XPC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.01812833
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.59684473
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.59684473
4antigen processing and presentation of endogenous antigen (GO:0019883)4.44586577
5viral transcription (GO:0019083)4.33092654
6negative regulation of phagocytosis (GO:0050765)4.20385266
7antigen processing and presentation via MHC class Ib (GO:0002475)4.17964639
8translational termination (GO:0006415)4.10683637
9killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.07992169
10disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.07992169
11DNA deamination (GO:0045006)3.98629152
12DNA unwinding involved in DNA replication (GO:0006268)3.95275138
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.94604264
14negative regulation of cell killing (GO:0031342)3.94604264
15histone H3-K36 demethylation (GO:0070544)3.91446523
16DNA strand elongation involved in DNA replication (GO:0006271)3.81441857
17telomere maintenance via semi-conservative replication (GO:0032201)3.79445959
18DNA strand elongation (GO:0022616)3.76760432
19positive regulation of B cell differentiation (GO:0045579)3.76283547
20translational elongation (GO:0006414)3.74571710
21definitive hemopoiesis (GO:0060216)3.70931457
22SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.64368451
23COPI coating of Golgi vesicle (GO:0048205)3.61679229
24Golgi transport vesicle coating (GO:0048200)3.61679229
25cotranslational protein targeting to membrane (GO:0006613)3.52655608
26protein targeting to ER (GO:0045047)3.52002994
27positive regulation by symbiont of host defense response (GO:0052509)3.47825388
28modulation by symbiont of host defense response (GO:0052031)3.47825388
29modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.47825388
30modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.47825388
31positive regulation by organism of defense response of other organism involved in symbiotic interact3.47825388
32modulation by symbiont of host immune response (GO:0052553)3.47825388
33mannose metabolic process (GO:0006013)3.46293978
34defense response to fungus (GO:0050832)3.42144540
35pentose-phosphate shunt (GO:0006098)3.39180908
36regulation of RNA export from nucleus (GO:0046831)3.38507903
37negative thymic T cell selection (GO:0045060)3.37357068
38ribosomal small subunit biogenesis (GO:0042274)3.36863986
39regulation of histone H3-K27 methylation (GO:0061085)3.35147801
40positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.34978903
41establishment of protein localization to endoplasmic reticulum (GO:0072599)3.34318837
42protein localization to endoplasmic reticulum (GO:0070972)3.31281524
43nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.30358641
44telomere maintenance via recombination (GO:0000722)3.29757402
45maturation of SSU-rRNA (GO:0030490)3.26281179
46negative T cell selection (GO:0043383)3.25574155
47response to interleukin-15 (GO:0070672)3.24015732
48regulation of B cell differentiation (GO:0045577)3.14728019
49telomere maintenance via telomere lengthening (GO:0010833)3.13918399
50macrophage differentiation (GO:0030225)3.13529392
51regulation of nucleobase-containing compound transport (GO:0032239)3.13315256
52killing of cells of other organism (GO:0031640)3.12244100
53disruption of cells of other organism (GO:0044364)3.12244100
54thymic T cell selection (GO:0045061)3.12070062
55viral life cycle (GO:0019058)3.10894837
56lymphoid progenitor cell differentiation (GO:0002320)3.09823630
57translational initiation (GO:0006413)3.05748130
58detection of molecule of bacterial origin (GO:0032490)3.05309867
59positive regulation of gamma-delta T cell activation (GO:0046645)3.04991157
60negative regulation of erythrocyte differentiation (GO:0045647)3.04836207
61response to laminar fluid shear stress (GO:0034616)2.99924910
62megakaryocyte development (GO:0035855)2.99884558
63mitotic recombination (GO:0006312)2.99489897
64DNA replication initiation (GO:0006270)2.97130716
65cellular protein complex disassembly (GO:0043624)2.97044964
66nucleobase biosynthetic process (GO:0046112)2.96853002
67IMP metabolic process (GO:0046040)2.96365433
68nuclear pore complex assembly (GO:0051292)2.94860192
69IMP biosynthetic process (GO:0006188)2.94793349
70neutrophil mediated immunity (GO:0002446)2.94485282
71NADPH regeneration (GO:0006740)2.94484718
72histone lysine demethylation (GO:0070076)2.93941286
73detection of other organism (GO:0098543)2.88312669
74detection of external biotic stimulus (GO:0098581)2.86299920
75positive thymic T cell selection (GO:0045059)2.85509698
76fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.82529032
77protein localization to endosome (GO:0036010)2.81369552
78protein complex disassembly (GO:0043241)2.80140336
79histone demethylation (GO:0016577)2.79671567
80B cell receptor signaling pathway (GO:0050853)2.79565786
81valine metabolic process (GO:0006573)2.77847491
82angiogenesis involved in wound healing (GO:0060055)2.77514262
83detection of bacterium (GO:0016045)2.77013273
84histone H3-K9 demethylation (GO:0033169)2.75799156
85response to fungus (GO:0009620)2.75390691
86embryonic process involved in female pregnancy (GO:0060136)2.74370483
87nucleotide-excision repair, DNA gap filling (GO:0006297)2.72346978
88T cell selection (GO:0045058)2.72233132
89DNA duplex unwinding (GO:0032508)2.71485086
90antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.70343976
91regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.70160771
92Arp2/3 complex-mediated actin nucleation (GO:0034314)2.70157186
93positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.68948697
94stress fiber assembly (GO:0043149)2.67800836
95DNA geometric change (GO:0032392)2.67582594
96platelet dense granule organization (GO:0060155)2.66825201
97protein localization to kinetochore (GO:0034501)2.66702032
98formation of translation preinitiation complex (GO:0001731)2.64893248
