XPO7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the importin-beta superfamily of nuclear transport receptors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX biosynthetic process (GO:0006782)9.38255014
2porphyrin-containing compound biosynthetic process (GO:0006779)6.43282513
3tetrapyrrole biosynthetic process (GO:0033014)5.81229292
4oxygen transport (GO:0015671)5.62769669
5hemoglobin metabolic process (GO:0020027)5.58542957
6erythrocyte maturation (GO:0043249)5.37319565
7pre-miRNA processing (GO:0031054)5.23110851
8heme biosynthetic process (GO:0006783)5.13754791
9nuclear pore complex assembly (GO:0051292)5.13109442
10gas transport (GO:0015669)5.10907742
11nuclear pore organization (GO:0006999)4.88433012
12regulation of DNA endoreduplication (GO:0032875)4.83864926
13porphyrin-containing compound metabolic process (GO:0006778)4.83226500
14sister chromatid segregation (GO:0000819)4.59768738
15mitotic sister chromatid cohesion (GO:0007064)4.35479151
16mitotic sister chromatid segregation (GO:0000070)4.34054477
17chromatin assembly (GO:0031497)4.21987050
18DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.03955644
193-UTR-mediated mRNA stabilization (GO:0070935)3.96906689
20response to methylmercury (GO:0051597)3.86820053
21mitotic chromosome condensation (GO:0007076)3.83406884
22DNA topological change (GO:0006265)3.79127596
23regulation of histone H3-K9 methylation (GO:0051570)3.77409669
24negative regulation of histone methylation (GO:0031061)3.69235316
25DNA unwinding involved in DNA replication (GO:0006268)3.67642775
26erythrocyte development (GO:0048821)3.66814122
27positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.64818847
28positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.64818847
29positive regulation of mitotic sister chromatid separation (GO:1901970)3.64818847
30heme metabolic process (GO:0042168)3.62981309
31protein localization to kinetochore (GO:0034501)3.62413117
32pore complex assembly (GO:0046931)3.53513813
33negative regulation of erythrocyte differentiation (GO:0045647)3.46199915
34kinetochore organization (GO:0051383)3.45970941
35histone H3-K36 demethylation (GO:0070544)3.45472685
36Golgi transport vesicle coating (GO:0048200)3.43626978
37COPI coating of Golgi vesicle (GO:0048205)3.43626978
38positive regulation of chromosome segregation (GO:0051984)3.38937292
39regulation of centriole replication (GO:0046599)3.38796183
40response to insecticide (GO:0017085)3.37332993
41cellular protein complex localization (GO:0034629)3.36296565
42DNA damage response, signal transduction resulting in transcription (GO:0042772)3.36210135
43protein localization to chromosome, centromeric region (GO:0071459)3.35451052
44regulation of RNA export from nucleus (GO:0046831)3.35362155
45regulation of histone H3-K27 methylation (GO:0061085)3.31602711
46definitive hemopoiesis (GO:0060216)3.24466591
47microtubule depolymerization (GO:0007019)3.22574976
48embryonic process involved in female pregnancy (GO:0060136)3.20355668
49protein complex localization (GO:0031503)3.19723338
50regulation of sister chromatid cohesion (GO:0007063)3.19068987
51heterochromatin organization (GO:0070828)3.18584788
52L-alpha-amino acid transmembrane transport (GO:1902475)3.17777892
53nucleosome disassembly (GO:0006337)3.16503945
54protein-DNA complex disassembly (GO:0032986)3.16503945
55meiotic chromosome segregation (GO:0045132)3.15378124
56embryonic retina morphogenesis in camera-type eye (GO:0060059)3.15007710
57mitotic nuclear envelope disassembly (GO:0007077)3.14992428
58dosage compensation (GO:0007549)3.13679666
59response to lead ion (GO:0010288)3.12358590
60myeloid cell development (GO:0061515)3.11512758
61DNA replication-dependent nucleosome organization (GO:0034723)3.10450347
62DNA replication-dependent nucleosome assembly (GO:0006335)3.10450347
63folic acid-containing compound biosynthetic process (GO:0009396)3.10301511
64erythrocyte differentiation (GO:0030218)3.09423703
65* protein export from nucleus (GO:0006611)3.09217462
66cytoskeletal anchoring at plasma membrane (GO:0007016)3.06391135
67DNA replication initiation (GO:0006270)3.05033564
68positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.03756720
69chromatin assembly or disassembly (GO:0006333)3.03383443
70mRNA stabilization (GO:0048255)3.02341061
71RNA stabilization (GO:0043489)3.02341061
72membrane disassembly (GO:0030397)3.01149210
73nuclear envelope disassembly (GO:0051081)3.01149210
74nucleosome assembly (GO:0006334)2.99195258
75DNA duplex unwinding (GO:0032508)2.98802063
76DNA geometric change (GO:0032392)2.98630533
77nucleosome organization (GO:0034728)2.96274474
78spliceosomal tri-snRNP complex assembly (GO:0000244)2.96201977
79regulation of NFAT protein import into nucleus (GO:0051532)2.95493161
80bicarbonate transport (GO:0015701)2.95081516
81cellular hyperosmotic response (GO:0071474)2.93301505
82tetrapyrrole metabolic process (GO:0033013)2.92164009
83regulation of centrosome duplication (GO:0010824)2.90311234
84cytoplasmic mRNA processing body assembly (GO:0033962)2.89445358
85regulation of chromatin binding (GO:0035561)2.87995657
86chromosome condensation (GO:0030261)2.87726115
87peptidyl-threonine phosphorylation (GO:0018107)2.84174469
88regulation of stem cell maintenance (GO:2000036)2.83816685
