XKR4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.96853903
2behavioral response to nicotine (GO:0035095)5.88604488
3vocalization behavior (GO:0071625)5.76472523
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.51242772
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.30960980
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.24556999
7locomotory exploration behavior (GO:0035641)5.22726020
8protein localization to synapse (GO:0035418)5.19191603
9ionotropic glutamate receptor signaling pathway (GO:0035235)5.00197868
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.95310696
11synaptic vesicle exocytosis (GO:0016079)4.91543226
12regulation of glutamate receptor signaling pathway (GO:1900449)4.88197772
13synaptic vesicle maturation (GO:0016188)4.84304460
14exploration behavior (GO:0035640)4.71450502
15glutamate receptor signaling pathway (GO:0007215)4.62621325
16neuron recognition (GO:0008038)4.61901121
17layer formation in cerebral cortex (GO:0021819)4.61455279
18glutamate secretion (GO:0014047)4.59856323
19dendritic spine morphogenesis (GO:0060997)4.41307882
20presynaptic membrane assembly (GO:0097105)4.31362980
21regulation of synaptic vesicle exocytosis (GO:2000300)4.31276436
22axonal fasciculation (GO:0007413)4.29698170
23synaptic transmission, glutamatergic (GO:0035249)4.29399251
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.24645052
25regulation of long-term neuronal synaptic plasticity (GO:0048169)4.24510445
26proline transport (GO:0015824)4.17309584
27postsynaptic membrane organization (GO:0001941)4.16953517
28neuron-neuron synaptic transmission (GO:0007270)4.07196276
29pyrimidine nucleobase catabolic process (GO:0006208)4.02688889
30neuronal action potential (GO:0019228)4.01781535
31neurotransmitter-gated ion channel clustering (GO:0072578)3.94669268
32regulation of neuronal synaptic plasticity (GO:0048168)3.93028840
33presynaptic membrane organization (GO:0097090)3.88641325
34neurotransmitter secretion (GO:0007269)3.85836737
35regulation of excitatory postsynaptic membrane potential (GO:0060079)3.77940560
36dendrite morphogenesis (GO:0048813)3.77914528
37neuronal action potential propagation (GO:0019227)3.77451511
38regulation of synaptic vesicle transport (GO:1902803)3.76949017
39regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.74989007
40regulation of synapse structural plasticity (GO:0051823)3.74022768
41gamma-aminobutyric acid transport (GO:0015812)3.71692277
42membrane depolarization during action potential (GO:0086010)3.71002623
43gamma-aminobutyric acid signaling pathway (GO:0007214)3.65494396
44central nervous system projection neuron axonogenesis (GO:0021952)3.62724284
45regulation of postsynaptic membrane potential (GO:0060078)3.61779249
46long-term memory (GO:0007616)3.59269151
47transmission of nerve impulse (GO:0019226)3.58512169
48positive regulation of synapse maturation (GO:0090129)3.57092189
49regulation of dendritic spine morphogenesis (GO:0061001)3.55700104
50positive regulation of membrane potential (GO:0045838)3.53972202
51negative regulation of cytosolic calcium ion concentration (GO:0051481)3.53280168
52synaptic vesicle docking involved in exocytosis (GO:0016081)3.52384450
53auditory behavior (GO:0031223)3.47782105
54nucleobase catabolic process (GO:0046113)3.46488986
55G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.46361084
56establishment of mitochondrion localization (GO:0051654)3.38516533
57synapse assembly (GO:0007416)3.37131173
58regulation of synaptic transmission, glutamatergic (GO:0051966)3.33383897
59regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.33326227
60behavioral response to ethanol (GO:0048149)3.33137065
61startle response (GO:0001964)3.33022676
62response to histamine (GO:0034776)3.32067683
63serotonin metabolic process (GO:0042428)3.28657685
64regulation of synaptic plasticity (GO:0048167)3.28533342
65establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.25300342
66mitochondrion transport along microtubule (GO:0047497)3.25300342
67cell migration in hindbrain (GO:0021535)3.21871264
68positive regulation of synaptic transmission, GABAergic (GO:0032230)3.20636201
69positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.20212819
70long-term synaptic potentiation (GO:0060291)3.20094598
71response to auditory stimulus (GO:0010996)3.19986086
72primary amino compound metabolic process (GO:1901160)3.18586414
73neurotransmitter transport (GO:0006836)3.18085396
74activation of protein kinase A activity (GO:0034199)3.18036114
75negative regulation of synaptic transmission, GABAergic (GO:0032229)3.18009295
76behavioral fear response (GO:0001662)3.17305553
77behavioral defense response (GO:0002209)3.17305553
78innervation (GO:0060384)3.17128863
79positive regulation of synapse assembly (GO:0051965)3.17079746
80learning (GO:0007612)3.16767827
81regulation of dendritic spine development (GO:0060998)3.16116346
82cerebellar granule cell differentiation (GO:0021707)3.14951790
83protein polyglutamylation (GO:0018095)3.14653646
84membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.14462851
85organelle transport along microtubule (GO:0072384)3.13665604
