XPNPEP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the family of X-pro-aminopeptidases that utilize a metal cofactor, and remove the N-terminal amino acid from peptides with a proline residue in the penultimate position. This protein has been shown to localize to the mitochondria of renal cells, and have a role in ciliary function. Mutations in this gene are associated with nephronophthisis-like nephropathy-1. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene, however, expression of some of these isoforms in vivo is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.12417400
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.12417400
3L-phenylalanine metabolic process (GO:0006558)5.56835886
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.56835886
5aromatic amino acid family catabolic process (GO:0009074)5.56071844
6serine family amino acid catabolic process (GO:0009071)5.35503766
7behavioral response to nicotine (GO:0035095)5.09111635
8tryptophan catabolic process (GO:0006569)4.95948103
9indole-containing compound catabolic process (GO:0042436)4.95948103
10indolalkylamine catabolic process (GO:0046218)4.95948103
11amino-acid betaine metabolic process (GO:0006577)4.89427789
12tryptophan metabolic process (GO:0006568)4.76229950
13urea cycle (GO:0000050)4.74647423
14urea metabolic process (GO:0019627)4.74647423
15glycine metabolic process (GO:0006544)4.53182317
16coenzyme catabolic process (GO:0009109)4.48395202
17dicarboxylic acid biosynthetic process (GO:0043650)4.42188467
18alpha-linolenic acid metabolic process (GO:0036109)4.39406738
19triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.34141563
20kynurenine metabolic process (GO:0070189)4.30511104
21nitrogen cycle metabolic process (GO:0071941)4.24262610
22regulation of protein activation cascade (GO:2000257)4.21917209
23bile acid biosynthetic process (GO:0006699)4.17569014
24triglyceride homeostasis (GO:0070328)4.11819948
25acylglycerol homeostasis (GO:0055090)4.11819948
26complement activation, alternative pathway (GO:0006957)4.10858419
27aromatic amino acid family metabolic process (GO:0009072)4.10807813
28serine family amino acid metabolic process (GO:0009069)4.08270116
29tyrosine metabolic process (GO:0006570)4.05063408
30alpha-amino acid catabolic process (GO:1901606)4.02508166
31regulation of complement activation (GO:0030449)3.96073248
32fucose catabolic process (GO:0019317)3.95916586
33L-fucose metabolic process (GO:0042354)3.95916586
34L-fucose catabolic process (GO:0042355)3.95916586
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.95585273
36homocysteine metabolic process (GO:0050667)3.92992765
37bile acid metabolic process (GO:0008206)3.92860239
38cellular ketone body metabolic process (GO:0046950)3.86413794
39glyoxylate metabolic process (GO:0046487)3.82505661
40cellular biogenic amine catabolic process (GO:0042402)3.79383174
41amine catabolic process (GO:0009310)3.79383174
42cysteine metabolic process (GO:0006534)3.76471683
43regulation of cholesterol metabolic process (GO:0090181)3.74867534
44sulfur amino acid catabolic process (GO:0000098)3.74702519
45water-soluble vitamin biosynthetic process (GO:0042364)3.74178888
46regulation of fibrinolysis (GO:0051917)3.73020509
47epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.71834770
48carnitine metabolic process (GO:0009437)3.71110439
49protein carboxylation (GO:0018214)3.70424720
50peptidyl-glutamic acid carboxylation (GO:0017187)3.70424720
51cellular amino acid catabolic process (GO:0009063)3.68429994
52fatty acid transmembrane transport (GO:1902001)3.67729296
53branched-chain amino acid catabolic process (GO:0009083)3.66599529
54epithelial cilium movement (GO:0003351)3.65939331
55indolalkylamine metabolic process (GO:0006586)3.65877362
56serine family amino acid biosynthetic process (GO:0009070)3.57063565
57regulation of nuclear cell cycle DNA replication (GO:0033262)3.53259289
58carnitine shuttle (GO:0006853)3.52769217
59negative regulation of fibrinolysis (GO:0051918)3.49795813
60ketone body metabolic process (GO:1902224)3.49128508
61fatty acid beta-oxidation (GO:0006635)3.48885717
62regulation of cholesterol biosynthetic process (GO:0045540)3.48446090
63ethanol oxidation (GO:0006069)3.48291033
64regulation of bile acid biosynthetic process (GO:0070857)3.47446113
65glutamate metabolic process (GO:0006536)3.45080069
66high-density lipoprotein particle remodeling (GO:0034375)3.44530291
67cilium movement (GO:0003341)3.44104276
68axoneme assembly (GO:0035082)3.40865263
69regulation of triglyceride catabolic process (GO:0010896)3.39333946
70regulation of sequestering of triglyceride (GO:0010889)3.38162926
71fatty acid oxidation (GO:0019395)3.36140037
72negative regulation of lipase activity (GO:0060192)3.35899698
73biotin metabolic process (GO:0006768)3.35367387
74linoleic acid metabolic process (GO:0043651)3.34323808
75organic acid catabolic process (GO:0016054)3.34218683
76carboxylic acid catabolic process (GO:0046395)3.34218683
77acetyl-CoA metabolic process (GO:0006084)3.34162572
78protein polyglutamylation (GO:0018095)3.33594830
79plasma lipoprotein particle clearance (GO:0034381)3.32447420
80lipid oxidation (GO:0034440)3.30542091
81branched-chain amino acid metabolic process (GO:0009081)3.29563756
82mitochondrial respiratory chain complex I assembly (GO:0032981)3.28045989
83NADH dehydrogenase complex assembly (GO:0010257)3.28045989
84mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.28045989
85nonmotile primary cilium assembly (GO:0035058)3.27736002
86very-low-density lipoprotein particle assembly (GO:0034379)3.27619751
87imidazole-containing compound metabolic process (GO:0052803)3.27500712
88protein complex biogenesis (GO:0070271)3.27062870
89L-serine metabolic process (GO:0006563)3.25852539
90nuclear pore complex assembly (GO:0051292)3.24678342
91positive regulation of fatty acid beta-oxidation (GO:0032000)3.23729365
92DNA deamination (GO:0045006)3.22875542
93lysine catabolic process (GO:0006554)3.22138277
94lysine metabolic process (GO:0006553)3.22138277
95cofactor catabolic process (GO:0051187)3.14087143
96fatty acid catabolic process (GO:0009062)3.13696950
97piRNA metabolic process (GO:0034587)3.12996116
