XPNPEP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the 'pita bread fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound and soluble form of this enzyme have been identified as products of two separate genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)8.89314962
2aminoglycoside antibiotic metabolic process (GO:0030647)7.82278811
3NADH metabolic process (GO:0006734)7.43422119
4regulation of guanylate cyclase activity (GO:0031282)7.16807098
5lipoprotein transport (GO:0042953)7.14036056
6fat-soluble vitamin biosynthetic process (GO:0042362)6.94522395
7somite rostral/caudal axis specification (GO:0032525)6.68375200
8negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)6.60887334
9regulation of bile acid biosynthetic process (GO:0070857)6.48677502
10regulation of mammary gland epithelial cell proliferation (GO:0033599)6.48139816
11maintenance of protein location in nucleus (GO:0051457)6.41021207
12negative regulation of epidermis development (GO:0045683)6.37136873
13intestinal absorption (GO:0050892)6.36170387
14regulation of nuclear cell cycle DNA replication (GO:0033262)6.30574120
15fructose metabolic process (GO:0006000)6.07371546
16negative regulation of cell cycle G2/M phase transition (GO:1902750)5.95145552
17regulation of MHC class I biosynthetic process (GO:0045343)5.66732061
18regulation of response to osmotic stress (GO:0047484)5.63242245
19negative regulation of telomerase activity (GO:0051974)5.58197843
20drug metabolic process (GO:0017144)5.55044599
21positive regulation of guanylate cyclase activity (GO:0031284)5.54162427
22regulation of triglyceride catabolic process (GO:0010896)5.47127812
23regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.42112040
24endocrine process (GO:0050886)5.42112040
25regulation of systemic arterial blood pressure by hormone (GO:0001990)5.42112040
26cytidine metabolic process (GO:0046087)5.31012681
27cytidine catabolic process (GO:0006216)5.31012681
28cytidine deamination (GO:0009972)5.31012681
29interferon-gamma production (GO:0032609)5.29661754
30negative regulation of epidermal cell differentiation (GO:0045605)5.27614027
31very-low-density lipoprotein particle assembly (GO:0034379)5.14494339
32muscle organ morphogenesis (GO:0048644)5.11993893
33regulation of telomere maintenance via telomerase (GO:0032210)5.09008515
34urea cycle (GO:0000050)5.03380634
35vitamin A metabolic process (GO:0006776)5.01480444
36virion attachment to host cell (GO:0019062)5.00609835
37adhesion of symbiont to host cell (GO:0044650)5.00609835
38regulation of apoptotic process involved in morphogenesis (GO:1902337)4.96773754
39notochord development (GO:0030903)4.95574252
40urea metabolic process (GO:0019627)4.95231534
41histone H4-K12 acetylation (GO:0043983)4.88670555
42regulation of systemic arterial blood pressure (GO:0003073)4.86978937
43positive regulation of DNA-dependent DNA replication (GO:2000105)4.86004321
44rRNA methylation (GO:0031167)4.84667047
45hormone catabolic process (GO:0042447)4.83190245
46diacylglycerol metabolic process (GO:0046339)4.82884664
47cellular glucuronidation (GO:0052695)4.82839554
48phenol-containing compound catabolic process (GO:0019336)4.80317009
49negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.79211418
50glucuronate metabolic process (GO:0019585)4.74634093
51uronic acid metabolic process (GO:0006063)4.74634093
52branching involved in mammary gland duct morphogenesis (GO:0060444)4.73624503
53histone H4-K5 acetylation (GO:0043981)4.70485480
54histone H4-K8 acetylation (GO:0043982)4.70485480
55rRNA transcription (GO:0009303)4.68040331
56regulation of cilium movement (GO:0003352)4.65174715
57plasma lipoprotein particle assembly (GO:0034377)4.62505608
58quinone metabolic process (GO:1901661)4.61395175
59nucleoside transmembrane transport (GO:1901642)4.59676164
60bile acid and bile salt transport (GO:0015721)4.58302138
61transepithelial transport (GO:0070633)4.55176456
62nitrogen cycle metabolic process (GO:0071941)4.55034189
63peptide catabolic process (GO:0043171)4.51295646
64peptide hormone processing (GO:0016486)4.50357709
65negative regulation of telomere maintenance (GO:0032205)4.48509157
66regulation of cellular extravasation (GO:0002691)4.45337989
67response to dietary excess (GO:0002021)4.36688252
68drug catabolic process (GO:0042737)4.35443064
69regulation of cGMP biosynthetic process (GO:0030826)4.34305603
70adhesion of symbiont to host (GO:0044406)4.33463816
71intestinal epithelial cell development (GO:0060576)4.33052822
72protein localization to kinetochore (GO:0034501)4.29115074
73receptor guanylyl cyclase signaling pathway (GO:0007168)4.28658050
74rRNA modification (GO:0000154)4.28636302
75protein-lipid complex assembly (GO:0065005)4.21141072
76alkaloid metabolic process (GO:0009820)4.20083962
77renal system process involved in regulation of blood volume (GO:0001977)4.20023351
78mitochondrion distribution (GO:0048311)4.16563268
79homocysteine metabolic process (GO:0050667)4.06842380
80primitive streak formation (GO:0090009)4.06705176
81digestion (GO:0007586)4.04840859
82glycolipid catabolic process (GO:0019377)4.04532917
83cellular response to nitric oxide (GO:0071732)4.03167333
84nucleoside transport (GO:0015858)4.00177035
85phospholipid efflux (GO:0033700)3.99531868
86glycosphingolipid catabolic process (GO:0046479)3.99304010
87omega-hydroxylase P450 pathway (GO:0097267)3.96978270
88exogenous drug catabolic process (GO:0042738)3.95823174
89flavonoid metabolic process (GO:0009812)3.94655906
90regulation of cholesterol esterification (GO:0010872)3.94478833
91regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.92224271
92thyroid hormone generation (GO:0006590)3.90538753
93lipoprotein metabolic process (GO:0042157)3.90237001
94GDP-mannose metabolic process (GO:0019673)3.87202198
95drinking behavior (GO:0042756)3.85256577
96vitamin transport (GO:0051180)3.85211334
97positive regulation of lipoprotein lipase activity (GO:0051006)3.83457840
98positive regulation of triglyceride lipase activity (GO:0061365)3.83457840
99vitamin transmembrane transport (GO:0035461)3.83091712
100mitotic sister chromatid segregation (GO:0000070)3.81350065
101pyrimidine ribonucleoside catabolic process (GO:0046133)3.78478415
102regulation of vitamin metabolic process (GO:0030656)3.71722076
103bile acid metabolic process (GO:0008206)3.69382248
104cell fate commitment involved in formation of primary germ layer (GO:0060795)3.66214088
105fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.64423751
106glutamine family amino acid biosynthetic process (GO:0009084)3.63270548
107regulation of cGMP metabolic process (GO:0030823)3.60473899
108cardiovascular system development (GO:0072358)3.60354683
