XK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus controls the synthesis of the Kell blood group 'precursor substance' (Kx). Mutations in this gene have been associated with McLeod syndrome, an X-linked, recessive disorder characterized by abnormalities in the neuromuscular and hematopoietic systems. The encoded protein has structural characteristics of prokaryotic and eukaryotic membrane transport proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)9.23718096
2protoporphyrinogen IX biosynthetic process (GO:0006782)8.37120151
3oxygen transport (GO:0015671)7.61593233
4gas transport (GO:0015669)7.02273823
5porphyrin-containing compound biosynthetic process (GO:0006779)6.41026698
6heme biosynthetic process (GO:0006783)5.85974461
7tetrapyrrole biosynthetic process (GO:0033014)5.64099816
8neutrophil activation involved in immune response (GO:0002283)5.43870022
9thrombin receptor signaling pathway (GO:0070493)5.41240163
10erythrocyte maturation (GO:0043249)5.20197348
11regulation of platelet aggregation (GO:0090330)5.13310679
12locomotory exploration behavior (GO:0035641)4.96113311
13porphyrin-containing compound metabolic process (GO:0006778)4.87271914
14platelet formation (GO:0030220)4.59807820
15regulation of short-term neuronal synaptic plasticity (GO:0048172)4.51285962
16response to insecticide (GO:0017085)4.45527053
17definitive hemopoiesis (GO:0060216)4.44847569
18heme metabolic process (GO:0042168)4.31024106
19positive regulation of granulocyte differentiation (GO:0030854)4.20520986
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.16198366
21platelet aggregation (GO:0070527)4.08692154
22synaptic vesicle maturation (GO:0016188)4.05356492
23response to methylmercury (GO:0051597)4.04318217
24protein targeting to Golgi (GO:0000042)3.95610816
25vocalization behavior (GO:0071625)3.95423389
26synaptic vesicle exocytosis (GO:0016079)3.88472605
27regulation of platelet activation (GO:0010543)3.82167112
28iron ion import (GO:0097286)3.80062245
29erythrocyte development (GO:0048821)3.78570356
30retrograde transport, vesicle recycling within Golgi (GO:0000301)3.73911814
31regulation of synaptic vesicle exocytosis (GO:2000300)3.72520887
32granulocyte differentiation (GO:0030851)3.71377835
33protein neddylation (GO:0045116)3.66178590
34adenosine receptor signaling pathway (GO:0001973)3.60548790
35sodium ion export (GO:0071436)3.54345726
36neurotransmitter secretion (GO:0007269)3.53086495
37exploration behavior (GO:0035640)3.50343368
38regulation of glutamate receptor signaling pathway (GO:1900449)3.50129423
39positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.48371156
40cellular response to thyroid hormone stimulus (GO:0097067)3.45355257
41positive regulation of receptor recycling (GO:0001921)3.44189975
42regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.43319558
43neuronal action potential propagation (GO:0019227)3.40308996
44regulation of histone H3-K9 methylation (GO:0051570)3.39499320
45regulation of synaptic vesicle transport (GO:1902803)3.38929382
46establishment of protein localization to Golgi (GO:0072600)3.38858006
47innate immune response in mucosa (GO:0002227)3.38821968
48positive regulation of synapse maturation (GO:0090129)3.34815025
49antibacterial humoral response (GO:0019731)3.34711383
50blood coagulation, intrinsic pathway (GO:0007597)3.31344000
51regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.29392851
52hepatocyte apoptotic process (GO:0097284)3.29140088
53activation of protein kinase A activity (GO:0034199)3.29119629
54Golgi transport vesicle coating (GO:0048200)3.28618712
55COPI coating of Golgi vesicle (GO:0048205)3.28618712
56hemoglobin metabolic process (GO:0020027)3.28592701
57ionotropic glutamate receptor signaling pathway (GO:0035235)3.27657059
58G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.26688639
59cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.25978871
60negative regulation of protein localization to plasma membrane (GO:1903077)3.22372326
61neuromuscular process controlling posture (GO:0050884)3.21967281
62leukocyte migration involved in inflammatory response (GO:0002523)3.18807032
63neutrophil activation (GO:0042119)3.14851318
64regulation of response to osmotic stress (GO:0047484)3.12847185
65negative regulation of norepinephrine secretion (GO:0010700)3.11429548
66synaptic vesicle docking involved in exocytosis (GO:0016081)3.09756340
67positive regulation of mast cell activation (GO:0033005)3.09318155
68myeloid cell development (GO:0061515)3.06441898
69negative regulation of catecholamine secretion (GO:0033604)3.03510742
70regulation of integrin-mediated signaling pathway (GO:2001044)3.02597444
71negative regulation of homotypic cell-cell adhesion (GO:0034111)3.02540356
72glutamate secretion (GO:0014047)3.02494577
73antimicrobial humoral response (GO:0019730)3.00489802
74glutamate receptor signaling pathway (GO:0007215)2.99649000
75regulation of cAMP-dependent protein kinase activity (GO:2000479)2.97981823
76erythrocyte differentiation (GO:0030218)2.97297506
77neuron-neuron synaptic transmission (GO:0007270)2.95106781
78bicarbonate transport (GO:0015701)2.94116996
79DNA synthesis involved in DNA repair (GO:0000731)2.91932109
80protein localization to Golgi apparatus (GO:0034067)2.91888882
81neuron cell-cell adhesion (GO:0007158)2.91235094
82synaptic transmission, glutamatergic (GO:0035249)2.90376604
83regulation of receptor recycling (GO:0001919)2.89947387
84tetrapyrrole metabolic process (GO:0033013)2.89681462
85purine-containing compound salvage (GO:0043101)2.87385859
86purine nucleotide salvage (GO:0032261)2.86833093
87regulation of integrin activation (GO:0033623)2.86633886
88regulation of long-term neuronal synaptic plasticity (GO:0048169)2.86627827
89homotypic cell-cell adhesion (GO:0034109)2.86095767
90cerebellar Purkinje cell differentiation (GO:0021702)2.86066236
91autophagic vacuole fusion (GO:0000046)2.85544843
92negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.85538955
93long-term memory (GO:0007616)2.85308830
94regulation of Golgi to plasma membrane protein transport (GO:0042996)2.85191311
95neurotransmitter transport (GO:0006836)2.84564951
