XIRP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* sarcomere organization (GO:0045214)9.23670129
2muscle filament sliding (GO:0030049)9.02074380
3actin-myosin filament sliding (GO:0033275)9.02074380
4cardiac myofibril assembly (GO:0055003)8.49311310
5myofibril assembly (GO:0030239)8.06398523
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.88428108
7actin-mediated cell contraction (GO:0070252)7.48426018
8regulation of skeletal muscle contraction (GO:0014819)7.44044916
9plasma membrane repair (GO:0001778)7.03516558
10negative regulation of potassium ion transmembrane transport (GO:1901380)7.03127060
11positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)7.00797621
12cardiac muscle contraction (GO:0060048)6.75714127
13regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.57344259
14regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.32354458
15* cardiac muscle cell development (GO:0055013)6.00932587
16sarcoplasmic reticulum calcium ion transport (GO:0070296)5.99758636
17striated muscle contraction (GO:0006941)5.98072263
18* actomyosin structure organization (GO:0031032)5.94690629
19regulation of relaxation of muscle (GO:1901077)5.80413011
20regulation of actin filament-based movement (GO:1903115)5.77933977
21cardiac muscle tissue morphogenesis (GO:0055008)5.76009083
22adult heart development (GO:0007512)5.71810282
23actin filament-based movement (GO:0030048)5.65516582
24* cardiac cell development (GO:0055006)5.63471758
25ventricular cardiac muscle cell action potential (GO:0086005)5.60423151
26regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.56320271
27regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.55585415
28tricarboxylic acid cycle (GO:0006099)5.54218005
29cardiac muscle hypertrophy (GO:0003300)5.49503132
30carnitine shuttle (GO:0006853)5.30563895
31ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.28596220
32bundle of His cell to Purkinje myocyte communication (GO:0086069)5.28192914
33striated muscle hypertrophy (GO:0014897)5.26710380
34regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.25297567
35muscle tissue morphogenesis (GO:0060415)5.25284196
36regulation of striated muscle contraction (GO:0006942)5.03350125
37regulation of cell communication by electrical coupling (GO:0010649)5.02215965
38regulation of sarcomere organization (GO:0060297)5.00785033
39skeletal muscle contraction (GO:0003009)4.95068673
40response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.93807939
41regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.87801369
42heart process (GO:0003015)4.76270248
43heart contraction (GO:0060047)4.76270248
44heart trabecula formation (GO:0060347)4.69721967
45muscle hypertrophy (GO:0014896)4.65910210
46cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.57101883
47regulation of membrane repolarization (GO:0060306)4.55027518
48fatty acid transmembrane transport (GO:1902001)4.52598987
49regulation of the force of heart contraction (GO:0002026)4.44810262
50regulation of acyl-CoA biosynthetic process (GO:0050812)4.42557809
51cell communication involved in cardiac conduction (GO:0086065)4.41384891
52muscle contraction (GO:0006936)4.12885283
53negative regulation of protein localization to cell surface (GO:2000009)4.07465046
54response to inactivity (GO:0014854)4.05482163
55regulation of cofactor metabolic process (GO:0051193)4.03244469
56regulation of coenzyme metabolic process (GO:0051196)4.03244469
57cardiac muscle cell action potential (GO:0086001)4.01866036
58muscle adaptation (GO:0043500)3.98964943
59cardiac muscle cell action potential involved in contraction (GO:0086002)3.97016822
60cardiac chamber formation (GO:0003207)3.96035657
61negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.95560759
62positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.93622170
63creatine metabolic process (GO:0006600)3.92106643
64regulation of cardiac muscle contraction (GO:0055117)3.91632886
65cell communication by electrical coupling (GO:0010644)3.91372572
66carnitine transmembrane transport (GO:1902603)3.90262695
67skeletal muscle adaptation (GO:0043501)3.88543061
68membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.86138548
69negative regulation of striated muscle cell apoptotic process (GO:0010664)3.85289826
70regulation of heart rate (GO:0002027)3.84185763
71* striated muscle cell development (GO:0055002)3.84126788
72muscle system process (GO:0003012)3.82156804
73negative regulation of potassium ion transport (GO:0043267)3.81933261