99nuclear-transcribed mRNA catabolic process (GO:0000956)2.64419652
100mitochondrial DNA metabolic process (GO:0032042)2.63041692
101telomere maintenance (GO:0000723)2.61900550
102regulation of gamma-delta T cell differentiation (GO:0045586)2.61390453
103response to muramyl dipeptide (GO:0032495)2.60311956
1043-UTR-mediated mRNA stabilization (GO:0070935)2.59949527
105pentose metabolic process (GO:0019321)2.59532396
106telomere organization (GO:0032200)2.58619836
107macromolecular complex disassembly (GO:0032984)2.57484588
108regulation of extracellular matrix disassembly (GO:0010715)2.56595811
109cellular response to zinc ion (GO:0071294)2.54411351
110mRNA catabolic process (GO:0006402)2.53365186
111RNA catabolic process (GO:0006401)2.52952752
112secretory granule organization (GO:0033363)2.52752383
113purine nucleobase biosynthetic process (GO:0009113)2.51892268
114negative regulation of growth of symbiont in host (GO:0044130)2.50596249
115negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.50596249
116modulation of growth of symbiont involved in interaction with host (GO:0044144)2.50596249
117regulation of growth of symbiont in host (GO:0044126)2.50596249
118COPII vesicle coating (GO:0048208)2.50189303
119hypotonic response (GO:0006971)2.49932237
120histone H4 deacetylation (GO:0070933)2.48553378
121dosage compensation (GO:0007549)2.47991299
122protein dealkylation (GO:0008214)2.47953392
123protein demethylation (GO:0006482)2.47953392
124positive regulation of Cdc42 GTPase activity (GO:0043089)2.47750744
125positive T cell selection (GO:0043368)2.46791439
126ribosomal large subunit biogenesis (GO:0042273)2.45613995
127retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.42910488
128cellular response to interleukin-15 (GO:0071350)2.42039295
129translesion synthesis (GO:0019985)2.41617989
130necroptotic process (GO:0070266)2.41502437
131T cell homeostasis (GO:0043029)2.40975790
132regulation of type I interferon-mediated signaling pathway (GO:0060338)2.39520877
133regulation of interferon-beta biosynthetic process (GO:0045357)2.38951474
134DNA topological change (GO:0006265)2.38686816
135ncRNA 3-end processing (GO:0043628)2.38496023
136positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.37068269
137detection of biotic stimulus (GO:0009595)2.37039432
138regulation of ARF GTPase activity (GO:0032312)2.36781918
139regulation of necroptotic process (GO:0060544)2.36413779
140negative regulation of RNA splicing (GO:0033119)2.34846057
141regulation of B cell receptor signaling pathway (GO:0050855)2.34814734
142leukocyte aggregation (GO:0070486)2.34752531
143purine nucleobase metabolic process (GO:0006144)2.34120057
144glucose catabolic process (GO:0006007)2.33723085
145negative regulation of lymphocyte mediated immunity (GO:0002707)2.33381843
146response to host (GO:0075136)2.32493170
147response to host defenses (GO:0052200)2.32493170
148response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.32493170
149telomere maintenance via telomerase (GO:0007004)2.31716007
150regulation of gamma-delta T cell activation (GO:0046643)2.30976857
151response to interferon-beta (GO:0035456)2.29539368
152cellular hyperosmotic response (GO:0071474)2.29314702
153negative regulation of glycoprotein biosynthetic process (GO:0010561)2.29212075
154skin morphogenesis (GO:0043589)2.28015156
155regulation of translational fidelity (GO:0006450)2.27983223
156regulation of chromatin binding (GO:0035561)2.27768687
157purine-containing compound salvage (GO:0043101)2.27631492
158cellular extravasation (GO:0045123)2.27453583
159purine nucleotide salvage (GO:0032261)2.27299603
160endosome to pigment granule transport (GO:0043485)2.25646978
161endosome to melanosome transport (GO:0035646)2.25646978
162positive regulation of blood vessel endothelial cell migration (GO:0043536)2.25469678
163positive regulation of receptor recycling (GO:0001921)2.25328172
164negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.24917748
165spliceosomal tri-snRNP complex assembly (GO:0000244)2.22632405
166positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.22529843
167vesicle coating (GO:0006901)2.22306325
168JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.21328668
169negative regulation of viral release from host cell (GO:1902187)2.19888265
170regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.18934171
171protein export from nucleus (GO:0006611)2.17616611
172planar cell polarity pathway involved in neural tube closure (GO:0090179)2.17470408
173histone H3-K4 trimethylation (GO:0080182)2.16313792
174macrophage activation involved in immune response (GO:0002281)2.15818923
175pinocytosis (GO:0006907)2.14779903
176negative regulation of innate immune response (GO:0045824)2.14335300
177retrograde transport, endosome to Golgi (GO:0042147)2.13880359
178cellular response to virus (GO:0098586)2.12915260
179regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.12386579
180type I interferon signaling pathway (GO:0060337)2.11194814
181cellular response to type I interferon (GO:0071357)2.11194814
182negative regulation of leukocyte mediated immunity (GO:0002704)2.11175506
183response to host immune response (GO:0052572)2.10844691

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.03503223
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.35695904
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.32816717
4MYC_22102868_ChIP-Seq_BL_Human2.78881439
5VDR_21846776_ChIP-Seq_THP-1_Human2.75462064
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.75388484
7SCL_19346495_ChIP-Seq_HPC-7_Human2.67701192
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.63004778
9SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.54919795
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.45403092
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.40788292
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.40283506
