 pathway (GO:0097267)3.78413764
32ethanol metabolic process (GO:0006067)3.77617464
33regulation of cholesterol storage (GO:0010885)3.77399142
34* secretion by tissue (GO:0032941)3.76047371
35regulation of complement activation (GO:0030449)3.72238463
36complement activation, classical pathway (GO:0006958)3.71913603
37regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.71379537
38GDP-mannose metabolic process (GO:0019673)3.70943542
39fatty acid transmembrane transport (GO:1902001)3.67848724
40positive regulation of lipid catabolic process (GO:0050996)3.63699312
41arginine metabolic process (GO:0006525)3.63345722
42protein carboxylation (GO:0018214)3.62793333
43peptidyl-glutamic acid carboxylation (GO:0017187)3.62793333
44L-phenylalanine catabolic process (GO:0006559)3.62431083
45erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.62431083
46positive regulation of triglyceride lipase activity (GO:0061365)3.62257275
47positive regulation of lipoprotein lipase activity (GO:0051006)3.62257275
48glutathione biosynthetic process (GO:0006750)3.59059972
49nitrogen cycle metabolic process (GO:0071941)3.56503415
50erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.48796746
51L-phenylalanine metabolic process (GO:0006558)3.48796746
52sphingolipid catabolic process (GO:0030149)3.48184881
53cholesterol efflux (GO:0033344)3.47664940
54regulation of apoptotic process involved in morphogenesis (GO:1902337)3.47464601
55high-density lipoprotein particle remodeling (GO:0034375)3.47281348
56nucleotide-sugar biosynthetic process (GO:0009226)3.45878444
57oligosaccharide metabolic process (GO:0009311)3.45624779
58nonribosomal peptide biosynthetic process (GO:0019184)3.44764275
59epoxygenase P450 pathway (GO:0019373)3.44238573
60plasma lipoprotein particle assembly (GO:0034377)3.43318319
61steroid catabolic process (GO:0006706)3.42885434
62reverse cholesterol transport (GO:0043691)3.41057311
63regulation of cholesterol esterification (GO:0010872)3.39229734
64intestinal absorption (GO:0050892)3.39105238
65digestive system process (GO:0022600)3.37165680
66positive regulation of triglyceride metabolic process (GO:0090208)3.36105047
67positive regulation of fatty acid beta-oxidation (GO:0032000)3.34967263
68* body fluid secretion (GO:0007589)3.34640725
69regulation of phospholipid biosynthetic process (GO:0071071)3.34234813
70triglyceride biosynthetic process (GO:0019432)3.31626309
71triglyceride homeostasis (GO:0070328)3.30946828
72acylglycerol homeostasis (GO:0055090)3.30946828
73sulfur amino acid catabolic process (GO:0000098)3.29188110
74lipoprotein metabolic process (GO:0042157)3.28738032
75protein-lipid complex assembly (GO:0065005)3.28691222
76negative regulation of complement activation (GO:0045916)3.26983559
77maintenance of gastrointestinal epithelium (GO:0030277)3.26955949
78negative regulation of protein activation cascade (GO:2000258)3.26029746
79acyl-CoA biosynthetic process (GO:0071616)3.24778765
80thioester biosynthetic process (GO:0035384)3.24778765
81acylglycerol biosynthetic process (GO:0046463)3.24736290
82neutral lipid biosynthetic process (GO:0046460)3.24736290
83plasma lipoprotein particle remodeling (GO:0034369)3.23364200
84protein-lipid complex remodeling (GO:0034368)3.23364200
85macromolecular complex remodeling (GO:0034367)3.23364200
86homocysteine metabolic process (GO:0050667)3.22933643
87citrulline biosynthetic process (GO:0019240)3.22714859
88aromatic amino acid family catabolic process (GO:0009074)3.21235960
89calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.20124907
90cholesterol homeostasis (GO:0042632)3.18070993
91carnitine shuttle (GO:0006853)3.17723497
92lipoprotein transport (GO:0042953)3.17716155
93membrane lipid catabolic process (GO:0046466)3.16358690
94lipid storage (GO:0019915)3.16173390
95regulation of triglyceride metabolic process (GO:0090207)3.15056233
96negative regulation of fibrinolysis (GO:0051918)3.14851832
97sterol homeostasis (GO:0055092)3.14760916
98regulation of cholesterol homeostasis (GO:2000188)3.14178556
99flavonoid metabolic process (GO:0009812)3.10223436
100hormone catabolic process (GO:0042447)3.10167135
101drug transmembrane transport (GO:0006855)3.08028753
102tricarboxylic acid metabolic process (GO:0072350)3.07590649
103heme transport (GO:0015886)3.07091677
104bile acid biosynthetic process (GO:0006699)3.06667159
105alkaloid metabolic process (GO:0009820)3.06158946
106cysteine metabolic process (GO:0006534)3.05071874
107valine metabolic process (GO:0006573)3.04901606
108positive regulation of lipid storage (GO:0010884)3.04235844
109NADH metabolic process (GO:0006734)3.03419167
110urate metabolic process (GO:0046415)3.02413484
111apoptotic cell clearance (GO:0043277)3.02063903
112negative regulation of cholesterol transport (GO:0032375)3.02045584
113negative regulation of sterol transport (GO:0032372)3.02045584
114mitochondrial calcium ion transport (GO:0006851)3.00431783
115fatty acid beta-oxidation (GO:0006635)3.00068776
116acetyl-CoA metabolic process (GO:0006084)2.99611389
117lysine metabolic process (GO:0006553)2.99588234