74cardiac muscle adaptation (GO:0014887)3.77907550
75cardiac muscle hypertrophy in response to stress (GO:0014898)3.77907550
76muscle hypertrophy in response to stress (GO:0003299)3.77907550
77regulation of ATPase activity (GO:0043462)3.77048396
78regulation of ATP catabolic process (GO:1903289)3.77048396
79striated muscle adaptation (GO:0014888)3.75009064
80cardiac ventricle formation (GO:0003211)3.72139921
81regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.69348643
82regulation of cardioblast differentiation (GO:0051890)3.67476772
83regulation of cardiac muscle cell contraction (GO:0086004)3.65749558
84regulation of muscle system process (GO:0090257)3.61676181
85response to epinephrine (GO:0071871)3.59002067
86regulation of heart contraction (GO:0008016)3.54876631
87carnitine transport (GO:0015879)3.54847319
88amino-acid betaine transport (GO:0015838)3.54847319
89mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.52402143
90muscle fiber development (GO:0048747)3.50378889
91muscle cell cellular homeostasis (GO:0046716)3.49747263
92regulation of muscle contraction (GO:0006937)3.47190376
93response to caffeine (GO:0031000)3.46252782
94positive regulation of cation channel activity (GO:2001259)3.41960444
95regulation of calcium ion transmembrane transport (GO:1903169)3.41700252
96regulation of calcium ion transmembrane transporter activity (GO:1901019)3.41700252
972-oxoglutarate metabolic process (GO:0006103)3.41166817
98NADH metabolic process (GO:0006734)3.40285312
99striated muscle atrophy (GO:0014891)3.39307550
100skeletal muscle tissue development (GO:0007519)3.35580461
101response to muscle activity (GO:0014850)3.33201399
102muscle cell fate commitment (GO:0042693)3.30816887
103cardiac conduction (GO:0061337)3.30251403
104relaxation of cardiac muscle (GO:0055119)3.30113032
105skeletal muscle fiber development (GO:0048741)3.29400495
106* muscle cell development (GO:0055001)3.28843430
107cellular response to epinephrine stimulus (GO:0071872)3.28006134
108regulation of sulfur metabolic process (GO:0042762)3.27588729
109regulation of heart rate by cardiac conduction (GO:0086091)3.26644988
110energy coupled proton transport, down electrochemical gradient (GO:0015985)3.25313429
111ATP synthesis coupled proton transport (GO:0015986)3.25313429
112negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.25305647
113negative regulation of calcium ion transmembrane transport (GO:1903170)3.24806634
114negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.24806634
115regulation of sequestering of triglyceride (GO:0010889)3.22341958
116positive regulation of heart rate (GO:0010460)3.21135316
117myotube cell development (GO:0014904)3.19740328
118regulation of myoblast differentiation (GO:0045661)3.17972324
119muscle atrophy (GO:0014889)3.15116370
120relaxation of muscle (GO:0090075)3.14688846

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.91173662
2EP300_21415370_ChIP-Seq_HL-1_Mouse4.71493518
3TBX20_22328084_ChIP-Seq_HEART_Mouse4.07431665
4TBX20_22080862_ChIP-Seq_HEART_Mouse4.07431665
5ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.76168636
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.46088949
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.42015399
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.35972378
9ESR1_20079471_ChIP-ChIP_T-47D_Human3.31116609
10ZNF263_19887448_ChIP-Seq_K562_Human3.22307800
11* MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.11456420
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.79849917
13CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.57857483
14GATA4_21415370_ChIP-Seq_HL-1_Mouse2.28834728
15* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.13270250
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.11208882
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.08510653
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.07889548
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01608628
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.98124602
21GATA1_22025678_ChIP-Seq_K562_Human1.94638435
22EZH2_22144423_ChIP-Seq_EOC_Human1.93325048
23ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.81194019
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.79034692
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.76977087
26NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.75055702
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.66946493
