XPOT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1folic acid-containing compound biosynthetic process (GO:0009396)5.73452848
2nuclear pore organization (GO:0006999)5.62024305
3nuclear pore complex assembly (GO:0051292)5.46731324
4regulation of translational fidelity (GO:0006450)5.08839157
5regulation of translational termination (GO:0006449)4.64149385
6protein localization to kinetochore (GO:0034501)4.51376806
7DNA unwinding involved in DNA replication (GO:0006268)4.44268426
8IMP biosynthetic process (GO:0006188)4.34060432
9glycine metabolic process (GO:0006544)4.32186897
10mitotic nuclear envelope disassembly (GO:0007077)4.26912304
11nucleobase biosynthetic process (GO:0046112)4.25055509
12tetrahydrofolate metabolic process (GO:0046653)4.20481346
13folic acid metabolic process (GO:0046655)4.16348862
14nuclear envelope disassembly (GO:0051081)4.10110667
15membrane disassembly (GO:0030397)4.10110667
16L-serine metabolic process (GO:0006563)4.07480714
17heterochromatin organization (GO:0070828)4.00141946
18pore complex assembly (GO:0046931)3.97167535
19DNA topological change (GO:0006265)3.95297876
20serine family amino acid biosynthetic process (GO:0009070)3.95169789
21pre-miRNA processing (GO:0031054)3.87395914
22DNA strand elongation involved in DNA replication (GO:0006271)3.83371657
23protein complex localization (GO:0031503)3.80271456
24DNA strand elongation (GO:0022616)3.75198894
25IMP metabolic process (GO:0046040)3.72747750
26cellular protein complex localization (GO:0034629)3.69595706
27one-carbon metabolic process (GO:0006730)3.67469886
28establishment of integrated proviral latency (GO:0075713)3.65920921
29folic acid-containing compound metabolic process (GO:0006760)3.65456526
30purine nucleobase biosynthetic process (GO:0009113)3.65044659
31regulation of centriole replication (GO:0046599)3.62374095
32regulation of spindle organization (GO:0090224)3.59752559
33DNA replication-dependent nucleosome assembly (GO:0006335)3.54678665
34DNA replication-dependent nucleosome organization (GO:0034723)3.54678665
35DNA geometric change (GO:0032392)3.46499149
36DNA duplex unwinding (GO:0032508)3.46406947
37chaperone-mediated protein complex assembly (GO:0051131)3.43482856
38regulation of mitotic spindle organization (GO:0060236)3.43388074
39regulation of RNA export from nucleus (GO:0046831)3.39912883
40serine family amino acid metabolic process (GO:0009069)3.39510004
41ribosome assembly (GO:0042255)3.38870485
42protein localization to chromosome, centromeric region (GO:0071459)3.37794133
43formation of translation preinitiation complex (GO:0001731)3.34065204
44nuclear envelope organization (GO:0006998)3.28436709
45protein export from nucleus (GO:0006611)3.27007931
46chromatin assembly (GO:0031497)3.25948822
47mitotic G1 DNA damage checkpoint (GO:0031571)3.23729553
48metaphase plate congression (GO:0051310)3.22045704
49telomere maintenance via semi-conservative replication (GO:0032201)3.21622270
50chromosome condensation (GO:0030261)3.20685626
51positive regulation of chromosome segregation (GO:0051984)3.20223586
52mitotic sister chromatid cohesion (GO:0007064)3.19164771
53regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.18665218
54proline biosynthetic process (GO:0006561)3.16858128
55regulation of translational elongation (GO:0006448)3.15047077
56DNA conformation change (GO:0071103)3.14495118
57regulation of posttranscriptional gene silencing (GO:0060147)3.13927503
58regulation of gene silencing by miRNA (GO:0060964)3.13927503
59regulation of gene silencing by RNA (GO:0060966)3.13927503
60sister chromatid segregation (GO:0000819)3.13805055
61amino acid activation (GO:0043038)3.10805353
62tRNA aminoacylation (GO:0043039)3.10805353
63NLS-bearing protein import into nucleus (GO:0006607)3.09894538
64histone H2A monoubiquitination (GO:0035518)3.08157088
65non-recombinational repair (GO:0000726)3.07052054
66double-strand break repair via nonhomologous end joining (GO:0006303)3.07052054
67pteridine-containing compound biosynthetic process (GO:0042559)2.97465621
68mitotic metaphase plate congression (GO:0007080)2.97443477
69serine family amino acid catabolic process (GO:0009071)2.97106756
70regulation of chromosome segregation (GO:0051983)2.96985002
71establishment of chromosome localization (GO:0051303)2.95139765
72negative regulation of histone methylation (GO:0031061)2.92897759
73DNA replication initiation (GO:0006270)2.92507197
74regulation of histone H3-K9 methylation (GO:0051570)2.92122050
75cysteine metabolic process (GO:0006534)2.89351281
76mitotic recombination (GO:0006312)2.87131566
77pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.86865358
78UMP metabolic process (GO:0046049)2.86865358
79pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.86865358
80UMP biosynthetic process (GO:0006222)2.86865358
81mitotic sister chromatid segregation (GO:0000070)2.86325253
82DNA packaging (GO:0006323)2.84464390
83regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.83515045
84mitotic chromosome condensation (GO:0007076)2.82980453
85telomere maintenance via recombination (GO:0000722)2.82482927
86nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.82110914
87ribosome biogenesis (GO:0042254)2.81997215
88maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.81980277
89histone-serine phosphorylation (GO:0035404)2.80272061
90DNA replication checkpoint (GO:0000076)2.79459530
91positive regulation of SMAD protein import into nucleus (GO:0060391)2.78959112
92nucleobase-containing small molecule interconversion (GO:0015949)2.78885189
93spliceosomal tri-snRNP complex assembly (GO:0000244)2.75944068
94mitotic G1/S transition checkpoint (GO:0044819)2.75870178
95regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.74792460
96regulation of nucleobase-containing compound transport (GO:0032239)2.74051500
97pteridine-containing compound metabolic process (GO:0042558)2.74026742
98peptidyl-lysine dimethylation (GO:0018027)2.72160902
99mRNA stabilization (GO:0048255)2.71885077
100RNA stabilization (GO:0043489)2.71885077
101paraxial mesoderm development (GO:0048339)2.71119331
102chromosome segregation (GO:0007059)2.70692917
103dosage compensation (GO:0007549)2.70672205
104regulation of sister chromatid cohesion (GO:0007063)2.69526684
105G1 DNA damage checkpoint (GO:0044783)2.69146676
106homocysteine metabolic process (GO:0050667)2.68932737
107DNA synthesis involved in DNA repair (GO:0000731)2.68484562
108L-alpha-amino acid transmembrane transport (GO:1902475)2.67728986
109tRNA aminoacylation for protein translation (GO:0006418)2.66469101
110negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.66150556
111peptidyl-arginine omega-N-methylation (GO:0035247)2.66046945
112negative regulation of chromosome segregation (GO:0051985)2.65973840
113negative regulation of mRNA metabolic process (GO:1903312)2.65923798
114regulation of centrosome duplication (GO:0010824)2.64932281
115glutamine metabolic process (GO:0006541)2.63870301
116positive regulation of cell cycle checkpoint (GO:1901978)2.63854084
1174-hydroxyproline metabolic process (GO:0019471)2.63832780
118mRNA transport (GO:0051028)2.63602052
119negative regulation of fatty acid biosynthetic process (GO:0045717)2.63375628
120COPII vesicle coating (GO:0048208)2.63090439
121dicarboxylic acid biosynthetic process (GO:0043650)2.62043483
122nucleosome disassembly (GO:0006337)2.60376958
123protein-DNA complex disassembly (GO:0032986)2.60376958
124spindle checkpoint (GO:0031577)2.59790398
125positive regulation of mitotic sister chromatid separation (GO:1901970)2.59666370
126positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.59666370
127positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.59666370
128mitotic cytokinesis (GO:0000281)2.59502576
129negative regulation of DNA repair (GO:0045738)2.59359197
130histone H2B ubiquitination (GO:0033523)2.59286690
131protein localization to chromosome (GO:0034502)2.59233736
132epithelial cell differentiation involved in prostate gland development (GO:0060742)2.58884182
133regulation of mitotic metaphase/anaphase transition (GO:0030071)2.58643796
134regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.58643796
135ATP-dependent chromatin remodeling (GO:0043044)2.58633608
136negative regulation of mRNA processing (GO:0050686)2.57918476
137positive regulation of nuclease activity (GO:0032075)2.57223931
138lysine metabolic process (GO:0006553)2.57117098
139lysine catabolic process (GO:0006554)2.57117098
140regulation of sister chromatid segregation (GO:0033045)2.56406312
141regulation of mitotic sister chromatid segregation (GO:0033047)2.56406312
142chromatin assembly or disassembly (GO:0006333)2.55401929
143activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.55285811
144Golgi transport vesicle coating (GO:0048200)2.55106434
145COPI coating of Golgi vesicle (GO:0048205)2.55106434
146monoubiquitinated protein deubiquitination (GO:0035520)2.54999419
147regulation of centrosome cycle (GO:0046605)2.54744334
148maternal placenta development (GO:0001893)2.53707960

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.00411898
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.38603421
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.60062935
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.54363567
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.15700736
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.03508933
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.79642621
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.72699006
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.72379552
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.58666687
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.44829679
12* AR_21909140_ChIP-Seq_LNCAP_Human2.43120654
13* MYC_22102868_ChIP-Seq_BL_Human2.39971011
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.38514458
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.30082912
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.22223834
17ESR1_15608294_ChIP-ChIP_MCF-7_Human1.96649973
18E2F1_21310950_ChIP-Seq_MCF-7_Human1.94681765
19* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94264574
20ZNF263_19887448_ChIP-Seq_K562_Human1.87403994
21MYC_18358816_ChIP-ChIP_MESCs_Mouse1.86774527
22PPARA_22158963_ChIP-Seq_LIVER_Mouse1.86443526
23POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.84916840
24STAT3_1855785_ChIP-Seq_MESCs_Mouse1.83420980
25* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77725168
26RXR_22158963_ChIP-Seq_LIVER_Mouse1.74385887
27SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.73424244
28CLOCK_20551151_ChIP-Seq_293T_Human1.69675442
29XRN2_22483619_ChIP-Seq_HELA_Human1.65550939
30* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58452978
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.57022602
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.56411130
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53347834
34SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.52371311
35WT1_19549856_ChIP-ChIP_CCG9911_Human1.50209212
36KLF4_18555785_ChIP-Seq_MESCs_Mouse1.47577886
37* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47128043
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.46895483
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43651171
40CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40414359
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.39842583
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39823316
43* KDM5A_27292631_Chip-Seq_BREAST_Human1.39469856
44TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37977955
45ELK1_19687146_ChIP-ChIP_HELA_Human1.34549508
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34408823
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33472769
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33354088
49* ETS1_20019798_ChIP-Seq_JURKAT_Human1.31865858
50* ATF3_27146783_Chip-Seq_COLON_Human1.29297064
51* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28055808
52TFEB_21752829_ChIP-Seq_HELA_Human1.27268255
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27115874
54LXR_22158963_ChIP-Seq_LIVER_Mouse1.24583548
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23711909
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21427347
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21038359
58SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20591303
59PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.19458787
60CHD1_26751641_Chip-Seq_LNCaP_Human1.17258697
61TCF3_18692474_ChIP-Seq_MEFs_Mouse1.17131744
62TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17085794
63KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16633909
64SOX17_20123909_ChIP-Seq_XEN_Mouse1.15034968
65GABP_19822575_ChIP-Seq_HepG2_Human1.14156216
66CIITA_25753668_ChIP-Seq_RAJI_Human1.13825690
67JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.13753116
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12540573
69ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11836327
70* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11067958
71DCP1A_22483619_ChIP-Seq_HELA_Human1.10232377
72HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10105187
73TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.07707313
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07089061
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06915228
76EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.06757988
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06636687
78NANOG_21062744_ChIP-ChIP_HESCs_Human1.06360538
79* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06349898
80TP63_17297297_ChIP-ChIP_HaCaT_Human1.06158240
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06105209
82TCF7_22412390_ChIP-Seq_EML_Mouse1.05344226
83NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.04918132
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04135657
85GATA1_22025678_ChIP-Seq_K562_Human1.03909964
86* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03657445
87KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03602814
88TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03538838
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03412034
90YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03234890
91VDR_21846776_ChIP-Seq_THP-1_Human1.02895199
92HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02146416
93SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01692232
94EST1_17652178_ChIP-ChIP_JURKAT_Human1.01030395
95VDR_23849224_ChIP-Seq_CD4+_Human1.00953047
96TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00948838
97TTF2_22483619_ChIP-Seq_HELA_Human1.00462106
98NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00328129
99FOXP3_21729870_ChIP-Seq_TREG_Human1.00155015
100* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00051653
101KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99271255
102KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99271255
103KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99271255
104P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97215014
105HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96877098
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96510447
107WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96325873
108CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96189435
109NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95828145
110HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95604733
111SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95168693
112PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95081885
113SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93868774
114ELK3_25401928_ChIP-Seq_HUVEC_Human0.92758695
115NCOR1_26117541_ChIP-Seq_K562_Human0.92723557
116* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92134492
117NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.91781753
118PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91695072
119RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91038638
120TCF3_18692474_ChIP-Seq_MESCs_Mouse0.90459463
121* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.89848539
122DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88689546
123PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88434950
124SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.86408519
125SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.86408519
126KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86260913
127CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.84027560
128PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83845402
129GATA4_21415370_ChIP-Seq_HL-1_Mouse0.81742108

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.22906210
2MP0010352_gastrointestinal_tract_polyps3.36614794
3MP0003111_abnormal_nucleus_morphology3.02017286
4MP0002139_abnormal_hepatobiliary_system2.93250513
5MP0003693_abnormal_embryo_hatching2.82490598
6MP0004957_abnormal_blastocyst_morpholog2.73741091
7MP0010094_abnormal_chromosome_stability2.61707492
8MP0010307_abnormal_tumor_latency2.55004722
9MP0010234_abnormal_vibrissa_follicle2.49978371
10MP0003806_abnormal_nucleotide_metabolis2.43917818
11MP0005360_urolithiasis2.34929676
12MP0005076_abnormal_cell_differentiation2.33492041
13MP0003941_abnormal_skin_development2.24505913
14MP0003077_abnormal_cell_cycle2.22909137
15MP0001730_embryonic_growth_arrest2.21405019
16MP0008057_abnormal_DNA_replication2.14312228
17MP0005085_abnormal_gallbladder_physiolo2.13163118
18MP0003123_paternal_imprinting2.12348858
19MP0005365_abnormal_bile_salt2.08773904
20MP0002009_preneoplasia2.07540812
21MP0008438_abnormal_cutaneous_collagen1.86831774
22MP0004197_abnormal_fetal_growth/weight/1.86758782
23MP0000350_abnormal_cell_proliferation1.85135502
24MP0004272_abnormal_basement_membrane1.82738768
25MP0009840_abnormal_foam_cell1.80262641
26MP0003566_abnormal_cell_adhesion1.78835913
27MP0005380_embryogenesis_phenotype1.71283872
28MP0001672_abnormal_embryogenesis/_devel1.71283872
29MP0009053_abnormal_anal_canal1.67852592
30MP0002086_abnormal_extraembryonic_tissu1.65450189
31MP0002084_abnormal_developmental_patter1.65041323
32MP0003252_abnormal_bile_duct1.61409860
33MP0002088_abnormal_embryonic_growth/wei1.61312390
34MP0003984_embryonic_growth_retardation1.61255796
35MP0002396_abnormal_hematopoietic_system1.59248686
36MP0001697_abnormal_embryo_size1.55868469
37MP0000537_abnormal_urethra_morphology1.55381739
38MP0002877_abnormal_melanocyte_morpholog1.51569130
39MP0002080_prenatal_lethality1.50715179
40MP0009697_abnormal_copulation1.49227861
41MP0005083_abnormal_biliary_tract1.49185701
42MP0009672_abnormal_birth_weight1.43516538
43MP0002085_abnormal_embryonic_tissue1.39796652
44MP0008007_abnormal_cellular_replicative1.38742001
45MP0005023_abnormal_wound_healing1.37644602
46MP0004808_abnormal_hematopoietic_stem1.33507002
47MP0002796_impaired_skin_barrier1.31890883
48MP0003300_gastrointestinal_ulcer1.31701911
49MP0004185_abnormal_adipocyte_glucose1.28936840
50MP0003283_abnormal_digestive_organ1.28824776
51MP0005501_abnormal_skin_physiology1.27766985
52MP0006054_spinal_hemorrhage1.23552889
53MP0010329_abnormal_lipoprotein_level1.22567023
54MP0000579_abnormal_nail_morphology1.22429564
55MP0001915_intracranial_hemorrhage1.19731045
56MP0003890_abnormal_embryonic-extraembry1.19570472
57MP0001661_extended_life_span1.14403024
58MP0003567_abnormal_fetal_cardiomyocyte1.14228451
59MP0009703_decreased_birth_body1.13590193
60MP0000733_abnormal_muscle_development1.13115498
61MP0000609_abnormal_liver_physiology1.11348838
62MP0008932_abnormal_embryonic_tissue1.09089378
63MP0003385_abnormal_body_wall1.07738045
64MP0000598_abnormal_liver_morphology1.06880661
65MP0000428_abnormal_craniofacial_morphol1.06478122
66MP0001849_ear_inflammation1.05745150
67MP0010030_abnormal_orbit_morphology1.05668038
68MP0004233_abnormal_muscle_weight1.05168483
69MP0008058_abnormal_DNA_repair1.03611492
70MP0010678_abnormal_skin_adnexa1.03249581
71MP0005275_abnormal_skin_tensile1.02634356
72MP0003119_abnormal_digestive_system1.02321631
73MP0001666_abnormal_nutrient_absorption1.02049802
74MP0001293_anophthalmia1.01228789
75MP0002092_abnormal_eye_morphology1.01082304
76MP0005623_abnormal_meninges_morphology1.01075531
77MP0000762_abnormal_tongue_morphology1.00564313
78MP0004264_abnormal_extraembryonic_tissu1.00480819
79MP0000627_abnormal_mammary_gland0.99446328
80MP0005220_abnormal_exocrine_pancreas0.95662213
81MP0003942_abnormal_urinary_system0.95051082
82MP0002111_abnormal_tail_morphology0.94508103
83MP0000432_abnormal_head_morphology0.93726451
84MP0003868_abnormal_feces_composition0.93056453
85MP0000569_abnormal_digit_pigmentation0.91994850
86MP0005257_abnormal_intraocular_pressure0.90122528
87MP0000490_abnormal_crypts_of0.89200612
88MP0001299_abnormal_eye_distance/0.89057180
89MP0004782_abnormal_surfactant_physiolog0.88927611
90MP0002697_abnormal_eye_size0.88855257
91MP0003935_abnormal_craniofacial_develop0.88465335
92MP0009278_abnormal_bone_marrow0.88048440
93MP0005666_abnormal_adipose_tissue0.86805110
94MP0005503_abnormal_tendon_morphology0.85902547
95MP0003315_abnormal_perineum_morphology0.85624820
96MP0002019_abnormal_tumor_incidence0.85487368
97MP0005451_abnormal_body_composition0.85281660
98MP0001286_abnormal_eye_development0.84903717
99MP0003786_premature_aging0.83393334
100MP0003115_abnormal_respiratory_system0.83017160
101MP0000313_abnormal_cell_death0.81964727
102MP0003718_maternal_effect0.81767689
103MP0008770_decreased_survivor_rate0.81237257
104MP0001243_abnormal_dermal_layer0.81205558
105MP0000358_abnormal_cell_content/0.80931721
106MP0005621_abnormal_cell_physiology0.80270400
107MP0001881_abnormal_mammary_gland0.79956638
108MP0000371_diluted_coat_color0.79575278
109MP0003453_abnormal_keratinocyte_physiol0.79515840
110MP0005409_darkened_coat_color0.79360473
111MP0008875_abnormal_xenobiotic_pharmacok0.79032532
112MP0002098_abnormal_vibrissa_morphology0.79030202
113MP0001216_abnormal_epidermal_layer0.78243458
114MP0009384_cardiac_valve_regurgitation0.76740918
115MP0000467_abnormal_esophagus_morphology0.76464992
116MP0005319_abnormal_enzyme/_coenzyme0.74770040
117MP0001545_abnormal_hematopoietic_system0.74508698
118MP0005397_hematopoietic_system_phenotyp0.74508698
119MP0005384_cellular_phenotype0.73955330
120MP0003221_abnormal_cardiomyocyte_apopto0.73737267
121MP0003091_abnormal_cell_migration0.73171813
122MP0003755_abnormal_palate_morphology0.72817960
123MP0002269_muscular_atrophy0.72445499
124MP0008961_abnormal_basal_metabolism0.72388604
125MP0005332_abnormal_amino_acid0.72165671
126MP0002896_abnormal_bone_mineralization0.71885115
127MP0003656_abnormal_erythrocyte_physiolo0.71266145
128MP0005187_abnormal_penis_morphology0.70516527
129MP0004858_abnormal_nervous_system0.69591899
130MP0001346_abnormal_lacrimal_gland0.69502476
131MP0000534_abnormal_ureter_morphology0.68408580
132MP0003937_abnormal_limbs/digits/tail_de0.67509600
133MP0003172_abnormal_lysosome_physiology0.66162089
134MP0000377_abnormal_hair_follicle0.65957738
135MP0002925_abnormal_cardiovascular_devel0.64619677
136MP0002060_abnormal_skin_morphology0.64331916

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)3.79795239
2Chromsome breakage (HP:0040012)3.79441064
3Protrusio acetabuli (HP:0003179)3.43821997
4Ependymoma (HP:0002888)3.42415899
5Spastic diplegia (HP:0001264)3.25226733
6Asymmetry of the thorax (HP:0001555)3.12046054
7Abnormality of monocarboxylic acid metabolism (HP:0010996)2.92239450
8Deep venous thrombosis (HP:0002625)2.87029742
9Abnormality of the astrocytes (HP:0100707)2.83962953
10Astrocytoma (HP:0009592)2.83962953
11Ankle contracture (HP:0006466)2.82678959
12Termporal pattern (HP:0011008)2.80230858
13Insidious onset (HP:0003587)2.80230858
14Premature rupture of membranes (HP:0001788)2.80177160
15Ankyloglossia (HP:0010296)2.74147817
16Insomnia (HP:0100785)2.68531397
17Intrahepatic cholestasis (HP:0001406)2.57768943
18Deep philtrum (HP:0002002)2.57175213
19Hyperglycinemia (HP:0002154)2.53943543
20Cerebral aneurysm (HP:0004944)2.52792790
21Selective tooth agenesis (HP:0001592)2.51775011
22Nephroblastoma (Wilms tumor) (HP:0002667)2.50293951
23Genu recurvatum (HP:0002816)2.44526543
24Abnormality of the lower motor neuron (HP:0002366)2.40825550
25Hypobetalipoproteinemia (HP:0003563)2.40613276
26Embryonal renal neoplasm (HP:0011794)2.36757882
27Shallow orbits (HP:0000586)2.33348795
28Hand muscle atrophy (HP:0009130)2.28518311
29Pseudobulbar signs (HP:0002200)2.28507176
30Abnormality of the Achilles tendon (HP:0005109)2.27639388
31Sparse lateral eyebrow (HP:0005338)2.27176273
32Microglossia (HP:0000171)2.27098338
33Subacute progressive viral hepatitis (HP:0006572)2.25019414
34Abnormality of oral frenula (HP:0000190)2.24572664
35Xanthomatosis (HP:0000991)2.24091229
36Syringomyelia (HP:0003396)2.23328921
37Spinal cord lesions (HP:0100561)2.23328921
38Abnormality of sulfur amino acid metabolism (HP:0004339)2.21811667
39Overlapping toe (HP:0001845)2.20643006
40Bowel diverticulosis (HP:0005222)2.20216174
41Glioma (HP:0009733)2.19854684
42Ulnar bowing (HP:0003031)2.18494930
43Deviation of the thumb (HP:0009603)2.18271930
44Abnormality of pyrimidine metabolism (HP:0004353)2.18007701
45Rhabdomyosarcoma (HP:0002859)2.16009910
46Overriding aorta (HP:0002623)2.15352364
47Achilles tendon contracture (HP:0001771)2.14489021
48Mitral valve prolapse (HP:0001634)2.14017328
49Biliary tract neoplasm (HP:0100574)2.14006975
50Upper limb amyotrophy (HP:0009129)2.13822653
51Distal upper limb amyotrophy (HP:0007149)2.13822653
52Enlarged penis (HP:0000040)2.11815983
53Proximal placement of thumb (HP:0009623)2.09888067
54Resting tremor (HP:0002322)2.08476914
55Abnormality of glycine metabolism (HP:0010895)2.07103764
56Abnormality of serine family amino acid metabolism (HP:0010894)2.07103764
57Colon cancer (HP:0003003)2.05662313
58Cervical subluxation (HP:0003308)2.05113412
59Hyperacusis (HP:0010780)2.04721225
60Back pain (HP:0003418)2.03874269
61Renal duplication (HP:0000075)2.00995601
62Elfin facies (HP:0004428)2.00054891
63Pelvic girdle muscle weakness (HP:0003749)1.99654488
64Heterotopia (HP:0002282)1.98023196
65Dysmetric saccades (HP:0000641)1.97481544
66Increased nuchal translucency (HP:0010880)1.97444990
67Upper limb muscle weakness (HP:0003484)1.96385056
68Dilatation of the ascending aorta (HP:0005111)1.94413675
69Relative macrocephaly (HP:0004482)1.93967238
70Increased density of long bones (HP:0006392)1.93495836
71Abnormal cartilage morphology (HP:0002763)1.93469756
72Hypolipoproteinemia (HP:0010981)1.92575952
73Breech presentation (HP:0001623)1.92156090
74Cortical dysplasia (HP:0002539)1.90638781
75Fibroma (HP:0010614)1.89724115
76Angiofibromas (HP:0010615)1.88563695
77Adenoma sebaceum (HP:0009720)1.88563695
78Abnormality of the calcaneus (HP:0008364)1.88438738
79Missing ribs (HP:0000921)1.88373953
80Cafe-au-lait spot (HP:0000957)1.87817263
81Fibrous tissue neoplasm (HP:0012316)1.87723141
82Medulloblastoma (HP:0002885)1.87722556
83Abnormality of chromosome stability (HP:0003220)1.87281611
84Metaphyseal cupping (HP:0003021)1.86756634
85Macroorchidism (HP:0000053)1.86725428
86Malignant gastrointestinal tract tumors (HP:0006749)1.86407829
87Gastrointestinal carcinoma (HP:0002672)1.86407829
88Renovascular hypertension (HP:0100817)1.86189371
89High pitched voice (HP:0001620)1.86181786
90High anterior hairline (HP:0009890)1.85831932
91Hyperglycinuria (HP:0003108)1.85723167
92Abnormality of the labia minora (HP:0012880)1.85657687
93Unilateral renal agenesis (HP:0000122)1.85493037
94Leiomyosarcoma (HP:0100243)1.84762093
95Uterine leiomyosarcoma (HP:0002891)1.84762093
96Hepatocellular carcinoma (HP:0001402)1.83307400
97Abnormality of the umbilical cord (HP:0010881)1.82947989
98Birth length less than 3rd percentile (HP:0003561)1.82222957
99Neoplasm of striated muscle (HP:0009728)1.82137252
100Orthostatic hypotension (HP:0001278)1.82056401
101Global brain atrophy (HP:0002283)1.80492753
102Prominent nose (HP:0000448)1.80131308
103Abnormality of the preputium (HP:0100587)1.79986019
104Multiple enchondromatosis (HP:0005701)1.79592694
105Cutaneous melanoma (HP:0012056)1.77423656
106Osteolytic defects of the phalanges of the hand (HP:0009771)1.77206803
107Osteolytic defects of the hand bones (HP:0009699)1.77206803
108Acute myeloid leukemia (HP:0004808)1.77038312
109Flat cornea (HP:0007720)1.76319427
110Peritonitis (HP:0002586)1.76005237
111Hammertoe (HP:0001765)1.75766342
112Short 4th metacarpal (HP:0010044)1.75746003
113Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.75746003
114Advanced eruption of teeth (HP:0006288)1.75222957
115Radial bowing (HP:0002986)1.74781311
116Impulsivity (HP:0100710)1.74758620
117Degeneration of anterior horn cells (HP:0002398)1.74724044
118Abnormality of the anterior horn cell (HP:0006802)1.74724044
119Basal cell carcinoma (HP:0002671)1.73114636
120Patellar dislocation (HP:0002999)1.72364748
121Reticulocytosis (HP:0001923)1.72305507
122Hypoalphalipoproteinemia (HP:0003233)1.72043650
123Abnormality of the common coagulation pathway (HP:0010990)1.71857224
124Hallux valgus (HP:0001822)1.71748262
125Abnormality of the carotid arteries (HP:0005344)1.71520900
126Septate vagina (HP:0001153)1.71478580
127Myelodysplasia (HP:0002863)1.71149607
128Progressive muscle weakness (HP:0003323)1.71136543
129Disproportionate tall stature (HP:0001519)1.70806168
130Wormian bones (HP:0002645)1.69538719
131Pterygium (HP:0001059)1.68371517
132Progressive external ophthalmoplegia (HP:0000590)1.67914943
133Vertebral compression fractures (HP:0002953)1.67723877
134Turricephaly (HP:0000262)1.67048113
135Abnormality of the intrinsic pathway (HP:0010989)1.66354159
136Hypopigmentation of the fundus (HP:0007894)1.66222864
137Abnormality of the peritoneum (HP:0002585)1.66191454
138Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.65762325
139Biconcave vertebral bodies (HP:0004586)1.65104151
140Vertebral arch anomaly (HP:0008438)1.65034188
141Deviation of the hallux (HP:0010051)1.63496909
142Arterial tortuosity (HP:0005116)1.63298193
143Facial hemangioma (HP:0000329)1.62856165
144Papillary thyroid carcinoma (HP:0002895)1.61577155
145Myocardial infarction (HP:0001658)1.61562343
146Bladder diverticulum (HP:0000015)1.61401518
147Embryonal neoplasm (HP:0002898)1.60952839
148Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.60949598
149Neoplasm of the oral cavity (HP:0100649)1.60882907
150Aneurysm (HP:0002617)1.60205234
151Lymphangioma (HP:0100764)1.60095928
152Increased mean platelet volume (HP:0011877)1.59915360
153Abnormality of glycolysis (HP:0004366)1.59820138
154Upper motor neuron abnormality (HP:0002127)1.59549640
155Arnold-Chiari malformation (HP:0002308)1.59522507
156Vertebral clefting (HP:0008428)1.59147072
157Abnormality of chromosome segregation (HP:0002916)1.58579558
158Cubitus valgus (HP:0002967)1.58332471
159Meckel diverticulum (HP:0002245)1.58261261
160Transitional cell carcinoma of the bladder (HP:0006740)1.57838802
161Natal tooth (HP:0000695)1.57590510
162Atrophic scars (HP:0001075)1.57169016
163Trismus (HP:0000211)1.56676022
164Abnormality of nail color (HP:0100643)1.56579928
165Long palpebral fissure (HP:0000637)1.56032888
166Vascular tortuosity (HP:0004948)1.53733238
167Sandal gap (HP:0001852)1.53162858
168Curly hair (HP:0002212)1.52835576
169Duodenal stenosis (HP:0100867)1.52663286
170Small intestinal stenosis (HP:0012848)1.52663286
171Choanal atresia (HP:0000453)1.52509882
172Short middle phalanx of the 5th finger (HP:0004220)1.52299557

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN24.09550466
2EEF2K3.61315777
3TRIB33.57365110
4WEE12.76531794
5CDK122.73434470
6CDC72.72023167
7NEK12.47122674
8SCYL22.43188976
9NEK22.40239967
10SMG12.38911330
11PBK2.17769078
12LATS12.05122639
13FLT31.96397312
14EPHA21.91541822
15MAP3K101.90563725
16ALK1.85748539
17TTK1.84969779
18PDGFRA1.73133286
19TSSK61.72236030
20TAF11.61657814
21BUB11.57790421
22PASK1.57479335
23RPS6KB21.55826569
24MAP3K81.50804749
25CDK61.50354678
26PTK61.46716951
27STK31.42766436
28MST1R1.40023680
29CDK41.39248327
30TTN1.35954320
31MTOR1.35741456
32STK101.33013521
33EIF2AK11.32941956
34RIPK11.28304163
35PAK41.27444323
36BRSK21.27351789
37LATS21.26516235
38SIK11.21505511
39IRAK31.20442047
40DDR21.20319436
41ERN11.19452115
42PAK21.16967717
43NTRK11.12778644
44LRRK21.11692361
45PLK41.09925740
46PLK11.09668287
47RPS6KA41.09457058
48MAP2K31.01654618
49CHEK11.01526124
50ATR1.01163140
51PLK31.00002377
52AURKB0.96460558
53CLK10.93413750
54BMX0.90935004
55PDK40.89223150
56PDK30.89223150
57MKNK20.88074710
58CDK70.88063731
59BRD40.86827903
60FGFR10.86205688
61BCKDK0.83372391
62TGFBR10.82942405
63PNCK0.80878861
64SRPK10.79474521
65CDK80.78929760
66CDK20.78860379
67EIF2AK20.75998446
68CAMK1D0.74829755
69BRAF0.74005217
70CHEK20.73488493
71DYRK30.73289649
72FGFR40.70700628
73MKNK10.70035766
74EIF2AK30.68630432
75MAP3K90.68382102
76MAP3K30.67509793
77PIM10.66591998
78ATM0.65900775
79PRPF4B0.65107997
80PDGFRB0.64553440
81MET0.63671879
82TAOK20.62910228
83CSNK1E0.60720121
84BRSK10.60174928
85AKT20.59325077
86STK38L0.58326858
87PTK20.56813503
88ERBB30.56114665
89RET0.55844309
90ICK0.55665117
91VRK20.54737546
92TAOK10.54596681
93NEK60.54228167
94PRKD30.52911071
95AURKA0.52821903
96MAP3K50.52293822
97RAF10.51199715
98MELK0.48844885
99CSNK1D0.48751983
100CDK10.48145346
101NME20.46973085
102CAMKK10.46636244
103MAP3K110.46410347
104CDK180.46135053
105CDK150.43674966
106AKT30.43402534
107RPS6KB10.42943489
108YES10.42921692
109PRKDC0.42794246
110BCR0.42398279
111ACVR1B0.42193134
112NEK90.41481094
113STK40.41072372
114CDK11A0.41006003
115ILK0.40922476
116CSNK2A20.40754575
117KSR20.40301102
118FGFR30.39944882
119ERBB40.38541456
120CDK90.38107382
121TYRO30.37655219
122GRK60.35665123
123CDK140.35585375
124MAPK140.33834548
125STK240.33043702
126MAPKAPK30.32296066
127EGFR0.32276994
128CAMK1G0.32243898
129KSR10.31643837
130FRK0.31278927

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006703.84675422
2Nitrogen metabolism_Homo sapiens_hsa009103.59596136
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.89167989
4Selenocompound metabolism_Homo sapiens_hsa004502.55088812
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.49472664
6* RNA transport_Homo sapiens_hsa030132.34623569
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.31322471
8DNA replication_Homo sapiens_hsa030302.16763081
9Biosynthesis of amino acids_Homo sapiens_hsa012302.08955801
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.08327810
11Arginine biosynthesis_Homo sapiens_hsa002202.05981619
12Cyanoamino acid metabolism_Homo sapiens_hsa004602.02281854
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.90372123
14Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.85586989
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.78424075
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.77334304
17Vitamin B6 metabolism_Homo sapiens_hsa007501.75789318
18Cell cycle_Homo sapiens_hsa041101.67216174
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.66917620
20Mismatch repair_Homo sapiens_hsa034301.63619415
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.58435139
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.44386678
23Spliceosome_Homo sapiens_hsa030401.40003316
24Carbon metabolism_Homo sapiens_hsa012001.35897736
25Lysine degradation_Homo sapiens_hsa003101.27987769
26Fanconi anemia pathway_Homo sapiens_hsa034601.26129772
27Pancreatic cancer_Homo sapiens_hsa052121.23651486
28mTOR signaling pathway_Homo sapiens_hsa041501.22799978
29mRNA surveillance pathway_Homo sapiens_hsa030151.21963015
30Central carbon metabolism in cancer_Homo sapiens_hsa052301.16368504
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.15522471
32p53 signaling pathway_Homo sapiens_hsa041151.14828376
33Systemic lupus erythematosus_Homo sapiens_hsa053221.11573430
34Pentose phosphate pathway_Homo sapiens_hsa000301.06561820
35Viral carcinogenesis_Homo sapiens_hsa052031.04176084
36Nucleotide excision repair_Homo sapiens_hsa034201.02635574
37Base excision repair_Homo sapiens_hsa034101.01433747
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00767022
39Fatty acid degradation_Homo sapiens_hsa000710.98937847
40Renal cell carcinoma_Homo sapiens_hsa052110.98773467
41Basal transcription factors_Homo sapiens_hsa030220.97333452
42MicroRNAs in cancer_Homo sapiens_hsa052060.95976950
43Chronic myeloid leukemia_Homo sapiens_hsa052200.95443738
44Tryptophan metabolism_Homo sapiens_hsa003800.93460466
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92781844
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92388661
47Small cell lung cancer_Homo sapiens_hsa052220.90930128
48N-Glycan biosynthesis_Homo sapiens_hsa005100.89614013
49Complement and coagulation cascades_Homo sapiens_hsa046100.89474092
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86489127
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85338775
52Bladder cancer_Homo sapiens_hsa052190.84160766
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82431995
54Sulfur relay system_Homo sapiens_hsa041220.81756846
55Melanoma_Homo sapiens_hsa052180.80482902
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78721961
57ErbB signaling pathway_Homo sapiens_hsa040120.78651377
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78238250
59Thyroid cancer_Homo sapiens_hsa052160.74693555
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74453036
61Fat digestion and absorption_Homo sapiens_hsa049750.73615245
62Oocyte meiosis_Homo sapiens_hsa041140.70626255
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69880879
64ECM-receptor interaction_Homo sapiens_hsa045120.69397437
65Proteoglycans in cancer_Homo sapiens_hsa052050.69261284
66Bile secretion_Homo sapiens_hsa049760.68799729
67Folate biosynthesis_Homo sapiens_hsa007900.67297320
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64035669
69PPAR signaling pathway_Homo sapiens_hsa033200.63065529
70Fatty acid metabolism_Homo sapiens_hsa012120.62337838
71Non-small cell lung cancer_Homo sapiens_hsa052230.61534593
72Steroid biosynthesis_Homo sapiens_hsa001000.61214086
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60906497
74Wnt signaling pathway_Homo sapiens_hsa043100.59901757
75Hippo signaling pathway_Homo sapiens_hsa043900.59804415
76HTLV-I infection_Homo sapiens_hsa051660.59336092
77AMPK signaling pathway_Homo sapiens_hsa041520.58531334
78Pyrimidine metabolism_Homo sapiens_hsa002400.58040868
79Caffeine metabolism_Homo sapiens_hsa002320.57560491
80Insulin resistance_Homo sapiens_hsa049310.56789895
81Pyruvate metabolism_Homo sapiens_hsa006200.54639899
82Pathways in cancer_Homo sapiens_hsa052000.54499361
83Tight junction_Homo sapiens_hsa045300.54258258
84Fatty acid biosynthesis_Homo sapiens_hsa000610.54021820
85Inositol phosphate metabolism_Homo sapiens_hsa005620.53224857
86Glucagon signaling pathway_Homo sapiens_hsa049220.52962270
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52704558
88Butanoate metabolism_Homo sapiens_hsa006500.52152880
89Prion diseases_Homo sapiens_hsa050200.51828443
90Starch and sucrose metabolism_Homo sapiens_hsa005000.51611144
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51549870
92Antigen processing and presentation_Homo sapiens_hsa046120.50082894
93Propanoate metabolism_Homo sapiens_hsa006400.49210425
94Hepatitis B_Homo sapiens_hsa051610.49147989
95Homologous recombination_Homo sapiens_hsa034400.48027019
96RNA degradation_Homo sapiens_hsa030180.47881170
97Adherens junction_Homo sapiens_hsa045200.47580330
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47516721
99beta-Alanine metabolism_Homo sapiens_hsa004100.47440928
100Proteasome_Homo sapiens_hsa030500.47278684
101Arginine and proline metabolism_Homo sapiens_hsa003300.47142885
102VEGF signaling pathway_Homo sapiens_hsa043700.46410076
103Estrogen signaling pathway_Homo sapiens_hsa049150.46054831
104Insulin signaling pathway_Homo sapiens_hsa049100.45915103
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.44528114
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44438797
107Choline metabolism in cancer_Homo sapiens_hsa052310.44252727
108Endometrial cancer_Homo sapiens_hsa052130.43795786
109Shigellosis_Homo sapiens_hsa051310.43705144
110Glioma_Homo sapiens_hsa052140.43330031
111RNA polymerase_Homo sapiens_hsa030200.43296251
112Focal adhesion_Homo sapiens_hsa045100.43041539
113Prostate cancer_Homo sapiens_hsa052150.42076958
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41854852
115HIF-1 signaling pathway_Homo sapiens_hsa040660.41743986
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41693872
117Prolactin signaling pathway_Homo sapiens_hsa049170.41566602
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41506057
119Fructose and mannose metabolism_Homo sapiens_hsa000510.41443527
120Non-homologous end-joining_Homo sapiens_hsa034500.40873162
121Epstein-Barr virus infection_Homo sapiens_hsa051690.40688912
122Purine metabolism_Homo sapiens_hsa002300.39892958
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39842813
124Alcoholism_Homo sapiens_hsa050340.38897491
125Galactose metabolism_Homo sapiens_hsa000520.38636557
126Colorectal cancer_Homo sapiens_hsa052100.36397803
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35962859
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.35489391
129Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34502045
130Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34458512
131TGF-beta signaling pathway_Homo sapiens_hsa043500.34453348
132Basal cell carcinoma_Homo sapiens_hsa052170.33961136
133Acute myeloid leukemia_Homo sapiens_hsa052210.32585584
134Phenylalanine metabolism_Homo sapiens_hsa003600.32222013

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