XIRP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of skeletal muscle contraction (GO:0014819)9.57376308
2sarcomere organization (GO:0045214)9.22577902
3actin-myosin filament sliding (GO:0033275)8.89895681
4muscle filament sliding (GO:0030049)8.89895681
5positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)8.78826491
6regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)7.88093517
7sarcoplasmic reticulum calcium ion transport (GO:0070296)7.86186396
8actin-mediated cell contraction (GO:0070252)7.40914744
9myofibril assembly (GO:0030239)7.31957678
10regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO7.25685398
11cardiac myofibril assembly (GO:0055003)7.19188724
12plasma membrane repair (GO:0001778)7.03302262
13regulation of relaxation of muscle (GO:1901077)6.58093407
14negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.57490539
15regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)6.44479241
16regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)6.41363530
17cardiac muscle contraction (GO:0060048)6.21123906
18carnitine shuttle (GO:0006853)5.95943831
19cardiac muscle cell development (GO:0055013)5.87925228
20actomyosin structure organization (GO:0031032)5.86122267
21striated muscle contraction (GO:0006941)5.84173511
22regulation of cell communication by electrical coupling (GO:0010649)5.83885037
23skeletal muscle contraction (GO:0003009)5.65919120
24actin filament-based movement (GO:0030048)5.64987416
25negative regulation of potassium ion transmembrane transport (GO:1901380)5.58450062
26skeletal muscle fiber development (GO:0048741)5.57616307
27cardiac muscle hypertrophy (GO:0003300)5.55613016
28cardiac cell development (GO:0055006)5.50622191
29striated muscle hypertrophy (GO:0014897)5.39853092
30regulation of actin filament-based movement (GO:1903115)5.39624522
31response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.37110418
32skeletal muscle adaptation (GO:0043501)5.24506034
33fatty acid transmembrane transport (GO:1902001)5.15140198
34ventricular cardiac muscle cell action potential (GO:0086005)5.09834216
35cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.07312305
36regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.04036695
37tricarboxylic acid cycle (GO:0006099)4.94439036
38regulation of striated muscle contraction (GO:0006942)4.92271240
39NADH metabolic process (GO:0006734)4.88840470
40muscle hypertrophy (GO:0014896)4.77236251
41creatine metabolic process (GO:0006600)4.74323419
42bundle of His cell to Purkinje myocyte communication (GO:0086069)4.74032688
43regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.66643143
44regulation of acyl-CoA biosynthetic process (GO:0050812)4.60033449
45skeletal muscle tissue development (GO:0007519)4.57073195
46cell communication involved in cardiac conduction (GO:0086065)4.49841905
47adult heart development (GO:0007512)4.44878142
48* cardiac muscle tissue morphogenesis (GO:0055008)4.44128327
49positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.42210527
50carnitine transmembrane transport (GO:1902603)4.40877701
51muscle contraction (GO:0006936)4.34089668
52cell communication by electrical coupling (GO:0010644)4.31117606
53response to inactivity (GO:0014854)4.27192308
54regulation of cofactor metabolic process (GO:0051193)4.15529078
55regulation of coenzyme metabolic process (GO:0051196)4.15529078
56* muscle tissue morphogenesis (GO:0060415)4.12685398
57regulation of sarcomere organization (GO:0060297)4.11824181
58cardiac muscle cell action potential (GO:0086001)4.09766187
59striated muscle cell development (GO:0055002)4.08879686
60muscle fiber development (GO:0048747)4.05335022
61regulation of membrane repolarization (GO:0060306)4.04928282
62amino-acid betaine transport (GO:0015838)4.01874445
63carnitine transport (GO:0015879)4.01874445
64muscle system process (GO:0003012)3.96888354
65heart contraction (GO:0060047)3.91125533
66heart process (GO:0003015)3.91125533
67response to muscle activity (GO:0014850)3.87858699
68regulation of calcium ion transmembrane transporter activity (GO:1901019)3.87621283
69regulation of calcium ion transmembrane transport (GO:1903169)3.87621283
70striated muscle atrophy (GO:0014891)3.85081113
71glycogen catabolic process (GO:0005980)3.82719324
72regulation of cardiac muscle contraction (GO:0055117)3.82559787
73striated muscle adaptation (GO:0014888)3.82410203
74ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.76991302
75positive regulation of cation channel activity (GO:2001259)3.76869950