86synaptic vesicle endocytosis (GO:0048488)3.11579025
87regulation of action potential (GO:0098900)3.11156866
88positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.09395783
89G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.08437316
90mechanosensory behavior (GO:0007638)3.07337661
91regulation of vesicle fusion (GO:0031338)3.07161149
92L-fucose catabolic process (GO:0042355)3.06891550
93fucose catabolic process (GO:0019317)3.06891550
94L-fucose metabolic process (GO:0042354)3.06891550
95negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05525915
96dendrite development (GO:0016358)3.05360173
97neuromuscular synaptic transmission (GO:0007274)3.05114884
98membrane depolarization (GO:0051899)3.04949388
99synapse organization (GO:0050808)3.03687794
100positive regulation of dendritic spine development (GO:0060999)3.02187427
101axon extension (GO:0048675)3.02094717
102regulation of neurotransmitter secretion (GO:0046928)3.00970004
103nonmotile primary cilium assembly (GO:0035058)3.00569017
104social behavior (GO:0035176)2.96817673
105intraspecies interaction between organisms (GO:0051703)2.96817673
106membrane hyperpolarization (GO:0060081)2.95966560
107fear response (GO:0042596)2.95788222
108positive regulation of dendritic spine morphogenesis (GO:0061003)2.95276113
109action potential (GO:0001508)2.93632198
110retinal ganglion cell axon guidance (GO:0031290)2.93085387
111cerebellum development (GO:0021549)2.93013773
112dendritic spine organization (GO:0097061)2.91793024
113central nervous system neuron axonogenesis (GO:0021955)2.91286755
114regulation of neurotransmitter levels (GO:0001505)2.90021854
115vesicle transport along microtubule (GO:0047496)2.89305458
116neuromuscular process controlling balance (GO:0050885)2.89180000
117synaptic transmission, cholinergic (GO:0007271)2.86198670
118cellular ketone body metabolic process (GO:0046950)2.85174761
119detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.84331314
120atrial cardiac muscle cell action potential (GO:0086014)2.83044252
121urinary tract smooth muscle contraction (GO:0014848)2.78409760
122protein localization to cilium (GO:0061512)2.77730639
123detection of light stimulus involved in sensory perception (GO:0050962)2.77410094
124detection of light stimulus involved in visual perception (GO:0050908)2.77410094
125positive regulation of action potential (GO:0045760)2.76695541
126reflex (GO:0060004)2.75706998
127indolalkylamine metabolic process (GO:0006586)2.72951896
128adult walking behavior (GO:0007628)2.71991702
129neuron maturation (GO:0042551)2.70702619
130adult behavior (GO:0030534)2.69089856
131tryptophan catabolic process (GO:0006569)2.67752791
132indole-containing compound catabolic process (GO:0042436)2.67752791
133indolalkylamine catabolic process (GO:0046218)2.67752791
134neurofilament cytoskeleton organization (GO:0060052)2.67289955
135indole-containing compound metabolic process (GO:0042430)2.65072514
136peristalsis (GO:0030432)2.64520751
137cAMP catabolic process (GO:0006198)2.63136236
138kynurenine metabolic process (GO:0070189)2.61530480
139spinal cord motor neuron differentiation (GO:0021522)2.59324670
140positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.56611812
141positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.55541933
142sulfation (GO:0051923)2.55410108
143ketone body metabolic process (GO:1902224)2.52944905
144epithelial cilium movement (GO:0003351)2.51805122
145calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.49939317
146positive regulation of potassium ion transmembrane transport (GO:1901381)2.48629241
147neural tube formation (GO:0001841)2.48217384
148positive regulation of sodium ion transmembrane transport (GO:1902307)2.45922768
149detection of mechanical stimulus involved in sensory perception (GO:0050974)2.42791695
150response to pheromone (GO:0019236)2.42360790

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.96384709
2GBX2_23144817_ChIP-Seq_PC3_Human4.06460075
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.99667077
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.99145335
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.87707242
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.50457176
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48544334
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.48270202
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.48270202
10* REST_21632747_ChIP-Seq_MESCs_Mouse2.47562333
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.40331824
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37211359
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.33116737
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.31608209
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.29130904
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.21741060
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.21165691
18DROSHA_22980978_ChIP-Seq_HELA_Human2.19759162
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15786087
20AR_21572438_ChIP-Seq_LNCaP_Human2.14839390
21TAF15_26573619_Chip-Seq_HEK293_Human2.14071103