28CLOCK_20551151_ChIP-Seq_293T_Human1.66068472
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63186646
30PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.62870614
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47886479
32CTCF_27219007_Chip-Seq_Bcells_Human1.41463833
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37858920
34* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.37008767
35* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.36399924
36BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.31991195
37PPARA_22158963_ChIP-Seq_LIVER_Mouse1.30283826
38DROSHA_22980978_ChIP-Seq_HELA_Human1.29928956
39RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.26947600
40FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.26609200
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25674849
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.25266476
43PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.24779546
44LXR_22158963_ChIP-Seq_LIVER_Mouse1.24481954
45* KDM2B_26808549_Chip-Seq_DND41_Human1.24046414
46PPAR_26484153_Chip-Seq_NCI-H1993_Human1.22862084
47TP63_22573176_ChIP-Seq_HFKS_Human1.22766979
48NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.21846398
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20683149
50ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20263283
51SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.19084882
52ESR1_21235772_ChIP-Seq_MCF-7_Human1.17757833
53LXR_22292898_ChIP-Seq_THP-1_Human1.17312157
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16078093
55TP63_17297297_ChIP-ChIP_HaCaT_Human1.15719752
56ISL1_27105846_Chip-Seq_CPCs_Mouse1.15298762
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.15218649
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.14914541
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.12379000
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.12206549
61EZH2_27294783_Chip-Seq_ESCs_Mouse1.11213508
62ATF3_27146783_Chip-Seq_COLON_Human1.10647846
63* RACK7_27058665_Chip-Seq_MCF-7_Human1.09238771
64SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09096859
65GATA1_19941826_ChIP-Seq_K562_Human1.08103462
66BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07020278
67SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06504279
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05135212
69RUNX1_27514584_Chip-Seq_MCF-7_Human1.04765574
70SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01183208
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00926481
72KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00676491
73RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97911041
74EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97911041
75SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97442839
76CJUN_26792858_Chip-Seq_BT549_Human0.97424843
77UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97075154
78SPI1_20517297_ChIP-Seq_HL60_Human0.96998482
79* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.96847398
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96018613
81MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95000636
82CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94452678
83FOXA2_19822575_ChIP-Seq_HepG2_Human0.91006264
84P68_20966046_ChIP-Seq_HELA_Human0.90712283
85* RXR_22158963_ChIP-Seq_LIVER_Mouse0.89969619
86EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89911439
87NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89524380
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89524380
89NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89102962
90P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87407139
91EZH2_27304074_Chip-Seq_ESCs_Mouse0.86903823
92ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.86862006
93FOXH1_21741376_ChIP-Seq_ESCs_Human0.85942605
94WT1_19549856_ChIP-ChIP_CCG9911_Human0.85685660
95PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.85632840
96SMAD3_21741376_ChIP-Seq_HESCs_Human0.85395734
97GF1_26923725_Chip-Seq_HPCs_Mouse0.84988962
98GATA2_19941826_ChIP-Seq_K562_Human0.84785034
99LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84105224
100ZNF274_21170338_ChIP-Seq_K562_Hela0.83825536
101PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.83365931
102AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83125836
103* OCT4_20526341_ChIP-Seq_ESCs_Human0.83086143
104SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.82710736