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.31445817
14TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.25623201
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.22965027
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.22633030
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16063176
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.15193863
19FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.01663399
20KDM2B_26808549_Chip-Seq_SUP-B15_Human1.98916515
21* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.97469298
22MYC_18358816_ChIP-ChIP_MESCs_Mouse1.97401566
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.97127621
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.94807352
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.92431765
26KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.87450755
27SPI1_23547873_ChIP-Seq_NB4_Human1.85227703
28SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.84524214
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.82804681
30KDM2B_26808549_Chip-Seq_DND41_Human1.82372296
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.82195136
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.80638721
33ERG_20887958_ChIP-Seq_HPC-7_Mouse1.79706951
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.72883110
35CIITA_25753668_ChIP-Seq_RAJI_Human1.72021174
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.70956030
37STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.70853637
38* MAF_26560356_Chip-Seq_TH1_Human1.69774775
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.68653869
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.67692759
41VDR_24763502_ChIP-Seq_THP-1_Human1.65850121
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.65121268
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64072047
44XRN2_22483619_ChIP-Seq_HELA_Human1.62708180
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62071725
46RACK7_27058665_Chip-Seq_MCF-7_Human1.61670237
47NCOR1_26117541_ChIP-Seq_K562_Human1.61211104
48FOXP3_21729870_ChIP-Seq_TREG_Human1.60123694
49* UTX_26944678_Chip-Seq_JUKART_Human1.59634691
50VDR_23849224_ChIP-Seq_CD4+_Human1.56953513
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.56357263
52EST1_17652178_ChIP-ChIP_JURKAT_Human1.56342682
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.55375538
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.54450389
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54038500
56TCF7_22412390_ChIP-Seq_EML_Mouse1.52849471
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52804211
58* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.52441065
59MYB_26560356_Chip-Seq_TH2_Human1.52380214
60ETS1_20019798_ChIP-Seq_JURKAT_Human1.52163131
61STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50420045
62KDM2B_26808549_Chip-Seq_JURKAT_Human1.49322913
63CLOCK_20551151_ChIP-Seq_293T_Human1.49013988
64* TP53_22127205_ChIP-Seq_IMR90_Human1.48991991
65GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.48940680
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.47515203
67* MYB_26560356_Chip-Seq_TH1_Human1.47121049
68SPI1_23127762_ChIP-Seq_K562_Human1.46450955
69LXR_22292898_ChIP-Seq_THP-1_Human1.46256192
70BP1_19119308_ChIP-ChIP_Hs578T_Human1.46181584
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45894500
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.45611280
73GABP_17652178_ChIP-ChIP_JURKAT_Human1.45518269
74CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.44380849
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.44140668
76* E2F1_21310950_ChIP-Seq_MCF-7_Human1.41428227
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.39834408
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38818788
79* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.38503316
80RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.38175479
81* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36186876
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36061081
83PPARA_22158963_ChIP-Seq_LIVER_Mouse1.35863552
84KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.35577024
85STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.35182385
86P300_27058665_Chip-Seq_ZR-75-30cells_Human1.33880179
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33572628
88SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32763286
89NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32618929
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31849879
91GATA1_22025678_ChIP-Seq_K562_Human1.31195572
92NOTCH1_21737748_ChIP-Seq_TLL_Human1.30508974
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29476632
94IRF8_21731497_ChIP-ChIP_J774_Mouse1.28727069
95LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.28509968
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28267601
97GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27012078
98STAT4_19710469_ChIP-ChIP_TH1__Mouse1.26162612
99E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26118302
100RXR_22158963_ChIP-Seq_LIVER_Mouse1.26031130
101CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24796187
102AR_21909140_ChIP-Seq_LNCAP_Human1.24620722
103IRF8_27001747_Chip-Seq_BMDM_Mouse1.24076842
104SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23644263
105ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20913109
106PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.17992780
107GABP_19822575_ChIP-Seq_HepG2_Human1.17268229
108* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17005410
109KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16473008
110RUNX_20019798_ChIP-Seq_JUKART_Human1.15436385
111ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14823311
112MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13376042
113E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13325907
114SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13059396
115* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12757704
116FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12679615
117FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.12635041
118ATF3_27146783_Chip-Seq_COLON_Human1.12415243
119KDM2B_26808549_Chip-Seq_K562_Human1.12191978
120PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12055777
121RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11871553
122LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11854729
123STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11331406
124DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10875612
125TTF2_22483619_ChIP-Seq_HELA_Human1.10703395
126EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09899115
127GATA1_19941827_ChIP-Seq_MEL_Mouse1.09140688
128WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08120880
129* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07720193
130TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06543835
131CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06298796
132NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.04521422
133KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04010874
134POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03031661
135KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02986646
136PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02464403
137TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01899339
138MAF_26560356_Chip-Seq_TH2_Human1.01649499
139NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.01422054
140DCP1A_22483619_ChIP-Seq_HELA_Human0.99457864
141ELK3_25401928_ChIP-Seq_HUVEC_Human0.97390339
142CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96976401
143KDM5A_27292631_Chip-Seq_BREAST_Human0.96709719
144CHD1_26751641_Chip-Seq_LNCaP_Human0.96566732
145SRF_21415370_ChIP-Seq_HL-1_Mouse0.95957212
146FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.95592824
147GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95290612
148ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93504493
149TFEB_21752829_ChIP-Seq_HELA_Human0.92309226

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system4.17027274
2MP0003705_abnormal_hypodermis_morpholog3.91650550
3MP0008438_abnormal_cutaneous_collagen3.16934833
4MP0008260_abnormal_autophagy2.74050006
5MP0005397_hematopoietic_system_phenotyp2.62612152
6MP0001545_abnormal_hematopoietic_system2.62612152
7MP0002166_altered_tumor_susceptibility2.45266328
8MP0004808_abnormal_hematopoietic_stem2.45007311
9MP0010094_abnormal_chromosome_stability2.42931245
10MP0001835_abnormal_antigen_presentation2.38353254
11MP0003693_abnormal_embryo_hatching2.35546480
12MP0009278_abnormal_bone_marrow2.30009546
13MP0005451_abnormal_body_composition2.26470368
14MP0001958_emphysema2.25506480
15MP0009785_altered_susceptibility_to2.17793454
16MP0005464_abnormal_platelet_physiology2.12638623
17MP0000465_gastrointestinal_hemorrhage2.05929668
18MP0003763_abnormal_thymus_physiology2.05410291
19MP0003436_decreased_susceptibility_to2.03010705
20MP0005360_urolithiasis2.02158323
21MP0008057_abnormal_DNA_replication2.01702682
22MP0000685_abnormal_immune_system1.94804668
23MP0005365_abnormal_bile_salt1.94499588
24MP0005174_abnormal_tail_pigmentation1.94369385
25MP0000490_abnormal_crypts_of1.94209269
26MP0002139_abnormal_hepatobiliary_system1.93250722
27MP0003724_increased_susceptibility_to1.91796152
28MP0003111_abnormal_nucleus_morphology1.84991213
29MP0003077_abnormal_cell_cycle1.84711982
30MP0003091_abnormal_cell_migration1.82543938
31MP0005025_abnormal_response_to1.81587841
32MP0002398_abnormal_bone_marrow1.77124981
33MP0002132_abnormal_respiratory_system1.74615925
34MP0001348_abnormal_lacrimal_gland1.73463199
35MP0004957_abnormal_blastocyst_morpholog1.71046687
36MP0010155_abnormal_intestine_physiology1.66197280
37MP0005058_abnormal_lysosome_morphology1.66096869
38MP0000689_abnormal_spleen_morphology1.65306818
39MP0001800_abnormal_humoral_immune1.63958637
40MP0003566_abnormal_cell_adhesion1.63474147
41MP0005075_abnormal_melanosome_morpholog1.62433666
42MP0002419_abnormal_innate_immunity1.61547219
43MP0002722_abnormal_immune_system1.61505280
44MP0010352_gastrointestinal_tract_polyps1.60755318
45MP0002006_tumorigenesis1.60409292
46MP0002420_abnormal_adaptive_immunity1.58307695
47MP0008007_abnormal_cellular_replicative1.57670640
48MP0001853_heart_inflammation1.57640621
49MP0009840_abnormal_foam_cell1.57079554
50MP0001873_stomach_inflammation1.57008345
51MP0001819_abnormal_immune_cell1.54442249
52MP0003191_abnormal_cellular_cholesterol1.54160925
53MP0000716_abnormal_immune_system1.50161383
54MP0005671_abnormal_response_to1.47661966
55MP0002429_abnormal_blood_cell1.46687930
56MP0002452_abnormal_antigen_presenting1.46141639
57MP0008058_abnormal_DNA_repair1.46126495
58MP0005503_abnormal_tendon_morphology1.45455666
59MP0003866_abnormal_defecation1.44252818
60MP0003300_gastrointestinal_ulcer1.43699586
61MP0001849_ear_inflammation1.43680644
62MP0004272_abnormal_basement_membrane1.43574269
63MP0002723_abnormal_immune_serum1.42773680
64MP0003279_aneurysm1.39307450
65* MP0002019_abnormal_tumor_incidence1.37063458
66MP0000703_abnormal_thymus_morphology1.35966862
67MP0002405_respiratory_system_inflammati1.34615374
68MP0010307_abnormal_tumor_latency1.34437544
69MP0005275_abnormal_skin_tensile1.32031205
70MP0010368_abnormal_lymphatic_system1.30125286
71MP0003303_peritoneal_inflammation1.28409798
72MP0005000_abnormal_immune_tolerance1.27101776
73MP0009333_abnormal_splenocyte_physiolog1.26877102
74MP0001845_abnormal_inflammatory_respons1.24130122
75MP0008875_abnormal_xenobiotic_pharmacok1.23191771
76MP0002877_abnormal_melanocyte_morpholog1.22880636
77MP0005085_abnormal_gallbladder_physiolo1.20897084
78MP0000858_altered_metastatic_potential1.16947322
79MP0002060_abnormal_skin_morphology1.16866856
80MP0002095_abnormal_skin_pigmentation1.15487396