98mitochondrial respiratory chain complex assembly (GO:0033108)3.12610743
99cytolysis (GO:0019835)3.12481820
100response to pheromone (GO:0019236)3.10270100
101regulation of mesoderm development (GO:2000380)3.09455793
102cellular glucuronidation (GO:0052695)3.09262410
103glutamine family amino acid biosynthetic process (GO:0009084)3.08250691
104detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.06753159
105regulation of hippo signaling (GO:0035330)3.04152698
106short-chain fatty acid metabolic process (GO:0046459)3.03153704
107NAD biosynthetic process (GO:0009435)3.03050969
108plasma lipoprotein particle remodeling (GO:0034369)3.01800774
109protein-lipid complex remodeling (GO:0034368)3.01800774
110macromolecular complex remodeling (GO:0034367)3.01800774
111nuclear pore organization (GO:0006999)3.01538814
112pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.01296871
113UMP metabolic process (GO:0046049)3.01296871
114pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.01296871
115UMP biosynthetic process (GO:0006222)3.01296871
116valine metabolic process (GO:0006573)3.01198040
117tetrahydrofolate metabolic process (GO:0046653)3.00752060
118monocarboxylic acid catabolic process (GO:0072329)2.98153383
119respiratory chain complex IV assembly (GO:0008535)2.97228253
120negative regulation of fatty acid biosynthetic process (GO:0045717)2.96504235
121reciprocal DNA recombination (GO:0035825)2.96203007
122reciprocal meiotic recombination (GO:0007131)2.96203007
123negative regulation of telomere maintenance (GO:0032205)2.96159058
124blood coagulation, intrinsic pathway (GO:0007597)2.95358358
125positive regulation of fatty acid oxidation (GO:0046321)2.95187543
126sulfation (GO:0051923)2.94609175
127aspartate family amino acid catabolic process (GO:0009068)2.93537537
128phospholipid homeostasis (GO:0055091)2.92619906
129nicotinamide nucleotide biosynthetic process (GO:0019359)2.92277118
130DNA methylation involved in gamete generation (GO:0043046)2.91534717
131kidney morphogenesis (GO:0060993)2.88184781
132cornea development in camera-type eye (GO:0061303)2.87302665
133double-strand break repair via homologous recombination (GO:0000724)2.83614136
134negative regulation of translation, ncRNA-mediated (GO:0040033)2.83307642
135regulation of translation, ncRNA-mediated (GO:0045974)2.83307642
136negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.83307642
137detection of light stimulus involved in visual perception (GO:0050908)2.82823422
138detection of light stimulus involved in sensory perception (GO:0050962)2.82823422
139recombinational repair (GO:0000725)2.82234313
140indole-containing compound metabolic process (GO:0042430)2.81665720
141cilium organization (GO:0044782)2.81104009
142platelet dense granule organization (GO:0060155)2.80317485
143centriole replication (GO:0007099)2.77869832
144negative regulation of DNA-dependent DNA replication (GO:2000104)2.76690340
145cilium assembly (GO:0042384)2.75684538
146regulation of gene silencing by RNA (GO:0060966)2.72969570
147regulation of posttranscriptional gene silencing (GO:0060147)2.72969570
148regulation of gene silencing by miRNA (GO:0060964)2.72969570
149replication fork processing (GO:0031297)2.70400607
150cilium morphogenesis (GO:0060271)2.69412175
151preassembly of GPI anchor in ER membrane (GO:0016254)2.68664365
152regulation of cilium movement (GO:0003352)2.66029773
153spinal cord motor neuron differentiation (GO:0021522)2.65939635
154rRNA catabolic process (GO:0016075)2.64313845
155synapsis (GO:0007129)2.63618230
156neural tube formation (GO:0001841)2.62791221
157reflex (GO:0060004)2.61481405
158cilium or flagellum-dependent cell motility (GO:0001539)2.60477244
159sperm motility (GO:0030317)2.58624143
160axonemal dynein complex assembly (GO:0070286)2.56043000
161mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.52925409
162pseudouridine synthesis (GO:0001522)2.52063076
163protein localization to cilium (GO:0061512)2.52009270
164primary amino compound metabolic process (GO:1901160)2.52000401
165regulation of rhodopsin mediated signaling pathway (GO:0022400)2.51706019
166regulation of hexokinase activity (GO:1903299)2.50110678
167regulation of glucokinase activity (GO:0033131)2.50110678
168behavioral response to ethanol (GO:0048149)2.49720234
169oxidative demethylation (GO:0070989)2.49616704
170somite development (GO:0061053)2.48547790
171regulation of meiosis I (GO:0060631)2.47770726
172rhodopsin mediated signaling pathway (GO:0016056)2.47026126
173DNA double-strand break processing (GO:0000729)2.45423996
174regulation of action potential (GO:0098900)2.44608970
175cytochrome complex assembly (GO:0017004)2.44224752
176serotonin metabolic process (GO:0042428)2.44199262
177male meiosis I (GO:0007141)2.43906585
178signal peptide processing (GO:0006465)2.43062056
179protein-cofactor linkage (GO:0018065)2.42869224
180photoreceptor cell maintenance (GO:0045494)2.42801543
181negative regulation of cytosolic calcium ion concentration (GO:0051481)2.42330079
182RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.40148677
183establishment of protein localization to Golgi (GO:0072600)2.39835193
184neuronal action potential (GO:0019228)2.39834075
185positive regulation of meiosis (GO:0045836)2.37937799
186L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.35764587
187ubiquinone biosynthetic process (GO:0006744)2.33721368
188regulation of DNA endoreduplication (GO:0032875)2.33547753
189gamma-aminobutyric acid transport (GO:0015812)2.33442240
190protein K11-linked deubiquitination (GO:0035871)2.32802692
191multicellular organism reproduction (GO:0032504)2.31684992
192protein K6-linked ubiquitination (GO:0085020)2.31534317

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.10461607
2EGR1_23403033_ChIP-Seq_LIVER_Mouse5.23646091
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.71599770
4ZNF274_21170338_ChIP-Seq_K562_Hela3.72160500
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.71343183
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.70326410
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.37363652
8E2F7_22180533_ChIP-Seq_HELA_Human3.28468045
9VDR_22108803_ChIP-Seq_LS180_Human3.21658000
10SALL1_21062744_ChIP-ChIP_HESCs_Human3.01816944
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.91979444
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.88023955
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.75048498
14IGF1R_20145208_ChIP-Seq_DFB_Human2.55938464
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.52784162
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.45372858
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.44426293
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.43043413
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.22201814
20GBX2_23144817_ChIP-Seq_PC3_Human2.19841372
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.17337804
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.14226889
23EZH2_22144423_ChIP-Seq_EOC_Human2.09952061
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.08191627
25* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06452752
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.98534606
27TP63_19390658_ChIP-ChIP_HaCaT_Human1.84341546
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.79933607
29KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.78305202
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77292307
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74461952
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.73187716
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.71955552
34IRF1_19129219_ChIP-ChIP_H3396_Human1.70288072
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.61016393
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.60491958
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59217289
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.57236079
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54732395
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.52710115
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51931805
42CBP_20019798_ChIP-Seq_JUKART_Human1.51931805
43EST1_17652178_ChIP-ChIP_JURKAT_Human1.51048965
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.50340329
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49723210
46AR_25329375_ChIP-Seq_VCAP_Human1.49284055
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46972583
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46965628
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46796183
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45758070
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44077160
52TP53_22573176_ChIP-Seq_HFKS_Human1.43722058
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43047374
54* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42789523
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40649850
56MYC_18940864_ChIP-ChIP_HL60_Human1.39720306
57* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.38832343
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.36447041
59NANOG_19829295_ChIP-Seq_ESCs_Human1.35387994
60SOX2_19829295_ChIP-Seq_ESCs_Human1.35387994
61TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.33674192
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32210122
63FOXA1_25329375_ChIP-Seq_VCAP_Human1.31925086
64FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31925086
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.28942266
66AR_21572438_ChIP-Seq_LNCaP_Human1.28814549
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.28466706
68TCF4_22108803_ChIP-Seq_LS180_Human1.28422965
69E2F4_17652178_ChIP-ChIP_JURKAT_Human1.28016874
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25847957
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25628031
72ELK1_19687146_ChIP-ChIP_HELA_Human1.24635566
73SMAD4_21741376_ChIP-Seq_EPCs_Human1.24058026
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.23889192
75KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22031366
76SUZ12_18555785_Chip-Seq_ESCs_Mouse1.21932296
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21289600
78P300_19829295_ChIP-Seq_ESCs_Human1.20765823
79TCF4_23295773_ChIP-Seq_U87_Human1.19807588
80STAT3_23295773_ChIP-Seq_U87_Human1.18577093
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17522053
82TCF4_18268006_ChIP-ChIP_LS174T_Human1.16978558
83* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16754700
84RUNX2_22187159_ChIP-Seq_PCA_Human1.16744880
85RUNX1_27457419_Chip-Seq_LIVER_Mouse1.16523384
86RNF2_27304074_Chip-Seq_NSC_Mouse1.16518322
87HOXB7_26014856_ChIP-Seq_BT474_Human1.16164693
88EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15688315
89TAF15_26573619_Chip-Seq_HEK293_Human1.15560473
90FUS_26573619_Chip-Seq_HEK293_Human1.14162195
91EWS_26573619_Chip-Seq_HEK293_Human1.14073654
92TP53_16413492_ChIP-PET_HCT116_Human1.13225570
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11791203
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.11734385
95GATA3_21878914_ChIP-Seq_MCF-7_Human1.11369826
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11065933
97NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10207647
98FOXA2_19822575_ChIP-Seq_HepG2_Human1.09718063
99FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09585883
100SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09292717
101OCT4_18555785_Chip-Seq_ESCs_Mouse1.08640324
102AR_20517297_ChIP-Seq_VCAP_Human1.08630541
103NCOR_22424771_ChIP-Seq_293T_Human1.08363116
104TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08052725
105FLI1_21867929_ChIP-Seq_TH2_Mouse1.07300575
106* VDR_23849224_ChIP-Seq_CD4+_Human1.06134908
107TCF3_18692474_ChIP-Seq_MESCs_Mouse1.06037489
108* HNF4A_19822575_ChIP-Seq_HepG2_Human1.06035998
109P300_18555785_Chip-Seq_ESCs_Mouse1.05939157
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05404156
111SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05293954
112CRX_20693478_ChIP-Seq_RETINA_Mouse1.05022702
113HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04947335
114OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04922437
115BCAT_22108803_ChIP-Seq_LS180_Human1.04540463
116E2F1_18555785_Chip-Seq_ESCs_Mouse1.04032839
117TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03395199
118AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02991305
119REST_21632747_ChIP-Seq_MESCs_Mouse1.02927784
120TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02891138