105* TP53_23651856_ChIP-Seq_MEFs_Mouse0.82521787
106GATA1_19941827_ChIP-Seq_MEL86_Mouse0.81341574
107KDM2B_26808549_Chip-Seq_K562_Human0.81221099
108SMC1_22415368_ChIP-Seq_MEFs_Mouse0.80087041
109GATA1_19941827_ChIP-Seq_MEL_Mouse0.80071287
110DNAJC2_21179169_ChIP-ChIP_NT2_Human0.80015508
111ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79680690
112* CTCF_21964334_Chip-Seq_Bcells_Human0.79548692
113SUZ12_27294783_Chip-Seq_NPCs_Mouse0.79300416
114WT1_25993318_ChIP-Seq_PODOCYTE_Human0.78820747
115SOX2_21211035_ChIP-Seq_LN229_Gbm0.78803684
116SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.78696716
117PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.77897782
118PCGF2_27294783_Chip-Seq_NPCs_Mouse0.77540308
119* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.77366461
120STAT3_1855785_ChIP-Seq_MESCs_Mouse0.77244734
121SMAD4_21741376_ChIP-Seq_HESCs_Human0.77147718
122STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.76766343
123DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.76283809
124YY1_22570637_ChIP-Seq_MALME-3M_Human0.76096601
125WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.74386950
126EZH2_27294783_Chip-Seq_NPCs_Mouse0.74357238
127SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.73796871
128JARID2_20075857_ChIP-Seq_MESCs_Mouse0.73673576
129MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.70996498
130LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.70682324
131GBX2_23144817_ChIP-Seq_PC3_Human0.69757768
132SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69583001
133MYC_27129775_Chip-Seq_CORNEA_Mouse0.69334085
134CRX_20693478_ChIP-Seq_RETINA_Mouse0.68527228
135TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.68406062

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.69426972
2MP0000751_myopathy5.58796655
3MP0003646_muscle_fatigue5.53573036
4MP0004084_abnormal_cardiac_muscle5.38346163
5MP0000749_muscle_degeneration4.62594167
6MP0004215_abnormal_myocardial_fiber4.44207643
7MP0004036_abnormal_muscle_relaxation4.31642152
8MP0005330_cardiomyopathy3.81521083
9* MP0004087_abnormal_muscle_fiber3.29642878
10MP0004145_abnormal_muscle_electrophysio3.27625486
11MP0000750_abnormal_muscle_regeneration3.07350842
12MP0002106_abnormal_muscle_physiology2.95414048
13* MP0002972_abnormal_cardiac_muscle2.94260327
14* MP0005620_abnormal_muscle_contractility2.82390418
15MP0008775_abnormal_heart_ventricle2.71371599
16MP0002269_muscular_atrophy2.61289428
17MP0000747_muscle_weakness2.56608967
18* MP0010630_abnormal_cardiac_muscle2.51519203
19* MP0003137_abnormal_impulse_conducting2.48176961
20MP0004130_abnormal_muscle_cell2.45276179
21MP0005369_muscle_phenotype2.40025116
22MP0000759_abnormal_skeletal_muscle2.36697142
23* MP0005385_cardiovascular_system_phenoty2.35883271
24* MP0001544_abnormal_cardiovascular_syste2.35883271
25MP0004484_altered_response_of2.27199105
26MP0006138_congestive_heart_failure2.19772770
27MP0004510_myositis2.07670704
28MP0003828_pulmonary_edema2.00704492
29MP0003221_abnormal_cardiomyocyte_apopto2.00047640
30MP0004085_abnormal_heartbeat1.90289726
31MP0004233_abnormal_muscle_weight1.87011996
32MP0003950_abnormal_plasma_membrane1.84477890
33MP0006036_abnormal_mitochondrial_physio1.56375161
34MP0002332_abnormal_exercise_endurance1.43024387
35MP0005666_abnormal_adipose_tissue1.37210313
36* MP0002127_abnormal_cardiovascular_syste1.29227659
37MP0003567_abnormal_fetal_cardiomyocyte1.26618323
38MP0005670_abnormal_white_adipose1.19448879
39MP0000733_abnormal_muscle_development1.13969614
40MP0002108_abnormal_muscle_morphology1.10659168
41MP0002234_abnormal_pharynx_morphology1.09214791
42* MP0000266_abnormal_heart_morphology1.09079493
43MP0000343_altered_response_to1.05355030
44MP0004185_abnormal_adipocyte_glucose1.05059494
45MP0003279_aneurysm1.04178480
46MP0010368_abnormal_lymphatic_system0.97327900
47MP0005375_adipose_tissue_phenotype0.96546942
48MP0003705_abnormal_hypodermis_morpholog0.95412889
49MP0001661_extended_life_span0.89603964
50MP0005165_increased_susceptibility_to0.88965005
51MP0006035_abnormal_mitochondrial_morpho0.86644294
52MP0003566_abnormal_cell_adhesion0.84180029
53MP0005451_abnormal_body_composition0.79668236
54MP0002128_abnormal_blood_circulation0.79105415
55MP0005623_abnormal_meninges_morphology0.77869763
56MP0005266_abnormal_metabolism0.77760110
57MP0005275_abnormal_skin_tensile0.74645196
58MP0000230_abnormal_systemic_arterial0.67535063
59MP0000013_abnormal_adipose_tissue0.67366154
60MP0002971_abnormal_brown_adipose0.67023130