118lysine catabolic process (GO:0006554)2.99588234
119regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.98851949
120kynurenine metabolic process (GO:0070189)2.94851119
121positive regulation of fatty acid oxidation (GO:0046321)2.94614044
122positive regulation of osteoblast proliferation (GO:0033690)2.94130684
123regulation of bile acid biosynthetic process (GO:0070857)2.93469680
124regulation of apoptotic cell clearance (GO:2000425)2.93373601
125drug catabolic process (GO:0042737)2.93178644
126fatty-acyl-CoA biosynthetic process (GO:0046949)2.92775095
127ethanol oxidation (GO:0006069)2.91128613
128protein activation cascade (GO:0072376)2.90236239
129amino-acid betaine metabolic process (GO:0006577)2.89657714
130very-low-density lipoprotein particle assembly (GO:0034379)2.89604843
131short-chain fatty acid metabolic process (GO:0046459)2.88814206
132regulation of guanylate cyclase activity (GO:0031282)2.88034353
133regulation of fatty acid beta-oxidation (GO:0031998)2.87534596
134peptide catabolic process (GO:0043171)2.87381696
135phenylpropanoid metabolic process (GO:0009698)2.87125183
136tryptophan catabolic process (GO:0006569)2.86362011
137indole-containing compound catabolic process (GO:0042436)2.86362011
138indolalkylamine catabolic process (GO:0046218)2.86362011
139fatty acid oxidation (GO:0019395)2.86212266
140opsonization (GO:0008228)2.86082766
141CDP-diacylglycerol biosynthetic process (GO:0016024)2.85882309
142plasma lipoprotein particle organization (GO:0071827)2.85002143
143sterol transport (GO:0015918)2.83476507
144cholesterol transport (GO:0030301)2.83476507
145regulation of fibrinolysis (GO:0051917)2.83178210
146bile acid metabolic process (GO:0008206)2.82978767
147antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.82931129
148antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.82931129
149fatty acid catabolic process (GO:0009062)2.81430757
150lipid oxidation (GO:0034440)2.81065860
151glyoxylate metabolic process (GO:0046487)2.80355504
152protein-lipid complex subunit organization (GO:0071825)2.80271325
153lipid homeostasis (GO:0055088)2.79728616
154complement activation (GO:0006956)2.78960196
155biotin metabolic process (GO:0006768)2.75755751
156tryptophan metabolic process (GO:0006568)2.74717497
157regulation of sterol transport (GO:0032371)2.74514091
158regulation of cholesterol transport (GO:0032374)2.74514091
159negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.73585234
160angiotensin maturation (GO:0002003)2.72398090
161positive regulation of fatty acid metabolic process (GO:0045923)2.72058981
162xenobiotic catabolic process (GO:0042178)2.71968369
163bile acid and bile salt transport (GO:0015721)2.70614096

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.42649816
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.46433934
3* RXR_22158963_ChIP-Seq_LIVER_Mouse4.86774265
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.37923323
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.20236708
6* EGR1_23403033_ChIP-Seq_LIVER_Mouse3.34339416
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.27338888
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.13235638
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.82023966
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.69553436
11* CLOCK_20551151_ChIP-Seq_293T_Human2.42671389
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.41622968
13* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.39092235
14* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.38543423
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.22714618
16* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.16589711
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.15019707
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.13161070
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.00712043
20* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92259813
21GATA1_22025678_ChIP-Seq_K562_Human1.91297065
22* IRF8_21731497_ChIP-ChIP_J774_Mouse1.91178933
23* IRF8_27001747_Chip-Seq_BMDM_Mouse1.81103824
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.80749407
25ESR1_21235772_ChIP-Seq_MCF-7_Human1.80213147
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.78685767
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77303394
28* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75448264
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.74112874
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.73910704
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.70263958
32CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.68324967
33RXR_22108803_ChIP-Seq_LS180_Human1.64995349
34GATA2_21666600_ChIP-Seq_HMVEC_Human1.56210678
35* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.53761075
36* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.53743733
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52362903
38PPAR_26484153_Chip-Seq_NCI-H1993_Human1.51983790
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.48753750
40ESR1_15608294_ChIP-ChIP_MCF-7_Human1.47330139
