XKR6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.53050943
2positive regulation of action potential (GO:0045760)5.42608779
3neuron cell-cell adhesion (GO:0007158)5.03486985
4presynaptic membrane assembly (GO:0097105)4.38242098
5pyrimidine nucleobase catabolic process (GO:0006208)4.18755422
6righting reflex (GO:0060013)4.09602715
7presynaptic membrane organization (GO:0097090)3.91125656
8detection of calcium ion (GO:0005513)3.89985629
9postsynaptic membrane organization (GO:0001941)3.88388746
10positive regulation of synaptic transmission, GABAergic (GO:0032230)3.84917265
11auditory behavior (GO:0031223)3.84709058
12negative regulation of transcription regulatory region DNA binding (GO:2000678)3.73166875
13protein targeting to Golgi (GO:0000042)3.69345109
14negative regulation of translation, ncRNA-mediated (GO:0040033)3.66229309
15regulation of translation, ncRNA-mediated (GO:0045974)3.66229309
16negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.66229309
17regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.59925612
18single strand break repair (GO:0000012)3.52214487
19retinal ganglion cell axon guidance (GO:0031290)3.47300100
20vocalization behavior (GO:0071625)3.45382849
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.38439320
22negative regulation of neurotransmitter transport (GO:0051589)3.32600071
23regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.30738975
24regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.30020451
25nonmotile primary cilium assembly (GO:0035058)3.27549114
26establishment of protein localization to Golgi (GO:0072600)3.27372438
27negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.27128528
28retina layer formation (GO:0010842)3.24954853
29olfactory bulb development (GO:0021772)3.22843961
30neuron recognition (GO:0008038)3.22767731
31neurotransmitter-gated ion channel clustering (GO:0072578)3.22505163
32nucleobase catabolic process (GO:0046113)3.22357087
33negative regulation of neurotransmitter secretion (GO:0046929)3.22150564
34epithelial cilium movement (GO:0003351)3.20621716
35neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.17855220
36startle response (GO:0001964)3.17621828
37cell proliferation in forebrain (GO:0021846)3.16766232
38regulation of synaptic vesicle exocytosis (GO:2000300)3.14698374
39DNA double-strand break processing (GO:0000729)3.14603727
40regulation of short-term neuronal synaptic plasticity (GO:0048172)3.14322100
41regulation of timing of cell differentiation (GO:0048505)3.13569716
42cranial nerve development (GO:0021545)3.11351030
43cerebellar Purkinje cell differentiation (GO:0021702)3.11284394
44synaptic transmission, cholinergic (GO:0007271)3.10621261
45retrograde transport, vesicle recycling within Golgi (GO:0000301)3.10137728
46metanephric mesenchyme development (GO:0072075)3.08300017
47seminiferous tubule development (GO:0072520)3.06728049
48neural tube formation (GO:0001841)3.06425668
49regulation of respiratory system process (GO:0044065)3.06068670
50positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.06040469
51behavioral response to ethanol (GO:0048149)3.05776197
52regulation of action potential (GO:0098900)3.05180346
53regulation of vesicle fusion (GO:0031338)3.05130637
54regulation of synaptic transmission, GABAergic (GO:0032228)3.04535299
55protein localization to synapse (GO:0035418)3.04274725
56G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.02757030
57neuron-neuron synaptic transmission (GO:0007270)3.01389239
58glutamate receptor signaling pathway (GO:0007215)3.00782563
59regulation of respiratory gaseous exchange (GO:0043576)3.00686616
60positive regulation of synapse assembly (GO:0051965)2.99925401
61regulation of telomere maintenance (GO:0032204)2.99528497
62keratinocyte development (GO:0003334)2.99228591
63sympathetic nervous system development (GO:0048485)2.98583519
64synaptic transmission, glutamatergic (GO:0035249)2.97638772
65kidney mesenchyme development (GO:0072074)2.97340742
66tachykinin receptor signaling pathway (GO:0007217)2.96850461
67regulation of cilium movement (GO:0003352)2.96401109
68gamma-aminobutyric acid signaling pathway (GO:0007214)2.95640054
69innervation (GO:0060384)2.95430553
70transmission of nerve impulse (GO:0019226)2.95257072
71ionotropic glutamate receptor signaling pathway (GO:0035235)2.94916406
72cilium or flagellum-dependent cell motility (GO:0001539)2.94001089
73neuronal action potential propagation (GO:0019227)2.93970102
74head development (GO:0060322)2.92741910
75regulation of gene silencing by RNA (GO:0060966)2.92573632
76regulation of posttranscriptional gene silencing (GO:0060147)2.92573632
77regulation of gene silencing by miRNA (GO:0060964)2.92573632
78central nervous system projection neuron axonogenesis (GO:0021952)2.91905627
79regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.87928133
80regulation of glutamate receptor signaling pathway (GO:1900449)2.87403368
81positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.86540524
82regulation of synapse assembly (GO:0051963)2.84469211
83spinal cord motor neuron differentiation (GO:0021522)2.83295051
84regulation of synaptic vesicle transport (GO:1902803)2.80914207
85inner ear receptor cell development (GO:0060119)2.80461904
86somite development (GO:0061053)2.79495220