61MP0008004_abnormal_stomach_pH0.63681423
62MP0005167_abnormal_blood-brain_barrier0.63162894
63MP0000767_abnormal_smooth_muscle0.62681613
64MP0003806_abnormal_nucleotide_metabolis0.60246064
65MP0004270_analgesia0.59909507
66MP0000003_abnormal_adipose_tissue0.57487170
67MP0004272_abnormal_basement_membrane0.56145549
68MP0008438_abnormal_cutaneous_collagen0.55985722
69MP0001879_abnormal_lymphatic_vessel0.51496884
70MP0002909_abnormal_adrenal_gland0.49479169
71MP0002925_abnormal_cardiovascular_devel0.46851888
72MP0003303_peritoneal_inflammation0.45985555
73MP0005319_abnormal_enzyme/_coenzyme0.43840542
74MP0003045_fibrosis0.41950285
75MP0009840_abnormal_foam_cell0.40965899
76MP0002078_abnormal_glucose_homeostasis0.40749585
77MP0001784_abnormal_fluid_regulation0.39924117
78MP0005187_abnormal_penis_morphology0.39872330
79MP0008961_abnormal_basal_metabolism0.39342778
80MP0004043_abnormal_pH_regulation0.38055833
81MP0001614_abnormal_blood_vessel0.36498902
82MP0009384_cardiac_valve_regurgitation0.35853079
83MP0003948_abnormal_gas_homeostasis0.34084393
84MP0003984_embryonic_growth_retardation0.33868443
85MP0000579_abnormal_nail_morphology0.33708032
86MP0002088_abnormal_embryonic_growth/wei0.33190938
87MP0003656_abnormal_erythrocyte_physiolo0.32339590
88MP0008569_lethality_at_weaning0.31822903
89MP0004147_increased_porphyrin_level0.31815750
90MP0005166_decreased_susceptibility_to0.30492119
91MP0008874_decreased_physiological_sensi0.28703084
92MP0005334_abnormal_fat_pad0.28303590
93MP0003879_abnormal_hair_cell0.27216208
94MP0003941_abnormal_skin_development0.25542693
95MP0005595_abnormal_vascular_smooth0.23915708
96MP0009672_abnormal_birth_weight0.23784831
97MP0003091_abnormal_cell_migration0.23468301
98MP0000762_abnormal_tongue_morphology0.23413050
99MP0009115_abnormal_fat_cell0.21954372
100MP0005535_abnormal_body_temperature0.21882278
101MP0009780_abnormal_chondrocyte_physiolo0.21753829
102MP0001299_abnormal_eye_distance/0.19288838
103MP0002295_abnormal_pulmonary_circulatio0.19025931
104MP0005452_abnormal_adipose_tissue0.18901164
105MP0002896_abnormal_bone_mineralization0.18773197
106MP0002638_abnormal_pupillary_reflex0.18225241
107MP0001958_emphysema0.18008358
108MP0002118_abnormal_lipid_homeostasis0.17364207
109MP0003075_altered_response_to0.17218513
110MP0000249_abnormal_blood_vessel0.16802503
111MP0005083_abnormal_biliary_tract0.16471747
112MP0004924_abnormal_behavior0.16438880
113MP0001727_abnormal_embryo_implantation0.15821926
114MP0002877_abnormal_melanocyte_morpholog0.15309753
115MP0005584_abnormal_enzyme/coenzyme_acti0.14706064
116MP0005376_homeostasis/metabolism_phenot0.13921948
117MP0002970_abnormal_white_adipose0.13869276

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.91726583
2Calf muscle hypertrophy (HP:0008981)6.70594337
3Exercise-induced myalgia (HP:0003738)6.64754624
4Exercise-induced muscle cramps (HP:0003710)6.45420337
5Muscle fiber splitting (HP:0003555)6.42877689
6Muscle hypertrophy of the lower extremities (HP:0008968)6.33813068
7Ventricular tachycardia (HP:0004756)6.20670234
8Abnormality of the calf musculature (HP:0001430)5.71777832
9Hyporeflexia of lower limbs (HP:0002600)5.55932651
10Abnormality of the left ventricular outflow tract (HP:0011103)5.38942806
11Subaortic stenosis (HP:0001682)5.38942806
12Atrial fibrillation (HP:0005110)5.30475430
13Muscle fiber inclusion bodies (HP:0100299)4.96925660
14Lipoatrophy (HP:0100578)4.95695908
15Primary atrial arrhythmia (HP:0001692)4.95613934
16Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.92523168
17EMG: myopathic abnormalities (HP:0003458)4.86596907
18Right ventricular cardiomyopathy (HP:0011663)4.80477030
19Supraventricular tachycardia (HP:0004755)4.78998870
20Myoglobinuria (HP:0002913)4.77778705
21Type 1 muscle fiber predominance (HP:0003803)4.77675480
22Supraventricular arrhythmia (HP:0005115)4.70098835
23Increased connective tissue (HP:0009025)4.42920331
24Syncope (HP:0001279)4.29161564
25Difficulty running (HP:0009046)4.19836500
26Dilated cardiomyopathy (HP:0001644)4.17287858
27Nemaline bodies (HP:0003798)4.13906838
28Asymmetric septal hypertrophy (HP:0001670)4.03272691
29Prolonged QT interval (HP:0001657)3.96964664
30Bundle branch block (HP:0011710)3.91651038
31Palpitations (HP:0001962)3.79256697
32Ventricular arrhythmia (HP:0004308)3.77939839
33Rhabdomyolysis (HP:0003201)3.74862295
34Myotonia (HP:0002486)3.67646565
35Difficulty climbing stairs (HP:0003551)3.44902235
36Heart block (HP:0012722)3.34602554
