XKR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: XKRX (MIM 300684) and XKR3 are homologs of the Kell blood group precursor XK (MIM 314850), which is a putative membrane transporter and a component of the XK/Kell complex of the Kell blood group system (Calenda et al., 2006 [PubMed 16431037]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.39343452
2DNA topological change (GO:0006265)5.88357354
3nuclear pore organization (GO:0006999)5.45263810
4DNA replication checkpoint (GO:0000076)5.04596475
5regulation of translational fidelity (GO:0006450)4.88202636
6gas transport (GO:0015669)4.85535997
7pore complex assembly (GO:0046931)4.84538551
8protoporphyrinogen IX metabolic process (GO:0046501)4.78190411
9resolution of meiotic recombination intermediates (GO:0000712)4.72901703
10regulation of histone H3-K4 methylation (GO:0051569)4.57045465
11oxygen transport (GO:0015671)4.53772439
12synapsis (GO:0007129)4.51557362
13DNA replication initiation (GO:0006270)4.28551649
14erythrocyte maturation (GO:0043249)4.27641889
15diterpenoid biosynthetic process (GO:0016102)4.24854186
16mitotic nuclear envelope disassembly (GO:0007077)4.17364362
17definitive hemopoiesis (GO:0060216)4.17272557
18regulation of histone H3-K27 methylation (GO:0061085)4.14967418
19protoporphyrinogen IX biosynthetic process (GO:0006782)4.14888375
20detection of chemical stimulus involved in sensory perception of smell (GO:0050911)4.13422558
21sensory perception of smell (GO:0007608)4.07454967
22terpenoid biosynthetic process (GO:0016114)3.88115763
23membrane disassembly (GO:0030397)3.86045823
24nuclear envelope disassembly (GO:0051081)3.86045823
25erythrocyte development (GO:0048821)3.82289981
26DNA strand elongation involved in DNA replication (GO:0006271)3.75613055
27meiotic chromosome segregation (GO:0045132)3.75517705
28telomere maintenance via semi-conservative replication (GO:0032201)3.73442122
29granulocyte differentiation (GO:0030851)3.71066823
30kinetochore organization (GO:0051383)3.68450945
31regulation of RNA export from nucleus (GO:0046831)3.65198200
32DNA strand elongation (GO:0022616)3.61905297
33DNA unwinding involved in DNA replication (GO:0006268)3.52491680
34tRNA aminoacylation for protein translation (GO:0006418)3.51388684
35homocysteine metabolic process (GO:0050667)3.50657630
36mitotic sister chromatid segregation (GO:0000070)3.50375345
37negative regulation of erythrocyte differentiation (GO:0045647)3.49356357
38purine nucleobase biosynthetic process (GO:0009113)3.46139869
39telomere maintenance via recombination (GO:0000722)3.42757692
40regulation of memory T cell differentiation (GO:0043380)3.41718580
41sister chromatid segregation (GO:0000819)3.40001561
42negative regulation of histone methylation (GO:0031061)3.39524771
43amino acid activation (GO:0043038)3.39504594
44tRNA aminoacylation (GO:0043039)3.39504594
45negative regulation of fatty acid biosynthetic process (GO:0045717)3.36278022
46kinetochore assembly (GO:0051382)3.35433262
47formation of translation preinitiation complex (GO:0001731)3.30485516
48centriole replication (GO:0007099)3.28474167
49mitotic recombination (GO:0006312)3.25976391
50proteasome assembly (GO:0043248)3.25007083
51folic acid-containing compound biosynthetic process (GO:0009396)3.22720646
52microtubule depolymerization (GO:0007019)3.19462503
53mitotic chromosome condensation (GO:0007076)3.18807455
54tetrahydrofolate metabolic process (GO:0046653)3.17367876
55chromosome segregation (GO:0007059)3.16420072
56replication fork processing (GO:0031297)3.16046641
57nucleobase biosynthetic process (GO:0046112)3.12967581
58regulation of histone methylation (GO:0031060)3.12809782
59rRNA methylation (GO:0031167)3.10985700
60regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.09929854
61positive regulation of histone H3-K4 methylation (GO:0051571)3.05511355
62vitamin A metabolic process (GO:0006776)3.05310818
63negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.04511657
64regulation of centriole replication (GO:0046599)3.03305439
65negative regulation of protein acetylation (GO:1901984)3.02394541
66creatine metabolic process (GO:0006600)3.02177093
67protein localization to kinetochore (GO:0034501)3.01945152
