XPO6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the importin-beta family. Members of this family are regulated by the GTPase Ran to mediate transport of cargo across the nuclear envelope. This protein has been shown to mediate nuclear export of profilin-actin complexes. A pseudogene of this gene is located on the long arm of chromosome 14. Alternative splicing results in multiple transcript variants that encode different protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.21710623
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.96305467
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.96305467
4modulation by symbiont of host immune response (GO:0052553)5.96305467
5positive regulation by symbiont of host defense response (GO:0052509)5.96305467
6modulation by symbiont of host defense response (GO:0052031)5.96305467
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.96305467
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.85673945
9antigen processing and presentation of endogenous antigen (GO:0019883)5.45799422
10nuclear pore complex assembly (GO:0051292)5.35532859
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.28964265
12macrophage activation involved in immune response (GO:0002281)4.97469439
13detection of other organism (GO:0098543)4.78091662
14nuclear pore organization (GO:0006999)4.68850621
15regulation of B cell receptor signaling pathway (GO:0050855)4.67872906
16detection of molecule of bacterial origin (GO:0032490)4.64598574
17neutrophil activation involved in immune response (GO:0002283)4.51353582
18detection of bacterium (GO:0016045)4.49098680
19response to interleukin-15 (GO:0070672)4.47084691
20detection of external biotic stimulus (GO:0098581)4.37308387
21pre-miRNA processing (GO:0031054)4.33555607
22response to peptidoglycan (GO:0032494)4.32082239
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.25251460
24cellular extravasation (GO:0045123)4.24590515
25pore complex assembly (GO:0046931)4.20973422
26positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.19553077
27regulation of interferon-beta biosynthetic process (GO:0045357)4.18241539
28negative regulation of lymphocyte mediated immunity (GO:0002707)4.13615603
29negative regulation of interleukin-12 production (GO:0032695)4.07401411
30response to host immune response (GO:0052572)3.99043425
31response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.99043425
32cellular response to interleukin-15 (GO:0071350)3.95581333
33mitotic sister chromatid cohesion (GO:0007064)3.89988757
34response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.83087488
35response to host (GO:0075136)3.83087488
36response to host defenses (GO:0052200)3.83087488
37respiratory burst (GO:0045730)3.79657116
38detection of biotic stimulus (GO:0009595)3.77239892
39negative regulation of histone methylation (GO:0031061)3.76720189
40leukocyte migration involved in inflammatory response (GO:0002523)3.72487859
41microglial cell activation (GO:0001774)3.72242376
42neutrophil activation (GO:0042119)3.68818366
43negative regulation of leukocyte mediated immunity (GO:0002704)3.68810370
44negative regulation of erythrocyte differentiation (GO:0045647)3.60717694
45antigen processing and presentation via MHC class Ib (GO:0002475)3.58128657
46positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.56652884
47macrophage activation (GO:0042116)3.54400256
48negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.54229754
49regulation of RNA export from nucleus (GO:0046831)3.51972075
50regulation of histone H3-K9 methylation (GO:0051570)3.48403517
51negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.47964922
52negative regulation of T cell mediated immunity (GO:0002710)3.47528002
53B cell receptor signaling pathway (GO:0050853)3.46224152
54histone H3-K4 trimethylation (GO:0080182)3.46183972
55myeloid cell activation involved in immune response (GO:0002275)3.43122845
56type I interferon signaling pathway (GO:0060337)3.41676753
57cellular response to type I interferon (GO:0071357)3.41676753
58positive regulation of gamma-delta T cell activation (GO:0046645)3.39309366
59response to type I interferon (GO:0034340)3.38951114
60neutrophil mediated immunity (GO:0002446)3.35256334
61granulocyte activation (GO:0036230)3.33512855
62production of molecular mediator involved in inflammatory response (GO:0002532)3.31652575
63response to muramyl dipeptide (GO:0032495)3.31602784
64immunoglobulin mediated immune response (GO:0016064)3.29165717
65dosage compensation (GO:0007549)3.28192553
66regulation of mast cell degranulation (GO:0043304)3.26960610
67histone H3-K9 methylation (GO:0051567)3.25465084
68positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.25364730
69germinal center formation (GO:0002467)3.24262438
70positive regulation of histone deacetylation (GO:0031065)3.19827073
71histone H3-K4 methylation (GO:0051568)3.17895317
72negative regulation of phagocytosis (GO:0050765)3.15411166
73protein-DNA complex disassembly (GO:0032986)3.14982098
74nucleosome disassembly (GO:0006337)3.14982098
75regulation of myeloid leukocyte mediated immunity (GO:0002886)3.13361125
76regulation of T cell tolerance induction (GO:0002664)3.12446747
77regulation of T-helper 2 cell differentiation (GO:0045628)3.11140933
78regulation of leukocyte degranulation (GO:0043300)3.11039272
79regulation of B cell differentiation (GO:0045577)3.08973293
80tolerance induction (GO:0002507)3.04106674
81NLS-bearing protein import into nucleus (GO:0006607)3.00686061
82regulation of protein polyubiquitination (GO:1902914)2.97998927
83lipopolysaccharide-mediated signaling pathway (GO:0031663)2.97945362
84RNA stabilization (GO:0043489)2.97424447
85mRNA stabilization (GO:0048255)2.97424447
86regulation of tolerance induction (GO:0002643)2.96558162
87negative regulation of T-helper cell differentiation (GO:0045623)2.95813789
88negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.95813789
89histone H3-K9 modification (GO:0061647)2.95433553
90gene silencing by RNA (GO:0031047)2.95306525
91regulation of mast cell activation involved in immune response (GO:0033006)2.94704942
92negative thymic T cell selection (GO:0045060)2.92883511
93peptidyl-lysine trimethylation (GO:0018023)2.92848723
94negative T cell selection (GO:0043383)2.92823055
95mitotic nuclear envelope disassembly (GO:0007077)2.91709005
96positive thymic T cell selection (GO:0045059)2.91645930
97negative regulation of type 2 immune response (GO:0002829)2.90729802
98myeloid leukocyte mediated immunity (GO:0002444)2.90487384
99defense response to protozoan (GO:0042832)2.90464344
100histone lysine methylation (GO:0034968)2.89469701
101regulation of nucleobase-containing compound transport (GO:0032239)2.88740390
102positive regulation of B cell differentiation (GO:0045579)2.86079593
103leukocyte degranulation (GO:0043299)2.85258259
104regulation of natural killer cell mediated immunity (GO:0002715)2.83580110
105regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.83580110
106positive regulation of interferon-alpha production (GO:0032727)2.81588257
107heterochromatin organization (GO:0070828)2.80920822
108positive regulation of gene expression, epigenetic (GO:0045815)2.80757580
109dendritic cell migration (GO:0036336)2.80064921
110negative regulation of cell killing (GO:0031342)2.79927611
111negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.79927611
112positive T cell selection (GO:0043368)2.79776942
113monoubiquitinated protein deubiquitination (GO:0035520)2.78956029
114cytoplasmic mRNA processing body assembly (GO:0033962)2.78780637
115gene silencing (GO:0016458)2.78651546
116regulation of centriole replication (GO:0046599)2.78384616
117positive regulation of Cdc42 GTPase activity (GO:0043089)2.78276309
118regulation of T cell mediated cytotoxicity (GO:0001914)2.78085008
119negative regulation of innate immune response (GO:0045824)2.78078831
120regulation of chromatin binding (GO:0035561)2.78006004
121dendritic cell chemotaxis (GO:0002407)2.77822115
122T cell migration (GO:0072678)2.77563713
123positive regulation of T cell mediated cytotoxicity (GO:0001916)2.76799475
124regulation of interleukin-12 biosynthetic process (GO:0045075)2.76656479
125negative regulation of translation, ncRNA-mediated (GO:0040033)2.76248918
126regulation of translation, ncRNA-mediated (GO:0045974)2.76248918
127negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.76248918
128membrane disassembly (GO:0030397)2.76012413
129nuclear envelope disassembly (GO:0051081)2.76012413
130negative regulation of DNA repair (GO:0045738)2.75981129
131regulation of gamma-delta T cell differentiation (GO:0045586)2.75943179
132histone H4-K16 acetylation (GO:0043984)2.75860597
133regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.74966957
134histone H3-K36 demethylation (GO:0070544)2.74893309
135regulation of necroptotic process (GO:0060544)2.74776512
136DNA duplex unwinding (GO:0032508)2.74606201
137DNA geometric change (GO:0032392)2.73962911
138negative regulation of toll-like receptor signaling pathway (GO:0034122)2.73876280
139sister chromatid segregation (GO:0000819)2.73793030
140regulation of alpha-beta T cell proliferation (GO:0046640)2.72941253
141translesion synthesis (GO:0019985)2.72639733
142intracellular estrogen receptor signaling pathway (GO:0030520)2.72160170
143regulation of gamma-delta T cell activation (GO:0046643)2.70347058
144chromatin assembly (GO:0031497)2.67736008
145histone H4-K8 acetylation (GO:0043982)2.66902868
146histone H4-K5 acetylation (GO:0043981)2.66902868
147negative regulation of gene expression, epigenetic (GO:0045814)2.65664840
148regulation of NFAT protein import into nucleus (GO:0051532)2.64752699
149peptidyl-lysine dimethylation (GO:0018027)2.62929266
150regulation of histone methylation (GO:0031060)2.62519177
151chromatin silencing (GO:0006342)2.61929645
152histone H3-K9 demethylation (GO:0033169)2.60664134
153thymic T cell selection (GO:0045061)2.60655569
154negative regulation of histone modification (GO:0031057)2.60368561
155peptidyl-lysine methylation (GO:0018022)2.60322866
156T cell selection (GO:0045058)2.60195204
157histone methylation (GO:0016571)2.59147513
158regulation of DNA endoreduplication (GO:0032875)2.58271061
159histone H2A acetylation (GO:0043968)2.58089170
160histone H2A monoubiquitination (GO:0035518)2.57364728
161protein localization to chromosome, centromeric region (GO:0071459)2.56447820
162mitotic chromosome condensation (GO:0007076)2.55186942
163synaptonemal complex assembly (GO:0007130)2.54670006
164microtubule depolymerization (GO:0007019)2.54306323
165histone H4 acetylation (GO:0043967)2.53906242
166DNA unwinding involved in DNA replication (GO:0006268)2.52340834
167paraxial mesoderm development (GO:0048339)2.49857003
168regulation of telomere maintenance via telomerase (GO:0032210)2.49713013
169mitotic sister chromatid segregation (GO:0000070)2.49185774
170negative regulation of chromatin modification (GO:1903309)2.48812662
171histone H4-K12 acetylation (GO:0043983)2.48621953
172leukocyte aggregation (GO:0070486)2.48558605
173protein localization to kinetochore (GO:0034501)2.43873000
174DNA alkylation (GO:0006305)2.43844938
175DNA methylation (GO:0006306)2.43844938
176positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.43613357
177positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.43613357
178positive regulation of mitotic sister chromatid separation (GO:1901970)2.43613357
179regulation of translational fidelity (GO:0006450)2.40460941
180histone mRNA catabolic process (GO:0071044)2.39307624
181snRNA processing (GO:0016180)2.37375745
182regulation of mRNA stability (GO:0043488)2.36748056
183regulation of histone H3-K4 methylation (GO:0051569)2.35582447
184regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.35496391
185DNA conformation change (GO:0071103)2.35073487
186nucleus organization (GO:0006997)2.34473565
187histone lysine demethylation (GO:0070076)2.34323435
188snRNA metabolic process (GO:0016073)2.34103210

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.57410984
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.07682345
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.83313502
4* MYC_22102868_ChIP-Seq_BL_Human3.77214041
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.23382129
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.22993451
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.13134049
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.85681441
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.84041349
10TCF7_22412390_ChIP-Seq_EML_Mouse2.41518343
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.36770064
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.33668426
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.27750909
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.25686806
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.22451226
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.15728494
17KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.14071690
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.12603566
19KDM2B_26808549_Chip-Seq_DND41_Human2.09995325
20VDR_21846776_ChIP-Seq_THP-1_Human2.04552347
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.04369876
22STAT6_21828071_ChIP-Seq_BEAS2B_Human2.02968049
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.00418594
24* CIITA_25753668_ChIP-Seq_RAJI_Human1.97271687
25KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.96742643
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.91133769
27* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.85646931
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.82348303
29MYB_26560356_Chip-Seq_TH1_Human1.81539427
30* MAF_26560356_Chip-Seq_TH1_Human1.78486245
31UTX_26944678_Chip-Seq_JUKART_Human1.78357353
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.74551694
33SCL_19346495_ChIP-Seq_HPC-7_Human1.73832047
34MYB_26560356_Chip-Seq_TH2_Human1.71504879
35SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.70548391
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69060315
37LXR_22292898_ChIP-Seq_THP-1_Human1.68148043
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66776050
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63839653
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.59856457
41SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.58246353
42ZFP281_27345836_Chip-Seq_ESCs_Mouse1.57538697
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.51803049
44* GATA1_19941827_ChIP-Seq_MEL_Mouse1.48769676
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.47601519
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45968575
47CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.43386077
48RUNX_20019798_ChIP-Seq_JUKART_Human1.41594935
49CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39498090
50GATA1_22383799_ChIP-Seq_G1ME_Mouse1.38804029
51Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.38209403
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37448639
53DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.37013301
54SPI1_23127762_ChIP-Seq_K562_Human1.35444737
55KDM2B_26808549_Chip-Seq_JURKAT_Human1.34672417
56* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34290378
57MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.34113103
58PKCTHETA_26484144_Chip-Seq_BREAST_Human1.33471767
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32251131
60* RACK7_27058665_Chip-Seq_MCF-7_Human1.30678195
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27537916
62PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27317723
63* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.26141792
64PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25005825
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24640322
66SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.23074837
67RUNX1_22412390_ChIP-Seq_EML_Mouse1.21968875
68E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.21033182
69IRF8_22096565_ChIP-ChIP_GC-B_Human1.20189521
70* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17519483
71PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17258634
72STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17097367
73VDR_24787735_ChIP-Seq_THP-1_Human1.16730978
74MAF_26560356_Chip-Seq_TH2_Human1.16681097
75VDR_24763502_ChIP-Seq_THP-1_Human1.15198725
76CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14490003
77* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14155402
78* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12545346
79GATA1_19941826_ChIP-Seq_K562_Human1.11516010
80IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.10644118
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10232464
82CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09422220
83ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09026354
84NCOR1_26117541_ChIP-Seq_K562_Human1.08751110
85MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08716285
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06353906
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.05631908
88NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04305501
89FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.04074523
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03002635
91SA1_27219007_Chip-Seq_ERYTHROID_Human1.00994781
92CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99358044
93* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98846397
94ELK3_25401928_ChIP-Seq_HUVEC_Human0.98426290
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97061253
96ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95765969
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95499667
98TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93783812
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93735567
100KDM2B_26808549_Chip-Seq_K562_Human0.93618418
101GATA2_21666600_ChIP-Seq_HMVEC_Human0.93542017
102BCOR_27268052_Chip-Seq_Bcells_Human0.93469458
103TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93423603
104IRF8_27001747_Chip-Seq_BMDM_Mouse0.92756866
105GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92632501
106ELK4_26923725_Chip-Seq_MESODERM_Mouse0.92604608
107SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92602341
108AR_21909140_ChIP-Seq_LNCAP_Human0.91658076
109CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.91503745
110SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91011266
111BCL6_27268052_Chip-Seq_Bcells_Human0.90632408
112* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.90588722
113NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90027443
114RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.89774932
115PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89624072
116GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89510116
117GATA3_27048872_Chip-Seq_THYMUS_Human0.89361484
118P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88789667
119SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88454205
120ZFP281_18757296_ChIP-ChIP_E14_Mouse0.88347811
121TP63_17297297_ChIP-ChIP_HaCaT_Human0.86433849
122FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.86419192
123POU5F1_16518401_ChIP-PET_MESCs_Mouse0.84823411
124BP1_19119308_ChIP-ChIP_Hs578T_Human0.84592883
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.83230650
126* IRF8_21731497_ChIP-ChIP_J774_Mouse0.82797351
127EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.82753373
128PU_27001747_Chip-Seq_BMDM_Mouse0.82598908
129KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.81280547
130MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.81230758
131TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.80743997
132GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80425309
133* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.79818626
134* IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.77977386
135KDM5A_27292631_Chip-Seq_BREAST_Human0.77708839
136TP53_22127205_ChIP-Seq_IMR90_Human0.77165867
137KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.75912151
138GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.74511986
139SPI1_23547873_ChIP-Seq_NB4_Human0.74040689
140RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.73326906
141* MYC_19079543_ChIP-ChIP_MESCs_Mouse0.73067302
142GATA1_26923725_Chip-Seq_HPCs_Mouse0.73001855
143NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.72416137

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.45863791
2MP0000569_abnormal_digit_pigmentation3.89091027
3MP0008057_abnormal_DNA_replication3.06518226
4MP0003111_abnormal_nucleus_morphology2.90653694
5MP0002419_abnormal_innate_immunity2.87146839
6MP0008260_abnormal_autophagy2.81324804
7MP0010094_abnormal_chromosome_stability2.76862816
8MP0005076_abnormal_cell_differentiation2.73704962
9MP0003787_abnormal_imprinting2.64102718
10MP0005025_abnormal_response_to2.61668186
11MP0003191_abnormal_cellular_cholesterol2.46622992
12MP0002396_abnormal_hematopoietic_system2.46071256
13MP0009785_altered_susceptibility_to2.32961459
14MP0009278_abnormal_bone_marrow2.26036233
15MP0003763_abnormal_thymus_physiology2.25799585
16MP0003077_abnormal_cell_cycle2.25511008
17MP0005451_abnormal_body_composition2.24313173
18MP0006082_CNS_inflammation2.23970583
19MP0005410_abnormal_fertilization2.08559209
20MP0008877_abnormal_DNA_methylation2.02178219
21MP0004808_abnormal_hematopoietic_stem2.01634686
22MP0001533_abnormal_skeleton_physiology1.99732809
23MP0010352_gastrointestinal_tract_polyps1.95219451
24MP0010307_abnormal_tumor_latency1.92665722
25MP0004947_skin_inflammation1.84775292
26MP0005464_abnormal_platelet_physiology1.82788102
27MP0008058_abnormal_DNA_repair1.77197533
28MP0002132_abnormal_respiratory_system1.76456722
29MP0000703_abnormal_thymus_morphology1.75708287
30MP0003121_genomic_imprinting1.72839578
31MP0002148_abnormal_hypersensitivity_rea1.72193411
32MP0003828_pulmonary_edema1.70182377
33MP0004381_abnormal_hair_follicle1.69552384
34MP0003693_abnormal_embryo_hatching1.69285503
35MP0010155_abnormal_intestine_physiology1.67630095
36MP0003705_abnormal_hypodermis_morpholog1.65380467
37MP0000685_abnormal_immune_system1.64321658
38MP0002398_abnormal_bone_marrow1.62297089
39MP0005397_hematopoietic_system_phenotyp1.59092221
40MP0001545_abnormal_hematopoietic_system1.59092221
41MP0004197_abnormal_fetal_growth/weight/1.57974909
42MP0000733_abnormal_muscle_development1.57253305
43MP0008007_abnormal_cellular_replicative1.56467842
44MP0001800_abnormal_humoral_immune1.55614097
45MP0000350_abnormal_cell_proliferation1.52286469
46MP0004957_abnormal_blastocyst_morpholog1.50923103
47MP0001845_abnormal_inflammatory_respons1.50905502
48MP0001293_anophthalmia1.48283626
49MP0001835_abnormal_antigen_presentation1.47349710
50MP0004510_myositis1.45524403
51MP0003300_gastrointestinal_ulcer1.43498752
52MP0001730_embryonic_growth_arrest1.41536184
53MP0001672_abnormal_embryogenesis/_devel1.40837550
54MP0005380_embryogenesis_phenotype1.40837550
55MP0008961_abnormal_basal_metabolism1.40318383
56MP0004883_abnormal_blood_vessel1.38270899
57MP0005310_abnormal_salivary_gland1.37954942
58MP0005387_immune_system_phenotype1.37651793
59MP0001790_abnormal_immune_system1.37651793
60MP0002086_abnormal_extraembryonic_tissu1.37626401
61MP0000465_gastrointestinal_hemorrhage1.37222584
62MP0003183_abnormal_peptide_metabolism1.36501625
63MP0002084_abnormal_developmental_patter1.35183794
64MP0003984_embryonic_growth_retardation1.33685693
65MP0002088_abnormal_embryonic_growth/wei1.31155818
66MP0001929_abnormal_gametogenesis1.30420062
67MP0001851_eye_inflammation1.29958471
68MP0002085_abnormal_embryonic_tissue1.28624224
69MP0002998_abnormal_bone_remodeling1.22367959
70MP0002452_abnormal_antigen_presenting1.22140635
71MP0005671_abnormal_response_to1.21947238
72MP0008469_abnormal_protein_level1.21414093
73MP0000716_abnormal_immune_system1.20217778
74MP0002722_abnormal_immune_system1.19065946
75MP0002420_abnormal_adaptive_immunity1.19048488
76MP0001819_abnormal_immune_cell1.18368697
77MP0003698_abnormal_male_reproductive1.17836069
78MP0002277_abnormal_respiratory_mucosa1.17435011
79MP0002210_abnormal_sex_determination1.16922960
80MP0002405_respiratory_system_inflammati1.15310139
81MP0001697_abnormal_embryo_size1.14511056
82MP0003172_abnormal_lysosome_physiology1.14422732
83MP0003303_peritoneal_inflammation1.13913162
84MP0003890_abnormal_embryonic-extraembry1.13585188
85MP0009703_decreased_birth_body1.12083682
86MP0002723_abnormal_immune_serum1.11332786
87MP0000689_abnormal_spleen_morphology1.09672043
88MP0005164_abnormal_response_to1.09277514
89MP0005174_abnormal_tail_pigmentation1.08488498
90MP0003566_abnormal_cell_adhesion1.06984083
91MP0002925_abnormal_cardiovascular_devel1.06361425
92MP0000313_abnormal_cell_death1.06294847
93MP0004858_abnormal_nervous_system1.05938342
94MP0009672_abnormal_birth_weight1.05586350
95MP0003091_abnormal_cell_migration1.04594677
96MP0003690_abnormal_glial_cell1.04273610
97MP0002429_abnormal_blood_cell1.04042340
98MP0003448_altered_tumor_morphology1.02432052
99MP0002006_tumorigenesis1.02390045
100MP0003123_paternal_imprinting1.02298885
101MP0000490_abnormal_crypts_of1.02251711
102MP0002166_altered_tumor_susceptibility1.01639691
103MP0002080_prenatal_lethality0.99960166
104MP0003075_altered_response_to0.99755704
105MP0009333_abnormal_splenocyte_physiolog0.99265842
106MP0009764_decreased_sensitivity_to0.98946430
107MP0001145_abnormal_male_reproductive0.98812066
108MP0005000_abnormal_immune_tolerance0.95749817
109MP0003436_decreased_susceptibility_to0.94652391
110MP0002019_abnormal_tumor_incidence0.93839712
111MP0004185_abnormal_adipocyte_glucose0.91887240
112MP0005058_abnormal_lysosome_morphology0.91038866
113MP0003115_abnormal_respiratory_system0.89819691
114MP0003045_fibrosis0.89357385
115MP0002877_abnormal_melanocyte_morpholog0.89319178
116MP0005623_abnormal_meninges_morphology0.88558889
117MP0003221_abnormal_cardiomyocyte_apopto0.87849909
118MP0004264_abnormal_extraembryonic_tissu0.87500515
119MP0000371_diluted_coat_color0.86723732
120MP0002653_abnormal_ependyma_morphology0.86558468
121MP0005390_skeleton_phenotype0.86010670
122MP0000428_abnormal_craniofacial_morphol0.85804904
123MP0002092_abnormal_eye_morphology0.85332728
124MP0000015_abnormal_ear_pigmentation0.85117056
125MP0005166_decreased_susceptibility_to0.84510325
126MP0003935_abnormal_craniofacial_develop0.83201269
127MP0000858_altered_metastatic_potential0.82883946
128MP0001915_intracranial_hemorrhage0.82410455
129MP0008770_decreased_survivor_rate0.81109988
130MP0005621_abnormal_cell_physiology0.79077490
131MP0001873_stomach_inflammation0.78951201
132MP0003861_abnormal_nervous_system0.78659365
133MP0003453_abnormal_keratinocyte_physiol0.78574804
134MP0000566_synostosis0.78352057
135MP0001853_heart_inflammation0.78298549
136MP0003950_abnormal_plasma_membrane0.78019470
137MP0000653_abnormal_sex_gland0.76402426
138MP0003941_abnormal_skin_development0.76031666
139MP0003866_abnormal_defecation0.74880676
140MP0005409_darkened_coat_color0.74493061
141MP0001958_emphysema0.73808613
142MP0003656_abnormal_erythrocyte_physiolo0.72222331
143MP0001348_abnormal_lacrimal_gland0.71051279
144MP0009763_increased_sensitivity_to0.70940873
145MP0001663_abnormal_digestive_system0.70568093
146MP0008004_abnormal_stomach_pH0.69686601
147MP0002009_preneoplasia0.67815359
148MP0003795_abnormal_bone_structure0.67206116
149MP0000604_amyloidosis0.66247239
150MP0001849_ear_inflammation0.65486372
151MP0005023_abnormal_wound_healing0.63561954
152MP0008874_decreased_physiological_sensi0.62630405
153MP0002933_joint_inflammation0.59495125
154MP0004130_abnormal_muscle_cell0.58835778
155MP0000249_abnormal_blood_vessel0.57977719

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.28129478
2Recurrent abscess formation (HP:0002722)5.27938702
3Recurrent bacterial skin infections (HP:0005406)5.18487768
4Myositis (HP:0100614)5.12782329
5Orchitis (HP:0100796)4.92245947
6Abnormality of macrophages (HP:0004311)4.56432408
7Retrobulbar optic neuritis (HP:0100654)4.45965416
8Optic neuritis (HP:0100653)4.45965416
9Gastrointestinal infarctions (HP:0005244)4.12506786
10Elevated erythrocyte sedimentation rate (HP:0003565)4.06803619
11Recurrent gram-negative bacterial infections (HP:0005420)4.03751242
12Stomatitis (HP:0010280)3.77917232
13Obstructive lung disease (HP:0006536)3.72289187
14Chronic obstructive pulmonary disease (HP:0006510)3.72289187
15Abnormality of the fingertips (HP:0001211)3.62648061
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.59918197
17Mediastinal lymphadenopathy (HP:0100721)3.58736952
18Increased IgE level (HP:0003212)3.54382639
19Spontaneous hematomas (HP:0007420)3.54349805
20Meningitis (HP:0001287)3.53990751
21Gingivitis (HP:0000230)3.50302076
22Recurrent skin infections (HP:0001581)3.45557642
23Peritonitis (HP:0002586)3.41039015
24Chromosomal breakage induced by crosslinking agents (HP:0003221)3.33310423
25Keratoconjunctivitis sicca (HP:0001097)3.30323055
26Recurrent cutaneous fungal infections (HP:0011370)3.23919025
27Chronic mucocutaneous candidiasis (HP:0002728)3.23919025
28Chromsome breakage (HP:0040012)3.20468361
29Encephalitis (HP:0002383)3.16577608
30Hypochromic microcytic anemia (HP:0004840)3.16381290
31Ectopic kidney (HP:0000086)3.14329671
32Urticaria (HP:0001025)3.13597745
33Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.12951476
34Vasculitis (HP:0002633)3.09696853
35Keratoconjunctivitis (HP:0001096)3.02897895
36Hypochromic anemia (HP:0001931)3.02650801
37Chest pain (HP:0100749)2.98035232
38Volvulus (HP:0002580)2.85789630
39Heterotopia (HP:0002282)2.81311100
40Prolonged bleeding time (HP:0003010)2.80255247
41Short 4th metacarpal (HP:0010044)2.74980617
42Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.74980617
43Gastrointestinal inflammation (HP:0004386)2.65222242
44Inflammation of the large intestine (HP:0002037)2.59564273
45Arterial thrombosis (HP:0004420)2.59461926
46Abnormality of the peritoneum (HP:0002585)2.59336267
47Long eyelashes (HP:0000527)2.56195168
48Episodic fever (HP:0001954)2.56101798
49Gingival bleeding (HP:0000225)2.55317231
50Slow saccadic eye movements (HP:0000514)2.53280841
51Subacute progressive viral hepatitis (HP:0006572)2.53187644
52Pustule (HP:0200039)2.49223326
53Hemoptysis (HP:0002105)2.48989927
54Hyperacusis (HP:0010780)2.46397983
55Pulmonary infiltrates (HP:0002113)2.44465513
56Osteomyelitis (HP:0002754)2.43590134
57Abnormality of T cells (HP:0002843)2.40948476
58Anorexia (HP:0002039)2.38857104
59Leukocytosis (HP:0001974)2.37870373
60Epistaxis (HP:0000421)2.37731330
61Trigonocephaly (HP:0000243)2.34581720
62Macroorchidism (HP:0000053)2.31006012
63Granulocytopenia (HP:0001913)2.28125467
64Pulmonary embolism (HP:0002204)2.26142855
65Prominent nose (HP:0000448)2.25911206
66Viral hepatitis (HP:0006562)2.25483171
67Abnormality of DNA repair (HP:0003254)2.25139494
68Absent frontal sinuses (HP:0002688)2.24145950
69Colitis (HP:0002583)2.21822917
70Lymphopenia (HP:0001888)2.21595091
71Sepsis (HP:0100806)2.20488189
72Abnormality of cells of the lymphoid lineage (HP:0012140)2.18345002
73Abnormality of chromosome stability (HP:0003220)2.16228421
74Metaphyseal cupping (HP:0003021)2.15667476
75Segmental peripheral demyelination/remyelination (HP:0003481)2.14671993
76Microcytic anemia (HP:0001935)2.12587653
77Increased IgM level (HP:0003496)2.12400950
78Abnormal platelet volume (HP:0011876)2.11818595
79Basal cell carcinoma (HP:0002671)2.11712785
80Supernumerary ribs (HP:0005815)2.10358412
81Increased nuchal translucency (HP:0010880)2.06076048
82Aplasia/Hypoplasia of the uvula (HP:0010293)2.05269719
83Glomerulopathy (HP:0100820)2.05139337
84Skin ulcer (HP:0200042)2.04570309
85Renovascular hypertension (HP:0100817)2.03631605
86Abnormality of T cell physiology (HP:0011840)2.01829462
87Abnormality of the carotid arteries (HP:0005344)2.01772706
88Amyloidosis (HP:0011034)2.00000568
89Abnormality of the ileum (HP:0001549)1.99349033
90Obsessive-compulsive behavior (HP:0000722)1.97353983
91Hypergammaglobulinemia (HP:0010702)1.97225912
92Skull defect (HP:0001362)1.95474377
93Neoplasm of the oral cavity (HP:0100649)1.95080357
94Abnormality of the endocardium (HP:0004306)1.94743123
95Ependymoma (HP:0002888)1.94729234
96Truncal obesity (HP:0001956)1.94462040
97Recurrent fungal infections (HP:0002841)1.93994949
98Renal duplication (HP:0000075)1.93945540
99Abnormality of the pleura (HP:0002103)1.93846882
100Acute myeloid leukemia (HP:0004808)1.93313811
101Elfin facies (HP:0004428)1.93214599
102Recurrent viral infections (HP:0004429)1.93182035
103Broad palm (HP:0001169)1.92810100
104Deep philtrum (HP:0002002)1.92483385
105T lymphocytopenia (HP:0005403)1.91611244
106Urethral obstruction (HP:0000796)1.90470689
107Dilatation of the ascending aorta (HP:0005111)1.88272492
108Polycythemia (HP:0001901)1.87400502
109Absent/shortened dynein arms (HP:0200106)1.87168096
110Dynein arm defect of respiratory motile cilia (HP:0012255)1.87168096
111Syringomyelia (HP:0003396)1.86393236
112Spinal cord lesions (HP:0100561)1.86393236
113Meckel diverticulum (HP:0002245)1.86367013
114Supernumerary bones of the axial skeleton (HP:0009144)1.85514318
115Acute hepatic failure (HP:0006554)1.83724299
116Medulloblastoma (HP:0002885)1.82717192
117Gangrene (HP:0100758)1.82177644
118Nasal polyposis (HP:0100582)1.81558154
119Neoplasm of the adrenal cortex (HP:0100641)1.81092281
120Abnormality of the astrocytes (HP:0100707)1.80931569
121Astrocytoma (HP:0009592)1.80931569
122Abnormality of the 4th metacarpal (HP:0010012)1.80521378
123Papilloma (HP:0012740)1.79697634
124Verrucae (HP:0200043)1.79697634
125Abnormality of the pericardium (HP:0001697)1.79436104
126Hypermelanotic macule (HP:0001034)1.79420502
127Recurrent bronchitis (HP:0002837)1.78646532
128Petechiae (HP:0000967)1.78313714
129Acne (HP:0001061)1.76910577
130Abnormality of T cell number (HP:0011839)1.76147498
131Limited elbow extension (HP:0001377)1.76141613
132Impulsivity (HP:0100710)1.74853732
133Gastrointestinal stroma tumor (HP:0100723)1.74714657
134Premature loss of primary teeth (HP:0006323)1.74209313
135Narrow palate (HP:0000189)1.73853088
136Keratitis (HP:0000491)1.72431551
137Panhypogammaglobulinemia (HP:0003139)1.71295749
138Myelodysplasia (HP:0002863)1.71028550
139Selective tooth agenesis (HP:0001592)1.70273798
140Glioma (HP:0009733)1.69692022
141Cheilitis (HP:0100825)1.68869695
142Micronodular cirrhosis (HP:0001413)1.68629185
143Eosinophilia (HP:0001880)1.68431854
144Abnormal number of incisors (HP:0011064)1.68194549
145Squamous cell carcinoma (HP:0002860)1.67667902
146Interstitial pulmonary disease (HP:0006530)1.67624534
147Clubbing of toes (HP:0100760)1.67355421
148Dislocated radial head (HP:0003083)1.67055687
149IgM deficiency (HP:0002850)1.67015607
150Aseptic necrosis (HP:0010885)1.66756509
151Depressed nasal tip (HP:0000437)1.66349803
152Autoimmune hemolytic anemia (HP:0001890)1.66272284
153Cutis marmorata (HP:0000965)1.64955846
154Sandal gap (HP:0001852)1.64940467
155Loss of speech (HP:0002371)1.64655257
156High pitched voice (HP:0001620)1.64339193
157Duplicated collecting system (HP:0000081)1.62830726
158Overriding aorta (HP:0002623)1.62770863
159Deviation of the thumb (HP:0009603)1.61083202
160Poikiloderma (HP:0001029)1.60867377
161Anal stenosis (HP:0002025)1.60312889
162Proximal placement of thumb (HP:0009623)1.59411190
163Vertebral arch anomaly (HP:0008438)1.58972667
164Cafe-au-lait spot (HP:0000957)1.58395936
165Skin tags (HP:0010609)1.58012501
166Low anterior hairline (HP:0000294)1.57660991
167Rib fusion (HP:0000902)1.57052215
168Abnormality of the preputium (HP:0100587)1.56943885
169Increased density of long bones (HP:0006392)1.56877806
170Long palpebral fissure (HP:0000637)1.56236208
171Broad phalanges of the hand (HP:0009768)1.56152565
172Broad thumb (HP:0011304)1.54388677
173Pointed chin (HP:0000307)1.54165482
174Overlapping toe (HP:0001845)1.53896242
175Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.53883226
176Abnormality of the intervertebral disk (HP:0005108)1.52627562
177Abnormality of the radial head (HP:0003995)1.52364104
178Spina bifida occulta (HP:0003298)1.52283908
179Abnormality of the labia minora (HP:0012880)1.49812452
180Flat cornea (HP:0007720)1.46647888
181Abnormality of the renal collecting system (HP:0004742)1.46533527
182Abnormality of the nasal septum (HP:0000419)1.46472665
183Sparse scalp hair (HP:0002209)1.45956236
184Blepharophimosis (HP:0000581)1.45650788
185Persistence of primary teeth (HP:0006335)1.45471144
186Abnormality of the lower motor neuron (HP:0002366)1.44360556
187Smooth philtrum (HP:0000319)1.44360517
188Tented upper lip vermilion (HP:0010804)1.43304237
189Shallow orbits (HP:0000586)1.43233578
190Cellulitis (HP:0100658)1.42405141

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.86030440
2RIPK44.22452652
3IRAK43.21011636
4MAP2K33.10567877
5ERN13.07253852
6BRD42.91427149
7EEF2K2.86014302
8ICK2.85945356
9NEK22.63728380
10MAP4K12.55432480
11BLK2.43267256
12MAP3K102.31348625
13CDC72.17727268
14SMG12.04368089
15FES1.95999830
16KSR21.86915563
17JAK31.80614988
18TRIB31.79783837
19TAOK11.77690800
20CAMK1G1.75591538
21MAP3K31.75373413
22PRKD31.75255757
23ALK1.59562473
24LATS11.58629109
25ATR1.57415429
26STK101.51241348
27MTOR1.49470355
28FGR1.45912446
29EPHA21.41906387
30MAP3K111.41249709
31SIK21.39544601
32TXK1.36329068
33MAP3K11.35498865
34TTK1.33877867
35CAMK1D1.33444651
36CHEK11.31843274
37MAP3K131.30272765
38CDK41.30203557
39MAP3K141.25511426
40PKN21.21827349
41CHUK1.21040404
42CHEK21.20337151
43YES11.18826821
44SYK1.18226028
45IRAK21.18050644
46STK31.13495417
47SGK31.13392860
48EPHB11.09636847
49ATM1.08211782
50PRKD21.07576882
51STK41.05942075
52CDK71.05499479
53PNCK1.05457636
54FGFR31.04137501
55TBK11.00331993
56RPS6KA41.00295181
57IRAK10.99479855
58TAOK20.99258144
59LYN0.99084892
60HCK0.98481136
61PIM10.98091295
62PASK0.96407185
63ITK0.93567837
64MAP3K20.93307679
65ZAP700.92956695
66MAP3K70.92080108
67LRRK20.91089482
68CSK0.90694781
69CDK60.88897558
70PDK10.88265076
71SGK20.87511134
72PDPK10.85652752
73MAP3K60.84059517
74CLK10.83830412
75BTK0.83790514
76CDK90.82646221
77WNK10.82022658
78CDK20.81278100
79NTRK20.78934389
80TYRO30.78304006
81RIPK10.77274187
82SIK10.77100322
83TTN0.76645116
84DMPK0.75468906
85JAK10.75225623
86STK380.74648862
87RAF10.74376898
88KSR10.74086625
89PTK60.73377950
90MELK0.73195984
91PRPF4B0.72395070
92ZAK0.72376678
93TYK20.71459109
94PDGFRB0.71173039
95SRPK10.66364070
96SIK30.65675037
97MARK20.65424172
98HIPK20.65250462
99MAP3K80.64416769
100MKNK20.63614787
101MARK30.63206604
102FGFR10.63178820
103CDC42BPA0.62507833
104FGFR40.62371804
105RET0.62343784
106TNK20.62040124
107CAMKK10.61230643
108CSNK1D0.59711962
109LCK0.59331098
110BMX0.59142626
111IRAK30.58604295
112PRKCH0.58472110
113CDK10.58212827
114MAPK140.57853462
115GRK60.56795183
116PRKDC0.56623796
117IKBKB0.56329573
118IKBKE0.55393871
119MAPK10.54629044
120TAOK30.54175224
121FYN0.53992044
122TESK20.53225274
123RPS6KB10.52870957
124DYRK1B0.52441963
125GSK3B0.51908333
126MAPK120.50586921
127PTK2B0.50397634
128STK110.49627403
129RPS6KC10.49345399
130RPS6KL10.49345399
131KIT0.48416340
132MAPK80.48383872
133TGFBR20.48012954
134MATK0.47971119
135PLK10.47730016
136AKT10.47330453
137RPS6KA10.45825318
138BMPR20.43185760
139JAK20.42727308
140CSF1R0.42350739
141MAPK100.42258518
142EPHA30.41564670
143PAK40.41472200
144MAPKAPK20.41458884
145PDGFRA0.41174757
146MAP2K40.40581391
147MAP3K50.40354911
148TEC0.39891496
149CDK190.39012488
150MAPK70.38952489

Predicted pathways (KEGG)

RankGene SetZ-score
1mRNA surveillance pathway_Homo sapiens_hsa030151.87274633
2Staphylococcus aureus infection_Homo sapiens_hsa051501.86216163
3Tuberculosis_Homo sapiens_hsa051521.81835717
4Primary immunodeficiency_Homo sapiens_hsa053401.76168242
5NF-kappa B signaling pathway_Homo sapiens_hsa040641.68197855
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.67152790
7Fanconi anemia pathway_Homo sapiens_hsa034601.66513410
8B cell receptor signaling pathway_Homo sapiens_hsa046621.60934235
9Dorso-ventral axis formation_Homo sapiens_hsa043201.60376221
10Lysine degradation_Homo sapiens_hsa003101.60310998
11Malaria_Homo sapiens_hsa051441.59140559
12T cell receptor signaling pathway_Homo sapiens_hsa046601.57912846
13Chronic myeloid leukemia_Homo sapiens_hsa052201.55499737
14Notch signaling pathway_Homo sapiens_hsa043301.52233294
15Cell cycle_Homo sapiens_hsa041101.47309437
16Measles_Homo sapiens_hsa051621.46567661
17Autoimmune thyroid disease_Homo sapiens_hsa053201.42021688
18Herpes simplex infection_Homo sapiens_hsa051681.41887589
19Acute myeloid leukemia_Homo sapiens_hsa052211.41878088
20RNA transport_Homo sapiens_hsa030131.39990819
21MicroRNAs in cancer_Homo sapiens_hsa052061.36223125
22Viral myocarditis_Homo sapiens_hsa054161.34712044
23Non-homologous end-joining_Homo sapiens_hsa034501.30254596
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.29859479
25Hepatitis C_Homo sapiens_hsa051601.24179203
26HTLV-I infection_Homo sapiens_hsa051661.22876916
27Base excision repair_Homo sapiens_hsa034101.16948979
28Osteoclast differentiation_Homo sapiens_hsa043801.16418979
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16006567
30mTOR signaling pathway_Homo sapiens_hsa041501.14863398
31DNA replication_Homo sapiens_hsa030301.13261867
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.12584541
33Leishmaniasis_Homo sapiens_hsa051401.11552689
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.11339643
35Pancreatic cancer_Homo sapiens_hsa052121.11064909
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10694337
37Viral carcinogenesis_Homo sapiens_hsa052031.10305616
38Small cell lung cancer_Homo sapiens_hsa052221.10186440
39Thyroid hormone signaling pathway_Homo sapiens_hsa049191.09572879
40Non-small cell lung cancer_Homo sapiens_hsa052231.09257678
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08777691
42Influenza A_Homo sapiens_hsa051641.08337663
43Phagosome_Homo sapiens_hsa041451.08003641
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06820649
45Hepatitis B_Homo sapiens_hsa051611.06480298
46African trypanosomiasis_Homo sapiens_hsa051431.06480293
47Platelet activation_Homo sapiens_hsa046111.05516625
48Spliceosome_Homo sapiens_hsa030401.04453681
49Colorectal cancer_Homo sapiens_hsa052101.04286355
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.04032686
51Toxoplasmosis_Homo sapiens_hsa051451.03133286
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03092468
53Antigen processing and presentation_Homo sapiens_hsa046121.02710466
54Jak-STAT signaling pathway_Homo sapiens_hsa046301.01573519
55Prolactin signaling pathway_Homo sapiens_hsa049170.99841410
56Basal cell carcinoma_Homo sapiens_hsa052170.99620405
57Endometrial cancer_Homo sapiens_hsa052130.98436666
58Adherens junction_Homo sapiens_hsa045200.98200313
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.97247257
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.96525132
61Type I diabetes mellitus_Homo sapiens_hsa049400.96418926
62Chemokine signaling pathway_Homo sapiens_hsa040620.95979823
63p53 signaling pathway_Homo sapiens_hsa041150.95744293
64Mismatch repair_Homo sapiens_hsa034300.94199007
65One carbon pool by folate_Homo sapiens_hsa006700.94087199
66Homologous recombination_Homo sapiens_hsa034400.94022465
67Prostate cancer_Homo sapiens_hsa052150.93941754
68TNF signaling pathway_Homo sapiens_hsa046680.93258898
69Endocytosis_Homo sapiens_hsa041440.92701368
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.92113348
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91882784
72Other glycan degradation_Homo sapiens_hsa005110.90960227
73Thyroid cancer_Homo sapiens_hsa052160.88888469
74Apoptosis_Homo sapiens_hsa042100.88091316
75Hematopoietic cell lineage_Homo sapiens_hsa046400.88046084
76Type II diabetes mellitus_Homo sapiens_hsa049300.87403055
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.87223080
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86276528
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84824966
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84817946
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84190036
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83954948
83Allograft rejection_Homo sapiens_hsa053300.80763583
84Glioma_Homo sapiens_hsa052140.80678079
85Proteoglycans in cancer_Homo sapiens_hsa052050.80473208
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79652532
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77667522
88GnRH signaling pathway_Homo sapiens_hsa049120.77213550
89Epstein-Barr virus infection_Homo sapiens_hsa051690.76631879
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75462380
91MAPK signaling pathway_Homo sapiens_hsa040100.75380896
92Wnt signaling pathway_Homo sapiens_hsa043100.75185406
93FoxO signaling pathway_Homo sapiens_hsa040680.74659129
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74017697
95Shigellosis_Homo sapiens_hsa051310.73592866
96Estrogen signaling pathway_Homo sapiens_hsa049150.72920218
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72584404
98Amoebiasis_Homo sapiens_hsa051460.72091379
99Pathways in cancer_Homo sapiens_hsa052000.71895006
100HIF-1 signaling pathway_Homo sapiens_hsa040660.71480350
101Pertussis_Homo sapiens_hsa051330.71434281
102Bladder cancer_Homo sapiens_hsa052190.69435109
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.69304141
104Hippo signaling pathway_Homo sapiens_hsa043900.69172401
105Inositol phosphate metabolism_Homo sapiens_hsa005620.68799147
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.67771462
107ErbB signaling pathway_Homo sapiens_hsa040120.67414567
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66927454
109VEGF signaling pathway_Homo sapiens_hsa043700.66842471
110Oocyte meiosis_Homo sapiens_hsa041140.65571564
111Hedgehog signaling pathway_Homo sapiens_hsa043400.65470104
112Renal cell carcinoma_Homo sapiens_hsa052110.64407155
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63365244
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63176811
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.63095024
116Insulin signaling pathway_Homo sapiens_hsa049100.63020726
117Asthma_Homo sapiens_hsa053100.62604282
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62200395
119Graft-versus-host disease_Homo sapiens_hsa053320.61998507
120Legionellosis_Homo sapiens_hsa051340.61684761
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61450600
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61158429
123Rap1 signaling pathway_Homo sapiens_hsa040150.59361471
124TGF-beta signaling pathway_Homo sapiens_hsa043500.58627139
125Insulin resistance_Homo sapiens_hsa049310.57624308
126Salmonella infection_Homo sapiens_hsa051320.57487445
127Choline metabolism in cancer_Homo sapiens_hsa052310.56699983
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56626272
129Basal transcription factors_Homo sapiens_hsa030220.56159393
130Focal adhesion_Homo sapiens_hsa045100.55693713
131Long-term potentiation_Homo sapiens_hsa047200.55511643
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54962297
133Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53601904

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