109antibacterial humoral response (GO:0019731)3.55927651
110tachykinin receptor signaling pathway (GO:0007217)3.55322614
111thyroid hormone metabolic process (GO:0042403)3.55072100
112coenzyme catabolic process (GO:0009109)3.53833356
113vitamin biosynthetic process (GO:0009110)3.51903665
114maintenance of gastrointestinal epithelium (GO:0030277)3.49899060
115intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.49801310
116response to nitric oxide (GO:0071731)3.47282014
117signal transduction involved in regulation of gene expression (GO:0023019)3.47111011
118arginine metabolic process (GO:0006525)3.46858013
119antimicrobial humoral response (GO:0019730)3.46647558
120positive regulation of lipid catabolic process (GO:0050996)3.42732724
121regulation of telomere maintenance (GO:0032204)3.42552787
122cellular response to reactive nitrogen species (GO:1902170)3.41668828
123negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.37977107
124DNA replication checkpoint (GO:0000076)3.35744584
125drug transport (GO:0015893)3.33911907
126positive regulation of odontogenesis (GO:0042482)3.33249364
127midgut development (GO:0007494)3.33002186
128bone trabecula formation (GO:0060346)3.32275112
129regulation of translation in response to stress (GO:0043555)3.31537587
130regulation of telomerase activity (GO:0051972)3.29480574
131triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.28351416
132receptor recycling (GO:0001881)3.27711540
133phenylpropanoid metabolic process (GO:0009698)3.27587114
134sulfate transport (GO:0008272)3.24868517
135high-density lipoprotein particle remodeling (GO:0034375)3.24532096
136vitamin D metabolic process (GO:0042359)3.23480722
137heterochromatin organization (GO:0070828)3.23238898
138drug transmembrane transport (GO:0006855)3.22266724
139negative regulation of interleukin-2 production (GO:0032703)3.22044346
140L-ascorbic acid metabolic process (GO:0019852)3.21143595
141positive regulation of pseudopodium assembly (GO:0031274)3.21084990
142positive regulation of defense response to virus by host (GO:0002230)3.20878829
143ceramide catabolic process (GO:0046514)3.20741439
144positive regulation of glycoprotein biosynthetic process (GO:0010560)3.19570960
145positive regulation of cGMP biosynthetic process (GO:0030828)3.19217109
146renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.18586955
147histone H4-K16 acetylation (GO:0043984)3.17973388
148cGMP biosynthetic process (GO:0006182)3.16918287
149sulfur compound transport (GO:0072348)3.16520019
150DNA damage response, detection of DNA damage (GO:0042769)3.16475678
151plasma lipoprotein particle remodeling (GO:0034369)3.16139788
152protein-lipid complex remodeling (GO:0034368)3.16139788
153macromolecular complex remodeling (GO:0034367)3.16139788
154icosanoid secretion (GO:0032309)3.14428255
155arachidonic acid secretion (GO:0050482)3.14428255
156plasma lipoprotein particle organization (GO:0071827)3.14191473
157cholesterol homeostasis (GO:0042632)3.13807521
158urate metabolic process (GO:0046415)3.13616003
159proline metabolic process (GO:0006560)3.13403370
160maintenance of protein localization in organelle (GO:0072595)3.13312996
161glycerol metabolic process (GO:0006071)3.11473978
162phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.11353592
163cobalamin metabolic process (GO:0009235)3.11193756
164negative regulation of keratinocyte proliferation (GO:0010839)3.10973049
165glycosylceramide metabolic process (GO:0006677)3.10643342
166phagocytosis, recognition (GO:0006910)3.08797427
167regulation of cholesterol homeostasis (GO:2000188)3.08332281
168sterol homeostasis (GO:0055092)3.08191956
169digestive system process (GO:0022600)3.05588900
170protein localization to chromosome, centromeric region (GO:0071459)3.04243047
171leukotriene metabolic process (GO:0006691)3.04048319
172ethanol oxidation (GO:0006069)3.03722258
173branching involved in labyrinthine layer morphogenesis (GO:0060670)3.02563080
174retinoic acid receptor signaling pathway (GO:0048384)3.01585674
175positive regulation of digestive system process (GO:0060456)3.01097553
176pyrimidine-containing compound transmembrane transport (GO:0072531)2.97399457
177anterior/posterior axis specification (GO:0009948)2.94785897
178sister chromatid segregation (GO:0000819)2.94405204
179protein polyglutamylation (GO:0018095)2.87605552
180chromatin assembly (GO:0031497)2.85836113
181regulation of odontogenesis (GO:0042481)2.84473335
182epoxygenase P450 pathway (GO:0019373)2.83760524
183positive regulation of tissue remodeling (GO:0034105)2.83292879
184negative regulation of systemic arterial blood pressure (GO:0003085)2.83134018
185cyclooxygenase pathway (GO:0019371)2.82690018
186embryonic axis specification (GO:0000578)2.82383428
187regulation of G0 to G1 transition (GO:0070316)2.80253237
188cellular modified amino acid catabolic process (GO:0042219)2.75376609
189fat-soluble vitamin metabolic process (GO:0006775)2.73708963
190primary alcohol catabolic process (GO:0034310)2.73061851
191cofactor transport (GO:0051181)2.72730052
192daunorubicin metabolic process (GO:0044597)11.8345639
193polyketide metabolic process (GO:0030638)11.8345639
194doxorubicin metabolic process (GO:0044598)11.8345639
195angiotensin maturation (GO:0002003)11.3420987

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.76523647
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse7.14934679
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse7.14934679
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse7.14934679
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.00687102
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.36965947
7TP63_19390658_ChIP-ChIP_HaCaT_Human4.21989844
8NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.29762945
9HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.28691920
10RXR_22158963_ChIP-Seq_LIVER_Mouse3.25163833
11SOX2_18358816_ChIP-ChIP_MESCs_Mouse3.04792877
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.94485108
13CDX2_20551321_ChIP-Seq_CACO-2_Human2.88725860
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.86404038
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.85890074
16EGR1_23403033_ChIP-Seq_LIVER_Mouse2.80134394
17IRF1_19129219_ChIP-ChIP_H3396_Human2.79872167
18TCF3_18692474_ChIP-Seq_MESCs_Mouse2.79589291
19SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.76344890
20SOX2_27498859_Chip-Seq_STOMACH_Mouse2.69580317
21GATA1_22025678_ChIP-Seq_K562_Human2.63515255
22NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.53266817
23IRF8_22096565_ChIP-ChIP_GC-B_Human2.41412002
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.41379604