96cellular potassium ion homeostasis (GO:0030007)2.84464365
97regulation of early endosome to late endosome transport (GO:2000641)2.82383829
98gamma-aminobutyric acid signaling pathway (GO:0007214)2.81780365
99granulocyte activation (GO:0036230)2.81433056
100megakaryocyte development (GO:0035855)2.81159573
101positive regulation of membrane potential (GO:0045838)2.80349254
102positive regulation of erythrocyte differentiation (GO:0045648)2.80276625
103gamma-aminobutyric acid transport (GO:0015812)2.79596851
104positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.78922712
105positive regulation of systemic arterial blood pressure (GO:0003084)2.77872011
106negative regulation of heart contraction (GO:0045822)2.77202711
107negative regulation of adherens junction organization (GO:1903392)2.74121511
108negative regulation of focal adhesion assembly (GO:0051895)2.74121511
109negative regulation of cell junction assembly (GO:1901889)2.74121511
110positive regulation of gamma-delta T cell activation (GO:0046645)2.72233580
111mucosal immune response (GO:0002385)2.71995826
112regulation of lipoprotein metabolic process (GO:0050746)2.70328671
113regulation of inositol phosphate biosynthetic process (GO:0010919)2.69411693
114nucleoside diphosphate biosynthetic process (GO:0009133)2.68943610
115positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.68828595
116response to pheromone (GO:0019236)2.68052939
117response to histamine (GO:0034776)2.66076750
118positive regulation of neurotransmitter secretion (GO:0001956)2.65434452
119regulation of homotypic cell-cell adhesion (GO:0034110)2.64972308
120positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.64844579
121positive regulation of B cell differentiation (GO:0045579)2.64684508
122regulation of mast cell degranulation (GO:0043304)2.63755236
123succinate metabolic process (GO:0006105)2.63513464
124embryonic hemopoiesis (GO:0035162)2.63383448
125regulation of neurotransmitter levels (GO:0001505)2.63295778
126positive regulation of response to oxidative stress (GO:1902884)2.62450029
127positive regulation of cellular response to oxidative stress (GO:1900409)2.62450029
128negative regulation of erythrocyte differentiation (GO:0045647)2.61984334
129regulation of megakaryocyte differentiation (GO:0045652)2.60856022
130protein maturation by protein folding (GO:0022417)2.60773096
131negative regulation of neurotransmitter transport (GO:0051589)2.60721600
132neurotransmitter-gated ion channel clustering (GO:0072578)2.60324484
133regulation of neuronal synaptic plasticity (GO:0048168)2.60187000
134regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.59670057
135membrane depolarization during action potential (GO:0086010)2.58646908
136nuclear pore complex assembly (GO:0051292)2.56903876
137leukocyte degranulation (GO:0043299)2.56631878
138platelet degranulation (GO:0002576)2.56375745
139response to thyroid hormone (GO:0097066)2.56195576
140mesodermal cell differentiation (GO:0048333)2.55924800
141negative regulation of potassium ion transmembrane transport (GO:1901380)2.55819759
142actin filament capping (GO:0051693)2.55723126
143positive regulation of cellular amide metabolic process (GO:0034250)2.55342044
144organelle membrane fusion (GO:0090174)2.55029115
145actin filament polymerization (GO:0030041)2.54889321
146membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.54626497
147G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.54197281
148organ or tissue specific immune response (GO:0002251)2.53686398
149response to lead ion (GO:0010288)2.53680544
150regulation of clathrin-mediated endocytosis (GO:2000369)2.53558073
151triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.53507375
152regulation of calcium ion-dependent exocytosis (GO:0017158)2.53471566
153detection of calcium ion (GO:0005513)2.53253718
154pigment biosynthetic process (GO:0046148)2.52610645
155negative regulation of histone methylation (GO:0031061)2.52578090
156regulation of glucocorticoid secretion (GO:2000849)2.51705384
157cellular response to arsenic-containing substance (GO:0071243)2.51659596
158cell communication by electrical coupling (GO:0010644)2.51463105
159synaptic vesicle endocytosis (GO:0048488)2.50948153
160platelet activation (GO:0030168)2.49895408
161positive regulation of blood coagulation (GO:0030194)2.49632047
162positive regulation of hemostasis (GO:1900048)2.49632047
163negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.48369720
164nerve growth factor signaling pathway (GO:0038180)2.46739299
165microtubule depolymerization (GO:0007019)2.46272710
166regulation of ARF protein signal transduction (GO:0032012)2.45930253
167membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.42579894
168regulation of excitatory postsynaptic membrane potential (GO:0060079)2.41111540
169protein localization to synapse (GO:0035418)2.39638745
170proline transport (GO:0015824)2.39561538
171positive regulation of insulin secretion (GO:0032024)2.38802454
172positive regulation of potassium ion transmembrane transport (GO:1901381)2.38662654
173regulation of erythrocyte differentiation (GO:0045646)2.38651990
174transmission of nerve impulse (GO:0019226)2.38129024
175oxaloacetate metabolic process (GO:0006107)2.37272627
176intraspecies interaction between organisms (GO:0051703)2.36493388
177social behavior (GO:0035176)2.36493388
178cell differentiation in hindbrain (GO:0021533)2.35855081

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human6.85590206
2EZH2_22144423_ChIP-Seq_EOC_Human3.89449437
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.89152381
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.78269652
5GATA1_19941826_ChIP-Seq_K562_Human3.75687541
6GATA1_19941827_ChIP-Seq_MEL_Mouse3.48621302
7TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse3.32051342
8SCL_19346495_ChIP-Seq_HPC-7_Human3.20341319
9MYB_21317192_ChIP-Seq_ERMYB_Mouse2.86870776
10KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse2.74310186
11REST_21632747_ChIP-Seq_MESCs_Mouse2.69396881
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.39835585
13E2F7_22180533_ChIP-Seq_HELA_Human2.26801092
14REST_18959480_ChIP-ChIP_MESCs_Mouse2.19346690
