XKR5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)6.12409355
2protein localization to kinetochore (GO:0034501)5.48614378
3DNA strand elongation involved in DNA replication (GO:0006271)5.34198723
4DNA strand elongation (GO:0022616)5.07033555
5DNA replication initiation (GO:0006270)5.05664377
6behavioral response to nicotine (GO:0035095)4.88480518
7telomere maintenance via semi-conservative replication (GO:0032201)4.85131792
8DNA replication checkpoint (GO:0000076)4.51593167
9maturation of 5.8S rRNA (GO:0000460)4.50281204
10protein localization to chromosome, centromeric region (GO:0071459)4.49389501
11ribosomal small subunit assembly (GO:0000028)4.41698730
12DNA replication-dependent nucleosome assembly (GO:0006335)4.35293055
13DNA replication-dependent nucleosome organization (GO:0034723)4.35293055
14mitotic recombination (GO:0006312)4.32693147
15mitotic sister chromatid segregation (GO:0000070)4.32392775
16telomere maintenance via recombination (GO:0000722)4.30448473
17platelet dense granule organization (GO:0060155)4.21516880
18folic acid-containing compound biosynthetic process (GO:0009396)4.18644573
19fucose catabolic process (GO:0019317)4.14370933
20L-fucose metabolic process (GO:0042354)4.14370933
21L-fucose catabolic process (GO:0042355)4.14370933
22mitotic metaphase plate congression (GO:0007080)4.13943201
23sister chromatid segregation (GO:0000819)4.12133292
24maturation of SSU-rRNA (GO:0030490)4.08656794
25tryptophan catabolic process (GO:0006569)4.06346740
26indole-containing compound catabolic process (GO:0042436)4.06346740
27indolalkylamine catabolic process (GO:0046218)4.06346740
28nuclear pore organization (GO:0006999)4.04016681
29formation of translation preinitiation complex (GO:0001731)3.99517966
30kinetochore organization (GO:0051383)3.98182938
31response to pheromone (GO:0019236)3.98101206
32DNA duplex unwinding (GO:0032508)3.97087393
33indolalkylamine metabolic process (GO:0006586)3.94991218
34DNA geometric change (GO:0032392)3.94054100
35DNA double-strand break processing (GO:0000729)3.92951193
36mitotic nuclear envelope disassembly (GO:0007077)3.90707781
37IMP biosynthetic process (GO:0006188)3.87108827
38nuclear pore complex assembly (GO:0051292)3.86231504
39viral transcription (GO:0019083)3.85870403
40telomere maintenance via telomere lengthening (GO:0010833)3.83826491
41nucleotide-excision repair, DNA gap filling (GO:0006297)3.82929674
42mitotic chromosome condensation (GO:0007076)3.82754492
43regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.78874924
44chromatin remodeling at centromere (GO:0031055)3.78735949
45translational termination (GO:0006415)3.77130528
46protein import into peroxisome matrix (GO:0016558)3.76912389
47CENP-A containing nucleosome assembly (GO:0034080)3.75401336
48regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.75148949
49tryptophan metabolic process (GO:0006568)3.72504936
50metaphase plate congression (GO:0051310)3.66635502
51somatic diversification of immune receptors via somatic mutation (GO:0002566)3.66615075
52somatic hypermutation of immunoglobulin genes (GO:0016446)3.66615075
53heterochromatin organization (GO:0070828)3.63731983
54negative regulation of protein oligomerization (GO:0032460)3.60723361
55nuclear envelope disassembly (GO:0051081)3.60405926
56membrane disassembly (GO:0030397)3.60405926
57protein-cofactor linkage (GO:0018065)3.57119977
58DNA replication-independent nucleosome organization (GO:0034724)3.54712283
59DNA replication-independent nucleosome assembly (GO:0006336)3.54712283
60ribosomal small subunit biogenesis (GO:0042274)3.54236376
61nucleotide transmembrane transport (GO:1901679)3.54036091
62kinetochore assembly (GO:0051382)3.52941520
63rRNA catabolic process (GO:0016075)3.50027584
64kynurenine metabolic process (GO:0070189)3.48870814
65nucleobase biosynthetic process (GO:0046112)3.48083502
66regulation of nuclear cell cycle DNA replication (GO:0033262)3.47274217
67translational elongation (GO:0006414)3.43305745
68regulation of posttranscriptional gene silencing (GO:0060147)3.41500237
69regulation of gene silencing by miRNA (GO:0060964)3.41500237
70regulation of gene silencing by RNA (GO:0060966)3.41500237
71establishment of chromosome localization (GO:0051303)3.40497463
72regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.39711435
73attachment of spindle microtubules to kinetochore (GO:0008608)3.38890902
74IMP metabolic process (GO:0046040)3.37255812
75detection of light stimulus involved in visual perception (GO:0050908)3.36664779
76detection of light stimulus involved in sensory perception (GO:0050962)3.36664779
77negative regulation of telomere maintenance (GO:0032205)3.36558637
78nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.33756810
79positive regulation of chromosome segregation (GO:0051984)3.32203085
80DNA conformation change (GO:0071103)3.27124352
81translational initiation (GO:0006413)3.27101329
82chromatin assembly or disassembly (GO:0006333)3.24260637
83establishment of integrated proviral latency (GO:0075713)3.24247984
84negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.23963098
85cellular ketone body metabolic process (GO:0046950)3.23912128
86sulfation (GO:0051923)3.23198633
87replication fork processing (GO:0031297)3.22588700
88adaptation of signaling pathway (GO:0023058)3.22485569
89regulation of spindle organization (GO:0090224)3.22018972
90detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.21464142
91axoneme assembly (GO:0035082)3.20836522
92water-soluble vitamin biosynthetic process (GO:0042364)3.15576476
93meiotic chromosome segregation (GO:0045132)3.13595138
94ribonucleoprotein complex biogenesis (GO:0022613)3.13066552
95regulation of histone H3-K9 methylation (GO:0051570)3.11852201
96piRNA metabolic process (GO:0034587)3.11190546
97mismatch repair (GO:0006298)3.10010306
98SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.08889101
99histone exchange (GO:0043486)3.08771841
100ribosome biogenesis (GO:0042254)3.08126347
101mannosylation (GO:0097502)3.07965321
102regulation of double-strand break repair via homologous recombination (GO:0010569)3.07798638
103DNA topological change (GO:0006265)3.07490780
104base-excision repair (GO:0006284)3.05552917
105regulation of translational fidelity (GO:0006450)3.05398920
106negative regulation of RNA splicing (GO:0033119)3.04947155
107chromatin assembly (GO:0031497)3.04402459
108ribosomal large subunit biogenesis (GO:0042273)3.02689672
109telomere maintenance (GO:0000723)3.01687403
110protein localization to chromosome (GO:0034502)3.00887835
111ketone body metabolic process (GO:1902224)3.00743968
112cellular protein complex disassembly (GO:0043624)2.99991040
113cotranslational protein targeting to membrane (GO:0006613)2.99927200
114telomere organization (GO:0032200)2.99466507
115regulation of chromosome segregation (GO:0051983)2.99108614
