XRCC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.04208853
2DNA unwinding involved in DNA replication (GO:0006268)4.95767704
3viral life cycle (GO:0019058)4.87617003
4cellular protein complex disassembly (GO:0043624)4.84151885
5DNA strand elongation (GO:0022616)4.79381444
6establishment of protein localization to endoplasmic reticulum (GO:0072599)4.67773372
7telomere maintenance via semi-conservative replication (GO:0032201)4.65500543
8protein localization to kinetochore (GO:0034501)4.61774665
9DNA replication initiation (GO:0006270)4.59162421
10protein complex disassembly (GO:0043241)4.56880986
11protein localization to endoplasmic reticulum (GO:0070972)4.53190843
12formation of translation preinitiation complex (GO:0001731)4.36318738
13macromolecular complex disassembly (GO:0032984)4.27257024
14DNA replication checkpoint (GO:0000076)4.16469526
15nucleobase biosynthetic process (GO:0046112)4.14388482
16DNA replication-dependent nucleosome organization (GO:0034723)4.12118540
17DNA replication-dependent nucleosome assembly (GO:0006335)4.12118540
18protein localization to chromosome, centromeric region (GO:0071459)4.09621604
19telomere maintenance via recombination (GO:0000722)4.08764572
20deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.97935840
21mitotic recombination (GO:0006312)3.94327812
22mitotic metaphase plate congression (GO:0007080)3.84726509
23mitotic nuclear envelope disassembly (GO:0007077)3.82906429
24peptidyl-arginine omega-N-methylation (GO:0035247)3.81842917
25mitotic sister chromatid segregation (GO:0000070)3.81361169
26purine nucleobase biosynthetic process (GO:0009113)3.80427594
27somatic diversification of immune receptors via somatic mutation (GO:0002566)3.78307004
28somatic hypermutation of immunoglobulin genes (GO:0016446)3.78307004
29DNA deamination (GO:0045006)3.76794706
30maturation of SSU-rRNA (GO:0030490)3.74596008
31telomere maintenance via telomere lengthening (GO:0010833)3.71190678
32nucleotide-excision repair, DNA gap filling (GO:0006297)3.63001500
33ribosomal small subunit assembly (GO:0000028)3.62254130
34nuclear-transcribed mRNA catabolic process (GO:0000956)3.60981415
35viral transcription (GO:0019083)3.60292888
36pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.59894925
37folic acid-containing compound biosynthetic process (GO:0009396)3.59273457
38regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.55915279
39nuclear envelope disassembly (GO:0051081)3.51269476
40membrane disassembly (GO:0030397)3.51269476
41sister chromatid segregation (GO:0000819)3.51005022
42translational termination (GO:0006415)3.50807229
43regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.47803037
44peptidyl-arginine N-methylation (GO:0035246)3.46542770
45peptidyl-arginine methylation (GO:0018216)3.46542770
46mRNA catabolic process (GO:0006402)3.46242376
47negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.45215068
48mitotic chromosome condensation (GO:0007076)3.44681196
49histone arginine methylation (GO:0034969)3.43651707
50metaphase plate congression (GO:0051310)3.41855613
51IMP biosynthetic process (GO:0006188)3.41546747
52protein targeting to membrane (GO:0006612)3.41196092
53pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.39617623
54UTP biosynthetic process (GO:0006228)3.39357928
55translational elongation (GO:0006414)3.36421232
56nuclear pore organization (GO:0006999)3.36241760
57chromatin remodeling at centromere (GO:0031055)3.36168846
58pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.35877622
59DNA duplex unwinding (GO:0032508)3.35825510
60DNA geometric change (GO:0032392)3.35254031
61CENP-A containing nucleosome assembly (GO:0034080)3.34936574
62translational initiation (GO:0006413)3.33189623
63DNA replication-independent nucleosome assembly (GO:0006336)3.29337607
64DNA replication-independent nucleosome organization (GO:0034724)3.29337607
65regulation of spindle organization (GO:0090224)3.27464878
66kinetochore organization (GO:0051383)3.27458306
67spliceosomal snRNP assembly (GO:0000387)3.26886036
68ribosomal large subunit biogenesis (GO:0042273)3.25957404
69energy coupled proton transport, down electrochemical gradient (GO:0015985)3.20711568
70ATP synthesis coupled proton transport (GO:0015986)3.20711568
71ribosome biogenesis (GO:0042254)3.20334354
72attachment of spindle microtubules to kinetochore (GO:0008608)3.18636989
73nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.18431945
74RNA catabolic process (GO:0006401)3.17932134
75microtubule depolymerization (GO:0007019)3.16997770
76nucleosome disassembly (GO:0006337)3.16906154
77protein-DNA complex disassembly (GO:0032986)3.16906154
78negative regulation of RNA splicing (GO:0033119)3.16016951
79GTP biosynthetic process (GO:0006183)3.14585973
80pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.14277957
81protein localization to chromosome (GO:0034502)3.13798731
82negative regulation of chromosome segregation (GO:0051985)3.13223885
83ribonucleoprotein complex biogenesis (GO:0022613)3.12923472
84regulation of chromosome segregation (GO:0051983)3.11710823
85ribosome assembly (GO:0042255)3.09900564
86regulation of nuclear cell cycle DNA replication (GO:0033262)3.07780597
87positive regulation of chromosome segregation (GO:0051984)3.06199730
88ribosomal small subunit biogenesis (GO:0042274)3.06004723