15GATA2_19941826_ChIP-Seq_K562_Human2.15875499
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.09851426
17ZNF274_21170338_ChIP-Seq_K562_Hela2.02271937
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01929096
19EGR1_19374776_ChIP-ChIP_THP-1_Human1.96224500
20RUNX1_22412390_ChIP-Seq_EML_Mouse1.94550086
21GATA1_22383799_ChIP-Seq_G1ME_Mouse1.86610926
22IGF1R_20145208_ChIP-Seq_DFB_Human1.84981042
23GBX2_23144817_ChIP-Seq_PC3_Human1.84776287
24ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.82314897
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82068194
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.79858287
27ESR1_15608294_ChIP-ChIP_MCF-7_Human1.71706826
28LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.68174853
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.67183511
30GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.66713445
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66164282
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.61659815
33MYC_22102868_ChIP-Seq_BL_Human1.59939554
34ZNF263_19887448_ChIP-Seq_K562_Human1.56101939
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54854491
36* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.53320325
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53181710
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49994815
39SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44360833
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.44085760
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43499284
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.43235426
43DROSHA_22980978_ChIP-Seq_HELA_Human1.42534650
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.41821340
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39849143
46GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39061515
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38818523
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34790287
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.34344835
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.33345935
51PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28368733
52IRF8_27001747_Chip-Seq_BMDM_Mouse1.28004874
53SPI1_23547873_ChIP-Seq_NB4_Human1.27657924
54DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27416461
55MAF_26560356_Chip-Seq_TH1_Human1.26310384
56CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25556367
57STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25510569
58UTX_26944678_Chip-Seq_JUKART_Human1.24744611
59SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.24516902
60SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20092627
61SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18361513
62MYB_26560356_Chip-Seq_TH2_Human1.16780356
63MYB_26560356_Chip-Seq_TH1_Human1.16025833
64SALL4_22934838_ChIP-ChIP_CD34+_Human1.15942585
65STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.15626247
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15444698
67SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.14605522
68TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13409793
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10068038
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09496164
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09428968
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09373290
73MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08520391
74TDRD3_21172665_ChIP-Seq_MCF-7_Human1.04808250
75FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.02503364
76GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.01900841
77E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01409152
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00880109
79SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00758277
80IRF8_21731497_ChIP-ChIP_J774_Mouse1.00734089
81JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00580554
82CIITA_25753668_ChIP-Seq_RAJI_Human1.00579460
83VDR_21846776_ChIP-Seq_THP-1_Human0.99817401
84CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99598026
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99465012
86NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98682659
87SOX2_21211035_ChIP-Seq_LN229_Gbm0.98196902
88TP53_22573176_ChIP-Seq_HFKS_Human0.98126687
89IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97321203
90FOXO3_23340844_ChIP-Seq_DLD1_Human0.96467392
91GATA1_19941827_ChIP-Seq_MEL86_Mouse0.96195546
92ETS1_22383799_ChIP-Seq_G1ME_Mouse0.95444026
93ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94663904
94NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94136841
95ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.94130402
96SMAD4_21799915_ChIP-Seq_A2780_Human0.93539145
97RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92203067
98KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92186142
99PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91976127
100* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90848232
101GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90788008
102E2F4_17652178_ChIP-ChIP_JURKAT_Human0.90690814
103TFEB_21752829_ChIP-Seq_HELA_Human0.90370987
104GATA6_25053715_ChIP-Seq_YYC3_Human0.88769785
105PU_27001747_Chip-Seq_BMDM_Mouse0.88395418
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87823768
107EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87148169
108RUNX_20019798_ChIP-Seq_JUKART_Human0.86870927
109SPI1_23127762_ChIP-Seq_K562_Human0.86501474
110RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.85896551
111FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.85838653
112TCF7_22412390_ChIP-Seq_EML_Mouse0.84340538
113SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84138357
114RBPJ_22232070_ChIP-Seq_NCS_Mouse0.84011187
115CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.83563428
116RXR_22158963_ChIP-Seq_LIVER_Mouse0.83237362
117ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.81886310
118GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.80854169
119* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.80699792
120KDM2B_26808549_Chip-Seq_DND41_Human0.80262258