37Atrioventricular block (HP:0001678)3.26994482
38Ventricular fibrillation (HP:0001663)3.23786481
39Abnormal atrioventricular conduction (HP:0005150)3.18451121
40Neck muscle weakness (HP:0000467)3.17907882
41Distal arthrogryposis (HP:0005684)3.11607650
42Abnormality of skeletal muscle fiber size (HP:0012084)2.99090331
43Increased variability in muscle fiber diameter (HP:0003557)2.98033344
44Round ear (HP:0100830)2.90370379
45Muscle stiffness (HP:0003552)2.88265440
46Abnormal EKG (HP:0003115)2.84433542
47Mildly elevated creatine phosphokinase (HP:0008180)2.78509452
48Areflexia of lower limbs (HP:0002522)2.76273880
49Distal lower limb muscle weakness (HP:0009053)2.70532254
50Myopathic facies (HP:0002058)2.68456858
51Rimmed vacuoles (HP:0003805)2.60160492
52Left ventricular hypertrophy (HP:0001712)2.58135146
53Palmoplantar keratoderma (HP:0000982)2.53621037
54Absent phalangeal crease (HP:0006109)2.50253207
55EMG: neuropathic changes (HP:0003445)2.46773051
56Centrally nucleated skeletal muscle fibers (HP:0003687)2.46573664
57Limb-girdle muscle atrophy (HP:0003797)2.46052871
58Deformed tarsal bones (HP:0008119)2.37164262
59Distal lower limb amyotrophy (HP:0008944)2.36531628
60Generalized muscle weakness (HP:0003324)2.35657227
61Gowers sign (HP:0003391)2.35263903
62Scapular winging (HP:0003691)2.30183169
63Testicular atrophy (HP:0000029)2.28348073
64Muscular dystrophy (HP:0003560)2.26065360
65Ulnar deviation of the wrist (HP:0003049)2.23964188
66Abnormality of the foot musculature (HP:0001436)2.19661500
67Hypoplastic ischia (HP:0003175)2.19299189
68Ketoacidosis (HP:0001993)2.15832446
69Weak cry (HP:0001612)2.15773060
70Facial diplegia (HP:0001349)2.15122697
71Hepatic necrosis (HP:0002605)2.14136161
72Ragged-red muscle fibers (HP:0003200)2.08331372
73Abnormal mitochondria in muscle tissue (HP:0008316)2.07244445
74Fetal akinesia sequence (HP:0001989)2.06440462
75Frequent falls (HP:0002359)2.05958587
76Conjunctival hamartoma (HP:0100780)2.03694361
77Hip contracture (HP:0003273)2.02873088
78Abnormal finger flexion creases (HP:0006143)2.02450253
79Foot dorsiflexor weakness (HP:0009027)2.02348578
80Abnormality of the shoulder girdle musculature (HP:0001435)2.01282529
81Acute necrotizing encephalopathy (HP:0006965)2.01185495
82Sudden cardiac death (HP:0001645)1.95347053
83Waddling gait (HP:0002515)1.94888216
84Steppage gait (HP:0003376)1.94245418
85Hypoglycemic coma (HP:0001325)1.94105590
86Fatigable weakness (HP:0003473)1.90727660
87Abnormality of the neuromuscular junction (HP:0003398)1.90727660
88Abnormality of the ischium (HP:0003174)1.90255319
89Respiratory insufficiency due to muscle weakness (HP:0002747)1.89648024
90Progressive muscle weakness (HP:0003323)1.89192152
91Proximal amyotrophy (HP:0007126)1.87013280
92Increased muscle lipid content (HP:0009058)1.86337601
93Hepatocellular necrosis (HP:0001404)1.84985542
94Congestive heart failure (HP:0001635)1.84794910
95Spinal rigidity (HP:0003306)1.84130822
96Lower limb amyotrophy (HP:0007210)1.82065964
97Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.78935836
98Exercise intolerance (HP:0003546)1.77153590
99Bulbar palsy (HP:0001283)1.76261838
100Calcaneovalgus deformity (HP:0001848)1.75999141
101Hypoplastic heart (HP:0001961)1.75460441
102Dicarboxylic aciduria (HP:0003215)1.71286269
103Abnormality of dicarboxylic acid metabolism (HP:0010995)1.71286269
104Acute encephalopathy (HP:0006846)1.71045098
105Limb-girdle muscle weakness (HP:0003325)1.70431074
106Abnormality of fatty-acid metabolism (HP:0004359)1.70165131
107Dysmetric saccades (HP:0000641)1.68267544
108Malignant hyperthermia (HP:0002047)1.67518102
109Congenital malformation of the right heart (HP:0011723)1.66885606
110Double outlet right ventricle (HP:0001719)1.66885606
111Abnormality of the tricuspid valve (HP:0001702)1.61939917
112Aplasia of the musculature (HP:0100854)1.59658546
113Slender build (HP:0001533)1.55252919
114Type 2 muscle fiber atrophy (HP:0003554)1.52470719
115Hyperkalemia (HP:0002153)1.52228076
116Popliteal pterygium (HP:0009756)1.51649886
117Limited hip movement (HP:0008800)1.46811552
118Hypoplastic left heart (HP:0004383)1.46683768
119Diaphragmatic weakness (HP:0009113)1.46255408

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.75114150
2TTN5.72945360
3PHKG14.22926314
4PHKG24.22926314
5DMPK3.26452931
6MYLK3.22998559
7LMTK22.95512762
8MUSK2.90592038
9PDK32.83416061
10PDK42.83416061
11PKN22.76457399
12TRIB32.73593827
13PIK3CA2.28399889