89negative regulation of mitotic sister chromatid separation (GO:2000816)3.05767188
90negative regulation of mitotic sister chromatid segregation (GO:0033048)3.05767188
91negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.05767188
92negative regulation of sister chromatid segregation (GO:0033046)3.05767188
93mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.05357555
94translation (GO:0006412)3.05287801
95guanosine-containing compound biosynthetic process (GO:1901070)3.03760368
96base-excision repair, AP site formation (GO:0006285)3.03474764
97regulation of mitochondrial translation (GO:0070129)3.03297569
98mRNA splicing, via spliceosome (GO:0000398)3.02647200
99RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.02647200
100spliceosomal complex assembly (GO:0000245)3.02172923
101translesion synthesis (GO:0019985)3.01948637
102histone H2A acetylation (GO:0043968)3.01568307
103DNA topological change (GO:0006265)3.01547909
104pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.01000775
105establishment of chromosome localization (GO:0051303)3.00836799
106kinetochore assembly (GO:0051382)3.00819480
107RNA splicing, via transesterification reactions (GO:0000375)3.00690727
108DNA conformation change (GO:0071103)2.99389134
109mitotic spindle assembly checkpoint (GO:0007094)2.99348883
110spindle assembly checkpoint (GO:0071173)2.99096826
111pyrimidine nucleotide catabolic process (GO:0006244)2.98424083
112nuclear pore complex assembly (GO:0051292)2.98076557
113chromatin assembly or disassembly (GO:0006333)2.97969667
114SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.97825245
115UTP metabolic process (GO:0046051)2.97762914
116histone exchange (GO:0043486)2.97432948
117negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.97358091
118CTP biosynthetic process (GO:0006241)2.95316579
119CTP metabolic process (GO:0046036)2.95316579
120regulation of telomere maintenance via telomerase (GO:0032210)2.94570453
121negative regulation of mRNA processing (GO:0050686)2.93842074
122regulation of histone H3-K9 methylation (GO:0051570)2.93268169
123spindle checkpoint (GO:0031577)2.93234075
124telomere organization (GO:0032200)2.92744550
125telomere maintenance (GO:0000723)2.92438573
126* base-excision repair (GO:0006284)2.91961086
127viral mRNA export from host cell nucleus (GO:0046784)2.91919365
128rRNA processing (GO:0006364)2.91817634
129IMP metabolic process (GO:0046040)2.90968831
130transcription-coupled nucleotide-excision repair (GO:0006283)2.90932972
131nuclear envelope organization (GO:0006998)2.89367520
132termination of RNA polymerase II transcription (GO:0006369)2.88982064
133protein targeting to ER (GO:0045047)2.87446102
134chromosome condensation (GO:0030261)2.87319972
135cotranslational protein targeting to membrane (GO:0006613)2.87319608
136mitotic spindle checkpoint (GO:0071174)2.86241840
137anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.85624864
138pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.84948998
139NADH dehydrogenase complex assembly (GO:0010257)2.84800400
140mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.84800400
141mitochondrial respiratory chain complex I assembly (GO:0032981)2.84800400
142pre-miRNA processing (GO:0031054)2.73859266
143negative regulation of DNA-templated transcription, elongation (GO:0032785)2.71908776
144protein complex biogenesis (GO:0070271)2.70797256
145establishment of protein localization to mitochondrial membrane (GO:0090151)2.70757593
146mitotic G1 DNA damage checkpoint (GO:0031571)2.66590389
147heterochromatin organization (GO:0070828)2.65506097
148intraciliary transport (GO:0042073)2.64365038
149epithelial cilium movement (GO:0003351)2.63864736
150negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.62917640
151left/right pattern formation (GO:0060972)2.62712217
152chromosome segregation (GO:0007059)2.62252762
153cellular component biogenesis (GO:0044085)2.61190801
154spliceosomal tri-snRNP complex assembly (GO:0000244)2.60158184
155mitochondrial respiratory chain complex assembly (GO:0033108)2.55591617
156dosage compensation (GO:0007549)2.54121047
157resolution of meiotic recombination intermediates (GO:0000712)2.52273292
158protein insertion into membrane (GO:0051205)2.52217387
159establishment of protein localization to membrane (GO:0090150)2.47206080
160spinal cord association neuron differentiation (GO:0021527)2.45814661
161mitotic G1/S transition checkpoint (GO:0044819)2.44124416
162positive regulation of viral transcription (GO:0050434)2.43313557

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.19452171
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.35431091
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.92074099
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.70757843
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.46788828
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.07647678
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.91666422
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.71240879
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.70386329
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.66014644
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.55693481
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.53501903
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.53396044
14* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.52457782
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.32096111
16XRN2_22483619_ChIP-Seq_HELA_Human2.30146339
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.29040321
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.29019327
19MYC_22102868_ChIP-Seq_BL_Human2.25016072
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.21326417
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19635026
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97804730
23CIITA_25753668_ChIP-Seq_RAJI_Human1.94814865
24* VDR_23849224_ChIP-Seq_CD4+_Human1.91586641
25AR_21909140_ChIP-Seq_LNCAP_Human1.91119558
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.90995040
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.85499517
28THAP11_20581084_ChIP-Seq_MESCs_Mouse1.82336739
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82295790
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.80357162
31FOXP3_21729870_ChIP-Seq_TREG_Human1.79904493
32* GABP_19822575_ChIP-Seq_HepG2_Human1.79458365
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77614429
34CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.77389368
35SRY_22984422_ChIP-ChIP_TESTIS_Rat1.71828933
36DCP1A_22483619_ChIP-Seq_HELA_Human1.70286083
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.69875987
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68104885
39TTF2_22483619_ChIP-Seq_HELA_Human1.66437425
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.64018509
41* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.62772367
42CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.60379913
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.58694466
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.58505355
45* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.57496113
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.56967928
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54909489
48* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53950163
49KDM5A_27292631_Chip-Seq_BREAST_Human1.53476003
50VDR_21846776_ChIP-Seq_THP-1_Human1.53327895
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53052100
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47375847
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43571170
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43417860
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42525892
56P68_20966046_ChIP-Seq_HELA_Human1.42433737
57HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.41506923
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.38953807
59LXR_22292898_ChIP-Seq_THP-1_Human1.37963025
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32852632
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.32658441
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32328054
63CTCF_18555785_ChIP-Seq_MESCs_Mouse1.31147372
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30406364
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28310539
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28202460
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27190507
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26145317
69KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26126437
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24858616
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.23333620
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22082301
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21898432
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19866507
75CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19025666
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.18356204
77CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.17609369
78TFEB_21752829_ChIP-Seq_HELA_Human1.16324532
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15792443
80BCL6_27268052_Chip-Seq_Bcells_Human1.15362879
81ELF1_20517297_ChIP-Seq_JURKAT_Human1.15280542
82KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14118816
83HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13853573
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13771278
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13585433
86ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12297361
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11660607
88* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.09649987
89SRF_21415370_ChIP-Seq_HL-1_Mouse1.06907851
90SA1_27219007_Chip-Seq_ERYTHROID_Human1.06420618
91E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06188472
92CTCF_26484167_Chip-Seq_Bcells_Mouse1.05848173
93* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05755649
94CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04754376
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.03976318
96ELK1_19687146_ChIP-ChIP_HELA_Human1.03652919
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02959993
98KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02734995
99NANOG_21062744_ChIP-ChIP_HESCs_Human1.01932646
100* PHF8_20622854_ChIP-Seq_HELA_Human1.00986124
101* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00155011
102PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98923849
103ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94701622
104RACK7_27058665_Chip-Seq_MCF-7_Human0.94682966
105ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93998867
106BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93961704
107* BCOR_27268052_Chip-Seq_Bcells_Human0.92471610
108* E2F1_20622854_ChIP-Seq_HELA_Human0.92102743
109* ELK3_25401928_ChIP-Seq_HUVEC_Human0.91950697
110CTCF_27219007_Chip-Seq_Bcells_Human0.90768788
111SOX2_16153702_ChIP-ChIP_HESCs_Human0.90328065
112ERG_21242973_ChIP-ChIP_JURKAT_Human0.89826422
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88424086
114RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.88055776
115DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86230963
116PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85582413
117SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85424461
118NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.83794996
119GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83256894
120TCF3_18692474_ChIP-Seq_MEFs_Mouse0.81826541
121SPI1_23547873_ChIP-Seq_NB4_Human0.80396828
122* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.80221716
123TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79772595
124* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.79573630
125ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79128114
126* FOXP1_21924763_ChIP-Seq_HESCs_Human0.76309206
127NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.76128143
128YY1_22570637_ChIP-Seq_MALME-3M_Human0.76017916

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.20940205
2MP0003111_abnormal_nucleus_morphology4.63893042
3MP0010094_abnormal_chromosome_stability4.56491828
4MP0004957_abnormal_blastocyst_morpholog4.13748793
5MP0003077_abnormal_cell_cycle3.97888331
6MP0009379_abnormal_foot_pigmentation3.82783408
7MP0008057_abnormal_DNA_replication3.44935057
8MP0008058_abnormal_DNA_repair3.05351940
9MP0008789_abnormal_olfactory_epithelium3.04049880
10MP0000566_synostosis3.00336329
11MP0005394_taste/olfaction_phenotype2.98362985
12MP0005499_abnormal_olfactory_system2.98362985
13MP0008007_abnormal_cellular_replicative2.71065210
14MP0003122_maternal_imprinting2.50965592
15MP0001730_embryonic_growth_arrest2.48190848
16MP0008932_abnormal_embryonic_tissue2.47685837
17MP0002249_abnormal_larynx_morphology2.30312328
18MP0003123_paternal_imprinting2.29646515
19MP0000350_abnormal_cell_proliferation2.25595452
20MP0002396_abnormal_hematopoietic_system2.17064625
21MP0002938_white_spotting2.12536058
22MP0003136_yellow_coat_color2.11486268
23MP0010352_gastrointestinal_tract_polyps1.92263886
24MP0005380_embryogenesis_phenotype1.89292492
25MP0001672_abnormal_embryogenesis/_devel1.89292492
26MP0003787_abnormal_imprinting1.86359895
27* MP0001697_abnormal_embryo_size1.82814003
28MP0003938_abnormal_ear_development1.78565042
29MP0008877_abnormal_DNA_methylation1.77408409
30* MP0002080_prenatal_lethality1.73229322
31MP0003786_premature_aging1.71954303
32* MP0002085_abnormal_embryonic_tissue1.71571509
33MP0010030_abnormal_orbit_morphology1.71217585
34MP0010307_abnormal_tumor_latency1.70372015
35MP0003984_embryonic_growth_retardation1.69403335
36MP0001529_abnormal_vocalization1.66521691
37MP0002088_abnormal_embryonic_growth/wei1.65911493
38MP0002653_abnormal_ependyma_morphology1.63394982
39MP0000490_abnormal_crypts_of1.60755648
40* MP0002084_abnormal_developmental_patter1.57489909
41MP0002102_abnormal_ear_morphology1.53879188
42MP0000313_abnormal_cell_death1.51672983
43MP0004197_abnormal_fetal_growth/weight/1.49815601
44MP0003942_abnormal_urinary_system1.48817797
45MP0009278_abnormal_bone_marrow1.47494936
46MP0002086_abnormal_extraembryonic_tissu1.45730031
47MP0004808_abnormal_hematopoietic_stem1.43025089
48MP0003119_abnormal_digestive_system1.38218443
49MP0002019_abnormal_tumor_incidence1.36934067
50MP0001293_anophthalmia1.35528149
51MP0002234_abnormal_pharynx_morphology1.31903004
52MP0002163_abnormal_gland_morphology1.28498764
53MP0003121_genomic_imprinting1.28488091
54MP0000537_abnormal_urethra_morphology1.28348197
55MP0003861_abnormal_nervous_system1.26794026
56MP0002233_abnormal_nose_morphology1.26586086
57MP0003283_abnormal_digestive_organ1.26083474
58MP0001545_abnormal_hematopoietic_system1.25955841
59MP0005397_hematopoietic_system_phenotyp1.25955841
60MP0003718_maternal_effect1.24517636
61MP0002210_abnormal_sex_determination1.24034970
62MP0003567_abnormal_fetal_cardiomyocyte1.22152268
63MP0000631_abnormal_neuroendocrine_gland1.22109556
64MP0009333_abnormal_splenocyte_physiolog1.21121955
65MP0005076_abnormal_cell_differentiation1.20122020
66MP0003890_abnormal_embryonic-extraembry1.19785388
67MP0000703_abnormal_thymus_morphology1.16903933
68MP0001849_ear_inflammation1.15832966
69MP0004133_heterotaxia1.15779416
70MP0001145_abnormal_male_reproductive1.12934641
71MP0001929_abnormal_gametogenesis1.12206990
72MP0000778_abnormal_nervous_system1.12016763
73MP0002822_catalepsy1.06943448
74MP0004142_abnormal_muscle_tone1.06672126
75MP0003763_abnormal_thymus_physiology1.06332618
76MP0002398_abnormal_bone_marrow1.05899331
77MP0002722_abnormal_immune_system1.05201437
78MP0002638_abnormal_pupillary_reflex1.04429519
79MP0003385_abnormal_body_wall1.03486435
80MP0009672_abnormal_birth_weight1.03287143
81MP0000689_abnormal_spleen_morphology1.02699089
82MP0008995_early_reproductive_senescence1.00105687
83MP0002116_abnormal_craniofacial_bone0.99557025
84MP0000428_abnormal_craniofacial_morphol0.98291735
85MP0000358_abnormal_cell_content/0.97875812
86MP0000955_abnormal_spinal_cord0.97108952
87MP0006054_spinal_hemorrhage0.93134817
88MP0006035_abnormal_mitochondrial_morpho0.92898063
89MP0002111_abnormal_tail_morphology0.92428652
90MP0000534_abnormal_ureter_morphology0.91638261
91MP0002697_abnormal_eye_size0.91489990
92MP0005083_abnormal_biliary_tract0.91281865
93MP0002277_abnormal_respiratory_mucosa0.91229588
94MP0003315_abnormal_perineum_morphology0.89601532
95MP0001346_abnormal_lacrimal_gland0.87039630
96MP0000653_abnormal_sex_gland0.86192761
97MP0002152_abnormal_brain_morphology0.85314022
98MP0005384_cellular_phenotype0.83769299
99MP0002429_abnormal_blood_cell0.83439631
100MP0002092_abnormal_eye_morphology0.82797549
101MP0001270_distended_abdomen0.82477661
102MP0002132_abnormal_respiratory_system0.80801970
103MP0006276_abnormal_autonomic_nervous0.80390610
104MP0003705_abnormal_hypodermis_morpholog0.79185689
105MP0006292_abnormal_olfactory_placode0.78487417
106MP0003878_abnormal_ear_physiology0.78387405
107MP0005377_hearing/vestibular/ear_phenot0.78387405
108MP0003755_abnormal_palate_morphology0.78015976
109MP0002160_abnormal_reproductive_system0.77506435
110MP0002282_abnormal_trachea_morphology0.76777768
111MP0002751_abnormal_autonomic_nervous0.76300381
112MP0000372_irregular_coat_pigmentation0.75993967
113MP0005621_abnormal_cell_physiology0.75940314
114MP0000026_abnormal_inner_ear0.75128988
115MP0005075_abnormal_melanosome_morpholog0.74790437
116MP0002752_abnormal_somatic_nervous0.73665949
117MP0009053_abnormal_anal_canal0.73425780
118MP0009703_decreased_birth_body0.73023547
119MP0000678_abnormal_parathyroid_gland0.72059955
120MP0003115_abnormal_respiratory_system0.71337301
121MP0002075_abnormal_coat/hair_pigmentati0.70108759
122MP0001915_intracranial_hemorrhage0.69090986
123MP0000733_abnormal_muscle_development0.69069343
124MP0003698_abnormal_male_reproductive0.67226434
125MP0000716_abnormal_immune_system0.66542755
126MP0005023_abnormal_wound_healing0.66118792
127MP0003566_abnormal_cell_adhesion0.65446252
128MP0002081_perinatal_lethality0.65303475
129MP0000371_diluted_coat_color0.64650748
130MP0000049_abnormal_middle_ear0.64556284
131MP0004264_abnormal_extraembryonic_tissu0.64395986
132MP0003937_abnormal_limbs/digits/tail_de0.64046983
133MP0002932_abnormal_joint_morphology0.63767749
134MP0000477_abnormal_intestine_morphology0.63553517
135MP0000685_abnormal_immune_system0.63104542
136MP0004233_abnormal_muscle_weight0.62528469
137MP0002127_abnormal_cardiovascular_syste0.62392359
138MP0008770_decreased_survivor_rate0.60303778
139MP0002269_muscular_atrophy0.60301786
140MP0001286_abnormal_eye_development0.60125847
141MP0005389_reproductive_system_phenotype0.59140529
142MP0003806_abnormal_nucleotide_metabolis0.58403889
143MP0002161_abnormal_fertility/fecundity0.57541854
144MP0002114_abnormal_axial_skeleton0.56228918

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.30473864
2Birth length less than 3rd percentile (HP:0003561)4.04407951
3Abnormality of cells of the erythroid lineage (HP:0012130)3.90637978
4Selective tooth agenesis (HP:0001592)3.86401965
5Reticulocytopenia (HP:0001896)3.75225331
6Abnormal number of erythroid precursors (HP:0012131)3.74664078
7Patellar aplasia (HP:0006443)3.52339156
8Breast hypoplasia (HP:0003187)3.51365104
9Broad distal phalanx of finger (HP:0009836)3.40201632
10Aplasia/Hypoplasia of the patella (HP:0006498)3.33305662
11Colon cancer (HP:0003003)3.29445943
12Medulloblastoma (HP:0002885)3.22282720
13Abnormality of the anterior horn cell (HP:0006802)3.18190371
14Degeneration of anterior horn cells (HP:0002398)3.18190371
15Oral leukoplakia (HP:0002745)3.17465743
16Optic nerve coloboma (HP:0000588)3.17213820
17Carpal bone hypoplasia (HP:0001498)3.16352570
18Abnormality of the aortic arch (HP:0012303)3.05504345
19Hypoplasia of the capital femoral epiphysis (HP:0003090)2.93919676
20Absent thumb (HP:0009777)2.80356664
21Abnormal mitochondria in muscle tissue (HP:0008316)2.80136469
22Impulsivity (HP:0100710)2.79658929
23Rough bone trabeculation (HP:0100670)2.77397931
24Cerebral hypomyelination (HP:0006808)2.75098320
25Meckel diverticulum (HP:0002245)2.73682744
26Acute necrotizing encephalopathy (HP:0006965)2.73662489
27Down-sloping shoulders (HP:0200021)2.67853343
28Macrocytic anemia (HP:0001972)2.66236209
29Abnormality of the ileum (HP:0001549)2.66080825
30Astrocytoma (HP:0009592)2.65011334
31Abnormality of the astrocytes (HP:0100707)2.65011334
32Partial duplication of thumb phalanx (HP:0009944)2.63436532
33Trismus (HP:0000211)2.61972748
34Basal cell carcinoma (HP:0002671)2.57709788
35Abnormality of DNA repair (HP:0003254)2.57551924
36Rhabdomyosarcoma (HP:0002859)2.56357039
37Absent radius (HP:0003974)2.49139002
38Multiple enchondromatosis (HP:0005701)2.48689005
39Chromosomal breakage induced by crosslinking agents (HP:0003221)2.46227778
40Neoplasm of the pancreas (HP:0002894)2.45310472
41Aplastic anemia (HP:0001915)2.44591669
42Abnormal number of incisors (HP:0011064)2.44228837
43Abnormality of the preputium (HP:0100587)2.44026503
44Agnosia (HP:0010524)2.41659874
45Duodenal stenosis (HP:0100867)2.40607436
46Small intestinal stenosis (HP:0012848)2.40607436
47Microretrognathia (HP:0000308)2.39930303
48Chromsome breakage (HP:0040012)2.38961559
49Aplasia/Hypoplasia of the uvula (HP:0010293)2.38823209
50Abnormal respiratory epithelium morphology (HP:0012253)2.38166147
51Abnormal respiratory motile cilium morphology (HP:0005938)2.38166147
52Anophthalmia (HP:0000528)2.37803551
53Pallor (HP:0000980)2.35126909
54Atresia of the external auditory canal (HP:0000413)2.34688675
55Acute encephalopathy (HP:0006846)2.33466151
56Abnormality of chromosome stability (HP:0003220)2.32663566
57Bilateral microphthalmos (HP:0007633)2.32295944
58Trigonocephaly (HP:0000243)2.32154490
59Neoplasm of striated muscle (HP:0009728)2.31696710
60Absent forearm bone (HP:0003953)2.30408059
61Aplasia involving forearm bones (HP:0009822)2.30408059
62Glioma (HP:0009733)2.29599738
63Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.29015673
64Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.28340259
65Absent epiphyses (HP:0010577)2.27704309
66Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.27704309
67Premature ovarian failure (HP:0008209)2.27531470
68Maternal diabetes (HP:0009800)2.27507478
69Supernumerary spleens (HP:0009799)2.25639948
70Myelodysplasia (HP:0002863)2.24312414
71Duplication of thumb phalanx (HP:0009942)2.24240579
72Abnormal respiratory motile cilium physiology (HP:0012261)2.23690778
73High anterior hairline (HP:0009890)2.21970802
74Mitochondrial inheritance (HP:0001427)2.21119445
75High pitched voice (HP:0001620)2.19668922
76Partial duplication of the phalanx of hand (HP:0009999)2.19138342
77Sloping forehead (HP:0000340)2.17981728
78Abnormal ciliary motility (HP:0012262)2.14535469
79Prominent nose (HP:0000448)2.11217639
80Aplasia/Hypoplasia of the sacrum (HP:0008517)2.11133466
81Increased nuchal translucency (HP:0010880)2.10524603
82Abnormal lung lobation (HP:0002101)2.08400623
83Premature graying of hair (HP:0002216)2.07973084
84Deep palmar crease (HP:0006191)2.07900395
85Bone marrow hypocellularity (HP:0005528)2.06641747
86Cafe-au-lait spot (HP:0000957)2.06409174
87Tracheoesophageal fistula (HP:0002575)2.06252030
8811 pairs of ribs (HP:0000878)2.05956215
89Cortical dysplasia (HP:0002539)2.05953538
90Abnormality of cochlea (HP:0000375)2.04105869
91Concave nail (HP:0001598)2.03017323
92Abnormality of the duodenum (HP:0002246)2.00429899
93Neoplasm of the oral cavity (HP:0100649)1.99711208
94Abnormality of the labia minora (HP:0012880)1.98272814
95Sleep apnea (HP:0010535)1.97200090
96Morphological abnormality of the inner ear (HP:0011390)1.96626976
97Thrombocytosis (HP:0001894)1.95372859
98Depressed nasal ridge (HP:0000457)1.94605017
99Short 4th metacarpal (HP:0010044)1.93771300
100Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.93771300
101Renal dysplasia (HP:0000110)1.92060139
102Holoprosencephaly (HP:0001360)1.91708679
103Septo-optic dysplasia (HP:0100842)1.91337947
104Personality changes (HP:0000751)1.91324514
105Adenoma sebaceum (HP:0009720)1.91033292
106Angiofibromas (HP:0010615)1.91033292
107Abnormality of B cell number (HP:0010975)1.90796022
108B lymphocytopenia (HP:0010976)1.90796022
109Facial cleft (HP:0002006)1.90575661
110Spinal muscular atrophy (HP:0007269)1.90515214
111Squamous cell carcinoma (HP:0002860)1.89426696
112Abnormality of the parietal bone (HP:0002696)1.89398017
113Rectal fistula (HP:0100590)1.89226242
114Rectovaginal fistula (HP:0000143)1.89226242
115Cellular immunodeficiency (HP:0005374)1.89129598
116Abnormal trabecular bone morphology (HP:0100671)1.88575236
117Ectopic kidney (HP:0000086)1.88436188
118Abnormality of the intervertebral disk (HP:0005108)1.87410652
119Intestinal fistula (HP:0100819)1.87008180
120Aplasia/Hypoplasia of the sternum (HP:0006714)1.86375861
121Triphalangeal thumb (HP:0001199)1.85705753
122Lymphoma (HP:0002665)1.85573029
123Cleft eyelid (HP:0000625)1.84783170
124Anencephaly (HP:0002323)1.83791719
125Atrophy/Degeneration involving motor neurons (HP:0007373)1.83767424
126Increased CSF lactate (HP:0002490)1.82777592
127Missing ribs (HP:0000921)1.82625303
128IgM deficiency (HP:0002850)1.82428352
129Abnormality of the umbilical cord (HP:0010881)1.82026331
130Abnormality of reticulocytes (HP:0004312)1.82014738
131Horseshoe kidney (HP:0000085)1.81267444
132Vaginal fistula (HP:0004320)1.80317036
133Abnormality of the carotid arteries (HP:0005344)1.79718456
134Rib fusion (HP:0000902)1.79553458
135Volvulus (HP:0002580)1.77122875
136Preaxial hand polydactyly (HP:0001177)1.76731289
137Small epiphyses (HP:0010585)1.76681815
138Slender long bone (HP:0003100)1.76388429
139Hyperthyroidism (HP:0000836)1.76325313
140Aplasia/hypoplasia of the humerus (HP:0006507)1.76169674
141Proximal placement of thumb (HP:0009623)1.75343636
142Absent/shortened dynein arms (HP:0200106)1.75249682
143Dynein arm defect of respiratory motile cilia (HP:0012255)1.75249682
144Hyperacusis (HP:0010780)1.73962441
145Short thumb (HP:0009778)1.73343265
146Hemivertebrae (HP:0002937)1.72952094
147Hepatocellular necrosis (HP:0001404)1.72626294
148Broad phalanges of the hand (HP:0009768)1.71882439
149Abdominal situs inversus (HP:0003363)1.71673942
150Abnormality of abdominal situs (HP:0011620)1.71673942
151Rhinitis (HP:0012384)1.71670997
152Disproportionate short-trunk short stature (HP:0003521)1.71083429
153Progressive macrocephaly (HP:0004481)1.67387670
154Esophageal atresia (HP:0002032)1.67320365
155Hepatic necrosis (HP:0002605)1.66908567
156Abnormality of the phalanges of the hallux (HP:0010057)1.65138627
157Type I transferrin isoform profile (HP:0003642)1.64606262
158Hypoplasia of the pons (HP:0012110)1.64457282
159Supernumerary ribs (HP:0005815)1.64363505
160Sclerocornea (HP:0000647)1.63448204
161Broad finger (HP:0001500)1.63151919
162Broad thumb (HP:0011304)1.62790588
163Tetralogy of Fallot (HP:0001636)1.61956143
164Decreased activity of mitochondrial respiratory chain (HP:0008972)1.60900075
165Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.60900075
166Truncus arteriosus (HP:0001660)1.60462710
167Hyperglycinemia (HP:0002154)1.59916069
168Respiratory difficulties (HP:0002880)1.59036279

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.92516763
2VRK24.64822636
3WEE13.96561172
4CDC73.94457639
5NEK23.49320123
6SMG13.35079434
7TAF13.29152251
8MAP3K102.89388009
9MAP3K92.60554045
10NME12.50744398
11EEF2K2.46150857
12TTK2.44834042
13TSSK62.10644633
14PASK2.07836664
15CDK122.01869939
16EIF2AK11.94344990
17PLK11.92282727
18SRPK11.88293702
19DYRK31.88122211
20RPS6KB21.87638395
21NEK11.85779617
22DYRK21.79882195
23CDK71.73711599
24TLK11.71783308
25ATR1.65608798
26CAMK1D1.64684101
27STK101.59714953
28TESK21.58853151
29EPHA21.58547413
30CCNB11.57083818
31MAP4K11.56946239
32AURKB1.56939161
33BRSK21.56488699
34PLK41.54020826
35CDK41.52065175
36ACVR1B1.47375984
37MAP3K81.44944520
38SIK21.40861131
39PKN21.39378747
40SCYL21.39056701
41AURKA1.37993307
42EIF2AK31.37411829
43NME21.34864937
44VRK11.34802359
45BRSK11.32590237
46CAMK1G1.31711268
47EPHB21.30540599
48STK41.29032140
49RPS6KA41.26249226
50CHEK11.23168316
51PAK41.19265920
52SIK11.17702830
53* CHEK21.15392388
54CDK191.14499737
55TGFBR11.08980145
56ICK1.08900207
57MKNK11.06755254
58MAPK151.03943759
59STK161.01790549
60TRIB30.96775070
61MAP2K70.95135493
62MAP2K20.93805352
63MAP3K110.93579242
64BRD40.91267566
65GRK60.89841593
66PLK30.89181979
67* CDK20.88772165
68NTRK20.84610580
69LRRK20.82994708
70TESK10.82412195
71CSNK1G30.80663848
72ZAK0.80281226
73CSF1R0.79957753
74ATM0.77968799
75CLK10.76698221
76PIM10.76153669
77IRAK30.76081796
78IRAK20.75611328
79PRKCI0.75144216
80MTOR0.74011380
81ERN10.71140482
82CAMKK10.70671686
83FLT30.70118855
84PAK10.69914853
85AKT20.69373737
86CDK90.69110154
87CDK11A0.68754807
88MAPKAPK30.67232668
89MARK20.65950817
90MARK10.65160473
91MAP2K30.65158479
92MKNK20.64203221
93CDK10.63934661
94MARK30.61607091
95ALK0.61601084
96BCKDK0.60791085
97TAOK20.59923743
98MAP3K70.59419987
99CDK150.58651634
100* CSNK2A20.57482340
101KDR0.56423790
102RPS6KC10.56254349
103RPS6KL10.56254349
104CDK60.55432339
105DYRK1B0.54476157
106PDK30.53512516
107PDK40.53512516
108* CSNK2A10.53146599
109PRKD30.52465498
110BTK0.52117049
111CAMK10.51603914
112CDK180.51089091
113CDK140.50530930
114BRAF0.49741444
115CDK30.49641287
116STK30.49198010
117MELK0.44263992
118SIK30.43146002
119RPS6KA10.42665420
120RPS6KA60.42319628
121UHMK10.40766055
122WNK30.40532996
123RPS6KA20.40518282
124ILK0.37572691
125MAPK110.36683540
126PRKD20.36043020
127RPS6KA50.35434345
128FGFR20.34746173
129PIM20.33704961
130CSNK1E0.31376177
131EIF2AK20.30827857
132MAP3K30.30093219
133ZAP700.28854912
134PAK20.28277292
135* PRKDC0.28176619
136CDK80.26169947
137BMX0.24817716
138PNCK0.24106912
139TAOK10.21992861
140MAPK140.20975690
141MAPK10.20630130
142AKT10.19131601

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.18025730
2Mismatch repair_Homo sapiens_hsa034304.40244076
3Spliceosome_Homo sapiens_hsa030403.48116161
4* Base excision repair_Homo sapiens_hsa034103.34062130
5Ribosome_Homo sapiens_hsa030103.19907176
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.10025713
7RNA transport_Homo sapiens_hsa030133.04911171
8Homologous recombination_Homo sapiens_hsa034402.91329384
9Nucleotide excision repair_Homo sapiens_hsa034202.80382322
10Cell cycle_Homo sapiens_hsa041102.78113859
11Proteasome_Homo sapiens_hsa030502.68585816
12RNA polymerase_Homo sapiens_hsa030202.63906076
13One carbon pool by folate_Homo sapiens_hsa006702.62067200
14Oxidative phosphorylation_Homo sapiens_hsa001902.59018441
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.57219213
16Parkinsons disease_Homo sapiens_hsa050122.48721187
17Pyrimidine metabolism_Homo sapiens_hsa002402.27160712
18Fanconi anemia pathway_Homo sapiens_hsa034602.12960169
19Non-homologous end-joining_Homo sapiens_hsa034502.03497298
20mRNA surveillance pathway_Homo sapiens_hsa030151.86301553
21Basal transcription factors_Homo sapiens_hsa030221.66624194
22RNA degradation_Homo sapiens_hsa030181.63911572
23p53 signaling pathway_Homo sapiens_hsa041151.57977288
24Alzheimers disease_Homo sapiens_hsa050101.37757107
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.29672946
26Systemic lupus erythematosus_Homo sapiens_hsa053221.26546215
27Selenocompound metabolism_Homo sapiens_hsa004501.20356926
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20194611
29Epstein-Barr virus infection_Homo sapiens_hsa051691.19386746
30Purine metabolism_Homo sapiens_hsa002301.18588870
31Vitamin B6 metabolism_Homo sapiens_hsa007501.17799417
32Cardiac muscle contraction_Homo sapiens_hsa042601.14324649
33Folate biosynthesis_Homo sapiens_hsa007901.06510500
34Biosynthesis of amino acids_Homo sapiens_hsa012301.03460539
35Primary immunodeficiency_Homo sapiens_hsa053401.02768413
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02277471
37Viral carcinogenesis_Homo sapiens_hsa052031.01714260
38Antigen processing and presentation_Homo sapiens_hsa046121.00657611
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00003664
40Sulfur relay system_Homo sapiens_hsa041220.99904215
41Pentose phosphate pathway_Homo sapiens_hsa000300.95916429
42Oocyte meiosis_Homo sapiens_hsa041140.95199101
43Steroid biosynthesis_Homo sapiens_hsa001000.94003545
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89131850
45HTLV-I infection_Homo sapiens_hsa051660.87588489
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85974308
47Herpes simplex infection_Homo sapiens_hsa051680.84218197
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.82049191
49Fatty acid elongation_Homo sapiens_hsa000620.81937150
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.75371959
51Fructose and mannose metabolism_Homo sapiens_hsa000510.74611153
52Notch signaling pathway_Homo sapiens_hsa043300.72365427
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69637396
54Basal cell carcinoma_Homo sapiens_hsa052170.69087190
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68844908
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67103003
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65860263
58Small cell lung cancer_Homo sapiens_hsa052220.64135171
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63406974
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.61357194
61MicroRNAs in cancer_Homo sapiens_hsa052060.61310696
62N-Glycan biosynthesis_Homo sapiens_hsa005100.59935943
63Carbon metabolism_Homo sapiens_hsa012000.58402851
64Pyruvate metabolism_Homo sapiens_hsa006200.56535261
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.56259713
66Thyroid cancer_Homo sapiens_hsa052160.55823452
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54920469
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54063361
69Hippo signaling pathway_Homo sapiens_hsa043900.53993131
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53225386
71Galactose metabolism_Homo sapiens_hsa000520.52753542
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51630898
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50743376
74Collecting duct acid secretion_Homo sapiens_hsa049660.50350010
75Bladder cancer_Homo sapiens_hsa052190.48980689
76Alcoholism_Homo sapiens_hsa050340.48375360
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48243866
78Hedgehog signaling pathway_Homo sapiens_hsa043400.47730960
79Protein export_Homo sapiens_hsa030600.46597454
80Chronic myeloid leukemia_Homo sapiens_hsa052200.46530904
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44340948
82B cell receptor signaling pathway_Homo sapiens_hsa046620.44266375
83Apoptosis_Homo sapiens_hsa042100.43563691
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42643999
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.42627560
86Legionellosis_Homo sapiens_hsa051340.42116685
87Colorectal cancer_Homo sapiens_hsa052100.40185914
88Renin-angiotensin system_Homo sapiens_hsa046140.40000598
89Vibrio cholerae infection_Homo sapiens_hsa051100.39369811
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37207990
91Lysine degradation_Homo sapiens_hsa003100.35960046
92Shigellosis_Homo sapiens_hsa051310.35427212
93Endometrial cancer_Homo sapiens_hsa052130.34955802
94Axon guidance_Homo sapiens_hsa043600.34924215
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34478796
96Acute myeloid leukemia_Homo sapiens_hsa052210.33031171
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33028105
98Cocaine addiction_Homo sapiens_hsa050300.32443636
99mTOR signaling pathway_Homo sapiens_hsa041500.31419125
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29821974
101Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28020789
102TGF-beta signaling pathway_Homo sapiens_hsa043500.27696447
103HIF-1 signaling pathway_Homo sapiens_hsa040660.27469266
104Pathways in cancer_Homo sapiens_hsa052000.27163025
105Glutathione metabolism_Homo sapiens_hsa004800.27120629
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26700592
107Hepatitis B_Homo sapiens_hsa051610.26347197
108Non-small cell lung cancer_Homo sapiens_hsa052230.25514334
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24386961
110NF-kappa B signaling pathway_Homo sapiens_hsa040640.23388658
111Synaptic vesicle cycle_Homo sapiens_hsa047210.22984728
112AMPK signaling pathway_Homo sapiens_hsa041520.22774912
113Pancreatic cancer_Homo sapiens_hsa052120.22418311
114Huntingtons disease_Homo sapiens_hsa050160.21150501
115Measles_Homo sapiens_hsa051620.20537974
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.20434117
117beta-Alanine metabolism_Homo sapiens_hsa004100.19392490
118Melanogenesis_Homo sapiens_hsa049160.19136481
119Arginine and proline metabolism_Homo sapiens_hsa003300.18515135
120Melanoma_Homo sapiens_hsa052180.15669015
121Adherens junction_Homo sapiens_hsa045200.14841915
122Metabolic pathways_Homo sapiens_hsa011000.13288734
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.12958167
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.12796670
125Wnt signaling pathway_Homo sapiens_hsa043100.12556088
126Influenza A_Homo sapiens_hsa051640.12236209
127Prostate cancer_Homo sapiens_hsa052150.11986565
128Glycosaminoglycan degradation_Homo sapiens_hsa005310.10380898
129Viral myocarditis_Homo sapiens_hsa054160.09852191
130Regulation of autophagy_Homo sapiens_hsa041400.09778936

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