121GATA3_27048872_Chip-Seq_THYMUS_Human0.80138046
122IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.79229499
123E2F1_17053090_ChIP-ChIP_MCF-7_Human0.79131975
124AR_19668381_ChIP-Seq_PC3_Human0.79123012
125PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78681446
126POU3F2_20337985_ChIP-ChIP_501MEL_Human0.78598296
127GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77630460
128HOXB4_20404135_ChIP-ChIP_EML_Mouse0.77579832
129EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.77380642
130EGR1_23403033_ChIP-Seq_LIVER_Mouse0.77310916
131CTCF_21964334_ChIP-Seq_BJAB-B_Human0.77184594
132FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.76472000
133CTCF_18555785_ChIP-Seq_MESCs_Mouse0.75235582
134SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.75044953
135E2F1_21310950_ChIP-Seq_MCF-7_Human0.74282554
136CHD1_26751641_Chip-Seq_LNCaP_Human0.74278923
137ELK3_25401928_ChIP-Seq_HUVEC_Human0.73968632
138ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.73707349
139FOXM1_23109430_ChIP-Seq_U2OS_Human0.73266114
140TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.72968652
141FUS_26573619_Chip-Seq_HEK293_Human0.72848904
142TCF4_23295773_ChIP-Seq_U87_Human0.72644140
143KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.72152452
144ELF1_20517297_ChIP-Seq_JURKAT_Human0.72108815
145* SPI1_20517297_ChIP-Seq_HL60_Human0.72029767
146NCOR1_26117541_ChIP-Seq_K562_Human0.71683015
147SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.71088869
148FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.70903028
149SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.70129053
150VDR_24763502_ChIP-Seq_THP-1_Human0.70024436
151JARID2_20075857_ChIP-Seq_MESCs_Mouse0.69713201
152KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.69445609
153STAT3_23295773_ChIP-Seq_U87_Human0.69375239
154KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.69286449
155VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.69196327
156LXR_22158963_ChIP-Seq_LIVER_Mouse0.68783353
157ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.67446817
158CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.67433883
159PPARA_22158963_ChIP-Seq_LIVER_Mouse0.67416455
160* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.67344815

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level6.18130231
2MP0005464_abnormal_platelet_physiology6.06031227
3MP0003656_abnormal_erythrocyte_physiolo5.72986123
4MP0004859_abnormal_synaptic_plasticity3.99912516
5MP0008004_abnormal_stomach_pH3.29826514
6MP0003635_abnormal_synaptic_transmissio2.79221825
7MP0003303_peritoneal_inflammation2.39489628
8MP0002909_abnormal_adrenal_gland2.34736781
9MP0001968_abnormal_touch/_nociception2.31372642
10MP0009780_abnormal_chondrocyte_physiolo2.26764390
11MP0000465_gastrointestinal_hemorrhage2.24914934
12MP0009745_abnormal_behavioral_response2.21565640
13MP0003880_abnormal_central_pattern2.19503844
14MP0005083_abnormal_biliary_tract2.14042838
15MP0002736_abnormal_nociception_after2.12878212
16MP0002877_abnormal_melanocyte_morpholog2.01268099
17MP0008260_abnormal_autophagy1.99928840
18MP0004270_analgesia1.97228412
19MP0002063_abnormal_learning/memory/cond1.96190397
20MP0005451_abnormal_body_composition1.93776737
21MP0002735_abnormal_chemical_nociception1.93602392
22MP0009046_muscle_twitch1.89901118
23MP0002064_seizures1.89281631
24MP0003183_abnormal_peptide_metabolism1.87566119
25MP0004043_abnormal_pH_regulation1.83010645
26MP0004084_abnormal_cardiac_muscle1.79241443
27MP0003724_increased_susceptibility_to1.78466937
28MP0002272_abnormal_nervous_system1.77866706
29MP0002572_abnormal_emotion/affect_behav1.72550864
30MP0001501_abnormal_sleep_pattern1.66859806
31MP0008569_lethality_at_weaning1.65755453
32MP0003787_abnormal_imprinting1.64279583
33MP0002734_abnormal_mechanical_nocicepti1.62816978
34MP0001529_abnormal_vocalization1.58823058
35MP0002398_abnormal_bone_marrow1.55670403
36MP0004510_myositis1.54527060
37MP0009697_abnormal_copulation1.53993708
38MP0004130_abnormal_muscle_cell1.53372635
39MP0004036_abnormal_muscle_relaxation1.53035197
40MP0002822_catalepsy1.52805731
41MP0003879_abnormal_hair_cell1.46933236
42MP0005646_abnormal_pituitary_gland1.46833422
43MP0002733_abnormal_thermal_nociception1.46766753
44MP0002837_dystrophic_cardiac_calcinosis1.46507076
45MP0005636_abnormal_mineral_homeostasis1.46129201
46MP0002139_abnormal_hepatobiliary_system1.45961473
47MP0002067_abnormal_sensory_capabilities1.45114541
48MP0002693_abnormal_pancreas_physiology1.44259477
49MP0006036_abnormal_mitochondrial_physio1.43628410
50MP0008872_abnormal_physiological_respon1.42754211
51MP0002132_abnormal_respiratory_system1.40840126
52MP0005386_behavior/neurological_phenoty1.38866794
53MP0004924_abnormal_behavior1.38866794
54MP0004808_abnormal_hematopoietic_stem1.36026644
55MP0000343_altered_response_to1.33234223
56MP0004215_abnormal_myocardial_fiber1.32449167
57MP0003828_pulmonary_edema1.30844763
58MP0005085_abnormal_gallbladder_physiolo1.30820691
59MP0000015_abnormal_ear_pigmentation1.29918645
60MP0001944_abnormal_pancreas_morphology1.29790768
61MP0005409_darkened_coat_color1.29016463
62MP0001970_abnormal_pain_threshold1.27906887
63MP0003566_abnormal_cell_adhesion1.27379981
64MP0001486_abnormal_startle_reflex1.26318175
65MP0002722_abnormal_immune_system1.25880990
66MP0005423_abnormal_somatic_nervous1.24421452
67MP0001545_abnormal_hematopoietic_system1.23501350
68MP0005397_hematopoietic_system_phenotyp1.23501350
69MP0004145_abnormal_muscle_electrophysio1.23490131
70MP0008057_abnormal_DNA_replication1.23195897
71MP0000689_abnormal_spleen_morphology1.21222180
72MP0010155_abnormal_intestine_physiology1.20028367
73MP0003111_abnormal_nucleus_morphology1.19302892
74MP0004811_abnormal_neuron_physiology1.19270870
75MP0003866_abnormal_defecation1.14130732
76MP0005058_abnormal_lysosome_morphology1.13100581
77MP0000013_abnormal_adipose_tissue1.11432181
78MP0002078_abnormal_glucose_homeostasis1.11220986
79MP0005645_abnormal_hypothalamus_physiol1.11164304
80MP0002557_abnormal_social/conspecific_i1.10993131
81MP0004484_altered_response_of1.09977087
82MP0001188_hyperpigmentation1.08963024