41SOX2_27498859_Chip-Seq_STOMACH_Mouse1.42036597
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.41680930
43CDX2_20551321_ChIP-Seq_CACO-2_Human1.39269538
44HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.38215832
45FOXA2_19822575_ChIP-Seq_HepG2_Human1.38165812
46AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.38042156
47STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.36915595
48* FOXA1_25552417_ChIP-Seq_VCAP_Human1.34112547
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.33385877
50TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.29349050
51GATA4_25053715_ChIP-Seq_YYC3_Human1.29036260
52CDX2_22108803_ChIP-Seq_LS180_Human1.27107700
53BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.26428882
54* TP63_23658742_ChIP-Seq_EP156T_Human1.25760199
55PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25600181
56SOX2_20726797_ChIP-Seq_SW620_Human1.24801531
57TCF4_18268006_ChIP-ChIP_LS174T_Human1.20876611
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16682106
59* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.15295103
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13615527
61TP53_18474530_ChIP-ChIP_U2OS_Human1.11242241
62PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08487322
63ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07843566
64GATA2_19941826_ChIP-Seq_K562_Human1.06670399
65CEBPB_22108803_ChIP-Seq_LS180_Human1.03306770
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.03001482
67* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01385695
68RACK7_27058665_Chip-Seq_MCF-7_Human1.00794198
69LXR_22292898_ChIP-Seq_THP-1_Human1.00628225
70ESR1_20079471_ChIP-ChIP_T-47D_Human0.99863204
71VDR_24787735_ChIP-Seq_THP-1_Human0.99651805
72GATA1_19941826_ChIP-Seq_K562_Human0.99167092
73MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98689975
74POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98486312
75KLF5_25053715_ChIP-Seq_YYC3_Human0.98111981
76* TBX20_22080862_ChIP-Seq_HEART_Mouse0.97841843
77* TBX20_22328084_ChIP-Seq_HEART_Mouse0.97841843
78NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97809463
79* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.96702723
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96668228
81CBP_21632823_ChIP-Seq_H3396_Human0.96583677
82HNF4A_19822575_ChIP-Seq_HepG2_Human0.96478623
83PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96278453
84CJUN_26792858_Chip-Seq_BT549_Human0.96217310
85P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96034928
86SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95257177
87GATA6_25053715_ChIP-Seq_YYC3_Human0.94994488
88SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94672451
89FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.93811692
90HIF1A_21447827_ChIP-Seq_MCF-7_Human0.92857737
91* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91642567
92KAP1_22055183_ChIP-Seq_ESCs_Mouse0.90955023
93NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90298237
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90298237
95STAT1_20625510_ChIP-Seq_HELA_Human0.89747767
96* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.88879409
97STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.88574925
98SPI1_23127762_ChIP-Seq_K562_Human0.87853908
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86718188
100FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86681029
101FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86331219
102NFYA_21822215_ChIP-Seq_K562_Human0.84350514
103ZNF217_24962896_ChIP-Seq_MCF-7_Human0.83835117
104ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83299773
105GATA3_24758297_ChIP-Seq_MCF-7_Human0.83194801
106RUNX_20019798_ChIP-Seq_JUKART_Human0.82951327
107KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.82864690
108PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.82598471
109CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.81673777
110GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.81344632
111E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.81000303
112SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.80844277
113* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.80649128
114* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80545918
115JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.79948163
116SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.79057452
117GATA1_19941827_ChIP-Seq_MEL_Mouse0.78818664
118* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.78750132
119* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.78750132
120JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78581871
121KDM2B_26808549_Chip-Seq_SUP-B15_Human0.77423239
122PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77390805
123RUNX1_27457419_Chip-Seq_LIVER_Mouse0.77379472
124* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.77197316
125GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.77186308
126PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.77134756
127AR_20517297_ChIP-Seq_VCAP_Human0.77082946
128TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76995170
129RUNX1_27514584_Chip-Seq_MCF-7_Human0.76363488
130SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76183277
131ERG_20517297_ChIP-Seq_VCAP_Human0.76001840
132CTNNB1_20460455_ChIP-Seq_HCT116_Human0.75981376
133ATF3_27146783_Chip-Seq_COLON_Human0.75393875
134BCAT_22108803_ChIP-Seq_LS180_Human0.75276313
135AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.73669688
136PIAS1_25552417_ChIP-Seq_VCAP_Human0.73663585
137STAT3_18555785_Chip-Seq_ESCs_Mouse0.71902783
138TAF2_19829295_ChIP-Seq_ESCs_Human0.71560412
139TP63_22573176_ChIP-Seq_HFKS_Human0.70959850
140PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.70916393
141GATA6_21074721_ChIP-Seq_CACO-2_Human0.70609366

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.60753471
2MP0002139_abnormal_hepatobiliary_system4.67166047
3MP0005085_abnormal_gallbladder_physiolo3.58740057
4MP0003718_maternal_effect3.43477192
5MP0005365_abnormal_bile_salt3.41013802
6MP0009840_abnormal_foam_cell3.19346541
7MP0008875_abnormal_xenobiotic_pharmacok3.13687718
8MP0010329_abnormal_lipoprotein_level3.00244723
9* MP0000627_abnormal_mammary_gland2.87445501
10MP0003191_abnormal_cellular_cholesterol2.77025600
11MP0003705_abnormal_hypodermis_morpholog2.72380922
12MP0004147_increased_porphyrin_level2.58678261
13MP0003252_abnormal_bile_duct2.54191681
14MP0001666_abnormal_nutrient_absorption2.50684592
15MP0008438_abnormal_cutaneous_collagen2.32211250
16MP0005670_abnormal_white_adipose2.16154073
17MP0002254_reproductive_system_inflammat2.14608191
18MP0005083_abnormal_biliary_tract2.08507503
19MP0004043_abnormal_pH_regulation2.05831666
20MP0004130_abnormal_muscle_cell1.94994143
21MP0002118_abnormal_lipid_homeostasis1.81421517
22MP0000609_abnormal_liver_physiology1.80710506
23MP0003300_gastrointestinal_ulcer1.80441411
24MP0005058_abnormal_lysosome_morphology1.76095499
25* MP0001881_abnormal_mammary_gland1.74449130
26MP0003724_increased_susceptibility_to1.71266949
27MP0003806_abnormal_nucleotide_metabolis1.68422804
28MP0003436_decreased_susceptibility_to1.67855441
29MP0004019_abnormal_vitamin_homeostasis1.65908114
30MP0005636_abnormal_mineral_homeostasis1.61530986
31MP0005332_abnormal_amino_acid1.58168557
32MP0005666_abnormal_adipose_tissue1.54952425
33MP0005275_abnormal_skin_tensile1.54146878
34MP0005395_other_phenotype1.47738907
35MP0003868_abnormal_feces_composition1.45987508
36MP0003303_peritoneal_inflammation1.44273950
37MP0010234_abnormal_vibrissa_follicle1.41707931
38MP0005319_abnormal_enzyme/_coenzyme1.41602142
39MP0002138_abnormal_hepatobiliary_system1.38065153
40MP0002876_abnormal_thyroid_physiology1.36727111
41MP0000678_abnormal_parathyroid_gland1.36233619
42MP0004185_abnormal_adipocyte_glucose1.34155325
43MP0003566_abnormal_cell_adhesion1.26372020
44MP0004947_skin_inflammation1.24088105
45MP0001958_emphysema1.23286385
46MP0000604_amyloidosis1.22779492
47MP0002098_abnormal_vibrissa_morphology1.20932721
48MP0002971_abnormal_brown_adipose1.20339734
49MP0001664_abnormal_digestion1.18948834
50MP0002419_abnormal_innate_immunity1.16892418
51MP0001533_abnormal_skeleton_physiology1.16434586
52MP0005167_abnormal_blood-brain_barrier1.15466143
53MP0009764_decreased_sensitivity_to1.15403610
54MP0005584_abnormal_enzyme/coenzyme_acti1.14445623
55MP0009643_abnormal_urine_homeostasis1.12069211
56MP0009785_altered_susceptibility_to1.10698804
57MP0005023_abnormal_wound_healing1.09939157
58MP0010352_gastrointestinal_tract_polyps1.09883932
59MP0008469_abnormal_protein_level1.09789607
60MP0005464_abnormal_platelet_physiology1.09515580
61MP0003959_abnormal_lean_body1.09504198
62MP0004782_abnormal_surfactant_physiolog1.09450939
63MP0010368_abnormal_lymphatic_system1.09302874
64MP0001765_abnormal_ion_homeostasis1.08798761
65MP0002796_impaired_skin_barrier1.07448881
66MP0002060_abnormal_skin_morphology1.06187908
67MP0000343_altered_response_to1.05440399
68MP0001835_abnormal_antigen_presentation1.03002755
69MP0009763_increased_sensitivity_to1.02516127
70MP0005375_adipose_tissue_phenotype1.01887298
71MP0002837_dystrophic_cardiac_calcinosis1.00674269
72MP0005025_abnormal_response_to1.00358721
73MP0009115_abnormal_fat_cell0.98846184
74MP0000569_abnormal_digit_pigmentation0.98298648
75MP0005334_abnormal_fat_pad0.97991409
76MP0003075_altered_response_to0.96834073
77MP0002166_altered_tumor_susceptibility0.96699563
78MP0003690_abnormal_glial_cell0.95538019
79MP0009379_abnormal_foot_pigmentation0.93368991
80MP0003195_calcinosis0.92756813
81MP0003656_abnormal_erythrocyte_physiolo0.92363048
82MP0005645_abnormal_hypothalamus_physiol0.91815626
83MP0000598_abnormal_liver_morphology0.91540671
84MP0001764_abnormal_homeostasis0.91163678
85MP0009278_abnormal_bone_marrow0.90904640
86MP0000685_abnormal_immune_system0.87911587
87MP0003453_abnormal_keratinocyte_physiol0.87420249
88MP0000490_abnormal_crypts_of0.87335920
89MP0005410_abnormal_fertilization0.87123338
90MP0006082_CNS_inflammation0.85713810
91MP0003183_abnormal_peptide_metabolism0.84607122
92MP0005535_abnormal_body_temperature0.84471689
93MP0000249_abnormal_blood_vessel0.84229732