68oxidative phosphorylation (GO:0006119)2.99617217
69IMP biosynthetic process (GO:0006188)2.96767787
70response to vitamin A (GO:0033189)2.96576324
71regulation of translational elongation (GO:0006448)2.95306219
72iron ion import (GO:0097286)2.94098365
73poly(A)+ mRNA export from nucleus (GO:0016973)2.91894678
74protein export from nucleus (GO:0006611)2.91042263
75folic acid metabolic process (GO:0046655)2.89170599
76regulation of nucleobase-containing compound transport (GO:0032239)2.86836883
77positive regulation of B cell differentiation (GO:0045579)2.86671964
78regulation of mitotic spindle organization (GO:0060236)2.86314751
79rRNA modification (GO:0000154)2.85182410
80mismatch repair (GO:0006298)2.84331825
81positive regulation of gamma-delta T cell activation (GO:0046645)2.84235550
82mucosal-associated lymphoid tissue development (GO:0048537)2.83229723
83Peyers patch development (GO:0048541)2.83229723
84regulation of histone H3-K9 methylation (GO:0051570)2.78807354
85positive regulation of histone methylation (GO:0031062)2.77414640
86myeloid cell development (GO:0061515)2.76831138
87regulation of double-strand break repair via homologous recombination (GO:0010569)2.75948369
88heme biosynthetic process (GO:0006783)2.75110376
89nuclear envelope organization (GO:0006998)2.74847928
90centriole assembly (GO:0098534)2.71278825
91mitochondrial DNA metabolic process (GO:0032042)2.70832473
92porphyrin-containing compound biosynthetic process (GO:0006779)2.70536069
93protein localization to chromosome, centromeric region (GO:0071459)2.70367455
94DNA damage induced protein phosphorylation (GO:0006975)2.69670176
95regulation of gene expression by genetic imprinting (GO:0006349)2.67881135
96oxaloacetate metabolic process (GO:0006107)2.67037182
97JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.65510546
98misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.65167894
99DNA conformation change (GO:0071103)2.65146069
100nucleotide-excision repair, DNA gap filling (GO:0006297)2.65121245

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.00140645
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.46098867
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.41480069
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.29367314
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.06916890
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.01353197
7* NCOR1_26117541_ChIP-Seq_K562_Human2.99251267
8GATA1_19941826_ChIP-Seq_K562_Human2.88446004
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.60946243
10GATA1_22025678_ChIP-Seq_K562_Human2.60170231
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54955540
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.49741731
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.33154705
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.26130465
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.22430299
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.20882797
17SCL_19346495_ChIP-Seq_HPC-7_Human2.18303546
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.17770751
19SPI1_23127762_ChIP-Seq_K562_Human2.09739885
20GATA2_19941826_ChIP-Seq_K562_Human2.03992781
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.00058833
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.94014422
23DCP1A_22483619_ChIP-Seq_HELA_Human1.92105442
24MYC_19079543_ChIP-ChIP_MESCs_Mouse1.91868478
25XRN2_22483619_ChIP-Seq_HELA_Human1.90045296
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.90040205
27HOXB4_20404135_ChIP-ChIP_EML_Mouse1.89049301
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.86975350
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78860065
30PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.76994027
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74544371
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.73310260
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.69559190
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.69109748
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63550656
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60946504
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.59508703