76muscle adaptation (GO:0043500)3.75066219
77cardiac muscle cell action potential involved in contraction (GO:0086002)3.72798852
78muscle structure development (GO:0061061)3.70865104
79muscle organ development (GO:0007517)3.68393749
80glycogen metabolic process (GO:0005977)3.67715271
81pyrimidine ribonucleoside catabolic process (GO:0046133)3.65978938
82negative regulation of calcium ion transmembrane transport (GO:1903170)3.65929563
83negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.65929563
84detection of calcium ion (GO:0005513)3.61305096
85muscle cell fate commitment (GO:0042693)3.61003404
86negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.60689418
87glucan metabolic process (GO:0044042)3.60434793
88cellular glucan metabolic process (GO:0006073)3.60434793
89muscle hypertrophy in response to stress (GO:0003299)3.58613541
90cardiac muscle adaptation (GO:0014887)3.58613541
91cardiac muscle hypertrophy in response to stress (GO:0014898)3.58613541
92glucan catabolic process (GO:0009251)3.56717443
93muscle cell cellular homeostasis (GO:0046716)3.51865659
94muscle cell development (GO:0055001)3.47623302
95regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.47014899
96skeletal muscle tissue regeneration (GO:0043403)3.42896121
97regulation of sulfur metabolic process (GO:0042762)3.42811802
98relaxation of muscle (GO:0090075)3.39961524
99positive regulation of myotube differentiation (GO:0010831)3.39204674
100negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.38110290
101regulation of heart rate (GO:0002027)3.37709107
102response to activity (GO:0014823)3.35576589
103cellular polysaccharide catabolic process (GO:0044247)3.34309965
104myotube differentiation (GO:0014902)3.32750744
105membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.32437150
106regulation of cardiac muscle cell contraction (GO:0086004)3.32406471
107regulation of skeletal muscle cell differentiation (GO:2001014)3.31470619
108regulation of myoblast differentiation (GO:0045661)3.30941086
109glucan biosynthetic process (GO:0009250)3.29927736
110glycogen biosynthetic process (GO:0005978)3.29927736
111regulation of muscle contraction (GO:0006937)3.29700530
112muscle atrophy (GO:0014889)3.28816336
113myotube cell development (GO:0014904)3.28578838
114heart trabecula formation (GO:0060347)3.27829456
1152-oxoglutarate metabolic process (GO:0006103)3.27482088
116response to caffeine (GO:0031000)3.25047556
117striated muscle tissue development (GO:0014706)3.24910190
118regulation of the force of heart contraction (GO:0002026)3.23983848
119gluconeogenesis (GO:0006094)3.23136432
120relaxation of cardiac muscle (GO:0055119)3.22558968
121regulation of ATPase activity (GO:0043462)3.22131861
122regulation of ATP catabolic process (GO:1903289)3.22131861
123regulation of muscle system process (GO:0090257)3.19431221
124polysaccharide catabolic process (GO:0000272)3.17522211
125cytidine deamination (GO:0009972)3.16450238
126cytidine catabolic process (GO:0006216)3.16450238

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.82908110
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.36208130
3EP300_21415370_ChIP-Seq_HL-1_Mouse4.21803135
4TBX20_22328084_ChIP-Seq_HEART_Mouse3.71916879
5TBX20_22080862_ChIP-Seq_HEART_Mouse3.71916879
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.12474985
7ZNF263_19887448_ChIP-Seq_K562_Human3.09908670
8ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.03419839
9MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.97164396
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.96293059
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.56936472
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.52456333
13CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.43052908
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.38100875
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.31204927
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.25256683
17EZH2_22144423_ChIP-Seq_EOC_Human2.20017939
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.11464774
19GATA4_21415370_ChIP-Seq_HL-1_Mouse1.99827683
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.87988029
21GBX2_23144817_ChIP-Seq_PC3_Human1.65769808
22EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.65351887
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.64338523
24BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.64091577
25DROSHA_22980978_ChIP-Seq_HELA_Human1.62273103
26NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.54630406
27EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.53531530
28TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.50680322
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.44689931
30CTCF_27219007_Chip-Seq_Bcells_Human1.41016410
31ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39506594
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.37332655
33CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.30538972
34CLOCK_20551151_ChIP-Seq_293T_Human1.29648472
35ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28872708
36PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.27335415
37GATA1_22025678_ChIP-Seq_K562_Human1.25994538
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24417444
39TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23125829
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20872957
41TP63_17297297_ChIP-ChIP_HaCaT_Human1.19331001
42SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.19290149
43LXR_22158963_ChIP-Seq_LIVER_Mouse1.18269372
44PPARA_22158963_ChIP-Seq_LIVER_Mouse1.17931435
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17551284
46BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16149372
47PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15801396
48CTNNB1_20460455_ChIP-Seq_HCT116_Human1.14991232
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.14175363
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.13784689
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12816116
52BCAT_22108803_ChIP-Seq_LS180_Human1.11751882
53FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11343659
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11269637
55CJUN_26792858_Chip-Seq_BT549_Human1.10491367
56VDR_22108803_ChIP-Seq_LS180_Human1.09556452
57SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08389736
58KDM2B_26808549_Chip-Seq_DND41_Human1.07739902
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07651985
60CRX_20693478_ChIP-Seq_RETINA_Mouse1.07638545
61SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07118795
62IGF1R_20145208_ChIP-Seq_DFB_Human1.06572015
63RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04955926
64NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.04309377
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.03500086
66OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02184124
67SOX2_21211035_ChIP-Seq_LN229_Gbm1.02168900
68FOXA2_19822575_ChIP-Seq_HepG2_Human1.01975839
69CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01726184
70PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01615949
71TP63_22573176_ChIP-Seq_HFKS_Human1.00389952
72ZNF274_21170338_ChIP-Seq_K562_Hela0.97382607
73ISL1_27105846_Chip-Seq_CPCs_Mouse0.96504231
74RXR_22158963_ChIP-Seq_LIVER_Mouse0.94933764
75AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92899201
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92773044
77CBX2_27304074_Chip-Seq_ESCs_Mouse0.92666431
78SMAD3_21741376_ChIP-Seq_HESCs_Human0.92347324
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91178453
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91012300
81SMC3_22415368_ChIP-Seq_MEFs_Mouse0.90950763
82FOXH1_21741376_ChIP-Seq_ESCs_Human0.89998125
83GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.89929908
84RARB_27405468_Chip-Seq_BRAIN_Mouse0.89446099
85* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89381761
86SMAD4_21741376_ChIP-Seq_HESCs_Human0.88946181
87ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88367877
88TCF4_18268006_ChIP-ChIP_LS174T_Human0.87981657
89RACK7_27058665_Chip-Seq_MCF-7_Human0.87857295
90GATA1_19941826_ChIP-Seq_K562_Human0.87144218
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86344268
92HTT_18923047_ChIP-ChIP_STHdh_Human0.86255487
93AR_21572438_ChIP-Seq_LNCaP_Human0.85786295
94OCT4_20526341_ChIP-Seq_ESCs_Human0.85736211
95CTCF_21964334_ChIP-Seq_BJAB-B_Human0.85511178
96ER_23166858_ChIP-Seq_MCF-7_Human0.84503257
97RUNX1_27514584_Chip-Seq_MCF-7_Human0.83956081
98NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83901816
99NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83901816
100SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83674215
101KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83191646
102SMAD4_21799915_ChIP-Seq_A2780_Human0.82679998
103ATF3_27146783_Chip-Seq_COLON_Human0.82650680
104GATA2_19941826_ChIP-Seq_K562_Human0.82115147
105TBL1_22424771_ChIP-Seq_293T_Human0.81958145
106P63_26484246_Chip-Seq_KERATINOCYTES_Human0.81192073
107STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.80859975
108PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.80828686
109WT1_25993318_ChIP-Seq_PODOCYTE_Human0.80496190
110TP53_16413492_ChIP-PET_HCT116_Human0.80091591
111PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.79074881
112MTF2_20144788_ChIP-Seq_MESCs_Mouse0.78862985
113AHR_22903824_ChIP-Seq_MCF-7_Human0.78307103
114SPI1_20517297_ChIP-Seq_HL60_Human0.78276169
115CBP_21632823_ChIP-Seq_H3396_Human0.77103159
116MYC_27129775_Chip-Seq_CORNEA_Mouse0.77017462
117EZH2_27294783_Chip-Seq_ESCs_Mouse0.76960224
118NR3C1_21868756_ChIP-Seq_MCF10A_Human0.76407417
119GF1_26923725_Chip-Seq_HPCs_Mouse0.76127830
120CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.76106242
121JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76024754
122STAT6_21828071_ChIP-Seq_BEAS2B_Human0.75870876
123NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.75579694
124LXR_22292898_ChIP-Seq_THP-1_Human0.75573041
125TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75043939
126NFIB_24661679_ChIP-Seq_LUNG_Mouse0.75005775
127TP53_23651856_ChIP-Seq_MEFs_Mouse0.74965683
128GATA1_19941827_ChIP-Seq_MEL_Mouse0.74750941
129GATA1_19941827_ChIP-Seq_MEL86_Mouse0.73949361
130NANOG_19829295_ChIP-Seq_ESCs_Human0.73739618
131SOX2_19829295_ChIP-Seq_ESCs_Human0.73739618
132TRIM28_21343339_ChIP-Seq_HEK293_Human0.73549161
133P53_22127205_ChIP-Seq_FIBROBLAST_Human0.73330678
134TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.73273839
135DNAJC2_21179169_ChIP-ChIP_NT2_Human0.73118515
136NFYB_21822215_ChIP-Seq_K562_Human0.69624462
137PHF8_20622853_ChIP-Seq_HELA_Human0.69541672
138POU3F2_20337985_ChIP-ChIP_501MEL_Human0.68651664
139* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.68323127
140PCGF2_27294783_Chip-Seq_NPCs_Mouse0.68198931
141GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.68192783

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy6.15494271
2MP0002837_dystrophic_cardiac_calcinosis5.88861658
3MP0003646_muscle_fatigue5.59529342
4MP0000749_muscle_degeneration5.16543603
5MP0004145_abnormal_muscle_electrophysio4.66496161
6MP0004215_abnormal_myocardial_fiber4.26475681
7MP0004084_abnormal_cardiac_muscle4.23915055
8MP0004036_abnormal_muscle_relaxation3.90775024
9MP0005330_cardiomyopathy3.50535545
10* MP0004087_abnormal_muscle_fiber3.34757659
11MP0000750_abnormal_muscle_regeneration3.34737048
12MP0002106_abnormal_muscle_physiology3.31341181
13MP0000747_muscle_weakness3.11641308
14MP0002269_muscular_atrophy3.02345399
15MP0004130_abnormal_muscle_cell2.95887656
16MP0005620_abnormal_muscle_contractility2.94700624
17MP0004510_myositis2.88148158
18MP0005369_muscle_phenotype2.69420213
19MP0000759_abnormal_skeletal_muscle2.68120009
20MP0002972_abnormal_cardiac_muscle2.58946763
21MP0003137_abnormal_impulse_conducting2.45202582
22MP0008775_abnormal_heart_ventricle2.38577831
23MP0004484_altered_response_of2.37970197
24* MP0010630_abnormal_cardiac_muscle2.25673909
25MP0003950_abnormal_plasma_membrane2.01096735
26* MP0005385_cardiovascular_system_phenoty1.97366809
27* MP0001544_abnormal_cardiovascular_syste1.97366809
28MP0004233_abnormal_muscle_weight1.91196942
29MP0002127_abnormal_cardiovascular_syste1.75958410
30MP0002332_abnormal_exercise_endurance1.58393982
31MP0006036_abnormal_mitochondrial_physio1.58070932
32MP0004085_abnormal_heartbeat1.55160976
33MP0006138_congestive_heart_failure1.48634820
34MP0005666_abnormal_adipose_tissue1.44608362
35MP0003828_pulmonary_edema1.43524576
36MP0005670_abnormal_white_adipose1.41259751
37MP0002108_abnormal_muscle_morphology1.37724165
38MP0000733_abnormal_muscle_development1.33345443
39* MP0003221_abnormal_cardiomyocyte_apopto1.30915923
40MP0003045_fibrosis1.26056914
41MP0004185_abnormal_adipocyte_glucose1.15618568
42MP0000343_altered_response_to1.03670645
43MP0005375_adipose_tissue_phenotype0.97810334
44MP0006035_abnormal_mitochondrial_morpho0.97782870
45* MP0000266_abnormal_heart_morphology0.94146171
46MP0003567_abnormal_fetal_cardiomyocyte0.93849587
47MP0005165_increased_susceptibility_to0.82510537
48MP0002971_abnormal_brown_adipose0.79954280
49MP0005266_abnormal_metabolism0.76350762
50MP0010368_abnormal_lymphatic_system0.75385487
51MP0000372_irregular_coat_pigmentation0.71470819
52MP0002234_abnormal_pharynx_morphology0.69445514
53MP0000013_abnormal_adipose_tissue0.68574756
54MP0002822_catalepsy0.68050284
55MP0003705_abnormal_hypodermis_morpholog0.66466054
56MP0005275_abnormal_skin_tensile0.65890102
57* MP0002128_abnormal_blood_circulation0.61462486