83MP0009278_abnormal_bone_marrow1.08295883
84MP0004947_skin_inflammation1.08211038
85MP0001440_abnormal_grooming_behavior1.06991300
86MP0002429_abnormal_blood_cell1.05994027
87MP0003868_abnormal_feces_composition1.03661494
88MP0005666_abnormal_adipose_tissue1.03259506
89MP0003300_gastrointestinal_ulcer1.02083122
90MP0005365_abnormal_bile_salt1.01961849
91MP0001664_abnormal_digestion1.01873307
92MP0001835_abnormal_antigen_presentation1.01749389
93MP0001851_eye_inflammation1.01104112
94MP0001765_abnormal_ion_homeostasis1.00723533
95MP0005310_abnormal_salivary_gland1.00428377
96MP0008961_abnormal_basal_metabolism0.99872387
97MP0001663_abnormal_digestive_system0.99409927
98MP0005360_urolithiasis0.99034431
99MP0008877_abnormal_DNA_methylation0.98730134
100MP0005535_abnormal_body_temperature0.96904272
101MP0003329_amyloid_beta_deposits0.96809956
102MP0000490_abnormal_crypts_of0.96056852
103MP0000230_abnormal_systemic_arterial0.96020063
104MP0000703_abnormal_thymus_morphology0.95059549
105MP0004185_abnormal_adipocyte_glucose0.93720757
106MP0006276_abnormal_autonomic_nervous0.93696408
107MP0003123_paternal_imprinting0.93494713
108MP0010352_gastrointestinal_tract_polyps0.92877059
109MP0002184_abnormal_innervation0.92249034
110MP0002009_preneoplasia0.91568110
111MP0000858_altered_metastatic_potential0.91203854
112MP0003122_maternal_imprinting0.90065129
113MP0009763_increased_sensitivity_to0.89659118
114MP0001666_abnormal_nutrient_absorption0.89362299
115MP0003633_abnormal_nervous_system0.88373999
116MP0001661_extended_life_span0.88212159
117MP0009333_abnormal_splenocyte_physiolog0.87221106
118MP0004142_abnormal_muscle_tone0.86231722
119MP0005379_endocrine/exocrine_gland_phen0.86177864
120MP0002066_abnormal_motor_capabilities/c0.85856323
121MP0006054_spinal_hemorrhage0.85683911
122MP0002396_abnormal_hematopoietic_system0.85614256
123MP0004957_abnormal_blastocyst_morpholog0.84486364
124MP0010386_abnormal_urinary_bladder0.83925029
125MP0001986_abnormal_taste_sensitivity0.83885162
126MP0002229_neurodegeneration0.83316978
127MP0005501_abnormal_skin_physiology0.83072461
128MP0006072_abnormal_retinal_apoptosis0.83064875
129MP0004264_abnormal_extraembryonic_tissu0.82190804
130MP0003172_abnormal_lysosome_physiology0.81980448
131MP0008995_early_reproductive_senescence0.81760449
132MP0001544_abnormal_cardiovascular_syste0.80497944
133MP0005385_cardiovascular_system_phenoty0.80497944
134MP0004085_abnormal_heartbeat0.79542662
135MP0005187_abnormal_penis_morphology0.79041841
136MP0002972_abnormal_cardiac_muscle0.78847645
137MP0002928_abnormal_bile_duct0.78572267
138MP0003186_abnormal_redox_activity0.77668736
139MP0003763_abnormal_thymus_physiology0.77518454
140MP0008874_decreased_physiological_sensi0.76418717
141MP0003638_abnormal_response/metabolism_0.76194003
142MP0003453_abnormal_keratinocyte_physiol0.75857323
143MP0008875_abnormal_xenobiotic_pharmacok0.75704058
144MP0003436_decreased_susceptibility_to0.75568480
145MP0006138_congestive_heart_failure0.75066455
146MP0005220_abnormal_exocrine_pancreas0.74986138
147MP0005084_abnormal_gallbladder_morpholo0.74429507
148MP0009765_abnormal_xenobiotic_induced0.74313873
149MP0003191_abnormal_cellular_cholesterol0.74056147
150MP0006035_abnormal_mitochondrial_morpho0.73264860
151MP0000313_abnormal_cell_death0.73249807
152MP0001730_embryonic_growth_arrest0.72633449
153MP0003953_abnormal_hormone_level0.72089060
154MP0000716_abnormal_immune_system0.71450881
155MP0004885_abnormal_endolymph0.71322800
156MP0003283_abnormal_digestive_organ0.71269988
157MP0000609_abnormal_liver_physiology0.70516856
158MP0005000_abnormal_immune_tolerance0.70176866
159MP0002876_abnormal_thyroid_physiology0.69974594
160MP0005025_abnormal_response_to0.69707644
161MP0008775_abnormal_heart_ventricle0.69612009
162MP0002332_abnormal_exercise_endurance0.68332894
163MP0002086_abnormal_extraembryonic_tissu0.67457415
164MP0000955_abnormal_spinal_cord0.67343542
165MP0000249_abnormal_blood_vessel0.67121450
166MP0005621_abnormal_cell_physiology0.66213838
167MP0009931_abnormal_skin_appearance0.66163740
168MP0010329_abnormal_lipoprotein_level0.66040324
169MP0005448_abnormal_energy_balance0.65628556
170MP0002138_abnormal_hepatobiliary_system0.65320745
171MP0000598_abnormal_liver_morphology0.65159004
172MP0002420_abnormal_adaptive_immunity0.64260154
173MP0005174_abnormal_tail_pigmentation0.63924918
174MP0005381_digestive/alimentary_phenotyp0.63845870
175MP0001819_abnormal_immune_cell0.63172426

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)8.71140526
2Increased mean platelet volume (HP:0011877)7.41004262
3* Poikilocytosis (HP:0004447)7.37184826
4Abnormal platelet volume (HP:0011876)7.02529441
5Menorrhagia (HP:0000132)6.41652880
6Epistaxis (HP:0000421)5.48122956
7* Acanthocytosis (HP:0001927)5.33490163
8Purpura (HP:0000979)5.18007932
9Focal motor seizures (HP:0011153)4.79029405
10Gingival bleeding (HP:0000225)4.74582312
11Reticulocytosis (HP:0001923)4.72516031
12Visual hallucinations (HP:0002367)4.66989681
13Hypochromic microcytic anemia (HP:0004840)4.66989135
14Abnormal platelet function (HP:0011869)4.61454655
15Impaired platelet aggregation (HP:0003540)4.61454655
16Hyperbilirubinemia (HP:0002904)4.12889379
17Abnormal hemoglobin (HP:0011902)3.93772141
18Spontaneous hematomas (HP:0007420)3.85290435
19Cholelithiasis (HP:0001081)3.71150298
20Abnormal gallbladder morphology (HP:0012437)3.65898797
21Papilledema (HP:0001085)3.60101666
22Focal seizures (HP:0007359)3.52770416
23Epileptic encephalopathy (HP:0200134)3.36503989
24Depression (HP:0000716)3.29561101
25Atonic seizures (HP:0010819)3.25624796
26Febrile seizures (HP:0002373)3.22908537
27Abnormal social behavior (HP:0012433)3.17331182
28Impaired social interactions (HP:0000735)3.17331182
29Poor eye contact (HP:0000817)3.10836945
30Insomnia (HP:0100785)3.07514428
31Abnormality of reticulocytes (HP:0004312)3.03696947
32Anxiety (HP:0000739)3.02837849
33Hyperlipoproteinemia (HP:0010980)3.02234466
34Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.94904766
35Cholecystitis (HP:0001082)2.91479369
36Abnormal gallbladder physiology (HP:0012438)2.91479369
37Abnormal number of erythroid precursors (HP:0012131)2.89417907
