XKR7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1layer formation in cerebral cortex (GO:0021819)5.61987989
2response to pheromone (GO:0019236)5.39082980
3pyrimidine nucleobase catabolic process (GO:0006208)5.26370023
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.19830106
5positive regulation of synapse maturation (GO:0090129)5.17189159
6positive regulation of synaptic transmission, dopaminergic (GO:0032226)5.09272787
7regulation of short-term neuronal synaptic plasticity (GO:0048172)5.03147727
8synaptic vesicle maturation (GO:0016188)4.85156477
9cell migration in hindbrain (GO:0021535)4.73983540
10locomotory exploration behavior (GO:0035641)4.71437919
11cerebellar granule cell differentiation (GO:0021707)4.49604028
12behavioral response to nicotine (GO:0035095)4.41396821
13neuron cell-cell adhesion (GO:0007158)4.39028644
14presynaptic membrane assembly (GO:0097105)4.38543037
15cerebellar Purkinje cell layer development (GO:0021680)4.37888126
16dendrite morphogenesis (GO:0048813)4.32021550
17central nervous system projection neuron axonogenesis (GO:0021952)4.28815313
18neuromuscular synaptic transmission (GO:0007274)4.28412339
19axonal fasciculation (GO:0007413)4.24515495
20regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.12819268
21positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.01020998
22dendritic spine morphogenesis (GO:0060997)3.97827127
23nucleobase catabolic process (GO:0046113)3.97729225
24vocalization behavior (GO:0071625)3.90607157
25regulation of synaptic vesicle exocytosis (GO:2000300)3.88735310
26neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.85010115
27cerebellum development (GO:0021549)3.84292593
28response to auditory stimulus (GO:0010996)3.84148751
29cerebellar Purkinje cell differentiation (GO:0021702)3.81789272
30regulation of synapse maturation (GO:0090128)3.79583391
31protein localization to synapse (GO:0035418)3.78670888
32neuron recognition (GO:0008038)3.78002213
33mechanosensory behavior (GO:0007638)3.75471750
34regulation of respiratory system process (GO:0044065)3.75142528
35establishment of nucleus localization (GO:0040023)3.71723128
36negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.69258199
37cell differentiation in hindbrain (GO:0021533)3.59323165
38positive regulation of dendritic spine morphogenesis (GO:0061003)3.56991456
39regulation of glutamate receptor signaling pathway (GO:1900449)3.56056150
40positive regulation of neurotransmitter transport (GO:0051590)3.54788789
41synaptic vesicle docking involved in exocytosis (GO:0016081)3.50582961
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.47818035
43ganglion development (GO:0061548)3.46042042
44neurotransmitter transport (GO:0006836)3.45371014
45negative regulation of cytosolic calcium ion concentration (GO:0051481)3.44974697
46synaptic vesicle exocytosis (GO:0016079)3.41051018
47exploration behavior (GO:0035640)3.35396419
48negative regulation of microtubule polymerization (GO:0031115)3.33530202
49mating behavior (GO:0007617)3.32778678
50central nervous system neuron axonogenesis (GO:0021955)3.32629524
51proline transport (GO:0015824)3.30468819
52detection of temperature stimulus (GO:0016048)3.30356282
53neurotransmitter secretion (GO:0007269)3.28561726
54regulation of respiratory gaseous exchange (GO:0043576)3.27607123
55glutamate secretion (GO:0014047)3.26466839
56regulation of synaptic transmission, glutamatergic (GO:0051966)3.26340555
57regulation of neurotransmitter secretion (GO:0046928)3.25319992
58regulation of neuron migration (GO:2001222)3.24141582
59regulation of vesicle fusion (GO:0031338)3.22850000
60gamma-aminobutyric acid transport (GO:0015812)3.19435861
61innervation (GO:0060384)3.17678570
62regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.16937552
63regulation of neurotransmitter levels (GO:0001505)3.14519061
64enteric nervous system development (GO:0048484)3.14198950
65activation of protein kinase A activity (GO:0034199)3.13012845
66regulation of synaptic vesicle transport (GO:1902803)3.12279951
67mitochondrion transport along microtubule (GO:0047497)3.11021622
68establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.11021622
69detection of temperature stimulus involved in sensory perception (GO:0050961)3.10154465
70detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.10154465
71neuronal ion channel clustering (GO:0045161)3.09558027
72neuromuscular process controlling balance (GO:0050885)3.09479901
73ionotropic glutamate receptor signaling pathway (GO:0035235)3.09105429
74regulation of long-term neuronal synaptic plasticity (GO:0048169)3.08475836