121STAT3_18555785_Chip-Seq_ESCs_Mouse1.02465722
122PRDM14_20953172_ChIP-Seq_ESCs_Human1.01436264
123STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00652733
124SMAD4_21799915_ChIP-Seq_A2780_Human0.99997990
125PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.99110387
126SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98814427
127SMAD_19615063_ChIP-ChIP_OVARY_Human0.98159973
128CDX2_22108803_ChIP-Seq_LS180_Human0.97822680
129GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97715081
130FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97456936
131P53_22387025_ChIP-Seq_ESCs_Mouse0.96704896
132KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.96309935
133KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.96309935
134KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.96309935
135OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94805727
136SOX2_18555785_Chip-Seq_ESCs_Mouse0.94721612
137HTT_18923047_ChIP-ChIP_STHdh_Human0.94464462
138KLF4_18555785_Chip-Seq_ESCs_Mouse0.94324906
139PHF8_20622853_ChIP-Seq_HELA_Human0.93407796
140ZFX_18555785_Chip-Seq_ESCs_Mouse0.93134785
141FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.92809752
142MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.91186092
143POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91049502
144TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91049502
145ESRRB_18555785_Chip-Seq_ESCs_Mouse0.90180846
146NFYB_21822215_ChIP-Seq_K562_Human0.90121834
147CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88964628
148STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88657938
149ER_23166858_ChIP-Seq_MCF-7_Human0.88655220
150PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88487741
151MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87600882
152NMYC_18555785_Chip-Seq_ESCs_Mouse0.87257141
153POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86790344

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.51879701
2MP0005085_abnormal_gallbladder_physiolo5.72180797
3MP0005365_abnormal_bile_salt5.65331024
4MP0005360_urolithiasis5.15666981
5MP0003806_abnormal_nucleotide_metabolis4.61912003
6MP0003252_abnormal_bile_duct3.42947026
7MP0005670_abnormal_white_adipose3.36083057
8MP0010329_abnormal_lipoprotein_level3.21073354
9MP0002837_dystrophic_cardiac_calcinosis3.18714802
10MP0008875_abnormal_xenobiotic_pharmacok3.12668356
11MP0003646_muscle_fatigue2.82409336
12MP0005332_abnormal_amino_acid2.77191393
13MP0002938_white_spotting2.31256251
14MP0003136_yellow_coat_color2.27087887
15MP0002102_abnormal_ear_morphology2.26221389
16MP0003195_calcinosis2.20403439
17MP0009697_abnormal_copulation2.15986939
18MP0004130_abnormal_muscle_cell2.07800531
19MP0002138_abnormal_hepatobiliary_system2.07641629
20MP0002118_abnormal_lipid_homeostasis2.01168668
21MP0006072_abnormal_retinal_apoptosis1.97779524
22MP0004019_abnormal_vitamin_homeostasis1.90158230
23MP0005666_abnormal_adipose_tissue1.89037009
24MP0001764_abnormal_homeostasis1.79734425
25MP0000631_abnormal_neuroendocrine_gland1.76978143
26MP0003868_abnormal_feces_composition1.76896879
27MP0009046_muscle_twitch1.74981285
28MP0000609_abnormal_liver_physiology1.74802854
29MP0002971_abnormal_brown_adipose1.72470995
30MP0005253_abnormal_eye_physiology1.70846653
31MP0002638_abnormal_pupillary_reflex1.69393851
32MP0006292_abnormal_olfactory_placode1.67948173
33MP0001485_abnormal_pinna_reflex1.67634901
34MP0001968_abnormal_touch/_nociception1.67525395
35MP0001661_extended_life_span1.66432330
36MP0004043_abnormal_pH_regulation1.65646630
37MP0001188_hyperpigmentation1.65640336
38MP0004885_abnormal_endolymph1.63962566
39MP0004142_abnormal_muscle_tone1.63665877
40MP0004133_heterotaxia1.61257633
41MP0002653_abnormal_ependyma_morphology1.56525626
42MP0005083_abnormal_biliary_tract1.55443691
43MP0003890_abnormal_embryonic-extraembry1.54779206
44MP0009840_abnormal_foam_cell1.51141538
45MP0002736_abnormal_nociception_after1.50726117
46MP0008872_abnormal_physiological_respon1.49943830
47MP0002160_abnormal_reproductive_system1.48382920
48MP0005645_abnormal_hypothalamus_physiol1.46679104
49MP0005319_abnormal_enzyme/_coenzyme1.45828010
50MP0002234_abnormal_pharynx_morphology1.44010156
51MP0009745_abnormal_behavioral_response1.43288333
52MP0004145_abnormal_muscle_electrophysio1.42375535
53MP0000372_irregular_coat_pigmentation1.39102319
54MP0004185_abnormal_adipocyte_glucose1.38036538
55MP0001666_abnormal_nutrient_absorption1.36522311
56MP0004147_increased_porphyrin_level1.35837502
57MP0001984_abnormal_olfaction1.33275755
58MP0003186_abnormal_redox_activity1.33225154
59MP0002272_abnormal_nervous_system1.31179281
60MP0005174_abnormal_tail_pigmentation1.28438475
61MP0004215_abnormal_myocardial_fiber1.24537781
62MP0005334_abnormal_fat_pad1.23668360
63MP0010094_abnormal_chromosome_stability1.23564684
64MP0005084_abnormal_gallbladder_morpholo1.23483161
65MP0010368_abnormal_lymphatic_system1.22913183
66MP0002876_abnormal_thyroid_physiology1.22408039
67MP0002735_abnormal_chemical_nociception1.19921179
68MP0000579_abnormal_nail_morphology1.19200362
69MP0001986_abnormal_taste_sensitivity1.18800791
70MP0002163_abnormal_gland_morphology1.18426232
71MP0005379_endocrine/exocrine_gland_phen1.18269258
72MP0003718_maternal_effect1.17765759
73MP0005389_reproductive_system_phenotype1.16024072
74MP0005375_adipose_tissue_phenotype1.15811055
75MP0005410_abnormal_fertilization1.15198918
76MP0001501_abnormal_sleep_pattern1.14779044
77MP0008058_abnormal_DNA_repair1.12655534
78MP0003119_abnormal_digestive_system1.12644366
79MP0001486_abnormal_startle_reflex1.12517158
80MP0009115_abnormal_fat_cell1.11448814
81MP0008789_abnormal_olfactory_epithelium1.10104921
82MP0003137_abnormal_impulse_conducting1.08524187
83MP0002928_abnormal_bile_duct1.07503405
84MP0002557_abnormal_social/conspecific_i1.06946555
85MP0006276_abnormal_autonomic_nervous1.05976216
86MP0005647_abnormal_sex_gland1.05145229
87MP0005408_hypopigmentation1.04211431
88MP0003787_abnormal_imprinting1.03422260
89MP0002970_abnormal_white_adipose1.01897672
90MP0005195_abnormal_posterior_eye1.00940646
91MP0000003_abnormal_adipose_tissue1.00290430
92MP0002095_abnormal_skin_pigmentation1.00195203
93MP0001324_abnormal_eye_pigmentation0.99887984