94MP0001845_abnormal_inflammatory_respons0.83117107
95MP0005387_immune_system_phenotype0.82626537
96MP0001790_abnormal_immune_system0.82626537
97MP0001873_stomach_inflammation0.81352444
98MP0003866_abnormal_defecation0.81155815
99MP0005164_abnormal_response_to0.79261659
100MP0005166_decreased_susceptibility_to0.79147322
101MP0005448_abnormal_energy_balance0.78367549
102MP0004858_abnormal_nervous_system0.78158792
103MP0010155_abnormal_intestine_physiology0.77787669
104MP0005409_darkened_coat_color0.76385683
105MP0008004_abnormal_stomach_pH0.76176162
106MP0002896_abnormal_bone_mineralization0.76108467
107MP0003448_altered_tumor_morphology0.75811146
108MP0001879_abnormal_lymphatic_vessel0.75537242
109MP0000538_abnormal_urinary_bladder0.74815735
110MP0003879_abnormal_hair_cell0.74257841
111MP0001849_ear_inflammation0.72938093
112MP0002136_abnormal_kidney_physiology0.70676155
113MP0001853_heart_inflammation0.70561748
114MP0003186_abnormal_redox_activity0.70327434
115MP0004264_abnormal_extraembryonic_tissu0.70140861
116MP0000477_abnormal_intestine_morphology0.70008015
117* MP0009642_abnormal_blood_homeostasis0.69377912
118MP0000377_abnormal_hair_follicle0.68801961
119MP0001216_abnormal_epidermal_layer0.68210015
120MP0004510_myositis0.67778416
121MP0010678_abnormal_skin_adnexa0.67742492
122MP0001501_abnormal_sleep_pattern0.67653431
123MP0002998_abnormal_bone_remodeling0.67557481
124MP0003172_abnormal_lysosome_physiology0.67504662
125MP0003828_pulmonary_edema0.66516285
126MP0001756_abnormal_urination0.65144723
127MP0002168_other_aberrant_phenotype0.64944957
128MP0003045_fibrosis0.64097874
129MP0003011_delayed_dark_adaptation0.63671142
130MP0002078_abnormal_glucose_homeostasis0.62419225
131MP0003279_aneurysm0.62218349
132MP0004272_abnormal_basement_membrane0.61439835
133MP0003638_abnormal_response/metabolism_0.59980096
134MP0005501_abnormal_skin_physiology0.59286677
135MP0009765_abnormal_xenobiotic_induced0.59230706
136MP0003953_abnormal_hormone_level0.55753233
137MP0009697_abnormal_copulation0.54776464
138MP0002148_abnormal_hypersensitivity_rea0.53946257
139MP0001663_abnormal_digestive_system0.52594968
140MP0005451_abnormal_body_composition0.50780934
141MP0000230_abnormal_systemic_arterial0.47372586
142MP0000537_abnormal_urethra_morphology0.44860870
143MP0003329_amyloid_beta_deposits0.43671589
144* MP0003936_abnormal_reproductive_system0.43266432
145MP0005381_digestive/alimentary_phenotyp0.41786243
146MP0008260_abnormal_autophagy0.40314195

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)5.31634871
2Decreased circulating renin level (HP:0003351)5.12944110
3Deep venous thrombosis (HP:0002625)4.82316140
4Complement deficiency (HP:0004431)4.80782364
5Xanthomatosis (HP:0000991)4.66546552
6Systemic lupus erythematosus (HP:0002725)4.30639785
7Intrahepatic cholestasis (HP:0001406)3.98069357
8Hypobetalipoproteinemia (HP:0003563)3.94135206
9Abnormality of monocarboxylic acid metabolism (HP:0010996)3.78653755
10Abnormality of complement system (HP:0005339)3.75805176
11Abnormality of glutamine family amino acid metabolism (HP:0010902)3.70205993
12Epidermoid cyst (HP:0200040)3.55012016
13Hyperlipoproteinemia (HP:0010980)3.48908919
14Myocardial infarction (HP:0001658)3.45657415
15Hypolipoproteinemia (HP:0010981)3.44885692
16Hypercholesterolemia (HP:0003124)3.37137978
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.33604029
18Recurrent gram-negative bacterial infections (HP:0005420)3.30232520
19Hypoalphalipoproteinemia (HP:0003233)3.28832203
20Thin bony cortex (HP:0002753)3.25885009
21Gout (HP:0001997)3.25638910
22Alkalosis (HP:0001948)3.23622055
23Abnormality of the common coagulation pathway (HP:0010990)3.20717840
24Widely patent fontanelles and sutures (HP:0004492)3.19866274
25Abnormality of renin-angiotensin system (HP:0000847)3.19406244
26Abnormality of aromatic amino acid family metabolism (HP:0004338)3.18107331
27Prolonged partial thromboplastin time (HP:0003645)3.18041337
28Joint hemorrhage (HP:0005261)3.12661080
29Hyperglycinuria (HP:0003108)3.06570792
30Autoimmune thrombocytopenia (HP:0001973)3.05198218
31Right ventricular cardiomyopathy (HP:0011663)3.02833076
32Hydroxyprolinuria (HP:0003080)2.91707389
33Abnormality of proline metabolism (HP:0010907)2.91707389
34Hyperammonemia (HP:0001987)2.90119433
35Amyloidosis (HP:0011034)2.87810972
36Chronic diarrhea (HP:0002028)2.85870857
37Rickets (HP:0002748)2.83876173
38Glomerulonephritis (HP:0000099)2.80758613
39Hyperaldosteronism (HP:0000859)2.79689847
40Skin nodule (HP:0200036)2.78958849
41Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.76888243
42Abnormality of vitamin metabolism (HP:0100508)2.76469057
43Esophageal varix (HP:0002040)2.76027480
44Renal salt wasting (HP:0000127)2.74676576
45Fat malabsorption (HP:0002630)2.72505083
46Abnormality of the costochondral junction (HP:0000919)2.71253732
47Ketosis (HP:0001946)2.67984054
48Hypotension (HP:0002615)2.66205037
49Axonal loss (HP:0003447)2.65721911
50Abnormality of the vitamin B12 metabolism (HP:0004341)2.60935436
51Eczematoid dermatitis (HP:0000976)2.58755782
