XPO4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)7.47587794
2actin-myosin filament sliding (GO:0033275)7.47587794
3myofibril assembly (GO:0030239)6.48691553
4actin-mediated cell contraction (GO:0070252)6.32708134
5regulation of relaxation of muscle (GO:1901077)6.24330679
6cardiac myofibril assembly (GO:0055003)6.15622321
7sarcoplasmic reticulum calcium ion transport (GO:0070296)6.11704657
8sarcomere organization (GO:0045214)6.10556644
9nuclear pore complex assembly (GO:0051292)5.98952609
10nuclear pore organization (GO:0006999)5.82428436
11positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.36092400
12cardiac muscle hypertrophy (GO:0003300)5.33851705
13regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.27358720
14regulation of skeletal muscle contraction (GO:0014819)5.09360992
15striated muscle hypertrophy (GO:0014897)5.04234558
16actin filament-based movement (GO:0030048)4.88062769
17cardiac muscle contraction (GO:0060048)4.87837883
18regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.79745975
19cardiac muscle cell development (GO:0055013)4.78683606
20pore complex assembly (GO:0046931)4.76248550
21striated muscle contraction (GO:0006941)4.76005451
22IMP biosynthetic process (GO:0006188)4.74128525
23adult heart development (GO:0007512)4.64988959
24actomyosin structure organization (GO:0031032)4.53384078
25mitotic sister chromatid cohesion (GO:0007064)4.52086967
26regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.50704124
27cardiac cell development (GO:0055006)4.48932452
28kinetochore organization (GO:0051383)4.35192295
29cardiac muscle tissue morphogenesis (GO:0055008)4.34926846
30DNA unwinding involved in DNA replication (GO:0006268)4.32551696
31muscle hypertrophy (GO:0014896)4.29583599
32regulation of actin filament-based movement (GO:1903115)4.27641777
33regulation of histone H3-K9 methylation (GO:0051570)4.21088394
34DNA replication initiation (GO:0006270)4.16819765
35regulation of the force of heart contraction (GO:0002026)4.13134678
36skeletal muscle contraction (GO:0003009)4.10169966
37muscle tissue morphogenesis (GO:0060415)4.07453076
38regulation of cardioblast differentiation (GO:0051890)4.02890138
39mitotic nuclear envelope disassembly (GO:0007077)4.02568839
40IMP metabolic process (GO:0046040)4.00694118
41negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.94434847
42DNA replication-dependent nucleosome assembly (GO:0006335)3.92038788
43DNA replication-dependent nucleosome organization (GO:0034723)3.92038788
44protein localization to kinetochore (GO:0034501)3.91670921
45cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.83358957
46regulation of helicase activity (GO:0051095)3.83186162
47DNA geometric change (GO:0032392)3.82427324
48DNA duplex unwinding (GO:0032508)3.81784925
49meiotic chromosome segregation (GO:0045132)3.81782744
50pre-miRNA processing (GO:0031054)3.81045894
51kinetochore assembly (GO:0051382)3.75099667
52regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.74626068
53chromatin remodeling at centromere (GO:0031055)3.74215634
54folic acid-containing compound biosynthetic process (GO:0009396)3.72337333
55membrane disassembly (GO:0030397)3.71584874
56nuclear envelope disassembly (GO:0051081)3.71584874
57relaxation of cardiac muscle (GO:0055119)3.68647266
58protein K6-linked ubiquitination (GO:0085020)3.66603705
59CENP-A containing nucleosome assembly (GO:0034080)3.62862598
60negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.61408009
61cardiac chamber formation (GO:0003207)3.61283162
62DNA strand elongation involved in DNA replication (GO:0006271)3.58547870
63negative regulation of potassium ion transmembrane transport (GO:1901380)3.57165488
64mitotic metaphase plate congression (GO:0007080)3.56395926
65DNA strand renaturation (GO:0000733)3.55851658
66nucleobase biosynthetic process (GO:0046112)3.54088010
67cell communication by electrical coupling (GO:0010644)3.47984221
68DNA strand elongation (GO:0022616)3.46762482
69metaphase plate congression (GO:0051310)3.46575663
70microtubule depolymerization (GO:0007019)3.46006907
71bone trabecula formation (GO:0060346)3.42153999
72regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.41534197
73DNA replication checkpoint (GO:0000076)3.40643458
74mitotic sister chromatid segregation (GO:0000070)3.39609025
75DNA replication-independent nucleosome organization (GO:0034724)3.39537204
76DNA replication-independent nucleosome assembly (GO:0006336)3.39537204
77sister chromatid segregation (GO:0000819)3.38369285
78regulation of DNA endoreduplication (GO:0032875)3.36246011
79regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.35521548
80positive regulation of chromosome segregation (GO:0051984)3.34509294
81regulation of skeletal muscle cell differentiation (GO:2001014)3.34219311
82chromatin assembly (GO:0031497)3.33356977
83regulation of RNA export from nucleus (GO:0046831)3.33280128
84response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.32814727
85protein localization to chromosome, centromeric region (GO:0071459)3.32560161
86telomere maintenance via semi-conservative replication (GO:0032201)3.32275644
87positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.32226173
88regulation of gene silencing by RNA (GO:0060966)3.32006177
89regulation of posttranscriptional gene silencing (GO:0060147)3.32006177
90regulation of gene silencing by miRNA (GO:0060964)3.32006177
91mitotic chromosome condensation (GO:0007076)3.30323150
92heterochromatin organization (GO:0070828)3.29770737
93cardiac muscle hypertrophy in response to stress (GO:0014898)3.29505318
94muscle hypertrophy in response to stress (GO:0003299)3.29505318
95cardiac muscle adaptation (GO:0014887)3.29505318
96negative regulation of histone methylation (GO:0031061)3.29232697
97mitotic recombination (GO:0006312)3.26757446
98positive regulation of histone H3-K4 methylation (GO:0051571)3.25981850
99histone exchange (GO:0043486)3.23708851
100purine nucleobase biosynthetic process (GO:0009113)3.23686189
101mismatch repair (GO:0006298)3.23624955
102negative regulation of DNA-dependent DNA replication (GO:2000104)3.22961357
103ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.20308548
104somatic diversification of immune receptors via somatic mutation (GO:0002566)3.20152480
105somatic hypermutation of immunoglobulin genes (GO:0016446)3.20152480
106striated muscle cell development (GO:0055002)3.17133835
107regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.17073126
108ribosome assembly (GO:0042255)3.17024720
109sequestering of extracellular ligand from receptor (GO:0035581)3.16897104
110chromatin assembly or disassembly (GO:0006333)3.16067609
111negative regulation of DNA repair (GO:0045738)3.15692394
112carnitine shuttle (GO:0006853)3.15249553
113paraxial mesoderm development (GO:0048339)3.12943576
114nucleotide-excision repair, DNA gap filling (GO:0006297)3.12808828
115muscle fiber development (GO:0048747)3.11708479
116muscle contraction (GO:0006936)3.11706273
117regulation of centrosome cycle (GO:0046605)3.10795225
118telomere maintenance via recombination (GO:0000722)3.10690626
119regulation of sarcomere organization (GO:0060297)3.09408293
120bundle of His cell to Purkinje myocyte communication (GO:0086069)3.09086771
121regulation of spindle organization (GO:0090224)3.08500596
122response to caffeine (GO:0031000)3.05969210
123positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.05695540
124positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.05695540
125positive regulation of mitotic sister chromatid separation (GO:1901970)3.05695540
126dosage compensation (GO:0007549)3.05582405
127regulation of transforming growth factor beta2 production (GO:0032909)3.05474108
128regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.03629556
129DNA conformation change (GO:0071103)3.03581560
130regulation of nucleobase-containing compound transport (GO:0032239)3.03575897
131negative regulation of myotube differentiation (GO:0010832)3.03132801
132establishment of chromosome localization (GO:0051303)3.02973925
133regulation of nuclear cell cycle DNA replication (GO:0033262)3.01635599
134striated muscle adaptation (GO:0014888)3.01351977
135spindle checkpoint (GO:0031577)3.01205442
136ncRNA catabolic process (GO:0034661)3.00599929
137regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.00565119
138regulation of striated muscle contraction (GO:0006942)2.99521533
139positive regulation of cardiac muscle cell proliferation (GO:0060045)2.98176545
140translesion synthesis (GO:0019985)2.97522400
141response to muscle activity (GO:0014850)2.96994659
142atrial septum morphogenesis (GO:0060413)2.96855534
143regulation of centriole replication (GO:0046599)2.96847889
144monoubiquitinated protein deubiquitination (GO:0035520)2.96755706
145regulation of mitotic spindle organization (GO:0060236)2.96582641
146maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.96461362
147response to inactivity (GO:0014854)2.94161280
148regulation of glucocorticoid metabolic process (GO:0031943)2.94118746
149positive regulation of histone methylation (GO:0031062)2.93781014
150relaxation of muscle (GO:0090075)2.92255659
151determination of adult lifespan (GO:0008340)2.91192188
152regulation of chromosome segregation (GO:0051983)2.90165959
153regulation of gene silencing (GO:0060968)2.90039491
154mitotic spindle checkpoint (GO:0071174)2.88718723
155regulation of mitotic metaphase/anaphase transition (GO:0030071)2.88438958
156attachment of spindle microtubules to kinetochore (GO:0008608)2.87909488
157positive regulation of cardiac muscle cell differentiation (GO:2000727)2.85783029
158telomere maintenance via telomere lengthening (GO:0010833)2.85328484
159negative regulation of chromosome segregation (GO:0051985)2.85179007
160muscle system process (GO:0003012)2.84797827
161negative regulation of striated muscle cell apoptotic process (GO:0010664)2.84788808
162DNA double-strand break processing (GO:0000729)2.83834664
163ribosome biogenesis (GO:0042254)2.83543879
164spindle assembly checkpoint (GO:0071173)2.82349570
165DNA synthesis involved in DNA repair (GO:0000731)2.82340125
166sister chromatid cohesion (GO:0007062)2.81885476
167regulation of cell communication by electrical coupling (GO:0010649)2.81304916
168regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.80855364
169negative regulation of mitotic sister chromatid separation (GO:2000816)2.80726187
170negative regulation of mitotic sister chromatid segregation (GO:0033048)2.80726187
171negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.80726187
172negative regulation of sister chromatid segregation (GO:0033046)2.80726187
173positive regulation of cardiac muscle tissue growth (GO:0055023)2.80691796
174muscle cell development (GO:0055001)2.80197361
175endocardial cushion morphogenesis (GO:0003203)2.79555819
176NLS-bearing protein import into nucleus (GO:0006607)2.77911436
177positive regulation of cardiac muscle tissue development (GO:0055025)2.75526763
178regulation of cardiac muscle cell contraction (GO:0086004)2.74595944
179cartilage morphogenesis (GO:0060536)2.74356606
180regulation of myoblast differentiation (GO:0045661)2.70968706
181ventricular cardiac muscle cell action potential (GO:0086005)2.70050740
182skeletal muscle adaptation (GO:0043501)2.69277735
183regulation of acyl-CoA biosynthetic process (GO:0050812)2.69208129
184negative regulation of striated muscle cell differentiation (GO:0051154)2.68913321
185regulation of NFAT protein import into nucleus (GO:0051532)2.68141181
186regulation of ATPase activity (GO:0043462)2.67100562
187regulation of ATP catabolic process (GO:1903289)2.67100562
188negative regulation of skeletal muscle tissue development (GO:0048642)2.64925572
189regulation of cofactor metabolic process (GO:0051193)2.64820919
190regulation of coenzyme metabolic process (GO:0051196)2.64820919

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.98361408
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.79731741
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.97410509
4GATA1_22025678_ChIP-Seq_K562_Human3.77500204
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.34246837
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.21250291
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.15311596
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.84046514
9EP300_21415370_ChIP-Seq_HL-1_Mouse2.76787733
10WT1_19549856_ChIP-ChIP_CCG9911_Human2.75871521
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.59795913
12* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.48995855
13AR_21909140_ChIP-Seq_LNCAP_Human2.46533979
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.42238721
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.38446811
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.34901676
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.34002338
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.16930218
19MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.16854864
20TP63_19390658_ChIP-ChIP_HaCaT_Human2.14054008
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08771177
22E2F7_22180533_ChIP-Seq_HELA_Human12.1793886
23RBPJ_22232070_ChIP-Seq_NCS_Mouse1.91899872
24RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89222025
25* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89149721
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.87242420
27TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.86993521
28* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.84648504
29CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.82591525
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.80890751
31SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.80175038
32MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.80111078
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79110640
34GATA4_21415370_ChIP-Seq_HL-1_Mouse1.78626181
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.78430757
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77840466
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74468857
38KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.71502640
39KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.71502640
40KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.71502640
41* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.70630427
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.69705379
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67633611
44* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64576207
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63728232
46EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.63609995
47ELK1_19687146_ChIP-ChIP_HELA_Human1.61092316
48TBX20_22328084_ChIP-Seq_HEART_Mouse1.59925757
49TBX20_22080862_ChIP-Seq_HEART_Mouse1.59925757
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58708381
51PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.55148438
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.54881772
53VDR_23849224_ChIP-Seq_CD4+_Human1.49823756
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47598106
55SOX2_18555785_ChIP-Seq_MESCs_Mouse1.46220589
56ISL1_27105846_Chip-Seq_CPCs_Mouse1.45616015
57CREB1_15753290_ChIP-ChIP_HEK293T_Human1.44598050
58TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.44541632
59KDM5A_27292631_Chip-Seq_BREAST_Human1.44241417
60FOXP3_21729870_ChIP-Seq_TREG_Human1.43208250
61SALL4_18804426_ChIP-ChIP_XEN_Mouse1.42859336
62XRN2_22483619_ChIP-Seq_HELA_Human1.42252096
63NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.39090065
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38671256
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36815430
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.36719047
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34007218
68MYC_22102868_ChIP-Seq_BL_Human1.29579733
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28540568
70FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.27503499
71* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26498244
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25734338
73GABP_17652178_ChIP-ChIP_JURKAT_Human1.24664384
74TCF3_18692474_ChIP-Seq_MESCs_Mouse1.24043766
75CIITA_25753668_ChIP-Seq_RAJI_Human1.21302051
76CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20404655
77ETS1_20019798_ChIP-Seq_JURKAT_Human1.20128988
78* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19997834
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18166179
80TTF2_22483619_ChIP-Seq_HELA_Human1.15127410
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14188671
82FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13888129
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13524319
84SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13249230
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12478390
86EWS_26573619_Chip-Seq_HEK293_Human1.11484368
87* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11183906
88ZNF263_19887448_ChIP-Seq_K562_Human1.10462312
89DCP1A_22483619_ChIP-Seq_HELA_Human1.09945120
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08124388
91HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.07310566
92SOX9_26525672_Chip-Seq_HEART_Mouse1.07135175
93DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06615778
94SMAD3_21741376_ChIP-Seq_HESCs_Human1.06152869
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05728909
96TAF15_26573619_Chip-Seq_HEK293_Human1.04714367
97SMAD_19615063_ChIP-ChIP_OVARY_Human1.04335959
98* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.03716105
99TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02630062
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.02226580
101ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02057807
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01025732
103YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99431053
104KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99385479
105FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98689522
106SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98352231
107NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.97098788
108SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97005981
109CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96906399
110FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.95577252
111ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94894521
112ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94727088
113HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94100596
114CLOCK_20551151_ChIP-Seq_293T_Human0.93518018
115CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93374707
116NANOG_21062744_ChIP-ChIP_HESCs_Human0.92461710
117* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92385218
118IRF1_19129219_ChIP-ChIP_H3396_Human0.92179363
119SOX2_16153702_ChIP-ChIP_HESCs_Human0.91312182
120E2F1_18555785_Chip-Seq_ESCs_Mouse0.91213690
121ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.90566499
122SMAD4_21799915_ChIP-Seq_A2780_Human0.90054008
123DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89840577
124ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89724283
125NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88515276
126ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87944982
127* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87513941
128* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87280881
129GBX2_23144817_ChIP-Seq_PC3_Human0.86201297
130SMAD3_21741376_ChIP-Seq_EPCs_Human0.86185331
131ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86040799
132GABP_19822575_ChIP-Seq_HepG2_Human0.85801365
133SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.85698090
134TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84784616
135FUS_26573619_Chip-Seq_HEK293_Human0.84418069
136ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84303249
137* STAT3_23295773_ChIP-Seq_U87_Human0.83610438
138NANOG_16153702_ChIP-ChIP_HESCs_Human0.83019360
139STAT3_1855785_ChIP-Seq_MESCs_Mouse0.82853227
140PCGF2_27294783_Chip-Seq_NPCs_Mouse0.82819007
141ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.82815705
142ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.82617194
143* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82289033
144TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.81622925
145MYC_18940864_ChIP-ChIP_HL60_Human0.81288701
146FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.80682899
147SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.80187756
148HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.80058148
149THAP11_20581084_ChIP-Seq_MESCs_Mouse0.79376922
150TFEB_21752829_ChIP-Seq_HELA_Human0.78748988
151PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.78712823
152P300_19829295_ChIP-Seq_ESCs_Human0.78351613
153CHD1_26751641_Chip-Seq_LNCaP_Human0.78213071
154CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.78107755
155NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.77709794
156FLI1_27457419_Chip-Seq_LIVER_Mouse0.76988727
157SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.76923683
158KLF4_18555785_ChIP-Seq_MESCs_Mouse0.76472065
159SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.75586464
160ESR1_15608294_ChIP-ChIP_MCF-7_Human0.74824268
161CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.73291595

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio5.71495130
2MP0008057_abnormal_DNA_replication5.31075258
3MP0010094_abnormal_chromosome_stability4.66759513
4MP0004084_abnormal_cardiac_muscle4.42234161
5MP0003111_abnormal_nucleus_morphology4.31175672
6MP0000751_myopathy3.94459923
7MP0004036_abnormal_muscle_relaxation3.89080550
8MP0000749_muscle_degeneration3.66854327
9MP0003693_abnormal_embryo_hatching3.54923614
10MP0003646_muscle_fatigue3.41119583
11MP0008058_abnormal_DNA_repair3.34348550
12MP0003077_abnormal_cell_cycle3.33345773
13MP0004957_abnormal_blastocyst_morpholog3.28158002
14MP0004215_abnormal_myocardial_fiber2.83446092
15MP0005330_cardiomyopathy2.70319651
16MP0004087_abnormal_muscle_fiber2.69127809
17MP0000747_muscle_weakness2.68746826
18MP0004510_myositis2.58028013
19MP0002106_abnormal_muscle_physiology2.52929532
20MP0003123_paternal_imprinting2.42905466
21MP0008877_abnormal_DNA_methylation2.35583809
22MP0008007_abnormal_cellular_replicative2.34061022
23MP0010307_abnormal_tumor_latency2.31615807
24MP0005620_abnormal_muscle_contractility2.19769005
25MP0003121_genomic_imprinting2.19433711
26MP0003950_abnormal_plasma_membrane2.18940665
27MP0002396_abnormal_hematopoietic_system2.17916213
28MP0010630_abnormal_cardiac_muscle2.14637563
29MP0002269_muscular_atrophy2.12914792
30MP0001661_extended_life_span2.10449101
31MP0002972_abnormal_cardiac_muscle2.08159628
32MP0002837_dystrophic_cardiac_calcinosis2.07809483
33MP0010352_gastrointestinal_tract_polyps2.06842265
34MP0000759_abnormal_skeletal_muscle2.06759273
35MP0008775_abnormal_heart_ventricle2.05647154
36MP0005369_muscle_phenotype2.05624366
37MP0000350_abnormal_cell_proliferation2.05296956
38MP0008932_abnormal_embryonic_tissue2.04410894
39MP0004233_abnormal_muscle_weight1.95877071
40MP0001730_embryonic_growth_arrest1.95741653
41MP0001672_abnormal_embryogenesis/_devel1.93209988
42MP0005380_embryogenesis_phenotype1.93209988
43MP0002127_abnormal_cardiovascular_syste1.92555437
44MP0003890_abnormal_embryonic-extraembry1.90056682
45MP0000750_abnormal_muscle_regeneration1.88932050
46MP0003221_abnormal_cardiomyocyte_apopto1.79987419
47MP0003786_premature_aging1.78497013
48MP0004197_abnormal_fetal_growth/weight/1.72687119
49MP0005076_abnormal_cell_differentiation1.72381002
50MP0003984_embryonic_growth_retardation1.72069609
51MP0002088_abnormal_embryonic_growth/wei1.70432383
52MP0002084_abnormal_developmental_patter1.68288623
53MP0002085_abnormal_embryonic_tissue1.59699185
54MP0001293_anophthalmia1.56930082
55MP0002086_abnormal_extraembryonic_tissu1.56836097
56MP0001697_abnormal_embryo_size1.56341997
57MP0004130_abnormal_muscle_cell1.56334770
58MP0005451_abnormal_body_composition1.52968569
59MP0002822_catalepsy1.51292997
60MP0006292_abnormal_olfactory_placode1.48782414
61MP0002009_preneoplasia1.46656618
62MP0004808_abnormal_hematopoietic_stem1.46325042
63MP0003941_abnormal_skin_development1.45971856
64MP0004185_abnormal_adipocyte_glucose1.41962784
65MP0006138_congestive_heart_failure1.40715723
66MP0002210_abnormal_sex_determination1.38297194
67MP0003567_abnormal_fetal_cardiomyocyte1.37681562
68MP0005385_cardiovascular_system_phenoty1.37392760
69MP0001544_abnormal_cardiovascular_syste1.37392760
70MP0003937_abnormal_limbs/digits/tail_de1.33704519
71MP0004484_altered_response_of1.31477481
72MP0002080_prenatal_lethality1.29407606
73MP0002332_abnormal_exercise_endurance1.29307186
74MP0000313_abnormal_cell_death1.28216978
75MP0000490_abnormal_crypts_of1.26813912
76MP0002108_abnormal_muscle_morphology1.23556557
77MP0009333_abnormal_splenocyte_physiolog1.19798211
78MP0003763_abnormal_thymus_physiology1.15470718
79MP0003705_abnormal_hypodermis_morpholog1.15455564
80MP0001929_abnormal_gametogenesis1.14931135
81MP0001145_abnormal_male_reproductive1.13709838
82MP0003137_abnormal_impulse_conducting1.13404216
83MP0000703_abnormal_thymus_morphology1.13376276
84MP0004085_abnormal_heartbeat1.11962689
85MP0001286_abnormal_eye_development1.11389748
86MP0000432_abnormal_head_morphology1.10689603
87MP0000427_abnormal_hair_cycle1.09754162
88MP0002019_abnormal_tumor_incidence1.09639557
89MP0010030_abnormal_orbit_morphology1.09336865
90MP0000566_synostosis1.08400927
91MP0009703_decreased_birth_body1.01663614
92MP0000266_abnormal_heart_morphology1.01576171
93MP0009697_abnormal_copulation1.01548074
94MP0002697_abnormal_eye_size1.00698796
95MP0003787_abnormal_imprinting0.99301123
96MP0002877_abnormal_melanocyte_morpholog0.99220500
97MP0002398_abnormal_bone_marrow0.93993807
98MP0000653_abnormal_sex_gland0.92910640
99MP0002092_abnormal_eye_morphology0.90723196
100MP0001915_intracranial_hemorrhage0.90720034
101MP0002111_abnormal_tail_morphology0.90010560
102MP0000462_abnormal_digestive_system0.87915857
103MP0002160_abnormal_reproductive_system0.87028351
104MP0000733_abnormal_muscle_development0.85716291
105MP0003935_abnormal_craniofacial_develop0.84780988
106MP0002722_abnormal_immune_system0.83704907
107MP0000428_abnormal_craniofacial_morphol0.83567681
108MP0009672_abnormal_birth_weight0.83344074
109MP0003045_fibrosis0.82479272
110MP0001188_hyperpigmentation0.81700786
111MP0001119_abnormal_female_reproductive0.81068595
112MP0000689_abnormal_spleen_morphology0.80132522
113MP0004272_abnormal_basement_membrane0.79847151
114MP0000516_abnormal_urinary_system0.79106994
115MP0005367_renal/urinary_system_phenotyp0.79106994
116MP0000383_abnormal_hair_follicle0.79006576
117MP0005266_abnormal_metabolism0.78415562
118MP0003385_abnormal_body_wall0.77550522
119MP0002925_abnormal_cardiovascular_devel0.77351646
120MP0001299_abnormal_eye_distance/0.76325021
121MP0000569_abnormal_digit_pigmentation0.75710229
122MP0002102_abnormal_ear_morphology0.75333069
123MP0005623_abnormal_meninges_morphology0.74318798
124MP0005187_abnormal_penis_morphology0.73494828
125MP0005248_abnormal_Harderian_gland0.73410073
126MP0003755_abnormal_palate_morphology0.73384743
127MP0003566_abnormal_cell_adhesion0.73270241
128MP0005666_abnormal_adipose_tissue0.72706374
129MP0000579_abnormal_nail_morphology0.72617781
130MP0002128_abnormal_blood_circulation0.72603133
131MP0003119_abnormal_digestive_system0.72442775
132MP0003861_abnormal_nervous_system0.72292393
133MP0002075_abnormal_coat/hair_pigmentati0.71896678
134MP0000762_abnormal_tongue_morphology0.70820779
135MP0003718_maternal_effect0.70795552
136MP0002006_tumorigenesis0.70777645
137MP0010234_abnormal_vibrissa_follicle0.70397984
138MP0003698_abnormal_male_reproductive0.70265113
139MP0005621_abnormal_cell_physiology0.70247345
140MP0009250_abnormal_appendicular_skeleto0.69972865
141MP0003828_pulmonary_edema0.69875715
142MP0005389_reproductive_system_phenotype0.68914206
143MP0002095_abnormal_skin_pigmentation0.68581710
144MP0000537_abnormal_urethra_morphology0.67941839
145MP0005384_cellular_phenotype0.67396333
146MP0001545_abnormal_hematopoietic_system0.66509903
147MP0005397_hematopoietic_system_phenotyp0.66509903
148MP0001186_pigmentation_phenotype0.64817728
149MP0000015_abnormal_ear_pigmentation0.63197219
150MP0004133_heterotaxia0.60846147
151MP0002938_white_spotting0.59758547
152MP0002429_abnormal_blood_cell0.59097898
153MP0001784_abnormal_fluid_regulation0.58849707
154MP0002166_altered_tumor_susceptibility0.58532291
155MP0002109_abnormal_limb_morphology0.55755866
156MP0000049_abnormal_middle_ear0.55197924

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)8.05013433
2Muscle fiber inclusion bodies (HP:0100299)7.96053274
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.94813353
4Chromosomal breakage induced by crosslinking agents (HP:0003221)5.80019032
5Abnormality of the calf musculature (HP:0001430)5.76700540
6Chromsome breakage (HP:0040012)5.74792494
7Type 1 muscle fiber predominance (HP:0003803)5.70983717
8Exercise-induced muscle cramps (HP:0003710)5.63350803
9Muscle hypertrophy of the lower extremities (HP:0008968)5.48785906
10Calf muscle hypertrophy (HP:0008981)5.22437710
11Ventricular tachycardia (HP:0004756)4.99115664
12Exercise-induced myalgia (HP:0003738)4.87560780
13Abnormality of the left ventricular outflow tract (HP:0011103)4.86337734
14Subaortic stenosis (HP:0001682)4.86337734
15Sudden death (HP:0001699)4.74337616
16Bundle branch block (HP:0011710)4.65887547
17Centrally nucleated skeletal muscle fibers (HP:0003687)4.50201702
18EMG: myopathic abnormalities (HP:0003458)4.35420533
19Rimmed vacuoles (HP:0003805)4.24959058
20Abnormality of chromosome stability (HP:0003220)4.04557885
21Abnormality of the preputium (HP:0100587)3.63915659
22Distal arthrogryposis (HP:0005684)3.62782338
23Hyporeflexia of lower limbs (HP:0002600)3.62243598
24Aplasia/Hypoplasia of the uvula (HP:0010293)3.61995008
25Birth length less than 3rd percentile (HP:0003561)3.60400030
26Neck muscle weakness (HP:0000467)3.58308290
27Muscle fiber splitting (HP:0003555)3.56269338
28Right ventricular cardiomyopathy (HP:0011663)3.49088533
29Meckel diverticulum (HP:0002245)3.46807737
30Myopathic facies (HP:0002058)3.37073618
31Hip contracture (HP:0003273)3.29660814
32Lipoatrophy (HP:0100578)3.29062549
33Abnormality of the ileum (HP:0001549)3.28224265
34Difficulty running (HP:0009046)3.25939681
35Volvulus (HP:0002580)3.21333402
36Dilated cardiomyopathy (HP:0001644)3.12808726
37Urethral obstruction (HP:0000796)3.11601190
38Ectopic kidney (HP:0000086)3.03504372
39Medulloblastoma (HP:0002885)3.03063833
40Impulsivity (HP:0100710)3.01704591
41Small intestinal stenosis (HP:0012848)2.98302985
42Duodenal stenosis (HP:0100867)2.98302985
43Rhabdomyolysis (HP:0003201)2.95613853
44Ependymoma (HP:0002888)2.93965952
45Selective tooth agenesis (HP:0001592)2.92031010
46Absent radius (HP:0003974)2.90677931
47Myelodysplasia (HP:0002863)2.87402108
48Myoglobinuria (HP:0002913)2.84377922
49Areflexia of lower limbs (HP:0002522)2.81786414
50Duplicated collecting system (HP:0000081)2.75666902
51Abnormality of the labia minora (HP:0012880)2.72288488
52Abnormality of skeletal muscle fiber size (HP:0012084)2.69903474
53Increased connective tissue (HP:0009025)2.68108331
54Absent forearm bone (HP:0003953)2.66839370
55Aplasia involving forearm bones (HP:0009822)2.66839370
56Progressive muscle weakness (HP:0003323)2.60537485
57Heart block (HP:0012722)2.60451725
58EMG: neuropathic changes (HP:0003445)2.58434710
59Abnormality of the duodenum (HP:0002246)2.54275216
60Clubbing of toes (HP:0100760)2.54136315
61Calcaneovalgus deformity (HP:0001848)2.51761318
62Degeneration of anterior horn cells (HP:0002398)2.49306513
63Abnormality of the anterior horn cell (HP:0006802)2.49306513
64Atrial fibrillation (HP:0005110)2.48941748
65Nephroblastoma (Wilms tumor) (HP:0002667)2.48259711
66Abnormality of DNA repair (HP:0003254)2.47889557
67Sloping forehead (HP:0000340)2.46015669
68Abnormality of the carotid arteries (HP:0005344)2.45965694
69Limited hip movement (HP:0008800)2.45276528
70Abnormal number of incisors (HP:0011064)2.43003655
71Agnosia (HP:0010524)2.40770645
72Abnormal atrioventricular conduction (HP:0005150)2.39386944
73Abnormality of the renal collecting system (HP:0004742)2.37881388
74Round ear (HP:0100830)2.37117684
75Embryonal renal neoplasm (HP:0011794)2.31749966
76Deviation of the thumb (HP:0009603)2.29645506
77Patellar aplasia (HP:0006443)2.27122347
78Metatarsus adductus (HP:0001840)2.25497831
79Proximal placement of thumb (HP:0009623)2.25294035
80Generalized muscle weakness (HP:0003324)2.24936412
81Asymmetric septal hypertrophy (HP:0001670)2.24149377
82Rhabdomyosarcoma (HP:0002859)2.23765217
83Bone marrow hypocellularity (HP:0005528)2.23659240
84Abnormality of the fingertips (HP:0001211)2.23648956
85Mildly elevated creatine phosphokinase (HP:0008180)2.22833758
86Reticulocytopenia (HP:0001896)2.21538708
87Increased variability in muscle fiber diameter (HP:0003557)2.21386974
88Distal lower limb muscle weakness (HP:0009053)2.20083720
89Frequent falls (HP:0002359)2.19702016
90Anal stenosis (HP:0002025)2.18347154
91Muscular dystrophy (HP:0003560)2.17521241
92Glioma (HP:0009733)2.17151883
93Breast hypoplasia (HP:0003187)2.16683214
94Absent phalangeal crease (HP:0006109)2.16433283
95Short thumb (HP:0009778)2.15777006
96Ulnar deviation of the wrist (HP:0003049)2.15105456
97Astrocytoma (HP:0009592)2.14029215
98Abnormality of the astrocytes (HP:0100707)2.14029215
99Cafe-au-lait spot (HP:0000957)2.12610495
100Neoplasm of the oral cavity (HP:0100649)2.12608551
101Ulnar deviation of finger (HP:0009465)2.11850638
102Deformed tarsal bones (HP:0008119)2.11555723
103Dysmetric saccades (HP:0000641)2.11415551
104Muscle stiffness (HP:0003552)2.10862482
105Primary atrial arrhythmia (HP:0001692)2.10002239
106High pitched voice (HP:0001620)2.06512144
107Aplasia/Hypoplasia of the patella (HP:0006498)2.04668277
108Prominent nose (HP:0000448)2.03411704
109Aplasia/hypoplasia of the humerus (HP:0006507)2.02010869
110Papillary thyroid carcinoma (HP:0002895)2.00249445
111Absent thumb (HP:0009777)1.98871202
112Hypoplasia of the capital femoral epiphysis (HP:0003090)1.98755046
113Short humerus (HP:0005792)1.98475108
114Colon cancer (HP:0003003)1.98405776
115Deep philtrum (HP:0002002)1.97981702
116Abnormal finger flexion creases (HP:0006143)1.97698204
117Supraventricular tachycardia (HP:0004755)1.97577710
118Distal lower limb amyotrophy (HP:0008944)1.97506876
119Pelvic girdle muscle weakness (HP:0003749)1.96452815
120Squamous cell carcinoma (HP:0002860)1.96028412
121Amaurosis fugax (HP:0100576)1.95404240
122Ventricular arrhythmia (HP:0004308)1.95071175
123Increased nuchal translucency (HP:0010880)1.94832356
124Triphalangeal thumb (HP:0001199)1.94758558
125Abnormality of the calcaneus (HP:0008364)1.94748082
126Acute myeloid leukemia (HP:0004808)1.93498150
127Supernumerary spleens (HP:0009799)1.92739820
128Supraventricular arrhythmia (HP:0005115)1.91908700
129Malignant hyperthermia (HP:0002047)1.91300126
130Overlapping toe (HP:0001845)1.89440567
131Bicuspid aortic valve (HP:0001647)1.87605545
132Long eyelashes (HP:0000527)1.85493089
133Hypoplastic labia majora (HP:0000059)1.85104085
134Abnormality of the musculature of the pelvis (HP:0001469)1.84155420
135Abnormality of the hip-girdle musculature (HP:0001445)1.84155420
136Shoulder girdle muscle weakness (HP:0003547)1.83819614
137Skull defect (HP:0001362)1.82503448
138Fibular aplasia (HP:0002990)1.82411157
139Sparse lateral eyebrow (HP:0005338)1.82102719
140Lymphoma (HP:0002665)1.81545498
141Long clavicles (HP:0000890)1.80829829
142Tracheoesophageal fistula (HP:0002575)1.78849703
143Biliary tract neoplasm (HP:0100574)1.77981927
144Abnormal lung lobation (HP:0002101)1.77945189
145Hyperkalemia (HP:0002153)1.77803065
146Progressive external ophthalmoplegia (HP:0000590)1.77761489
14711 pairs of ribs (HP:0000878)1.77567376
148Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.77277025
149Intestinal atresia (HP:0011100)1.77104803
150Proximal amyotrophy (HP:0007126)1.76589665
151Entropion (HP:0000621)1.75347421
152Gowers sign (HP:0003391)1.73199823
153Myotonia (HP:0002486)1.72368978
154Facial hemangioma (HP:0000329)1.70819469
155Diaphragmatic weakness (HP:0009113)1.70515333
156Breast aplasia (HP:0100783)1.70220973
157Duplication of thumb phalanx (HP:0009942)1.69865099
158Neoplasm of the pancreas (HP:0002894)1.67911068
159Scapular winging (HP:0003691)1.67761281
160Ureteral duplication (HP:0000073)1.67491770
161Poikiloderma (HP:0001029)1.67328142
162Syncope (HP:0001279)1.66750923
163Premature graying of hair (HP:0002216)1.66616677
164Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.65931170
165Short 4th metacarpal (HP:0010044)1.65931170
166Palpitations (HP:0001962)1.65781484
167Basal cell carcinoma (HP:0002671)1.65637672
168Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.65400629
169Absent epiphyses (HP:0010577)1.65400629
170Arteriovenous malformation (HP:0100026)1.65295455
171Malignant gastrointestinal tract tumors (HP:0006749)1.64579250
172Gastrointestinal carcinoma (HP:0002672)1.64579250
173Toxemia of pregnancy (HP:0100603)1.64508833
174Freckling (HP:0001480)1.63592514
175Aplasia/Hypoplasia of the earlobes (HP:0009906)1.63425876
176Leukopenia (HP:0001882)1.63206571
177Rough bone trabeculation (HP:0100670)1.63014369
178Abnormality of the labia majora (HP:0012881)1.62711529
179Abnormality of the incisor (HP:0000676)1.62004420
180Lower limb amyotrophy (HP:0007210)1.61927052
181Neoplasm of striated muscle (HP:0009728)1.61534581
182Abnormality of the ischium (HP:0003174)1.60489961
183Cystic hygroma (HP:0000476)1.59625591
184Childhood onset (HP:0011463)1.57055605
185Atrioventricular block (HP:0001678)1.54174637
186Abnormality of the salivary glands (HP:0010286)1.52849348
187Abnormality of the shoulder girdle musculature (HP:0001435)1.52723861
188Mitral valve prolapse (HP:0001634)1.51801218
189Steppage gait (HP:0003376)1.49687724
190Abnormality of the foot musculature (HP:0001436)1.48968728
191Weak cry (HP:0001612)1.48366340
192Knee flexion contracture (HP:0006380)1.46553514
193Limb-girdle muscle atrophy (HP:0003797)1.45918238
194Spinal rigidity (HP:0003306)1.43851758
195Neoplasm of the small intestine (HP:0100833)1.42894791

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN9.62759296
2CDC74.45205207
3PKN24.16878344
4CDK123.69104485
5PRPF4B3.63820971
6WEE13.12869485
7ZAK2.93316786
8SRPK12.78884755
9TTK2.59889517
10MKNK22.36024225
11PHKG22.28288681
12PHKG12.28288681
13DMPK2.23074110
14NEK22.22927067
15BRD42.18730907
16BUB12.16901200
17MKNK12.13945268
18PLK32.13684957
19TSSK62.02000227
20YES12.01642778
21ATR1.94404937
22EIF2AK11.82547669
23PLK41.78694264
24PLK11.75469904
25TLK11.74734220
26AKT31.66610132
27STK101.64036602
28SCYL21.63486415
29CHEK21.57994939
30CDK71.52280405
31PASK1.51843510
32BRSK21.50385960
33CHEK11.49744364
34ATM1.44498849
35AURKB1.42044909
36EEF2K1.35928566
37STK41.34638431
38EPHA21.32936680
39MAP3K71.31950514
40PIM11.31413084
41RPS6KB21.30511525
42PIK3CG1.27279655
43PNCK1.26930201
44EIF2AK31.25560968
45PBK1.24944490
46DYRK31.24520174
47CDK41.24238952
48NEK91.18145128
49LATS21.17545159
50VRK11.13261179
51MAP3K81.11260513
52MELK1.08347730
53STK31.04059391
54ALK1.02350143
55CDK61.01740054
56CDK21.01051962
57EIF2AK20.98528090
58STK240.97564190
59MAP2K30.96090823
60CDK10.90746124
61MAPK120.84769659
62ICK0.84431416
63TAF10.83015161
64TNIK0.81667434
65PRKAA20.76567520
66CSNK1D0.76016069
67MTOR0.73004312
68MAP3K100.72977630
69AURKA0.71977364
70MAP3K140.71334483
71CAMK40.69704492
72GRK70.68901971
73LATS10.68678901
74CDK80.68329473
75GSK3A0.68025887
76RPS6KA50.66357249
77PRKDC0.66319717
78CDK90.65945075
79CSNK1A1L0.65782528
80PDGFRA0.64115082
81NEK10.63755320
82TXK0.63469025
83MAPK140.62030199
84PRKAA10.61445610
85PIK3CA0.60994042
86CSNK2A20.60977752
87TRPM70.59974927
88MARK30.59913844
89MET0.58763355
90TGFBR10.56923912
91FLT30.54951921
92NLK0.54120084
93CHUK0.53899204
94CAMK1G0.53141982
95ACVR1B0.52505292
96SGK30.51855507
97NEK60.51341119
98GSK3B0.50371538
99AKT20.49893840
100KSR20.48554003
101WNK10.47741706
102SMG10.47034746
103RET0.46633610
104CSNK1E0.46303401
105FRK0.45196161
106BRSK10.45132398
107MAPK10.44980389
108RAF10.44279808
109MAPK100.43891189
110CSNK2A10.43751838
111RPS6KA40.43556306
112RPS6KB10.42529541
113JAK30.41843863
114CAMK10.41477767
115PDK20.40960246
116SGK20.39448973
117ERBB40.38933219
118AKT10.38867807
119CLK10.37685121
120MUSK0.36581531
121TTN0.34524648
122CDK30.32793436
123ERBB30.32751804
124PAK20.32391492
125CAMK1D0.32261298
126TRIB30.30789297
127MAP2K40.30350874
128MAPK80.30134389
129TEC0.29985202
130STK38L0.29208435
131CAMK2D0.28280690
132MST1R0.27986554
133KSR10.27500356
134MAP3K60.27218450
135NUAK10.26966608
136MAPK90.26910441
137MAP3K130.26798112
138FGFR10.26720487
139IKBKB0.26268646
140MAPK70.26246087
141DYRK20.25550506
142MAPK110.25485379
143CCNB10.24510129
144MAPKAPK20.24247639
145MAP4K10.23418584

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.95359294
2DNA replication_Homo sapiens_hsa030303.94223014
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.85424402
4Mismatch repair_Homo sapiens_hsa034303.81634410
5Dilated cardiomyopathy_Homo sapiens_hsa054143.58745806
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.34486386
7Fanconi anemia pathway_Homo sapiens_hsa034603.19478876
8One carbon pool by folate_Homo sapiens_hsa006703.14091789
9Homologous recombination_Homo sapiens_hsa034403.11453112
10RNA transport_Homo sapiens_hsa030132.91890956
11Cell cycle_Homo sapiens_hsa041102.80275583
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.60229704
13Non-homologous end-joining_Homo sapiens_hsa034502.59958640
14Spliceosome_Homo sapiens_hsa030402.58829108
15Nucleotide excision repair_Homo sapiens_hsa034202.47799889
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.42336221
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.40223389
18Base excision repair_Homo sapiens_hsa034102.36670427
19Systemic lupus erythematosus_Homo sapiens_hsa053222.24167035
20RNA polymerase_Homo sapiens_hsa030202.14624519
21RNA degradation_Homo sapiens_hsa030182.06639787
22mRNA surveillance pathway_Homo sapiens_hsa030152.00796251
23Cardiac muscle contraction_Homo sapiens_hsa042601.93889969
24Basal transcription factors_Homo sapiens_hsa030221.85571710
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.79146310
26p53 signaling pathway_Homo sapiens_hsa041151.68473191
27Vitamin B6 metabolism_Homo sapiens_hsa007501.61481660
28Pyrimidine metabolism_Homo sapiens_hsa002401.59165936
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55594152
30Insulin signaling pathway_Homo sapiens_hsa049101.52207443
31Viral carcinogenesis_Homo sapiens_hsa052031.49908467
32Carbon metabolism_Homo sapiens_hsa012001.44983698
33Propanoate metabolism_Homo sapiens_hsa006401.38237356
34Endometrial cancer_Homo sapiens_hsa052131.33490082
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.33421720
36Central carbon metabolism in cancer_Homo sapiens_hsa052301.33234185
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.29714238
38Herpes simplex infection_Homo sapiens_hsa051681.26865326
39Biosynthesis of amino acids_Homo sapiens_hsa012301.26460705
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.23025401
41MicroRNAs in cancer_Homo sapiens_hsa052061.22214935
42Glucagon signaling pathway_Homo sapiens_hsa049221.20247176
43Proteasome_Homo sapiens_hsa030501.16808546
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16448107
45Insulin resistance_Homo sapiens_hsa049311.15208549
46Pentose phosphate pathway_Homo sapiens_hsa000301.12956343
47NF-kappa B signaling pathway_Homo sapiens_hsa040641.11172334
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10473675
49Epstein-Barr virus infection_Homo sapiens_hsa051691.09589558
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06971095
51HTLV-I infection_Homo sapiens_hsa051661.06940642
52Pyruvate metabolism_Homo sapiens_hsa006201.06214669
53Antigen processing and presentation_Homo sapiens_hsa046121.02878178
54Non-small cell lung cancer_Homo sapiens_hsa052231.00366235
55Thyroid cancer_Homo sapiens_hsa052160.99207002
56Ribosome_Homo sapiens_hsa030100.98907706
57Focal adhesion_Homo sapiens_hsa045100.98601715
58Small cell lung cancer_Homo sapiens_hsa052220.98261639
59Purine metabolism_Homo sapiens_hsa002300.96878322
60Basal cell carcinoma_Homo sapiens_hsa052170.95430045
61AMPK signaling pathway_Homo sapiens_hsa041520.92237800
62Alcoholism_Homo sapiens_hsa050340.92116621
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87992365
64Calcium signaling pathway_Homo sapiens_hsa040200.85314769
65TGF-beta signaling pathway_Homo sapiens_hsa043500.84801343
66Allograft rejection_Homo sapiens_hsa053300.84643120
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82857993
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82505165
69Primary immunodeficiency_Homo sapiens_hsa053400.81727262
70Measles_Homo sapiens_hsa051620.80630211
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80055373
72Renal cell carcinoma_Homo sapiens_hsa052110.79370749
73Graft-versus-host disease_Homo sapiens_hsa053320.78765040
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.77270079
75Oxytocin signaling pathway_Homo sapiens_hsa049210.75377809
76Selenocompound metabolism_Homo sapiens_hsa004500.72429201
77Colorectal cancer_Homo sapiens_hsa052100.72159150
78Adherens junction_Homo sapiens_hsa045200.71395284
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70342899
80Glioma_Homo sapiens_hsa052140.69490174
81Prostate cancer_Homo sapiens_hsa052150.68068312
82Hippo signaling pathway_Homo sapiens_hsa043900.68047114
83Hematopoietic cell lineage_Homo sapiens_hsa046400.67977929
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66592073
85Chronic myeloid leukemia_Homo sapiens_hsa052200.65580035
86Autoimmune thyroid disease_Homo sapiens_hsa053200.64227517
87Notch signaling pathway_Homo sapiens_hsa043300.63647045
88Lysine degradation_Homo sapiens_hsa003100.63285427
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.63092189
90Type I diabetes mellitus_Homo sapiens_hsa049400.61330979
91Wnt signaling pathway_Homo sapiens_hsa043100.61155827
92Oocyte meiosis_Homo sapiens_hsa041140.60464445
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60372393
94Pathways in cancer_Homo sapiens_hsa052000.59979166
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59528111
96Arginine biosynthesis_Homo sapiens_hsa002200.57982682
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56055467
98Apoptosis_Homo sapiens_hsa042100.55856222
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55750328
100Legionellosis_Homo sapiens_hsa051340.52012747
101Starch and sucrose metabolism_Homo sapiens_hsa005000.51533040
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.49947946
103Hepatitis B_Homo sapiens_hsa051610.48976886
104Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47879534
105Asthma_Homo sapiens_hsa053100.47516599
106Viral myocarditis_Homo sapiens_hsa054160.46133493
107Jak-STAT signaling pathway_Homo sapiens_hsa046300.45581231
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45574113
109ErbB signaling pathway_Homo sapiens_hsa040120.43415883
110Arginine and proline metabolism_Homo sapiens_hsa003300.43382108
111Melanoma_Homo sapiens_hsa052180.42847496
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42800207
113T cell receptor signaling pathway_Homo sapiens_hsa046600.41014400
114Bladder cancer_Homo sapiens_hsa052190.40895781
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40532707
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.40528980
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40196325
118Renin-angiotensin system_Homo sapiens_hsa046140.38390294
119Influenza A_Homo sapiens_hsa051640.38382750
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38293601
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38028965
122Inositol phosphate metabolism_Homo sapiens_hsa005620.36440221
123Pancreatic cancer_Homo sapiens_hsa052120.34916883
124Circadian rhythm_Homo sapiens_hsa047100.33986171
125Acute myeloid leukemia_Homo sapiens_hsa052210.32488618
126Vitamin digestion and absorption_Homo sapiens_hsa049770.32001638
127FoxO signaling pathway_Homo sapiens_hsa040680.30445885
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30146323
129HIF-1 signaling pathway_Homo sapiens_hsa040660.28443329
130Hedgehog signaling pathway_Homo sapiens_hsa043400.28053110
131Proteoglycans in cancer_Homo sapiens_hsa052050.27920240
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25245322
133N-Glycan biosynthesis_Homo sapiens_hsa005100.25054652
134Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24020639
135ECM-receptor interaction_Homo sapiens_hsa045120.23485183
136Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23035605
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22186497
138Toxoplasmosis_Homo sapiens_hsa051450.21973406
139B cell receptor signaling pathway_Homo sapiens_hsa046620.20490589
140mTOR signaling pathway_Homo sapiens_hsa041500.20151645
141Tight junction_Homo sapiens_hsa045300.18985844
142Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.18375741
143Leukocyte transendothelial migration_Homo sapiens_hsa046700.18264753
144Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.17912241

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