116protein targeting to ER (GO:0045047)2.99070031
117maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.98704792
118pore complex assembly (GO:0046931)2.97851235
119pre-miRNA processing (GO:0031054)2.96588351
120recombinational repair (GO:0000725)2.93288352
121viral life cycle (GO:0019058)2.92584543
122positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.92572629
123positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.92572629
124positive regulation of mitotic sister chromatid separation (GO:1901970)2.92572629
125negative regulation of chromosome segregation (GO:0051985)2.92477005
126regulation of sister chromatid cohesion (GO:0007063)2.92419270
127double-strand break repair via homologous recombination (GO:0000724)2.92360463
128negative regulation of mast cell activation (GO:0033004)2.92103290
129regulation of centrosome cycle (GO:0046605)2.91577727
130epithelial cilium movement (GO:0003351)2.91075948
131cornea development in camera-type eye (GO:0061303)2.89713538
132cytidine metabolic process (GO:0046087)2.89369519
133cytidine catabolic process (GO:0006216)2.89369519
134cytidine deamination (GO:0009972)2.89369519
135gamma-aminobutyric acid transport (GO:0015812)2.88938255
136regulation of double-strand break repair (GO:2000779)2.88927447
137RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.88199756
138negative regulation of mRNA processing (GO:0050686)2.88065394
139chromosome segregation (GO:0007059)2.87479526
140retinal cone cell development (GO:0046549)2.86893461
141purine nucleobase biosynthetic process (GO:0009113)2.86865213
142respiratory chain complex IV assembly (GO:0008535)2.86829679
143DNA deamination (GO:0045006)2.86738834
144rRNA processing (GO:0006364)2.86180748
145amine catabolic process (GO:0009310)2.85960386
146cellular biogenic amine catabolic process (GO:0042402)2.85960386
147indole-containing compound metabolic process (GO:0042430)2.83387561
148glycerophospholipid catabolic process (GO:0046475)2.82132417
149kidney morphogenesis (GO:0060993)2.81980789
150neural tube formation (GO:0001841)2.78283607
151behavioral response to ethanol (GO:0048149)2.78068573
152epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.76143683
153multicellular organism reproduction (GO:0032504)2.74797461
154protein localization to cilium (GO:0061512)2.72578893
155preassembly of GPI anchor in ER membrane (GO:0016254)2.71730056
156signal peptide processing (GO:0006465)2.69946519
157protein K11-linked deubiquitination (GO:0035871)2.65811459
158photoreceptor cell maintenance (GO:0045494)2.63826145
159aromatic amino acid family catabolic process (GO:0009074)2.63153073
160positive regulation of prostaglandin secretion (GO:0032308)2.58748023
161neuronal action potential (GO:0019228)2.58671508
162positive regulation of fatty acid transport (GO:2000193)2.58636286
163centriole replication (GO:0007099)2.58422625
164negative regulation of cytosolic calcium ion concentration (GO:0051481)2.57621512
165reciprocal meiotic recombination (GO:0007131)2.57180730
166reciprocal DNA recombination (GO:0035825)2.57180730
167regulation of telomere maintenance (GO:0032204)2.54507092
168rhodopsin mediated signaling pathway (GO:0016056)2.52477195
169cilium morphogenesis (GO:0060271)2.51734959
170protein targeting to peroxisome (GO:0006625)2.51063392
171establishment of protein localization to peroxisome (GO:0072663)2.51063392
172protein localization to peroxisome (GO:0072662)2.51063392
173regulation of rhodopsin mediated signaling pathway (GO:0022400)2.50861562
174positive regulation of defense response to virus by host (GO:0002230)2.50278967
175negative regulation of DNA-dependent DNA replication (GO:2000104)2.49367562
176protein polyglutamylation (GO:0018095)2.48993451
177cilium or flagellum-dependent cell motility (GO:0001539)2.48943146
178regulation of meiosis I (GO:0060631)2.48097480
179pyrimidine ribonucleoside catabolic process (GO:0046133)2.47748716
180cytochrome complex assembly (GO:0017004)2.47046373
181dopamine transport (GO:0015872)2.46400354
182protein complex biogenesis (GO:0070271)2.45921243
183G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.45326873
184reflex (GO:0060004)2.42951893
185cilium movement (GO:0003341)2.42940695
186protein prenylation (GO:0018342)2.42495297
187prenylation (GO:0097354)2.42495297
188cAMP catabolic process (GO:0006198)2.41436683
189L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.40409633
190cilium organization (GO:0044782)2.40190466
191synapsis (GO:0007129)2.39790159
192drug catabolic process (GO:0042737)2.38571113
193photoreceptor cell development (GO:0042461)2.38452464
194DNA methylation involved in gamete generation (GO:0043046)2.37934176
195regulation of action potential (GO:0098900)2.37676914
196ncRNA catabolic process (GO:0034661)2.37164013
197exogenous drug catabolic process (GO:0042738)2.37148328
198branched-chain amino acid catabolic process (GO:0009083)2.35138191

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.88965729
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.09217981
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.03858099
4ZNF274_21170338_ChIP-Seq_K562_Hela3.90849381
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.49358159
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.35389248
7VDR_22108803_ChIP-Seq_LS180_Human3.18677150
8GBX2_23144817_ChIP-Seq_PC3_Human3.07444171
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.04412857
10IGF1R_20145208_ChIP-Seq_DFB_Human2.79169696
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.65011886
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.58068225
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.56335981
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.47996575
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46232156
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.41794307
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36860912
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.32114573
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.28000848
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20568852
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.16888524
22XRN2_22483619_ChIP-Seq_HELA_Human2.16798028
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.13896856
24CTBP1_25329375_ChIP-Seq_LNCAP_Human2.12890534
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12467622
26EWS_26573619_Chip-Seq_HEK293_Human2.11034159
27AR_21909140_ChIP-Seq_LNCAP_Human2.10338875
28P300_19829295_ChIP-Seq_ESCs_Human2.08116903
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.07286855
30ETS1_20019798_ChIP-Seq_JURKAT_Human2.04525619
31FUS_26573619_Chip-Seq_HEK293_Human2.03036490
32MYC_22102868_ChIP-Seq_BL_Human2.02513718
33* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.02199113
34E2F7_22180533_ChIP-Seq_HELA_Human10.4412190
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98422550