14NEK12.09989203
15BCKDK1.98229337
16STK241.83038197
17PINK11.71711296
18TIE11.67006266
19PDK21.66753930
20ZAK1.54846287
21PIK3CG1.47695403
22LIMK11.36753899
23MAP3K71.31990646
24MARK11.28469931
25ILK1.27728147
26MAP2K31.20942564
27NME11.19151440
28MAPK121.17979427
29MOS1.16472672
30PRKD11.15101353
31CAMK2D1.12151669
32PAK31.09082687
33MAPKAPK31.07552901
34ROCK11.00367148
35INSRR0.97495518
36CDC42BPA0.94067420
37RIPK10.93023721
38GRK70.91548227
39MAP3K30.91283979
40TRPM70.91035755
41MAP3K50.90430504
42PRKAA10.87099394
43PRKAA20.85292611
44STK38L0.82778902
45EPHB10.78860534
46PKN10.77373633
47MAPK40.76021203
48STK40.72715313
49PDGFRA0.69889673
50FLT30.69552562
51MAP3K60.69472347
52TAOK20.68260737
53WNK40.67540901
54DAPK30.67447704
55CCNB10.65640324
56SIK10.62878584
57ROCK20.57456789
58EEF2K0.54837816
59STK380.53963916
60AKT20.53761404
61CAMK2B0.52669318
62CAMK40.52090248
63PTK2B0.51745221
64DDR20.51086980
65TBK10.49408700
66MAP2K10.49323109
67TGFBR20.47232425
68PRKACB0.47130867
69CAMK2A0.46502953
70ICK0.45440223
71PRPF4B0.45177016
72WNK10.44553156
73RPS6KC10.44287998
74RPS6KL10.44287998
75BLK0.43748605
76CAMK10.39790568
77PTK60.39353526
78NEK90.39080079
79KDR0.38485590
80DYRK1B0.37779087
81CAMK2G0.37570398
82RPS6KA60.36756077
83ZAP700.36706247
84PRKACA0.36260445
85KSR20.35449080
86LATS10.34495808
87MAP3K100.32783347
88PRKACG0.31065701
89PDPK10.29297751
90MAP2K40.28949262
91PRKCE0.28545460
92MTOR0.28092376
93NLK0.27244715
94EPHB20.26712947
95IRAK30.26396213
96SGK20.26235063
97PRKG10.25941589
98FER0.25401080
99LATS20.24894242
100MAP2K60.24416441
101ERBB30.24396714
102MAPK110.24079858
103TAOK10.23883243
104MAP3K130.22734533
105MARK30.22332455
106RPS6KA10.21756551
107PDK10.21067060
108FGFR30.20764978
109MARK20.20625897
110PRKCH0.19362430
111MAPK100.18491246
112RPS6KA30.17199697
113STK110.16983982
114FGFR40.16587304
115SGK10.16568350
116MAPK70.16276483
117JAK10.15794099
118PRKD30.15449945
119STK390.15165916
120RET0.14821663
121SGK30.13945175
122RPS6KA20.13323637
123MAP3K110.12969040
124MAP3K10.12634459
125PRKG20.12056021
126PDGFRB0.11736752
127EPHA30.11486741

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.45743194
2Cardiac muscle contraction_Homo sapiens_hsa042604.53932030
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.36104510
4Dilated cardiomyopathy_Homo sapiens_hsa054144.30417290
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.08081051
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.16044214
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.05475267
8Propanoate metabolism_Homo sapiens_hsa006402.86420863
9Parkinsons disease_Homo sapiens_hsa050122.70397702
10Fatty acid degradation_Homo sapiens_hsa000712.56160105
11Oxidative phosphorylation_Homo sapiens_hsa001902.55236760
12Carbon metabolism_Homo sapiens_hsa012002.34134722
13Alzheimers disease_Homo sapiens_hsa050102.05105243
14Viral myocarditis_Homo sapiens_hsa054161.98997092
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.98950107
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.90529086
17Fatty acid metabolism_Homo sapiens_hsa012121.90356949
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.89158169
19Pyruvate metabolism_Homo sapiens_hsa006201.61865640
20Huntingtons disease_Homo sapiens_hsa050161.59772231
21Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.36441461
22Starch and sucrose metabolism_Homo sapiens_hsa005001.34694589
23Insulin resistance_Homo sapiens_hsa049311.31575925
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27588813
25Glucagon signaling pathway_Homo sapiens_hsa049221.26768510
26Biosynthesis of amino acids_Homo sapiens_hsa012301.17617288
27Adipocytokine signaling pathway_Homo sapiens_hsa049201.15324393
28cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15201916
29Insulin signaling pathway_Homo sapiens_hsa049101.13824310
30Butanoate metabolism_Homo sapiens_hsa006501.10935062
31Fatty acid elongation_Homo sapiens_hsa000621.04321568
32PPAR signaling pathway_Homo sapiens_hsa033201.01131484
33Focal adhesion_Homo sapiens_hsa045100.95406023
34Oxytocin signaling pathway_Homo sapiens_hsa049210.91378530
35Calcium signaling pathway_Homo sapiens_hsa040200.89647112
36Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89284485
37Tight junction_Homo sapiens_hsa045300.87888868
38AMPK signaling pathway_Homo sapiens_hsa041520.87049146
39Lysine degradation_Homo sapiens_hsa003100.79818909
40HIF-1 signaling pathway_Homo sapiens_hsa040660.79190588
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77585802
42Vascular smooth muscle contraction_Homo sapiens_hsa042700.77509726
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76243378
44Galactose metabolism_Homo sapiens_hsa000520.74887420
45Arginine biosynthesis_Homo sapiens_hsa002200.73532921
46Type II diabetes mellitus_Homo sapiens_hsa049300.73072747
47Tryptophan metabolism_Homo sapiens_hsa003800.69682623
48Arginine and proline metabolism_Homo sapiens_hsa003300.66337452
49beta-Alanine metabolism_Homo sapiens_hsa004100.62750796
50ECM-receptor interaction_Homo sapiens_hsa045120.61866830
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.61492266
52Fructose and mannose metabolism_Homo sapiens_hsa000510.58389080
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55448768
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54295123
55Fatty acid biosynthesis_Homo sapiens_hsa000610.53595625
56Adherens junction_Homo sapiens_hsa045200.53162535
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52974564
58Circadian rhythm_Homo sapiens_hsa047100.52001367
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51984408
60Renin secretion_Homo sapiens_hsa049240.51685642
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51475170
62Phenylalanine metabolism_Homo sapiens_hsa003600.48535307
63Amoebiasis_Homo sapiens_hsa051460.47208732
64Insulin secretion_Homo sapiens_hsa049110.46028157
65Salivary secretion_Homo sapiens_hsa049700.45493668
66Gastric acid secretion_Homo sapiens_hsa049710.43106830
67Prion diseases_Homo sapiens_hsa050200.43100791
68cAMP signaling pathway_Homo sapiens_hsa040240.41423412
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39373522
70Long-term potentiation_Homo sapiens_hsa047200.35841166
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34159825
72Proteoglycans in cancer_Homo sapiens_hsa052050.33122215
73Peroxisome_Homo sapiens_hsa041460.32996508
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32653852
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.32255602
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31859208
77GnRH signaling pathway_Homo sapiens_hsa049120.28616003
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28356914
79Malaria_Homo sapiens_hsa051440.28150895
80Circadian entrainment_Homo sapiens_hsa047130.27571467
81mTOR signaling pathway_Homo sapiens_hsa041500.24134503
82VEGF signaling pathway_Homo sapiens_hsa043700.23618641
83Platelet activation_Homo sapiens_hsa046110.23261685
84Renal cell carcinoma_Homo sapiens_hsa052110.22467720
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20493733
86Dorso-ventral axis formation_Homo sapiens_hsa043200.17794047
87Ovarian steroidogenesis_Homo sapiens_hsa049130.16485316
88FoxO signaling pathway_Homo sapiens_hsa040680.16033313
89Osteoclast differentiation_Homo sapiens_hsa043800.15113154
90Metabolic pathways_Homo sapiens_hsa011000.14157907
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.14108427
92Tyrosine metabolism_Homo sapiens_hsa003500.14020454
93Pertussis_Homo sapiens_hsa051330.12965138
94Mineral absorption_Homo sapiens_hsa049780.12823942
95MAPK signaling pathway_Homo sapiens_hsa040100.12729621
96Melanogenesis_Homo sapiens_hsa049160.12599814
97Fat digestion and absorption_Homo sapiens_hsa049750.12419341
98Amphetamine addiction_Homo sapiens_hsa050310.12186403
99Legionellosis_Homo sapiens_hsa051340.11792652
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.11555552
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.11535333
102TNF signaling pathway_Homo sapiens_hsa046680.11316158
103Pancreatic secretion_Homo sapiens_hsa049720.11202925
104Cysteine and methionine metabolism_Homo sapiens_hsa002700.10913456
105Bile secretion_Homo sapiens_hsa049760.10564741
106Toll-like receptor signaling pathway_Homo sapiens_hsa046200.10053320
107Jak-STAT signaling pathway_Homo sapiens_hsa046300.09941746
108Gap junction_Homo sapiens_hsa045400.09761986
109Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.09691006
110Pentose phosphate pathway_Homo sapiens_hsa000300.09368069
111Cholinergic synapse_Homo sapiens_hsa047250.09231638
112Notch signaling pathway_Homo sapiens_hsa043300.07901139
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.07111932
114Toxoplasmosis_Homo sapiens_hsa051450.06837887
115Small cell lung cancer_Homo sapiens_hsa052220.04836137
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.02158937
117Acute myeloid leukemia_Homo sapiens_hsa05221-0.0054959

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