87endocrine pancreas development (GO:0031018)2.78622645
88gamma-aminobutyric acid transport (GO:0015812)2.77611983
89forebrain neuron differentiation (GO:0021879)2.77427012
90neuronal action potential (GO:0019228)2.77348612
91otic vesicle formation (GO:0030916)2.74738346
92dendritic spine morphogenesis (GO:0060997)2.74150299
93regulation of development, heterochronic (GO:0040034)2.73716630
94mechanosensory behavior (GO:0007638)2.73688895
95response to pheromone (GO:0019236)2.73545131
96axonal fasciculation (GO:0007413)2.73528632
97cornea development in camera-type eye (GO:0061303)2.71360502
98protein polyglutamylation (GO:0018095)2.71316210
99positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.71225520
100cranial nerve morphogenesis (GO:0021602)2.70913319
101protein localization to Golgi apparatus (GO:0034067)2.70473532
102intraciliary transport (GO:0042073)2.69822719
103mating behavior (GO:0007617)2.69765008
104negative regulation of membrane potential (GO:0045837)2.69506189
105cell migration in hindbrain (GO:0021535)2.69344578
106kidney morphogenesis (GO:0060993)2.67613841
107positive regulation of dendritic spine morphogenesis (GO:0061003)2.67605840
108cilium movement (GO:0003341)2.67175845
109synapse assembly (GO:0007416)2.66621198
110establishment of mitochondrion localization (GO:0051654)2.65806644
111layer formation in cerebral cortex (GO:0021819)2.64882594
112neuromuscular synaptic transmission (GO:0007274)2.64557395
113regulation of microtubule-based movement (GO:0060632)2.64005300
114adult walking behavior (GO:0007628)2.62955250
115calcium ion import (GO:0070509)2.62737111
116epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.60652192
117tongue development (GO:0043586)2.60004777
118cerebral cortex radially oriented cell migration (GO:0021799)2.59008110
119cochlea development (GO:0090102)2.58664627
120catecholamine transport (GO:0051937)2.58112500
121regulation of collateral sprouting (GO:0048670)2.58082953
122water-soluble vitamin biosynthetic process (GO:0042364)2.57810004
123regulation of calcium ion-dependent exocytosis (GO:0017158)2.57652068
124response to auditory stimulus (GO:0010996)2.56956700
125replication fork processing (GO:0031297)2.56448097
126limb bud formation (GO:0060174)2.56307104
127negative regulation of telomere maintenance (GO:0032205)2.56181581
128glandular epithelial cell differentiation (GO:0002067)2.55388552
129C4-dicarboxylate transport (GO:0015740)2.54106082
130protein neddylation (GO:0045116)2.54036200
131cell differentiation in hindbrain (GO:0021533)2.53859621
132axon ensheathment in central nervous system (GO:0032291)2.53457290
133central nervous system myelination (GO:0022010)2.53457290
134urinary tract smooth muscle contraction (GO:0014848)2.53284337
135regulation of synaptic transmission, glutamatergic (GO:0051966)2.52837787
136locomotory exploration behavior (GO:0035641)2.52773210
137synaptic vesicle exocytosis (GO:0016079)2.52311237
138insulin secretion (GO:0030073)2.52113896
139fear response (GO:0042596)2.52087185
140dendrite development (GO:0016358)2.50825572
141sequestering of actin monomers (GO:0042989)2.49887460
142regulation of cAMP-dependent protein kinase activity (GO:2000479)2.49035453
143cilium morphogenesis (GO:0060271)2.48078526
144membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.47625058
145mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.46951730
146regulation of catecholamine metabolic process (GO:0042069)2.46606505
147regulation of dopamine metabolic process (GO:0042053)2.46606505
148hindbrain development (GO:0030902)2.46510681
149establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.45510881
150mitochondrion transport along microtubule (GO:0047497)2.45510881
151detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.45245548
152positive regulation of amino acid transport (GO:0051957)2.45159151
153behavioral defense response (GO:0002209)2.44945097
154behavioral fear response (GO:0001662)2.44945097
155retinal cone cell development (GO:0046549)2.44063484
156membrane hyperpolarization (GO:0060081)2.43993131
157spinal cord development (GO:0021510)2.43776572
158regulation of feeding behavior (GO:0060259)2.43200986
159limb development (GO:0060173)2.42677271
160appendage development (GO:0048736)2.42677271
161cilium organization (GO:0044782)2.42403266
162negative regulation of astrocyte differentiation (GO:0048712)2.42310819
163calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.41837666
164somatic diversification of immune receptors via somatic mutation (GO:0002566)2.39110382
165somatic hypermutation of immunoglobulin genes (GO:0016446)2.39110382
166cilium assembly (GO:0042384)2.37608542
167photoreceptor cell maintenance (GO:0045494)2.35404050
168membrane depolarization during action potential (GO:0086010)2.34239775
169regulation of rhodopsin mediated signaling pathway (GO:0022400)2.34182404
170negative regulation of axon guidance (GO:1902668)2.34164124
171photoreceptor cell development (GO:0042461)2.33750044

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.64859355
2GBX2_23144817_ChIP-Seq_PC3_Human4.43126928
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.85772234
4EZH2_27304074_Chip-Seq_ESCs_Mouse2.56349512
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.52215248