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12819683
23* EZH2_27294783_Chip-Seq_ESCs_Mouse2.12268509
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.09648000
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08161090
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.01529454
27RARB_27405468_Chip-Seq_BRAIN_Mouse1.99163720
28* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98961064
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.97832369
30* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95329538
31* REST_18959480_ChIP-ChIP_MESCs_Mouse1.87355929
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.83216009
33* SMAD4_21799915_ChIP-Seq_A2780_Human1.77928679
34* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76675935
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74261345
36* P300_19829295_ChIP-Seq_ESCs_Human1.67753085
37ZNF274_21170338_ChIP-Seq_K562_Hela1.62018255
38EWS_26573619_Chip-Seq_HEK293_Human1.60366020
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56671877
40FUS_26573619_Chip-Seq_HEK293_Human1.52114610
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.51726054
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51169526
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50857799
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50787961
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.50256010
46* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48960729
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48173234
48IGF1R_20145208_ChIP-Seq_DFB_Human1.47883528
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.46499435
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43919581
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41813205
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41487097
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40101972
54* SOX2_21211035_ChIP-Seq_LN229_Gbm1.39668102
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38608788
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38130374
57* AR_25329375_ChIP-Seq_VCAP_Human1.38057117
58* FLI1_27457419_Chip-Seq_LIVER_Mouse1.35752017
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35362248
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35334007
61* STAT3_23295773_ChIP-Seq_U87_Human1.35252620
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29757087
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29082361
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28966482
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27744394
66CBP_20019798_ChIP-Seq_JUKART_Human1.27744394
67ARNT_22903824_ChIP-Seq_MCF-7_Human1.26137912
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25494837
69EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25192422
70RNF2_27304074_Chip-Seq_NSC_Mouse1.24889086
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.24472477
72MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23617995
73* RING1B_27294783_Chip-Seq_ESCs_Mouse1.22113832
74AHR_22903824_ChIP-Seq_MCF-7_Human1.18942781
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17762752
76ER_23166858_ChIP-Seq_MCF-7_Human1.17732916
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17721970
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17296015
79* TCF4_23295773_ChIP-Seq_U87_Human1.17275178
80ERG_21242973_ChIP-ChIP_JURKAT_Human1.16334879
81TP53_16413492_ChIP-PET_HCT116_Human1.15503302
82* AR_19668381_ChIP-Seq_PC3_Human1.14950804
83RING1B_27294783_Chip-Seq_NPCs_Mouse1.14925634
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13975009
85* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13701608
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13073252
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12159172
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12159172
89* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11540115
90VDR_22108803_ChIP-Seq_LS180_Human1.10561012
91TP53_18474530_ChIP-ChIP_U2OS_Human1.08965365
92RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08646575
93* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08616868
94PRDM14_20953172_ChIP-Seq_ESCs_Human1.08462624
95KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08099843
96RUNX2_22187159_ChIP-Seq_PCA_Human1.07892304
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06864094
98TCF4_22108803_ChIP-Seq_LS180_Human1.06431049
99JUN_21703547_ChIP-Seq_K562_Human1.05695740
100WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04006999
101FLI1_21867929_ChIP-Seq_TH2_Mouse1.03587354
102* NANOG_18555785_Chip-Seq_ESCs_Mouse1.03244930
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02597777
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02475102
105KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02300776
106* TP53_22573176_ChIP-Seq_HFKS_Human1.01729626
107SMAD4_21741376_ChIP-Seq_EPCs_Human1.00856664
108EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99844020
109MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99666918
110PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99359983
111TAL1_26923725_Chip-Seq_HPCs_Mouse0.98930327
112ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98753490
113* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98529950
114SOX2_19829295_ChIP-Seq_ESCs_Human0.98150564
115NANOG_19829295_ChIP-Seq_ESCs_Human0.98150564
116* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97674465
117CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97533688
118SMAD3_21741376_ChIP-Seq_ESCs_Human0.96662074
119* P53_22387025_ChIP-Seq_ESCs_Mouse0.96435878
120* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95429236
121BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94091232
122SMAD4_21741376_ChIP-Seq_HESCs_Human0.92845985
123* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92646665
124BCAT_22108803_ChIP-Seq_LS180_Human0.92608055
125* KDM2B_26808549_Chip-Seq_REH_Human0.90992633

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.07485207
2MP0003880_abnormal_central_pattern4.58485793
3MP0004270_analgesia4.21402558
4MP0003635_abnormal_synaptic_transmissio4.05901748
5MP0002063_abnormal_learning/memory/cond3.36628516
6MP0009745_abnormal_behavioral_response3.30529879
7MP0002064_seizures2.98519816
8MP0005423_abnormal_somatic_nervous2.98335025
9MP0001968_abnormal_touch/_nociception2.85222538
10MP0002572_abnormal_emotion/affect_behav2.83858829
11MP0002734_abnormal_mechanical_nocicepti2.81868539
12MP0009046_muscle_twitch2.76553943
13MP0001486_abnormal_startle_reflex2.65824709
14MP0002735_abnormal_chemical_nociception2.49012350
15MP0002272_abnormal_nervous_system2.46948375
16MP0000778_abnormal_nervous_system2.43632883
17MP0001440_abnormal_grooming_behavior2.22850745
18MP0002733_abnormal_thermal_nociception2.16815439
19MP0001501_abnormal_sleep_pattern2.16157491
20MP0002736_abnormal_nociception_after2.13600293
21MP0003329_amyloid_beta_deposits2.08522194
22MP0006276_abnormal_autonomic_nervous2.04497041
23MP0002184_abnormal_innervation2.04081634
24MP0002067_abnormal_sensory_capabilities1.96754409
25MP0004924_abnormal_behavior1.96693233
26MP0005386_behavior/neurological_phenoty1.96693233
27MP0001529_abnormal_vocalization1.95986112
28MP0001970_abnormal_pain_threshold1.95843956
29MP0009780_abnormal_chondrocyte_physiolo1.91672207
30MP0002557_abnormal_social/conspecific_i1.85620808
31MP0004811_abnormal_neuron_physiology1.74015606
32MP0008877_abnormal_DNA_methylation1.68091019
33MP0002822_catalepsy1.65973334
34MP0004858_abnormal_nervous_system1.62356188
35MP0000955_abnormal_spinal_cord1.62291990
36MP0003195_calcinosis1.62204162
37MP0008569_lethality_at_weaning1.60942565
38MP0003787_abnormal_imprinting1.59262301
39MP0002882_abnormal_neuron_morphology1.51095296
40MP0001984_abnormal_olfaction1.50368418
41MP0005645_abnormal_hypothalamus_physiol1.49269477
42MP0006292_abnormal_olfactory_placode1.48305622
43MP0002909_abnormal_adrenal_gland1.47831583
44MP0002066_abnormal_motor_capabilities/c1.45327077
45MP0001188_hyperpigmentation1.44471211
46MP0001905_abnormal_dopamine_level1.43064601
47MP0004885_abnormal_endolymph1.42309781
48MP0004133_heterotaxia1.41737746
49MP0000569_abnormal_digit_pigmentation1.39336581
50MP0005646_abnormal_pituitary_gland1.34209424
51MP0003879_abnormal_hair_cell1.32568737
52MP0003121_genomic_imprinting1.28631536
53MP0003890_abnormal_embryonic-extraembry1.27636206
54MP0002152_abnormal_brain_morphology1.25079512
55MP0005409_darkened_coat_color1.21570179
56MP0004142_abnormal_muscle_tone1.19723512
57MP0003633_abnormal_nervous_system1.19635183
58MP0001986_abnormal_taste_sensitivity1.19502574
59MP0005253_abnormal_eye_physiology1.18847208
60MP0002653_abnormal_ependyma_morphology1.16044992
61MP0006072_abnormal_retinal_apoptosis1.13944496
62MP0004742_abnormal_vestibular_system1.12041631
63MP0003122_maternal_imprinting1.10014989
64MP0003631_nervous_system_phenotype1.09563784
65MP0002837_dystrophic_cardiac_calcinosis1.08290794
66MP0000631_abnormal_neuroendocrine_gland1.06822471
67MP0002876_abnormal_thyroid_physiology1.06500188
68MP0004043_abnormal_pH_regulation1.05640537
69MP0003119_abnormal_digestive_system1.04368066
70MP0001502_abnormal_circadian_rhythm1.03628755
71MP0000920_abnormal_myelination1.03582160
72MP0003283_abnormal_digestive_organ1.02931706
73MP0010386_abnormal_urinary_bladder1.01863341
74MP0002229_neurodegeneration1.00598083
75MP0003136_yellow_coat_color0.98908195
76MP0005551_abnormal_eye_electrophysiolog0.98549295
77MP0005195_abnormal_posterior_eye0.98364619
78MP0002751_abnormal_autonomic_nervous0.98253002
79MP0003634_abnormal_glial_cell0.97824472
80MP0002234_abnormal_pharynx_morphology0.97354613
81MP0004145_abnormal_muscle_electrophysio0.95848895
82MP0003646_muscle_fatigue0.94513461
83MP0000604_amyloidosis0.93747572
84MP0003011_delayed_dark_adaptation0.92551769
85MP0002938_white_spotting0.91943125
86MP0002069_abnormal_eating/drinking_beha0.91127044
87MP0001963_abnormal_hearing_physiology0.91052561
88MP0003632_abnormal_nervous_system0.89379367
89MP0002752_abnormal_somatic_nervous0.88584351
90MP0002928_abnormal_bile_duct0.88082748
91MP0004085_abnormal_heartbeat0.86964385
92MP0000427_abnormal_hair_cycle0.86093924
93MP0005084_abnormal_gallbladder_morpholo0.83600169
94MP0005174_abnormal_tail_pigmentation0.83248406
95MP0005499_abnormal_olfactory_system0.82018726
96MP0005394_taste/olfaction_phenotype0.82018726
97MP0001177_atelectasis0.81993023
98MP0005187_abnormal_penis_morphology0.81127134
99MP0008789_abnormal_olfactory_epithelium0.80594418
100MP0002160_abnormal_reproductive_system0.79165694
101MP0003137_abnormal_impulse_conducting0.77985916
102MP0003861_abnormal_nervous_system0.77589600
103MP0001348_abnormal_lacrimal_gland0.75047504
104MP0000566_synostosis0.74618104
105MP0004130_abnormal_muscle_cell0.74402030
106MP0008874_decreased_physiological_sensi0.74272648
107MP0004147_increased_porphyrin_level0.73786550
108MP0008872_abnormal_physiological_respon0.73281243
109MP0000751_myopathy0.72502844
110MP0001299_abnormal_eye_distance/0.71176196
111MP0003690_abnormal_glial_cell0.69707996
112MP0005535_abnormal_body_temperature0.69070976
113MP0001485_abnormal_pinna_reflex0.67117694
114MP0000026_abnormal_inner_ear0.66537602
115MP0004215_abnormal_myocardial_fiber0.62677906
116MP0004233_abnormal_muscle_weight0.61076028
117MP0004484_altered_response_of0.60021563
118MP0001943_abnormal_respiration0.59082884
119MP0002102_abnormal_ear_morphology0.58842623
120MP0001664_abnormal_digestion0.58249726
121MP0003938_abnormal_ear_development0.57626434
122MP0002638_abnormal_pupillary_reflex0.56011383
123MP0000013_abnormal_adipose_tissue0.55956394
124MP0004510_myositis0.54903669
125MP0005171_absent_coat_pigmentation0.54646644
126MP0010770_preweaning_lethality0.54536231
127MP0002082_postnatal_lethality0.54536231
128MP0010769_abnormal_survival0.54172252
129MP0002090_abnormal_vision0.53320007

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.02700822
2Focal seizures (HP:0007359)5.47626183
3Myokymia (HP:0002411)5.43249230
4Epileptic encephalopathy (HP:0200134)4.83906414
5Visual hallucinations (HP:0002367)4.68148621
6Atonic seizures (HP:0010819)4.28555927
7Hyperventilation (HP:0002883)4.27260374
8Absence seizures (HP:0002121)4.17187126
9Progressive cerebellar ataxia (HP:0002073)4.12055814
10Broad-based gait (HP:0002136)3.94330473
11Febrile seizures (HP:0002373)3.80292657
12Dialeptic seizures (HP:0011146)3.80062727
13Supranuclear gaze palsy (HP:0000605)3.73173249
14Abnormality of the corticospinal tract (HP:0002492)3.72032835
15Pancreatic cysts (HP:0001737)3.69636622
16Excessive salivation (HP:0003781)3.66362255
17Drooling (HP:0002307)3.66362255
18Molar tooth sign on MRI (HP:0002419)3.65592181
19Abnormality of midbrain morphology (HP:0002418)3.65592181
20Generalized tonic-clonic seizures (HP:0002069)3.58565848
21Neurofibrillary tangles (HP:0002185)3.57844998
22Congenital stationary night blindness (HP:0007642)3.57350708
23Cerebral inclusion bodies (HP:0100314)3.56518181
24Poor eye contact (HP:0000817)3.55807470
25Pancreatic fibrosis (HP:0100732)3.49741293
26Mutism (HP:0002300)3.49731894
27True hermaphroditism (HP:0010459)3.46653058
28Nephronophthisis (HP:0000090)3.42124953
29Termporal pattern (HP:0011008)3.40746149
30Insidious onset (HP:0003587)3.40746149
31Truncal ataxia (HP:0002078)3.36178183
32Action tremor (HP:0002345)3.31604664
33Amyotrophic lateral sclerosis (HP:0007354)3.17130449
34Abnormal social behavior (HP:0012433)3.16747092
35Impaired social interactions (HP:0000735)3.16747092
36Ankle clonus (HP:0011448)3.11048393
37Papilledema (HP:0001085)3.06490670
38Urinary bladder sphincter dysfunction (HP:0002839)2.99244574
39Impaired vibration sensation in the lower limbs (HP:0002166)2.97480115
40Epileptiform EEG discharges (HP:0011182)2.92474867
41Progressive inability to walk (HP:0002505)2.91634268
42Akinesia (HP:0002304)2.91049202
43Abnormality of the renal medulla (HP:0100957)2.88913474
44Gaze-evoked nystagmus (HP:0000640)2.87923271
45Degeneration of the lateral corticospinal tracts (HP:0002314)2.87369320
46Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.87369320
47Inappropriate behavior (HP:0000719)2.82404172
48Limb dystonia (HP:0002451)2.80903983
49EEG with generalized epileptiform discharges (HP:0011198)2.79356870
50Spastic gait (HP:0002064)2.76765486
51Medial flaring of the eyebrow (HP:0010747)2.76297627
52Polyphagia (HP:0002591)2.76162124
53Absent speech (HP:0001344)2.75495410
54Dysmetria (HP:0001310)2.72854384
55Dysdiadochokinesis (HP:0002075)2.72116969
56Diplopia (HP:0000651)2.72015672
57Abnormality of binocular vision (HP:0011514)2.72015672
58Genetic anticipation (HP:0003743)2.70029439
59Amblyopia (HP:0000646)2.68979812
60Inability to walk (HP:0002540)2.67811125
61Urinary urgency (HP:0000012)2.67339081
62Abnormal eating behavior (HP:0100738)2.65090441
63Hypsarrhythmia (HP:0002521)2.64183594
64Depression (HP:0000716)2.63714947
65Abnormality of the renal cortex (HP:0011035)2.60083548
66Abolished electroretinogram (ERG) (HP:0000550)2.58163110
67Abnormality of salivation (HP:0100755)2.57107811
68Fetal akinesia sequence (HP:0001989)2.52050463
69Chronic hepatic failure (HP:0100626)2.51814714
70Anxiety (HP:0000739)2.51598729
71Type II lissencephaly (HP:0007260)2.49217676
72Pendular nystagmus (HP:0012043)2.46316060
73Attenuation of retinal blood vessels (HP:0007843)2.42017503
74Cystic liver disease (HP:0006706)2.41361939
75Protruding tongue (HP:0010808)2.40829721
76Hemiparesis (HP:0001269)2.38751962
77Generalized myoclonic seizures (HP:0002123)2.38121779
78Scanning speech (HP:0002168)2.37604184
79Impaired smooth pursuit (HP:0007772)2.35582815
80Stereotypic behavior (HP:0000733)2.35393491
81Hypothermia (HP:0002045)2.34573158
82Congenital primary aphakia (HP:0007707)2.34211809
83Blue irides (HP:0000635)2.31877288
84Keratoconus (HP:0000563)2.30958650
85Increased corneal curvature (HP:0100692)2.30958650
86Absent/shortened dynein arms (HP:0200106)2.30377513
87Dynein arm defect of respiratory motile cilia (HP:0012255)2.30377513
88Gait imbalance (HP:0002141)2.29454804
89Agitation (HP:0000713)2.29337722
90Nephrogenic diabetes insipidus (HP:0009806)2.29046059
91Bony spicule pigmentary retinopathy (HP:0007737)2.27458546
92Pachygyria (HP:0001302)2.27384137
93Sclerocornea (HP:0000647)2.25124705
94Postural instability (HP:0002172)2.24280268
95Intention tremor (HP:0002080)2.22962170
96Lower limb muscle weakness (HP:0007340)2.21203100
97Congenital sensorineural hearing impairment (HP:0008527)2.19355092
98Genital tract atresia (HP:0001827)2.19342211
99Vaginal atresia (HP:0000148)2.18243732
100Megalencephaly (HP:0001355)2.18201129
101Aqueductal stenosis (HP:0002410)2.15452147
102Chorioretinal atrophy (HP:0000533)2.14494859
103Torticollis (HP:0000473)2.13932131
104Abnormality of the lower motor neuron (HP:0002366)2.12886837
105Abnormal drinking behavior (HP:0030082)2.11007800
106Polydipsia (HP:0001959)2.11007800
107Anencephaly (HP:0002323)2.09533293
108Morphological abnormality of the pyramidal tract (HP:0002062)2.08961197
109Decreased central vision (HP:0007663)2.05712309
110Concave nail (HP:0001598)2.05194139
111Pheochromocytoma (HP:0002666)2.03007349
112Generalized hypopigmentation of hair (HP:0011358)2.02535148
113Aplasia/Hypoplasia of the tibia (HP:0005772)2.02226309
114Widely spaced teeth (HP:0000687)2.00165643
115Bradykinesia (HP:0002067)1.99967978
116Furrowed tongue (HP:0000221)1.99654102
117Large for gestational age (HP:0001520)1.99527447
118Abnormality of ocular smooth pursuit (HP:0000617)1.99133388
119Congenital, generalized hypertrichosis (HP:0004540)1.98884950
120Hypoplasia of the brainstem (HP:0002365)1.98760631
121Aplasia/Hypoplasia of the brainstem (HP:0007362)1.98760631
122Impaired vibratory sensation (HP:0002495)1.97148467
123Exotropia (HP:0000577)1.97135828
124Abnormality of alanine metabolism (HP:0010916)1.94119157
125Hyperalaninemia (HP:0003348)1.94119157
126Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.94119157
127Renal cortical cysts (HP:0000803)1.93275279
128Focal dystonia (HP:0004373)1.93001377
129Optic nerve hypoplasia (HP:0000609)1.92711315
130Obstructive sleep apnea (HP:0002870)1.91516389
131Abnormal rod and cone electroretinograms (HP:0008323)1.90788071
132Abnormality of the labia minora (HP:0012880)1.89762961
133Decreased circulating renin level (HP:0003351)1.88384008
134Apathy (HP:0000741)1.87941168
135Fair hair (HP:0002286)1.87216580
136Specific learning disability (HP:0001328)1.86940948
137Gastroesophageal reflux (HP:0002020)1.86481999
138Poor coordination (HP:0002370)1.84774608
139Lissencephaly (HP:0001339)1.84235661
140Neuronal loss in central nervous system (HP:0002529)1.83789572
141Retinal dysplasia (HP:0007973)1.83292377
142Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.82967119
143Congenital hepatic fibrosis (HP:0002612)1.82822966
144Oligodactyly (hands) (HP:0001180)1.82726329
145Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82689309
146Male pseudohermaphroditism (HP:0000037)1.82417066
147Tubular atrophy (HP:0000092)1.82205310
148Abnormal respiratory epithelium morphology (HP:0012253)1.82086821
149Abnormal respiratory motile cilium morphology (HP:0005938)1.82086821
150Hyperthyroidism (HP:0000836)1.81136337
151Lower limb amyotrophy (HP:0007210)1.81107028
152Aplasia/Hypoplasia of the tongue (HP:0010295)1.80422684
153Sporadic (HP:0003745)1.79809146
154Narrow forehead (HP:0000341)1.79735445
155Patellar aplasia (HP:0006443)1.76400891
156Abnormal ciliary motility (HP:0012262)1.75575126
157Prolonged QT interval (HP:0001657)1.75296552
158Gait ataxia (HP:0002066)1.75096930
159Clumsiness (HP:0002312)1.74588902
160Psychosis (HP:0000709)1.74511649
161Thickened helices (HP:0000391)1.73661866
162Absent rod-and cone-mediated responses on ERG (HP:0007688)1.69800605
163Aplasia/Hypoplasia of the patella (HP:0006498)1.68255126
164Postaxial foot polydactyly (HP:0001830)1.68011096

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.64439938
2FRK3.99505115
3NTRK33.96948266
4MAP3K93.46425680
5EPHA43.26857393
6MAP3K43.21861567
7MAP2K72.72111936
8CASK2.71167563
9MINK12.63065533
10ADRBK22.60062732
11NTRK22.34890633
12PAK61.91482345
13NTRK11.89458023
14MAPK131.87320225
15DAPK21.86558169
16TNIK1.84857961
17INSRR1.84751723
18PNCK1.80869701
19SIK21.78106372
20KSR11.76561117
21MAP2K41.73067715
22GRK11.70986039
23PINK11.65856576
24RIPK41.62932638
25MAP3K121.61635538
26PLK21.57897656
27WNK41.56839147
28CDK51.51288560
29PHKG21.50308393
30PHKG11.50308393
31MAP4K21.49028802
32DYRK21.42877679
33ACVR1B1.41798079
34TLK11.39512745
35KSR21.34349909
36ERBB31.33629135
37DAPK11.25938337
38ZAK1.25674640
39PRPF4B1.18984982
40LATS21.18651128
41GRK51.14806278
42PRKCG1.14786127
43UHMK11.13556177
44CSNK1G21.12074267
45NUAK11.11758962
46MAP3K21.10845392
47CAMK2A1.08792960
48CAMKK11.07867966
49CDK191.05653814
50ADRBK11.01880749
51MKNK20.99740596
52WNK30.99185039
53CAMK2B0.98196630
54PAK30.96851880
55BCR0.92921581
56PKN10.90842207
57TAOK30.90765572
58OXSR10.89403462
59DYRK1A0.88781870
60PRKD30.86767556
61CDK140.86756813
62BMPR20.86661722
63CDK180.85921078
64TRIM280.84295027
65CDK150.82986223
66FES0.81639699
67RET0.80071406
68MARK20.76377185
69CSNK1G10.76102933
70STK110.74466125
71MAP3K60.74399282
72FGFR20.73346770
73EPHA30.72680908
74SGK2230.71984559
75SGK4940.71984559
76CDK11A0.71477212
77CAMKK20.71115105
78CCNB10.71017977
79MAPK150.69753464
80TYRO30.69507144
81PRKCE0.68573742
82SGK10.67419317
83TAF10.65393287
84FGR0.65360936
85DYRK30.64750617
86CAMK1G0.62949148
87CAMK10.60492472
88SCYL20.60177318
89STK390.59867670
90CSNK1G30.59576682
91TIE10.59321132
92PIK3CA0.58623480
93PRKCZ0.56690346
94CSNK1A1L0.56066273
95PRKACA0.54799175
96RAF10.54682293
97CAMK2D0.52328515
98STK380.50844223
99ARAF0.50633787
100FYN0.50561366
101FER0.50384805
102CAMK40.50334862
103GRK70.49955662
104SGK20.49590231
105MUSK0.49526739
106SIK30.48241588
107PTK2B0.47864140
108PRKCH0.46300332
109MAPK120.46214335
110NME10.45846454
111TGFBR10.43675611
112EPHB20.43622709
113CSNK1D0.43512482
114TXK0.43334055
115TAOK10.42178653
116ROCK20.41275708
117ALK0.41133481
118RPS6KA30.40293355
119MAPKAPK50.40061831
120ERBB20.38815164
121RPS6KA20.37759122
122MAPK100.36749238
123AKT30.36738808
124VRK10.36041446
125MAP2K10.35890781
126PDPK10.35819480
127CSNK1A10.35629016
128BMPR1B0.34931516
129PRKG10.34804933
130PRKACB0.34740555
131PDK10.34677446
132NEK60.34543011
133CSNK1E0.34118542
134PRKAA10.33972685
135PRKCA0.33473770
136SGK30.32719585
137CAMK2G0.32353840
138WNK10.31722747
139CDK30.31197099
140MAP2K60.30811732
141PRKCQ0.30161203
142PRKCB0.28701727
143RPS6KA50.28267927

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.99146291
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.82918860
3Synaptic vesicle cycle_Homo sapiens_hsa047212.74833531
4Circadian entrainment_Homo sapiens_hsa047132.72537280
5Glutamatergic synapse_Homo sapiens_hsa047242.71512293
6GABAergic synapse_Homo sapiens_hsa047272.71325014
7Long-term potentiation_Homo sapiens_hsa047202.67873550
8Morphine addiction_Homo sapiens_hsa050322.50724378
9Amphetamine addiction_Homo sapiens_hsa050312.37438015
10Olfactory transduction_Homo sapiens_hsa047402.33075087
11Dopaminergic synapse_Homo sapiens_hsa047282.25983589
12Salivary secretion_Homo sapiens_hsa049702.10073427
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.04772239
14Oxidative phosphorylation_Homo sapiens_hsa001902.04033854
15Cholinergic synapse_Homo sapiens_hsa047251.96057053
16Taste transduction_Homo sapiens_hsa047421.95654075
17Serotonergic synapse_Homo sapiens_hsa047261.94396895
18Linoleic acid metabolism_Homo sapiens_hsa005911.90795569
19Long-term depression_Homo sapiens_hsa047301.83818705
20Insulin secretion_Homo sapiens_hsa049111.80424199
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.80234712
22Renin secretion_Homo sapiens_hsa049241.76836066
23Gastric acid secretion_Homo sapiens_hsa049711.75247975
24Axon guidance_Homo sapiens_hsa043601.70836555
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.69277824
26Cocaine addiction_Homo sapiens_hsa050301.68386764
27Parkinsons disease_Homo sapiens_hsa050121.67395096
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.64094511
29Oxytocin signaling pathway_Homo sapiens_hsa049211.61666045
30Nitrogen metabolism_Homo sapiens_hsa009101.61256579
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53553666
32Calcium signaling pathway_Homo sapiens_hsa040201.50192564
33GnRH signaling pathway_Homo sapiens_hsa049121.44282748
34Ether lipid metabolism_Homo sapiens_hsa005651.44095929
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42095487
36Gap junction_Homo sapiens_hsa045401.40136878
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.31279674
38Collecting duct acid secretion_Homo sapiens_hsa049661.27738930
39Estrogen signaling pathway_Homo sapiens_hsa049151.23088505
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23037229
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22065873
42cAMP signaling pathway_Homo sapiens_hsa040241.20805056
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19692931
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17639620
45Type II diabetes mellitus_Homo sapiens_hsa049301.15961097
46ErbB signaling pathway_Homo sapiens_hsa040121.14813945
47Tryptophan metabolism_Homo sapiens_hsa003801.13592801
48Phototransduction_Homo sapiens_hsa047441.08730404
49Melanogenesis_Homo sapiens_hsa049161.07824237
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06972457
51Huntingtons disease_Homo sapiens_hsa050161.06597781
52Protein export_Homo sapiens_hsa030601.04762491
53Selenocompound metabolism_Homo sapiens_hsa004501.02676681
54Glioma_Homo sapiens_hsa052141.02385745
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02243178
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99280660
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97493229
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92382106
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.91904772
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90744223
61Vibrio cholerae infection_Homo sapiens_hsa051100.90698232
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88189076
63Cardiac muscle contraction_Homo sapiens_hsa042600.87340898
64Oocyte meiosis_Homo sapiens_hsa041140.86663955
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85859250
66Dorso-ventral axis formation_Homo sapiens_hsa043200.81896469
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.81005119
68Dilated cardiomyopathy_Homo sapiens_hsa054140.78560401
69Caffeine metabolism_Homo sapiens_hsa002320.77907873
70MAPK signaling pathway_Homo sapiens_hsa040100.77869394
71Pancreatic secretion_Homo sapiens_hsa049720.77282499
72Chemical carcinogenesis_Homo sapiens_hsa052040.77189453
73ABC transporters_Homo sapiens_hsa020100.77143941
74Choline metabolism in cancer_Homo sapiens_hsa052310.76382164
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.76369829
76Thyroid hormone synthesis_Homo sapiens_hsa049180.75941465
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75358470
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.71222747
79Ras signaling pathway_Homo sapiens_hsa040140.71177749
80Basal transcription factors_Homo sapiens_hsa030220.70359510
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69872747
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67037825
83Retinol metabolism_Homo sapiens_hsa008300.63825637
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63633164
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63421700
86Wnt signaling pathway_Homo sapiens_hsa043100.61570916
87Peroxisome_Homo sapiens_hsa041460.61339851
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60523844
89Renal cell carcinoma_Homo sapiens_hsa052110.60242075
90Alcoholism_Homo sapiens_hsa050340.60097656
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.59984157
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57035762
93VEGF signaling pathway_Homo sapiens_hsa043700.56986307
94Regulation of autophagy_Homo sapiens_hsa041400.56963285
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56362336
96Alzheimers disease_Homo sapiens_hsa050100.55528112
97Hedgehog signaling pathway_Homo sapiens_hsa043400.55234042
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54847909
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54724783
100Endometrial cancer_Homo sapiens_hsa052130.54660393
101Rap1 signaling pathway_Homo sapiens_hsa040150.53685487
102Ovarian steroidogenesis_Homo sapiens_hsa049130.53541283
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.52202239
104Glucagon signaling pathway_Homo sapiens_hsa049220.49628443
105Glycerolipid metabolism_Homo sapiens_hsa005610.49169354
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49133671
107Butanoate metabolism_Homo sapiens_hsa006500.48930101
108Colorectal cancer_Homo sapiens_hsa052100.47227192
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46629366
110Arachidonic acid metabolism_Homo sapiens_hsa005900.46579135
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45551137
112Steroid biosynthesis_Homo sapiens_hsa001000.44981493
113beta-Alanine metabolism_Homo sapiens_hsa004100.44743461
114Fat digestion and absorption_Homo sapiens_hsa049750.44717482
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44580657
116Prion diseases_Homo sapiens_hsa050200.44549093
117Histidine metabolism_Homo sapiens_hsa003400.41936952
118Propanoate metabolism_Homo sapiens_hsa006400.40548347
119RNA polymerase_Homo sapiens_hsa030200.39750975
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39672616
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39441263
122African trypanosomiasis_Homo sapiens_hsa051430.38844003
123Basal cell carcinoma_Homo sapiens_hsa052170.38471839
124Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37930850
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37863524
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37573827
127mTOR signaling pathway_Homo sapiens_hsa041500.37194543
128Fatty acid biosynthesis_Homo sapiens_hsa000610.37174947
129Type I diabetes mellitus_Homo sapiens_hsa049400.37028004
130Endocytosis_Homo sapiens_hsa041440.36794345
131Insulin signaling pathway_Homo sapiens_hsa049100.33991845
132Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33213330
133Mineral absorption_Homo sapiens_hsa049780.31493803
134Chemokine signaling pathway_Homo sapiens_hsa040620.30604488
135Bile secretion_Homo sapiens_hsa049760.30090758
136Non-small cell lung cancer_Homo sapiens_hsa052230.29934720
137Hippo signaling pathway_Homo sapiens_hsa043900.29800199
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.28710993
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28704560
140Circadian rhythm_Homo sapiens_hsa047100.28066753
141Inositol phosphate metabolism_Homo sapiens_hsa005620.26213534

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