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.98080016
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.95951901
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.93721922
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.92359232
40ER_23166858_ChIP-Seq_MCF-7_Human1.90761815
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.84028623
42TAF15_26573619_Chip-Seq_HEK293_Human1.82478824
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.80423367
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.78007608
45* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77771903
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.77061569
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.76805783
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.76410504
49SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.76353972
50IRF1_19129219_ChIP-ChIP_H3396_Human1.75832633
51KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.74271219
52FOXP3_21729870_ChIP-Seq_TREG_Human1.70446526
53VDR_23849224_ChIP-Seq_CD4+_Human1.69145809
54BCAT_22108803_ChIP-Seq_LS180_Human1.69017859
55* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68150408
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67285110
57TTF2_22483619_ChIP-Seq_HELA_Human1.64777870
58DCP1A_22483619_ChIP-Seq_HELA_Human1.62621729
59KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.62496310
60KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.62496310
61KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.62496310
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60337568
63* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60281121
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60082868
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.59177525
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.58858393
67CIITA_25753668_ChIP-Seq_RAJI_Human1.58066188
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.55861591
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55691496
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53831669
71CBP_20019798_ChIP-Seq_JUKART_Human1.53831669
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53642412
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53048460
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.52782776
75STAT3_23295773_ChIP-Seq_U87_Human1.52412386
76TP53_22573176_ChIP-Seq_HFKS_Human1.49271972
77SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49105013
78SOX2_19829295_ChIP-Seq_ESCs_Human1.48616097
79NANOG_19829295_ChIP-Seq_ESCs_Human1.48616097
80THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47691476
81SMAD4_21799915_ChIP-Seq_A2780_Human1.47600808
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47367462
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46887000
84ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44984357
85AR_25329375_ChIP-Seq_VCAP_Human1.44010156
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43343771
87VDR_21846776_ChIP-Seq_THP-1_Human1.43177875
88PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43026934
89GABP_19822575_ChIP-Seq_HepG2_Human1.41680699
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40556280
91TCF4_23295773_ChIP-Seq_U87_Human1.40327521
92EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.39975718
93ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39640183
94SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39117585
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38852939
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.37632694
97SOX2_18555785_ChIP-Seq_MESCs_Mouse1.37617086
98EZH2_27294783_Chip-Seq_NPCs_Mouse1.36525507
99EZH2_22144423_ChIP-Seq_EOC_Human1.35063317
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33868214
101PIAS1_25552417_ChIP-Seq_VCAP_Human1.33447285
102GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32938375
103* FOXA1_25329375_ChIP-Seq_VCAP_Human1.31255279
104* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31255279
105* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31015394
106STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30518392
107ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30239219
108PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29393770
109YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28610048
110KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27951726
111ELK1_19687146_ChIP-ChIP_HELA_Human1.27351561
112SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27132906
113TCF4_22108803_ChIP-Seq_LS180_Human1.26790384
114YY1_21170310_ChIP-Seq_MESCs_Mouse1.26010850
115NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25872521
116KDM5A_27292631_Chip-Seq_BREAST_Human1.24522838
117TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24288802
118SMAD3_21741376_ChIP-Seq_EPCs_Human1.22740019
119CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21563046
120AR_21572438_ChIP-Seq_LNCaP_Human1.20938463
121CRX_20693478_ChIP-Seq_RETINA_Mouse1.19933249
122ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19645509
123KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18861831
124KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18825561
125ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18614502
126* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18570898
127SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18056712
128RUNX2_22187159_ChIP-Seq_PCA_Human1.18053981
129TCF3_18692474_ChIP-Seq_MEFs_Mouse1.17574715
130* AR_20517297_ChIP-Seq_VCAP_Human1.16831606
131HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15235697
132NANOG_18555785_Chip-Seq_ESCs_Mouse1.15157825
133EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14742436
134P53_22387025_ChIP-Seq_ESCs_Mouse1.14129874
135* GATA3_21878914_ChIP-Seq_MCF-7_Human1.13887486
136KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13243793
137E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.12997268
138TFEB_21752829_ChIP-Seq_HELA_Human1.12946647
139* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12030178
140* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11980402
141RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11789625
142ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11360440
143TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10924214
144E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10468211
145DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10430299
146POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10409956
147TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10409956
148NCOR_22424771_ChIP-Seq_293T_Human1.10075334
149AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09899511
150EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08621955
151RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08156532
152* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08143483
153FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07268374
154FLI1_21867929_ChIP-Seq_TH2_Mouse1.06858934
155ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05585777
156ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05341685
157BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05138029
158STAT3_18555785_Chip-Seq_ESCs_Mouse1.04954871
159PRDM14_20953172_ChIP-Seq_ESCs_Human1.04939898
160SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03391488
161CDX2_22108803_ChIP-Seq_LS180_Human1.03381715
162NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.03192289
163* SMAD4_21741376_ChIP-Seq_EPCs_Human1.03005679
164* HOXB7_26014856_ChIP-Seq_BT474_Human1.01343168
165RNF2_27304074_Chip-Seq_NSC_Mouse1.01143355
166CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00918155
167SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99764655
168TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99256675
169GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.97818074
170TCF3_18692474_ChIP-Seq_MESCs_Mouse0.97662343
171MYC_19829295_ChIP-Seq_ESCs_Human0.97411775
172PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96907964
173CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95930485
174NANOG_21062744_ChIP-ChIP_HESCs_Human0.95807282
175FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95678358
176GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89300646
177CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88790203
178NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87727382
179ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87713123
180SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.87543147
181NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.86851327
182SRF_21415370_ChIP-Seq_HL-1_Mouse0.86414434
183OCT4_18692474_ChIP-Seq_MEFs_Mouse0.86301825
184MYC_18940864_ChIP-ChIP_HL60_Human0.85443441
185PADI4_21655091_ChIP-ChIP_MCF-7_Human0.83564604
186ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82859184
187SPI1_23547873_ChIP-Seq_NB4_Human0.82692031
188SOX2_18692474_ChIP-Seq_MEFs_Mouse0.82237401
189NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.79942767
190CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79938610

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.63757344
2MP0010094_abnormal_chromosome_stability4.61531150
3MP0003693_abnormal_embryo_hatching4.37972068
4MP0003111_abnormal_nucleus_morphology4.24105439
5MP0004957_abnormal_blastocyst_morpholog4.14454210
6MP0002254_reproductive_system_inflammat4.05553700
7MP0003077_abnormal_cell_cycle3.82750230
8MP0003195_calcinosis3.32327273
9MP0010352_gastrointestinal_tract_polyps3.00262812
10MP0002837_dystrophic_cardiac_calcinosis2.94524032
11MP0008058_abnormal_DNA_repair2.91984446
12MP0003123_paternal_imprinting2.66896183
13MP0002102_abnormal_ear_morphology2.58046517
14MP0008007_abnormal_cellular_replicative2.52717304
15MP0002396_abnormal_hematopoietic_system2.52093858
16MP0008932_abnormal_embryonic_tissue2.49013906
17MP0002876_abnormal_thyroid_physiology2.47464295
18MP0006072_abnormal_retinal_apoptosis2.40574144
19MP0005551_abnormal_eye_electrophysiolog2.31990274
20MP0000372_irregular_coat_pigmentation2.30827445
21MP0001968_abnormal_touch/_nociception2.30447162
22MP0000350_abnormal_cell_proliferation2.23177347
23MP0001730_embryonic_growth_arrest2.20702734
24MP0008872_abnormal_physiological_respon2.15719466
25MP0002736_abnormal_nociception_after2.08858177
26MP0009046_muscle_twitch1.98123734
27MP0010307_abnormal_tumor_latency1.96983417
28MP0005253_abnormal_eye_physiology1.85175894
29MP0000569_abnormal_digit_pigmentation1.82702690
30MP0004043_abnormal_pH_regulation1.82681788
31MP0000490_abnormal_crypts_of1.82677447
32MP0001672_abnormal_embryogenesis/_devel1.82603956
33MP0005380_embryogenesis_phenotype1.82603956
34MP0010030_abnormal_orbit_morphology1.78547382
35MP0001697_abnormal_embryo_size1.73756148
36MP0001986_abnormal_taste_sensitivity1.73315769
37MP0001984_abnormal_olfaction1.73129630
38MP0006082_CNS_inflammation1.72813425
39MP0002638_abnormal_pupillary_reflex1.71792916
40MP0003121_genomic_imprinting1.71033059
41MP0003890_abnormal_embryonic-extraembry1.65465582
42MP0004197_abnormal_fetal_growth/weight/1.63902536
43MP0003646_muscle_fatigue1.63812375
44MP0002085_abnormal_embryonic_tissue1.63367112
45MP0009745_abnormal_behavioral_response1.63115245
46MP0003984_embryonic_growth_retardation1.62193769
47MP0005646_abnormal_pituitary_gland1.62019110
48MP0003705_abnormal_hypodermis_morpholog1.61445374
49MP0004142_abnormal_muscle_tone1.61235256
50MP0002088_abnormal_embryonic_growth/wei1.60781971
51MP0002084_abnormal_developmental_patter1.58062042
52MP0003880_abnormal_central_pattern1.56764231
53MP0002080_prenatal_lethality1.56529832
54MP0004808_abnormal_hematopoietic_stem1.56423211
55MP0003786_premature_aging1.56008613
56MP0002086_abnormal_extraembryonic_tissu1.55169270
57MP0009278_abnormal_bone_marrow1.54153186
58MP0005645_abnormal_hypothalamus_physiol1.50492279
59MP0008875_abnormal_xenobiotic_pharmacok1.50101223
60MP0003136_yellow_coat_color1.49756244
61MP0004885_abnormal_endolymph1.49704719
62MP0003567_abnormal_fetal_cardiomyocyte1.49426968
63MP0005076_abnormal_cell_differentiation1.48943504
64MP0001501_abnormal_sleep_pattern1.48461158
65MP0001293_anophthalmia1.44294376
66MP0002019_abnormal_tumor_incidence1.44247015
67MP0000313_abnormal_cell_death1.43381163
68MP0002272_abnormal_nervous_system1.42472122
69MP0004133_heterotaxia1.40974873
70MP0001545_abnormal_hematopoietic_system1.39914174
71MP0005397_hematopoietic_system_phenotyp1.39914174
72MP0008877_abnormal_DNA_methylation1.37660544
73MP0000631_abnormal_neuroendocrine_gland1.35323643
74MP0000427_abnormal_hair_cycle1.32264789
75MP0009697_abnormal_copulation1.30668692
76MP0004147_increased_porphyrin_level1.30345535
77MP0006292_abnormal_olfactory_placode1.26191704
78MP0010386_abnormal_urinary_bladder1.25885906
79MP0001873_stomach_inflammation1.25264623
80MP0005410_abnormal_fertilization1.23337325
81MP0005389_reproductive_system_phenotype1.19057147
82MP0002163_abnormal_gland_morphology1.17132799
83MP0000703_abnormal_thymus_morphology1.16455133
84MP0003718_maternal_effect1.16176598
85MP0005671_abnormal_response_to1.14188338
86MP0005379_endocrine/exocrine_gland_phen1.11410421
87MP0001919_abnormal_reproductive_system1.10751723
88MP0005085_abnormal_gallbladder_physiolo1.10708020
89MP0001486_abnormal_startle_reflex1.08638164
90MP0006276_abnormal_autonomic_nervous1.07374762
91MP0003119_abnormal_digestive_system1.06089750
92MP0002398_abnormal_bone_marrow1.04331269
93MP0009333_abnormal_splenocyte_physiolog1.03386786
94MP0001485_abnormal_pinna_reflex1.02946975
95MP0002722_abnormal_immune_system1.02766485
96MP0008995_early_reproductive_senescence1.02230821
97MP0006054_spinal_hemorrhage1.02055514
98MP0002653_abnormal_ependyma_morphology0.99844297
99MP0000858_altered_metastatic_potential0.98611256
100MP0003698_abnormal_male_reproductive0.97835012
101MP0002111_abnormal_tail_morphology0.97190218
102MP0002277_abnormal_respiratory_mucosa0.95866103
103MP0000689_abnormal_spleen_morphology0.95331913
104MP0002160_abnormal_reproductive_system0.94396570
105MP0002693_abnormal_pancreas_physiology0.94250595
106MP0002735_abnormal_chemical_nociception0.93939228
107MP0002064_seizures0.93815440
108MP0005023_abnormal_wound_healing0.93074056
109MP0005167_abnormal_blood-brain_barrier0.92758121
110MP0003011_delayed_dark_adaptation0.92327201
111MP0002751_abnormal_autonomic_nervous0.90963517
112MP0001970_abnormal_pain_threshold0.90748182
113MP0003763_abnormal_thymus_physiology0.90146233
114MP0005084_abnormal_gallbladder_morpholo0.90007041
115MP0008775_abnormal_heart_ventricle0.89914132
116MP0005365_abnormal_bile_salt0.89289982
117MP0001529_abnormal_vocalization0.88375499
118MP0002557_abnormal_social/conspecific_i0.86923299
119MP0001929_abnormal_gametogenesis0.86650284
120MP0004215_abnormal_myocardial_fiber0.86510238
121MP0002733_abnormal_thermal_nociception0.85936522
122MP0002572_abnormal_emotion/affect_behav0.85825566
123MP0005195_abnormal_posterior_eye0.85588099
124MP0005174_abnormal_tail_pigmentation0.85517232
125MP0003283_abnormal_digestive_organ0.84631363
126MP0004924_abnormal_behavior0.83811419
127MP0005386_behavior/neurological_phenoty0.83811419
128MP0000538_abnormal_urinary_bladder0.81922469
129MP0003878_abnormal_ear_physiology0.81748322
130MP0005377_hearing/vestibular/ear_phenot0.81748322
131MP0002092_abnormal_eye_morphology0.81669312
132MP0000537_abnormal_urethra_morphology0.81133719
133MP0004145_abnormal_muscle_electrophysio0.81063958
134MP0009703_decreased_birth_body0.81008907
135MP0001764_abnormal_homeostasis0.80760372
136MP0002229_neurodegeneration0.79878836
137MP0002429_abnormal_blood_cell0.79800993
138MP0002095_abnormal_skin_pigmentation0.79768909
139MP0003252_abnormal_bile_duct0.79611401
140MP0002067_abnormal_sensory_capabilities0.79601265
141MP0001145_abnormal_male_reproductive0.79444760
142MP0002210_abnormal_sex_determination0.79267809
143MP0003950_abnormal_plasma_membrane0.78989872
144MP0003806_abnormal_nucleotide_metabolis0.78500804
145MP0002938_white_spotting0.78482186
146MP0002132_abnormal_respiratory_system0.78054410
147MP0001849_ear_inflammation0.78000247
148MP0003941_abnormal_skin_development0.77983331
149MP0004742_abnormal_vestibular_system0.77740419
150MP0001905_abnormal_dopamine_level0.77478551
151MP0005647_abnormal_sex_gland0.76758100
152MP0002234_abnormal_pharynx_morphology0.76488933
153MP0002138_abnormal_hepatobiliary_system0.75912811
154MP0009672_abnormal_birth_weight0.74662265
155MP0000049_abnormal_middle_ear0.74068519
156MP0001915_intracranial_hemorrhage0.73944060
157MP0004264_abnormal_extraembryonic_tissu0.73204586
158MP0003566_abnormal_cell_adhesion0.72722662
159MP0002697_abnormal_eye_size0.72555949
160MP0002925_abnormal_cardiovascular_devel0.72277448
161MP0001286_abnormal_eye_development0.71825505
162MP0000477_abnormal_intestine_morphology0.71689540
163MP0002075_abnormal_coat/hair_pigmentati0.70562168
164MP0000428_abnormal_craniofacial_morphol0.70514297
165MP0003315_abnormal_perineum_morphology0.69255611
166MP0000685_abnormal_immune_system0.68959678
167MP0005384_cellular_phenotype0.67452917
168MP0008770_decreased_survivor_rate0.67125833
169MP0003937_abnormal_limbs/digits/tail_de0.66587353
170MP0005075_abnormal_melanosome_morpholog0.65874749
171MP0002932_abnormal_joint_morphology0.65477970
172MP0009053_abnormal_anal_canal0.64515716
173MP0000716_abnormal_immune_system0.64015968
174MP0000432_abnormal_head_morphology0.63487425
175MP0003448_altered_tumor_morphology0.62794431
176MP0005621_abnormal_cell_physiology0.61535806
177MP0003787_abnormal_imprinting0.61214310
178MP0002114_abnormal_axial_skeleton0.60002659
179MP0000653_abnormal_sex_gland0.59964874
180MP0000358_abnormal_cell_content/0.58847357
181MP0002405_respiratory_system_inflammati0.58392335
182MP0001853_heart_inflammation0.57987194
183MP0001119_abnormal_female_reproductive0.57824678
184MP0003935_abnormal_craniofacial_develop0.56966901
185MP0000733_abnormal_muscle_development0.56708204
186MP0000371_diluted_coat_color0.56571044

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.79266683
2Chromsome breakage (HP:0040012)4.75581565
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.75020371
4Pancreatic cysts (HP:0001737)4.33725898
5Colon cancer (HP:0003003)3.99804028
6Pancreatic fibrosis (HP:0100732)3.99433843
7True hermaphroditism (HP:0010459)3.89539016
8Ependymoma (HP:0002888)3.72000505
9Congenital stationary night blindness (HP:0007642)3.64216039
10Medulloblastoma (HP:0002885)3.63285826
11Molar tooth sign on MRI (HP:0002419)3.56453186
12Abnormality of midbrain morphology (HP:0002418)3.56453186
13Nephronophthisis (HP:0000090)3.47469926
14Birth length less than 3rd percentile (HP:0003561)3.46931682
15Selective tooth agenesis (HP:0001592)3.46733963
16Abnormality of the renal cortex (HP:0011035)3.45186433
17Meckel diverticulum (HP:0002245)3.43845017
18Abnormality of the ileum (HP:0001549)3.39555092
19Abnormality of cells of the erythroid lineage (HP:0012130)3.22507791
20Aplasia/Hypoplasia of the uvula (HP:0010293)3.21775228
21Abnormality of chromosome stability (HP:0003220)3.19894115
22Abnormality of the renal medulla (HP:0100957)3.19840705
23Type II lissencephaly (HP:0007260)3.19013582
24Abnormal number of erythroid precursors (HP:0012131)3.07085018
25Abnormality of the preputium (HP:0100587)3.05361484
26Absent thumb (HP:0009777)2.96947497
27Abnormal number of incisors (HP:0011064)2.89006257
28Nephroblastoma (Wilms tumor) (HP:0002667)2.88471587
29Myelodysplasia (HP:0002863)2.87855173
30Medial flaring of the eyebrow (HP:0010747)2.83441068
31Small intestinal stenosis (HP:0012848)2.81460066
32Duodenal stenosis (HP:0100867)2.81460066
33Aplastic anemia (HP:0001915)2.78138821
34Renal cortical cysts (HP:0000803)2.77230197
35Attenuation of retinal blood vessels (HP:0007843)2.74354840
36Absent radius (HP:0003974)2.73763380
37Abolished electroretinogram (ERG) (HP:0000550)2.72220074
38Patellar aplasia (HP:0006443)2.72101351
39Rhabdomyosarcoma (HP:0002859)2.71537698
4011 pairs of ribs (HP:0000878)2.71497989
41Cystic liver disease (HP:0006706)2.68851978
42Oral leukoplakia (HP:0002745)2.67359350
43Agnosia (HP:0010524)2.66640552
44Embryonal renal neoplasm (HP:0011794)2.64925188
45Chronic hepatic failure (HP:0100626)2.64738892
46Pallor (HP:0000980)2.61528423
47Abnormality of B cell number (HP:0010975)2.61247854
48Missing ribs (HP:0000921)2.58862078
49Rib fusion (HP:0000902)2.57738326
50Hyperventilation (HP:0002883)2.55770765
51Duplicated collecting system (HP:0000081)2.55429175
52Abnormal drinking behavior (HP:0030082)2.54372691
53Polydipsia (HP:0001959)2.54372691
54Absent forearm bone (HP:0003953)2.53762621
55Aplasia involving forearm bones (HP:0009822)2.53762621
56Intestinal atresia (HP:0011100)2.53672645
57Breast hypoplasia (HP:0003187)2.52339179
58Ectopic kidney (HP:0000086)2.51799216
59Methylmalonic acidemia (HP:0002912)2.50085764
60Tubular atrophy (HP:0000092)2.48756482
61Abnormality of the astrocytes (HP:0100707)2.48246070
62Astrocytoma (HP:0009592)2.48246070
63Supernumerary spleens (HP:0009799)2.47777392
64Abnormal lung lobation (HP:0002101)2.46993737
65Gaze-evoked nystagmus (HP:0000640)2.46919491
66Abnormal rod and cone electroretinograms (HP:0008323)2.46764102
67Aplasia/Hypoplasia of the patella (HP:0006498)2.46188172
68Stomach cancer (HP:0012126)2.45750637
69Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.44684279
70Short 4th metacarpal (HP:0010044)2.44684279
71Abnormality of the duodenum (HP:0002246)2.42317370
72Basal cell carcinoma (HP:0002671)2.42240308
73Neoplasm of striated muscle (HP:0009728)2.40810588
74Asplenia (HP:0001746)2.39779047
75Tracheoesophageal fistula (HP:0002575)2.39550756
76Aplasia/Hypoplasia of the spleen (HP:0010451)2.37048023
77Increased nuchal translucency (HP:0010880)2.36918072
78Progressive inability to walk (HP:0002505)2.36038359
79Pendular nystagmus (HP:0012043)2.35755320
80Thyroiditis (HP:0100646)2.33002917
81Abnormality of the carotid arteries (HP:0005344)2.31309082
82Aplasia/Hypoplasia of the tibia (HP:0005772)2.31219642
83Cerebellar dysplasia (HP:0007033)2.30363180
84Neoplasm of the oral cavity (HP:0100649)2.29719599
85Sclerocornea (HP:0000647)2.28438072
86Bone marrow hypocellularity (HP:0005528)2.28315118
87Bile duct proliferation (HP:0001408)2.27956160
88Abnormal biliary tract physiology (HP:0012439)2.27956160
89Aplasia/Hypoplasia of the tongue (HP:0010295)2.27528527
90Atresia of the external auditory canal (HP:0000413)2.26621293
91Inability to walk (HP:0002540)2.24733691
92Polyuria (HP:0000103)2.24644818
93Hypoproteinemia (HP:0003075)2.24070711
94Aplasia/hypoplasia of the humerus (HP:0006507)2.22779329
95Impulsivity (HP:0100710)2.22771788
96Brushfield spots (HP:0001088)2.22368200
97Abnormality of the renal collecting system (HP:0004742)2.21353969
98Sloping forehead (HP:0000340)2.19354715
99Stomatitis (HP:0010280)2.18629343
100Methylmalonic aciduria (HP:0012120)2.18299802
101Increased CSF lactate (HP:0002490)2.17726699
102Broad-based gait (HP:0002136)2.17517436
103Absent rod-and cone-mediated responses on ERG (HP:0007688)2.17115055
104Abnormality of reticulocytes (HP:0004312)2.15207792
105Large for gestational age (HP:0001520)2.14964270
106Neoplasm of the pancreas (HP:0002894)2.14567256
107Increased corneal curvature (HP:0100692)2.14564562
108Keratoconus (HP:0000563)2.14564562
109Proximal placement of thumb (HP:0009623)2.13548750
110Lissencephaly (HP:0001339)2.13494245
111Furrowed tongue (HP:0000221)2.12098779
112Triphalangeal thumb (HP:0001199)2.12012589
113Deviation of the thumb (HP:0009603)2.11802458
114Macrocytic anemia (HP:0001972)2.11707949
115Glioma (HP:0009733)2.10995499
116Cafe-au-lait spot (HP:0000957)2.10612151
117Volvulus (HP:0002580)2.09824044
118Trismus (HP:0000211)2.09208422
119Congenital hepatic fibrosis (HP:0002612)2.08506884
120Duplication of thumb phalanx (HP:0009942)2.07391773
121Congenital primary aphakia (HP:0007707)2.06802339
122Gait imbalance (HP:0002141)2.06501679
123Short thumb (HP:0009778)2.06468804
124Mitochondrial inheritance (HP:0001427)2.04684300
125Short humerus (HP:0005792)2.04456266
126Postaxial foot polydactyly (HP:0001830)2.04356239
127Decreased electroretinogram (ERG) amplitude (HP:0000654)2.04290869
128Anencephaly (HP:0002323)2.03966355
129Abnormality of alanine metabolism (HP:0010916)2.03804658
130Hyperalaninemia (HP:0003348)2.03804658
131Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.03804658
132Premature graying of hair (HP:0002216)2.03245479
133Rough bone trabeculation (HP:0100670)2.02340196
134Multiple enchondromatosis (HP:0005701)2.02206289
135Aplasia/Hypoplasia of the sacrum (HP:0008517)2.01434354
136Hemiparesis (HP:0001269)2.00929562
137Rectovaginal fistula (HP:0000143)2.00633033
138Rectal fistula (HP:0100590)2.00633033
139Degeneration of anterior horn cells (HP:0002398)2.00121545
140Abnormality of the anterior horn cell (HP:0006802)2.00121545
141Decreased central vision (HP:0007663)1.99707829
142Abnormality of the labia minora (HP:0012880)1.98125532
143Abnormality of abdominal situs (HP:0011620)1.97497971
144Abdominal situs inversus (HP:0003363)1.97497971
145Hypothermia (HP:0002045)1.97323375
146Clubbing of toes (HP:0100760)1.97151960
147Febrile seizures (HP:0002373)1.96927487
148Squamous cell carcinoma (HP:0002860)1.96598621
149Male pseudohermaphroditism (HP:0000037)1.96307958
150Thrombocytosis (HP:0001894)1.96207718
1513-Methylglutaconic aciduria (HP:0003535)1.96186635
152IgG deficiency (HP:0004315)1.95466217
153Skin tags (HP:0010609)1.94276195
154Horseshoe kidney (HP:0000085)1.94157465
155Nephrogenic diabetes insipidus (HP:0009806)1.93248430
156Prominent nose (HP:0000448)1.92982436
157Preauricular skin tag (HP:0000384)1.92608883
158Genital tract atresia (HP:0001827)1.91419552
159Occipital encephalocele (HP:0002085)1.88322594
160Abnormality of pyrimidine metabolism (HP:0004353)1.87902885
161Supernumerary bones of the axial skeleton (HP:0009144)1.87627732
162Renal duplication (HP:0000075)1.87316259
163Chorioretinal atrophy (HP:0000533)1.86286114
164Optic nerve hypoplasia (HP:0000609)1.84875854
165Abnormality of DNA repair (HP:0003254)1.84036391
166Neoplasm of the colon (HP:0100273)1.83664046
167Hypomagnesemia (HP:0002917)1.83284006
168Carpal bone hypoplasia (HP:0001498)1.83160861
169Hypoplasia of the fovea (HP:0007750)1.83111190
170Aplasia/Hypoplasia of the fovea (HP:0008060)1.83111190
171Ketosis (HP:0001946)1.83082894
172Hepatocellular necrosis (HP:0001404)1.82599726
173Vaginal atresia (HP:0000148)1.82290317
174Aplasia/Hypoplasia of the sternum (HP:0006714)1.82256560
175Short tibia (HP:0005736)1.82170233
176Intestinal fistula (HP:0100819)1.81999013
177Fair hair (HP:0002286)1.80648083
178Amaurosis fugax (HP:0100576)1.80259782
179Microretrognathia (HP:0000308)1.80241350
180Acute necrotizing encephalopathy (HP:0006965)1.79426162
181Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79009231
182Postaxial hand polydactyly (HP:0001162)1.78618199
183Hepatic necrosis (HP:0002605)1.77506222
184Abnormal urine output (HP:0012590)1.77168550
185Absent speech (HP:0001344)1.76044794
186Disproportionate short-trunk short stature (HP:0003521)1.75855882
187Abnormality of the pons (HP:0007361)1.73890109
188Hypoplasia of the pons (HP:0012110)1.73789046
189Lipid accumulation in hepatocytes (HP:0006561)1.71733656
190Severe combined immunodeficiency (HP:0004430)1.70460983
191Bony spicule pigmentary retinopathy (HP:0007737)1.70122938
192Congenital, generalized hypertrichosis (HP:0004540)1.69836853
193Ketoacidosis (HP:0001993)1.68861233

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.42179651
2CDC74.77194732
3WEE14.13365259
4BUB13.50392656
5CDK123.33797092
6MAP4K23.19369024
7BMPR1B3.18374567
8NUAK12.98570401
9NEK22.94520731
10ADRBK22.87768876
11TTK2.56370680
12NEK12.54774526
13PINK12.37526328
14PKN22.36532249
15EIF2AK12.35308589
16CDK72.32567795
17WNK32.32313836
18PASK2.27405309
19EEF2K2.24513855
20INSRR2.19220846
21PLK12.09036570
22SRPK12.02078978
23TRIM281.95393709
24RPS6KB21.95332867
25TAOK31.87701729
26MAP3K101.87692720
27ATR1.87116026
28TLK11.85113356
29STK101.73920436
30BRSK21.69670514
31AURKB1.69295894
32TSSK61.64859628
33TXK1.63413222
34CHEK21.62234539
35MAPK131.58252422
36FLT31.57926355
37MAP3K41.57347509
38CDK41.50890809
39TGFBR11.50819933
40ACVR1B1.50198662
41MAP3K81.49783385
42WNK41.48538000
43NME21.47503712
44VRK11.46015041
45BCKDK1.37471521
46MST41.35901213
47MKNK11.34996868
48CHEK11.32866130
49PLK31.30728902
50CSNK1G11.30428668
51PLK21.30413862
52TESK21.29710361
53OXSR11.29176225
54STK41.28940421
55PAK41.24515669
56GRK61.23646813
57CSNK1G31.20779273
58STK391.17770475
59STK38L1.17541615
60VRK21.16664022
61SCYL21.16283819
62CASK1.15901045
63ITK1.14165604
64AURKA1.13570300
65BRD41.11778505
66PIM11.08016874
67FGFR21.07965154
68CSNK1G21.07042045
69CSNK1A1L1.04865896
70LRRK21.04037374
71BRSK11.04031773
72PLK41.03965202
73BCR1.03378048
74MAP2K71.00539268
75PAK31.00076357
76DYRK30.99032907
77ATM0.98926169
78EPHA20.98840349
79ADRBK10.98728560
80RPS6KA40.98410369
81CDK60.98196290
82PRKCE0.97503552
83DYRK20.94498616
84MAP4K10.93671658
85CLK10.93193684
86CAMKK20.91790007
87CDK20.91713431
88ALK0.91286452
89CCNB10.89172502
90DAPK20.85953315
91ERBB30.82952207
92CDK80.78286674
93LATS10.77319453
94MAP2K30.77298560
95ICK0.74364316
96PHKG20.73289106
97PHKG10.73289106
98EIF2AK30.72222471
99IKBKB0.72019993
100PRKCG0.71267737
101IRAK10.70835335
102PTK2B0.70543137
103NLK0.68219318
104CDK10.65661762
105PKN10.63239563
106MUSK0.62012251
107MKNK20.61982624
108BTK0.61816016
109PRKCQ0.61739036
110MTOR0.60917282
111PRKCI0.60771196
112MAPKAPK30.60685831
113BMX0.60569373
114TNIK0.60543715
115PAK10.60514122
116EIF2AK20.60127706
117CSNK2A20.59731969
118PIK3CG0.59383902
119CSNK2A10.56985633
120CAMKK10.56172462
121MAP3K110.55963486
122TRIB30.54642250
123MELK0.54346706
124CSF1R0.52894236
125AKT20.51917136
126KDR0.51865855
127CSNK1A10.51562196
128MATK0.48881168
129EPHA40.48584444
130TEC0.48356232
131STK160.47266467
132TAF10.47174295
133GRK50.47157750
134PIM20.46890119
135OBSCN0.46533598
136CHUK0.46485711
137TNK20.46303871
138MAP3K130.43977584
139PAK20.42943830
140PNCK0.41425673
141CAMK2A0.41386115
142RPS6KA50.41068688
143CSNK1D0.40434043
144MARK10.39345596
145CAMK10.39117981
146AKT30.38835560
147GRK10.38264807
148NTRK30.38223725
149MAP2K60.38005851
150CDK30.37617904
151ZAK0.37032099
152STK30.36906465
153PRKDC0.36853478
154YES10.35853391
155PRKACA0.35777773
156MAPKAPK50.34801775
157TTN0.34484135
158AKT10.33391544
159PRKAA20.32531763
160PRKCA0.32307479
161NME10.32219121
162TIE10.31737358
163TAOK20.30359361
164TESK10.29299458
165DAPK10.29264664
166FGFR10.29097380
167MAPK140.28850635
168RPS6KL10.28783729
169RPS6KC10.28783729
170MAPK10.27305994
171RPS6KA10.26617445
172DYRK1B0.26580927
173KIT0.24131809
174RPS6KA60.24045203

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.62350183
2Mismatch repair_Homo sapiens_hsa034304.94298132
3Base excision repair_Homo sapiens_hsa034103.44984867
4Ribosome_Homo sapiens_hsa030103.36098812
5Homologous recombination_Homo sapiens_hsa034403.24455052
6Spliceosome_Homo sapiens_hsa030403.17470050
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.08574519
8One carbon pool by folate_Homo sapiens_hsa006703.06420617
9Cell cycle_Homo sapiens_hsa041102.99089448
10Nucleotide excision repair_Homo sapiens_hsa034202.89441718
11RNA transport_Homo sapiens_hsa030132.82094516
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.75032331
13Fanconi anemia pathway_Homo sapiens_hsa034602.57647920
14Butanoate metabolism_Homo sapiens_hsa006502.53892037
15Phototransduction_Homo sapiens_hsa047442.45308678
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.40923779
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.33660522
18RNA polymerase_Homo sapiens_hsa030202.32737999
19Nitrogen metabolism_Homo sapiens_hsa009102.26425413
20Linoleic acid metabolism_Homo sapiens_hsa005912.19479949
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.18189600
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.15931384
23Pyrimidine metabolism_Homo sapiens_hsa002402.14968275
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.01630184
25Non-homologous end-joining_Homo sapiens_hsa034501.98704746
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.96745270
27Protein export_Homo sapiens_hsa030601.95280140
28Oxidative phosphorylation_Homo sapiens_hsa001901.93127498
29p53 signaling pathway_Homo sapiens_hsa041151.87427786
30mRNA surveillance pathway_Homo sapiens_hsa030151.84355574
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.83482153
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83267998
33Caffeine metabolism_Homo sapiens_hsa002321.82673754
34Proteasome_Homo sapiens_hsa030501.81016080
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.80805372
36Tryptophan metabolism_Homo sapiens_hsa003801.80709540
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.71586503
38Propanoate metabolism_Homo sapiens_hsa006401.69618255
39RNA degradation_Homo sapiens_hsa030181.67742687
40Ether lipid metabolism_Homo sapiens_hsa005651.63462614
41Nicotine addiction_Homo sapiens_hsa050331.61441047
42Peroxisome_Homo sapiens_hsa041461.56895666
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.45036353
44Parkinsons disease_Homo sapiens_hsa050121.41429883
45Systemic lupus erythematosus_Homo sapiens_hsa053221.29575477
46Olfactory transduction_Homo sapiens_hsa047401.28720815
47Basal transcription factors_Homo sapiens_hsa030221.26520130
48Taste transduction_Homo sapiens_hsa047421.26092921
49Intestinal immune network for IgA production_Homo sapiens_hsa046721.24171928
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19370837
51Primary bile acid biosynthesis_Homo sapiens_hsa001201.18109125
52Steroid hormone biosynthesis_Homo sapiens_hsa001401.16290168
53Retinol metabolism_Homo sapiens_hsa008301.13020551
54Regulation of autophagy_Homo sapiens_hsa041401.12169783
55Chemical carcinogenesis_Homo sapiens_hsa052041.10278403
56Viral carcinogenesis_Homo sapiens_hsa052031.08109897
57ABC transporters_Homo sapiens_hsa020101.05301716
58Epstein-Barr virus infection_Homo sapiens_hsa051691.02718480
59Type I diabetes mellitus_Homo sapiens_hsa049401.02077799
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01870920
61Herpes simplex infection_Homo sapiens_hsa051680.99562067
62Arachidonic acid metabolism_Homo sapiens_hsa005900.98482566
63Collecting duct acid secretion_Homo sapiens_hsa049660.98323094
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98172415
65Purine metabolism_Homo sapiens_hsa002300.96586411
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96232456
67MicroRNAs in cancer_Homo sapiens_hsa052060.95603259
68Huntingtons disease_Homo sapiens_hsa050160.91388248
69Selenocompound metabolism_Homo sapiens_hsa004500.91274130
70Morphine addiction_Homo sapiens_hsa050320.90508566
71Oocyte meiosis_Homo sapiens_hsa041140.89553981
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88984975
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87629096
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86979373
75HTLV-I infection_Homo sapiens_hsa051660.86013708
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85875784
77Biosynthesis of amino acids_Homo sapiens_hsa012300.85006101
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84727960
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83158836
80Antigen processing and presentation_Homo sapiens_hsa046120.81448814
81Graft-versus-host disease_Homo sapiens_hsa053320.80129319
82Small cell lung cancer_Homo sapiens_hsa052220.79605059
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78426371
84Alzheimers disease_Homo sapiens_hsa050100.77215403
85Autoimmune thyroid disease_Homo sapiens_hsa053200.76092809
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71151117
87Metabolic pathways_Homo sapiens_hsa011000.70858483
88Asthma_Homo sapiens_hsa053100.69674363
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69563362
90Notch signaling pathway_Homo sapiens_hsa043300.69444858
91Allograft rejection_Homo sapiens_hsa053300.68598911
92Insulin secretion_Homo sapiens_hsa049110.67481353
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66440114
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65090324
95Cardiac muscle contraction_Homo sapiens_hsa042600.64977704
96Legionellosis_Homo sapiens_hsa051340.64889191
97Glycerolipid metabolism_Homo sapiens_hsa005610.64870654
98Primary immunodeficiency_Homo sapiens_hsa053400.64734287
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63993106
100Thyroid cancer_Homo sapiens_hsa052160.63780125
101Pentose phosphate pathway_Homo sapiens_hsa000300.63305527
102Basal cell carcinoma_Homo sapiens_hsa052170.62798976
103Serotonergic synapse_Homo sapiens_hsa047260.61989313
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.60485139
105Folate biosynthesis_Homo sapiens_hsa007900.60401199
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59662223
107beta-Alanine metabolism_Homo sapiens_hsa004100.58491208
108Chronic myeloid leukemia_Homo sapiens_hsa052200.58229461
109GABAergic synapse_Homo sapiens_hsa047270.57810318
110Ovarian steroidogenesis_Homo sapiens_hsa049130.57684248
111Calcium signaling pathway_Homo sapiens_hsa040200.56531018
112Colorectal cancer_Homo sapiens_hsa052100.56177754
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55894958
114Cysteine and methionine metabolism_Homo sapiens_hsa002700.55244662
115Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53564778
116Bladder cancer_Homo sapiens_hsa052190.53421032
117Apoptosis_Homo sapiens_hsa042100.52767472
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.52252297
119Glutamatergic synapse_Homo sapiens_hsa047240.51762126
120TGF-beta signaling pathway_Homo sapiens_hsa043500.51664684
121Circadian entrainment_Homo sapiens_hsa047130.51634032
122Sulfur metabolism_Homo sapiens_hsa009200.51266564
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51065336
124Hippo signaling pathway_Homo sapiens_hsa043900.50533321
125Fatty acid degradation_Homo sapiens_hsa000710.49965328
126Fatty acid elongation_Homo sapiens_hsa000620.49888240
127Alcoholism_Homo sapiens_hsa050340.49624680
128Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49569572
129Salivary secretion_Homo sapiens_hsa049700.47872700
130Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47552602
131mTOR signaling pathway_Homo sapiens_hsa041500.46322268
132Fat digestion and absorption_Homo sapiens_hsa049750.45563870
133Hepatitis B_Homo sapiens_hsa051610.45405660
134Measles_Homo sapiens_hsa051620.44859410
135HIF-1 signaling pathway_Homo sapiens_hsa040660.44164738
136Pathways in cancer_Homo sapiens_hsa052000.44162203
137Rheumatoid arthritis_Homo sapiens_hsa053230.43660145
138Acute myeloid leukemia_Homo sapiens_hsa052210.43184504
139Drug metabolism - other enzymes_Homo sapiens_hsa009830.42680794
140Circadian rhythm_Homo sapiens_hsa047100.42177060
141Shigellosis_Homo sapiens_hsa051310.41334891
142Mineral absorption_Homo sapiens_hsa049780.40834914
143Fatty acid metabolism_Homo sapiens_hsa012120.39395606
144Fructose and mannose metabolism_Homo sapiens_hsa000510.38944202
145Adherens junction_Homo sapiens_hsa045200.38248209
146Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37849124
147Viral myocarditis_Homo sapiens_hsa054160.36339131
148Sulfur relay system_Homo sapiens_hsa041220.35946429
149Steroid biosynthesis_Homo sapiens_hsa001000.35828759
150Lysine degradation_Homo sapiens_hsa003100.34964335
151NF-kappa B signaling pathway_Homo sapiens_hsa040640.32725787
152Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32571832
153Melanoma_Homo sapiens_hsa052180.32462764
154Non-small cell lung cancer_Homo sapiens_hsa052230.32345895
155Hedgehog signaling pathway_Homo sapiens_hsa043400.31576787
156Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31503556
157Prostate cancer_Homo sapiens_hsa052150.31292979
158Carbon metabolism_Homo sapiens_hsa012000.31031782
159Galactose metabolism_Homo sapiens_hsa000520.30983088
1602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27872566
161Influenza A_Homo sapiens_hsa051640.26987260
162Hematopoietic cell lineage_Homo sapiens_hsa046400.25240746
163Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24773159
164Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24724884
165Proteoglycans in cancer_Homo sapiens_hsa052050.24078618
166Pancreatic cancer_Homo sapiens_hsa052120.23814910
167Glutathione metabolism_Homo sapiens_hsa004800.23511350
168PI3K-Akt signaling pathway_Homo sapiens_hsa041510.22134806
169Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.21861168
170N-Glycan biosynthesis_Homo sapiens_hsa005100.21349595
171Leishmaniasis_Homo sapiens_hsa051400.21346485
172Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.21165989
173Leukocyte transendothelial migration_Homo sapiens_hsa046700.19817341
174NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18645873
175Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.16545875
176Jak-STAT signaling pathway_Homo sapiens_hsa046300.15114505
177Wnt signaling pathway_Homo sapiens_hsa043100.15008490
178B cell receptor signaling pathway_Homo sapiens_hsa046620.14224284
179Regulation of actin cytoskeleton_Homo sapiens_hsa048100.13650293
180Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.13038345

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