52Hypophosphatemia (HP:0002148)2.58566937
53Abnormality of glycine metabolism (HP:0010895)2.58517972
54Abnormality of serine family amino acid metabolism (HP:0010894)2.58517972
55Steatorrhea (HP:0002570)2.57121895
56Hypoglycemic coma (HP:0001325)2.56183083
57Polycythemia (HP:0001901)2.53946981
58Increased purine levels (HP:0004368)2.52740326
59Hyperuricemia (HP:0002149)2.52740326
60Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.51747213
61Conjugated hyperbilirubinemia (HP:0002908)2.51720794
62Congenital sensorineural hearing impairment (HP:0008527)2.51124081
63Abnormality of sulfur amino acid metabolism (HP:0004339)2.50616923
64Abnormality of fatty-acid metabolism (HP:0004359)2.48926553
65Abnormality of vitamin B metabolism (HP:0004340)2.47685603
66Protuberant abdomen (HP:0001538)2.46490427
67Flat acetabular roof (HP:0003180)2.46178032
68Hyperkalemia (HP:0002153)2.45767098
69Symptomatic seizures (HP:0011145)2.44538830
70Abnormality of pyrimidine metabolism (HP:0004353)2.43963297
71Glomerulosclerosis (HP:0000096)2.42539749
72Enlarged epiphyses (HP:0010580)2.42024041
73Abdominal distention (HP:0003270)2.39702353
74Abnormality of urine glucose concentration (HP:0011016)2.39421109
75Glycosuria (HP:0003076)2.39421109
76Metaphyseal irregularity (HP:0003025)2.36818014
77Hemorrhage of the eye (HP:0011885)2.36796167
78Abnormality of the intrinsic pathway (HP:0010989)2.35870063
79Abnormal tarsal ossification (HP:0008369)2.35663103
80Hypertriglyceridemia (HP:0002155)2.34231864
81Hematochezia (HP:0002573)2.32054625
82Abnormality of chloride homeostasis (HP:0011422)2.28907559
83Vacuolated lymphocytes (HP:0001922)2.27400852
84Increased mean platelet volume (HP:0011877)2.25335868
85Posterior subcapsular cataract (HP:0007787)2.23899959
86Gingival bleeding (HP:0000225)2.22498085
87Acanthocytosis (HP:0001927)2.22014589
88Elevated alkaline phosphatase (HP:0003155)2.21102343
89Peritonitis (HP:0002586)2.20992571
90Dehydration (HP:0001944)2.18509957
91* Abnormality of purine metabolism (HP:0004352)2.17592538
92Abnormality of aspartate family amino acid metabolism (HP:0010899)2.17256975
93Recurrent bacterial skin infections (HP:0005406)2.16183259
94Abnormal enzyme/coenzyme activity (HP:0012379)2.15879480
95Tubulointerstitial nephritis (HP:0001970)2.15855419
96Increased connective tissue (HP:0009025)2.15328248
97Ketoacidosis (HP:0001993)2.14909541
98Pigmentary retinal degeneration (HP:0001146)2.13383168
99Abnormality of alkaline phosphatase activity (HP:0004379)2.12784372
100Ileus (HP:0002595)2.11889423
101Spontaneous hematomas (HP:0007420)2.11092217
102* Nephritis (HP:0000123)2.10680802
103Hypokalemia (HP:0002900)2.09784204
104Abnormality of iron homeostasis (HP:0011031)2.09431275
105Abnormality of transition element cation homeostasis (HP:0011030)2.09023025
106Abnormality of calcium-phosphate metabolism (HP:0100530)2.08814591
107Abnormal platelet volume (HP:0011876)2.07887380
108Alopecia of scalp (HP:0002293)2.06354050
109Delayed epiphyseal ossification (HP:0002663)2.06289257
110Hypophosphatemic rickets (HP:0004912)2.06200355
111Proximal tubulopathy (HP:0000114)2.06088293
112Mitral stenosis (HP:0001718)2.04816452
113Osteolytic defects of the phalanges of the hand (HP:0009771)2.04065481
114Osteolytic defects of the hand bones (HP:0009699)2.04065481
115Abnormal hair laboratory examination (HP:0003328)2.03628988
116Hyperglycinemia (HP:0002154)2.03488759
117Cerebral aneurysm (HP:0004944)2.03446620
118Pustule (HP:0200039)2.03048237
119* Nephrolithiasis (HP:0000787)2.03030709
120Generalized aminoaciduria (HP:0002909)2.02466825
121Vascular calcification (HP:0004934)2.02256834
122Cardiovascular calcification (HP:0011915)2.02235199
123Focal segmental glomerulosclerosis (HP:0000097)2.01946322
124Recurrent abscess formation (HP:0002722)2.00823418
125* Abnormality of nucleobase metabolism (HP:0010932)2.00015115
126Broad metatarsal (HP:0001783)1.97812330
127Irritability (HP:0000737)1.97687584
128Mucopolysacchariduria (HP:0008155)1.97583735
129Urinary glycosaminoglycan excretion (HP:0003541)1.97583735
130Interstitial pulmonary disease (HP:0006530)1.97162239
131Gingivitis (HP:0000230)1.96358505
132Malnutrition (HP:0004395)1.95172880
133Thick nail (HP:0001805)1.93930157
134Villous atrophy (HP:0011473)1.93726747
135Abnormality of small intestinal villus morphology (HP:0011472)1.93726747
136Asymmetric septal hypertrophy (HP:0001670)1.93103769
137Hyponatremia (HP:0002902)1.92745025
138Increased serum ferritin (HP:0003281)1.92601091
139Cerebral palsy (HP:0100021)1.91678750
140Abnormality of polysaccharide metabolism (HP:0011012)1.90989646
141Abnormality of glycosaminoglycan metabolism (HP:0004371)1.90989646
142Abnormality of mucopolysaccharide metabolism (HP:0011020)1.90989646
143Loss of speech (HP:0002371)1.90594534
144Wide cranial sutures (HP:0010537)1.89681890
145Abnormality of macrophages (HP:0004311)1.89672993
146Periodontitis (HP:0000704)1.88692300
147Menorrhagia (HP:0000132)1.87915611
148Pancreatitis (HP:0001733)1.86614155
149Tetraparesis (HP:0002273)1.82466309
150Nausea (HP:0002018)1.80687518
151Dysostosis multiplex (HP:0000943)1.79964982
152Hepatocellular carcinoma (HP:0001402)1.79820515
153Abnormal cartilage morphology (HP:0002763)1.78216466
154Hyperbilirubinemia (HP:0002904)1.77247425
155Metabolic acidosis (HP:0001942)1.76434585
156Aortic aneurysm (HP:0004942)1.76195033

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.10786275
2ACVR1B3.60865058
3EPHA23.48305916
4TRIB33.29139239
5SIK13.24798190
6CAMK1D3.12541157
7RIPK12.69646435
8FGFR42.43644699
9MST1R2.37767186
10PKN22.36087742
11TYK22.26059257
12TTN2.24362595
13BCKDK2.23077705
14EPHB12.18827934
15CAMK1G2.18243152
16TGFBR22.10108848
17MAP2K62.05594131
18PTK62.04727346
19FRK2.01673650
20TAOK31.84432013
21STK391.78094931
22TBK11.75783691
23JAK11.70439783
24OXSR11.67472262
25MAP3K121.49939366
26MST41.44767282
27TIE11.40858595
28IRAK31.39653663
29MAP2K31.37200677
30MAP3K31.32702089
31CSK1.31242411
32KIT1.26666415
33IKBKE1.25769535
34LMTK21.25125800
35MAP3K141.24618781
36CSNK1A11.24471093
37NEK91.23401717
38FGFR31.22927990
39IRAK11.21425171
40PRKAA21.19970792
41JAK31.19681088
42LATS11.19584215
43EPHA31.18762573
44TESK11.18398025
45JAK21.08116902
46ZAP701.07091084
47BMPR21.01625852
48STK38L1.00709932
49MAP3K71.00534554
50NLK1.00041557
51ICK0.99592328
52PDGFRA0.99555167
53INSRR0.99300745
54PIK3CA0.97713622
55KDR0.97259107
56LRRK20.96512393
57MAP4K10.96077804
58GRK60.95254484
59STK240.94464114
60BMX0.92968078
61MET0.92528497
62BLK0.91718776
63STK100.91018745
64ARAF0.88580920
65DAPK20.87209413
66PTK20.87042742
67TRPM70.86579086
68MAPK110.85613050
69MAP3K90.83594485
70PDGFRB0.83373276
71MAP3K100.83227775
72CDK60.78361170
73GRK70.76309342
74MYLK0.74444213
75GRK10.73056567
76PRKG20.72669002
77PINK10.72545497
78FER0.71736838
79TESK20.70330255
80FLT30.69526915
81EPHB20.69266228
82CAMK2D0.68261804
83IRAK40.67942396
84PRKACG0.67877271
85PDPK10.66390493
86CSF1R0.66367858
87STK380.64290681
88ERBB30.63201391
89NEK60.62565276
90MAP3K130.62232945
91HCK0.62064724
92FGFR20.62061797
93PDK40.61854375
94PDK30.61854375
95CASK0.59104681
96ERBB40.58881210
97DDR20.57513176
98BCR0.57007242
99GSK3A0.56637090
100PIK3CG0.55922886
101PDK20.54317773
102RET0.54013098
103STK30.53949303
104PRKCD0.53751840
105MAP3K20.53390673
106ITK0.52962815
107IKBKB0.52316628
108MAPK120.51713417
109SGK30.51547799
110CHUK0.51281319
111EGFR0.48913327
112MAPKAPK30.48712625
113CAMK2G0.48535683
114IGF1R0.48052013
115FGR0.47845297
116PRKD10.47331593
117MAP2K20.47234008
118PRKCZ0.46673229
119PRKAA10.46197630
120PRKCE0.45417168
121RIPK40.45380094
122EIF2AK30.44372745
123PAK40.44231235
124ABL20.43904699
125MTOR0.43782054
126SRC0.43655492
127PRKCA0.43262645
128ERBB20.42328026
129PDK10.40564482
130CAMK2B0.40323233
131MATK0.40239058
132MAP3K110.39301327
133MUSK0.39157661
134PRKCH0.38907412
135MAP3K10.38658851
136EEF2K0.38292580
137MOS0.38233638
138NME20.37669117
139BTK0.37445824
140ABL10.37370292
141TAOK10.36893077
142KSR20.32042149
143YES10.29481050

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001202.96998831
2Nitrogen metabolism_Homo sapiens_hsa009102.72160486
3Staphylococcus aureus infection_Homo sapiens_hsa051502.70722712
4PPAR signaling pathway_Homo sapiens_hsa033202.59273170
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.57382719
6Complement and coagulation cascades_Homo sapiens_hsa046102.53126181
7Fatty acid degradation_Homo sapiens_hsa000712.48362279
8Arginine biosynthesis_Homo sapiens_hsa002202.43339495
9Fat digestion and absorption_Homo sapiens_hsa049752.31543037
10Fatty acid biosynthesis_Homo sapiens_hsa000612.27063258
11Tryptophan metabolism_Homo sapiens_hsa003802.19033577
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.08150124
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.04775178
14Fatty acid metabolism_Homo sapiens_hsa012122.03044846
15Propanoate metabolism_Homo sapiens_hsa006401.96574466
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.90045324
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.84250266
18Linoleic acid metabolism_Homo sapiens_hsa005911.78415237
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.77509280
20Starch and sucrose metabolism_Homo sapiens_hsa005001.76671344
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.71446311
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.70339880
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.61649771
24Histidine metabolism_Homo sapiens_hsa003401.59368910
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.56576304
26* Peroxisome_Homo sapiens_hsa041461.49438192
27beta-Alanine metabolism_Homo sapiens_hsa004101.46815066
28Bile secretion_Homo sapiens_hsa049761.43809348
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42408003
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.40025653
31Galactose metabolism_Homo sapiens_hsa000521.39661888
32Chemical carcinogenesis_Homo sapiens_hsa052041.38808091
33ABC transporters_Homo sapiens_hsa020101.38583510
34Vitamin digestion and absorption_Homo sapiens_hsa049771.30525128
35Pyruvate metabolism_Homo sapiens_hsa006201.27951235
36Retinol metabolism_Homo sapiens_hsa008301.21212559
37Butanoate metabolism_Homo sapiens_hsa006501.20472328