25TCF3_18692474_ChIP-Seq_MEFs_Mouse2.36129131
26TRIM28_21343339_ChIP-Seq_HEK293_Human2.29350509
27CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.26909772
28POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.26450154
29* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.25735549
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10526833
31E2F7_22180533_ChIP-Seq_HELA_Human2.09792944
32SOX2_20726797_ChIP-Seq_SW620_Human2.05140747
33CDX2_19796622_ChIP-Seq_MESCs_Mouse2.05067490
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.98491269
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.96326239
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.92101924
37BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.86841626
38NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.83398573
39POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.81446099
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.79134807
41TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.76959447
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.73078372
43LXR_22292898_ChIP-Seq_THP-1_Human1.71831411
44PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.69696867
45NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.63308011
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.62017390
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.58487707
48ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.58461723
49CLOCK_20551151_ChIP-Seq_293T_Human1.57534462
50FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.57408550
51RNF2_27304074_Chip-Seq_NSC_Mouse1.54186581
52POU5F1_16518401_ChIP-PET_MESCs_Mouse1.52741847
53AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.52138674
54NANOG_18692474_ChIP-Seq_MESCs_Mouse1.51078265
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50400698
56* HNF4A_19822575_ChIP-Seq_HepG2_Human1.45876536
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.45156399
58PPAR_26484153_Chip-Seq_NCI-H1993_Human1.44043178
59PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.42779858
60E2F4_17652178_ChIP-ChIP_JURKAT_Human1.40500457
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40292753
62HIF1A_21447827_ChIP-Seq_MCF-7_Human1.38312800
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.35238858
64NANOG_18692474_ChIP-Seq_MEFs_Mouse1.35189576
65TCF4_18268006_ChIP-ChIP_LS174T_Human1.34686410
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34533271
67E2F1_17053090_ChIP-ChIP_MCF-7_Human1.31418480
68POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.30007123
69NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.28723307
70TP63_17297297_ChIP-ChIP_HaCaT_Human1.27456871
71PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25128615
72KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23724661
73IRF8_21731497_ChIP-ChIP_J774_Mouse1.21200708
74FOXA2_19822575_ChIP-Seq_HepG2_Human1.17960248
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16244025
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14939036
77RACK7_27058665_Chip-Seq_MCF-7_Human1.14137116
78SA1_27219007_Chip-Seq_Bcells_Human1.13300749
79ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13152295
80GATA2_19941826_ChIP-Seq_K562_Human1.13146242
81FOXA1_25552417_ChIP-Seq_VCAP_Human1.12863942
82NANOG_16153702_ChIP-ChIP_HESCs_Human1.10388464
83SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09921914
84SOX2_18692474_ChIP-Seq_MESCs_Mouse1.09564457
85BCL6_27268052_Chip-Seq_Bcells_Human1.09434107
86* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09388868
87CDX2_22108803_ChIP-Seq_LS180_Human1.08742029
88TET1_21451524_ChIP-Seq_MESCs_Mouse1.08178418
89IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07728310
90CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07642654
91GATA1_19941826_ChIP-Seq_K562_Human1.06313470
92ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04556050
93TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.03194123
94STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.03091989
95* BCOR_27268052_Chip-Seq_Bcells_Human1.03008404
96FLI1_27457419_Chip-Seq_LIVER_Mouse1.01709971
97VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01701117
98KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01423157
99CTCF_27219007_Chip-Seq_Bcells_Human1.00444736
100RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99889173
101* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.99596848
102FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99168433
103SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98973159
104STAT3_18555785_ChIP-Seq_MESCs_Mouse0.98388063
105PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98179402
106EGR1_19032775_ChIP-ChIP_M12_Human0.97210542
107RXR_22108803_ChIP-Seq_LS180_Human0.97128197
108* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96427518
109GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96337694
110VDR_22108803_ChIP-Seq_LS180_Human0.95824775
111* NANOG_16518401_ChIP-PET_MESCs_Mouse0.95621091
112VDR_24787735_ChIP-Seq_THP-1_Human0.95464786
113CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95391270
114DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94658282
115MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.93744370
116P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93553806
117FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.93210956
118SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91932098
119OCT4_18692474_ChIP-Seq_MEFs_Mouse0.91165915
120POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.90510523
121NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90410355
122PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90326504
123ESR2_21235772_ChIP-Seq_MCF-7_Human0.89645525
124SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88716029
125SOX2_18692474_ChIP-Seq_MEFs_Mouse0.88527264
126TP53_22127205_ChIP-Seq_IMR90_Human0.88216359
127NANOG_20526341_ChIP-Seq_ESCs_Human0.88150534
128SMAD3_21741376_ChIP-Seq_HESCs_Human0.86523160
129SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.86473337
130* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86352719
131GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85520248
132RAD21_21589869_ChIP-Seq_MESCs_Mouse0.85051225
133PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84521430
134STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.84035114
135* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83356818
136ESR1_21235772_ChIP-Seq_MCF-7_Human0.83202501
137VDR_24763502_ChIP-Seq_THP-1_Human0.82804736
138EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.82636908
139CEBPB_22108803_ChIP-Seq_LS180_Human0.82606319
140MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.81931573
141TBX3_20139965_ChIP-Seq_ESCs_Mouse0.80146312
142CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.79843781
143SCL_19346495_ChIP-Seq_HPC-7_Human0.79568207
144TBX3_20139965_ChIP-Seq_MESCs_Mouse0.79047956
145AR_21909140_ChIP-Seq_LNCAP_Human0.78964424
146CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78605461
147ZFP281_27345836_Chip-Seq_ESCs_Mouse0.78121789
148GATA1_22383799_ChIP-Seq_G1ME_Mouse0.77647778
149RING1B_27294783_Chip-Seq_NPCs_Mouse0.77612283
150ZNF263_19887448_ChIP-Seq_K562_Human0.76451986
151CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.76371079
152KAP1_27257070_Chip-Seq_ESCs_Mouse0.75968070
153EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.75441348
154TP53_20018659_ChIP-ChIP_R1E_Mouse0.75390312
155IGF1R_20145208_ChIP-Seq_DFB_Human0.75229841
156SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.75091980
157KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74949907
158Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.74726930
159RUNX1_27514584_Chip-Seq_MCF-7_Human0.74287815
160SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.74129369
161SOX2_16153702_ChIP-ChIP_HESCs_Human0.73990120
162TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.73212439
163TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72947155
164ESET_19884257_ChIP-Seq_ESCs_Mouse0.72885707
165TP63_22573176_ChIP-Seq_HFKS_Human0.72867825
166BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.72459188
167GATA1_26923725_Chip-Seq_HPCs_Mouse0.71591532
168STAT6_21828071_ChIP-Seq_BEAS2B_Human0.65935528
169SRY_22984422_ChIP-ChIP_TESTIS_Rat0.65916300
170GATA6_25053715_ChIP-Seq_YYC3_Human0.65883181
171IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.65775005
172HOXB7_26014856_ChIP-Seq_BT474_Human0.65440810
173KLF5_25053715_ChIP-Seq_YYC3_Human0.65406918
174RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.64563196
175SPI1_26923725_Chip-Seq_HPCs_Mouse0.63276846
176ELK4_26923725_Chip-Seq_MESODERM_Mouse0.62359338
177SMAD1_18555785_Chip-Seq_ESCs_Mouse0.60466078
178RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.56750405
179GATA4_25053715_ChIP-Seq_YYC3_Human0.56453640
180WT1_19549856_ChIP-ChIP_CCG9911_Human0.56440197
181CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.56367447
182NCOR1_26117541_ChIP-Seq_K562_Human0.55713016
183ZFX_18555785_Chip-Seq_ESCs_Mouse0.54115794
184ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.54073324
185LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.53883426
186FOXO3_23340844_ChIP-Seq_DLD1_Human0.53170832

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004264_abnormal_extraembryonic_tissu5.14213634
2MP0006292_abnormal_olfactory_placode5.06636041
3MP0002254_reproductive_system_inflammat4.95548442
4MP0005085_abnormal_gallbladder_physiolo4.93976236
5MP0001666_abnormal_nutrient_absorption4.93012836
6MP0003011_delayed_dark_adaptation4.62980590
7MP0002139_abnormal_hepatobiliary_system4.28799520
8MP0005365_abnormal_bile_salt4.03095387
9MP0009840_abnormal_foam_cell3.70412654
10MP0005257_abnormal_intraocular_pressure3.68920766
11MP0005075_abnormal_melanosome_morpholog3.68860188
12MP0005499_abnormal_olfactory_system3.45932166
13MP0005394_taste/olfaction_phenotype3.45932166
14MP0003183_abnormal_peptide_metabolism3.34309744
15MP0009379_abnormal_foot_pigmentation3.33157069
16MP0004147_increased_porphyrin_level3.16841652
17MP0003890_abnormal_embryonic-extraembry3.16256595
18MP0002277_abnormal_respiratory_mucosa2.96179763
19MP0004858_abnormal_nervous_system2.71212805
20MP0003122_maternal_imprinting2.55199787
21MP0008057_abnormal_DNA_replication2.50212568
22MP0002332_abnormal_exercise_endurance2.46088510
23MP0000678_abnormal_parathyroid_gland2.45017370
24MP0010329_abnormal_lipoprotein_level2.33897113
25MP0003938_abnormal_ear_development2.33223091
26MP0010234_abnormal_vibrissa_follicle2.20077258
27MP0003868_abnormal_feces_composition2.18507393
28MP0005332_abnormal_amino_acid2.14084858
29MP0002653_abnormal_ependyma_morphology2.12801413
30MP0005409_darkened_coat_color2.04314051
31MP0006035_abnormal_mitochondrial_morpho1.96552465
32MP0009643_abnormal_urine_homeostasis1.94480670
33MP0003121_genomic_imprinting1.86031368
34MP0006082_CNS_inflammation1.80248868
35MP0004381_abnormal_hair_follicle1.80080289
36MP0002132_abnormal_respiratory_system1.79240931
37MP0003252_abnormal_bile_duct1.79064363
38MP0001664_abnormal_digestion1.76266847
39MP0003866_abnormal_defecation1.69587740
40MP0001764_abnormal_homeostasis1.65964169
41MP0004043_abnormal_pH_regulation1.62110266
42MP0000762_abnormal_tongue_morphology1.61836737
43MP0008789_abnormal_olfactory_epithelium1.61416762
44MP0005670_abnormal_white_adipose1.61171506
45MP0000490_abnormal_crypts_of1.60978929
46MP0000538_abnormal_urinary_bladder1.57388319
47MP0003315_abnormal_perineum_morphology1.54952838
48MP0000049_abnormal_middle_ear1.49830133
49MP0003806_abnormal_nucleotide_metabolis1.45292760
50MP0004957_abnormal_blastocyst_morpholog1.41096636
51MP0010030_abnormal_orbit_morphology1.38008026
52MP0001765_abnormal_ion_homeostasis1.37065282
53MP0001293_anophthalmia1.36115324
54MP0005636_abnormal_mineral_homeostasis1.34986719
55MP0002127_abnormal_cardiovascular_syste1.34217804
56MP0005166_decreased_susceptibility_to1.31737997
57MP0002932_abnormal_joint_morphology1.30925407
58MP0002118_abnormal_lipid_homeostasis1.29142408
59MP0002098_abnormal_vibrissa_morphology1.28300576
60MP0003787_abnormal_imprinting1.27158717
61MP0002136_abnormal_kidney_physiology1.25226028
62MP0003718_maternal_effect1.24852160
63MP0000383_abnormal_hair_follicle1.24840905
64MP0010352_gastrointestinal_tract_polyps1.24515820
65MP0002233_abnormal_nose_morphology1.22810793
66MP0005248_abnormal_Harderian_gland1.22261209
67MP0003879_abnormal_hair_cell1.22064249
68MP0004782_abnormal_surfactant_physiolog1.19808182
69MP0002138_abnormal_hepatobiliary_system1.16975272
70MP0003136_yellow_coat_color1.16444454
71MP0002396_abnormal_hematopoietic_system1.16052344
72MP0001672_abnormal_embryogenesis/_devel1.13037835
73MP0005380_embryogenesis_phenotype1.13037835
74MP0002822_catalepsy1.11490494
75MP0000609_abnormal_liver_physiology1.10645135
76MP0002092_abnormal_eye_morphology1.08408379
77MP0005377_hearing/vestibular/ear_phenot1.07466955
78MP0003878_abnormal_ear_physiology1.07466955
79MP0000566_synostosis1.07182803
80MP0000462_abnormal_digestive_system1.06961482
81MP0005360_urolithiasis1.05382079
82MP0005535_abnormal_body_temperature1.03231619
83MP0002249_abnormal_larynx_morphology1.01858198
84MP0004270_analgesia1.00541462
85MP0002971_abnormal_brown_adipose1.00232493
86MP0002088_abnormal_embryonic_growth/wei0.99532284
87MP0005448_abnormal_energy_balance0.99401664