58MP0003806_abnormal_nucleotide_metabolis0.58530126
59MP0003879_abnormal_hair_cell0.54088128
60MP0005623_abnormal_meninges_morphology0.53923198
61MP0003566_abnormal_cell_adhesion0.53599163
62MP0000230_abnormal_systemic_arterial0.53534285
63MP0003279_aneurysm0.52973211
64MP0004134_abnormal_chest_morphology0.50295337
65MP0000003_abnormal_adipose_tissue0.50287121
66MP0004043_abnormal_pH_regulation0.49762869
67MP0004147_increased_porphyrin_level0.48798601
68MP0002078_abnormal_glucose_homeostasis0.47178737
69MP0008961_abnormal_basal_metabolism0.46822353
70MP0001299_abnormal_eye_distance/0.46466812
71MP0005334_abnormal_fat_pad0.44184452
72MP0001879_abnormal_lymphatic_vessel0.43846372
73MP0005319_abnormal_enzyme/_coenzyme0.42528667
74MP0005167_abnormal_blood-brain_barrier0.42512975
75MP0002909_abnormal_adrenal_gland0.42483514
76MP0009780_abnormal_chondrocyte_physiolo0.42376917
77MP0001661_extended_life_span0.41357275
78MP0002638_abnormal_pupillary_reflex0.40596941
79MP0008438_abnormal_cutaneous_collagen0.39703432
80MP0004142_abnormal_muscle_tone0.38442829
81MP0000767_abnormal_smooth_muscle0.38426472
82MP0002168_other_aberrant_phenotype0.36391971
83MP0005376_homeostasis/metabolism_phenot0.33494044
84MP0005187_abnormal_penis_morphology0.32697042
85MP0002925_abnormal_cardiovascular_devel0.32588470
86MP0003948_abnormal_gas_homeostasis0.30310436
87MP0005535_abnormal_body_temperature0.29770721
88MP0002114_abnormal_axial_skeleton0.28442954
89MP0000579_abnormal_nail_morphology0.28290187
90MP0005423_abnormal_somatic_nervous0.27748320
91MP0005166_decreased_susceptibility_to0.27686541
92MP0009115_abnormal_fat_cell0.27489437
93MP0002734_abnormal_mechanical_nocicepti0.26558289
94MP0000762_abnormal_tongue_morphology0.26371946
95MP0001784_abnormal_fluid_regulation0.26084102
96MP0002896_abnormal_bone_mineralization0.25320798
97MP0003656_abnormal_erythrocyte_physiolo0.25214301
98MP0001614_abnormal_blood_vessel0.24685092
99MP0005452_abnormal_adipose_tissue0.23411127
100MP0005451_abnormal_body_composition0.23022017
101MP0001984_abnormal_olfaction0.22659031
102MP0002118_abnormal_lipid_homeostasis0.22019228
103MP0004270_analgesia0.21081604
104MP0005584_abnormal_enzyme/coenzyme_acti0.20733295
105MP0009250_abnormal_appendicular_skeleto0.20596080
106MP0006276_abnormal_autonomic_nervous0.20135834
107MP0001943_abnormal_respiration0.19704969
108MP0005332_abnormal_amino_acid0.19255166
109MP0010030_abnormal_orbit_morphology0.18388808
110MP0005386_behavior/neurological_phenoty0.16908246
111MP0004924_abnormal_behavior0.16908246
112MP0008569_lethality_at_weaning0.16608001
113MP0001853_heart_inflammation0.16252319
114MP0004272_abnormal_basement_membrane0.16144275
115* MP0002066_abnormal_motor_capabilities/c0.15971271
116MP0003984_embryonic_growth_retardation0.15603200
117MP0002876_abnormal_thyroid_physiology0.14697473
118MP0002088_abnormal_embryonic_growth/wei0.14519864
119MP0008874_decreased_physiological_sensi0.14361168
120MP0003195_calcinosis0.14233834
121MP0003941_abnormal_skin_development0.12464212
122MP0005083_abnormal_biliary_tract0.12419139
123MP0004197_abnormal_fetal_growth/weight/0.10951383

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.29139014
2Exercise-induced myalgia (HP:0003738)7.02631890
3Calf muscle hypertrophy (HP:0008981)7.00573143
4Muscle hypertrophy of the lower extremities (HP:0008968)6.94971875
5Muscle fiber splitting (HP:0003555)6.85947090
6Exercise-induced muscle cramps (HP:0003710)6.58702645
7Muscle fiber inclusion bodies (HP:0100299)6.51143381
8Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.36095652
9Hyporeflexia of lower limbs (HP:0002600)5.76723099
10Abnormality of the calf musculature (HP:0001430)5.74042308
11Nemaline bodies (HP:0003798)5.46947830
12Ventricular tachycardia (HP:0004756)5.44748176
13Type 1 muscle fiber predominance (HP:0003803)5.03375763
14Myoglobinuria (HP:0002913)5.01476444
15EMG: myopathic abnormalities (HP:0003458)4.95495159
16Difficulty running (HP:0009046)4.91285158
17Increased connective tissue (HP:0009025)4.83442042
18Right ventricular cardiomyopathy (HP:0011663)4.72984093
19Atrial fibrillation (HP:0005110)4.61103512
20Primary atrial arrhythmia (HP:0001692)4.30049069
21Lipoatrophy (HP:0100578)4.27652424
22Supraventricular tachycardia (HP:0004755)4.14411452
23Distal arthrogryposis (HP:0005684)4.05391838
24Supraventricular arrhythmia (HP:0005115)4.04952142
25Syncope (HP:0001279)4.03970925
26Abnormality of the left ventricular outflow tract (HP:0011103)3.96747194
27Subaortic stenosis (HP:0001682)3.96747194