89protein targeting to plasma membrane (GO:0072661)2.82752584
90intracellular estrogen receptor signaling pathway (GO:0030520)2.81441412
91peptidyl-threonine modification (GO:0018210)2.81029382
92regulation of early endosome to late endosome transport (GO:2000641)2.79904527
93regulation of centrosome cycle (GO:0046605)2.79099039
94regulation of DNA damage checkpoint (GO:2000001)2.76886603
95DNA conformation change (GO:0071103)2.75714666
96very-low-density lipoprotein particle assembly (GO:0034379)2.75209336
97regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.73935859
98proline biosynthetic process (GO:0006561)2.73336928
99regulation of response to osmotic stress (GO:0047484)2.73057760
100kinetochore assembly (GO:0051382)2.72589179
101negative regulation of DNA-dependent DNA replication (GO:2000104)2.72466577
102regulation of nucleobase-containing compound transport (GO:0032239)2.71764175
103iron ion import (GO:0097286)2.70038483
104adherens junction assembly (GO:0034333)2.69812291
105regulation of mitotic spindle organization (GO:0060236)2.69382685
106paraxial mesoderm development (GO:0048339)2.68664692
107DNA synthesis involved in DNA repair (GO:0000731)2.67960797
108cell-substrate adherens junction assembly (GO:0007045)2.67649669
109focal adhesion assembly (GO:0048041)2.67649669
110hematopoietic stem cell differentiation (GO:0060218)2.67271006
111NLS-bearing protein import into nucleus (GO:0006607)2.67211257
112regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.66738293
113negative regulation of DNA repair (GO:0045738)2.66584504
114response to arsenic-containing substance (GO:0046685)2.66525711
115histone lysine demethylation (GO:0070076)2.66154879
116nuclear envelope organization (GO:0006998)2.65181943
117regulation of spindle organization (GO:0090224)2.63259775
118protein localization to chromosome (GO:0034502)2.61960362
119actin filament capping (GO:0051693)2.61449004
120DNA strand elongation involved in DNA replication (GO:0006271)2.61080406
121regulation of telomere maintenance via telomerase (GO:0032210)2.60157503
122translesion synthesis (GO:0019985)2.59804493
123negative regulation of histone modification (GO:0031057)2.58535936
124retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.58217591
125response to epidermal growth factor (GO:0070849)2.57369180
126pentose-phosphate shunt (GO:0006098)2.57026918
127DNA strand elongation (GO:0022616)2.56804923
128megakaryocyte development (GO:0035855)2.56766383
129DNA strand renaturation (GO:0000733)2.56609052
130glucocorticoid receptor signaling pathway (GO:0042921)2.55790129
131histone H3-K9 demethylation (GO:0033169)2.55132616
132gene silencing by RNA (GO:0031047)2.53281802
133histone H3-K4 methylation (GO:0051568)2.53224273
134positive regulation of fibroblast migration (GO:0010763)2.52975191
135N-terminal protein amino acid acetylation (GO:0006474)2.50411099
136regulation of translational fidelity (GO:0006450)2.50159785
137gene silencing (GO:0016458)2.49799720
138regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.49666401
139DNA packaging (GO:0006323)2.49345522
140regulation of histone methylation (GO:0031060)2.49340929
141protein-DNA complex subunit organization (GO:0071824)2.47483983
142regulation of histone H3-K4 methylation (GO:0051569)2.47417265
143response to UV-C (GO:0010225)2.46659264
144negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.45894410
145histone demethylation (GO:0016577)2.45730242
146regulation of mammary gland epithelial cell proliferation (GO:0033599)2.45706117
147protein K6-linked ubiquitination (GO:0085020)2.45635220
148regulation of mRNA stability (GO:0043488)2.45518818
149chromosome segregation (GO:0007059)2.44455775
150attachment of spindle microtubules to kinetochore (GO:0008608)2.43868308
151protoporphyrinogen IX metabolic process (GO:0046501)10.6413754

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human7.49676703
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.51959163
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.07256631
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.52720670
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.06869382
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.87270678
7GATA1_19941826_ChIP-Seq_K562_Human2.84131677
8GATA1_22025678_ChIP-Seq_K562_Human2.63874520
9TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.60539896
10HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.60378239
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.59652443
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.32875253
13KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse2.26738529
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.25436896
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.19901771
16SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.15755485
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.10756730
18* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.10619811
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.07628402
20MYC_22102868_ChIP-Seq_BL_Human2.04298088
21ESR1_15608294_ChIP-ChIP_MCF-7_Human2.01700493
22E2F7_22180533_ChIP-Seq_HELA_Human10.9538727
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.99010368
24* GATA1_19941827_ChIP-Seq_MEL_Mouse1.96343788