38Glycerolipid metabolism_Homo sapiens_hsa005611.18194878
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.18009599
40Arachidonic acid metabolism_Homo sapiens_hsa005901.17243470
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14707331
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14143812
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.09145450
44Phenylalanine metabolism_Homo sapiens_hsa003601.07406479
45Carbon metabolism_Homo sapiens_hsa012001.06821935
46* Caffeine metabolism_Homo sapiens_hsa002321.02079825
47Renin-angiotensin system_Homo sapiens_hsa046141.01614278
48Adipocytokine signaling pathway_Homo sapiens_hsa049200.96754877
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94591303
50Folate biosynthesis_Homo sapiens_hsa007900.94272979
51Ether lipid metabolism_Homo sapiens_hsa005650.92720700
52Insulin resistance_Homo sapiens_hsa049310.90873614
53Selenocompound metabolism_Homo sapiens_hsa004500.89674324
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89170274
55Sulfur metabolism_Homo sapiens_hsa009200.88368401
56Lysine degradation_Homo sapiens_hsa003100.88234843
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86559464
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.86363127
59* Drug metabolism - other enzymes_Homo sapiens_hsa009830.79991570
60Tyrosine metabolism_Homo sapiens_hsa003500.78803386
61Mineral absorption_Homo sapiens_hsa049780.76706571
62Fatty acid elongation_Homo sapiens_hsa000620.75760254
63Pertussis_Homo sapiens_hsa051330.74855372
64Leishmaniasis_Homo sapiens_hsa051400.71665985
65Lysosome_Homo sapiens_hsa041420.68645658
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.67849016
67Pentose phosphate pathway_Homo sapiens_hsa000300.64606924
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64324780
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64273159
70Biosynthesis of amino acids_Homo sapiens_hsa012300.63498017
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63253783
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62884821
73Malaria_Homo sapiens_hsa051440.61096340
74Glutathione metabolism_Homo sapiens_hsa004800.58603652
75Amoebiasis_Homo sapiens_hsa051460.57402313
76Osteoclast differentiation_Homo sapiens_hsa043800.57151983
77Arginine and proline metabolism_Homo sapiens_hsa003300.56711192
78Pancreatic secretion_Homo sapiens_hsa049720.55427703
79Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55308052
80Steroid biosynthesis_Homo sapiens_hsa001000.54973676
81Fructose and mannose metabolism_Homo sapiens_hsa000510.50001617
82Toxoplasmosis_Homo sapiens_hsa051450.49988623
83Asthma_Homo sapiens_hsa053100.49554898
84* Metabolic pathways_Homo sapiens_hsa011000.49543023
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49249313
86Sulfur relay system_Homo sapiens_hsa041220.49064678
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48899560
88AMPK signaling pathway_Homo sapiens_hsa041520.47920208
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46379510
90Other glycan degradation_Homo sapiens_hsa005110.44965044
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43700730
92Hepatitis C_Homo sapiens_hsa051600.43594613
93Tuberculosis_Homo sapiens_hsa051520.41148830
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.40240139
95ECM-receptor interaction_Homo sapiens_hsa045120.36681481
96Protein digestion and absorption_Homo sapiens_hsa049740.35822616
97Legionellosis_Homo sapiens_hsa051340.33920657
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32935863
99Insulin signaling pathway_Homo sapiens_hsa049100.32468935
100TNF signaling pathway_Homo sapiens_hsa046680.32296616
101Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31686944
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.29511661
103NF-kappa B signaling pathway_Homo sapiens_hsa040640.27992818
104Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27294847
105Influenza A_Homo sapiens_hsa051640.26859447
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.26668122
107Cyanoamino acid metabolism_Homo sapiens_hsa004600.25576530
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.25444679
109Prolactin signaling pathway_Homo sapiens_hsa049170.25009102
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.24875374
111Type II diabetes mellitus_Homo sapiens_hsa049300.24482261
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.24113494
113Vitamin B6 metabolism_Homo sapiens_hsa007500.23853198
114Acute myeloid leukemia_Homo sapiens_hsa052210.23835328
115Sphingolipid metabolism_Homo sapiens_hsa006000.23796960
116Allograft rejection_Homo sapiens_hsa053300.23128981
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.21912448
118Autoimmune thyroid disease_Homo sapiens_hsa053200.19183443
119Graft-versus-host disease_Homo sapiens_hsa053320.18156627
120Thyroid hormone synthesis_Homo sapiens_hsa049180.09569611
121Type I diabetes mellitus_Homo sapiens_hsa049400.08359674
122Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.07512514
123Salivary secretion_Homo sapiens_hsa049700.04879806

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