88MP0001756_abnormal_urination0.99383810
89MP0005584_abnormal_enzyme/coenzyme_acti0.98947974
90MP0000432_abnormal_head_morphology0.98348695
91MP0003755_abnormal_palate_morphology0.98239338
92MP0005266_abnormal_metabolism0.97837432
93MP0003984_embryonic_growth_retardation0.97450131
94MP0002114_abnormal_axial_skeleton0.96648173
95MP0002876_abnormal_thyroid_physiology0.95284245
96MP0008875_abnormal_xenobiotic_pharmacok0.94850850
97MP0003941_abnormal_skin_development0.94699874
98MP0005451_abnormal_body_composition0.94683303
99MP0001501_abnormal_sleep_pattern0.94148884
100MP0002751_abnormal_autonomic_nervous0.92973584
101MP0003705_abnormal_hypodermis_morpholog0.92824800
102MP0001663_abnormal_digestive_system0.92678280
103MP0001849_ear_inflammation0.91973243
104MP0001873_stomach_inflammation0.87825994
105MP0008961_abnormal_basal_metabolism0.84330329
106MP0001845_abnormal_inflammatory_respons0.81397378
107MP0005319_abnormal_enzyme/_coenzyme0.81284673
108MP0003935_abnormal_craniofacial_develop0.80497363
109MP0000230_abnormal_systemic_arterial0.80393672
110MP0003119_abnormal_digestive_system0.79992781
111MP0009115_abnormal_fat_cell0.79755096
112MP0003191_abnormal_cellular_cholesterol0.79188617
113MP0005381_digestive/alimentary_phenotyp0.77672096
114MP0005310_abnormal_salivary_gland0.77375675
115MP0008469_abnormal_protein_level0.76037994
116MP0005391_vision/eye_phenotype0.75936409
117MP0001286_abnormal_eye_development0.75206199
118MP0009642_abnormal_blood_homeostasis0.75124536
119MP0008872_abnormal_physiological_respon0.74453062
120MP0000350_abnormal_cell_proliferation0.73649841
121MP0005508_abnormal_skeleton_morphology0.71185867
122MP0000372_irregular_coat_pigmentation0.69688943
123MP0000428_abnormal_craniofacial_morphol0.68200697
124MP0002116_abnormal_craniofacial_bone0.67717578
125MP0002086_abnormal_extraembryonic_tissu0.66966026
126MP0005666_abnormal_adipose_tissue0.65595358
127MP0003300_gastrointestinal_ulcer0.63265891
128MP0000249_abnormal_blood_vessel0.62578505
129MP0003950_abnormal_plasma_membrane0.62027695
130MP0004133_heterotaxia0.61642187
131MP0003283_abnormal_digestive_organ0.61304324
132MP0003937_abnormal_limbs/digits/tail_de0.60436459
133MP0010678_abnormal_skin_adnexa0.60421010
134MP0002085_abnormal_embryonic_tissue0.60340478
135MP0010155_abnormal_intestine_physiology0.60125312
136MP0009764_decreased_sensitivity_to0.60029000
137MP0009697_abnormal_copulation0.59423842
138MP0001324_abnormal_eye_pigmentation0.59231079
139MP0000477_abnormal_intestine_morphology0.58862156
140MP0000313_abnormal_cell_death0.58665697
141MP0000604_amyloidosis0.58549960
142MP0003638_abnormal_response/metabolism_0.58473451
143MP0000377_abnormal_hair_follicle0.57993664
144MP0005334_abnormal_fat_pad0.56491845
145MP0004019_abnormal_vitamin_homeostasis0.56246855
146MP0002166_altered_tumor_susceptibility0.56241263
147MP0001188_hyperpigmentation0.55272368
148MP0002970_abnormal_white_adipose0.54887581
149MP0005253_abnormal_eye_physiology0.53672843
150MP0003786_premature_aging0.53554455
151MP0005058_abnormal_lysosome_morphology0.53449824
152MP0000026_abnormal_inner_ear0.52272232
153MP0003077_abnormal_cell_cycle0.52223074
154MP0000537_abnormal_urethra_morphology0.52086981
155MP0001270_distended_abdomen0.52036184
156MP0003724_increased_susceptibility_to0.51989507
157MP0002078_abnormal_glucose_homeostasis0.51851494
158MP0005025_abnormal_response_to0.51428664
159MP0006138_congestive_heart_failure0.51006421
160MP0001485_abnormal_pinna_reflex0.50088421
161MP0005671_abnormal_response_to0.50059601
162MP0003137_abnormal_impulse_conducting0.49856792
163MP0003436_decreased_susceptibility_to0.49588061
164MP0001835_abnormal_antigen_presentation0.49489183
165MP0002796_impaired_skin_barrier0.49214141
166MP0000613_abnormal_salivary_gland0.48930653
167MP0003123_paternal_imprinting0.48903500
168MP0000465_gastrointestinal_hemorrhage0.48000829
169MP0009785_altered_susceptibility_to0.47512743
170MP0003953_abnormal_hormone_level0.47269332
171MP0005501_abnormal_skin_physiology0.47009965
172MP0003195_calcinosis0.46628626
173MP0008260_abnormal_autophagy0.45976595
174MP0002896_abnormal_bone_mineralization0.45648417
175MP0005376_homeostasis/metabolism_phenot0.43816596
176MP0005395_other_phenotype0.42631138
177MP0009333_abnormal_splenocyte_physiolog0.42551857
178MP0004947_skin_inflammation0.41103704
179MP0001881_abnormal_mammary_gland0.38953099
180MP0003303_peritoneal_inflammation0.38462523

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)7.41996516
2Hydroxyprolinuria (HP:0003080)7.40260274
3Abnormality of proline metabolism (HP:0010907)7.40260274
4Hypobetalipoproteinemia (HP:0003563)6.22262643
5Hypochromic microcytic anemia (HP:0004840)5.93797849
6Chromosomal breakage induced by crosslinking agents (HP:0003221)5.34636467
7Abnormality of the vitamin B12 metabolism (HP:0004341)5.24557602
8Hepatoblastoma (HP:0002884)5.10343706
9Chronic diarrhea (HP:0002028)5.03370489
10Widely patent fontanelles and sutures (HP:0004492)4.93511827
11Abnormality of vitamin B metabolism (HP:0004340)4.89965568
12Confusion (HP:0001289)4.68447349
13Fat malabsorption (HP:0002630)4.66784025
14Chromsome breakage (HP:0040012)4.53095577
15Ileus (HP:0002595)4.52045401
16Rib fusion (HP:0000902)4.51991502
17Acanthocytosis (HP:0001927)4.47837837
18Hypoplasia of the fovea (HP:0007750)4.34104113
19Aplasia/Hypoplasia of the fovea (HP:0008060)4.34104113
20Hyperglycinuria (HP:0003108)4.22628263
21Systemic lupus erythematosus (HP:0002725)4.21009576
22Abnormality of vitamin metabolism (HP:0100508)4.06262844
23Nephroblastoma (Wilms tumor) (HP:0002667)3.98556326
24Glycosuria (HP:0003076)3.80644844
25Abnormality of urine glucose concentration (HP:0011016)3.80644844
26Nausea (HP:0002018)3.79790358
27Abnormality of monocarboxylic acid metabolism (HP:0010996)3.75241412
28Pigmentary retinal degeneration (HP:0001146)3.68579260
29Embryonal renal neoplasm (HP:0011794)3.67523341
30Proximal tubulopathy (HP:0000114)3.66109065
31Wide cranial sutures (HP:0010537)3.65323770
32Abnormality of glycine metabolism (HP:0010895)3.62003164
33Abnormality of serine family amino acid metabolism (HP:0010894)3.62003164
34Xanthomatosis (HP:0000991)3.60743083
35Thin bony cortex (HP:0002753)3.57689013
36Multiple enchondromatosis (HP:0005701)3.54255742
37Anomalous pulmonary venous return (HP:0010772)3.52332755
38Potter facies (HP:0002009)3.47423670
39Facial shape deformation (HP:0011334)3.47423670
40Nephrolithiasis (HP:0000787)3.40325168
41Reduced antithrombin III activity (HP:0001976)3.38432376
42Partial duplication of thumb phalanx (HP:0009944)3.36896506
43Testicular atrophy (HP:0000029)3.35128114
44Abnormality of the fovea (HP:0000493)3.28764106
45Hyperuricemia (HP:0002149)3.23545385