25MYC_18555785_ChIP-Seq_MESCs_Mouse1.90086781
26AR_21909140_ChIP-Seq_LNCAP_Human1.78399187
27TP63_19390658_ChIP-ChIP_HaCaT_Human1.77023417
28* CLOCK_20551151_ChIP-Seq_293T_Human1.73491335
29VDR_21846776_ChIP-Seq_THP-1_Human1.66099931
30CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.65772142
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.65768318
32WT1_19549856_ChIP-ChIP_CCG9911_Human1.64615266
33EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.59577649
34* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59376053
35FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.56151579
36KLF4_18555785_ChIP-Seq_MESCs_Mouse1.55834701
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54447236
38CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.54308953
39* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.52777144
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.52351567
41GATA2_19941826_ChIP-Seq_K562_Human1.50512539
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.48769593
43SOX2_16153702_ChIP-ChIP_HESCs_Human1.44007918
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42344464
45BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38366276
46SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.37849861
47SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.36190882
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33974534
49SCL_19346495_ChIP-Seq_HPC-7_Human1.32936476
50* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.32870251
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.32544290
52TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32226999
53DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30823477
54SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.30495574
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29558942
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.29500938
57* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27059894
58TFEB_21752829_ChIP-Seq_HELA_Human1.26158695
59TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25725970
60MYB_21317192_ChIP-Seq_ERMYB_Mouse1.25596354
61XRN2_22483619_ChIP-Seq_HELA_Human1.25588915
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23651151
63* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22958984
64DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22766292
65TCF7_22412390_ChIP-Seq_EML_Mouse1.20653269
66KDM2B_26808549_Chip-Seq_K562_Human1.20534342
67PKCTHETA_26484144_Chip-Seq_BREAST_Human1.18162123
68KDM2B_26808549_Chip-Seq_DND41_Human1.17433740
69RACK7_27058665_Chip-Seq_MCF-7_Human1.15701633
70NCOR1_26117541_ChIP-Seq_K562_Human1.09970567
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09004498
72NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06831692
73KDM2B_26808549_Chip-Seq_JURKAT_Human1.04165205
74BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04064893
75ZNF263_19887448_ChIP-Seq_K562_Human1.03681959
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03511662
77RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03500739
78TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03287229
79ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.02488239
80* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.02206713
81TBX3_20139965_ChIP-Seq_MESCs_Mouse1.00959119
82GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.00674344
83EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00084548
84POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99577228
85TP53_16413492_ChIP-PET_HCT116_Human0.98893085
86STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98713412
87MAF_26560356_Chip-Seq_TH1_Human0.97970390
88TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97697878
89KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97091913
90TCF3_18692474_ChIP-Seq_MESCs_Mouse0.97013344
91NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96157442
92ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96128936
93CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95967610
94NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95771221
95ATF3_27146783_Chip-Seq_COLON_Human0.95498167
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93899905
97RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93807000
98NANOG_21062744_ChIP-ChIP_HESCs_Human0.93192895
99KDM5A_27292631_Chip-Seq_BREAST_Human0.91311347
100CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90882701
101GATA6_25053715_ChIP-Seq_YYC3_Human0.90421452
102SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89601423
103TP63_17297297_ChIP-ChIP_HaCaT_Human0.89472368
104SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89405396
105LXR_22292898_ChIP-Seq_THP-1_Human0.88638273
106SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87747115
107KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87402713
108ISL1_27105846_Chip-Seq_CPCs_Mouse0.87178963
109* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86331771
110FOXA2_19822575_ChIP-Seq_HepG2_Human0.84317010
111NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.84291560
112PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.84031215
113POU5F1_16153702_ChIP-ChIP_HESCs_Human0.82835114
114GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.82630041
115* MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.82510982
116YAP1_20516196_ChIP-Seq_MESCs_Mouse0.81427248
117POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.81027630
118* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.80884224
119CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.80749200
120P300_27058665_Chip-Seq_ZR-75-30cells_Human0.80143469
121* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78322061
122ZFP281_18757296_ChIP-ChIP_E14_Mouse0.77319239
123ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.75833560
124KDM2B_26808549_Chip-Seq_SUP-B15_Human0.73936783
125RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.73144443
126CHD1_26751641_Chip-Seq_LNCaP_Human0.72643104
127STAT6_21828071_ChIP-Seq_BEAS2B_Human0.71662608
128TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.70692312
129* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.70513480
130AR_19668381_ChIP-Seq_PC3_Human0.70317278
131FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.69729529
132TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.68695633
133STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.68101341
134PADI4_21655091_ChIP-ChIP_MCF-7_Human0.66545734
135NANOG_16153702_ChIP-ChIP_HESCs_Human0.66362275
136KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.66323354
137CIITA_25753668_ChIP-Seq_RAJI_Human0.65344342
138ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.65010763
139SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64447096
140* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.64021061
141UTX_26944678_Chip-Seq_JUKART_Human0.62379792
142ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.60377443
143CREB1_26743006_Chip-Seq_LNCaP_Human0.59947000
144WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.58856250
145STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.58739808
146CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.58208620
147TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.57847329

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo6.90215269
2MP0004147_increased_porphyrin_level5.22387308
3MP0003111_abnormal_nucleus_morphology4.30165740
4MP0010094_abnormal_chromosome_stability3.32591731
5MP0005076_abnormal_cell_differentiation2.69743935
6MP0010307_abnormal_tumor_latency2.53717801
7MP0003077_abnormal_cell_cycle2.51760760
8MP0003121_genomic_imprinting2.48967070
9MP0003787_abnormal_imprinting2.45991462
10MP0005451_abnormal_body_composition2.41746929
11MP0005083_abnormal_biliary_tract2.41391888
12MP0008057_abnormal_DNA_replication2.40744451
13MP0003123_paternal_imprinting2.35717251
14MP0003705_abnormal_hypodermis_morpholog2.32274934
15MP0008260_abnormal_autophagy2.21161389
16MP0009053_abnormal_anal_canal2.12910963
17MP0003890_abnormal_embryonic-extraembry1.99257384
18MP0008877_abnormal_DNA_methylation1.94051284
19MP0003693_abnormal_embryo_hatching1.90901184
20MP0004197_abnormal_fetal_growth/weight/1.82124338
21MP0000350_abnormal_cell_proliferation1.74933275
22MP0010352_gastrointestinal_tract_polyps1.69210786
23MP0010030_abnormal_orbit_morphology1.68473418
24MP0008058_abnormal_DNA_repair1.66374472
25MP0009703_decreased_birth_body1.66262512
26MP0009278_abnormal_bone_marrow1.66095512
27MP0002086_abnormal_extraembryonic_tissu1.65946125
28MP0005380_embryogenesis_phenotype1.65139280
29MP0001672_abnormal_embryogenesis/_devel1.65139280
30MP0009672_abnormal_birth_weight1.63944513
31MP0002084_abnormal_developmental_patter1.62354899
32MP0000569_abnormal_digit_pigmentation1.61390603
33MP0005409_darkened_coat_color1.60982754
34MP0004233_abnormal_muscle_weight1.59083365
35MP0004957_abnormal_blastocyst_morpholog1.52105480
36MP0003122_maternal_imprinting1.46390636
37MP0001915_intracranial_hemorrhage1.46305749
38MP0002088_abnormal_embryonic_growth/wei1.45622171
39MP0003283_abnormal_digestive_organ1.45557355
40MP0003984_embryonic_growth_retardation1.45209726
41MP0001730_embryonic_growth_arrest1.43434798
42MP0004264_abnormal_extraembryonic_tissu1.42692555
43MP0003221_abnormal_cardiomyocyte_apopto1.42087442
44MP0002085_abnormal_embryonic_tissue1.40058152
45MP0008770_decreased_survivor_rate1.40033341
46MP0003252_abnormal_bile_duct1.36974100
47MP0008438_abnormal_cutaneous_collagen1.34792314
48MP0003453_abnormal_keratinocyte_physiol1.31244569
49MP0001697_abnormal_embryo_size1.30492565
50MP0003119_abnormal_digestive_system1.30027177
51MP0005248_abnormal_Harderian_gland1.26135135
52MP0002139_abnormal_hepatobiliary_system1.23054924
53MP0002080_prenatal_lethality1.16751493
54MP0000537_abnormal_urethra_morphology1.15367825
55MP0010630_abnormal_cardiac_muscle1.14211452
56MP0005666_abnormal_adipose_tissue1.12566282
57MP0005085_abnormal_gallbladder_physiolo1.12549339
58MP0005187_abnormal_penis_morphology1.10146946
59MP0001661_extended_life_span1.09512074
60MP0003091_abnormal_cell_migration1.08457016
61MP0003567_abnormal_fetal_cardiomyocyte1.05544313
62MP0004185_abnormal_adipocyte_glucose1.04593639
63MP0002697_abnormal_eye_size1.04507648
64MP0003300_gastrointestinal_ulcer1.02204683
65MP0004808_abnormal_hematopoietic_stem1.00846288
66MP0003861_abnormal_nervous_system1.00583124
67MP0003937_abnormal_limbs/digits/tail_de1.00039069
68MP0010234_abnormal_vibrissa_follicle0.99910294
69MP0008961_abnormal_basal_metabolism0.98845814