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.51280419
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.44583252
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.43937325
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.43858190
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19977226
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.16948936
12* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.15549361
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.13219762
14REST_21632747_ChIP-Seq_MESCs_Mouse2.07253971
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05367744
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04864135
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.02770378
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.01579783
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.01579783
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00872204
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98530045
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.98504426
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.96724225
24TAF15_26573619_Chip-Seq_HEK293_Human1.90435691
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.88872682
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.87943573
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83540653
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.82914298
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.82855210
30MTF2_20144788_ChIP-Seq_MESCs_Mouse1.80350104
31FUS_26573619_Chip-Seq_HEK293_Human1.79653536
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79370063
33P300_19829295_ChIP-Seq_ESCs_Human1.78923273
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.77348388
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.75833566
36DROSHA_22980978_ChIP-Seq_HELA_Human1.70066974
37RNF2_27304074_Chip-Seq_NSC_Mouse1.69277376
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69125264
39SMAD4_21799915_ChIP-Seq_A2780_Human1.68725947
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.68312790
41IGF1R_20145208_ChIP-Seq_DFB_Human1.68099175
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67314290
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66701900
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63451787
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.62996224
46ZNF274_21170338_ChIP-Seq_K562_Hela1.59195330
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.57758887
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.54410215
49* STAT3_23295773_ChIP-Seq_U87_Human1.51545230
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49510792
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48010467
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47903910
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47783340
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45528021
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.44739493
56BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43648990
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41333032
58IRF1_19129219_ChIP-ChIP_H3396_Human1.41244454
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39930458
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39528315
61* REST_18959480_ChIP-ChIP_MESCs_Mouse1.39495512
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.39199739
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.37192143
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35308090
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35308090
66MYC_18940864_ChIP-ChIP_HL60_Human1.35269036
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33773119
68IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31134904
69VDR_22108803_ChIP-Seq_LS180_Human1.29337550
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28859943
71* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28368240
72* TCF4_23295773_ChIP-Seq_U87_Human1.26904338
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26854560
74SOX2_21211035_ChIP-Seq_LN229_Gbm1.26180197
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25703522
76CBP_20019798_ChIP-Seq_JUKART_Human1.25703522
77BCAT_22108803_ChIP-Seq_LS180_Human1.25598386
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24439816
79AR_25329375_ChIP-Seq_VCAP_Human1.23871051
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23836900
81RUNX2_22187159_ChIP-Seq_PCA_Human1.23055299
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22619563
83EWS_26573619_Chip-Seq_HEK293_Human1.21917565
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21699778
85RARB_27405468_Chip-Seq_BRAIN_Mouse1.20331036
86JUN_21703547_ChIP-Seq_K562_Human1.19892953
87ER_23166858_ChIP-Seq_MCF-7_Human1.19808264
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18630395
89* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17409280
90AR_21572438_ChIP-Seq_LNCaP_Human1.16930623
91E2F1_18555785_Chip-Seq_ESCs_Mouse1.16166091
92ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15802647
93TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15312072
94RING1B_27294783_Chip-Seq_ESCs_Mouse1.13990702
95RING1B_27294783_Chip-Seq_NPCs_Mouse1.13869550
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13762143
97* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12509098
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12034150
99TAL1_26923725_Chip-Seq_HPCs_Mouse1.11896951
100P53_22387025_ChIP-Seq_ESCs_Mouse1.11582912
101PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10641559
102TP53_16413492_ChIP-PET_HCT116_Human1.10070659
103ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09445446
104TP63_19390658_ChIP-ChIP_HaCaT_Human1.09033861
105STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08921843
106KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08796767
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08532276
108CMYC_18555785_Chip-Seq_ESCs_Mouse1.07921620
109* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07514467
110TCF4_22108803_ChIP-Seq_LS180_Human1.06907824
111EST1_17652178_ChIP-ChIP_JURKAT_Human1.06441218
112* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06409154
113ARNT_22903824_ChIP-Seq_MCF-7_Human1.05651881
114SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05185351
115FLI1_21867929_ChIP-Seq_TH2_Mouse1.05003617
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04957450
117* AR_19668381_ChIP-Seq_PC3_Human1.04239343
118* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02574403
119SALL1_21062744_ChIP-ChIP_HESCs_Human1.02459912
120TP53_22573176_ChIP-Seq_HFKS_Human1.02286808
121P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99250967
122* PRDM14_20953172_ChIP-Seq_ESCs_Human0.98637388
123SOX2_16153702_ChIP-ChIP_HESCs_Human0.98273131
124RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95870955

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo3.54470915
2MP0003880_abnormal_central_pattern3.17208941
3MP0003183_abnormal_peptide_metabolism2.88346573
4MP0006072_abnormal_retinal_apoptosis2.80997542
5MP0001188_hyperpigmentation2.78355762
6MP0005645_abnormal_hypothalamus_physiol2.48800103
7MP0003635_abnormal_synaptic_transmissio2.39793177
8MP0004270_analgesia2.39230129
9MP0009046_muscle_twitch2.28025056
10MP0008877_abnormal_DNA_methylation2.15314622
11MP0001486_abnormal_startle_reflex2.14318061
12MP0000566_synostosis2.10442606
13MP0004043_abnormal_pH_regulation2.10242246
14MP0009745_abnormal_behavioral_response2.09124166
15MP0005423_abnormal_somatic_nervous2.08081366
16MP0006276_abnormal_autonomic_nervous2.07394379
17MP0010386_abnormal_urinary_bladder2.06327243
18MP0000013_abnormal_adipose_tissue2.03923792
19MP0000778_abnormal_nervous_system1.98353463
20MP0002653_abnormal_ependyma_morphology1.97996617
21MP0004859_abnormal_synaptic_plasticity1.97310095
22MP0006292_abnormal_olfactory_placode1.96804904
23MP0002572_abnormal_emotion/affect_behav1.96122334
24MP0008789_abnormal_olfactory_epithelium1.95736521
25MP0002063_abnormal_learning/memory/cond1.92840675
26MP0002184_abnormal_innervation1.91584818
27MP0003122_maternal_imprinting1.90345985
28MP0002734_abnormal_mechanical_nocicepti1.89002790
29MP0001293_anophthalmia1.86864160
30MP0003787_abnormal_imprinting1.84072672
31MP0005379_endocrine/exocrine_gland_phen1.81819301
32MP0001529_abnormal_vocalization1.81552700
33MP0000631_abnormal_neuroendocrine_gland1.80030338
34MP0002064_seizures1.79235745
35MP0002272_abnormal_nervous_system1.77826935
36MP0001968_abnormal_touch/_nociception1.69437393
37MP0005551_abnormal_eye_electrophysiolog1.69359775
38MP0002557_abnormal_social/conspecific_i1.66646933
39MP0002234_abnormal_pharynx_morphology1.64937105
40MP0000372_irregular_coat_pigmentation1.63456647
41MP0001440_abnormal_grooming_behavior1.55635920
42MP0002733_abnormal_thermal_nociception1.54604873
43MP0002067_abnormal_sensory_capabilities1.53664119
44MP0003283_abnormal_digestive_organ1.53612682
45MP0005646_abnormal_pituitary_gland1.53248714
46MP0002102_abnormal_ear_morphology1.46798642
47MP0002909_abnormal_adrenal_gland1.46667611
48MP0005253_abnormal_eye_physiology1.45178688
49MP0002735_abnormal_chemical_nociception1.44647491
50MP0002751_abnormal_autonomic_nervous1.41718566
51MP0004142_abnormal_muscle_tone1.40973476
52MP0000569_abnormal_digit_pigmentation1.40153043
53MP0001502_abnormal_circadian_rhythm1.37465976
54MP0002638_abnormal_pupillary_reflex1.36312077
55MP0001970_abnormal_pain_threshold1.31035745
56MP0003136_yellow_coat_color1.30826518
57MP0003646_muscle_fatigue1.29597882
58MP0000955_abnormal_spinal_cord1.28869688
59MP0004742_abnormal_vestibular_system1.28598387
60MP0001501_abnormal_sleep_pattern1.28459787
61MP0003119_abnormal_digestive_system1.28442055
62MP0002693_abnormal_pancreas_physiology1.28434740
63MP0001944_abnormal_pancreas_morphology1.27744549
64MP0001984_abnormal_olfaction1.25752691
65MP0003890_abnormal_embryonic-extraembry1.24594271
66MP0001905_abnormal_dopamine_level1.23621705
67MP0001485_abnormal_pinna_reflex1.23091766
68MP0005386_behavior/neurological_phenoty1.21058604
69MP0004924_abnormal_behavior1.21058604
70MP0002882_abnormal_neuron_morphology1.20334694
71MP0002736_abnormal_nociception_after1.18085200
72MP0002837_dystrophic_cardiac_calcinosis1.17026736
73MP0004145_abnormal_muscle_electrophysio1.13745313
74MP0008058_abnormal_DNA_repair1.12986703
75MP0008872_abnormal_physiological_respon1.12371026
76MP0000678_abnormal_parathyroid_gland1.10796124
77MP0002233_abnormal_nose_morphology1.09355893
78MP0002938_white_spotting1.08104849
79MP0001986_abnormal_taste_sensitivity1.07951596
80MP0000427_abnormal_hair_cycle1.07133513
81MP0001286_abnormal_eye_development1.02336140