38Absence seizures (HP:0002121)2.88889684
39Diaphragmatic weakness (HP:0009113)2.78342418
40Truncal ataxia (HP:0002078)2.78175000
41Cortical visual impairment (HP:0100704)2.73519277
42Generalized tonic-clonic seizures (HP:0002069)2.73439277
43Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.67604642
44Dialeptic seizures (HP:0011146)2.67325281
45Impaired smooth pursuit (HP:0007772)2.65600207
46Abnormality of cells of the erythroid lineage (HP:0012130)2.64248639
47Conjunctival telangiectasia (HP:0000524)2.62068342
48Abnormality of the gallbladder (HP:0005264)2.61290907
49Hyperthyroidism (HP:0000836)2.61255994
50Protruding tongue (HP:0010808)2.60344062
51Abnormality of iron homeostasis (HP:0011031)2.58421204
52Myokymia (HP:0002411)2.55059034
53Hyperventilation (HP:0002883)2.51045910
54Polycythemia (HP:0001901)2.50856672
55Macroorchidism (HP:0000053)2.49921660
56Hypoglycemic seizures (HP:0002173)2.48251725
57Dyschromatopsia (HP:0007641)2.46607512
58Papillary thyroid carcinoma (HP:0002895)2.45711413
59Osteomalacia (HP:0002749)2.42336990
60Postural instability (HP:0002172)2.41300118
61Hyperinsulinemic hypoglycemia (HP:0000825)2.37419345
62Status epilepticus (HP:0002133)2.36205020
63Gaze-evoked nystagmus (HP:0000640)2.34165973
64Abnormality of ocular smooth pursuit (HP:0000617)2.30229863
65Bruising susceptibility (HP:0000978)2.29921249
66Abnormality of transition element cation homeostasis (HP:0011030)2.29848187
67Tinnitus (HP:0000360)2.28506584
68Progressive cerebellar ataxia (HP:0002073)2.28159828
69Nausea (HP:0002018)2.28114244
70Truncus arteriosus (HP:0001660)2.27776578
71Epileptiform EEG discharges (HP:0011182)2.26989489
72Abnormality of the vasculature of the conjunctiva (HP:0008054)2.26516521
73Abnormality of the fingertips (HP:0001211)2.25648211
74EEG with generalized epileptiform discharges (HP:0011198)2.23534540
75Abnormality of the common coagulation pathway (HP:0010990)2.21600096
76Action tremor (HP:0002345)2.21526121
77Hypsarrhythmia (HP:0002521)2.20340153
78Agitation (HP:0000713)2.19807349
79Prolonged bleeding time (HP:0003010)2.19723238
80Ileus (HP:0002595)2.17056696
81Menstrual irregularities (HP:0000858)2.16830118
82Global brain atrophy (HP:0002283)2.15868592
83Abnormal large intestine physiology (HP:0012700)2.13272712
84Hypochromic anemia (HP:0001931)2.12478201
85Dysmetric saccades (HP:0000641)2.10808572
86Bradykinesia (HP:0002067)2.09063725
87Psychosis (HP:0000709)2.08703598
88Increased serum ferritin (HP:0003281)2.07435121
89Toxemia of pregnancy (HP:0100603)2.07094976
90Symptomatic seizures (HP:0011145)2.06850683
91Muscular hypotonia of the trunk (HP:0008936)2.06020323
92Delusions (HP:0000746)2.05975740
93Progressive inability to walk (HP:0002505)2.03031083
94Hypoglycemic coma (HP:0001325)2.01579422
95Generalized hyperpigmentation (HP:0007440)2.00870304
96Progressive microcephaly (HP:0000253)1.99539317
97Bowel incontinence (HP:0002607)1.98085467
98Abnormality of lateral ventricle (HP:0030047)1.97674972
99Broad-based gait (HP:0002136)1.97465347
100Ventricular fibrillation (HP:0001663)1.96528473
101Eczematoid dermatitis (HP:0000976)1.96184403
102Limb hypertonia (HP:0002509)1.93005896
103Pancreatic islet-cell hyperplasia (HP:0004510)1.92772742
104Pheochromocytoma (HP:0002666)1.92582505
105Chronic obstructive pulmonary disease (HP:0006510)1.92443055
106Obstructive lung disease (HP:0006536)1.92443055
107Scanning speech (HP:0002168)1.91627917
108Distal lower limb amyotrophy (HP:0008944)1.91326515
109Dysdiadochokinesis (HP:0002075)1.91076669
110Microcytic anemia (HP:0001935)1.91051888
111Decreased circulating renin level (HP:0003351)1.90809520
112Abnormal pupillary function (HP:0007686)1.90719280
113Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.90299088
114Impaired vibration sensation in the lower limbs (HP:0002166)1.89768686
115Volvulus (HP:0002580)1.89712944
116Ketoacidosis (HP:0001993)1.88208207
117Orthostatic hypotension (HP:0001278)1.87486787
118Thyroid carcinoma (HP:0002890)1.86052418
119Hyponatremia (HP:0002902)1.85966121
120Autoimmune hemolytic anemia (HP:0001890)1.85261338
121Abnormality of endocrine pancreas physiology (HP:0012093)1.84902108
122Abnormality of the pancreatic islet cells (HP:0006476)1.84902108
123Petechiae (HP:0000967)1.84159480
124Aplastic anemia (HP:0001915)1.82717040
125Hypertensive crisis (HP:0100735)1.81378552
126Insidious onset (HP:0003587)1.81337165
127Termporal pattern (HP:0011008)1.81337165
128Ankyloglossia (HP:0010296)1.81217603
129Poor suck (HP:0002033)1.80094217
130Paralysis (HP:0003470)1.78307974
131Ragged-red muscle fibers (HP:0003200)1.75442663
132Biliary tract neoplasm (HP:0100574)1.75319512
133Upper limb muscle weakness (HP:0003484)1.75101981
134Acute myeloid leukemia (HP:0004808)1.73669291
135Limb ataxia (HP:0002070)1.73653331
136Abnormality of macrophages (HP:0004311)1.73321642
137Gastrointestinal dysmotility (HP:0002579)1.73232388
138Abnormal delayed hypersensitivity skin test (HP:0002963)1.70609840
139Increased density of long bones (HP:0006392)1.69546543
140Fatigue (HP:0012378)1.69112631
141Gastrointestinal infarctions (HP:0005244)1.69012904
142Neuroendocrine neoplasm (HP:0100634)1.67163576
143Recurrent abscess formation (HP:0002722)1.66520472
144Cutaneous photosensitivity (HP:0000992)1.65296807
145Slow saccadic eye movements (HP:0000514)1.63518914
146Inflammation of the large intestine (HP:0002037)1.62962975
147Muscle fiber splitting (HP:0003555)1.61795168
148Recurrent bacterial skin infections (HP:0005406)1.61661085
149Abnormal auditory evoked potentials (HP:0006958)1.60765804
150Hepatosplenomegaly (HP:0001433)1.60684896
151Dysautonomia (HP:0002459)1.60232055
152Abnormality of sodium homeostasis (HP:0010931)1.60112568
153Hemiplegia (HP:0002301)1.59756206
154Intention tremor (HP:0002080)1.59441826
155Abnormality of binocular vision (HP:0011514)1.56964643
156Diplopia (HP:0000651)1.56964643
157Arterial thrombosis (HP:0004420)1.55979270
158Exercise-induced myalgia (HP:0003738)1.55687048
159Increased intramyocellular lipid droplets (HP:0012240)1.55588624
160Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.55487222
161Decreased activity of mitochondrial respiratory chain (HP:0008972)1.55487222
162Amyotrophic lateral sclerosis (HP:0007354)1.55244040
163Gastrointestinal inflammation (HP:0004386)1.55134602
164Neoplasm of the small intestine (HP:0100833)1.54948450
165Subaortic stenosis (HP:0001682)1.51976324
166Abnormality of the left ventricular outflow tract (HP:0011103)1.51976324
167Osteomyelitis (HP:0002754)1.51802577
168Encephalitis (HP:0002383)1.51126448
169Hepatocellular carcinoma (HP:0001402)1.50691475
170Decreased motor nerve conduction velocity (HP:0003431)1.50299802
171Seborrheic dermatitis (HP:0001051)1.50078387
172Spontaneous abortion (HP:0005268)1.49921165
173Leiomyosarcoma (HP:0100243)1.47986763

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.51823829
2BMX3.68158108
3SCYL23.57180331
4TAOK33.04053817
5MAP3K122.87307929
6PRPF4B2.82226721
7MST42.79820533
8EIF2AK12.73038002
9MAP3K42.58811181
10BMPR22.46237644
11CDK192.27420860
12MAP2K72.26975072
13CAMKK22.15555839
14MAP3K92.06975143
15PTK2B2.01056468
16STK41.99836205
17BTK1.99520398
18TEC1.98775735
19MAP2K41.96967445
20MINK11.83507384
21DAPK11.81332465
22BRSK11.77956391
23TAOK11.74081672
24TNIK1.70958155
25MAP3K21.67727193
26DAPK21.66059377
27PIK3CG1.63779342
28CAMKK11.63233033
29INSRR1.63092152
30FGR1.55178338
31KSR21.50981949
32LMTK21.47387038
33BRSK21.47121501
34HIPK21.44257250
35CDC71.39604228
36STK31.35091037
37PIM11.34317536
38ZAP701.31058679
39MYLK1.30767207
40MAP3K111.29115613
41STK241.28324624
42CCNB11.27443843
43SGK21.26765603
44MAP3K11.22657805
45PASK1.19121477
46GRK51.18269203
47CASK1.17803585
48SGK31.17409974
49GRK61.11323674
50NTRK11.04684044
51PRKD31.04021473
52BLK1.03648356
53TNK21.02110701
54CLK11.02072473
55DYRK31.01390840
56ACVR1B1.01385483
57EPHA41.00368679
58CDK50.99843620
59PLK20.99661615
60RIPK40.98544438
61HCK0.95933106
62FRK0.93917719
63SYK0.92811656
64TRPM70.90601432
65PRKCG0.90019442
66MARK30.89830159
67PDK10.86893522
68MARK10.86842671
69BRD40.86392072
70AKT30.84835960
71MAP3K60.84213857
72YES10.83939550
73MAP3K30.83488112
74CAMK10.82422620
75EEF2K0.81815433
76MAPK120.81286833
77RET0.78201761
78NEK10.75188092
79SGK4940.71806936
80SGK2230.71806936
81PDPK10.69971535
82RAF10.69778634
83SIK20.69761377
84STK160.69097056
85LYN0.68334014
86JAK20.67457231
87PRKCH0.67443746
88MAPKAPK50.67429043
89RPS6KB10.67251460
90UHMK10.66291753
91CDC42BPA0.66116992
92BRAF0.65742600
93MAPK130.64997997
94OBSCN0.64971364
95PAK10.64395276
96ILK0.63799110
97SGK10.63205054
98MATK0.61832404
99RPS6KA20.60271119
100CDK120.60145262
101MAPK110.59597426
102FES0.58111691
103STK110.56262823
104JAK30.55798909
105MAP2K10.54897677
106FLT30.54868610
107RIPK10.53320225
108RPS6KA50.52322964
109NME10.52239125
110MAP3K100.52104724
111ERBB20.50941955
112MAP3K50.50400165
113MAP2K30.48183434
114CDK11A0.48156808
115CSF1R0.47959011
116MAP3K70.47928308
117DMPK0.47344028
118TTN0.47252601
119CDK150.47133477
120PRKACG0.47056146
121RPS6KA30.46826560
122IRAK10.46614456
123IRAK30.45730410
124CDK180.45232404
125MAP2K60.45038505
126TBK10.44610161
127PRKAA10.44267047
128PRKCB0.43995638
129VRK10.43640154
130CDK140.42949014
131NTRK20.42658870
132KSR10.42513776
133CSK0.41798682
134MUSK0.41471959
135CAMK2A0.41263235
136ITK0.40410240
137TAOK20.39993669
138IRAK20.38841116
139MAPKAPK30.38132466
140PLK30.38063762
141CAMK2B0.35401536
142PNCK0.35375665
143IRAK40.33822957
144PRKG20.33752621
145PRKDC0.32496339
146WNK10.32460002
147MAP3K80.31394742
148PRKAA20.31281219
149CAMK1G0.28361116
150FGFR30.28342175
151MARK20.27663337
152DAPK30.25329862
153TTK0.25066454
154FYN0.23085556
155SIK30.22702236
156DYRK1A0.22607705

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.69809406
2Nicotine addiction_Homo sapiens_hsa050333.16525336
3Long-term potentiation_Homo sapiens_hsa047202.81982854
4Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.72983886
5Insulin secretion_Homo sapiens_hsa049112.51475804
6Synaptic vesicle cycle_Homo sapiens_hsa047212.38665732
7Circadian entrainment_Homo sapiens_hsa047132.32851558
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.30465576
9GABAergic synapse_Homo sapiens_hsa047272.24438095
10Amphetamine addiction_Homo sapiens_hsa050312.21017446
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.14760175
12Morphine addiction_Homo sapiens_hsa050322.03582218
13Glutamatergic synapse_Homo sapiens_hsa047241.95576367
14Salivary secretion_Homo sapiens_hsa049701.94602161
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.89169130
16Type II diabetes mellitus_Homo sapiens_hsa049301.84018318
17Taste transduction_Homo sapiens_hsa047421.83683138
18Dopaminergic synapse_Homo sapiens_hsa047281.80850114
19Olfactory transduction_Homo sapiens_hsa047401.80119040
20Pancreatic cancer_Homo sapiens_hsa052121.74860861
21Long-term depression_Homo sapiens_hsa047301.74505668
22Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.73265556
23Chronic myeloid leukemia_Homo sapiens_hsa052201.71221386
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.70859523
25B cell receptor signaling pathway_Homo sapiens_hsa046621.67073181
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.66948763
27Hematopoietic cell lineage_Homo sapiens_hsa046401.58761513
28Carbohydrate digestion and absorption_Homo sapiens_hsa049731.56150699
29Malaria_Homo sapiens_hsa051441.54749193
30Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.51275076
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.50932370
32Acute myeloid leukemia_Homo sapiens_hsa052211.49746228
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.45557877
34Cholinergic synapse_Homo sapiens_hsa047251.42520620
35Gastric acid secretion_Homo sapiens_hsa049711.42112714
36Renal cell carcinoma_Homo sapiens_hsa052111.40823994
37Alcoholism_Homo sapiens_hsa050341.38960131
38Thyroid cancer_Homo sapiens_hsa052161.33393319
39Endometrial cancer_Homo sapiens_hsa052131.31385641
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.31053124
41Cocaine addiction_Homo sapiens_hsa050301.30648187
42Calcium signaling pathway_Homo sapiens_hsa040201.30202906
43Renin secretion_Homo sapiens_hsa049241.27492408
44Adipocytokine signaling pathway_Homo sapiens_hsa049201.27091550
45Protein export_Homo sapiens_hsa030601.25109125
46Chemokine signaling pathway_Homo sapiens_hsa040621.25099429