28Rhabdomyolysis (HP:0003201)3.91394103
29Myotonia (HP:0002486)3.88992899
30Round ear (HP:0100830)3.84486439
31Myopathic facies (HP:0002058)3.81197232
32Difficulty climbing stairs (HP:0003551)3.77607499
33Dilated cardiomyopathy (HP:0001644)3.67585700
34Bundle branch block (HP:0011710)3.65553810
35Rimmed vacuoles (HP:0003805)3.41007275
36Muscle stiffness (HP:0003552)3.37031446
37Abnormality of skeletal muscle fiber size (HP:0012084)3.32025273
38Prolonged QT interval (HP:0001657)3.31584996
39Ventricular arrhythmia (HP:0004308)3.30559947
40Ulnar deviation of the wrist (HP:0003049)3.29759990
41Increased variability in muscle fiber diameter (HP:0003557)3.29045970
42Asymmetric septal hypertrophy (HP:0001670)3.26833796
43Neck muscle weakness (HP:0000467)3.26358364
44Areflexia of lower limbs (HP:0002522)3.24416128
45Palpitations (HP:0001962)3.14370786
46Heart block (HP:0012722)3.04092931
47Abnormal atrioventricular conduction (HP:0005150)2.88751898
48Muscular dystrophy (HP:0003560)2.84673174
49Atrioventricular block (HP:0001678)2.72805386
50Hypoplastic ischia (HP:0003175)2.72147137
51Distal lower limb muscle weakness (HP:0009053)2.71056404
52Fetal akinesia sequence (HP:0001989)2.70646070
53Calcaneovalgus deformity (HP:0001848)2.68602028
54Facial diplegia (HP:0001349)2.59315568
55Slender build (HP:0001533)2.55942758
56Mildly elevated creatine phosphokinase (HP:0008180)2.51654023
57Absent phalangeal crease (HP:0006109)2.48965499
58Distal lower limb amyotrophy (HP:0008944)2.48810246
59Gowers sign (HP:0003391)2.43665638
60Deformed tarsal bones (HP:0008119)2.42593732
61Frequent falls (HP:0002359)2.38677306
62Abnormality of the ischium (HP:0003174)2.37552791
63Abnormal EKG (HP:0003115)2.36949936
64Centrally nucleated skeletal muscle fibers (HP:0003687)2.35022450
65Ventricular fibrillation (HP:0001663)2.34965326
66EMG: neuropathic changes (HP:0003445)2.31981726
67Weak cry (HP:0001612)2.25949644
68Proximal amyotrophy (HP:0007126)2.23306594
69Testicular atrophy (HP:0000029)2.23184342
70Generalized muscle weakness (HP:0003324)2.23053426
71Scapular winging (HP:0003691)2.22006923
72Hip contracture (HP:0003273)2.21935646
73Limb-girdle muscle atrophy (HP:0003797)2.21342653
74Palmoplantar keratoderma (HP:0000982)2.12421574
75Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.11100418
76Left ventricular hypertrophy (HP:0001712)2.07371547
77Ketoacidosis (HP:0001993)2.06797538
78Abnormal finger flexion creases (HP:0006143)2.01873246
79Abnormality of the calcaneus (HP:0008364)2.01231797
80Fatigable weakness (HP:0003473)1.98505646
81Abnormality of the neuromuscular junction (HP:0003398)1.98505646
82Foot dorsiflexor weakness (HP:0009027)1.98314029
83Progressive muscle weakness (HP:0003323)1.95380229
84Abnormality of the foot musculature (HP:0001436)1.93929652
85Lower limb amyotrophy (HP:0007210)1.92042895
86Ragged-red muscle fibers (HP:0003200)1.88618218
87Respiratory insufficiency due to muscle weakness (HP:0002747)1.88615633
88Hypoglycemic coma (HP:0001325)1.88395158
89Limited hip movement (HP:0008800)1.84707628
90Long clavicles (HP:0000890)1.83236486
91Toxemia of pregnancy (HP:0100603)1.83191606
92Hyperkalemia (HP:0002153)1.82912877
93Malignant hyperthermia (HP:0002047)1.82565723
94Insulin-resistant diabetes mellitus (HP:0000831)1.81901852
95Abnormality of the musculature of the pelvis (HP:0001469)1.81240492
96Abnormality of the hip-girdle musculature (HP:0001445)1.81240492
97Sudden cardiac death (HP:0001645)1.78032654
98Bulbar palsy (HP:0001283)1.77559592
99Limb-girdle muscle weakness (HP:0003325)1.76333876
100Pelvic girdle muscle weakness (HP:0003749)1.75211310
101Shoulder girdle muscle weakness (HP:0003547)1.74904730
102Hyperglycemia (HP:0003074)1.74597159
103Waddling gait (HP:0002515)1.74003737
104Spinal rigidity (HP:0003306)1.72989530
105Oligomenorrhea (HP:0000876)1.71150378
106Diaphragmatic weakness (HP:0009113)1.70949069
107Abnormality of the shoulder girdle musculature (HP:0001435)1.68476103
108Abnormal mitochondria in muscle tissue (HP:0008316)1.67681094
109Hepatic necrosis (HP:0002605)1.67129489
110Exercise intolerance (HP:0003546)1.66088494
111Nonprogressive disorder (HP:0003680)1.66006423
112Steppage gait (HP:0003376)1.65792296
113Cholelithiasis (HP:0001081)1.61981807
114Hyperinsulinemic hypoglycemia (HP:0000825)1.61892117
115Hypoalphalipoproteinemia (HP:0003233)1.61798010
116Type 2 muscle fiber atrophy (HP:0003554)1.61315858
117Popliteal pterygium (HP:0009756)1.58891057
118Paralysis (HP:0003470)1.53818971
119Muscle fiber atrophy (HP:0100295)1.45321357