81MP0006054_spinal_hemorrhage1.13513878
82MP0003656_abnormal_erythrocyte_physiolo1.13095489
83MP0001533_abnormal_skeleton_physiology1.12900415
84MP0000767_abnormal_smooth_muscle1.12730292
85MP0008469_abnormal_protein_level1.12218555
86MP0000015_abnormal_ear_pigmentation1.12068873
87MP0004264_abnormal_extraembryonic_tissu1.10710066
88MP0005257_abnormal_intraocular_pressure1.08606634
89MP0003806_abnormal_nucleotide_metabolis1.06720428
90MP0001915_intracranial_hemorrhage1.06677598
91* MP0005621_abnormal_cell_physiology1.05983846
92MP0003453_abnormal_keratinocyte_physiol1.05683240
93MP0010329_abnormal_lipoprotein_level1.04536052
94MP0001790_abnormal_immune_system1.04204690
95MP0005387_immune_system_phenotype1.04204690
96MP0001243_abnormal_dermal_layer1.03641645
97MP0000609_abnormal_liver_physiology1.03561677
98MP0001542_abnormal_bone_strength1.02261699
99MP0004883_abnormal_blood_vessel1.02041082
100MP0005319_abnormal_enzyme/_coenzyme1.01117339
101MP0005409_darkened_coat_color1.00058235
102MP0000598_abnormal_liver_morphology0.95766145
103MP0002009_preneoplasia0.95491830
104MP0003943_abnormal_hepatobiliary_system0.94069701
105MP0005220_abnormal_exocrine_pancreas0.93700136
106MP0002998_abnormal_bone_remodeling0.93497174
107* MP0000313_abnormal_cell_death0.93225151
108MP0009763_increased_sensitivity_to0.93055507
109MP0001986_abnormal_taste_sensitivity0.91774783
110MP0003183_abnormal_peptide_metabolism0.91123166
111MP0001661_extended_life_span0.91034563
112MP0005164_abnormal_response_to0.88035783
113MP0004381_abnormal_hair_follicle0.87672821
114MP0000477_abnormal_intestine_morphology0.86876061
115MP0004233_abnormal_muscle_weight0.86397711
116MP0003786_premature_aging0.85989162
117MP0001730_embryonic_growth_arrest0.85561609
118MP0005023_abnormal_wound_healing0.85472469
119MP0002295_abnormal_pulmonary_circulatio0.84123585
120MP0003828_pulmonary_edema0.83969724
121MP0003172_abnormal_lysosome_physiology0.83627012
122MP0008873_increased_physiological_sensi0.83585155
123MP0002148_abnormal_hypersensitivity_rea0.83390994
124MP0005390_skeleton_phenotype0.82699663
125MP0000343_altered_response_to0.82453851
126MP0009643_abnormal_urine_homeostasis0.81769616
127MP0000371_diluted_coat_color0.81685753
128MP0003252_abnormal_bile_duct0.81331301
129MP0006036_abnormal_mitochondrial_physio0.81271198
130MP0000350_abnormal_cell_proliferation0.80465466
131MP0001879_abnormal_lymphatic_vessel0.78780276
132MP0005408_hypopigmentation0.78211640
133* MP0005384_cellular_phenotype0.78081300
134MP0000604_amyloidosis0.77439168
135MP0003795_abnormal_bone_structure0.76783304
136MP0003567_abnormal_fetal_cardiomyocyte0.76709370
137MP0005076_abnormal_cell_differentiation0.76409879
138MP0002089_abnormal_postnatal_growth/wei0.75195807
139MP0002933_joint_inflammation0.74646630
140MP0005584_abnormal_enzyme/coenzyme_acti0.74339858
141* MP0003186_abnormal_redox_activity0.73086354
142MP0009765_abnormal_xenobiotic_induced0.72361353
143MP0009379_abnormal_foot_pigmentation0.72129019
144MP0004947_skin_inflammation0.71507616
145MP0003221_abnormal_cardiomyocyte_apopto0.71132672

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)5.24772402
2Reticulocytopenia (HP:0001896)4.30442482
3IgM deficiency (HP:0002850)4.22924549
4Protrusio acetabuli (HP:0003179)4.16035457
5Chronic otitis media (HP:0000389)3.77906846
6Acute lymphatic leukemia (HP:0006721)3.46505823
7Aplastic anemia (HP:0001915)3.35569618
8Recurrent abscess formation (HP:0002722)3.26410817
9Premature rupture of membranes (HP:0001788)3.26180835
10Recurrent bronchitis (HP:0002837)3.19765330
11Spontaneous hematomas (HP:0007420)3.19051744
12Abnormality of B cell number (HP:0010975)3.17011904
13B lymphocytopenia (HP:0010976)3.17011904
14Abnormality of cells of the erythroid lineage (HP:0012130)3.16673773
15Abnormality of T cell physiology (HP:0011840)3.15163818
16Cervical subluxation (HP:0003308)3.10372924
17Eczematoid dermatitis (HP:0000976)3.10117376
18Myositis (HP:0100614)2.94972579
19Abnormal number of erythroid precursors (HP:0012131)2.93341408
20Elevated erythrocyte sedimentation rate (HP:0003565)2.92675345
21Dilatation of the ascending aorta (HP:0005111)2.88341784
22Recurrent bacterial skin infections (HP:0005406)2.86895107
23Abnormality of the nasal mucosa (HP:0000433)2.81689218
24Aortic aneurysm (HP:0004942)2.81633916
2511 pairs of ribs (HP:0000878)2.74810436
26Epistaxis (HP:0000421)2.72951315
27Vascular tortuosity (HP:0004948)2.70847901
28Abnormal platelet function (HP:0011869)2.66592997
29Impaired platelet aggregation (HP:0003540)2.66592997
30Acute myeloid leukemia (HP:0004808)2.65681021
31Nasal polyposis (HP:0100582)2.64651686
32Abnormal delayed hypersensitivity skin test (HP:0002963)2.64320817
33Prolonged bleeding time (HP:0003010)2.61522560
34Abnormality of T cells (HP:0002843)2.59467467
35Vertebral compression fractures (HP:0002953)2.58487992
36Meningitis (HP:0001287)2.58364345
37Gastrointestinal inflammation (HP:0004386)2.47461185
38Petechiae (HP:0000967)2.45676475
39Abnormality of pyrimidine metabolism (HP:0004353)2.44042889
40Abnormality of the prostate (HP:0008775)2.43017589
41Chronic obstructive pulmonary disease (HP:0006510)2.42655358
42Obstructive lung disease (HP:0006536)2.42655358
43Recurrent fungal infections (HP:0002841)2.41544523
44Reduced antithrombin III activity (HP:0001976)2.40421889
45Recurrent gram-negative bacterial infections (HP:0005420)2.40173483
46Recurrent viral infections (HP:0004429)2.40002271
47Joint hemorrhage (HP:0005261)2.39358467
48Biconcave vertebral bodies (HP:0004586)2.37467217
49Peritonitis (HP:0002586)2.37364981
50Disproportionate tall stature (HP:0001519)2.36813555
51T lymphocytopenia (HP:0005403)2.35625099
52Panhypogammaglobulinemia (HP:0003139)2.35406417
53Arterial tortuosity (HP:0005116)2.34231708
54Aortic dissection (HP:0002647)2.33252370
55Periodontitis (HP:0000704)2.33065235
56Volvulus (HP:0002580)2.30694170
57Myelodysplasia (HP:0002863)2.28693508