47Serotonergic synapse_Homo sapiens_hsa047261.25055105
48Pancreatic secretion_Homo sapiens_hsa049721.24683428
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24401728
50Thyroid hormone synthesis_Homo sapiens_hsa049181.20634584
51ABC transporters_Homo sapiens_hsa020101.19353101
52Viral carcinogenesis_Homo sapiens_hsa052031.18645192
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.16187437
54N-Glycan biosynthesis_Homo sapiens_hsa005101.14655545
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14151105
56VEGF signaling pathway_Homo sapiens_hsa043701.13420924
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.12225109
58Renin-angiotensin system_Homo sapiens_hsa046141.09897082
59Sulfur metabolism_Homo sapiens_hsa009201.09011040
60Oxytocin signaling pathway_Homo sapiens_hsa049211.05587555
61Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05219467
62Collecting duct acid secretion_Homo sapiens_hsa049661.04185572
63Oocyte meiosis_Homo sapiens_hsa041141.03555175
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.00991264
65GnRH signaling pathway_Homo sapiens_hsa049121.00533551
66Glucagon signaling pathway_Homo sapiens_hsa049220.99394408
67Bile secretion_Homo sapiens_hsa049760.99229100
68Gap junction_Homo sapiens_hsa045400.95381968
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95054638
70Cell cycle_Homo sapiens_hsa041100.94953353
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.92713111
72cAMP signaling pathway_Homo sapiens_hsa040240.90104465
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89383504
74Cardiac muscle contraction_Homo sapiens_hsa042600.89199259
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89064785
76Starch and sucrose metabolism_Homo sapiens_hsa005000.88959454
77Estrogen signaling pathway_Homo sapiens_hsa049150.87729715
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.85417516
79Pentose phosphate pathway_Homo sapiens_hsa000300.85375883
80Mismatch repair_Homo sapiens_hsa034300.85225983
81Vitamin B6 metabolism_Homo sapiens_hsa007500.84418482
82Vibrio cholerae infection_Homo sapiens_hsa051100.84105897
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84019518
84Glioma_Homo sapiens_hsa052140.83577340
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83570765
86T cell receptor signaling pathway_Homo sapiens_hsa046600.82720431
87Osteoclast differentiation_Homo sapiens_hsa043800.81528477
88Alzheimers disease_Homo sapiens_hsa050100.80275281
89Endocytosis_Homo sapiens_hsa041440.78904797
90HIF-1 signaling pathway_Homo sapiens_hsa040660.78732100
91FoxO signaling pathway_Homo sapiens_hsa040680.76951547
92Apoptosis_Homo sapiens_hsa042100.75431449
93Non-small cell lung cancer_Homo sapiens_hsa052230.74237055
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73013295
95Arachidonic acid metabolism_Homo sapiens_hsa005900.71473312
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71088649
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70521856
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70425639
99Parkinsons disease_Homo sapiens_hsa050120.67864886
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.67505390
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66766735
102Shigellosis_Homo sapiens_hsa051310.66174824
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64745105
104Nitrogen metabolism_Homo sapiens_hsa009100.63038320
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62754375
106Insulin signaling pathway_Homo sapiens_hsa049100.62744454
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62061385
108Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61831962
109Hepatitis B_Homo sapiens_hsa051610.61584603
110Systemic lupus erythematosus_Homo sapiens_hsa053220.61494969
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59519737
112Glycerolipid metabolism_Homo sapiens_hsa005610.57975074
113Small cell lung cancer_Homo sapiens_hsa052220.57555701
114Bladder cancer_Homo sapiens_hsa052190.57483863
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56768517
116Inositol phosphate metabolism_Homo sapiens_hsa005620.53048739
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52928116
118mTOR signaling pathway_Homo sapiens_hsa041500.52781154
119Oxidative phosphorylation_Homo sapiens_hsa001900.51989572
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.51378714
121Type I diabetes mellitus_Homo sapiens_hsa049400.51238308
122Platelet activation_Homo sapiens_hsa046110.50146370
123Fatty acid biosynthesis_Homo sapiens_hsa000610.49861387
124Prolactin signaling pathway_Homo sapiens_hsa049170.49712125
125Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48537192
126Hepatitis C_Homo sapiens_hsa051600.44974512
127Leishmaniasis_Homo sapiens_hsa051400.44662819
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43616409
129NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43534563
130African trypanosomiasis_Homo sapiens_hsa051430.42621080
131Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41983567
132Choline metabolism in cancer_Homo sapiens_hsa052310.41603449
133Fatty acid elongation_Homo sapiens_hsa000620.41533837
134Prostate cancer_Homo sapiens_hsa052150.40904084
135Circadian rhythm_Homo sapiens_hsa047100.39371240
136ErbB signaling pathway_Homo sapiens_hsa040120.39343690
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.38674200
138Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.34868348
139AMPK signaling pathway_Homo sapiens_hsa041520.34755696
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.34397317
141Fat digestion and absorption_Homo sapiens_hsa049750.34038061
142Pyruvate metabolism_Homo sapiens_hsa006200.34035144
143Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33077601
144Insulin resistance_Homo sapiens_hsa049310.32887904
145Regulation of autophagy_Homo sapiens_hsa041400.32395530
146Galactose metabolism_Homo sapiens_hsa000520.31473730
147Dorso-ventral axis formation_Homo sapiens_hsa043200.31383869
148Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29962421
149Huntingtons disease_Homo sapiens_hsa050160.29746171
150Cysteine and methionine metabolism_Homo sapiens_hsa002700.27325256

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