46Increased purine levels (HP:0004368)3.23545385
47Metabolic alkalosis (HP:0200114)3.23190328
48Rectovaginal fistula (HP:0000143)3.15603202
49Rectal fistula (HP:0100590)3.15603202
50Bifid tongue (HP:0010297)3.13540088
51Alkalosis (HP:0001948)3.11333290
52Hypolipoproteinemia (HP:0010981)3.11062068
53Hypophosphatemia (HP:0002148)3.09918767
54Abnormality of the lower motor neuron (HP:0002366)3.07228653
55Megaloblastic anemia (HP:0001889)3.07078803
56Steatorrhea (HP:0002570)3.06609715
57Abnormality of small intestinal villus morphology (HP:0011472)3.06534193
58Villous atrophy (HP:0011473)3.06534193
59Nasolacrimal duct obstruction (HP:0000579)3.06395541
60Abnormality of the pulmonary veins (HP:0011718)3.05327447
61Hyperactive renin-angiotensin system (HP:0000841)3.01804436
62Abnormal lung lobation (HP:0002101)3.00481479
63Meckel diverticulum (HP:0002245)2.99913670
64Abdominal distention (HP:0003270)2.98329600
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.94819942
66Intestinal fistula (HP:0100819)2.93669125
67Abnormality of purine metabolism (HP:0004352)2.93457092
68Cheilitis (HP:0100825)2.88556780
69Abnormality of aspartate family amino acid metabolism (HP:0010899)2.86501518
70Periauricular skin pits (HP:0100277)2.85568944
71Preauricular pit (HP:0004467)2.85568944
72Malnutrition (HP:0004395)2.85159206
73Abnormal urine phosphate concentration (HP:0012599)2.84991808
74Partial duplication of the phalanx of hand (HP:0009999)2.84056554
75Abnormality of the ileum (HP:0001549)2.82830297
76Congenital sensorineural hearing impairment (HP:0008527)2.82149174
77Neoplasm of striated muscle (HP:0009728)2.81213798
78Hyperammonemia (HP:0001987)2.81062175
79Ependymoma (HP:0002888)2.80507671
80Rhabdomyosarcoma (HP:0002859)2.78532310
81Decreased circulating renin level (HP:0003351)2.75889065
82Fused cervical vertebrae (HP:0002949)2.75320899
83Abnormality of the salivary glands (HP:0010286)2.73018424
84Abnormality of nucleobase metabolism (HP:0010932)2.72376524
85Microvesicular hepatic steatosis (HP:0001414)2.71780481
86Hyperphosphaturia (HP:0003109)2.71437839
87Vaginal fistula (HP:0004320)2.70278331
88Posterior subcapsular cataract (HP:0007787)2.66193981
89Aplasia/Hypoplasia of the macula (HP:0008059)2.63316694
90Upper limb muscle weakness (HP:0003484)2.62790585
91Hyperventilation (HP:0002883)2.61957009
923-Methylglutaconic aciduria (HP:0003535)2.59990480
93Abnormality of the phalanges of the hallux (HP:0010057)2.58389516
94Enlarged epiphyses (HP:0010580)2.57717194
95Hyperinsulinemic hypoglycemia (HP:0000825)2.57482168
96Combined immunodeficiency (HP:0005387)2.56152394
97Hypotension (HP:0002615)2.55967608
98Horizontal nystagmus (HP:0000666)2.55927988
99Delayed epiphyseal ossification (HP:0002663)2.55552979
100Pendular nystagmus (HP:0012043)2.54008651
101Gout (HP:0001997)2.51913397
102Shawl scrotum (HP:0000049)2.51311932
103Hypochromic anemia (HP:0001931)2.49312585
104Sensory axonal neuropathy (HP:0003390)2.49281557
105Hyperparathyroidism (HP:0000843)2.48881126
106Type I transferrin isoform profile (HP:0003642)2.47755232
107Hemorrhage of the eye (HP:0011885)2.45969064
108Abnormality of the lacrimal duct (HP:0011481)2.45721661
109Focal segmental glomerulosclerosis (HP:0000097)2.44836976
110Abnormality of renin-angiotensin system (HP:0000847)2.40620400
111Aplasia/hypoplasia of the humerus (HP:0006507)2.39468117
112Dyschromatopsia (HP:0007641)2.38986197
113Epidermoid cyst (HP:0200040)2.38980910
114Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.38321768
115Tongue fasciculations (HP:0001308)2.35826935
116Impulsivity (HP:0100710)2.34540104
117Short humerus (HP:0005792)2.33758342
118Duplication of thumb phalanx (HP:0009942)2.32841999
119Metabolic acidosis (HP:0001942)2.32746455
120Ragged-red muscle fibers (HP:0003200)2.31798848
121Abnormality of the preputium (HP:0100587)2.28864580
122Febrile seizures (HP:0002373)2.28669320
123Complement deficiency (HP:0004431)2.28663228
124Small intestinal stenosis (HP:0012848)2.27783519
125Duodenal stenosis (HP:0100867)2.27783519
126Abnormality of pyrimidine metabolism (HP:0004353)2.26382559
127Abnormality of the costochondral junction (HP:0000919)2.26371905
128Abnormality of magnesium homeostasis (HP:0004921)2.24938466
129Eczematoid dermatitis (HP:0000976)2.24581006
130Abnormality of the distal phalanx of the thumb (HP:0009617)2.20755927
131Abnormality of sulfur amino acid metabolism (HP:0004339)2.20622431
132Abnormality of complement system (HP:0005339)2.20157818
133Trismus (HP:0000211)2.19723065
134Aplasia/Hypoplasia affecting the retina (HP:0008061)2.17807663
135Supernumerary spleens (HP:0009799)2.16128623
136Protuberant abdomen (HP:0001538)2.12983964
137Abnormal glucose tolerance (HP:0001952)2.12677991
138Glomerulonephritis (HP:0000099)2.11324493
139Neoplasm of the tracheobronchial system (HP:0100552)2.10726137
140Large earlobe (HP:0009748)2.08415381
141Skin pits (HP:0100276)2.08056506
142Renal tubular acidosis (HP:0001947)2.07087156
143Facial cleft (HP:0002006)2.05501383
144Bile duct proliferation (HP:0001408)2.05258738
145Abnormal biliary tract physiology (HP:0012439)2.05258738
146Abnormality of the nasolacrimal system (HP:0000614)2.05162782
147Irritability (HP:0000737)2.04724771
148Poikilocytosis (HP:0004447)2.04042233
149Embryonal neoplasm (HP:0002898)2.03859226
150Abnormality of chromosome segregation (HP:0002916)2.03295155
151Subcapsular cataract (HP:0000523)2.02178880
152Osteomalacia (HP:0002749)2.01390735
153Pancreatitis (HP:0001733)2.00778453
154Abnormality of the pubic bones (HP:0003172)2.00041817
155Abnormality of glutamine family amino acid metabolism (HP:0010902)10.6692446
156Abnormal enzyme/coenzyme activity (HP:0012379)1.98455515
157Abnormality of alkaline phosphatase activity (HP:0004379)1.97940275
158Muscle fibrillation (HP:0010546)1.96881770
159Gingivitis (HP:0000230)1.96438159
160Supernumerary nipples (HP:0002558)1.95562223
161Amyotrophic lateral sclerosis (HP:0007354)1.94887001
162Cerebral palsy (HP:0100021)1.92465654
163Hyperphosphatemia (HP:0002905)1.90478097
164Abnormality of the astrocytes (HP:0100707)1.90161587
165Astrocytoma (HP:0009592)1.90161587
166Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89958953
167Abnormal cartilage morphology (HP:0002763)1.89467729
168Generalized hypotonia (HP:0001290)1.87860398
169Preauricular skin tag (HP:0000384)1.87611480
170Progressive external ophthalmoplegia (HP:0000590)1.86673911
171Microretrognathia (HP:0000308)1.86620321
172Increased connective tissue (HP:0009025)1.85556020
173Intrahepatic cholestasis (HP:0001406)1.85391704
174Dicarboxylic aciduria (HP:0003215)1.84768737
175Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84768737
176Conjugated hyperbilirubinemia (HP:0002908)1.83454343
177Renal tubular dysfunction (HP:0000124)1.83255735
178Gastrointestinal dysmotility (HP:0002579)1.83138204
179Prostate neoplasm (HP:0100787)1.82888895
180Abnormality of liposaccharide metabolism (HP:0010968)1.82336732
181Abnormality of glycosphingolipid metabolism (HP:0004343)1.82336732
182Abnormality of glycolipid metabolism (HP:0010969)1.82336732
183Glomerulosclerosis (HP:0000096)1.82208225
184Abnormality of the duodenum (HP:0002246)1.82111478
185Orchitis (HP:0100796)1.81538140
186Nephritis (HP:0000123)1.79926572
187Abnormality of the prostate (HP:0008775)1.79425715
188Generalized aminoaciduria (HP:0002909)1.79031271
189Multiple lipomas (HP:0001012)1.76743586
190Right ventricular cardiomyopathy (HP:0011663)1.75473729
191Elevated alkaline phosphatase (HP:0003155)1.72826524
192Rickets (HP:0002748)1.69101899
193Growth hormone excess (HP:0000845)1.66298810
194Lethargy (HP:0001254)1.65770873
195White forelock (HP:0002211)1.64483852
196Hypokalemia (HP:0002900)1.64372961
197Metaphyseal irregularity (HP:0003025)1.62961245

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B8.25903171
2CDK127.69987536
3GRK54.79829628
4GRK64.06951083
5GRK13.88741331
6ADRBK23.75927190
7ERN13.75829502
8RIPK13.62922203
9GRK72.84930185
10CSF1R2.80892817
11AKT32.59156110
12MAPK72.47139450
13TTK2.46252157
14TGFBR22.41314791
15MATK2.40188664
16MST1R2.23293637
17OXSR12.10162956
18STK392.01722396
19FGFR42.00588298
20WNK11.98996036
21TESK21.92560499
22PRKG21.90808441
23TYRO31.86370455
24STK101.78631940
25EPHA21.78522582
26TYK21.68807406
27PTK61.65790735
28MOS1.49053428
29EPHA31.47404407
30EPHB21.46821796
31EIF2AK21.46222852
32DDR21.44144912
33PDK21.42903905
34MAP3K121.40048726
35CDK71.38656265
36MAP4K11.36441748
37CAMK41.35292253
38MST41.33310673
39EPHA41.28966313
40EPHB11.24482132
41RIPK41.20835458
42MAP3K11.14543109
43CHEK21.12465275
44MYLK1.10599309
45PIK3CA1.08788792
46ADRBK11.06597324
47MAP2K61.04007910
48CASK1.02883332
49MARK21.02854127
50NTRK10.96481060
51STK240.94571607
52PRPF4B0.93994101
53FGFR30.92914997
54NLK0.92554840
55PDPK10.91092122
56MAP3K110.91024961
57HIPK20.87505909
58CDC42BPA0.86102034
59IRAK30.85976851
60DYRK1B0.85796709
61TESK10.84969491
62MAP2K40.84863200
63CSK0.83654498
64PAK40.81218166
65MAPK110.76631948
66PLK10.76295038
67IKBKB0.75855151
68PIM10.75113655
69ZAK0.74944916
70TAOK10.74605427
71YES10.73203311
72MAP3K30.71193029
73MET0.70865040
74NME10.67746831
75PDK10.65321783
76LMTK20.64522541
77TBK10.61197688
78KSR20.61048110
79AKT20.60135552
80PRKCZ0.60012280
81PRKCA0.59568241
82PDGFRA0.59198953
83PRKCI0.58418577
84TAOK20.56059610
85PIK3CG0.55017234
86CDK80.54110934
87MAPK120.53742037
88MAP2K20.50667798
89TXK0.49900817
90PRKCD0.49817314
91IGF1R0.49114826
92FER0.48825685
93ITK0.48647854
94JAK10.48214665
95SRC0.48058155
96RET0.45819740
97IRAK10.45142054
98ABL20.43423974
99FYN0.43376596
100CHEK10.42924648
101CHUK0.42818566
102MAP3K70.42073170
103SRPK10.41505102
104JAK20.41503058
105CDK60.41132877
106BLK0.40244403
107ERBB20.39660280
108MAP3K140.38645474
109CAMK2D0.38246251
110TRIB30.37474193
111IRAK40.36816516
112PTK20.35810784
113BTK0.35651155
114TNK20.34133067
115CAMK2G0.33223237
116SYK0.32119028
117ZAP700.31724633
118SIK30.30341806
119IKBKE0.30055966
120NUAK10.28976233
121TEC0.28729893
122CAMK2B0.28372248
123CDK190.27567501
124MELK0.26887681
125DAPK20.26544979
126KIT0.25205088
127RPS6KA20.25161772
128MAP3K80.24294493
129INSR0.23818851
130STK38L0.23789102
131LYN0.23342913
132TNIK0.23068424
133DYRK1A0.22319491
134PRKD20.21764667
135LCK0.21337815
136BMX0.21059986
137AURKB0.20929513
138MKNK20.20781297
139PRKACA0.18589539
140ATM0.18585667
141CDK20.16868096
142MAPKAPK20.14708024
143MAPK40.14501307
144PRKACG0.14113940
145MAPK10.13646345
146GSK3B0.12635555
147MAPK140.12414710
148DYRK20.12144617
149FRK0.12116512
150BMPR20.11084554
151MAPK30.10600557
152PRKAA10.10511756
153AURKA0.10272671
154GSK3A0.10238316
155CSNK1E0.10201293
156CSNK1A10.09363697
157PRKACB0.09000682
158MAP3K100.08790564
159PRKAA20.08044435
160MAP3K20.07292913
161CDK10.06992716
162PAK10.06772707
163NEK60.05845988
164MAPK100.05845950

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006036.05041136
2Vitamin B6 metabolism_Homo sapiens_hsa007505.24546796
3Cyanoamino acid metabolism_Homo sapiens_hsa004605.03905382
4Fructose and mannose metabolism_Homo sapiens_hsa000513.83503565
5Arachidonic acid metabolism_Homo sapiens_hsa005903.35976779
6Galactose metabolism_Homo sapiens_hsa000523.00066318
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.59221904
8Linoleic acid metabolism_Homo sapiens_hsa005912.58076149
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.57812344
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.52596967
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.42078194
12Arginine biosynthesis_Homo sapiens_hsa002202.41428054
13Caffeine metabolism_Homo sapiens_hsa002322.39266165
14Renin-angiotensin system_Homo sapiens_hsa046142.06880120
15Drug metabolism - other enzymes_Homo sapiens_hsa009832.02934385
16Carbohydrate digestion and absorption_Homo sapiens_hsa049732.00005026
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.99175447
18Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.97069297
19Mineral absorption_Homo sapiens_hsa049781.88282183
20Fanconi anemia pathway_Homo sapiens_hsa034601.88169865
21Vitamin digestion and absorption_Homo sapiens_hsa049771.83070032
22PPAR signaling pathway_Homo sapiens_hsa033201.81639384
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.80855562
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.57868034
25Other glycan degradation_Homo sapiens_hsa005111.52440225
26Thyroid cancer_Homo sapiens_hsa052161.51211307
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.44145307
28Arginine and proline metabolism_Homo sapiens_hsa003301.42370058
29Ether lipid metabolism_Homo sapiens_hsa005651.42338673
30Sulfur metabolism_Homo sapiens_hsa009201.40804561
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.40096176
32Fat digestion and absorption_Homo sapiens_hsa049751.33292634
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.32358788
34Fatty acid degradation_Homo sapiens_hsa000711.29916305
35Phenylalanine metabolism_Homo sapiens_hsa003601.29560262
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.23991405
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18939890
38Chemical carcinogenesis_Homo sapiens_hsa052041.16087569
39Ovarian steroidogenesis_Homo sapiens_hsa049131.14723245
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04548632
41African trypanosomiasis_Homo sapiens_hsa051431.02334356
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.96848183
43Glycosaminoglycan degradation_Homo sapiens_hsa005310.93591388
44NF-kappa B signaling pathway_Homo sapiens_hsa040640.93497870
45Sphingolipid metabolism_Homo sapiens_hsa006000.91138461
46Inositol phosphate metabolism_Homo sapiens_hsa005620.89386992
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87355417
48Homologous recombination_Homo sapiens_hsa034400.86957592
49Primary immunodeficiency_Homo sapiens_hsa053400.84044140
50Hematopoietic cell lineage_Homo sapiens_hsa046400.84003723
51Folate biosynthesis_Homo sapiens_hsa007900.81851877
52Asthma_Homo sapiens_hsa053100.80064002
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.78917982
54Herpes simplex infection_Homo sapiens_hsa051680.76338975
55Basal cell carcinoma_Homo sapiens_hsa052170.75655650
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75352693
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74975900
58Taste transduction_Homo sapiens_hsa047420.73424775
59Tryptophan metabolism_Homo sapiens_hsa003800.73213654
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72966934
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70528931
62Retinol metabolism_Homo sapiens_hsa008300.69244685
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.68628009
64Starch and sucrose metabolism_Homo sapiens_hsa005000.67960422
65* Protein digestion and absorption_Homo sapiens_hsa049740.67906285
66Choline metabolism in cancer_Homo sapiens_hsa052310.67290578
67Graft-versus-host disease_Homo sapiens_hsa053320.65764878
68Peroxisome_Homo sapiens_hsa041460.62706361
69Staphylococcus aureus infection_Homo sapiens_hsa051500.62044882
70Tyrosine metabolism_Homo sapiens_hsa003500.61868934
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61090097
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59394036
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.58735962
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.57328509
75Regulation of autophagy_Homo sapiens_hsa041400.56239127
76Histidine metabolism_Homo sapiens_hsa003400.55561555
77Bile secretion_Homo sapiens_hsa049760.55299351
78Pentose phosphate pathway_Homo sapiens_hsa000300.54067426
79Pathways in cancer_Homo sapiens_hsa052000.53535767
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53164641
81Fatty acid metabolism_Homo sapiens_hsa012120.53024228
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52906686
83Serotonergic synapse_Homo sapiens_hsa047260.52350616
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51916869
85p53 signaling pathway_Homo sapiens_hsa041150.48831593
86Hepatitis C_Homo sapiens_hsa051600.48502952
87Pancreatic secretion_Homo sapiens_hsa049720.47849594
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47802011
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47649519
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47543605
91RNA degradation_Homo sapiens_hsa030180.47509738
92Apoptosis_Homo sapiens_hsa042100.47451235
93Influenza A_Homo sapiens_hsa051640.47180352
94Leishmaniasis_Homo sapiens_hsa051400.45172478
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44697414
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.44190939
97Biosynthesis of amino acids_Homo sapiens_hsa012300.44129984
98mRNA surveillance pathway_Homo sapiens_hsa030150.43131371
99Allograft rejection_Homo sapiens_hsa053300.41584692
100Rap1 signaling pathway_Homo sapiens_hsa040150.41106615
101Glycerolipid metabolism_Homo sapiens_hsa005610.40536821
102Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40277765
103Basal transcription factors_Homo sapiens_hsa030220.40129429
104Acute myeloid leukemia_Homo sapiens_hsa052210.39743551
105Insulin resistance_Homo sapiens_hsa049310.39001892
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38477873
107Sulfur relay system_Homo sapiens_hsa041220.37860569
108Complement and coagulation cascades_Homo sapiens_hsa046100.37735567
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37083009
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.35876229
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.35065297
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34976756
113Carbon metabolism_Homo sapiens_hsa012000.34017904
114Fatty acid biosynthesis_Homo sapiens_hsa000610.33472073
115One carbon pool by folate_Homo sapiens_hsa006700.33294066
116Hedgehog signaling pathway_Homo sapiens_hsa043400.33276732
117Autoimmune thyroid disease_Homo sapiens_hsa053200.32364792
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32297262
119Type I diabetes mellitus_Homo sapiens_hsa049400.32139896
120Renin secretion_Homo sapiens_hsa049240.31588206
121Non-homologous end-joining_Homo sapiens_hsa034500.31456766
122Pyruvate metabolism_Homo sapiens_hsa006200.31429915
123RNA transport_Homo sapiens_hsa030130.31167017
124Tight junction_Homo sapiens_hsa045300.30639184
125Glutathione metabolism_Homo sapiens_hsa004800.29485511
126Legionellosis_Homo sapiens_hsa051340.29370968
127Metabolic pathways_Homo sapiens_hsa011000.29329773
128MicroRNAs in cancer_Homo sapiens_hsa052060.28789633
129Notch signaling pathway_Homo sapiens_hsa043300.28483786
130ABC transporters_Homo sapiens_hsa020100.28244314
131Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28130841
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.27739523
133Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26532002
134Cell cycle_Homo sapiens_hsa041100.26307852
135Base excision repair_Homo sapiens_hsa034100.26157968
136Thyroid hormone synthesis_Homo sapiens_hsa049180.23106697
137Glucagon signaling pathway_Homo sapiens_hsa049220.22808092
138Cocaine addiction_Homo sapiens_hsa050300.22675603
139Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.20359668
140Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.18831261
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17166124
142Butanoate metabolism_Homo sapiens_hsa006500.16927832
143Antigen processing and presentation_Homo sapiens_hsa046120.16922984
144Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.16502874
145Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.14044255
146Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.12910880
147beta-Alanine metabolism_Homo sapiens_hsa004100.12345515
148Pertussis_Homo sapiens_hsa051330.08048653
149Fatty acid elongation_Homo sapiens_hsa000620.07764425
150Propanoate metabolism_Homo sapiens_hsa006400.07250650
151Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.05995116
152AMPK signaling pathway_Homo sapiens_hsa041520.05438134
153Insulin secretion_Homo sapiens_hsa049110.04736645
154Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.03041982
155Amphetamine addiction_Homo sapiens_hsa050310.02987296

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