94MP0003698_abnormal_male_reproductive0.99610845
95MP0003828_pulmonary_edema0.99519650
96MP0008775_abnormal_heart_ventricle0.98801684
97MP0003878_abnormal_ear_physiology0.98606099
98MP0005377_hearing/vestibular/ear_phenot0.98606099
99MP0005535_abnormal_body_temperature0.97604409
100MP0001529_abnormal_vocalization0.97043347
101MP0005220_abnormal_exocrine_pancreas0.96165456
102MP0001929_abnormal_gametogenesis0.96055191
103MP0003959_abnormal_lean_body0.95520960
104MP0008057_abnormal_DNA_replication0.94538179
105MP0005386_behavior/neurological_phenoty0.93615232
106MP0004924_abnormal_behavior0.93615232
107MP0002572_abnormal_emotion/affect_behav0.93499539
108MP0003690_abnormal_glial_cell0.93358945
109MP0005266_abnormal_metabolism0.93229252
110MP0005551_abnormal_eye_electrophysiolog0.92504080
111MP0009765_abnormal_xenobiotic_induced0.92306836
112MP0002210_abnormal_sex_determination0.91854018
113MP0002078_abnormal_glucose_homeostasis0.90835401
114MP0000598_abnormal_liver_morphology0.90480825
115MP0003950_abnormal_plasma_membrane0.90179304
116MP0005075_abnormal_melanosome_morpholog0.89877381
117MP0005646_abnormal_pituitary_gland0.89394745
118MP0002064_seizures0.89371973
119MP0000569_abnormal_digit_pigmentation0.88426164
120MP0000026_abnormal_inner_ear0.88032758
121MP0004742_abnormal_vestibular_system0.87126994
122MP0009763_increased_sensitivity_to0.86390612
123MP0001970_abnormal_pain_threshold0.86204243
124MP0003656_abnormal_erythrocyte_physiolo0.85789189
125MP0002733_abnormal_thermal_nociception0.85704638
126MP0003111_abnormal_nucleus_morphology0.85682359
127MP0000230_abnormal_systemic_arterial0.84571326
128MP0002067_abnormal_sensory_capabilities0.84203457
129MP0002751_abnormal_autonomic_nervous0.83791369
130MP0009764_decreased_sensitivity_to0.83173597
131MP0003283_abnormal_digestive_organ0.82896869
132MP0001293_anophthalmia0.82069164
133MP0002909_abnormal_adrenal_gland0.81215659
134MP0004085_abnormal_heartbeat0.81022457
135MP0005448_abnormal_energy_balance0.80407578
136MP0005391_vision/eye_phenotype0.80319680
137MP0002752_abnormal_somatic_nervous0.80125673
138MP0009643_abnormal_urine_homeostasis0.78085922
139MP0001919_abnormal_reproductive_system0.77680420
140MP0000049_abnormal_middle_ear0.77108131
141MP0000653_abnormal_sex_gland0.76907614
142MP0000778_abnormal_nervous_system0.76209749
143MP0005584_abnormal_enzyme/coenzyme_acti0.76048177
144MP0003943_abnormal_hepatobiliary_system0.74590686
145MP0005376_homeostasis/metabolism_phenot0.73933689
146MP0000383_abnormal_hair_follicle0.73911652
147MP0008877_abnormal_DNA_methylation0.73743447
148MP0005395_other_phenotype0.72826553
149MP0005171_absent_coat_pigmentation0.70850056
150MP0002332_abnormal_exercise_endurance0.70619300
151MP0001672_abnormal_embryogenesis/_devel0.70286249
152MP0005380_embryogenesis_phenotype0.70286249
153MP0009703_decreased_birth_body0.70174567
154MP0006035_abnormal_mitochondrial_morpho0.63991306
155MP0000015_abnormal_ear_pigmentation0.63808915
156MP0000427_abnormal_hair_cycle0.63496245
157MP0009642_abnormal_blood_homeostasis0.62817089
158MP0001879_abnormal_lymphatic_vessel0.61114517
159MP0005452_abnormal_adipose_tissue0.60561615
160MP0002108_abnormal_muscle_morphology0.59943608
161MP0010386_abnormal_urinary_bladder0.59542056
162MP0005248_abnormal_Harderian_gland0.59402323
163MP0003011_delayed_dark_adaptation0.59008334
164MP0004197_abnormal_fetal_growth/weight/0.57026128
165MP0002697_abnormal_eye_size0.56168643
166MP0000613_abnormal_salivary_gland0.56004206
167MP0001286_abnormal_eye_development0.55710191
168MP0001177_atelectasis0.54941404
169MP0003699_abnormal_female_reproductive0.52165226
170MP0002088_abnormal_embryonic_growth/wei0.52119081
171MP0002269_muscular_atrophy0.51332638
172MP0002086_abnormal_extraembryonic_tissu0.51218873
173MP0003984_embryonic_growth_retardation0.51178353
174MP0003937_abnormal_limbs/digits/tail_de0.50226556
175MP0001119_abnormal_female_reproductive0.49911747

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.23809514
2Intrahepatic cholestasis (HP:0001406)4.96246280
3Hyperlipoproteinemia (HP:0010980)4.60103220
4Hypobetalipoproteinemia (HP:0003563)4.34620568
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.15512527
6Pancreatic fibrosis (HP:0100732)4.14491958
7Prolonged partial thromboplastin time (HP:0003645)4.13407910
8Abnormality of midbrain morphology (HP:0002418)4.11517464
9Molar tooth sign on MRI (HP:0002419)4.11517464
10Hyperglycinemia (HP:0002154)4.09209368
11Deep venous thrombosis (HP:0002625)4.03915249
12* Pancreatic cysts (HP:0001737)4.00722150
13Xanthomatosis (HP:0000991)3.99136679
14Hypophosphatemic rickets (HP:0004912)3.99078284
15Abnormality of pyrimidine metabolism (HP:0004353)3.95237748
16Hypoglycemic coma (HP:0001325)3.94051203
17Abnormality of methionine metabolism (HP:0010901)3.91997653
18Epidermoid cyst (HP:0200040)3.85779819
19Hyperglycinuria (HP:0003108)3.85639682
20Ketosis (HP:0001946)3.82188960
21Renal cortical cysts (HP:0000803)3.79433808
22Abnormality of glycine metabolism (HP:0010895)3.72691668
23Abnormality of serine family amino acid metabolism (HP:0010894)3.72691668
24True hermaphroditism (HP:0010459)3.72625740
25Abnormality of sulfur amino acid metabolism (HP:0004339)3.68029403
26Hypoglycemic seizures (HP:0002173)3.53906865
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.48158985
28Abnormality of aspartate family amino acid metabolism (HP:0010899)3.42860809
29Complement deficiency (HP:0004431)3.41301196
30Hypochromic microcytic anemia (HP:0004840)3.39877128
31* Nephronophthisis (HP:0000090)3.39702547
32Hyperammonemia (HP:0001987)3.30218399
33Abnormality of the common coagulation pathway (HP:0010990)3.29567447
34Congenital stationary night blindness (HP:0007642)3.23200317
35Enlarged kidneys (HP:0000105)3.21378659
36Hypolipoproteinemia (HP:0010981)3.20131906
37Joint hemorrhage (HP:0005261)3.08111143
38* Abnormality of the renal medulla (HP:0100957)3.03270605
39Chromosomal breakage induced by crosslinking agents (HP:0003221)3.02588007
40Type II lissencephaly (HP:0007260)2.99637016
41Abnormality of serum amino acid levels (HP:0003112)2.87449122
42Abnormal biliary tract physiology (HP:0012439)2.83599278
43Bile duct proliferation (HP:0001408)2.83599278
44Conjugated hyperbilirubinemia (HP:0002908)2.81682183
45Hypercholesterolemia (HP:0003124)2.81498968
46Osteomalacia (HP:0002749)2.79638323
47Medial flaring of the eyebrow (HP:0010747)2.78446674
48Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.76707743
49Abnormality of alanine metabolism (HP:0010916)2.76707743
50Hyperalaninemia (HP:0003348)2.76707743
51Cystic liver disease (HP:0006706)2.74076820
52Toxemia of pregnancy (HP:0100603)2.71799463
53Hypoalphalipoproteinemia (HP:0003233)2.68751042
54Hyperventilation (HP:0002883)2.68513743
55Abnormal ciliary motility (HP:0012262)2.68198139
56Duplicated collecting system (HP:0000081)2.64546546
57* Abnormality of the renal cortex (HP:0011035)2.63796544
58Hyperinsulinemic hypoglycemia (HP:0000825)2.63363041
59Attenuation of retinal blood vessels (HP:0007843)2.61465332
60Abnormality of fatty-acid metabolism (HP:0004359)2.60843635
61Generalized aminoaciduria (HP:0002909)2.58601414
62Abnormality of dicarboxylic acid metabolism (HP:0010995)2.55465894
63Dicarboxylic aciduria (HP:0003215)2.55465894
64Pendular nystagmus (HP:0012043)2.52302217
65Fat malabsorption (HP:0002630)2.51143119
66Chromsome breakage (HP:0040012)2.50908506
67Abnormal respiratory epithelium morphology (HP:0012253)2.47040905
68Abnormal respiratory motile cilium morphology (HP:0005938)2.47040905
69Sclerocornea (HP:0000647)2.45719415
70Cerebral edema (HP:0002181)2.45461284
71Polydipsia (HP:0001959)2.45277951
72Abnormal drinking behavior (HP:0030082)2.45277951
73Aplasia/Hypoplasia of the tibia (HP:0005772)2.45035483
74Abnormality of glutamine family amino acid metabolism (HP:0010902)2.43247146
75Abnormality of nucleobase metabolism (HP:0010932)2.41714803
76Inability to walk (HP:0002540)2.41519414
77Sensory axonal neuropathy (HP:0003390)2.41445380
78Furrowed tongue (HP:0000221)2.40579825
79Abnormality of the intrinsic pathway (HP:0010989)2.39055528
80Birth length less than 3rd percentile (HP:0003561)2.37576608
81Rickets (HP:0002748)2.35053093
82Abolished electroretinogram (ERG) (HP:0000550)2.33151911
83Congenital, generalized hypertrichosis (HP:0004540)2.33145863
84Lethargy (HP:0001254)2.32551244
85Abnormal respiratory motile cilium physiology (HP:0012261)2.32113409
86Brushfield spots (HP:0001088)2.31970698
87Symptomatic seizures (HP:0011145)2.30772788
88Impulsivity (HP:0100710)2.28489036
89Abnormality of the renal collecting system (HP:0004742)2.26923933
90Cerebellar dysplasia (HP:0007033)2.26794548
91Anencephaly (HP:0002323)2.24515712
92Aplasia/Hypoplasia of the tongue (HP:0010295)2.24220261
93Large for gestational age (HP:0001520)2.23247994
94Gaze-evoked nystagmus (HP:0000640)2.22101023
95Hepatocellular carcinoma (HP:0001402)2.21422720
96Limb hypertonia (HP:0002509)2.19723362
97* Tubular atrophy (HP:0000092)2.19424605
98Pigmentary retinal degeneration (HP:0001146)2.18837319
99Thyroid-stimulating hormone excess (HP:0002925)2.18165101
100Chorioretinal atrophy (HP:0000533)2.17325653
101Myocardial infarction (HP:0001658)2.17172241
102Chronic hepatic failure (HP:0100626)2.15875701
103Congenital hepatic fibrosis (HP:0002612)2.15533999
104Concave nail (HP:0001598)2.15321431
105Aplasia/Hypoplasia of the patella (HP:0006498)2.14769542
106Patellar aplasia (HP:0006443)2.13731616
107Progressive inability to walk (HP:0002505)2.13564127
108Microvesicular hepatic steatosis (HP:0001414)2.12911592
109Gait imbalance (HP:0002141)2.12766054
110Congenital primary aphakia (HP:0007707)2.12622973
111Long foot (HP:0001833)2.10529766
112Fair hair (HP:0002286)2.10024665
113Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.08816894
114Increased CSF lactate (HP:0002490)2.08749482
115Abnormality of the pons (HP:0007361)2.07143436
116Opisthotonus (HP:0002179)2.05713351
117Acute necrotizing encephalopathy (HP:0006965)2.05701781
118Colon cancer (HP:0003003)2.04337694
119Genetic anticipation (HP:0003743)2.04328636
120Mitochondrial inheritance (HP:0001427)2.04165945
121Postaxial foot polydactyly (HP:0001830)2.03803729
122Keratoconus (HP:0000563)2.03570374
123Increased corneal curvature (HP:0100692)2.03570374
124Hypoplasia of the pons (HP:0012110)2.03557891
125Optic nerve hypoplasia (HP:0000609)2.02504478
126Decreased circulating renin level (HP:0003351)2.01572355
127Alveolar cell carcinoma (HP:0006519)2.01104981
128Hypertriglyceridemia (HP:0002155)2.00680444
129Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.00410242
130Pseudobulbar signs (HP:0002200)2.00255604
131Lissencephaly (HP:0001339)1.99025471
132Male pseudohermaphroditism (HP:0000037)1.97051980
133Broad-based gait (HP:0002136)1.96956188
134Genital tract atresia (HP:0001827)1.95043225
135Polyuria (HP:0000103)1.94971362
136Upper motor neuron abnormality (HP:0002127)1.94687779
137Nephrogenic diabetes insipidus (HP:0009806)1.94542521
138Neoplasm of the tracheobronchial system (HP:0100552)1.92195009
139Acute encephalopathy (HP:0006846)1.91694349
140Progressive cerebellar ataxia (HP:0002073)1.91219053
141Methylmalonic acidemia (HP:0002912)1.90719126
142Bony spicule pigmentary retinopathy (HP:0007737)1.90415286
143Pancreatic islet-cell hyperplasia (HP:0004510)1.89550730
144Steatorrhea (HP:0002570)1.87307008
145Neoplasm of the liver (HP:0002896)1.87067526
146Vaginal atresia (HP:0000148)1.86953603
147Metabolic acidosis (HP:0001942)1.86269605
148Decreased central vision (HP:0007663)1.84400478
149Absent thumb (HP:0009777)1.83686379
150Progressive macrocephaly (HP:0004481)1.83604309
151Rhinitis (HP:0012384)1.83181102
152Abnormality of complement system (HP:0005339)1.82591877
153Abnormality of the hepatic vasculature (HP:0006707)1.82425223
154Hypothermia (HP:0002045)1.82403045
155Abnormality of the ileum (HP:0001549)1.82248365
156Ketoacidosis (HP:0001993)1.81971434
157Abnormal rod and cone electroretinograms (HP:0008323)1.81078900
158Submucous cleft hard palate (HP:0000176)1.80958966
159Preaxial hand polydactyly (HP:0001177)1.80514070
160Proximal tubulopathy (HP:0000114)1.79976443
161Clitoromegaly (HP:0000057)1.79709945
162Short tibia (HP:0005736)1.79620759
163Delayed CNS myelination (HP:0002188)1.77533419
164Poor coordination (HP:0002370)1.77177185
165Confusion (HP:0001289)1.76892727
166Meckel diverticulum (HP:0002245)1.76777098
167Ectopic kidney (HP:0000086)1.76531222
168Decreased electroretinogram (ERG) amplitude (HP:0000654)1.76431342
169Abnormality of the labia minora (HP:0012880)1.75893493
170Portal hypertension (HP:0001409)1.75142002
171Neoplasm of the adrenal cortex (HP:0100641)1.74761892
172Congenital sensorineural hearing impairment (HP:0008527)1.74748510
173Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.72939826
174Hepatic necrosis (HP:0002605)1.72754972
175Dandy-Walker malformation (HP:0001305)1.72452904
176Postaxial hand polydactyly (HP:0001162)1.71860429
177Rib fusion (HP:0000902)1.71661974
178Aplasia/Hypoplasia of the uvula (HP:0010293)1.71128258
179Absent/shortened dynein arms (HP:0200106)1.70898288
180Dynein arm defect of respiratory motile cilia (HP:0012255)1.70898288
181Skin nodule (HP:0200036)1.70729442
182Abnormality of homocysteine metabolism (HP:0010919)1.68853086
183Homocystinuria (HP:0002156)1.68853086
184Spastic diplegia (HP:0001264)1.68399131
185Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.66240633
186Glycosuria (HP:0003076)1.64961067
187Abnormality of urine glucose concentration (HP:0011016)1.64961067

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK44.68132282
2AKT33.69471510
3BMPR1B3.40021632
4TIE13.23855905
5INSRR3.19015643
6BCKDK3.11185767
7ICK3.02840868
8ADRBK22.60832831
9NUAK12.47619364
10ZAK2.41177632
11SIK12.41083006
12FGFR22.39582311
13FGFR42.24444057
14WNK42.20630443
15WNK32.15962756
16MAP4K22.15840668
17FRK2.03641377
18IRAK31.85140334
19TAOK21.84000481
20CDK121.83543248
21STK38L1.82353054
22PLK21.77477209
23EIF2AK21.74903115
24ERBB41.72638941
25MKNK21.59743806
26MAP3K41.58978884
27STK391.55241041
28OXSR11.54039854
29MKNK11.51421250
30TNIK1.47217118
31MAPK111.46175716
32TAF11.44272938
33BRD41.43970305
34CASK1.43854733
35SGK21.42063023
36MAPK131.40940941
37TRIM281.39185660
38TGFBR11.31963473
39YES11.31557810
40FGFR31.30954437
41EIF2AK11.28049784
42CAMK1D1.27517874
43PNCK1.25558971
44TTK1.24391350
45BRSK21.19562102
46VRK11.17430735
47BRAF1.17294649
48VRK21.15765900
49PDK31.15294556
50PDK41.15294556
51NME11.12988160
52SGK31.11698917
53MAP3K141.10619354
54LATS11.10003461
55GRK11.08654381
56ADRBK11.06280512
57MST41.04471995
58PAK31.03968304
59STK161.03611813
60CAMK1G1.03516293
61WEE11.02201173
62DAPK20.96230223
63TAOK30.91756764
64NLK0.90611157
65PHKG10.89728964
66PHKG20.89728964
67PDGFRB0.88524005
68FGFR10.87221063
69DYRK20.87152926
70PIK3CA0.86784252
71MTOR0.86416555
72OBSCN0.85070626
73PBK0.84706587
74SRPK10.84076951
75PRKCE0.83086301
76CDK30.82597101
77STK30.82082276
78CDC70.80590168
79NEK20.79833454
80PRKCG0.79317769
81NEK60.78665038
82SGK2230.74960106
83SGK4940.74960106
84MAP2K70.74501353
85MET0.74453419
86MAPKAPK50.72257837
87PTK2B0.71087246
88MAPK150.70138295
89PLK30.69522357
90STK40.69103662
91MUSK0.68912099
92MAP3K30.67373076
93PKN10.67253446
94CSNK1G10.66410103
95CHEK20.66370609
96ACVR1B0.65992743
97NTRK30.65475443
98BUB10.64890986
99PLK10.63994939
100TXK0.62864815
101TSSK60.61802586
102AURKB0.60774160
103PRKAA10.60630114
104CSNK1G20.60269564
105CHEK10.60268998
106ATR0.60014378
107PRKAA20.59906244
108CSNK1G30.55853352
109TGFBR20.55552843
110PTK60.55087634
111AKT20.53794026
112RPS6KA50.53790046
113PDGFRA0.53345908
114MAP2K60.52301325
115MARK10.51575992
116CAMKK20.51023736
117STK110.49291475
118PDK20.48927474
119CSNK1A1L0.48510590
120GRK70.47529229
121CDK10.47345656
122ATM0.46456527
123PRKCQ0.45923463
124MAPKAPK30.44521444
125SGK10.44264518
126CAMK10.42615523
127CSNK1E0.42444185
128FLT30.42014839
129CAMK2A0.40829646
130PRKACA0.40533563
131PIK3CG0.40388525
132PINK10.39981444
133ERBB30.39482158
134CHUK0.39167235
135CSNK1A10.38727217
136EIF2AK30.38640363
137RPS6KB10.38581386
138MAP2K10.38397679
139PRKCI0.37796006
140FER0.37342180
141BCR0.37333617
142EPHA20.34983080
143TLK10.34562862
144MAPK70.34490434
145EPHA40.34150586
146AKT10.34068107
147MELK0.33848789
148TEC0.33458356
149WNK10.32867770
150MAPK10.31651955
151INSR0.31507539
152CDK70.30933378
153PASK0.30426234
154NEK90.29819012
155CCNB10.29463412
156MAP2K30.27760061
157MAPK140.26611616
158PRKACG0.26602502
159CDK60.26545207

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.39292242
2Fatty acid degradation_Homo sapiens_hsa000713.10042544
3Nitrogen metabolism_Homo sapiens_hsa009102.95793661
4Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.83122552
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.65360627
6Phototransduction_Homo sapiens_hsa047442.60668618
7Tryptophan metabolism_Homo sapiens_hsa003802.55341558
8Fatty acid metabolism_Homo sapiens_hsa012122.52464023
9Propanoate metabolism_Homo sapiens_hsa006402.48292894
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.48017162
11Arginine biosynthesis_Homo sapiens_hsa002202.37030603
12Oxidative phosphorylation_Homo sapiens_hsa001902.36889843
13Peroxisome_Homo sapiens_hsa041462.32646824
14Complement and coagulation cascades_Homo sapiens_hsa046102.28757192
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.27239260
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.22760347
17Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.17579218
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.16665619
19PPAR signaling pathway_Homo sapiens_hsa033202.09613507
20beta-Alanine metabolism_Homo sapiens_hsa004102.03381692
21Phenylalanine metabolism_Homo sapiens_hsa003602.03242987
22One carbon pool by folate_Homo sapiens_hsa006702.01909565
23Vitamin B6 metabolism_Homo sapiens_hsa007501.99677055
24Protein export_Homo sapiens_hsa030601.96508773
25Histidine metabolism_Homo sapiens_hsa003401.93924357
26Butanoate metabolism_Homo sapiens_hsa006501.91669022
27Tyrosine metabolism_Homo sapiens_hsa003501.84405576
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.81478718
29Parkinsons disease_Homo sapiens_hsa050121.80699061
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.80062925
31Selenocompound metabolism_Homo sapiens_hsa004501.78907768
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.69703626
33Nicotine addiction_Homo sapiens_hsa050331.69507102
34Steroid biosynthesis_Homo sapiens_hsa001001.68294195
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.67954035
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.67284267
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.66424373
38Fatty acid elongation_Homo sapiens_hsa000621.65973569
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.59156082
40Retinol metabolism_Homo sapiens_hsa008301.55361045
41Huntingtons disease_Homo sapiens_hsa050161.52192094
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.49148157
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.47909313
44Lysine degradation_Homo sapiens_hsa003101.43383346
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.42737126
46Folate biosynthesis_Homo sapiens_hsa007901.40773230
47Staphylococcus aureus infection_Homo sapiens_hsa051501.36925499
48Chemical carcinogenesis_Homo sapiens_hsa052041.36054963
49RNA degradation_Homo sapiens_hsa030181.35437818
50Ether lipid metabolism_Homo sapiens_hsa005651.32809866
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32028812
52Pyruvate metabolism_Homo sapiens_hsa006201.27867864
53Vitamin digestion and absorption_Homo sapiens_hsa049771.26908997
54Cardiac muscle contraction_Homo sapiens_hsa042601.25106864
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22441741
56Alzheimers disease_Homo sapiens_hsa050101.20084657
57Taste transduction_Homo sapiens_hsa047421.19790973
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.19423999
59Biosynthesis of amino acids_Homo sapiens_hsa012301.13267372
60Sulfur metabolism_Homo sapiens_hsa009201.12795035
61ABC transporters_Homo sapiens_hsa020101.12536663
62Ribosome_Homo sapiens_hsa030101.12026410
63Fatty acid biosynthesis_Homo sapiens_hsa000611.02831023
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01937834
65Olfactory transduction_Homo sapiens_hsa047401.01765898
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.99717812
67Arginine and proline metabolism_Homo sapiens_hsa003300.98734179
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98399028
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97965868
70Caffeine metabolism_Homo sapiens_hsa002320.97560873
71Carbon metabolism_Homo sapiens_hsa012000.96420521
72Starch and sucrose metabolism_Homo sapiens_hsa005000.96197899
73Morphine addiction_Homo sapiens_hsa050320.94266843
74Glycerolipid metabolism_Homo sapiens_hsa005610.93302573
75Insulin secretion_Homo sapiens_hsa049110.88145458
76Pentose phosphate pathway_Homo sapiens_hsa000300.87153015
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85658263
78Arachidonic acid metabolism_Homo sapiens_hsa005900.85224945
79Serotonergic synapse_Homo sapiens_hsa047260.84996448
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82585101
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80486568
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80395420
83Fanconi anemia pathway_Homo sapiens_hsa034600.80209398
84Bile secretion_Homo sapiens_hsa049760.79587391
85Nucleotide excision repair_Homo sapiens_hsa034200.79038879
86Sulfur relay system_Homo sapiens_hsa041220.77745498
87Regulation of autophagy_Homo sapiens_hsa041400.74824624
88Ovarian steroidogenesis_Homo sapiens_hsa049130.72291950
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72224539
90GABAergic synapse_Homo sapiens_hsa047270.70216020
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70192566
92Glutamatergic synapse_Homo sapiens_hsa047240.67296749
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66752057
94Circadian entrainment_Homo sapiens_hsa047130.65893870
95Proteasome_Homo sapiens_hsa030500.64473258
96Calcium signaling pathway_Homo sapiens_hsa040200.63530081
97Hedgehog signaling pathway_Homo sapiens_hsa043400.63163354
98Basal cell carcinoma_Homo sapiens_hsa052170.62512402
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61543499
100Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.61182728
101Mismatch repair_Homo sapiens_hsa034300.59064479
102Insulin resistance_Homo sapiens_hsa049310.56194681
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.54444064
104Metabolic pathways_Homo sapiens_hsa011000.53500163
105Dorso-ventral axis formation_Homo sapiens_hsa043200.51118977
106Circadian rhythm_Homo sapiens_hsa047100.44593231
107Fat digestion and absorption_Homo sapiens_hsa049750.42404960
108Homologous recombination_Homo sapiens_hsa034400.42401584
109Mineral absorption_Homo sapiens_hsa049780.41551079
110Salivary secretion_Homo sapiens_hsa049700.39887658
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39632836
112p53 signaling pathway_Homo sapiens_hsa041150.39306365
113Sphingolipid metabolism_Homo sapiens_hsa006000.38762769
114Fructose and mannose metabolism_Homo sapiens_hsa000510.37955661
115Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37389404
116Systemic lupus erythematosus_Homo sapiens_hsa053220.36896073
117Pyrimidine metabolism_Homo sapiens_hsa002400.36102768
118Prion diseases_Homo sapiens_hsa050200.35464202
119AMPK signaling pathway_Homo sapiens_hsa041520.34875971
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34470520
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29560210
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.27983987
123Glutathione metabolism_Homo sapiens_hsa004800.24106197
124Basal transcription factors_Homo sapiens_hsa030220.22321545
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.22050825
126Linoleic acid metabolism_Homo sapiens_hsa005910.21514950
127Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.21280117
128NF-kappa B signaling pathway_Homo sapiens_hsa040640.20514772
129Glucagon signaling pathway_Homo sapiens_hsa049220.20260736
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19830028
131Cyanoamino acid metabolism_Homo sapiens_hsa004600.19616185
132Insulin signaling pathway_Homo sapiens_hsa049100.12340155
133Non-homologous end-joining_Homo sapiens_hsa034500.10942839
134RNA transport_Homo sapiens_hsa030130.09767249
135Melanoma_Homo sapiens_hsa052180.09564539
136Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.08374100
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.07311395
138Purine metabolism_Homo sapiens_hsa002300.06622123
139RNA polymerase_Homo sapiens_hsa030200.05999980
140mRNA surveillance pathway_Homo sapiens_hsa030150.03429241
141Prostate cancer_Homo sapiens_hsa052150.02465246
142Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.01952094
143MicroRNAs in cancer_Homo sapiens_hsa05206-0.0206415

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