70MP0001293_anophthalmia0.98595948
71MP0005623_abnormal_meninges_morphology0.98358064
72MP0003935_abnormal_craniofacial_develop0.97777854
73MP0000383_abnormal_hair_follicle0.97487831
74MP0003115_abnormal_respiratory_system0.96405739
75MP0010678_abnormal_skin_adnexa0.93498224
76MP0002092_abnormal_eye_morphology0.92762271
77MP0002396_abnormal_hematopoietic_system0.92220271
78MP0009697_abnormal_copulation0.91754902
79MP0003566_abnormal_cell_adhesion0.91711956
80MP0009931_abnormal_skin_appearance0.91264421
81MP0004272_abnormal_basement_membrane0.90791502
82MP0002877_abnormal_melanocyte_morpholog0.90275256
83MP0000747_muscle_weakness0.90204350
84MP0002060_abnormal_skin_morphology0.89352262
85MP0005360_urolithiasis0.87634058
86MP0003868_abnormal_feces_composition0.87515569
87MP0002653_abnormal_ependyma_morphology0.84670773
88MP0005501_abnormal_skin_physiology0.84155474
89MP0000428_abnormal_craniofacial_morphol0.84066176
90MP0000579_abnormal_nail_morphology0.83790409
91MP0000733_abnormal_muscle_development0.83445500
92MP0004087_abnormal_muscle_fiber0.82870324
93MP0000490_abnormal_crypts_of0.82672022
94MP0005365_abnormal_bile_salt0.82255324
95MP0000313_abnormal_cell_death0.82094153
96MP0005464_abnormal_platelet_physiology0.81454034
97MP0002166_altered_tumor_susceptibility0.81012146
98MP0005397_hematopoietic_system_phenotyp0.79998212
99MP0001545_abnormal_hematopoietic_system0.79998212
100MP0000566_synostosis0.79912677
101MP0005375_adipose_tissue_phenotype0.79609748
102MP0008932_abnormal_embryonic_tissue0.79409346
103MP0001286_abnormal_eye_development0.78621641
104MP0000266_abnormal_heart_morphology0.78382081
105MP0002111_abnormal_tail_morphology0.77857138
106MP0005394_taste/olfaction_phenotype0.77679791
107MP0005499_abnormal_olfactory_system0.77679791
108MP0002925_abnormal_cardiovascular_devel0.77406517
109MP0000759_abnormal_skeletal_muscle0.76901277
110MP0000003_abnormal_adipose_tissue0.75293063
111MP0004858_abnormal_nervous_system0.75092363
112MP0001849_ear_inflammation0.74046625
113MP0002009_preneoplasia0.73943498
114MP0002234_abnormal_pharynx_morphology0.73427309
115MP0003172_abnormal_lysosome_physiology0.73396685
116MP0003941_abnormal_skin_development0.72391636
117MP0005621_abnormal_cell_physiology0.72166640
118MP0000432_abnormal_head_morphology0.72151804
119MP0006138_congestive_heart_failure0.71974309
120MP0004859_abnormal_synaptic_plasticity0.71587281
121MP0008007_abnormal_cellular_replicative0.71319000
122MP0003943_abnormal_hepatobiliary_system0.70496715
123MP0002928_abnormal_bile_duct0.69160583
124MP0002019_abnormal_tumor_incidence0.68540839
125MP0008995_early_reproductive_senescence0.67545894
126MP0003385_abnormal_body_wall0.66362243
127MP0000703_abnormal_thymus_morphology0.65975344
128MP0001299_abnormal_eye_distance/0.65867416
129MP0005384_cellular_phenotype0.65504936
130MP0001784_abnormal_fluid_regulation0.63983560
131MP0006292_abnormal_olfactory_placode0.63681803
132MP0001346_abnormal_lacrimal_gland0.62003393
133MP0002796_impaired_skin_barrier0.61820178
134MP0000377_abnormal_hair_follicle0.61521492
135MP0003329_amyloid_beta_deposits0.60196768

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)8.56167104
2Hypochromic microcytic anemia (HP:0004840)8.38159981
3Abnormality of the heme biosynthetic pathway (HP:0010472)6.09391966
4Acanthocytosis (HP:0001927)5.54472378
5Reticulocytosis (HP:0001923)5.04595809
6Osteomalacia (HP:0002749)4.56378923
7Insomnia (HP:0100785)4.16650989
8Cholelithiasis (HP:0001081)3.81385224
9Hypochromic anemia (HP:0001931)3.50355723
10Abnormal gallbladder morphology (HP:0012437)3.29270960
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.28193169
12Abnormality of reticulocytes (HP:0004312)3.23842728
13Chromsome breakage (HP:0040012)3.12312129
14Cholecystitis (HP:0001082)3.07421785
15Abnormal gallbladder physiology (HP:0012438)3.07421785
16Polycythemia (HP:0001901)2.97860682
17Volvulus (HP:0002580)2.84357097
18Abnormality of the fingertips (HP:0001211)2.71277142
19Abnormality of the labia minora (HP:0012880)2.69136798
20Heterotopia (HP:0002282)2.68281389
21Abnormal hemoglobin (HP:0011902)2.68205777
22Increased nuchal translucency (HP:0010880)2.65207929
23Paralysis (HP:0003470)2.62705389
24Diaphragmatic weakness (HP:0009113)2.59885515
25Dysmetric saccades (HP:0000641)2.56607935
26Short 4th metacarpal (HP:0010044)2.51324145
27Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.51324145
28Hyperbilirubinemia (HP:0002904)2.49863741
29Elfin facies (HP:0004428)2.46477912
30Renovascular hypertension (HP:0100817)2.43906719
31Ependymoma (HP:0002888)2.39619423
32Abnormality of the gallbladder (HP:0005264)2.37642553
33Asymmetry of the thorax (HP:0001555)2.35679456
34Obsessive-compulsive behavior (HP:0000722)2.33267332
35Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.32879067
36Orthostatic hypotension (HP:0001278)2.29252171
37Insidious onset (HP:0003587)2.28586909
38Termporal pattern (HP:0011008)2.28586909
39Renal duplication (HP:0000075)2.25497252
40Uterine leiomyosarcoma (HP:0002891)2.24882456
41Leiomyosarcoma (HP:0100243)2.24882456
42Macroorchidism (HP:0000053)2.24034174
43Hyperacusis (HP:0010780)2.23738453
44Ectopic kidney (HP:0000086)2.21245398
45Long eyelashes (HP:0000527)2.20815894
46Astrocytoma (HP:0009592)2.18097882
47Abnormality of the astrocytes (HP:0100707)2.18097882