82MP0002152_abnormal_brain_morphology1.01928189
83MP0002752_abnormal_somatic_nervous1.01326636
84MP0000462_abnormal_digestive_system1.00574772
85MP0002066_abnormal_motor_capabilities/c1.00416875
86MP0004885_abnormal_endolymph1.00416854
87MP0008057_abnormal_DNA_replication1.00175116
88MP0005248_abnormal_Harderian_gland0.99144542
89MP0003315_abnormal_perineum_morphology0.98122850
90MP0005409_darkened_coat_color0.98033137
91MP0001919_abnormal_reproductive_system0.97898383
92MP0001963_abnormal_hearing_physiology0.97812278
93MP0009379_abnormal_foot_pigmentation0.97764393
94MP0004133_heterotaxia0.96975233
95MP0003567_abnormal_fetal_cardiomyocyte0.96933083
96MP0003121_genomic_imprinting0.95826981
97MP0000026_abnormal_inner_ear0.95731325
98MP0005171_absent_coat_pigmentation0.94485341
99MP0003879_abnormal_hair_cell0.93457849
100MP0000049_abnormal_middle_ear0.92634965
101MP0004811_abnormal_neuron_physiology0.91947048
102MP0005389_reproductive_system_phenotype0.91630725
103MP0001299_abnormal_eye_distance/0.90765212
104MP0002928_abnormal_bile_duct0.89020159
105MP0003937_abnormal_limbs/digits/tail_de0.88859132
106MP0002160_abnormal_reproductive_system0.88475747
107MP0002876_abnormal_thyroid_physiology0.84955387
108MP0003385_abnormal_body_wall0.84369716
109MP0000003_abnormal_adipose_tissue0.83652720
110MP0003938_abnormal_ear_development0.83581631
111MP0003861_abnormal_nervous_system0.82103236
112MP0001664_abnormal_digestion0.81937011
113MP0008569_lethality_at_weaning0.81023251
114MP0002229_neurodegeneration0.80797766
115MP0008995_early_reproductive_senescence0.80729554
116MP0002822_catalepsy0.80467030
117MP0003755_abnormal_palate_morphology0.80150395
118MP0005220_abnormal_exocrine_pancreas0.79979522
119MP0005195_abnormal_posterior_eye0.79720127
120MP0005187_abnormal_penis_morphology0.77559740
121MP0005174_abnormal_tail_pigmentation0.76965268
122MP0005499_abnormal_olfactory_system0.76413776
123MP0005394_taste/olfaction_phenotype0.76413776
124MP0003942_abnormal_urinary_system0.74670932
125MP0004264_abnormal_extraembryonic_tissu0.74134276
126MP0002069_abnormal_eating/drinking_beha0.72835139

Predicted human phenotypes

RankGene SetZ-score
1Decreased circulating renin level (HP:0003351)3.96666855
2Pancreatic fibrosis (HP:0100732)3.78344474
3Focal motor seizures (HP:0011153)3.61775534
4Pancreatic cysts (HP:0001737)3.59889940
5Atonic seizures (HP:0010819)3.53879401
6Nephronophthisis (HP:0000090)3.53798053
7Dynein arm defect of respiratory motile cilia (HP:0012255)3.47632781
8Absent/shortened dynein arms (HP:0200106)3.47632781
9Hypothermia (HP:0002045)3.46218430
10Chronic hepatic failure (HP:0100626)3.44550085
11Febrile seizures (HP:0002373)3.29486381
12Hypoplastic ischia (HP:0003175)3.16189217
13Progressive cerebellar ataxia (HP:0002073)3.12103088
14Limb dystonia (HP:0002451)3.10796990
15Abnormality of the renal medulla (HP:0100957)2.98772073
16Epileptic encephalopathy (HP:0200134)2.90277960
17Aplasia cutis congenita (HP:0001057)2.89365133
18Hyperkalemia (HP:0002153)2.89364808
19Abnormality of the ischium (HP:0003174)2.82970931
20Abnormal ciliary motility (HP:0012262)2.81857747
21Volvulus (HP:0002580)2.79150276
22Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.70726178
23Abnormality of calcium-phosphate metabolism (HP:0100530)2.69403388
24Septo-optic dysplasia (HP:0100842)2.64039577
25Type II lissencephaly (HP:0007260)2.62476702
26Myokymia (HP:0002411)2.60137870
27Epileptiform EEG discharges (HP:0011182)2.59078507
28EEG with generalized epileptiform discharges (HP:0011198)2.56725037
29Gait imbalance (HP:0002141)2.55437387
30Focal seizures (HP:0007359)2.53779141
31Agitation (HP:0000713)2.51787587
32Hyperinsulinemic hypoglycemia (HP:0000825)2.51564961
33Anteriorly placed anus (HP:0001545)2.45742200
34Aplasia/Hypoplasia of the spleen (HP:0010451)2.45209433
35Pheochromocytoma (HP:0002666)2.42057462
36Hypsarrhythmia (HP:0002521)2.40796612
37Chronic bronchitis (HP:0004469)2.39073057
38Abnormality of the renal cortex (HP:0011035)2.35427399
39Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.34768661
40Absence seizures (HP:0002121)2.33725843
41Hyperventilation (HP:0002883)2.33658755
42Lissencephaly (HP:0001339)2.32206838
43Medial flaring of the eyebrow (HP:0010747)2.31841552
44Increased hepatocellular lipid droplets (HP:0006565)2.31117603
45Congenital primary aphakia (HP:0007707)2.30414324
46Asplenia (HP:0001746)2.27477155
47Abnormal respiratory motile cilium physiology (HP:0012261)2.26848087
48Visual hallucinations (HP:0002367)2.24931181
49Absent rod-and cone-mediated responses on ERG (HP:0007688)2.24579918
50Colon cancer (HP:0003003)2.21902131
51Cystic liver disease (HP:0006706)2.21496035
52Abnormal respiratory epithelium morphology (HP:0012253)2.19253595
53Abnormal respiratory motile cilium morphology (HP:0005938)2.19253595
54Lipid accumulation in hepatocytes (HP:0006561)2.19001543
55Genetic anticipation (HP:0003743)2.18867046
56Acute necrotizing encephalopathy (HP:0006965)2.18769477
57Generalized tonic-clonic seizures (HP:0002069)2.17981795
58Aplasia/Hypoplasia of the lens (HP:0008063)2.17008487
59Hemiparesis (HP:0001269)2.16593431
60Genital tract atresia (HP:0001827)2.13719679
61Abnormality of renin-angiotensin system (HP:0000847)2.12752717
62Anencephaly (HP:0002323)2.12308453
63Cerebellar dysplasia (HP:0007033)2.12276495