75neurotransmitter-gated ion channel clustering (GO:0072578)3.08109947
76regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.06453528
77synaptic transmission, glutamatergic (GO:0035249)3.03343805
78regulation of postsynaptic membrane potential (GO:0060078)3.02187607
79sympathetic nervous system development (GO:0048485)3.01326516
80regulation of neurotransmitter transport (GO:0051588)3.01256868
81suckling behavior (GO:0001967)2.96003218
82paraxial mesoderm development (GO:0048339)2.94315707
83glutamate receptor signaling pathway (GO:0007215)2.93486676
84regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.92472515
85establishment of mitochondrion localization (GO:0051654)2.92195454
86positive regulation of synapse assembly (GO:0051965)2.92024504
87synaptic transmission, cholinergic (GO:0007271)2.91841355
88organelle transport along microtubule (GO:0072384)2.91761086
89regulation of neuronal synaptic plasticity (GO:0048168)2.90499266
90spinal cord development (GO:0021510)2.90476011
91presynaptic membrane organization (GO:0097090)2.89650855
92cell communication by electrical coupling (GO:0010644)2.89226432
93dendritic spine organization (GO:0097061)2.89211642
94negative regulation of dendrite morphogenesis (GO:0050774)2.88878452
95postsynaptic membrane organization (GO:0001941)2.88424383
96synaptic vesicle endocytosis (GO:0048488)2.87952952
97adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.87142236
98dopamine receptor signaling pathway (GO:0007212)2.86895816
99positive regulation of neurotransmitter secretion (GO:0001956)2.86892652
100regulation of synapse structural plasticity (GO:0051823)2.86320826
101regulation of axon extension (GO:0030516)2.84962055
102neuron migration (GO:0001764)2.84508505
103regulation of calcium ion-dependent exocytosis (GO:0017158)2.84379204
104negative regulation of catenin import into nucleus (GO:0035414)2.84123094
105transmission of nerve impulse (GO:0019226)2.83816163
106cellular potassium ion homeostasis (GO:0030007)2.82248900
107axon cargo transport (GO:0008088)2.80575217
108adult walking behavior (GO:0007628)2.77105733
109G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.76427005
110regulation of NFAT protein import into nucleus (GO:0051532)2.75603229
111chemosensory behavior (GO:0007635)2.74309733
112nerve growth factor signaling pathway (GO:0038180)2.72479121
113regulation of dendritic spine morphogenesis (GO:0061001)2.72302645
114synapse assembly (GO:0007416)2.72182599
115membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.71807100
116positive regulation of dendritic spine development (GO:0060999)2.71495677
117auditory behavior (GO:0031223)2.69720153
118neuron-neuron synaptic transmission (GO:0007270)2.67774008
119axon extension (GO:0048675)2.67126380
120sodium ion export (GO:0071436)2.66938771
121long-term memory (GO:0007616)2.66827744
122hippocampus development (GO:0021766)2.66496628
123positive regulation of axon extension (GO:0045773)2.66311300
124neuron projection morphogenesis (GO:0048812)2.65543202
125negative regulation of axon extension (GO:0030517)2.63594101
126positive regulation of dendrite morphogenesis (GO:0050775)2.63162651
127cytoskeletal anchoring at plasma membrane (GO:0007016)2.63043145
128neuronal action potential propagation (GO:0019227)2.61699120
129positive regulation of membrane potential (GO:0045838)2.61688022
130synapse organization (GO:0050808)2.61138230
131cerebral cortex radially oriented cell migration (GO:0021799)2.61058907
132regulation of excitatory postsynaptic membrane potential (GO:0060079)2.60643279
133regulation of extent of cell growth (GO:0061387)2.60168770
134membrane depolarization during action potential (GO:0086010)2.59625010
135regulation of ARF protein signal transduction (GO:0032012)2.59001424
136regulation of axonogenesis (GO:0050770)2.58602065

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.34982042
2* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.09479574
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.82925315
4* REST_21632747_ChIP-Seq_MESCs_Mouse2.82458921
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.62092440
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.58496862
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.58496862
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.56057495
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.52174314
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.49385220
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.49138168
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.48295169