58Thin bony cortex (HP:0002753)2.25905016
59Pallor (HP:0000980)2.25563463
60Emphysema (HP:0002097)2.24892352
61Mitral valve prolapse (HP:0001634)2.24607319
62Abnormality of the fingertips (HP:0001211)2.24417273
63Chronic mucocutaneous candidiasis (HP:0002728)2.22773875
64Recurrent cutaneous fungal infections (HP:0011370)2.22773875
65Bladder diverticulum (HP:0000015)2.21976688
66Hyperacusis (HP:0010780)2.18515824
67Cellulitis (HP:0100658)2.17874735
68Metaphyseal cupping (HP:0003021)2.17817304
69Gingivitis (HP:0000230)2.17459534
70Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.16537769
71Aneurysm (HP:0002617)2.15667051
72Macrocytic anemia (HP:0001972)2.14567389
73Inflammation of the large intestine (HP:0002037)2.12497527
74Chest pain (HP:0100749)2.11037451
75Joint laxity (HP:0001388)2.11031932
76Gastrointestinal infarctions (HP:0005244)2.10408181
77Wormian bones (HP:0002645)2.09942947
78Ankle contracture (HP:0006466)2.05521127
79Amaurosis fugax (HP:0100576)2.05510515
80Granulocytopenia (HP:0001913)2.04858309
81Spinal cord lesions (HP:0100561)2.04181461
82Syringomyelia (HP:0003396)2.04181461
83Albinism (HP:0001022)2.04146622
84Abnormality of T cell number (HP:0011839)2.04005814
85Pancytopenia (HP:0001876)2.01975899
86Recurrent skin infections (HP:0001581)2.01254238
87Hypochromic anemia (HP:0001931)2.01105638
88Lymphoma (HP:0002665)2.00909841
89Microcytic anemia (HP:0001935)2.00573411
90Abnormality of the peritoneum (HP:0002585)2.00151350
91Lymphopenia (HP:0001888)1.97148116
92Mediastinal lymphadenopathy (HP:0100721)1.96942746
93Papilledema (HP:0001085)1.96840733
94Dislocated radial head (HP:0003083)1.95634331
95Cerebral aneurysm (HP:0004944)1.95454460
96Flat acetabular roof (HP:0003180)1.94351015
97Viral hepatitis (HP:0006562)1.93747336
98Blue sclerae (HP:0000592)1.93605114
99Abnormality of chromosome stability (HP:0003220)1.92990324
100Chromsome breakage (HP:0040012)1.92713992
101Pustule (HP:0200039)1.92374951
102Abnormality of cells of the lymphoid lineage (HP:0012140)1.91630953
103Colitis (HP:0002583)1.91161369
104Absent frontal sinuses (HP:0002688)1.91027319
105Genu recurvatum (HP:0002816)1.90439181
106Neutropenia (HP:0001875)1.90063500
107Mitral regurgitation (HP:0001653)1.89254615
108Interstitial pulmonary disease (HP:0006530)1.89042833
109* Entropion (HP:0000621)1.88716827
110Thoracic kyphosis (HP:0002942)1.88468802
111Abnormality of fatty-acid metabolism (HP:0004359)1.88193125
112Generalized aminoaciduria (HP:0002909)1.87646137
113Hemoptysis (HP:0002105)1.87130752
114Long palpebral fissure (HP:0000637)1.86707968
115Abnormality of the thoracic spine (HP:0100711)1.85955477
116Abnormal platelet volume (HP:0011876)1.85703548
117Abnormality of oral frenula (HP:0000190)1.85358118
118Oral leukoplakia (HP:0002745)1.84137018
119Bone marrow hypocellularity (HP:0005528)1.83330666
120Skin ulcer (HP:0200042)1.82811460
121Ulnar bowing (HP:0003031)1.82402864
122Abnormality of skull ossification (HP:0002703)1.82036201
123Abnormality of the common coagulation pathway (HP:0010990)1.81725466
124Bronchitis (HP:0012387)1.81011276
125Asymmetry of the thorax (HP:0001555)1.80986371
126Vacuolated lymphocytes (HP:0001922)1.80890562
127Long toe (HP:0010511)1.80723282
128Deep venous thrombosis (HP:0002625)1.80684291
129Abnormality of aromatic amino acid family metabolism (HP:0004338)1.80019268
130Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.79352199
131Abnormality of the radial head (HP:0003995)1.77907456
132Colon cancer (HP:0003003)1.77316156
133Encephalitis (HP:0002383)1.76718809
134Spastic diplegia (HP:0001264)1.76068572
135Gingival bleeding (HP:0000225)1.75817894
136* Basal cell carcinoma (HP:0002671)1.75628642
137Hypertensive crisis (HP:0100735)1.75498210
138Atelectasis (HP:0100750)1.75186958
139Dicarboxylic aciduria (HP:0003215)1.75177618
140Abnormality of dicarboxylic acid metabolism (HP:0010995)1.75177618
141Abnormality of macrophages (HP:0004311)1.74714262
142Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.74455440
143Thyroiditis (HP:0100646)1.74076554
144Abnormality of monocarboxylic acid metabolism (HP:0010996)1.74057055
145Subacute progressive viral hepatitis (HP:0006572)1.73926237
146Obstructive sleep apnea (HP:0002870)1.73693965
147Increased IgE level (HP:0003212)1.73331582
148Increased connective tissue (HP:0009025)1.72805547
149Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.72717841
150IgG deficiency (HP:0004315)1.72395661
151Chronic sinusitis (HP:0011109)1.71529273
152Spondylolisthesis (HP:0003302)1.71311695
153Osteomyelitis (HP:0002754)1.70928892
154Thrombophlebitis (HP:0004418)1.70915536
155Bowel diverticulosis (HP:0005222)1.69915457
156Spinal rigidity (HP:0003306)1.69738841
157Prolonged partial thromboplastin time (HP:0003645)1.69649048
158Hypoplasia of the thymus (HP:0000778)1.69578271
159Gastrointestinal stroma tumor (HP:0100723)1.69572727
160IgA deficiency (HP:0002720)1.69477036
161Abnormality of reticulocytes (HP:0004312)1.69339910
162Absent thumb (HP:0009777)1.69058458
163Abnormality of the acetabulum (HP:0003170)1.68500165
164Broad palm (HP:0001169)1.68042367
165Ankyloglossia (HP:0010296)1.67198061
166Vertebral arch anomaly (HP:0008438)1.66832072
167Abnormal vertebral ossification (HP:0100569)1.66762477
168Abnormal foot bone ossification (HP:0010675)1.65883195
169Soft skin (HP:0000977)1.63730416
170Patellar dislocation (HP:0002999)1.63499012
171Hepatitis (HP:0012115)1.63126221
172Increased variability in muscle fiber diameter (HP:0003557)1.62020898
173Reticulocytosis (HP:0001923)1.61224728
174Long eyelashes (HP:0000527)1.60709341
175Persistence of primary teeth (HP:0006335)1.60623664
176Sparse lateral eyebrow (HP:0005338)1.60583340
177Premature skin wrinkling (HP:0100678)1.59867157

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FLT34.15160033
2EEF2K3.47325686
3PKN23.33027069
4SMG13.08582566
5KIT2.95948135
6MAP4K12.94198532
7CDK122.72436078
8PRPF4B2.70414242