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.59233905
39FOXP3_21729870_ChIP-Seq_TREG_Human1.56755199
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56512956
41MYC_22102868_ChIP-Seq_BL_Human1.54587578
42KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.54570570
43VDR_23849224_ChIP-Seq_CD4+_Human1.52606028
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.52262919
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51667938
46KDM5A_27292631_Chip-Seq_BREAST_Human1.51556271
47TTF2_22483619_ChIP-Seq_HELA_Human1.48122079
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48057870
49ELK1_19687146_ChIP-ChIP_HELA_Human1.46177998
50SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41036164
51CIITA_25753668_ChIP-Seq_RAJI_Human1.40922159
52GABP_19822575_ChIP-Seq_HepG2_Human1.39718647
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36326341
54E2F1_18555785_ChIP-Seq_MESCs_Mouse1.36292925
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33847729
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33218820
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31985078
58SPI1_23547873_ChIP-Seq_NB4_Human1.31679038
59TFEB_21752829_ChIP-Seq_HELA_Human1.30534580
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28486711
61BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.27782802
62GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25919671
63MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.19580716
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19449511
65CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.18147761
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17461379
67ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15986316
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15794940
69STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13888105
70MAF_26560356_Chip-Seq_TH1_Human1.13361642
71CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.13139643
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12443086
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11995394
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11723196
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11020426
76MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10449556
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07745095
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07391901
79CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06475385
80ZNF263_19887448_ChIP-Seq_K562_Human1.06407044
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06185784
82AR_21909140_ChIP-Seq_LNCAP_Human1.05094561
83MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01938709
84MYB_26560356_Chip-Seq_TH1_Human1.01757712
85KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01703387
86ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99361146
87YY1_21170310_ChIP-Seq_MESCs_Mouse0.96872677
88NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95669641
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95366820
90HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94947562
91GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93170497
92TBX5_21415370_ChIP-Seq_HL-1_Mouse0.92728786
93GATA6_21074721_ChIP-Seq_CACO-2_Human0.92621282
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92113435
95ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91810975
96GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91202910
97WT1_19549856_ChIP-ChIP_CCG9911_Human0.91082383
98MYB_26560356_Chip-Seq_TH2_Human0.90842808
99PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.89322793
100STAT4_19710469_ChIP-ChIP_TH1__Mouse0.87981499

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level4.87149287
2MP0008995_early_reproductive_senescence4.31319125
3MP0008057_abnormal_DNA_replication3.69170775
4MP0008058_abnormal_DNA_repair3.49927097
5MP0005451_abnormal_body_composition3.48728249
6MP0010094_abnormal_chromosome_stability3.43803191
7MP0003111_abnormal_nucleus_morphology3.40669060
8MP0004957_abnormal_blastocyst_morpholog3.22290129
9MP0001545_abnormal_hematopoietic_system3.17902598
10MP0005397_hematopoietic_system_phenotyp3.17902598
11MP0003656_abnormal_erythrocyte_physiolo3.05517399
12MP0005083_abnormal_biliary_tract3.02877350
13MP0003786_premature_aging2.94060351
14MP0002132_abnormal_respiratory_system2.84249291
15MP0000678_abnormal_parathyroid_gland2.66972101
16MP0009278_abnormal_bone_marrow2.51357719
17MP0009697_abnormal_copulation2.50695977
18MP0002396_abnormal_hematopoietic_system2.24462578
19MP0005464_abnormal_platelet_physiology2.19075896
20MP0003693_abnormal_embryo_hatching2.18771229
21MP0008932_abnormal_embryonic_tissue2.02521425
22MP0006036_abnormal_mitochondrial_physio1.98710493
23MP0003077_abnormal_cell_cycle1.94981892
24MP0008007_abnormal_cellular_replicative1.93331559
25MP0006035_abnormal_mitochondrial_morpho1.89239517
26MP0003806_abnormal_nucleotide_metabolis1.52895611
27MP0003718_maternal_effect1.49336567
28MP0000313_abnormal_cell_death1.40550106
29MP0010307_abnormal_tumor_latency1.32176172
30MP0001929_abnormal_gametogenesis1.30878740
31MP0002398_abnormal_bone_marrow1.29125546
32MP0005410_abnormal_fertilization1.27879382
33MP0000350_abnormal_cell_proliferation1.27002182
34MP0001697_abnormal_embryo_size1.26896500
35MP0000372_irregular_coat_pigmentation1.23084318
36MP0005636_abnormal_mineral_homeostasis1.18500634
37MP0002722_abnormal_immune_system1.18301312
38MP0002210_abnormal_sex_determination1.17941035
39MP0001730_embryonic_growth_arrest1.16835384
40MP0002019_abnormal_tumor_incidence1.15674433
41MP0000703_abnormal_thymus_morphology1.15646846
42MP0001661_extended_life_span1.14379182
43MP0003646_muscle_fatigue1.14373359
44MP0004808_abnormal_hematopoietic_stem1.12888243
45MP0001873_stomach_inflammation1.10203750
46MP0002080_prenatal_lethality1.08089802
47MP0005408_hypopigmentation1.07157163
48MP0009333_abnormal_splenocyte_physiolog1.07129534
49MP0000358_abnormal_cell_content/1.06742242
50MP0001672_abnormal_embryogenesis/_devel1.04962632
51MP0005380_embryogenesis_phenotype1.04962632
52MP0003186_abnormal_redox_activity1.03359358
53MP0003984_embryonic_growth_retardation1.01507934
54MP0000689_abnormal_spleen_morphology1.01465635
55MP0005646_abnormal_pituitary_gland1.00826631
56MP0002877_abnormal_melanocyte_morpholog0.99783314
57MP0003221_abnormal_cardiomyocyte_apopto0.99488251
58MP0001764_abnormal_homeostasis0.99332733
59MP0002088_abnormal_embryonic_growth/wei0.97687052
60MP0004233_abnormal_muscle_weight0.96921282
61MP0002429_abnormal_blood_cell0.96505294
62MP0004145_abnormal_muscle_electrophysio0.93433603
63MP0008775_abnormal_heart_ventricle0.92784997
64MP0002086_abnormal_extraembryonic_tissu0.92151452
65MP0003950_abnormal_plasma_membrane0.88997780
66MP0000609_abnormal_liver_physiology0.87440606
67MP0003698_abnormal_male_reproductive0.86222684
68MP0001145_abnormal_male_reproductive0.84972217
69MP0003436_decreased_susceptibility_to0.83188334
70MP0001727_abnormal_embryo_implantation0.82990412
71MP0000653_abnormal_sex_gland0.81698935
72MP0003959_abnormal_lean_body0.80950188
73MP0004947_skin_inflammation0.80911543
74MP0002095_abnormal_skin_pigmentation0.78920229
75MP0002419_abnormal_innate_immunity0.75596035
76MP0000598_abnormal_liver_morphology0.69025567
77MP0009931_abnormal_skin_appearance0.68381586
78MP0000716_abnormal_immune_system0.67751905
79MP0005332_abnormal_amino_acid0.66835961
80MP0000343_altered_response_to0.66341567
81MP0005535_abnormal_body_temperature0.66203087
82MP0008770_decreased_survivor_rate0.64923199
83MP0001819_abnormal_immune_cell0.64725156
84MP0002420_abnormal_adaptive_immunity0.64603022
85MP0003699_abnormal_female_reproductive0.64035871
86MP0006292_abnormal_olfactory_placode0.62946158
87MP0002723_abnormal_immune_serum0.61170348
88MP0009115_abnormal_fat_cell0.61130828
89MP0000015_abnormal_ear_pigmentation0.61003228
90MP0004019_abnormal_vitamin_homeostasis0.60973925
91MP0008872_abnormal_physiological_respon0.60747619
92MP0001529_abnormal_vocalization0.60010303
93MP0002269_muscular_atrophy0.59774894
94MP0000681_abnormal_thyroid_gland0.59527561
95MP0004134_abnormal_chest_morphology0.59005870
96MP0001881_abnormal_mammary_gland0.58146579
97MP0009765_abnormal_xenobiotic_induced0.58042967
98MP0005000_abnormal_immune_tolerance0.57783359
99MP0004883_abnormal_blood_vessel0.57635235
100MP0002139_abnormal_hepatobiliary_system0.56335010

Predicted human phenotypes

RankGene SetZ-score
1Truncus arteriosus (HP:0001660)6.11081548
2Hyperthyroidism (HP:0000836)5.87887589
3Abnormal gallbladder physiology (HP:0012438)5.87397064
4Cholecystitis (HP:0001082)5.87397064
5Reticulocytosis (HP:0001923)4.92024458
6Abnormality of the heme biosynthetic pathway (HP:0010472)4.89152911
7Polycythemia (HP:0001901)4.68617102
8Hypertensive crisis (HP:0100735)4.48463550
9Chromsome breakage (HP:0040012)4.14274120
10Seborrheic dermatitis (HP:0001051)4.13231019
11Abnormality of reticulocytes (HP:0004312)4.12136223
12Chromosomal breakage induced by crosslinking agents (HP:0003221)4.10510844
13Bowel incontinence (HP:0002607)3.99137353
14Abnormal large intestine physiology (HP:0012700)3.95460200
15Poikilocytosis (HP:0004447)3.66334565
16Ankyloglossia (HP:0010296)3.58814942
17Homocystinuria (HP:0002156)3.38215500
18Abnormality of homocysteine metabolism (HP:0010919)3.38215500
19Abnormal hemoglobin (HP:0011902)3.36935725
20Birth length less than 3rd percentile (HP:0003561)3.36854494
21Ileus (HP:0002595)3.36760412
22Abnormality of the tricuspid valve (HP:0001702)3.33200194
23Hypoparathyroidism (HP:0000829)3.31667307
24Acanthocytosis (HP:0001927)3.31517275
25Increased serum pyruvate (HP:0003542)3.28222384
26Abnormality of glycolysis (HP:0004366)3.17138455
27Acute myeloid leukemia (HP:0004808)3.08018208
28Atelectasis (HP:0100750)3.06617134
29Abnormality of the preputium (HP:0100587)3.03717844
30Chronic obstructive pulmonary disease (HP:0006510)3.00060012
31Obstructive lung disease (HP:0006536)3.00060012
32Acute encephalopathy (HP:0006846)2.94332101
33Myelodysplasia (HP:0002863)2.93540275
34Acute necrotizing encephalopathy (HP:0006965)2.89645841
35Aplasia/Hypoplasia of the earlobes (HP:0009906)2.87071270
36Cholelithiasis (HP:0001081)2.86976631
37Abnormal mitochondria in muscle tissue (HP:0008316)2.84257010
38Pallor (HP:0000980)2.82683162
39Aplasia/Hypoplasia of the thymus (HP:0010515)2.81102920
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.78634749
41Abnormality of cochlea (HP:0000375)2.75203537
42Upper limb muscle weakness (HP:0003484)2.74007788
43Abnormality of chromosome stability (HP:0003220)2.73807299
44Small intestinal stenosis (HP:0012848)2.65020161
45Duodenal stenosis (HP:0100867)2.65020161
46Short middle phalanx of the 5th finger (HP:0004220)2.60499472
47Abnormality of DNA repair (HP:0003254)2.57848699
48Cortical dysplasia (HP:0002539)2.54658066
49Duplicated collecting system (HP:0000081)2.53094055
50Breech presentation (HP:0001623)2.49793232
51Abnormal gallbladder morphology (HP:0012437)2.48888382
52Prolonged bleeding time (HP:0003010)2.46505963
53Reticulocytopenia (HP:0001896)2.43483282
54Progressive macrocephaly (HP:0004481)2.41605364
55Abnormality of oral frenula (HP:0000190)2.40024526
56Abnormal platelet function (HP:0011869)2.38707336
57Impaired platelet aggregation (HP:0003540)2.38707336
58Abnormality of the gallbladder (HP:0005264)2.23266841
59Overlapping toe (HP:0001845)2.22644053
60Abnormally folded helix (HP:0008544)2.18816971
61Tinnitus (HP:0000360)2.18099814
62Patellar dislocation (HP:0002999)2.17922441
63Meckel diverticulum (HP:0002245)2.17506401
64Abnormality of the renal collecting system (HP:0004742)2.12154224
65Hyperbilirubinemia (HP:0002904)2.09306417
66Abnormality of the carotid arteries (HP:0005344)2.01353525
67Abnormality of the ileum (HP:0001549)2.00801729
68Abnormality of the thymus (HP:0000777)1.99040578
69Petechiae (HP:0000967)1.95734739
70Increased nuchal translucency (HP:0010880)1.92883839
71Increased CSF lactate (HP:0002490)1.92783985
72Morphological abnormality of the inner ear (HP:0011390)1.92068640
73Premature ovarian failure (HP:0008209)1.91904803
74Abnormality of the duodenum (HP:0002246)1.90526040
75Abnormality of sulfur amino acid metabolism (HP:0004339)1.89123903
76Aplastic anemia (HP:0001915)1.88296567
77Flat cornea (HP:0007720)1.87811823
78Venous insufficiency (HP:0005293)1.86758839
79Cerebral edema (HP:0002181)1.86295563
80Orthostatic hypotension (HP:0001278)1.85695539
81Bone marrow hypocellularity (HP:0005528)1.85064131
82Sandal gap (HP:0001852)1.83771515
83Septate vagina (HP:0001153)1.82725136
84Cheekbone underdevelopment (HP:0010669)1.79293022
85Nonimmune hydrops fetalis (HP:0001790)1.77605274
86Overfolded helix (HP:0000396)1.77585496
87Fatigue (HP:0012378)1.77524632
88Ragged-red muscle fibers (HP:0003200)1.76685827
89Gastrointestinal dysmotility (HP:0002579)1.76165670
90Mitochondrial inheritance (HP:0001427)1.74056958
91Delusions (HP:0000746)1.73403935
92Cafe-au-lait spot (HP:0000957)1.70397392
93Respiratory difficulties (HP:0002880)1.69661293
94Cortical visual impairment (HP:0100704)1.67911482
95Increased hepatocellular lipid droplets (HP:0006565)1.66728872
96Disproportionate tall stature (HP:0001519)1.66198985
97Arteriovenous malformation (HP:0100026)1.66187419
98Abnormality of pyrimidine metabolism (HP:0004353)1.65299834
99Attention deficit hyperactivity disorder (HP:0007018)1.63751224
100Paralysis (HP:0003470)1.63743050

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK46.36992951
2EIF2AK14.24442655
3CLK13.51772015
4KSR23.33515000
5TTK3.17449497
6PLK43.11359799
7BMPR22.88643833
8BRSK22.51160299
9MAP3K22.42689209
10CDC72.34795998
11NTRK32.29468954
12RAF12.25472403
13CCNB12.16402162
14PDK22.12229825
15NME11.66843246
16WEE11.66726066
17KSR11.64051888
18NEK21.60418924
19TEC1.55564562
20MST41.53623109
21SRPK11.53272176
22BUB11.45198644
23NEK11.43078530
24TAOK31.40567316
25BMX1.37055313
26MAP3K81.33503445
27JAK21.23650388
28PBK1.19170132
29CHEK21.17477535
30PIK3CG1.14261656
31IRAK31.13222981
32EEF2K1.12919504
33BTK1.08902195
34YES11.04827512
35STK41.03700625
36MARK31.01006642
37ATR0.98602298
38BRSK10.97332077
39TSSK60.94056137
40TYK20.92330109
41SCYL20.89541466
42ALK0.89298498
43IRAK40.87645336
44WNK10.83198546
45PLK30.81982393
46JAK30.80255388
47MAP2K30.79372704
48CHEK10.76502190
49BLK0.75509429
50PAK10.73048583
51WNK40.73004897
52MAP3K60.73003154
53TRPM70.68938888
54RET0.67148903
55CDK10.67138982
56ATM0.66943483
57STK30.66495286
58MAP2K10.66481111
59EIF2AK30.66335754
60MAP3K10.65750849
61PTK60.65128247
62MAP3K40.64656191
63RPS6KB20.59728344
64CDK20.57255623
65PLK10.57196079
66HCK0.55986625
67MAPK120.55762838
68PLK20.55374388
69IRAK10.53201101
70CAMK1D0.52751990
71SYK0.51948845
72SIK20.49365991
73NME20.48697605
74PIM10.48489594
75LRRK20.48180564
76CSNK2A20.46324351
77MAPK110.43846463
78MAPK100.39633420
79MATK0.38733968
80ILK0.38026360
81STK100.37836292
82RPS6KA40.37562818
83CDK120.36325347
84ICK0.36265221
85MKNK10.34349339
86CSNK2A10.34200532
87CDK40.33504046
88SGK10.33356978
89BRD40.33052648
90PRKAA10.32695395
91MAPK130.29733398
92NUAK10.29396964
93RPS6KA50.29377861
94CSNK1E0.29110085
95GSK3B0.28883358
96LYN0.28727333
97MAPK140.28061151
98MAP2K60.27966693
99MAPK30.27580082
100AURKB0.27184457

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009704.10010582
2Mismatch repair_Homo sapiens_hsa034304.03765900
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.94907893
4One carbon pool by folate_Homo sapiens_hsa006703.57569186
5DNA replication_Homo sapiens_hsa030303.56428362
6Homologous recombination_Homo sapiens_hsa034403.51584279
7Fanconi anemia pathway_Homo sapiens_hsa034603.00492746
8Steroid biosynthesis_Homo sapiens_hsa001002.69710148
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.39220299
10Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.28788928
11Olfactory transduction_Homo sapiens_hsa047402.24239063
12Spliceosome_Homo sapiens_hsa030402.10640655
13RNA transport_Homo sapiens_hsa030132.09600563
14Nucleotide excision repair_Homo sapiens_hsa034202.05132140
15Cell cycle_Homo sapiens_hsa041101.87271468
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.58079678
17Basal transcription factors_Homo sapiens_hsa030221.57448327
18Acute myeloid leukemia_Homo sapiens_hsa052211.57238221
19Base excision repair_Homo sapiens_hsa034101.47062870
20RNA polymerase_Homo sapiens_hsa030201.46773800
21Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.37198198
22Oxidative phosphorylation_Homo sapiens_hsa001901.36418243
23Pyruvate metabolism_Homo sapiens_hsa006201.34651741
24Parkinsons disease_Homo sapiens_hsa050121.32484776
25Ribosome_Homo sapiens_hsa030101.31964507
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30216659
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.18720185
28Carbon metabolism_Homo sapiens_hsa012001.15117328
29Biosynthesis of amino acids_Homo sapiens_hsa012301.12814237
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.11253144
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08876269
32mRNA surveillance pathway_Homo sapiens_hsa030151.08799400
33Butanoate metabolism_Homo sapiens_hsa006501.08747538
34Fructose and mannose metabolism_Homo sapiens_hsa000511.06893801
35Chronic myeloid leukemia_Homo sapiens_hsa052201.03060914
36RNA degradation_Homo sapiens_hsa030180.99952912
37Non-homologous end-joining_Homo sapiens_hsa034500.99165291
38Other glycan degradation_Homo sapiens_hsa005110.96727409
39Type II diabetes mellitus_Homo sapiens_hsa049300.96513055
40Huntingtons disease_Homo sapiens_hsa050160.96301633
41Pyrimidine metabolism_Homo sapiens_hsa002400.93527767
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.89285772
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88996807
44Proteasome_Homo sapiens_hsa030500.88064414
45Oocyte meiosis_Homo sapiens_hsa041140.86258916
46Pentose phosphate pathway_Homo sapiens_hsa000300.83337850
47HIF-1 signaling pathway_Homo sapiens_hsa040660.82729331
48Non-small cell lung cancer_Homo sapiens_hsa052230.81887196
49Purine metabolism_Homo sapiens_hsa002300.79150318
50Viral carcinogenesis_Homo sapiens_hsa052030.75598553
51Renal cell carcinoma_Homo sapiens_hsa052110.74589709
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73890694
53B cell receptor signaling pathway_Homo sapiens_hsa046620.73529469
54VEGF signaling pathway_Homo sapiens_hsa043700.68351299
55Pancreatic cancer_Homo sapiens_hsa052120.67863695
56Hepatitis B_Homo sapiens_hsa051610.65522862
57Shigellosis_Homo sapiens_hsa051310.65141700
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60179874
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60053087
60Fatty acid metabolism_Homo sapiens_hsa012120.59484095
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58422261
62ErbB signaling pathway_Homo sapiens_hsa040120.57910440
63Prolactin signaling pathway_Homo sapiens_hsa049170.57686449
64Arginine biosynthesis_Homo sapiens_hsa002200.56144839
65Alzheimers disease_Homo sapiens_hsa050100.55787087
66Thyroid cancer_Homo sapiens_hsa052160.53249525
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51998164
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51992810
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.51030630
70Epstein-Barr virus infection_Homo sapiens_hsa051690.49594428
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49382304
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49355086
73Measles_Homo sapiens_hsa051620.48764645
74Leishmaniasis_Homo sapiens_hsa051400.48210190
75mTOR signaling pathway_Homo sapiens_hsa041500.47611457
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47247262
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46326381
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45279646
79Propanoate metabolism_Homo sapiens_hsa006400.44081622
80Apoptosis_Homo sapiens_hsa042100.44059922
81Glutathione metabolism_Homo sapiens_hsa004800.43480039
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.41955587
83Fatty acid biosynthesis_Homo sapiens_hsa000610.39743302
84Metabolic pathways_Homo sapiens_hsa011000.36577771
85p53 signaling pathway_Homo sapiens_hsa041150.36201638
86Platelet activation_Homo sapiens_hsa046110.33387603
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33129625
88Insulin signaling pathway_Homo sapiens_hsa049100.32342953
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.30685231
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29262553
91Selenocompound metabolism_Homo sapiens_hsa004500.28409000
92Fatty acid elongation_Homo sapiens_hsa000620.28086067
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.28031381
94Herpes simplex infection_Homo sapiens_hsa051680.27952435
95N-Glycan biosynthesis_Homo sapiens_hsa005100.27555277
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24823372
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23773854
98Glioma_Homo sapiens_hsa052140.22974512
99Osteoclast differentiation_Homo sapiens_hsa043800.22921564
100Influenza A_Homo sapiens_hsa051640.21364844

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