13EZH2_27294783_Chip-Seq_ESCs_Mouse2.42234819
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38092490
15* DROSHA_22980978_ChIP-Seq_HELA_Human2.38006520
16RNF2_27304074_Chip-Seq_ESCs_Mouse2.34884590
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.26798535
18* REST_18959480_ChIP-ChIP_MESCs_Mouse2.26334422
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.25424176
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.24664681
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.19640999
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.18641484
23MTF2_20144788_ChIP-Seq_MESCs_Mouse2.16141298
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.13941223
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13315413
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.07052281
27GBX2_23144817_ChIP-Seq_PC3_Human2.06067500
28ERG_21242973_ChIP-ChIP_JURKAT_Human2.06008233
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05262233
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.98481350
31KDM2B_26808549_Chip-Seq_K562_Human1.97208565
32* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.92790673
33TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.83104243
34RING1B_27294783_Chip-Seq_NPCs_Mouse1.79067576
35* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.69862160
36RING1B_27294783_Chip-Seq_ESCs_Mouse1.69568479
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.67514304
38ZFP281_27345836_Chip-Seq_ESCs_Mouse1.66762615
39EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.59978804
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.57993571
41ZNF274_21170338_ChIP-Seq_K562_Hela1.57696438
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.56833057
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54531354
44* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.50121856
45DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.42479352
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42391741
47SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.42257101
48* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.38641067
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37744062
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35594165
51SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.35156507
52AR_19668381_ChIP-Seq_PC3_Human1.30312391
53RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.29721422
54KDM2B_26808549_Chip-Seq_DND41_Human1.27494321
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26568649
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24911084
57DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22627461
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22606928
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.22236193
60KDM2B_26808549_Chip-Seq_JURKAT_Human1.21995838
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21603023
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21266318
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.17216436
64TP53_20018659_ChIP-ChIP_R1E_Mouse1.16539884
65YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16367628
66GATA1_26923725_Chip-Seq_HPCs_Mouse1.16027018
67ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13795081
68NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13284861
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12450324
70IGF1R_20145208_ChIP-Seq_DFB_Human1.11802162
71* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09164473
72SMAD3_21741376_ChIP-Seq_ESCs_Human1.09104916
73ZNF263_19887448_ChIP-Seq_K562_Human1.09026984
74RNF2_27304074_Chip-Seq_NSC_Mouse1.07419291
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04867910
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04867910
77HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.04365476
78CTCF_27219007_Chip-Seq_Bcells_Human1.03920461
79CREB1_26743006_Chip-Seq_LNCaP_Human1.01851838
80ISL1_27105846_Chip-Seq_CPCs_Mouse1.01755747
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01010518
82* TET1_21490601_ChIP-Seq_MESCs_Mouse0.99767385
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99236454
84FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.98945405
85STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98428599
86ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97035144
87LXR_22292898_ChIP-Seq_THP-1_Human0.97021678
88SMAD4_21741376_ChIP-Seq_HESCs_Human0.96571332
89STAT3_23295773_ChIP-Seq_U87_Human0.96246174
90RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95914428
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93965835
92SMAD4_21799915_ChIP-Seq_A2780_Human0.93792156
93AR_21572438_ChIP-Seq_LNCaP_Human0.93403423
94KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91802735
95CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91189944
96CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90569490
97CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89676873
98P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89298206
99* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88729996
100ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88500700
101NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87212242
102P53_22127205_ChIP-Seq_FIBROBLAST_Human0.85885163
103AHR_22903824_ChIP-Seq_MCF-7_Human0.84993336
104ARNT_22903824_ChIP-Seq_MCF-7_Human0.84165363
105NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.83949636
106OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83713280
107POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83694151
108DPY_21335234_ChIP-Seq_ESCs_Mouse0.83541760
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83137734
110* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82929313
111ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.82196750
112SMAD3_21741376_ChIP-Seq_EPCs_Human0.81632497
113POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.81530942
114BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.81145921
115CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.81084145
116TAF15_26573619_Chip-Seq_HEK293_Human0.77412881
117LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77350980
118SOX3_22085726_ChIP-Seq_NPCs_Mouse0.74594870
119* STAT3_18555785_ChIP-Seq_MESCs_Mouse0.74477211
120WDR5_24793694_ChIP-Seq_LNCAP_Human0.73703992
121MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.71547571
122POU5F1_16518401_ChIP-PET_MESCs_Mouse0.71517223
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71161440

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy5.71691012
2MP0004859_abnormal_synaptic_plasticity4.32406958
3MP0005423_abnormal_somatic_nervous3.36205851
4MP0004270_analgesia3.33894986
5MP0003635_abnormal_synaptic_transmissio3.03514832
6MP0009780_abnormal_chondrocyte_physiolo2.94317234
7MP0000778_abnormal_nervous_system2.88594359
8MP0002734_abnormal_mechanical_nocicepti2.56537994
9MP0002184_abnormal_innervation2.48821385
10MP0005187_abnormal_penis_morphology2.42688815
11MP0002063_abnormal_learning/memory/cond2.40006993
12MP0004858_abnormal_nervous_system2.39334291
13MP0009046_muscle_twitch2.31003975
14MP0002909_abnormal_adrenal_gland2.29224527
15MP0002653_abnormal_ependyma_morphology2.12902137
16MP0006072_abnormal_retinal_apoptosis2.10838030
17MP0000955_abnormal_spinal_cord2.07444972
18MP0003283_abnormal_digestive_organ2.05196291
19MP0001188_hyperpigmentation2.04430279
20MP0009745_abnormal_behavioral_response2.00675462
21MP0003880_abnormal_central_pattern1.99602764
22MP0002733_abnormal_thermal_nociception1.96734279
23MP0001968_abnormal_touch/_nociception1.95784711
24MP0002064_seizures1.93257925
25MP0004811_abnormal_neuron_physiology1.91305653
26MP0004885_abnormal_endolymph1.89993389
27MP0002572_abnormal_emotion/affect_behav1.89956331
28MP0003787_abnormal_imprinting1.88636644
29MP0002067_abnormal_sensory_capabilities1.83918580
30MP0002735_abnormal_chemical_nociception1.81586993
31MP0001486_abnormal_startle_reflex1.79616032
32MP0001529_abnormal_vocalization1.78520091
33MP0000569_abnormal_digit_pigmentation1.76377869
34MP0005409_darkened_coat_color1.76276423
35MP0001440_abnormal_grooming_behavior1.73866753
36MP0008569_lethality_at_weaning1.72708919
37MP0008961_abnormal_basal_metabolism1.71130965
38MP0002557_abnormal_social/conspecific_i1.68742039
39MP0002272_abnormal_nervous_system1.67756868
40MP0002882_abnormal_neuron_morphology1.61937241
41MP0001970_abnormal_pain_threshold1.60825733
42MP0006276_abnormal_autonomic_nervous1.53671657
43MP0002152_abnormal_brain_morphology1.52769954
44MP0000537_abnormal_urethra_morphology1.52423190
45MP0000631_abnormal_neuroendocrine_gland1.51864814
46MP0001299_abnormal_eye_distance/1.46459843
47MP0006292_abnormal_olfactory_placode1.42950823
48MP0002736_abnormal_nociception_after1.42920005
49MP0005499_abnormal_olfactory_system1.41803428
50MP0005394_taste/olfaction_phenotype1.41803428
51MP0003861_abnormal_nervous_system1.38245940
52MP0001502_abnormal_circadian_rhythm1.37023905
53MP0003123_paternal_imprinting1.35681144
54MP0002234_abnormal_pharynx_morphology1.35257694
55MP0004145_abnormal_muscle_electrophysio1.33057438
56MP0005386_behavior/neurological_phenoty1.31486287
57MP0004924_abnormal_behavior1.31486287
58MP0003329_amyloid_beta_deposits1.31360399
59MP0010386_abnormal_urinary_bladder1.31250259
60MP0002066_abnormal_motor_capabilities/c1.31218290
61MP0005645_abnormal_hypothalamus_physiol1.31051610
62MP0008789_abnormal_olfactory_epithelium1.30495389
63MP0003119_abnormal_digestive_system1.20652159
64MP0002638_abnormal_pupillary_reflex1.19277551
65MP0004742_abnormal_vestibular_system1.17052196
66MP0002751_abnormal_autonomic_nervous1.16535267
67MP0005253_abnormal_eye_physiology1.14070707
68MP0003183_abnormal_peptide_metabolism1.11991234
69MP0003890_abnormal_embryonic-extraembry1.10669271
70MP0001348_abnormal_lacrimal_gland1.08795047
71MP0003172_abnormal_lysosome_physiology1.08144554
72MP0001905_abnormal_dopamine_level1.06410932
73MP0002752_abnormal_somatic_nervous1.05870700
74MP0001984_abnormal_olfaction1.05363364
75MP0005076_abnormal_cell_differentiation1.04456240
76MP0003634_abnormal_glial_cell1.01180995
77MP0005551_abnormal_eye_electrophysiolog1.00850155
78MP0003632_abnormal_nervous_system0.94797230
79MP0001944_abnormal_pancreas_morphology0.93887337
80MP0004142_abnormal_muscle_tone0.92649067
81MP0003879_abnormal_hair_cell0.92240257
82MP0002069_abnormal_eating/drinking_beha0.90784053
83MP0003122_maternal_imprinting0.89528051
84MP0003633_abnormal_nervous_system0.89364636
85MP0001501_abnormal_sleep_pattern0.88818049
86MP0002877_abnormal_melanocyte_morpholog0.88544321
87MP0002229_neurodegeneration0.88239165
88MP0004233_abnormal_muscle_weight0.85789250
89MP0008877_abnormal_DNA_methylation0.85553094
90MP0002163_abnormal_gland_morphology0.83625848
91MP0004043_abnormal_pH_regulation0.83182217
92MP0000678_abnormal_parathyroid_gland0.82941409
93MP0003631_nervous_system_phenotype0.82923479
94MP0000534_abnormal_ureter_morphology0.82723238
95MP0001943_abnormal_respiration0.82693278
96MP0000013_abnormal_adipose_tissue0.79709503
97MP0002081_perinatal_lethality0.79541084
98MP0005646_abnormal_pituitary_gland0.78384174
99MP0001177_atelectasis0.74980352
100MP0000462_abnormal_digestive_system0.74239296
101MP0003137_abnormal_impulse_conducting0.73963138
102MP0004133_heterotaxia0.73695709
103MP0010769_abnormal_survival0.72218109
104MP0002116_abnormal_craniofacial_bone0.71577989
105MP0010770_preweaning_lethality0.71291356
106MP0002082_postnatal_lethality0.71291356
107MP0004085_abnormal_heartbeat0.71160862
108MP0003121_genomic_imprinting0.70040056
109MP0001849_ear_inflammation0.69558607
110MP0000003_abnormal_adipose_tissue0.69516623
111MP0010768_mortality/aging0.69016639
112MP0005195_abnormal_posterior_eye0.68657418
113MP0009672_abnormal_birth_weight0.68632113
114MP0005377_hearing/vestibular/ear_phenot0.67556002
115MP0003878_abnormal_ear_physiology0.67556002
116MP0003948_abnormal_gas_homeostasis0.63231593
117MP0000538_abnormal_urinary_bladder0.63022510
118MP0002249_abnormal_larynx_morphology0.62546927
119MP0005257_abnormal_intraocular_pressure0.61343468
120MP0000566_synostosis0.60242047
121MP0003938_abnormal_ear_development0.59805598
122MP0003115_abnormal_respiratory_system0.59729007
123MP0001963_abnormal_hearing_physiology0.59057015

Predicted human phenotypes

RankGene SetZ-score
1Action tremor (HP:0002345)3.76607299
2Hyperacusis (HP:0010780)3.72518929
3Visual hallucinations (HP:0002367)3.72476218
4Insomnia (HP:0100785)3.51976499
5Elfin facies (HP:0004428)3.24612978
6Myokymia (HP:0002411)3.21863905
7Progressive cerebellar ataxia (HP:0002073)3.21142434
8Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.20918072
9Supranuclear gaze palsy (HP:0000605)3.18186041
10Agitation (HP:0000713)3.04332507
11Focal seizures (HP:0007359)3.00881076
12Overriding aorta (HP:0002623)2.98197077
13Epileptic encephalopathy (HP:0200134)2.95406335
14Torticollis (HP:0000473)2.92963114
15Abnormality of the corticospinal tract (HP:0002492)2.82429804
16Renovascular hypertension (HP:0100817)2.81256014
17Amyotrophic lateral sclerosis (HP:0007354)2.80782926
18Macroorchidism (HP:0000053)2.79013569
19EEG with generalized epileptiform discharges (HP:0011198)2.72718903
20Termporal pattern (HP:0011008)2.68392755
21Insidious onset (HP:0003587)2.68392755
22Hypsarrhythmia (HP:0002521)2.68313233
23Focal motor seizures (HP:0011153)2.62014985
24Epileptiform EEG discharges (HP:0011182)2.61537571
25Abnormality of the lower motor neuron (HP:0002366)2.56608289
26Impaired smooth pursuit (HP:0007772)2.55088618
27Vertebral arch anomaly (HP:0008438)2.53757176
28Genetic anticipation (HP:0003743)2.53707347
29Neoplasm of the heart (HP:0100544)2.53003451
30Renal duplication (HP:0000075)2.52014131
31Aqueductal stenosis (HP:0002410)2.51769178
32Polyphagia (HP:0002591)2.50556682
33Pheochromocytoma (HP:0002666)2.49327732
34Fetal akinesia sequence (HP:0001989)2.48926766
35Ankle clonus (HP:0011448)2.48808037
36Sleep apnea (HP:0010535)2.47541588
37Pointed chin (HP:0000307)2.40514779
38Truncal ataxia (HP:0002078)2.39128912
39Cortical dysplasia (HP:0002539)2.38492482
40Hemiparesis (HP:0001269)2.37273238
41Drooling (HP:0002307)2.31603369
42Excessive salivation (HP:0003781)2.31603369
43Depression (HP:0000716)2.31111460
44Papilledema (HP:0001085)2.30049206
45Poor eye contact (HP:0000817)2.28548874
46Obstructive sleep apnea (HP:0002870)2.28495440
47Abnormality of the aortic arch (HP:0012303)2.28359759
48Hyperventilation (HP:0002883)2.25931286
49Absence seizures (HP:0002121)2.24547445
50Broad-based gait (HP:0002136)2.22695797
51Megalencephaly (HP:0001355)2.22149601
52Abnormality of ocular smooth pursuit (HP:0000617)2.21345130
53Abnormal eating behavior (HP:0100738)2.20343763
54Volvulus (HP:0002580)2.20097727
55Hypercortisolism (HP:0001578)2.19896129
56Amblyopia (HP:0000646)2.18774014
57Atonic seizures (HP:0010819)2.17031415
58Bowel diverticulosis (HP:0005222)2.16663948
59Hepatoblastoma (HP:0002884)2.15623846
60Turricephaly (HP:0000262)2.13541450
61Morphological abnormality of the pyramidal tract (HP:0002062)2.13212548
62Cerebral inclusion bodies (HP:0100314)2.13162863
63Obsessive-compulsive behavior (HP:0000722)2.12872318
64Flat cornea (HP:0007720)2.12794998
65Abnormal social behavior (HP:0012433)2.11017403
66Impaired social interactions (HP:0000735)2.11017403
67Focal dystonia (HP:0004373)2.10727874
68Spastic gait (HP:0002064)2.10612031
69Abnormality of the parathyroid morphology (HP:0011766)2.10549371
70Intestinal atresia (HP:0011100)2.07897714
71Akinesia (HP:0002304)2.06764749
72Annular pancreas (HP:0001734)2.06248270
73Postural tremor (HP:0002174)2.05810200
74Increased nuchal translucency (HP:0010880)2.05483072
75Abnormality of calcium-phosphate metabolism (HP:0100530)2.05386692
76Abnormality of the diencephalon (HP:0010662)2.04944347
77Oligodactyly (hands) (HP:0001180)2.04765854
78Generalized hypotonia (HP:0001290)2.04274611
79Inappropriate behavior (HP:0000719)2.03230493
80Pachygyria (HP:0001302)2.02746051
81Sacral dimple (HP:0000960)2.02674254
82Craniofacial dystonia (HP:0012179)2.02091160
83Poor suck (HP:0002033)2.00877005
84Abnormality of the astrocytes (HP:0100707)2.00510572
85Astrocytoma (HP:0009592)2.00510572
86Open mouth (HP:0000194)1.99996138
87Hemiplegia (HP:0002301)1.99868846
88Impaired vibration sensation in the lower limbs (HP:0002166)1.99635199
89Stereotypic behavior (HP:0000733)1.96369026
90Aplasia/Hypoplasia of the brainstem (HP:0007362)1.96126112
91Hypoplasia of the brainstem (HP:0002365)1.96126112
92Dysdiadochokinesis (HP:0002075)1.96096145
93Apathy (HP:0000741)1.96010165
94Failure to thrive in infancy (HP:0001531)1.92755026
95Anomalous pulmonary venous return (HP:0010772)1.92748277
96Short 4th metacarpal (HP:0010044)1.91855152
97Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.91855152
98Shawl scrotum (HP:0000049)1.91656347
99Hypoventilation (HP:0002791)1.90967093
100Neuroendocrine neoplasm (HP:0100634)1.90053617
101Gaze-evoked nystagmus (HP:0000640)1.89813045
102Cutaneous finger syndactyly (HP:0010554)1.89222355
103Neurofibrillary tangles (HP:0002185)1.89016505
104Sporadic (HP:0003745)1.88687041
105Urinary bladder sphincter dysfunction (HP:0002839)1.87688296
106Abnormality of binocular vision (HP:0011514)1.87599447
107Diplopia (HP:0000651)1.87599447
108Mutism (HP:0002300)1.87380013
109Febrile seizures (HP:0002373)1.87214886
110Intention tremor (HP:0002080)1.86952046
111Enlarged penis (HP:0000040)1.85197875
112Germ cell neoplasia (HP:0100728)1.84499884
113Exotropia (HP:0000577)1.84160583
114Lower limb muscle weakness (HP:0007340)1.83823826
115Postural instability (HP:0002172)1.83745878
116Limb dystonia (HP:0002451)1.83707139
117Shallow orbits (HP:0000586)1.82552564
118Trigonocephaly (HP:0000243)1.82023038
119Spina bifida occulta (HP:0003298)1.81875904
120Abnormal hair whorl (HP:0010721)1.81450713
121Hypoplasia of the corpus callosum (HP:0002079)1.80984589
122Lissencephaly (HP:0001339)1.80448605
123Protruding tongue (HP:0010808)1.79854281
124Rib fusion (HP:0000902)1.78771730
125Papillary thyroid carcinoma (HP:0002895)1.78224624
126Dialeptic seizures (HP:0011146)1.78175203
127Generalized tonic-clonic seizures (HP:0002069)1.77416039
128Urinary urgency (HP:0000012)1.77358186
129Partial agenesis of the corpus callosum (HP:0001338)1.77071043
130Megalocornea (HP:0000485)1.76203304
131Abnormality of the intervertebral disk (HP:0005108)1.75188256
132Anxiety (HP:0000739)1.74806335
133Precocious puberty (HP:0000826)1.73662000
134Cutaneous syndactyly (HP:0012725)1.73425155
135Restlessness (HP:0000711)1.73367149
136Absent speech (HP:0001344)1.73219707
137Spastic tetraparesis (HP:0001285)1.70649651

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.49620970
2MAP3K93.25999897
3NTRK32.64671099
4NTRK22.40160751
5MAP3K42.22583976
6MINK12.15178700
7PAK62.01367706
8SIK21.95007329
9UHMK11.94750349
10CAMK1D1.90446797
11TYRO31.87238676
12CAMKK11.78780852
13ICK1.70417500
14TRIB31.67430457
15DYRK21.62681816
16EPHA41.61894369
17FGFR21.53802025
18PDGFRA1.53479271
19RIPK11.52124164
20KSR11.51667425
21ALK1.50139542
22MAPK131.48759401
23EPHB21.48409586
24DAPK21.46864449
25RET1.46081376
26NTRK11.43441493
27HIPK21.39153033
28ERBB31.30977626
29PRKD31.30833162
30TNIK1.19831607
31PHKG11.19582358
32PHKG21.19582358
33CDK51.18234064
34MAP3K21.18019997
35SCYL21.12777379
36BRD41.12448004
37MAP2K71.10715705
38STK111.10603626
39CDK191.09419823
40IRAK21.08198486
41EEF2K1.05325896
42CSNK1G21.04581521
43CAMKK21.03266169
44MARK21.01521699
45PTK20.96764273
46RPS6KA20.96064692
47TAOK10.95766769
48CDC42BPA0.95416636
49PNCK0.95104604
50DYRK1B0.90623035
51PTK60.90386597
52MAP3K100.89554703
53CDK150.86942951
54CAMK1G0.86902787
55PASK0.86460828
56CAMK10.86088114
57PRKCH0.85706413
58CDK120.85159460
59CDK180.84454056
60MATK0.80701359
61CSNK1A1L0.79834952
62KSR20.79370641
63PKN20.78254912
64CDK140.78074690
65PAK30.77111597
66CDK11A0.76444580
67LATS20.76394318
68INSRR0.75449619
69SIK10.74002785
70SGK2230.73021218
71SGK4940.73021218
72CSNK1G30.71667095
73WNK30.70302780
74LIMK10.69367660
75SGK10.68683950
76MAP2K40.68646434
77ERBB20.68332917
78PRKCG0.67285086
79DDR20.66396242
80PDGFRB0.66146743
81SGK30.63237178
82BCR0.60751462
83DYRK1A0.58112637
84PRKCZ0.56558208
85PKN10.56483918
86DAPK10.56355936
87MAPK90.56326777
88CAMK40.56295950
89CASK0.56284308
90NEK10.55887246
91MAP3K60.55756887
92PRKAA10.55744421
93FGFR10.54488667
94WNK10.53661442
95EPHA30.53241545
96CAMK2A0.50955170
97MTOR0.50466636
98CSNK1E0.50012317
99PINK10.49169901
100PRKCE0.47324063
101CAMK2B0.45680463
102PRKD20.44672147
103RPS6KA30.43865277
104MAPK100.43501620
105PRKDC0.42060781
106BRSK10.41795653
107GSK3B0.41559467
108MAP3K70.41224624
109ILK0.40967705
110SGK20.40949437
111MAPK80.40762391
112PRKCI0.40729778
113MAPK150.39941165
114CSNK1G10.39502805
115CSNK1D0.38546209
116PRPF4B0.36135255
117RPS6KB10.35508095
118TRIM280.32393314
119FYN0.32321779
120DAPK30.30989550
121DYRK30.29241338
122CSNK1A10.28275126

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.36302161
2Circadian entrainment_Homo sapiens_hsa047132.31208796
3Synaptic vesicle cycle_Homo sapiens_hsa047212.25626051
4Glutamatergic synapse_Homo sapiens_hsa047242.21387953
5GABAergic synapse_Homo sapiens_hsa047272.19459071
6Insulin secretion_Homo sapiens_hsa049112.14215648
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.14135209
8Type II diabetes mellitus_Homo sapiens_hsa049302.06150565
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.05268426
10Dopaminergic synapse_Homo sapiens_hsa047282.02717848
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.00717138
12Long-term potentiation_Homo sapiens_hsa047201.95261697
13Morphine addiction_Homo sapiens_hsa050321.92288160
14Cholinergic synapse_Homo sapiens_hsa047251.84303392
15Long-term depression_Homo sapiens_hsa047301.77495038
16Amphetamine addiction_Homo sapiens_hsa050311.72804011
17Axon guidance_Homo sapiens_hsa043601.68094757
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.63478043
19Estrogen signaling pathway_Homo sapiens_hsa049151.62261032
20Cocaine addiction_Homo sapiens_hsa050301.59664050
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.59224152
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.57341296
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55514723
24Taste transduction_Homo sapiens_hsa047421.54799648
25Gap junction_Homo sapiens_hsa045401.54305742
26Olfactory transduction_Homo sapiens_hsa047401.53217104
27Salivary secretion_Homo sapiens_hsa049701.51768072
28mTOR signaling pathway_Homo sapiens_hsa041501.41920692
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.36434949
30Gastric acid secretion_Homo sapiens_hsa049711.35863739
31Renin secretion_Homo sapiens_hsa049241.35282421
32Oxytocin signaling pathway_Homo sapiens_hsa049211.35126559
33Glioma_Homo sapiens_hsa052141.30984988
34Endometrial cancer_Homo sapiens_hsa052131.30942605
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28128684
36GnRH signaling pathway_Homo sapiens_hsa049121.27978479
37Serotonergic synapse_Homo sapiens_hsa047261.26751868
38ErbB signaling pathway_Homo sapiens_hsa040121.22786843
39Hedgehog signaling pathway_Homo sapiens_hsa043401.19801700
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.19488456
41Melanogenesis_Homo sapiens_hsa049161.15115266
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.15038581
43Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.14555082
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13371430
45Colorectal cancer_Homo sapiens_hsa052101.13002178
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.11153417
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05569382
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05204303
49cAMP signaling pathway_Homo sapiens_hsa040241.03707835
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03679174
51cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03433259
52Basal cell carcinoma_Homo sapiens_hsa052171.02273559
53Longevity regulating pathway - mammal_Homo sapiens_hsa042111.00491569
54Renal cell carcinoma_Homo sapiens_hsa052110.99604703
55Phototransduction_Homo sapiens_hsa047440.97810548
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97643301
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97614420
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94902712
59Non-small cell lung cancer_Homo sapiens_hsa052230.94504109
60Alcoholism_Homo sapiens_hsa050340.93589434
61Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93525566
62Thyroid hormone synthesis_Homo sapiens_hsa049180.92618143
63Oocyte meiosis_Homo sapiens_hsa041140.91156368
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.89818071
65VEGF signaling pathway_Homo sapiens_hsa043700.89162444
66Wnt signaling pathway_Homo sapiens_hsa043100.88621459
67Chronic myeloid leukemia_Homo sapiens_hsa052200.83942844
68Pancreatic secretion_Homo sapiens_hsa049720.82324843
69Hippo signaling pathway_Homo sapiens_hsa043900.79816976
70Calcium signaling pathway_Homo sapiens_hsa040200.79455697
71Prolactin signaling pathway_Homo sapiens_hsa049170.78161765
72Choline metabolism in cancer_Homo sapiens_hsa052310.77975135
73MAPK signaling pathway_Homo sapiens_hsa040100.77217462
74Cardiac muscle contraction_Homo sapiens_hsa042600.75649415
75Insulin signaling pathway_Homo sapiens_hsa049100.74921408
76Dorso-ventral axis formation_Homo sapiens_hsa043200.74054196
77Circadian rhythm_Homo sapiens_hsa047100.73892028
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.70473631
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69761538
80AMPK signaling pathway_Homo sapiens_hsa041520.69388653
81mRNA surveillance pathway_Homo sapiens_hsa030150.66601964
82Steroid biosynthesis_Homo sapiens_hsa001000.65630327
83Dilated cardiomyopathy_Homo sapiens_hsa054140.63835033
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.62864498
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62794034
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62572215
87Lysine degradation_Homo sapiens_hsa003100.60587819
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60526474
89Vibrio cholerae infection_Homo sapiens_hsa051100.60157370
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59491392
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58140810
92Glucagon signaling pathway_Homo sapiens_hsa049220.57436061
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56986906
94Notch signaling pathway_Homo sapiens_hsa043300.56634319
95Tight junction_Homo sapiens_hsa045300.56426313
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.55721858
97Bile secretion_Homo sapiens_hsa049760.55397569
98Endocytosis_Homo sapiens_hsa041440.54643453
99Rap1 signaling pathway_Homo sapiens_hsa040150.54590546
100Collecting duct acid secretion_Homo sapiens_hsa049660.54263416
101Inositol phosphate metabolism_Homo sapiens_hsa005620.54142078
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53500443
103Fatty acid biosynthesis_Homo sapiens_hsa000610.52597013
104Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52022691
105N-Glycan biosynthesis_Homo sapiens_hsa005100.51802345
106Insulin resistance_Homo sapiens_hsa049310.50637643
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50457314
108Adherens junction_Homo sapiens_hsa045200.50330546
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50097989
110Proteoglycans in cancer_Homo sapiens_hsa052050.49628501
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46992046
112Pancreatic cancer_Homo sapiens_hsa052120.46925406
113Ras signaling pathway_Homo sapiens_hsa040140.46802388
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45500562
115Ovarian steroidogenesis_Homo sapiens_hsa049130.45153078

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