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN8.99299069
2TTN5.62152549
3PHKG14.42602011
4PHKG24.42602011
5DMPK2.99536295
6MUSK2.91048762
7PDK42.64378989
8PDK32.64378989
9ZAK2.55768485
10PIK3CG2.26252135
11LMTK21.98333431
12NME11.96148746
13PINK11.93530100
14TRIB31.90970407
15PIK3CA1.86751387
16INSRR1.81533560
17NEK11.80377809
18PKN21.68713851
19PDK21.62146179
20BCKDK1.59947433
21MAP3K71.55124621
22MYLK1.47623175
23MAP2K31.45472316
24MARK11.23608950
25TIE11.17422426
26MAPK121.16130632
27CAMK2D1.11532840
28LIMK11.07709923
29GRK71.05425233
30CCNB11.00536889
31EEF2K0.96257954
32PRKD10.96224519
33PRKAA20.93836835
34MAP3K30.91643676
35STK240.90717279
36PRKAA10.89591536
37ILK0.86314888
38EPHB10.85763508
39PKN10.83356004
40SIK10.82571030
41TRPM70.76654053
42MOS0.76099055
43ERBB30.75654667
44RIPK10.74392892
45MAPKAPK30.66569093
46ROCK10.65469900
47MAP2K40.64919516
48PAK30.63137242
49AKT20.62665485
50NEK90.59756956
51MAP3K50.58671785
52MAP3K130.50996698
53LATS10.48629956
54CAMK2B0.46969504
55CAMK40.46723978
56WNK10.46065885
57MAP2K60.45765179
58STK38L0.45736730
59DYRK1B0.45365525
60MAP2K10.43103315
61PDGFRA0.42815492
62CAMK2A0.40917552
63STK380.40568778
64PRKACB0.40550124
65CAMK2G0.39359580
66SGK20.38964200
67KSR20.37201979
68FLT30.36290617
69PRKACA0.35861665
70CAMK1G0.35769315
71WNK40.33521267
72PRKG10.33092735
73CDC42BPA0.33031053
74ROCK20.32111120
75PRKACG0.30754730
76CAMK10.30393479
77PTK60.29294829
78STK40.29062151
79TBK10.28636497
80TGFBR20.27705587
81PTK2B0.26959402
82MAPK110.26415081
83MARK20.25926690
84SGK10.24391230
85RPS6KB10.23981807
86JAK10.23223183
87RPS6KA30.22049360
88MAPK100.21796848
89LATS20.21433583
90MTOR0.21228970
91NLK0.21225913
92PDPK10.20633685
93TAOK10.20188976
94ICK0.19884438
95SGK30.19581906
96PDGFRB0.19283104
97CAMK1D0.18624880
98MAP3K100.18375645
99ZAP700.17486809
100PDK10.16967443
101MAPK130.16889910
102SGK2230.16803225
103SGK4940.16803225
104MARK30.16719077
105RPS6KA10.16510797
106RPS6KB20.15952438
107PRKCE0.15673767
108RPS6KL10.15565031
109RPS6KC10.15565031
110PRKCH0.14853360
111MAPK70.14802987
112FGFR40.14097924
113FER0.13766428
114RET0.13651816
115TAOK20.12550499
116KDR0.12428513
117MAP3K10.11112904
118EPHA30.11007863
119FGFR30.10376085
120DAPK30.10154644
121MAP3K60.10037987
122MAPK40.09360310
123STK110.09345388
124DAPK20.09098868
125RPS6KA60.09012959
126PAK60.07856764
127PRPF4B0.07626524
128PRKG20.07573595
129RAF10.06172259
130MAPK90.04009948

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.94965044
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.50245338
3Dilated cardiomyopathy_Homo sapiens_hsa054144.28163530
4Cardiac muscle contraction_Homo sapiens_hsa042604.05084498
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.61622524
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.59094582
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.95878817
8Propanoate metabolism_Homo sapiens_hsa006402.90142434
9Fatty acid degradation_Homo sapiens_hsa000712.40764847
10Parkinsons disease_Homo sapiens_hsa050122.15309503
11Carbon metabolism_Homo sapiens_hsa012002.14760237
12Oxidative phosphorylation_Homo sapiens_hsa001902.02386683
13Viral myocarditis_Homo sapiens_hsa054161.99390148
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.90656039
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.89511682
16Fatty acid metabolism_Homo sapiens_hsa012121.81652761
17Alzheimers disease_Homo sapiens_hsa050101.79396417
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.70908882
19Starch and sucrose metabolism_Homo sapiens_hsa005001.62094117
20Insulin resistance_Homo sapiens_hsa049311.60987650
21Pyruvate metabolism_Homo sapiens_hsa006201.56047868
22Glucagon signaling pathway_Homo sapiens_hsa049221.49154031
23Insulin signaling pathway_Homo sapiens_hsa049101.44120849
24Adipocytokine signaling pathway_Homo sapiens_hsa049201.38885195
25Oxytocin signaling pathway_Homo sapiens_hsa049211.36141363
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.30774944
27Calcium signaling pathway_Homo sapiens_hsa040201.23779577
28cGMP-PKG signaling pathway_Homo sapiens_hsa040221.21682718
29Huntingtons disease_Homo sapiens_hsa050161.17820462
30AMPK signaling pathway_Homo sapiens_hsa041521.12474979
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10654747
32Circadian rhythm_Homo sapiens_hsa047101.06031216
33Type II diabetes mellitus_Homo sapiens_hsa049301.05647764
34Butanoate metabolism_Homo sapiens_hsa006501.05558449
35PPAR signaling pathway_Homo sapiens_hsa033201.02690190