64Bilateral microphthalmos (HP:0007633)2.12119511
65Protruding tongue (HP:0010808)2.12086419
66Poor coordination (HP:0002370)2.11380583
67Sclerocornea (HP:0000647)2.10503025
68Gaze-evoked nystagmus (HP:0000640)2.08909103
69Anophthalmia (HP:0000528)2.08585882
70Abnormality of the nasolacrimal system (HP:0000614)2.08570772
71Mitochondrial inheritance (HP:0001427)2.07691189
72Hyperactive renin-angiotensin system (HP:0000841)2.07382240
73Absent eyebrow (HP:0002223)2.06662409
74Vaginal atresia (HP:0000148)2.04989187
75Nasolacrimal duct obstruction (HP:0000579)2.04717014
76Hypoglycemic seizures (HP:0002173)2.03770488
77Abnormal rod and cone electroretinograms (HP:0008323)2.03392383
78Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.03262639
79Decreased lacrimation (HP:0000633)2.03211684
80Abnormality of potassium homeostasis (HP:0011042)2.02995021
81Abnormality of the nasal septum (HP:0000419)2.01983670
82Postaxial foot polydactyly (HP:0001830)2.01586962
83Neuroendocrine neoplasm (HP:0100634)1.99794151
84Pachygyria (HP:0001302)1.98664077
85Aplasia/Hypoplasia of the tongue (HP:0010295)1.97467299
86Dialeptic seizures (HP:0011146)1.97335476
87Postaxial hand polydactyly (HP:0001162)1.95602892
88Optic nerve hypoplasia (HP:0000609)1.95301555
89Nephrogenic diabetes insipidus (HP:0009806)1.94412244
90Drooling (HP:0002307)1.92128818
91Excessive salivation (HP:0003781)1.92128818
92Hypokalemia (HP:0002900)1.91986445
93Congenital hepatic fibrosis (HP:0002612)1.91926396
94Osteomalacia (HP:0002749)1.91670660
95Abnormality of the lacrimal duct (HP:0011481)1.91292458
96Blue irides (HP:0000635)1.90155208
97Abnormality of midbrain morphology (HP:0002418)1.89736345
98Molar tooth sign on MRI (HP:0002419)1.89736345
99Renal cortical cysts (HP:0000803)1.88982357
100Exotropia (HP:0000577)1.88226937
101Acute encephalopathy (HP:0006846)1.87264614
102Tubulointerstitial nephritis (HP:0001970)1.87150465
103Oligodactyly (hands) (HP:0001180)1.86509888
104Anomalous pulmonary venous return (HP:0010772)1.86022297
105Dysdiadochokinesis (HP:0002075)1.84731591
106Intestinal atresia (HP:0011100)1.84102931
107Amblyopia (HP:0000646)1.83983826
108Small hand (HP:0200055)1.83981941
109Occipital encephalocele (HP:0002085)1.83900806
110Aplasia/Hypoplasia of the uvula (HP:0010293)1.83297187
111True hermaphroditism (HP:0010459)1.82799132
112Progressive macrocephaly (HP:0004481)1.82767866
113Broad-based gait (HP:0002136)1.82668171
114Dandy-Walker malformation (HP:0001305)1.82442726
115Alacrima (HP:0000522)1.81794642
116Abnormality of the labia minora (HP:0012880)1.79677385
117Preaxial hand polydactyly (HP:0001177)1.79632009
118Bile duct proliferation (HP:0001408)1.79415374
119Abnormal biliary tract physiology (HP:0012439)1.79415374
120Increased CSF lactate (HP:0002490)1.78886848
121Abnormality of salivation (HP:0100755)1.78066956
122Polyphagia (HP:0002591)1.77932400
123Congenital stationary night blindness (HP:0007642)1.77816461
124Fibular hypoplasia (HP:0003038)1.76806192
125Renal hypoplasia (HP:0000089)1.76647483
126Attenuation of retinal blood vessels (HP:0007843)1.76429915
127Abnormal lung lobation (HP:0002101)1.76364264
128Inability to walk (HP:0002540)1.76075516
129Hepatocellular necrosis (HP:0001404)1.75419181
130Thyroid-stimulating hormone excess (HP:0002925)1.75275042
131Concave nail (HP:0001598)1.75202357
132White forelock (HP:0002211)1.74350056
133Morphological abnormality of the middle ear (HP:0008609)1.73452176
134Short 4th metacarpal (HP:0010044)1.72011441
135Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.72011441
136Abnormality of renal resorption (HP:0011038)1.71583804
137Microglossia (HP:0000171)1.70936987
138Narrow forehead (HP:0000341)1.70778175
139Male pseudohermaphroditism (HP:0000037)1.70502734
140Broad foot (HP:0001769)1.70066220
141Hyperaldosteronism (HP:0000859)1.69386549
142Aganglionic megacolon (HP:0002251)1.69285061
143Abnormal mitochondria in muscle tissue (HP:0008316)1.68800861
144Gastroesophageal reflux (HP:0002020)1.68750085
145Microvesicular hepatic steatosis (HP:0001414)1.68098033
146Symptomatic seizures (HP:0011145)1.67768934
147Fair hair (HP:0002286)1.67546668
148Abnormality of the ileum (HP:0001549)1.67002675
149Hyperglycemia (HP:0003074)1.66870693
150Multicystic kidney dysplasia (HP:0000003)1.66669776
151Gastrointestinal atresia (HP:0002589)1.66305414
152Hypoplasia of the fovea (HP:0007750)1.65987668
153Aplasia/Hypoplasia of the fovea (HP:0008060)1.65987668
154Specific learning disability (HP:0001328)1.65984840
155Ectopic kidney (HP:0000086)1.65975700
156Abolished electroretinogram (ERG) (HP:0000550)1.65036810
157Generalized hypopigmentation of hair (HP:0011358)1.64925529
158Supernumerary spleens (HP:0009799)1.64548846
159Tented upper lip vermilion (HP:0010804)1.64543478
160Optic disc pallor (HP:0000543)1.63778468
161Abnormality of the pulmonary veins (HP:0011718)1.63726128
162Thickened helices (HP:0000391)1.63389248
163Bell-shaped thorax (HP:0001591)1.63157218
164Absent septum pellucidum (HP:0001331)1.62972312
165Congenital sensorineural hearing impairment (HP:0008527)1.62358006

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.97383494
2INSRR3.55249969
3CASK3.46749097
4AKT33.45589241
5TNIK3.42342851
6MAP4K22.76475157
7MKNK22.60277875
8MARK12.44368465
9WNK32.12638196
10PRKD31.94223524
11MAPK131.86733385
12PNCK1.76228351
13DYRK31.70987777
14MAP3K61.69902375
15MAP2K71.68695717
16CDK191.62836158
17WNK41.62347679
18NTRK21.59515743
19UHMK11.58757628
20PINK11.56694778
21ZAK1.55442081
22MAP3K41.54651106
23ADRBK21.50717917
24TLK11.49621979
25PRPF4B1.46735274
26MKNK11.42952523
27ACVR1B1.41517109
28PASK1.39682746
29BLK1.32004894
30MAP2K41.29675650
31GRK71.28170714
32MAPK151.23604448
33HIPK21.22463670
34EPHB21.21607786
35TRIM281.18586268
36BRD41.15865962
37WNK11.15523922
38ADRBK11.14124682
39CDC42BPA1.13207937
40BMPR1B1.10738342
41NUAK11.10581440
42SGK2231.10275682
43SGK4941.10275682
44SRPK11.09555250
45SGK21.09413706
46EPHA21.09313317
47CDK121.08887230
48GRK51.08178997
49CSNK1G21.04162961
50GRK11.03551805
51PLK41.02993753
52MINK11.02657444
53DYRK1A1.02096795
54MARK30.99832700
55PKN10.99597685
56ERBB30.98897452
57STK160.96313553
58IRAK10.96174107
59TAF10.96087914
60TAOK30.93817293
61DYRK20.92140807
62SIK20.90809973
63PRKCE0.89396812
64EPHA40.89285482
65STK390.88573722
66CAMK1G0.86272655
67CDC70.85084664
68BCR0.85049872
69NEK60.84331846
70VRK10.83869972
71CDK80.82927704
72DAPK20.80980863
73CAMK2B0.80733951
74CAMK2A0.80660166
75BRAF0.80282847
76YES10.78620270
77CSNK1A1L0.74439780
78STK110.73943669
79FGFR20.73197135
80PRKD20.73152132
81DYRK1B0.70682952
82SGK10.68882705
83CCNB10.68872975
84SIK30.67105409
85ERBB40.66315149
86OXSR10.66265784
87PLK20.66164172
88BCKDK0.65361045
89TGFBR10.64710044
90PAK30.64076361
91CDK50.64031001
92MAP3K20.63999319
93MAP3K120.62924868
94FGR0.62054325
95BRSK20.61577782
96CAMKK20.61146009
97PRKG10.60379078
98CSNK1G30.60310165
99LATS10.59785404
100PLK10.59762722
101PRKCH0.59557217
102CAMK40.59457882
103CSNK1E0.59055135
104CAMK2D0.58334469
105PLK30.58013507
106NTRK10.55945472
107PRKCG0.55838538
108RPS6KA40.55586234
109IRAK30.55135014
110RPS6KA30.53310398
111TYRO30.53139262
112MAP3K70.51941606
113CDK30.51908372
114PRKACA0.50446621
115CSNK1G10.48961144
116MAP3K90.48195351
117PRKCZ0.47876068
118PAK60.47803671
119GSK3B0.47207663
120RPS6KB10.47112317
121MAP2K60.46379912
122FRK0.45128266
123EPHA30.44391342
124NME10.44331888
125PRKCB0.44301318
126MAP3K110.43784791
127MARK20.42509998
128FER0.41636222
129PHKG20.41553999
130PHKG10.41553999
131IRAK20.41196019
132RPS6KA20.41029948
133PRKDC0.40484846
134CAMK10.39985921
135SGK30.38580569
136LIMK10.38311932
137ATR0.35767459
138NEK20.34972409
139STK38L0.34624743
140RPS6KA50.33264471
141ATM0.33155592
142CHEK20.32204488
143PRKCQ0.31353362

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.80033294
2Nicotine addiction_Homo sapiens_hsa050333.68505752
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.92297713
4Insulin secretion_Homo sapiens_hsa049112.79555436
5Taste transduction_Homo sapiens_hsa047422.65248917
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.61743566
7GABAergic synapse_Homo sapiens_hsa047272.54378120
8Circadian entrainment_Homo sapiens_hsa047132.29572437
9Morphine addiction_Homo sapiens_hsa050322.27894649
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.24601910
11Serotonergic synapse_Homo sapiens_hsa047262.21389056
12Glutamatergic synapse_Homo sapiens_hsa047242.11562782
13RNA polymerase_Homo sapiens_hsa030202.02992908
14Amphetamine addiction_Homo sapiens_hsa050311.98753726
15Cocaine addiction_Homo sapiens_hsa050301.95704235
16Synaptic vesicle cycle_Homo sapiens_hsa047211.90700202
17Dopaminergic synapse_Homo sapiens_hsa047281.90318116
18Phototransduction_Homo sapiens_hsa047441.88508266
19Long-term potentiation_Homo sapiens_hsa047201.85643005
20Fanconi anemia pathway_Homo sapiens_hsa034601.81867039
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.76595864
22Protein export_Homo sapiens_hsa030601.73239805
23Type II diabetes mellitus_Homo sapiens_hsa049301.61011159
24Basal transcription factors_Homo sapiens_hsa030221.60693777
25Long-term depression_Homo sapiens_hsa047301.55761475
26Cholinergic synapse_Homo sapiens_hsa047251.53151197
27Salivary secretion_Homo sapiens_hsa049701.50203604
28Olfactory transduction_Homo sapiens_hsa047401.50101986
29Homologous recombination_Homo sapiens_hsa034401.48048739
30Renin secretion_Homo sapiens_hsa049241.45993741
31Butanoate metabolism_Homo sapiens_hsa006501.38209418
32Circadian rhythm_Homo sapiens_hsa047101.37440621
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35778301
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29428563
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29156902
36Collecting duct acid secretion_Homo sapiens_hsa049661.28474424
37RNA degradation_Homo sapiens_hsa030181.27951893
38Linoleic acid metabolism_Homo sapiens_hsa005911.26804190
39Oxidative phosphorylation_Homo sapiens_hsa001901.26136230
40Vibrio cholerae infection_Homo sapiens_hsa051101.22963019
41Calcium signaling pathway_Homo sapiens_hsa040201.22604978
42Ribosome_Homo sapiens_hsa030101.18804452
43Selenocompound metabolism_Homo sapiens_hsa004501.12164037
44Dorso-ventral axis formation_Homo sapiens_hsa043201.10391432
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10258304
46Axon guidance_Homo sapiens_hsa043601.10165128
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08974981
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08718038
49Alzheimers disease_Homo sapiens_hsa050101.04182083
50Tryptophan metabolism_Homo sapiens_hsa003801.02593023
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00740732
52Oxytocin signaling pathway_Homo sapiens_hsa049210.99083357
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98442866
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.94858879
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94241477
56Propanoate metabolism_Homo sapiens_hsa006400.93694071
57Cardiac muscle contraction_Homo sapiens_hsa042600.91490898
58Gastric acid secretion_Homo sapiens_hsa049710.90901684
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89469513
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88945651
61Pancreatic secretion_Homo sapiens_hsa049720.87783249
62cAMP signaling pathway_Homo sapiens_hsa040240.85969619
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85117355
64Type I diabetes mellitus_Homo sapiens_hsa049400.84218215
65Hippo signaling pathway_Homo sapiens_hsa043900.83334217
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82972105
67Parkinsons disease_Homo sapiens_hsa050120.81665140
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81031555
69Melanogenesis_Homo sapiens_hsa049160.80158461
70Sulfur metabolism_Homo sapiens_hsa009200.80055401
71Gap junction_Homo sapiens_hsa045400.78662904
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77515126
73Wnt signaling pathway_Homo sapiens_hsa043100.75938599
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74213101
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73250051
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72681773
77Purine metabolism_Homo sapiens_hsa002300.72447133
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72315644
79Caffeine metabolism_Homo sapiens_hsa002320.72175995
80Thyroid hormone synthesis_Homo sapiens_hsa049180.70693191
81Steroid biosynthesis_Homo sapiens_hsa001000.70218398
82Estrogen signaling pathway_Homo sapiens_hsa049150.68914684
83Melanoma_Homo sapiens_hsa052180.68460653
84Alcoholism_Homo sapiens_hsa050340.66299913
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66128781
86MAPK signaling pathway_Homo sapiens_hsa040100.66063791
87Hedgehog signaling pathway_Homo sapiens_hsa043400.65992898
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64804811
89Glucagon signaling pathway_Homo sapiens_hsa049220.64200882
90Sphingolipid metabolism_Homo sapiens_hsa006000.64154167
91Mismatch repair_Homo sapiens_hsa034300.63644830
92Ras signaling pathway_Homo sapiens_hsa040140.62849026
93Prion diseases_Homo sapiens_hsa050200.61951694
94Ether lipid metabolism_Homo sapiens_hsa005650.60164181
95Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.59896858
96Huntingtons disease_Homo sapiens_hsa050160.58977943
97GnRH signaling pathway_Homo sapiens_hsa049120.58903158
98Peroxisome_Homo sapiens_hsa041460.57743034
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.56884857
100Dilated cardiomyopathy_Homo sapiens_hsa054140.55353149
101Ovarian steroidogenesis_Homo sapiens_hsa049130.54037656
102Metabolic pathways_Homo sapiens_hsa011000.51202284
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51095629
104TGF-beta signaling pathway_Homo sapiens_hsa043500.50835298
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50710763
106ErbB signaling pathway_Homo sapiens_hsa040120.48472175
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48089652
108Retinol metabolism_Homo sapiens_hsa008300.47930911
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47282602
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47021340
111Rap1 signaling pathway_Homo sapiens_hsa040150.45533368
112Chemical carcinogenesis_Homo sapiens_hsa052040.45103813
113Glycerolipid metabolism_Homo sapiens_hsa005610.43818232
114Cysteine and methionine metabolism_Homo sapiens_hsa002700.42842220
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42553499
116Basal cell carcinoma_Homo sapiens_hsa052170.42513896
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40330933
118Regulation of autophagy_Homo sapiens_hsa041400.40210765
119Base excision repair_Homo sapiens_hsa034100.40209810
120Pyrimidine metabolism_Homo sapiens_hsa002400.38044919
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36823352
122RNA transport_Homo sapiens_hsa030130.35970266
123Non-homologous end-joining_Homo sapiens_hsa034500.35586277
124One carbon pool by folate_Homo sapiens_hsa006700.34843388
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34590336
126Nitrogen metabolism_Homo sapiens_hsa009100.34497802
127Fatty acid elongation_Homo sapiens_hsa000620.34044349
128mRNA surveillance pathway_Homo sapiens_hsa030150.33491574
129Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32910846
130Oocyte meiosis_Homo sapiens_hsa041140.31032930
131Rheumatoid arthritis_Homo sapiens_hsa053230.30748604
132Lysine degradation_Homo sapiens_hsa003100.25365372
133Insulin signaling pathway_Homo sapiens_hsa049100.22922935
134Inositol phosphate metabolism_Homo sapiens_hsa005620.22857029
135Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22740663
136Prolactin signaling pathway_Homo sapiens_hsa049170.22568802
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22285352
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21948769
139Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21681245
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19867359

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