48Relative macrocephaly (HP:0004482)2.13427085
49Disproportionate tall stature (HP:0001519)2.12018495
50Broad palm (HP:0001169)2.08302086
51Increased connective tissue (HP:0009025)2.07673450
52Skull defect (HP:0001362)2.07129738
53Abnormality of oral frenula (HP:0000190)2.06608740
54Hepatocellular carcinoma (HP:0001402)2.05105893
55Germ cell neoplasia (HP:0100728)2.03499559
56Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.01765426
57Bowel incontinence (HP:0002607)2.01123396
58Ileus (HP:0002595)2.00539642
59Osteolytic defects of the hand bones (HP:0009699)1.98384704
60Osteolytic defects of the phalanges of the hand (HP:0009771)1.98384704
61Medulloblastoma (HP:0002885)1.97261378
62Truncal obesity (HP:0001956)1.96854625
63Prominent nose (HP:0000448)1.94189859
64Distal lower limb amyotrophy (HP:0008944)1.92992009
65Pseudobulbar signs (HP:0002200)1.91824514
66Long palpebral fissure (HP:0000637)1.91299295
67Abnormality of the 4th metacarpal (HP:0010012)1.91181836
68Abnormal large intestine physiology (HP:0012700)1.91008951
69Anal stenosis (HP:0002025)1.90640800
70Metaphyseal cupping (HP:0003021)1.90331962
71Cafe-au-lait spot (HP:0000957)1.89258051
72Trigonocephaly (HP:0000243)1.89140016
73Abnormality of chromosome stability (HP:0003220)1.88994800
74Abnormality of chromosome segregation (HP:0002916)1.88949202
75Decreased motor nerve conduction velocity (HP:0003431)1.88490805
76Microcytic anemia (HP:0001935)1.88432405
77Renal cell carcinoma (HP:0005584)1.88238896
78Impulsivity (HP:0100710)1.86206495
79Glioma (HP:0009733)1.85411038
80Hammertoe (HP:0001765)1.85331997
81Basal cell carcinoma (HP:0002671)1.84942335
82Rhabdomyosarcoma (HP:0002859)1.84753871
83Shallow orbits (HP:0000586)1.84378728
84High anterior hairline (HP:0009890)1.83107792
85Mesomelia (HP:0003027)1.82914126
86Abnormality of the calcaneus (HP:0008364)1.82883887
87Neoplasm of striated muscle (HP:0009728)1.82638948
88Sacral dimple (HP:0000960)1.82414317
89Abnormal number of incisors (HP:0011064)1.81953709
90Obstructive sleep apnea (HP:0002870)1.80794301
91Abnormality of the carotid arteries (HP:0005344)1.80182524
92Increased mean platelet volume (HP:0011877)1.79912953
93Abnormality of the diencephalon (HP:0010662)1.78127452
94Neoplasm of the oral cavity (HP:0100649)1.77751340
95Ulnar bowing (HP:0003031)1.77269228
96Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.77202033
97Smooth philtrum (HP:0000319)1.76951184
98High pitched voice (HP:0001620)1.72784034
99Overlapping toe (HP:0001845)1.72458480
100Aplasia/Hypoplasia of the sternum (HP:0006714)1.72210197
101Aplasia/Hypoplasia of the uvula (HP:0010293)1.70805108
102Acute myeloid leukemia (HP:0004808)1.70775347
103Facial hemangioma (HP:0000329)1.70622004
104Biliary tract neoplasm (HP:0100574)1.69799959
105Centrally nucleated skeletal muscle fibers (HP:0003687)1.68548529
106Overriding aorta (HP:0002623)1.67914670
107Spastic diplegia (HP:0001264)1.67750120
108Vertebral arch anomaly (HP:0008438)1.67657847
109Autoamputation (HP:0001218)1.67502186
110Confusion (HP:0001289)1.67258359
111Peripheral hypomyelination (HP:0007182)1.66626322
112Birth length less than 3rd percentile (HP:0003561)1.66207886
113Abnormal platelet volume (HP:0011876)1.65715924
114Deep philtrum (HP:0002002)1.65219990
115Abnormality of the salivary glands (HP:0010286)1.64439613
116Malignant gastrointestinal tract tumors (HP:0006749)1.64368118
117Gastrointestinal carcinoma (HP:0002672)1.64368118
118Pointed chin (HP:0000307)1.63056650
119Lower limb amyotrophy (HP:0007210)1.62735458
120Transitional cell carcinoma of the bladder (HP:0006740)1.62528916
121Hypoparathyroidism (HP:0000829)1.62343730
122Protrusio acetabuli (HP:0003179)1.61758668
123Subacute progressive viral hepatitis (HP:0006572)1.61705342
124Back pain (HP:0003418)1.61637209
125Oligodactyly (hands) (HP:0001180)1.60224085
126Abnormality of the thoracic spine (HP:0100711)1.59190588
127Truncus arteriosus (HP:0001660)1.59161638
128Meckel diverticulum (HP:0002245)1.59001028
129Hypoplastic labia majora (HP:0000059)1.58984627
130Cerebral aneurysm (HP:0004944)1.58621678
131Abnormality of the distal phalanx of the thumb (HP:0009617)1.58410745
132Neoplasm of the liver (HP:0002896)1.57753266
133Ankyloglossia (HP:0010296)1.57598296
134Cortical dysplasia (HP:0002539)1.57262063
135Oligodactyly (HP:0012165)1.56836239
136Bladder neoplasm (HP:0009725)1.55773616
137Bladder carcinoma (HP:0002862)1.55773616
138Sandal gap (HP:0001852)1.55737926
139Deep palmar crease (HP:0006191)1.54786512
140Hypopigmentation of the fundus (HP:0007894)1.54046115
141Pelvic girdle muscle weakness (HP:0003749)1.53999977
142Blepharophimosis (HP:0000581)1.53982099
143Rectal prolapse (HP:0002035)1.52472592
144Proximal placement of thumb (HP:0009623)1.51736294
145Papillary thyroid carcinoma (HP:0002895)1.51579156
146Syringomyelia (HP:0003396)1.51511519
147Spinal cord lesions (HP:0100561)1.51511519
148Wormian bones (HP:0002645)1.51376775
149Broad thumb (HP:0011304)1.51329397
150Overgrowth (HP:0001548)1.51079589
151Duodenal stenosis (HP:0100867)1.51012594
152Small intestinal stenosis (HP:0012848)1.51012594
153Cutaneous photosensitivity (HP:0000992)1.50797395
154Thyroid carcinoma (HP:0002890)1.49967873
155Enlarged penis (HP:0000040)1.48242275