36Biosynthesis of amino acids_Homo sapiens_hsa012301.00792821
37Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99436175
38Nitrogen metabolism_Homo sapiens_hsa009100.98708489
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90756817
40Vascular smooth muscle contraction_Homo sapiens_hsa042700.90747984
41Focal adhesion_Homo sapiens_hsa045100.88407867
42Lysine degradation_Homo sapiens_hsa003100.85630588
43Fatty acid elongation_Homo sapiens_hsa000620.85162118
44Galactose metabolism_Homo sapiens_hsa000520.82967193
45Renin secretion_Homo sapiens_hsa049240.80429311
46Arginine and proline metabolism_Homo sapiens_hsa003300.78215583
47Tight junction_Homo sapiens_hsa045300.76962868
48HIF-1 signaling pathway_Homo sapiens_hsa040660.75189118
49Arginine biosynthesis_Homo sapiens_hsa002200.74382216
50Insulin secretion_Homo sapiens_hsa049110.74323285
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72591587
52Fatty acid biosynthesis_Homo sapiens_hsa000610.69116158
53beta-Alanine metabolism_Homo sapiens_hsa004100.68036636
54Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67196980
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66196482
56Fructose and mannose metabolism_Homo sapiens_hsa000510.66030113
57Gastric acid secretion_Homo sapiens_hsa049710.62767958
58Adherens junction_Homo sapiens_hsa045200.61321593
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60538758
60Tryptophan metabolism_Homo sapiens_hsa003800.58748247
61Circadian entrainment_Homo sapiens_hsa047130.56011706
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.55163118
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54217468
64GnRH signaling pathway_Homo sapiens_hsa049120.49992734
65cAMP signaling pathway_Homo sapiens_hsa040240.49095516
66ECM-receptor interaction_Homo sapiens_hsa045120.48109662
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47856069
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46012959
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44627759
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44155634
71Regulation of autophagy_Homo sapiens_hsa041400.44037766
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42218998
73mTOR signaling pathway_Homo sapiens_hsa041500.42100130
74Phenylalanine metabolism_Homo sapiens_hsa003600.39967491
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37420443
76FoxO signaling pathway_Homo sapiens_hsa040680.36988123
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36261336
78Amoebiasis_Homo sapiens_hsa051460.35579379
79Long-term depression_Homo sapiens_hsa047300.34649087
80VEGF signaling pathway_Homo sapiens_hsa043700.34198500
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32491187
82Proteoglycans in cancer_Homo sapiens_hsa052050.32314302
83Platelet activation_Homo sapiens_hsa046110.31569195
84Dorso-ventral axis formation_Homo sapiens_hsa043200.30899095
85Peroxisome_Homo sapiens_hsa041460.28103800
86MAPK signaling pathway_Homo sapiens_hsa040100.27899694
87Cholinergic synapse_Homo sapiens_hsa047250.27691121
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.26818267
89Renal cell carcinoma_Homo sapiens_hsa052110.25064917
90Pancreatic secretion_Homo sapiens_hsa049720.23649791
91Amphetamine addiction_Homo sapiens_hsa050310.20325028
92Glioma_Homo sapiens_hsa052140.18754317
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.16921210
94Purine metabolism_Homo sapiens_hsa002300.16842037
95Pentose phosphate pathway_Homo sapiens_hsa000300.15134744
96Tyrosine metabolism_Homo sapiens_hsa003500.14055055
97Endometrial cancer_Homo sapiens_hsa052130.13472444
98Melanogenesis_Homo sapiens_hsa049160.12593369
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.12301862
100Ovarian steroidogenesis_Homo sapiens_hsa049130.11742169
101Long-term potentiation_Homo sapiens_hsa047200.11183136
102Bile secretion_Homo sapiens_hsa049760.10536171
103Fat digestion and absorption_Homo sapiens_hsa049750.10143123
104Olfactory transduction_Homo sapiens_hsa047400.09722255
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.09277978
106ABC transporters_Homo sapiens_hsa020100.08763633
107Metabolic pathways_Homo sapiens_hsa011000.07318353
108Taste transduction_Homo sapiens_hsa047420.07309768
109Gap junction_Homo sapiens_hsa045400.07190684
110Salmonella infection_Homo sapiens_hsa051320.07042061
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.06393716
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.05269315
113Salivary secretion_Homo sapiens_hsa049700.05097587

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