9MAP2K32.32736927
10TEC2.29534903
11BTK2.16893322
12WEE12.10283897
13CSF1R2.10121377
14TGFBR12.02387406
15RIPK42.01170438
16STK162.01116979
17TAOK31.90196600
18RPS6KB21.86155914
19ACVR1B1.84356368
20ICK1.81271679
21PDGFRA1.76239698
22TRIB31.72139407
23MARK21.63907962
24BCKDK1.60157635
25KSR21.54652032
26CDC71.51295906
27ZAP701.50503399
28ERN11.48873892
29NEK91.48840118
30MAPKAPK31.48064069
31MAP3K131.47794885
32PRKD21.46118660
33CDK41.42391116
34NME21.41697792
35GRK61.41115453
36KDR1.40565672
37MAP3K61.37065406
38LRRK21.32075511
39BUB11.25601653
40BRSK21.24992272
41PIM11.22936090
42PIM21.22615277
43NEK21.21884538
44PAK41.20470922
45PASK1.19947931
46JAK11.18566148
47IRAK41.16617958
48STK101.14908881
49ATR1.14080679
50MTOR1.13551551
51TGFBR21.11746608
52EIF2AK31.11094810
53MAP3K101.10777663
54AKT31.08151015
55CDK71.07923884
56DYRK31.07722092
57FES1.06247210
58SYK1.04241132
59PDGFRB1.03636020
60MATK1.03438892
61ITK1.02491898
62TYK21.01740983
63TBK11.01533060
64BRD41.00103624
65MAP3K20.99295926
66TIE10.98839932
67PTK60.97185216
68FGFR40.96660245
69MAP3K140.94860903
70HIPK20.94304231
71JAK30.94302947
72TTN0.93952682
73WNK10.92987635
74CDC42BPA0.92685431
75RET0.92118568
76MAP3K10.90401381
77CDK60.89763786
78STK380.87577652
79STK40.86193210
80SRPK10.85655310
81CLK10.84253780
82RPS6KA60.83318871
83MAPK110.83109269
84TRPM70.80769372
85RPS6KL10.78839553
86RPS6KC10.78839553
87FGR0.78442022
88SCYL20.76629522
89RPS6KA40.75705447
90TSSK60.75621196
91CDK190.75510475
92BLK0.75475956
93LCK0.74903805
94MAPK40.72993088
95MELK0.72960057
96PTK2B0.72524733
97PTK20.72481581
98HCK0.72348224
99MAP2K60.71077447
100VRK10.67667072
101TXK0.67551422
102MKNK10.66596508
103LYN0.65456537
104SIK30.65113428
105YES10.64261594
106CAMK1G0.63474066
107KSR10.62713397
108BMX0.62186920
109EIF2AK10.61548589
110TESK20.60213241
111IKBKE0.60207490
112AURKB0.58582379
113DAPK10.58501936
114MARK30.57853233
115TNK20.56842011
116MAP3K80.56541801
117SGK30.56516174
118PIK3CG0.55947607
119NEK60.55946149
120TYRO30.55685351
121ILK0.55542510
122CHUK0.55465645
123PDPK10.51916559
124RPS6KB10.51584023
125CSK0.50764507
126MKNK20.50527936
127EPHB10.49673288
128PDK10.48491506
129MAP3K110.48166584
130NLK0.47497696
131MAP3K70.46858019
132SIK10.46352936
133TTK0.45702452
134JAK20.45669971
135PLK10.45471306
136RIPK10.45179446
137MAP3K30.44684793
138IKBKB0.43886241
139FGFR30.43344888
140RAF10.43327917
141RPS6KA20.42710572
142TLK10.42214017
143STK240.39633371
144MYLK0.38550109
145DYRK1B0.36424410
146CCNB10.35195346

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.16837517
2Mismatch repair_Homo sapiens_hsa034303.46370419
3Ribosome_Homo sapiens_hsa030103.08565384
4Base excision repair_Homo sapiens_hsa034102.70512994
5Non-homologous end-joining_Homo sapiens_hsa034502.27417269
6Homologous recombination_Homo sapiens_hsa034402.26642487
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.05517817
8Spliceosome_Homo sapiens_hsa030401.93969044
9Primary immunodeficiency_Homo sapiens_hsa053401.93304311
10Non-small cell lung cancer_Homo sapiens_hsa052231.89657307
11Pentose phosphate pathway_Homo sapiens_hsa000301.76655440
12Primary bile acid biosynthesis_Homo sapiens_hsa001201.73795863
13One carbon pool by folate_Homo sapiens_hsa006701.65792986
14* Nucleotide excision repair_Homo sapiens_hsa034201.64564475
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.63811366
16Pyrimidine metabolism_Homo sapiens_hsa002401.61751244
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60018575
18Pancreatic cancer_Homo sapiens_hsa052121.55679405
19Caffeine metabolism_Homo sapiens_hsa002321.55265108
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.54593681
21Selenocompound metabolism_Homo sapiens_hsa004501.53757797
22mTOR signaling pathway_Homo sapiens_hsa041501.51438789
23Endometrial cancer_Homo sapiens_hsa052131.49770423
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.48749679
25Hepatitis B_Homo sapiens_hsa051611.46904462
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.45542856
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.44649534
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.41775723
29T cell receptor signaling pathway_Homo sapiens_hsa046601.39719246
30Cell cycle_Homo sapiens_hsa041101.36136507
31VEGF signaling pathway_Homo sapiens_hsa043701.35709469
32Antigen processing and presentation_Homo sapiens_hsa046121.35398596
33Prostate cancer_Homo sapiens_hsa052151.29759813
34Inositol phosphate metabolism_Homo sapiens_hsa005621.27584162
35Apoptosis_Homo sapiens_hsa042101.27000435
36Leishmaniasis_Homo sapiens_hsa051401.24493264
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.23938410
38Hepatitis C_Homo sapiens_hsa051601.22746073
39Fanconi anemia pathway_Homo sapiens_hsa034601.21955795
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.21181424
41Fatty acid degradation_Homo sapiens_hsa000711.19783723
42Prolactin signaling pathway_Homo sapiens_hsa049171.17272199
43Biosynthesis of amino acids_Homo sapiens_hsa012301.15980447
44Herpes simplex infection_Homo sapiens_hsa051681.14892842
45Toll-like receptor signaling pathway_Homo sapiens_hsa046201.14462512
46Sulfur relay system_Homo sapiens_hsa041221.13959626
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11719342
48Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10943193
49Small cell lung cancer_Homo sapiens_hsa052221.09780888
50RNA transport_Homo sapiens_hsa030131.08711653
51Neurotrophin signaling pathway_Homo sapiens_hsa047221.08447174
52Renal cell carcinoma_Homo sapiens_hsa052111.08328382
53Toxoplasmosis_Homo sapiens_hsa051451.08276139
54Colorectal cancer_Homo sapiens_hsa052101.08250438
55Proteoglycans in cancer_Homo sapiens_hsa052051.07817259
56Thyroid hormone signaling pathway_Homo sapiens_hsa049191.07601416
57Glycosaminoglycan degradation_Homo sapiens_hsa005311.07014991
58Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05736834
59RNA degradation_Homo sapiens_hsa030181.05403901