156Deviation of the thumb (HP:0009603)1.48087197
157Abnormality of pyrimidine metabolism (HP:0004353)1.47181772
158Abnormality of the ileum (HP:0001549)1.47142977
159Attention deficit hyperactivity disorder (HP:0007018)1.46969326
160Cutis marmorata (HP:0000965)1.46584993

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.71073299
2CDC73.71170294
3PRPF4B3.25887629
4EEF2K2.98565546
5SMG12.88069539
6EIF2AK12.84576249
7BRD42.62111843
8LATS12.58534812
9TLK12.52915655
10MAP3K102.42849290
11NEK22.29829217
12PKN22.29059027
13STK42.13463188
14KSR22.05721450
15CAMK1D2.00158197
16ZAK1.79144959
17TTK1.74447587
18MAP2K31.72424472
19CDK61.71496571
20CAMK1G1.66158984
21CDK41.60400650
22TAOK21.58699584
23WNK11.54942025
24NEK11.48488441
25STK101.47349363
26CDK91.44085457
27STK31.42982142
28ALK1.36851400
29CHEK21.32447768
30TRIB31.31433002
31CHEK11.31061645
32FGFR41.28873745
33SCYL21.24967182
34CLK11.23930383
35ATR1.23416742
36DYRK31.21929170
37ERBB21.20258242
38BRSK11.17641256
39MELK1.17268283
40SGK31.16751729
41MAP3K81.15172047
42ATM1.14909247
43TTN1.13807284
44MTOR1.13075119
45PDGFRA1.11883676
46AURKB1.09337211
47FLT31.07383500
48RPS6KB21.05483882
49NTRK11.04629840
50MAP3K61.02762632
51PTK61.01225520
52PLK10.99949638
53MAPK110.99191219
54BMX0.95263541
55CDC42BPA0.94916659
56ICK0.93965679
57SIK20.93933883
58SIK10.91305744
59IRAK30.91044316
60NTRK30.90150265
61CDK20.89562051
62AKT30.89554324
63BRAF0.89141154
64CSNK1D0.87225719
65MAP3K20.86918397
66RIPK10.86478509
67EPHA20.85477364
68CDK70.84210508
69SGK20.83878995
70AKT20.83508811
71CDK10.83033478
72PIM10.82452812
73PRKAA10.82103308
74GRK60.81441554
75MAP3K10.79205965
76RIPK40.79070452
77MAP3K40.76650371
78YES10.76095209
79MAP3K130.76078054
80RAF10.73868324
81SGK10.73413344
82MARK20.73397412
83FGFR10.70445454
84TSSK60.70303068
85PBK0.69205237
86SGK2230.68198696
87SGK4940.68198696
88PLK30.67466031
89MAP3K70.67173864
90TRPM70.67165651
91PRKDC0.67135371
92MAPK140.66667727
93TYRO30.66095446
94INSRR0.60192775
95PAK40.58679132
96KSR10.58347523
97MAP3K30.58189014
98DMPK0.57168679
99AKT10.56737805
100SRPK10.56654782
101GSK3B0.56438030
102RET0.55039919
103NEK90.54404973
104RPS6KA50.53804739
105LATS20.52300630
106MKNK20.51112848
107AURKA0.50888889
108PNCK0.50160883
109MET0.49892307
110MAP3K50.49585395
111EIF2AK20.48995478
112TAF10.48729889
113CSNK1E0.48022737
114DAPK20.46799546
115RPS6KC10.46703006
116RPS6KL10.46703006
117PRKAA20.46030431
118MAPK100.45884372
119MAP2K40.43921277
120TAOK10.43540331
121WEE10.42880230
122RPS6KA20.42569095
123TAOK30.42389960
124PASK0.42259847
125RPS6KA30.41397518
126PDGFRB0.41154027
127FGFR30.41105880
128JAK20.41036910
129STK110.40208959
130PLK40.39963115
131MAP2K10.38351515
132MAPK80.37922696
133PTK20.36019135
134DYRK1B0.35308138
135PRKCB0.34743895
136NUAK10.34132624
137MAPK10.33991182
138RPS6KB10.30674958
139HIPK20.30401521

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053224.15741708
2Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.27542793
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.07579660
4Vitamin B6 metabolism_Homo sapiens_hsa007502.65957030
5One carbon pool by folate_Homo sapiens_hsa006702.39222100
6Alcoholism_Homo sapiens_hsa050342.39187738
7Cell cycle_Homo sapiens_hsa041102.35367286
8Lysine degradation_Homo sapiens_hsa003102.30239947
9Nitrogen metabolism_Homo sapiens_hsa009102.12251593
10mRNA surveillance pathway_Homo sapiens_hsa030151.72462997
11Renal cell carcinoma_Homo sapiens_hsa052111.68736445
12Non-small cell lung cancer_Homo sapiens_hsa052231.63677022
13Chronic myeloid leukemia_Homo sapiens_hsa052201.55104497
14Viral carcinogenesis_Homo sapiens_hsa052031.52449613
15Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.48312734
16MicroRNAs in cancer_Homo sapiens_hsa052061.47900954
17Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.45146255
18Fanconi anemia pathway_Homo sapiens_hsa034601.44400350
19Bladder cancer_Homo sapiens_hsa052191.44202020
20Dorso-ventral axis formation_Homo sapiens_hsa043201.43040046
21Glioma_Homo sapiens_hsa052141.31292851
22Small cell lung cancer_Homo sapiens_hsa052221.26226429
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.26031212
24Basal cell carcinoma_Homo sapiens_hsa052171.24149388
25Biosynthesis of amino acids_Homo sapiens_hsa012301.19514607
26Selenocompound metabolism_Homo sapiens_hsa004501.18344644
27mTOR signaling pathway_Homo sapiens_hsa041501.18201167
28VEGF signaling pathway_Homo sapiens_hsa043701.17603125
29Endometrial cancer_Homo sapiens_hsa052131.14030682
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.12213765
31RNA transport_Homo sapiens_hsa030131.11359238
32Oocyte meiosis_Homo sapiens_hsa041141.09970746
33ABC transporters_Homo sapiens_hsa020101.09757458
34DNA replication_Homo sapiens_hsa030301.09477118
35Pentose phosphate pathway_Homo sapiens_hsa000301.09463456
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07036749
37Prostate cancer_Homo sapiens_hsa052151.06020955
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04921842
39Type II diabetes mellitus_Homo sapiens_hsa049301.02511331
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00272246
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.99987039
42Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99368166
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99291494
44p53 signaling pathway_Homo sapiens_hsa041150.98810022
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98583630
46Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97645503
47Pancreatic cancer_Homo sapiens_hsa052120.96796787
48HIF-1 signaling pathway_Homo sapiens_hsa040660.96343097
49Longevity regulating pathway - mammal_Homo sapiens_hsa042110.94426528
50Arginine biosynthesis_Homo sapiens_hsa002200.93683755
51Adherens junction_Homo sapiens_hsa045200.93545385
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.92855820
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92048953
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89875018
55AMPK signaling pathway_Homo sapiens_hsa041520.89711549
56Hippo signaling pathway_Homo sapiens_hsa043900.88531143
57FoxO signaling pathway_Homo sapiens_hsa040680.85681269
58Mismatch repair_Homo sapiens_hsa034300.83890960
59Melanoma_Homo sapiens_hsa052180.83220271
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82398571
61Bile secretion_Homo sapiens_hsa049760.81150134
62Hedgehog signaling pathway_Homo sapiens_hsa043400.81046734
63HTLV-I infection_Homo sapiens_hsa051660.80040496
64B cell receptor signaling pathway_Homo sapiens_hsa046620.77899202
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.77644696
66GnRH signaling pathway_Homo sapiens_hsa049120.76787207
67Thyroid cancer_Homo sapiens_hsa052160.76263562
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.76200028
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74524475
70Carbon metabolism_Homo sapiens_hsa012000.73767133
71Glucagon signaling pathway_Homo sapiens_hsa049220.72008475
72Prion diseases_Homo sapiens_hsa050200.69809088
73Proteoglycans in cancer_Homo sapiens_hsa052050.69497830
74Wnt signaling pathway_Homo sapiens_hsa043100.68946783
75Insulin resistance_Homo sapiens_hsa049310.68587471
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66798803
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65713315
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65512142
79Insulin signaling pathway_Homo sapiens_hsa049100.65342135
80Colorectal cancer_Homo sapiens_hsa052100.65195847
81Non-homologous end-joining_Homo sapiens_hsa034500.63356644
82Hepatitis C_Homo sapiens_hsa051600.63105416
83ErbB signaling pathway_Homo sapiens_hsa040120.63005253
84Long-term potentiation_Homo sapiens_hsa047200.60150379
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.59523934
86Complement and coagulation cascades_Homo sapiens_hsa046100.59049618
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58990891
88Amoebiasis_Homo sapiens_hsa051460.58716938
89Estrogen signaling pathway_Homo sapiens_hsa049150.57463697
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.56625438
91Herpes simplex infection_Homo sapiens_hsa051680.55903466
92Notch signaling pathway_Homo sapiens_hsa043300.55867296
93TGF-beta signaling pathway_Homo sapiens_hsa043500.55188318
94ECM-receptor interaction_Homo sapiens_hsa045120.54497148
95Fructose and mannose metabolism_Homo sapiens_hsa000510.54013409
96Tryptophan metabolism_Homo sapiens_hsa003800.52162279
97Inositol phosphate metabolism_Homo sapiens_hsa005620.52121198
98Hepatitis B_Homo sapiens_hsa051610.51584396
99Melanogenesis_Homo sapiens_hsa049160.51578849
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51531762
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51309489
102Platelet activation_Homo sapiens_hsa046110.50612498
103Rap1 signaling pathway_Homo sapiens_hsa040150.49748513
104Tight junction_Homo sapiens_hsa045300.49295680
105Pathways in cancer_Homo sapiens_hsa052000.49234468
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49040227
107Homologous recombination_Homo sapiens_hsa034400.48895296
108Choline metabolism in cancer_Homo sapiens_hsa052310.48435841
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48289964
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.47507308
111Malaria_Homo sapiens_hsa051440.47408647
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.47143209
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44797921
114Spliceosome_Homo sapiens_hsa030400.44564241
115Prolactin signaling pathway_Homo sapiens_hsa049170.44002851
116Olfactory transduction_Homo sapiens_hsa047400.43387461
117Gap junction_Homo sapiens_hsa045400.42514638
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41738694
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.39453816
120Nucleotide excision repair_Homo sapiens_hsa034200.39030397
121Axon guidance_Homo sapiens_hsa043600.38324240
122Acute myeloid leukemia_Homo sapiens_hsa052210.38024253
123Apoptosis_Homo sapiens_hsa042100.36163989
124Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.36108937
125Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35114351
126MAPK signaling pathway_Homo sapiens_hsa040100.34964519
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33893253
128Focal adhesion_Homo sapiens_hsa045100.33841725
129Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32669329
130Base excision repair_Homo sapiens_hsa034100.31862629
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31113482
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.30005043
133Insulin secretion_Homo sapiens_hsa049110.28952056

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »