XPO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.94260580
2nuclear pore organization (GO:0006999)5.91716359
3protein localization to kinetochore (GO:0034501)5.23179439
4DNA unwinding involved in DNA replication (GO:0006268)5.16150870
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.83140887
6mitotic chromosome condensation (GO:0007076)4.74113827
7mitotic sister chromatid cohesion (GO:0007064)4.46904205
8pore complex assembly (GO:0046931)4.45876098
9mitotic metaphase plate congression (GO:0007080)4.43305984
10sister chromatid segregation (GO:0000819)4.35799356
11protein localization to chromosome, centromeric region (GO:0071459)4.33808105
12mitotic nuclear envelope disassembly (GO:0007077)4.33522390
13kinetochore organization (GO:0051383)4.28515049
14DNA replication initiation (GO:0006270)4.25432089
15DNA replication-dependent nucleosome organization (GO:0034723)4.22971938
16DNA replication-dependent nucleosome assembly (GO:0006335)4.22971938
17regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.20685348
18mitotic sister chromatid segregation (GO:0000070)4.13914950
19nuclear envelope disassembly (GO:0051081)4.11522289
20membrane disassembly (GO:0030397)4.11522289
21metaphase plate congression (GO:0051310)4.06502134
22regulation of histone H3-K9 methylation (GO:0051570)3.97800836
23pre-miRNA processing (GO:0031054)3.95638346
24attachment of spindle microtubules to kinetochore (GO:0008608)3.95037065
25establishment of integrated proviral latency (GO:0075713)3.91798504
26DNA geometric change (GO:0032392)3.90301713
27DNA duplex unwinding (GO:0032508)3.90087640
28chromatin remodeling at centromere (GO:0031055)3.89250422
29positive regulation of chromosome segregation (GO:0051984)3.87268279
30IMP biosynthetic process (GO:0006188)3.86301750
31regulation of spindle organization (GO:0090224)3.85439526
32DNA replication checkpoint (GO:0000076)3.82551812
33positive regulation of mitotic sister chromatid separation (GO:1901970)3.76329066
34positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.76329066
35positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.76329066
36CENP-A containing nucleosome assembly (GO:0034080)3.76003325
37negative regulation of histone methylation (GO:0031061)3.74026530
38DNA strand elongation involved in DNA replication (GO:0006271)3.73040860
39regulation of sister chromatid cohesion (GO:0007063)3.71801001
40DNA replication-independent nucleosome assembly (GO:0006336)3.69942469
41DNA replication-independent nucleosome organization (GO:0034724)3.69942469
42regulation of translational fidelity (GO:0006450)3.65911376
43double-strand break repair via nonhomologous end joining (GO:0006303)3.65399318
44non-recombinational repair (GO:0000726)3.65399318
45regulation of RNA export from nucleus (GO:0046831)3.64230316
46establishment of chromosome localization (GO:0051303)3.62955336
47paraxial mesoderm development (GO:0048339)3.62081521
48nucleobase biosynthetic process (GO:0046112)3.61711914
49regulation of helicase activity (GO:0051095)3.60146979
50regulation of centriole replication (GO:0046599)3.56587395
51heterochromatin organization (GO:0070828)3.54203568
52regulation of chromosome segregation (GO:0051983)3.53486950
53DNA strand elongation (GO:0022616)3.53261590
54spindle checkpoint (GO:0031577)3.52702054
55chromatin assembly (GO:0031497)3.52677457
56meiotic chromosome segregation (GO:0045132)3.52142648
57dosage compensation (GO:0007549)3.51356544
58DNA synthesis involved in DNA repair (GO:0000731)3.51221633
59regulation of posttranscriptional gene silencing (GO:0060147)3.51184587
60regulation of gene silencing by miRNA (GO:0060964)3.51184587
61regulation of gene silencing by RNA (GO:0060966)3.51184587
62regulation of mitotic spindle organization (GO:0060236)3.49246069
63protein localization to chromosome (GO:0034502)3.46617344
64chromatin assembly or disassembly (GO:0006333)3.46493722
65histone exchange (GO:0043486)3.46170082
66protein complex localization (GO:0031503)3.46028634
67kinetochore assembly (GO:0051382)3.43378458
68regulation of mitotic metaphase/anaphase transition (GO:0030071)3.42746106
69spindle assembly checkpoint (GO:0071173)3.41300559
70mitotic recombination (GO:0006312)3.40291957
71IMP metabolic process (GO:0046040)3.39936851
72DNA topological change (GO:0006265)3.38572818
73negative regulation of chromosome segregation (GO:0051985)3.36846526
74mitotic spindle checkpoint (GO:0071174)3.35201173
75DNA ligation (GO:0006266)3.33619217
76regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.33579221
77negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.32202888
78negative regulation of sister chromatid segregation (GO:0033046)3.32202888
79negative regulation of mitotic sister chromatid separation (GO:2000816)3.32202888
80negative regulation of mitotic sister chromatid segregation (GO:0033048)3.32202888
81mitotic spindle assembly checkpoint (GO:0007094)3.31344253
82DNA conformation change (GO:0071103)3.30340508
83purine nucleobase biosynthetic process (GO:0009113)3.28746030
84regulation of mitotic sister chromatid separation (GO:0010965)3.28355541
85regulation of mitotic sister chromatid segregation (GO:0033047)3.28355541
86regulation of sister chromatid segregation (GO:0033045)3.28355541
87chromosome segregation (GO:0007059)3.27277234
88somatic hypermutation of immunoglobulin genes (GO:0016446)3.25572507
89somatic diversification of immune receptors via somatic mutation (GO:0002566)3.25572507
90folic acid-containing compound biosynthetic process (GO:0009396)3.25342134
91telomere maintenance via semi-conservative replication (GO:0032201)3.23066257
92histone H2A monoubiquitination (GO:0035518)3.21844167
93cellular protein complex localization (GO:0034629)3.21146287
94negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.20649955
95ATP-dependent chromatin remodeling (GO:0043044)3.19775847
96chromosome condensation (GO:0030261)3.19256221
97sister chromatid cohesion (GO:0007062)3.19092085
98regulation of nucleobase-containing compound transport (GO:0032239)3.18859335
99DNA packaging (GO:0006323)3.18348869
100nuclear envelope organization (GO:0006998)3.17909821
101regulation of translational termination (GO:0006449)3.17171413
102protein K6-linked ubiquitination (GO:0085020)3.14273028
103telomere maintenance via recombination (GO:0000722)3.13495171
104regulation of DNA endoreduplication (GO:0032875)3.12234057
105formation of translation preinitiation complex (GO:0001731)3.10947975
106regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.10920078
107ribosome assembly (GO:0042255)3.05949972
108* regulation of centrosome cycle (GO:0046605)3.05143805
109negative regulation of DNA repair (GO:0045738)3.04893586
110negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.04867029
111microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.04300421
112spindle assembly involved in mitosis (GO:0090307)3.02948171
113monoubiquitinated protein deubiquitination (GO:0035520)3.02330181
114NLS-bearing protein import into nucleus (GO:0006607)3.02131168
115positive regulation of cell cycle checkpoint (GO:1901978)2.91948062
116* regulation of centrosome duplication (GO:0010824)2.86999719
117* mRNA transport (GO:0051028)2.82942397
118notochord development (GO:0030903)2.81953844
119V(D)J recombination (GO:0033151)2.76361614
120regulation of DNA damage checkpoint (GO:2000001)2.73521147

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.01081520
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.61534724
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.64352587
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.62840516
5* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.23534723
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.13622000
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.93545774
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.80725703
9AR_21909140_ChIP-Seq_LNCAP_Human2.58971004
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.54100526
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51451121
12* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.38120334
13* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34687858
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.31421849
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.24713141
16MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.18328009
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.14457698
18E2F7_22180533_ChIP-Seq_HELA_Human11.1457694
19MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93121881
20* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.89943668
21* XRN2_22483619_ChIP-Seq_HELA_Human1.88795599
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.84637994
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.81692295
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79484375
25POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.79180840
26YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76169702
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75626499
28TP63_19390658_ChIP-ChIP_HaCaT_Human1.74565974
29SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.73744619
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.72300871
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.70174952
32* MYC_22102868_ChIP-Seq_BL_Human1.69051950
33VDR_23849224_ChIP-Seq_CD4+_Human1.61074058
34SOX2_18555785_ChIP-Seq_MESCs_Mouse1.58605985
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57593940
36TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.55618626
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.52975608
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52283693
39* ELK1_19687146_ChIP-ChIP_HELA_Human1.51583238
40CIITA_25753668_ChIP-Seq_RAJI_Human1.47585289
41ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47331275
42* TTF2_22483619_ChIP-Seq_HELA_Human1.47316573
43KDM5A_27292631_Chip-Seq_BREAST_Human1.47090863
44GABP_17652178_ChIP-ChIP_JURKAT_Human1.43360857
45FOXP3_21729870_ChIP-Seq_TREG_Human1.42933823
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41602392
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.41497069
48KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.39220712
49KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.39220712
50KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.39220712
51* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.36406505
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36263359
53* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.36124107
54HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.35420071
55SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.35291415
56DCP1A_22483619_ChIP-Seq_HELA_Human1.32438209
57WT1_19549856_ChIP-ChIP_CCG9911_Human1.31663353
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31316507
59SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.27076655
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26785051
61* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25879416
62GABP_19822575_ChIP-Seq_HepG2_Human1.25181888
63* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.24425274
64ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.22025509
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20929494
66ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19636656
67* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17917924
68* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17541492
69ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16643661
70SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.14680389
71JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.14552577
72* NANOG_21062744_ChIP-ChIP_HESCs_Human1.13784381
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12841061
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12828094
75NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.12671048
76CLOCK_20551151_ChIP-Seq_293T_Human1.12376746
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12320857
78* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12231925
79TCF3_18692474_ChIP-Seq_MEFs_Mouse1.12152612
80SOX17_20123909_ChIP-Seq_XEN_Mouse1.11909395
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11499504
82TCF3_18692474_ChIP-Seq_MESCs_Mouse1.08694972
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08577389
84* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07807211
85FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.07301995
86NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.06141176
87TFEB_21752829_ChIP-Seq_HELA_Human1.03851387
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02596768
89* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95998248
90* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95787745
91ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.93899348
92SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93628596
93PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93353242
94CHD1_26751641_Chip-Seq_LNCaP_Human0.93249995
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93109814
96ZNF263_19887448_ChIP-Seq_K562_Human0.92926663
97SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92070727
98FUS_26573619_Chip-Seq_HEK293_Human0.90063319
99* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89684038
100* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88810849
101CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88381514
102* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.87569654
103NANOG_16153702_ChIP-ChIP_HESCs_Human0.86791561
104SOX2_16153702_ChIP-ChIP_HESCs_Human0.86590233
105NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.86247731
106ELF1_17652178_ChIP-ChIP_JURKAT_Human0.85788222
107SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85273778
108* SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.85096154
109EWS_26573619_Chip-Seq_HEK293_Human0.83405625
110SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82858044
111* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.82356793
112* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.80607831
113POU5F1_16153702_ChIP-ChIP_HESCs_Human0.80281353
114MYC_18940864_ChIP-ChIP_HL60_Human0.79372843
115* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.78260508
116HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.76560065

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.36331787
2MP0008057_abnormal_DNA_replication4.09945265
3MP0003111_abnormal_nucleus_morphology4.04828714
4MP0003693_abnormal_embryo_hatching3.93376810
5MP0004957_abnormal_blastocyst_morpholog3.69649406
6MP0003077_abnormal_cell_cycle3.58911761
7MP0003123_paternal_imprinting3.10376092
8MP0010352_gastrointestinal_tract_polyps2.75546351
9MP0008058_abnormal_DNA_repair2.73897393
10MP0008007_abnormal_cellular_replicative2.50528593
11MP0008877_abnormal_DNA_methylation2.50165027
12MP0002009_preneoplasia2.48874894
13MP0010307_abnormal_tumor_latency2.48604061
14MP0001730_embryonic_growth_arrest2.45464112
15MP0003121_genomic_imprinting2.40096707
16MP0000350_abnormal_cell_proliferation2.31771586
17MP0008932_abnormal_embryonic_tissue2.29126180
18MP0000537_abnormal_urethra_morphology2.02409904
19MP0001672_abnormal_embryogenesis/_devel2.02258086
20MP0005380_embryogenesis_phenotype2.02258086
21MP0003705_abnormal_hypodermis_morpholog1.99625238
22MP0005076_abnormal_cell_differentiation1.97235513
23MP0002084_abnormal_developmental_patter1.96065699
24MP0004197_abnormal_fetal_growth/weight/1.95774227
25MP0009697_abnormal_copulation1.94407970
26MP0001697_abnormal_embryo_size1.92503855
27MP0002085_abnormal_embryonic_tissue1.87003120
28MP0003890_abnormal_embryonic-extraembry1.86844849
29MP0003984_embryonic_growth_retardation1.82437776
30MP0002088_abnormal_embryonic_growth/wei1.79657141
31MP0002086_abnormal_extraembryonic_tissu1.74991261
32MP0002396_abnormal_hematopoietic_system1.73878700
33MP0003567_abnormal_fetal_cardiomyocyte1.73561087
34MP0009053_abnormal_anal_canal1.64598117
35MP0002080_prenatal_lethality1.59866307
36MP0003786_premature_aging1.58522379
37MP0003787_abnormal_imprinting1.55407480
38MP0004185_abnormal_adipocyte_glucose1.53393261
39MP0001293_anophthalmia1.51233908
40MP0003937_abnormal_limbs/digits/tail_de1.42679998
41MP0010234_abnormal_vibrissa_follicle1.40709359
42MP0010030_abnormal_orbit_morphology1.36997582
43MP0004808_abnormal_hematopoietic_stem1.36313096
44MP0003119_abnormal_digestive_system1.31856383
45MP0009703_decreased_birth_body1.27128991
46MP0002210_abnormal_sex_determination1.26756461
47MP0009672_abnormal_birth_weight1.23755500
48MP0001299_abnormal_eye_distance/1.17616239
49MP0000313_abnormal_cell_death1.17148481
50MP0003315_abnormal_perineum_morphology1.15152526
51MP0000569_abnormal_digit_pigmentation1.14123163
52MP0000566_synostosis1.13834945
53MP0001661_extended_life_span1.12983263
54MP0000428_abnormal_craniofacial_morphol1.11361671
55MP0000490_abnormal_crypts_of1.09888226
56MP0001145_abnormal_male_reproductive1.09397054
57MP0003941_abnormal_skin_development1.04750972
58MP0002019_abnormal_tumor_incidence1.03753010
59MP0002092_abnormal_eye_morphology1.02380992
60MP0005623_abnormal_meninges_morphology1.01941093
61MP0001915_intracranial_hemorrhage1.01339364
62MP0001346_abnormal_lacrimal_gland1.01325442
63MP0002697_abnormal_eye_size0.99847158
64MP0003115_abnormal_respiratory_system0.99593337
65MP0002233_abnormal_nose_morphology0.99234012
66MP0001849_ear_inflammation0.98510756
67MP0002111_abnormal_tail_morphology0.96541275
68MP0003935_abnormal_craniofacial_develop0.95920882
69MP0000516_abnormal_urinary_system0.95604370
70MP0005367_renal/urinary_system_phenotyp0.95604370
71MP0000579_abnormal_nail_morphology0.94457904
72MP0001286_abnormal_eye_development0.93564979
73MP0000432_abnormal_head_morphology0.93268394
74MP0003861_abnormal_nervous_system0.92932937
75MP0000733_abnormal_muscle_development0.91079704
76MP0003943_abnormal_hepatobiliary_system0.90753107
77MP0001929_abnormal_gametogenesis0.90236355
78MP0004272_abnormal_basement_membrane0.90143793
79MP0000653_abnormal_sex_gland0.90027203
80MP0003566_abnormal_cell_adhesion0.89514218
81MP0003755_abnormal_palate_morphology0.86928274
82MP0000383_abnormal_hair_follicle0.86410923
83MP0002925_abnormal_cardiovascular_devel0.85307340
84MP0002653_abnormal_ependyma_morphology0.82980369
85MP0000762_abnormal_tongue_morphology0.81667342
86MP0000703_abnormal_thymus_morphology0.79624794
87MP0004233_abnormal_muscle_weight0.78759371
88MP0003122_maternal_imprinting0.77873250
89MP0003718_maternal_effect0.77619552
90MP0003385_abnormal_body_wall0.76462041
91MP0002796_impaired_skin_barrier0.75994092
92MP0006054_spinal_hemorrhage0.75684618
93MP0001177_atelectasis0.75024239
94MP0005384_cellular_phenotype0.72685523
95MP0010630_abnormal_cardiac_muscle0.71081786
96MP0002938_white_spotting0.70539167
97MP0005621_abnormal_cell_physiology0.70419150
98MP0006292_abnormal_olfactory_placode0.70343576
99MP0005187_abnormal_penis_morphology0.69672512
100MP0002006_tumorigenesis0.69259588
101MP0009278_abnormal_bone_marrow0.68699621
102MP0000358_abnormal_cell_content/0.68439951
103MP0003942_abnormal_urinary_system0.68386583
104MP0004264_abnormal_extraembryonic_tissu0.67965451
105MP0001119_abnormal_female_reproductive0.67960804
106MP0000647_abnormal_sebaceous_gland0.67539005
107MP0000534_abnormal_ureter_morphology0.67440613
108MP0002160_abnormal_reproductive_system0.67216252
109MP0002114_abnormal_axial_skeleton0.66835267
110MP0000377_abnormal_hair_follicle0.66459964
111MP0002877_abnormal_melanocyte_morpholog0.65502792
112MP0003221_abnormal_cardiomyocyte_apopto0.64972785
113MP0005397_hematopoietic_system_phenotyp0.63660547
114MP0001545_abnormal_hematopoietic_system0.63660547
115MP0002081_perinatal_lethality0.62068964
116MP0010678_abnormal_skin_adnexa0.61974487
117MP0002282_abnormal_trachea_morphology0.61869528
118MP0000266_abnormal_heart_morphology0.61534143
119MP0002932_abnormal_joint_morphology0.61069850
120MP0005023_abnormal_wound_healing0.60766190
121MP0003936_abnormal_reproductive_system0.59729018
122MP0004133_heterotaxia0.59479136

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.84322927
2Chromsome breakage (HP:0040012)3.51288166
3Medulloblastoma (HP:0002885)3.42872165
4Colon cancer (HP:0003003)3.42242662
5Birth length less than 3rd percentile (HP:0003561)3.32849343
6Volvulus (HP:0002580)3.31752675
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.28362046
8Abnormality of the labia minora (HP:0012880)3.24018566
9Selective tooth agenesis (HP:0001592)3.21740669
10Abnormality of the astrocytes (HP:0100707)3.15369935
11Astrocytoma (HP:0009592)3.15369935
12Abnormality of chromosome stability (HP:0003220)2.98134477
13Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.93686073
14Short 4th metacarpal (HP:0010044)2.93686073
15Increased nuchal translucency (HP:0010880)2.88702303
16Cortical dysplasia (HP:0002539)2.84095102
17Deviation of the thumb (HP:0009603)2.80598313
18Proximal placement of thumb (HP:0009623)2.80042563
19Rhabdomyosarcoma (HP:0002859)2.79144592
20Impulsivity (HP:0100710)2.73859051
21Glioma (HP:0009733)2.71393682
22Patellar aplasia (HP:0006443)2.64950952
23Neoplasm of the oral cavity (HP:0100649)2.60713169
24Ectopic kidney (HP:0000086)2.60688187
25Agnosia (HP:0010524)2.50692722
26Facial hemangioma (HP:0000329)2.50497672
27Meckel diverticulum (HP:0002245)2.48388231
28Aplasia/Hypoplasia of the patella (HP:0006498)2.47310311
29Ankyloglossia (HP:0010296)2.46587366
30Absent radius (HP:0003974)2.38790102
31Biliary tract neoplasm (HP:0100574)2.37529780
32Breast hypoplasia (HP:0003187)2.37008157
33Missing ribs (HP:0000921)2.35840106
34Abnormality of the ileum (HP:0001549)2.34888947
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.34776792
36Nephroblastoma (Wilms tumor) (HP:0002667)2.33723502
37Abnormal number of incisors (HP:0011064)2.32271426
38Asymmetry of the thorax (HP:0001555)2.29632455
39Termporal pattern (HP:0011008)2.28840110
40Insidious onset (HP:0003587)2.28840110
41Supernumerary spleens (HP:0009799)2.27132534
42Neoplasm of striated muscle (HP:0009728)2.26137030
43Small intestinal stenosis (HP:0012848)2.25474971
44Duodenal stenosis (HP:0100867)2.25474971
45Abnormal lung lobation (HP:0002101)2.24778308
46Myelodysplasia (HP:0002863)2.24745495
47Aplasia involving forearm bones (HP:0009822)2.23416311
48Absent forearm bone (HP:0003953)2.23416311
49Embryonal renal neoplasm (HP:0011794)2.22123487
50Leiomyosarcoma (HP:0100243)2.21745840
51Uterine leiomyosarcoma (HP:0002891)2.21745840
52Degeneration of anterior horn cells (HP:0002398)2.21648003
53Abnormality of the anterior horn cell (HP:0006802)2.21648003
54Aplasia/Hypoplasia of the sternum (HP:0006714)2.20619821
55Gastrointestinal carcinoma (HP:0002672)2.20395043
56Malignant gastrointestinal tract tumors (HP:0006749)2.20395043
57Abnormality of the preputium (HP:0100587)2.18877467
58Atresia of the external auditory canal (HP:0000413)2.15244970
59Vertebral arch anomaly (HP:0008438)2.12868648
60Acute myeloid leukemia (HP:0004808)2.12176593
61Cafe-au-lait spot (HP:0000957)2.10215281
62Embryonal neoplasm (HP:0002898)2.10176486
63Basal cell carcinoma (HP:0002671)2.10092002
64Abnormality of the 4th metacarpal (HP:0010012)2.07925649
65Duplication of thumb phalanx (HP:0009942)2.05525435
66Transitional cell carcinoma of the bladder (HP:0006740)2.05360408
67Prominent nose (HP:0000448)2.04685778
68High anterior hairline (HP:0009890)2.04585764
6911 pairs of ribs (HP:0000878)2.02071292
70Esophageal atresia (HP:0002032)2.00864477
71Progressive external ophthalmoplegia (HP:0000590)2.00015372
72Skull defect (HP:0001362)1.99920525
73Spinal cord lesions (HP:0100561)1.98497698
74Syringomyelia (HP:0003396)1.98497698
75Abnormality of the duodenum (HP:0002246)1.97578481
76Pelvic girdle muscle weakness (HP:0003749)1.96970361
77Renal duplication (HP:0000075)1.96770636
78Sandal gap (HP:0001852)1.95806908
79Obsessive-compulsive behavior (HP:0000722)1.95169833
80Abnormality of oral frenula (HP:0000190)1.95146725
81Abnormality of the carotid arteries (HP:0005344)1.94743598
82Neoplasm of the pancreas (HP:0002894)1.94388028
83Reticulocytopenia (HP:0001896)1.93776437
84Hyperacusis (HP:0010780)1.93009785
85Sloping forehead (HP:0000340)1.92965667
86High pitched voice (HP:0001620)1.92761854
87Amaurosis fugax (HP:0100576)1.91965609
88Heterotopia (HP:0002282)1.91345877
89Ovarian neoplasm (HP:0100615)1.90678854
90Shoulder girdle muscle weakness (HP:0003547)1.89806824
91Aplasia/hypoplasia of the humerus (HP:0006507)1.89448050
92Bladder neoplasm (HP:0009725)1.89404921
93Bladder carcinoma (HP:0002862)1.89404921
94Deep philtrum (HP:0002002)1.88146484
95Short humerus (HP:0005792)1.86671006
96Abnormality of chromosome segregation (HP:0002916)1.86270910
97Spastic diplegia (HP:0001264)1.85734882
98Abnormality of the lower motor neuron (HP:0002366)1.85103521
99Hepatoblastoma (HP:0002884)1.84756705
100Absent thumb (HP:0009777)1.84474734
101Abnormality of the fingertips (HP:0001211)1.83372907
102Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.83106690
103Insomnia (HP:0100785)1.82457395
104Overriding aorta (HP:0002623)1.81340950
105Supernumerary ribs (HP:0005815)1.80524553
106Papillary thyroid carcinoma (HP:0002895)1.80328119
107Tracheoesophageal fistula (HP:0002575)1.78937570
108Short thumb (HP:0009778)1.78713876
109Shawl scrotum (HP:0000049)1.77407194
110Capillary hemangiomas (HP:0005306)1.77239158
111Choanal atresia (HP:0000453)1.77131197
112Long eyelashes (HP:0000527)1.76721133
113Abnormality of the distal phalanx of the thumb (HP:0009617)1.76345553
114Relative macrocephaly (HP:0004482)1.76236473
115Arteriovenous malformation (HP:0100026)1.76064301
116Neoplasm of the small intestine (HP:0100833)1.75381413
117Gastrointestinal atresia (HP:0002589)1.75076325
118Abnormality of the calcaneus (HP:0008364)1.74562815
119Broad thumb (HP:0011304)1.73165011
120Neoplasm of the colon (HP:0100273)1.71919604
121Subacute progressive viral hepatitis (HP:0006572)1.70251944
122Supernumerary bones of the axial skeleton (HP:0009144)1.69346598
123Cutaneous melanoma (HP:0012056)1.69126270
124Broad palm (HP:0001169)1.68162505
125Uterine neoplasm (HP:0010784)1.66872355
126Truncal obesity (HP:0001956)1.66858293
127Intestinal polyp (HP:0005266)1.66761999
128Freckling (HP:0001480)1.66642737
129Intestinal polyposis (HP:0200008)1.66513091
130Overlapping toe (HP:0001845)1.66281862
131Spinal muscular atrophy (HP:0007269)1.65314925
132Arnold-Chiari malformation (HP:0002308)1.64479399
133Trigonocephaly (HP:0000243)1.59856092
134Abnormality of the salivary glands (HP:0010286)1.57989506
135Renovascular hypertension (HP:0100817)1.57715892
136Triphalangeal thumb (HP:0001199)1.57545067
137Hypopigmentation of the fundus (HP:0007894)1.56813873
138Dysmetric saccades (HP:0000641)1.56158775
139Facial cleft (HP:0002006)1.54477899
140Anal stenosis (HP:0002025)1.54149715
141Omphalocele (HP:0001539)1.53765779
142Pseudobulbar signs (HP:0002200)1.52221858
143Clubbing of toes (HP:0100760)1.49124385

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.88889826
2WEE13.86723890
3CDK123.45139196
4NEK23.24289890
5SRPK12.96728298
6NEK12.80660464
7BUB12.61331887
8TTK2.61054601
9MKNK12.53521472
10BRSK22.40431137
11TSSK62.21430361
12PBK2.19358494
13PLK32.08842922
14PLK12.01144584
15ACVR1B1.90334049
16PASK1.87030159
17EIF2AK11.86656382
18SMG11.85996019
19EEF2K1.83628670
20ATR1.81380494
21MKNK21.81311620
22TAF11.73278696
23BRD41.70017866
24AURKB1.66779783
25LATS11.63303201
26CHEK11.59543769
27RPS6KB21.57952386
28CHEK21.57663556
29PLK41.56913136
30PKN21.56650895
31CDK41.45438664
32CDK71.43844063
33SCYL21.41554151
34ICK1.40165804
35ALK1.35494866
36MAP3K81.33526941
37STK101.33187951
38DYRK31.32442942
39PNCK1.32023932
40STK31.30513188
41ATM1.28205847
42BRSK11.27024160
43CDK61.21501963
44CAMK1G1.19844953
45RPS6KA41.18912343
46TGFBR11.16926474
47MAP3K101.16228929
48EPHA21.14318681
49ZAK1.13478034
50STK41.10756737
51CDK21.08998128
52TLK11.07650075
53TRIB30.99473179
54MELK0.94785834
55CDK10.90916830
56FGFR20.90865225
57EIF2AK30.90708806
58AURKA0.89040871
59VRK10.88140422
60MST1R0.86355696
61CAMK1D0.85943445
62MTOR0.80391949
63KSR20.79594838
64CCNB10.79501622
65FGFR10.78140822
66PAK40.78048678
67LATS20.77727602
68ERBB30.77625586
69ERBB40.74905249
70CSNK1D0.70900003
71BRAF0.70776047
72FGFR40.70196780
73STK38L0.67279157
74TTN0.66904469
75KSR10.65650438
76PIM10.63738559
77PDGFRA0.63139979
78FLT30.62648763
79PRKDC0.61801812
80STK240.61520651
81CSNK2A20.59350240
82BMX0.57929883
83CLK10.56560478
84CSNK1E0.54364560
85PTK60.52059953
86MAPK140.49129341
87MARK30.48932910
88MAP3K20.48804454
89NEK90.48054095
90MAP3K90.47011943
91PAK20.45158642
92EIF2AK20.43581979
93WNK10.43511070
94CSNK2A10.42847810
95LRRK20.42704360
96RPS6KB10.42590125
97AKT30.42467690
98NEK60.41902923
99RPS6KA50.41755456
100CDK90.41450118
101AKT20.40056626
102RET0.38811825
103CDK30.38259180
104RAF10.38097343
105BCR0.36938652
106GSK3B0.36382510
107AKT10.36353947
108PRKCI0.34631862
109PAK10.30759362
110YES10.30326372
111TYRO30.29928152
112MAPK10.28367687
113CSNK1A1L0.27422586
114TESK20.27373515
115PLK20.27292460
116MET0.27131461
117FGFR30.26080756
118MAPK100.25525174
119MAPK80.23347762
120PDGFRB0.22452346
121CDK80.20743773
122CHUK0.20655188

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.21190327
2Mismatch repair_Homo sapiens_hsa034303.98180237
3* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.53727883
4* RNA transport_Homo sapiens_hsa030133.39699470
5Cell cycle_Homo sapiens_hsa041103.32511473
6Spliceosome_Homo sapiens_hsa030403.27538892
7Base excision repair_Homo sapiens_hsa034102.65079079
8One carbon pool by folate_Homo sapiens_hsa006702.64906817
9Nucleotide excision repair_Homo sapiens_hsa034202.63411849
10mRNA surveillance pathway_Homo sapiens_hsa030152.59273783
11Homologous recombination_Homo sapiens_hsa034402.59009920
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.38680073
13Fanconi anemia pathway_Homo sapiens_hsa034602.37656869
14Non-homologous end-joining_Homo sapiens_hsa034502.07775344
15RNA degradation_Homo sapiens_hsa030181.98975485
16RNA polymerase_Homo sapiens_hsa030201.96695333
17Basal transcription factors_Homo sapiens_hsa030221.84519833
18Systemic lupus erythematosus_Homo sapiens_hsa053221.80165196
19p53 signaling pathway_Homo sapiens_hsa041151.72849568
20Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.65785604
21Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.51613215
22Viral carcinogenesis_Homo sapiens_hsa052031.50999170
23Oocyte meiosis_Homo sapiens_hsa041141.49520315
24MicroRNAs in cancer_Homo sapiens_hsa052061.47042556
25Pyrimidine metabolism_Homo sapiens_hsa002401.42584426
26Proteasome_Homo sapiens_hsa030501.25526300
27Antigen processing and presentation_Homo sapiens_hsa046121.18914003
28* Epstein-Barr virus infection_Homo sapiens_hsa051691.16851905
29Small cell lung cancer_Homo sapiens_hsa052221.15939893
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.15150390
31Hippo signaling pathway_Homo sapiens_hsa043901.12484817
32Herpes simplex infection_Homo sapiens_hsa051681.10914694
33* HTLV-I infection_Homo sapiens_hsa051661.09660300
34Ribosome_Homo sapiens_hsa030101.08824373
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07670890
36Colorectal cancer_Homo sapiens_hsa052101.03970430
37Adherens junction_Homo sapiens_hsa045201.03246698
38TGF-beta signaling pathway_Homo sapiens_hsa043501.02263872
39Basal cell carcinoma_Homo sapiens_hsa052170.99588771
40Thyroid cancer_Homo sapiens_hsa052160.97268672
41Alcoholism_Homo sapiens_hsa050340.95667570
42Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90998194
43mTOR signaling pathway_Homo sapiens_hsa041500.89841492
44Chronic myeloid leukemia_Homo sapiens_hsa052200.88742127
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86970903
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85578203
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84593694
48ErbB signaling pathway_Homo sapiens_hsa040120.82661858
49Viral myocarditis_Homo sapiens_hsa054160.77146956
50Lysine degradation_Homo sapiens_hsa003100.76034715
51Carbon metabolism_Homo sapiens_hsa012000.74657584
52Prostate cancer_Homo sapiens_hsa052150.73972733
53Purine metabolism_Homo sapiens_hsa002300.73785696
54Steroid biosynthesis_Homo sapiens_hsa001000.71759354
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71621290
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71396514
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.70015294
58Pentose phosphate pathway_Homo sapiens_hsa000300.69954211
59Hedgehog signaling pathway_Homo sapiens_hsa043400.67178325
60Endometrial cancer_Homo sapiens_hsa052130.66278918
61Proteoglycans in cancer_Homo sapiens_hsa052050.65280215
62Pyruvate metabolism_Homo sapiens_hsa006200.65193296
63Notch signaling pathway_Homo sapiens_hsa043300.64950791
64Vitamin B6 metabolism_Homo sapiens_hsa007500.64254552
65Pathways in cancer_Homo sapiens_hsa052000.62985505
66Inositol phosphate metabolism_Homo sapiens_hsa005620.62716438
67Hepatitis B_Homo sapiens_hsa051610.61330082
68Tight junction_Homo sapiens_hsa045300.60207620
69Pancreatic cancer_Homo sapiens_hsa052120.59382876
70Non-small cell lung cancer_Homo sapiens_hsa052230.58771702
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58068572
72Selenocompound metabolism_Homo sapiens_hsa004500.56770590
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56472412
74Insulin signaling pathway_Homo sapiens_hsa049100.53776327
75Wnt signaling pathway_Homo sapiens_hsa043100.52895499
76Apoptosis_Homo sapiens_hsa042100.51674012
77Bladder cancer_Homo sapiens_hsa052190.50725051
78Legionellosis_Homo sapiens_hsa051340.50701749
79HIF-1 signaling pathway_Homo sapiens_hsa040660.47840556
80Melanogenesis_Homo sapiens_hsa049160.47541874
81FoxO signaling pathway_Homo sapiens_hsa040680.47298646
82Choline metabolism in cancer_Homo sapiens_hsa052310.47187265
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46632643
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44592867
85Focal adhesion_Homo sapiens_hsa045100.44478595
86Melanoma_Homo sapiens_hsa052180.43029981
87Estrogen signaling pathway_Homo sapiens_hsa049150.42588733
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42239577
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40990419
90Measles_Homo sapiens_hsa051620.40396720
91Biosynthesis of amino acids_Homo sapiens_hsa012300.40190807
92Renal cell carcinoma_Homo sapiens_hsa052110.40000885
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38555229
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.37822156
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37812210
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37532839
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36941984
98Acute myeloid leukemia_Homo sapiens_hsa052210.35880641
99Prolactin signaling pathway_Homo sapiens_hsa049170.35738085
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.35241956
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34717478
102* Influenza A_Homo sapiens_hsa051640.33597793
103Glioma_Homo sapiens_hsa052140.32875792
104Shigellosis_Homo sapiens_hsa051310.32753020
105Thyroid hormone synthesis_Homo sapiens_hsa049180.29987055
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.29835461
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29705198
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29666412
109ECM-receptor interaction_Homo sapiens_hsa045120.26695826
110Toxoplasmosis_Homo sapiens_hsa051450.25505544
111Cyanoamino acid metabolism_Homo sapiens_hsa004600.24622232
112AMPK signaling pathway_Homo sapiens_hsa041520.23411086
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23355643
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.22051425
115N-Glycan biosynthesis_Homo sapiens_hsa005100.21010467
116T cell receptor signaling pathway_Homo sapiens_hsa046600.20159303
117Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.19970107
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.19787248
119B cell receptor signaling pathway_Homo sapiens_hsa046620.17863699
120Rap1 signaling pathway_Homo sapiens_hsa040150.17830597
121Dorso-ventral axis formation_Homo sapiens_hsa043200.17162409
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.16962427
123Primary immunodeficiency_Homo sapiens_hsa053400.16733115

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