60Choline metabolism in cancer_Homo sapiens_hsa052311.03625234
61ABC transporters_Homo sapiens_hsa020101.03084835
62Lysine degradation_Homo sapiens_hsa003101.01394171
63Viral myocarditis_Homo sapiens_hsa054161.01111394
64MicroRNAs in cancer_Homo sapiens_hsa052061.00744707
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00617215
66RNA polymerase_Homo sapiens_hsa030201.00223846
67Peroxisome_Homo sapiens_hsa041460.99790945
68Other glycan degradation_Homo sapiens_hsa005110.99613584
69Bladder cancer_Homo sapiens_hsa052190.99454036
70N-Glycan biosynthesis_Homo sapiens_hsa005100.98898148
71B cell receptor signaling pathway_Homo sapiens_hsa046620.98849304
72Focal adhesion_Homo sapiens_hsa045100.97097578
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96915325
74Glioma_Homo sapiens_hsa052140.96712209
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95496143
76Adherens junction_Homo sapiens_hsa045200.94677357
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.94211444
78FoxO signaling pathway_Homo sapiens_hsa040680.94026174
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93625626
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92717130
81Autoimmune thyroid disease_Homo sapiens_hsa053200.92576265
82Allograft rejection_Homo sapiens_hsa053300.92430681
83Acute myeloid leukemia_Homo sapiens_hsa052210.92410457
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92283565
85Tuberculosis_Homo sapiens_hsa051520.91789021
86TNF signaling pathway_Homo sapiens_hsa046680.91705191
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91379157
88ErbB signaling pathway_Homo sapiens_hsa040120.91085648
89Glutathione metabolism_Homo sapiens_hsa004800.90722906
90Carbon metabolism_Homo sapiens_hsa012000.89872838
91Folate biosynthesis_Homo sapiens_hsa007900.89580430
92Starch and sucrose metabolism_Homo sapiens_hsa005000.88954840
93Malaria_Homo sapiens_hsa051440.86696319
94Chemokine signaling pathway_Homo sapiens_hsa040620.85359361
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.84218264
96Galactose metabolism_Homo sapiens_hsa000520.84019665
97Hematopoietic cell lineage_Homo sapiens_hsa046400.83920694
98Amoebiasis_Homo sapiens_hsa051460.83727670
99Tryptophan metabolism_Homo sapiens_hsa003800.83676362
100Endocytosis_Homo sapiens_hsa041440.83396560
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.82760997
102Proteasome_Homo sapiens_hsa030500.81852513
103Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81475320
104Graft-versus-host disease_Homo sapiens_hsa053320.81154380
105Insulin resistance_Homo sapiens_hsa049310.80028376
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78448741
107Insulin signaling pathway_Homo sapiens_hsa049100.78187792
108beta-Alanine metabolism_Homo sapiens_hsa004100.75529104
109Systemic lupus erythematosus_Homo sapiens_hsa053220.73712394
110p53 signaling pathway_Homo sapiens_hsa041150.71772349
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71492140
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.71386282
113Legionellosis_Homo sapiens_hsa051340.71138752
114Prion diseases_Homo sapiens_hsa050200.71088842
115HIF-1 signaling pathway_Homo sapiens_hsa040660.70933507
116Measles_Homo sapiens_hsa051620.70880605
117Lysosome_Homo sapiens_hsa041420.69226780
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68814028
119Purine metabolism_Homo sapiens_hsa002300.67961537
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.64866487
121Shigellosis_Homo sapiens_hsa051310.64013032
122Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63735905
123NF-kappa B signaling pathway_Homo sapiens_hsa040640.63329687
124Propanoate metabolism_Homo sapiens_hsa006400.63221804
125Complement and coagulation cascades_Homo sapiens_hsa046100.62399306
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60582407
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60086091
128ECM-receptor interaction_Homo sapiens_hsa045120.59670850
129Histidine metabolism_Homo sapiens_hsa003400.58027764
130Thyroid cancer_Homo sapiens_hsa052160.57805242
131Staphylococcus aureus infection_Homo sapiens_hsa051500.57791925
132Pathways in cancer_Homo sapiens_hsa052000.57334212
133Jak-STAT signaling pathway_Homo sapiens_hsa046300.57172180
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56230893
135Fructose and mannose metabolism_Homo sapiens_hsa000510.55890902
136Viral carcinogenesis_Homo sapiens_hsa052030.55641180
137AMPK signaling pathway_Homo sapiens_hsa041520.55421332
138PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53882066
139Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53194623
140Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52784812
141Epstein-Barr virus infection_Homo sapiens_hsa051690.52541836
142mRNA surveillance pathway_Homo sapiens_hsa030150.52257703
143Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51466358
144Melanoma_Homo sapiens_hsa052180.51281180
145Type II diabetes mellitus_Homo sapiens_hsa049300.51174037
146Chemical carcinogenesis_Homo sapiens_hsa052040.50544814
147Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50385414
148Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49947710
149Intestinal immune network for IgA production_Homo sapiens_hsa046720.49612119
150NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49326254
151Platelet activation_Homo sapiens_hsa046110.48120919
152Notch signaling pathway_Homo sapiens_hsa043300.47934454
153Osteoclast differentiation_Homo sapiens_hsa043800.47256434
154Chronic myeloid leukemia_Homo sapiens_hsa052200.45818264
155Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45161903
156PPAR signaling pathway_Homo sapiens_hsa033200.45059054
157Fatty acid metabolism_Homo sapiens_hsa012120.44865385
158HTLV-I infection_Homo sapiens_hsa051660.42551759
159Central carbon metabolism in cancer_Homo sapiens_hsa052300.41400912
160Influenza A_Homo sapiens_hsa051640.41023212

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »