XRCC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)4.90978002
2DNA replication initiation (GO:0006270)4.84501527
3DNA unwinding involved in DNA replication (GO:0006268)4.79011266
4DNA strand elongation (GO:0022616)4.71288489
5nuclear pore organization (GO:0006999)4.54580060
6telomere maintenance via semi-conservative replication (GO:0032201)4.44536497
7nuclear pore complex assembly (GO:0051292)4.44185020
8replication fork processing (GO:0031297)4.38082377
9protein localization to kinetochore (GO:0034501)4.25674266
10mitotic chromosome condensation (GO:0007076)4.23744864
11CENP-A containing nucleosome assembly (GO:0034080)4.19662189
12chromatin remodeling at centromere (GO:0031055)4.17992875
13DNA double-strand break processing (GO:0000729)4.13213632
14DNA replication checkpoint (GO:0000076)4.03865725
15telomere maintenance via recombination (GO:0000722)4.03310960
16mitotic metaphase plate congression (GO:0007080)3.95487367
17mitotic nuclear envelope disassembly (GO:0007077)3.94902457
18mitotic recombination (GO:0006312)3.93089690
19regulation of DNA endoreduplication (GO:0032875)3.91663851
20negative regulation of DNA-dependent DNA replication (GO:2000104)3.88931260
21kinetochore organization (GO:0051383)3.86751103
22nucleobase biosynthetic process (GO:0046112)3.84436910
23somatic diversification of immune receptors via somatic mutation (GO:0002566)3.82648169
24somatic hypermutation of immunoglobulin genes (GO:0016446)3.82648169
25mismatch repair (GO:0006298)3.82086102
26mitotic sister chromatid segregation (GO:0000070)3.81249006
27microtubule depolymerization (GO:0007019)3.81139995
28histone exchange (GO:0043486)3.79750980
29protein localization to chromosome, centromeric region (GO:0071459)3.76108416
30purine nucleobase biosynthetic process (GO:0009113)3.76054396
31DNA replication-independent nucleosome organization (GO:0034724)3.71264576
32DNA replication-independent nucleosome assembly (GO:0006336)3.71264576
33protein K6-linked ubiquitination (GO:0085020)3.71007987
34telomere maintenance via telomere lengthening (GO:0010833)3.70980156
35meiotic chromosome segregation (GO:0045132)3.70034344
36metaphase plate congression (GO:0051310)3.69554808
37DNA replication-dependent nucleosome assembly (GO:0006335)3.69443526
38DNA replication-dependent nucleosome organization (GO:0034723)3.69443526
39* recombinational repair (GO:0000725)3.67123505
40translesion synthesis (GO:0019985)3.67070729
41* double-strand break repair via homologous recombination (GO:0000724)3.67028817
42nuclear envelope disassembly (GO:0051081)3.62993246
43membrane disassembly (GO:0030397)3.62993246
44sister chromatid segregation (GO:0000819)3.60898457
45IMP biosynthetic process (GO:0006188)3.60286174
46pore complex assembly (GO:0046931)3.57341609
47regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.57297688
48piRNA metabolic process (GO:0034587)3.53510024
49DNA topological change (GO:0006265)3.50947632
50monoubiquitinated protein deubiquitination (GO:0035520)3.50186169
51centriole replication (GO:0007099)3.50041441
52pre-miRNA processing (GO:0031054)3.49969662
53postreplication repair (GO:0006301)3.49415552
54establishment of chromosome localization (GO:0051303)3.48468125
55nucleotide-excision repair, DNA gap filling (GO:0006297)3.47649240
56regulation of centrosome duplication (GO:0010824)3.43695914
57DNA geometric change (GO:0032392)3.41326767
58DNA duplex unwinding (GO:0032508)3.40944002
59regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.37561169
60regulation of posttranscriptional gene silencing (GO:0060147)3.36578095
61regulation of gene silencing by miRNA (GO:0060964)3.36578095
62regulation of gene silencing by RNA (GO:0060966)3.36578095
63mitotic sister chromatid cohesion (GO:0007064)3.36257522
64reciprocal meiotic recombination (GO:0007131)3.35214047
65reciprocal DNA recombination (GO:0035825)3.35214047
66regulation of spindle organization (GO:0090224)3.34373922
67attachment of spindle microtubules to kinetochore (GO:0008608)3.32248600
68kinetochore assembly (GO:0051382)3.30435973
69double-strand break repair via nonhomologous end joining (GO:0006303)3.28060363
70non-recombinational repair (GO:0000726)3.28060363
71regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.23989029
72regulation of mitotic spindle checkpoint (GO:1903504)3.23989029
73signal peptide processing (GO:0006465)3.23855565
74synapsis (GO:0007129)3.22150822
75regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.21966667
76folic acid-containing compound biosynthetic process (GO:0009396)3.19964595
77DNA conformation change (GO:0071103)3.19161457
78regulation of histone H3-K9 methylation (GO:0051570)3.18269998
79regulation of centrosome cycle (GO:0046605)3.17894739
80spindle checkpoint (GO:0031577)3.16374541
81telomere maintenance (GO:0000723)3.15447954
82telomere organization (GO:0032200)3.15241657
83intra-S DNA damage checkpoint (GO:0031573)3.14360765
84spindle assembly checkpoint (GO:0071173)3.13905432
85negative regulation of chromosome segregation (GO:0051985)3.13464279
86negative regulation of sister chromatid segregation (GO:0033046)3.13346206
87negative regulation of mitotic sister chromatid separation (GO:2000816)3.13346206
88negative regulation of mitotic sister chromatid segregation (GO:0033048)3.13346206
89negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.13346206
90chromosome segregation (GO:0007059)3.12577965
91regulation of centriole replication (GO:0046599)3.12223394
92IMP metabolic process (GO:0046040)3.11215594
93kynurenine metabolic process (GO:0070189)3.10275494
94viral mRNA export from host cell nucleus (GO:0046784)3.10128489
95regulation of chromosome segregation (GO:0051983)3.07694864
96negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.05828241
97chromatin assembly or disassembly (GO:0006333)3.05460133
98regulation of mitotic metaphase/anaphase transition (GO:0030071)3.05145518
99mitotic spindle assembly checkpoint (GO:0007094)3.04627411
100regulation of hippo signaling (GO:0035330)3.03112487
101ATP-dependent chromatin remodeling (GO:0043044)3.02291595
102regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.99522561
103regulation of nuclear cell cycle DNA replication (GO:0033262)2.97874342
104mRNA cleavage (GO:0006379)2.96274420
105mitotic spindle checkpoint (GO:0071174)2.95535030
106DNA packaging (GO:0006323)2.94995297
107histone H2A acetylation (GO:0043968)2.94846108
108ribosome assembly (GO:0042255)2.93993573
109ribosome biogenesis (GO:0042254)2.93839000
110prenylation (GO:0097354)2.93728412
111protein prenylation (GO:0018342)2.93728412
112gene silencing by RNA (GO:0031047)2.93073532
113sister chromatid cohesion (GO:0007062)2.92751895
114neural tube formation (GO:0001841)2.92348341
115maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.91171930
116indole-containing compound catabolic process (GO:0042436)2.91119013
117indolalkylamine catabolic process (GO:0046218)2.91119013
118tryptophan catabolic process (GO:0006569)2.91119013
119mRNA export from nucleus (GO:0006406)2.90931344
120negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.90633783
121negative regulation of translation, ncRNA-mediated (GO:0040033)2.90633783
122regulation of translation, ncRNA-mediated (GO:0045974)2.90633783
123RNA export from nucleus (GO:0006405)2.90211270
124DNA synthesis involved in DNA repair (GO:0000731)2.90206193
125chromosome condensation (GO:0030261)2.90196640
126DNA strand renaturation (GO:0000733)2.90121382
127detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.89311106
128* centrosome organization (GO:0051297)2.89215306
129* double-strand break repair (GO:0006302)2.89098836
130regulation of double-strand break repair via homologous recombination (GO:0010569)2.88316959
131regulation of mitotic sister chromatid separation (GO:0010965)2.87678874
132regulation of mitotic sister chromatid segregation (GO:0033047)2.87678874
133regulation of sister chromatid segregation (GO:0033045)2.87678874
134microtubule anchoring (GO:0034453)2.87614077
135protein localization to chromosome (GO:0034502)2.87410109
136negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.87025185
137DNA replication (GO:0006260)2.86733434
138RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.85739752
139protein K11-linked deubiquitination (GO:0035871)2.85670070
140behavioral response to nicotine (GO:0035095)2.85380340
141snRNA transcription (GO:0009301)2.84059731
142* DNA recombination (GO:0006310)2.83786807
143indolalkylamine metabolic process (GO:0006586)2.82473775
144microtubule polymerization or depolymerization (GO:0031109)2.82246095
145* microtubule organizing center organization (GO:0031023)2.78510100
146resolution of meiotic recombination intermediates (GO:0000712)2.75138639
147centrosome duplication (GO:0051298)2.73909761

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.89304302
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.32148134
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.99910458
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.59744564
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.54267142
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.85643937
7ZNF274_21170338_ChIP-Seq_K562_Hela2.81444235
8VDR_22108803_ChIP-Seq_LS180_Human2.67552049
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.66518004
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.54541776
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.52341527
12EWS_26573619_Chip-Seq_HEK293_Human2.52040419
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.51308369
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.46694563
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.46604687
16* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.42177835
17IGF1R_20145208_ChIP-Seq_DFB_Human2.41072280
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.33896564
19* E2F1_21310950_ChIP-Seq_MCF-7_Human2.29943784
20AR_21909140_ChIP-Seq_LNCAP_Human2.29571067
21* FUS_26573619_Chip-Seq_HEK293_Human2.28735494
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.27677119
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.25796830
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.25010723
25GBX2_23144817_ChIP-Seq_PC3_Human2.23855208
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.22974345
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.21934448
28KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.18602190
29* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.15900943
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.14656614
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.10320446
32TAF15_26573619_Chip-Seq_HEK293_Human2.07554106
33VDR_23849224_ChIP-Seq_CD4+_Human2.07435023
34MYCN_18555785_ChIP-Seq_MESCs_Mouse2.07391985
35ETS1_20019798_ChIP-Seq_JURKAT_Human2.00970278
36E2F7_22180533_ChIP-Seq_HELA_Human10.4869429
37* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98460994
38FOXP3_21729870_ChIP-Seq_TREG_Human1.97702374
39XRN2_22483619_ChIP-Seq_HELA_Human1.93746358
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.89461006
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87210955
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86520540
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85477552
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.85460451
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85103787
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.84339665
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.76529020
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.75222197
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73754459
50* GABP_19822575_ChIP-Seq_HepG2_Human1.71731376
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.70246236
52CIITA_25753668_ChIP-Seq_RAJI_Human1.69688995
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.68850864
54* P300_19829295_ChIP-Seq_ESCs_Human1.68219714
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.65256391
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63327808
57* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62933243
58DCP1A_22483619_ChIP-Seq_HELA_Human1.62176560
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61716662
60ELK1_19687146_ChIP-ChIP_HELA_Human1.59834167
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.59191907
62ER_23166858_ChIP-Seq_MCF-7_Human1.58087855
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56676977
64TTF2_22483619_ChIP-Seq_HELA_Human1.54583670
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52927017
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.52536613
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49814141
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48918409
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47263828
70STAT3_23295773_ChIP-Seq_U87_Human1.45633250
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.45572808
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42561483
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42098340
74KDM5A_27292631_Chip-Seq_BREAST_Human1.41345909
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.39596466
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.39218760
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37235928
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.36904127
79ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34803742
80SRF_21415370_ChIP-Seq_HL-1_Mouse1.34500856
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34084344
82* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.32247711
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31353274
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28704396
85MYC_22102868_ChIP-Seq_BL_Human1.28246823
86CBP_20019798_ChIP-Seq_JUKART_Human1.27354055
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27354055
88RBPJ_22232070_ChIP-Seq_NCS_Mouse1.26878728
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.26322566
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26080270
91TCF4_23295773_ChIP-Seq_U87_Human1.25357669
92FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23869964
93RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22134254
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21304840
95SMAD4_21799915_ChIP-Seq_A2780_Human1.20605035
96CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20176180
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20127786
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19454752
99TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18911994
100SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16506734
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.13583076
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13119537
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13119537
104TFEB_21752829_ChIP-Seq_HELA_Human1.13101260
105SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11977401
106KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10835457
107TP53_22573176_ChIP-Seq_HFKS_Human1.09705941
108PIAS1_25552417_ChIP-Seq_VCAP_Human1.09169039
109GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08780463
110KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07951568
111POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04729235
112SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04445822
113CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03581481
114CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02928280
115NFE2_27457419_Chip-Seq_LIVER_Mouse1.02519371
116SMAD3_21741376_ChIP-Seq_EPCs_Human1.01293176
117SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01280084
118POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01080033
119TCF4_22108803_ChIP-Seq_LS180_Human0.99758159
120SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.99276599
121SALL1_21062744_ChIP-ChIP_HESCs_Human0.99013422
122BCAT_22108803_ChIP-Seq_LS180_Human0.98085215
123PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97534074
124AR_21572438_ChIP-Seq_LNCaP_Human0.96325344
125NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95616835
126AR_25329375_ChIP-Seq_VCAP_Human0.94806503
127* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94782137
128ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93773068
129NANOG_19829295_ChIP-Seq_ESCs_Human0.93757710
130SOX2_19829295_ChIP-Seq_ESCs_Human0.93757710
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92939310
132RUNX2_22187159_ChIP-Seq_PCA_Human0.92144374
133GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91967222
134PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91515026
135MYC_18940864_ChIP-ChIP_HL60_Human0.91382277
136PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91016521
137TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90883149
138DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89502090
139FLI1_21867929_ChIP-Seq_TH2_Mouse0.89269444
140CRX_20693478_ChIP-Seq_RETINA_Mouse0.88639409
141NANOG_18555785_Chip-Seq_ESCs_Mouse0.85458282
142OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84934412
143CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84895972
144SOX9_26525672_Chip-Seq_HEART_Mouse0.84331112
145PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84318219
146* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82256178
147IRF1_19129219_ChIP-ChIP_H3396_Human0.81906392
148IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.75518665
149E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.75496546
150VDR_21846776_ChIP-Seq_THP-1_Human0.75339982
151MYB_21317192_ChIP-Seq_ERMYB_Mouse0.74989701
152SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.74237927
153BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.73686723
154SPI1_23547873_ChIP-Seq_NB4_Human0.73169460
155NANOG_21062744_ChIP-ChIP_HESCs_Human0.73061207
156NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.67876002
157CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.66875948
158POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.65453002
159KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.64666947
160STAT3_1855785_ChIP-Seq_MESCs_Mouse0.64195572
161RUNX1_22412390_ChIP-Seq_EML_Mouse0.63345719
162FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.62885927
163SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.61767703

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0010094_abnormal_chromosome_stability5.06880787
2MP0003111_abnormal_nucleus_morphology4.35614762
3MP0003693_abnormal_embryo_hatching4.34658817
4MP0008057_abnormal_DNA_replication4.16139125
5MP0008058_abnormal_DNA_repair4.05663764
6MP0003077_abnormal_cell_cycle3.73058606
7MP0004957_abnormal_blastocyst_morpholog3.40090773
8MP0008877_abnormal_DNA_methylation3.16466212
9MP0008007_abnormal_cellular_replicative3.10324961
10MP0002396_abnormal_hematopoietic_system3.09916728
11MP0004808_abnormal_hematopoietic_stem2.45220668
12MP0000569_abnormal_digit_pigmentation2.42563148
13MP0010307_abnormal_tumor_latency2.24906403
14MP0008932_abnormal_embryonic_tissue2.22582302
15MP0003123_paternal_imprinting2.05018550
16MP0000350_abnormal_cell_proliferation2.01703828
17MP0003786_premature_aging2.00686989
18MP0003136_yellow_coat_color1.93070779
19MP0002938_white_spotting1.87397074
20MP0010352_gastrointestinal_tract_polyps1.86913514
21MP0001730_embryonic_growth_arrest1.86688107
22MP0001986_abnormal_taste_sensitivity1.85209907
23MP0000490_abnormal_crypts_of1.77059953
24MP0002210_abnormal_sex_determination1.75832211
25MP0005551_abnormal_eye_electrophysiolog1.70409025
26MP0001929_abnormal_gametogenesis1.69159239
27* MP0005380_embryogenesis_phenotype1.69042767
28* MP0001672_abnormal_embryogenesis/_devel1.69042767
29MP0003121_genomic_imprinting1.65241644
30MP0003195_calcinosis1.64760645
31MP0000427_abnormal_hair_cycle1.60848376
32MP0006292_abnormal_olfactory_placode1.59649523
33* MP0001697_abnormal_embryo_size1.56012148
34MP0000372_irregular_coat_pigmentation1.55537248
35* MP0003984_embryonic_growth_retardation1.53354029
36MP0006072_abnormal_retinal_apoptosis1.50410061
37MP0000015_abnormal_ear_pigmentation1.50359185
38MP0001145_abnormal_male_reproductive1.49644241
39* MP0002088_abnormal_embryonic_growth/wei1.47795330
40MP0005253_abnormal_eye_physiology1.42038677
41MP0001545_abnormal_hematopoietic_system1.40720111
42MP0005397_hematopoietic_system_phenotyp1.40720111
43* MP0000313_abnormal_cell_death1.37983479
44MP0004043_abnormal_pH_regulation1.37845423
45MP0003890_abnormal_embryonic-extraembry1.37806187
46* MP0002080_prenatal_lethality1.36623319
47MP0001293_anophthalmia1.36295885
48MP0000653_abnormal_sex_gland1.36119096
49MP0002019_abnormal_tumor_incidence1.33181380
50MP0003941_abnormal_skin_development1.32664675
51MP0002234_abnormal_pharynx_morphology1.32406102
52* MP0002085_abnormal_embryonic_tissue1.31715937
53MP0009046_muscle_twitch1.31462185
54MP0000631_abnormal_neuroendocrine_gland1.29479842
55MP0005174_abnormal_tail_pigmentation1.28198589
56MP0000383_abnormal_hair_follicle1.27039517
57MP0002736_abnormal_nociception_after1.26313660
58MP0002086_abnormal_extraembryonic_tissu1.23847654
59MP0004197_abnormal_fetal_growth/weight/1.21875613
60MP0000703_abnormal_thymus_morphology1.18551612
61MP0001968_abnormal_touch/_nociception1.18496598
62MP0005645_abnormal_hypothalamus_physiol1.17345967
63MP0005076_abnormal_cell_differentiation1.17070445
64MP0003787_abnormal_imprinting1.16594396
65MP0002398_abnormal_bone_marrow1.16540852
66* MP0002084_abnormal_developmental_patter1.16382944
67MP0003763_abnormal_thymus_physiology1.15592685
68MP0005409_darkened_coat_color1.14645711
69MP0003698_abnormal_male_reproductive1.14122478
70MP0003718_maternal_effect1.13434318
71MP0001485_abnormal_pinna_reflex1.11416505
72MP0005410_abnormal_fertilization1.10031328
73MP0000566_synostosis1.09504996
74MP0001119_abnormal_female_reproductive1.09063352
75MP0009333_abnormal_splenocyte_physiolog1.06695270
76MP0005646_abnormal_pituitary_gland1.06123455
77MP0002095_abnormal_skin_pigmentation1.05969658
78MP0002722_abnormal_immune_system1.01095517
79MP0006035_abnormal_mitochondrial_morpho1.01020039
80MP0000689_abnormal_spleen_morphology0.96826708
81MP0008872_abnormal_physiological_respon0.95545379
82MP0003646_muscle_fatigue0.93666544
83MP0006276_abnormal_autonomic_nervous0.92767218
84MP0002075_abnormal_coat/hair_pigmentati0.92209546
85MP0005391_vision/eye_phenotype0.90706429
86MP0001529_abnormal_vocalization0.90471148
87MP0005171_absent_coat_pigmentation0.89398122
88MP0005395_other_phenotype0.89245574
89MP0000358_abnormal_cell_content/0.88732348
90MP0003950_abnormal_plasma_membrane0.87942560
91MP0004147_increased_porphyrin_level0.86684499
92MP0006054_spinal_hemorrhage0.86002166
93MP0005266_abnormal_metabolism0.85742229
94MP0001286_abnormal_eye_development0.85228806
95MP0002160_abnormal_reproductive_system0.84301647
96MP0001915_intracranial_hemorrhage0.83901489
97MP0002429_abnormal_blood_cell0.83549706
98MP0005384_cellular_phenotype0.82080569
99MP0005187_abnormal_penis_morphology0.81230152
100MP0009697_abnormal_copulation0.81100662
101MP0002697_abnormal_eye_size0.79905693
102MP0002653_abnormal_ependyma_morphology0.78139928
103MP0009703_decreased_birth_body0.77939487
104MP0000647_abnormal_sebaceous_gland0.77514569
105MP0002837_dystrophic_cardiac_calcinosis0.77248582
106MP0002161_abnormal_fertility/fecundity0.76697078
107MP0002102_abnormal_ear_morphology0.76671565
108MP0005195_abnormal_posterior_eye0.74923384
109MP0002638_abnormal_pupillary_reflex0.74799938
110MP0002751_abnormal_autonomic_nervous0.74681624
111MP0002009_preneoplasia0.74509308
112MP0005075_abnormal_melanosome_morpholog0.74326435
113MP0001501_abnormal_sleep_pattern0.72254335
114MP0004133_heterotaxia0.72052309
115MP0002233_abnormal_nose_morphology0.71993041
116MP0005621_abnormal_cell_physiology0.71768108
117MP0001186_pigmentation_phenotype0.71315405
118MP0000858_altered_metastatic_potential0.70679287
119MP0000716_abnormal_immune_system0.70126270
120MP0004215_abnormal_myocardial_fiber0.70006349
121MP0001188_hyperpigmentation0.68643148
122MP0003567_abnormal_fetal_cardiomyocyte0.68537753
123MP0005389_reproductive_system_phenotype0.67576892
124MP0010678_abnormal_skin_adnexa0.67445809
125MP0009745_abnormal_behavioral_response0.67257005
126MP0001324_abnormal_eye_pigmentation0.67021167
127MP0009278_abnormal_bone_marrow0.66180655
128* MP0003861_abnormal_nervous_system0.65821714
129MP0002132_abnormal_respiratory_system0.65456970
130MP0005647_abnormal_sex_gland0.65196608
131MP0008770_decreased_survivor_rate0.64948410
132MP0004142_abnormal_muscle_tone0.64414108
133MP0009672_abnormal_birth_weight0.62611546
134MP0010030_abnormal_orbit_morphology0.61268885
135* MP0002111_abnormal_tail_morphology0.61061031
136MP0003943_abnormal_hepatobiliary_system0.58160206
137MP0002006_tumorigenesis0.57598188
138MP0003937_abnormal_limbs/digits/tail_de0.57544764
139MP0003119_abnormal_digestive_system0.57014536
140MP0003221_abnormal_cardiomyocyte_apopto0.55757006
141MP0002269_muscular_atrophy0.54842938
142MP0002114_abnormal_axial_skeleton0.53258260
143MP0003699_abnormal_female_reproductive0.52689079
144MP0003935_abnormal_craniofacial_develop0.50767185
145MP0008995_early_reproductive_senescence0.50737937
146MP0002405_respiratory_system_inflammati0.48440044
147MP0003656_abnormal_erythrocyte_physiolo0.47770612

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.43479728
2Birth length less than 3rd percentile (HP:0003561)4.37256890
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.27235542
4Elfin facies (HP:0004428)3.60774937
5Pancreatic cysts (HP:0001737)3.60247627
6Renovascular hypertension (HP:0100817)3.55072733
7Renal duplication (HP:0000075)3.51347934
8Increased nuchal translucency (HP:0010880)3.50656007
9Abnormality of chromosome stability (HP:0003220)3.50150263
10Hyperacusis (HP:0010780)3.35159760
11Pancreatic fibrosis (HP:0100732)3.29825784
12Medulloblastoma (HP:0002885)3.28069112
13Abnormality of the carotid arteries (HP:0005344)3.24904391
14Overriding aorta (HP:0002623)3.17653365
15Aplastic anemia (HP:0001915)3.09211172
16Aplasia/Hypoplasia of the uvula (HP:0010293)3.04312117
17Toxemia of pregnancy (HP:0100603)3.03401163
18Abnormality of the preputium (HP:0100587)3.02437780
19Meckel diverticulum (HP:0002245)2.99033038
20True hermaphroditism (HP:0010459)2.97323615
21Agnosia (HP:0010524)2.86672775
22Molar tooth sign on MRI (HP:0002419)2.81641778
23Abnormality of midbrain morphology (HP:0002418)2.81641778
24Myelodysplasia (HP:0002863)2.81336447
25Abnormality of the ileum (HP:0001549)2.79834059
26Flat cornea (HP:0007720)2.74006178
27Patellar aplasia (HP:0006443)2.69476628
28Sloping forehead (HP:0000340)2.69066513
29Ependymoma (HP:0002888)2.68011185
30Gaze-evoked nystagmus (HP:0000640)2.67933490
31Amaurosis fugax (HP:0100576)2.56710189
32Deep philtrum (HP:0002002)2.55413646
33Impulsivity (HP:0100710)2.54300485
34Protruding tongue (HP:0010808)2.53380613
35Ectopic kidney (HP:0000086)2.50762120
36Absent radius (HP:0003974)2.50422330
37Abnormality of the renal cortex (HP:0011035)2.46824479
38Hypoplasia of the pons (HP:0012110)2.46025367
3911 pairs of ribs (HP:0000878)2.45044313
40Aplasia/Hypoplasia of the patella (HP:0006498)2.44140451
41Abnormality of the diencephalon (HP:0010662)2.43405008
42Oral leukoplakia (HP:0002745)2.43141043
43Breast hypoplasia (HP:0003187)2.41374822
44Hyperventilation (HP:0002883)2.39532709
45Insomnia (HP:0100785)2.39075465
46Attenuation of retinal blood vessels (HP:0007843)2.37971947
47Absent forearm bone (HP:0003953)2.37962687
48Aplasia involving forearm bones (HP:0009822)2.37962687
49Aplasia/Hypoplasia of the tibia (HP:0005772)2.36836808
50Nephronophthisis (HP:0000090)2.36809089
51Bowel diverticulosis (HP:0005222)2.36391162
52Duodenal stenosis (HP:0100867)2.35810770
53Small intestinal stenosis (HP:0012848)2.35810770
54Abnormality of the pons (HP:0007361)2.35752696
55Degeneration of anterior horn cells (HP:0002398)2.35533133
56Abnormality of the anterior horn cell (HP:0006802)2.35533133
57Bone marrow hypocellularity (HP:0005528)2.35072470
58Abnormality of the renal collecting system (HP:0004742)2.34775589
59Abnormality of alanine metabolism (HP:0010916)2.32911699
60Hyperalaninemia (HP:0003348)2.32911699
61Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32911699
62Triphalangeal thumb (HP:0001199)2.32821248
63Central scotoma (HP:0000603)2.32769374
64Abnormal spermatogenesis (HP:0008669)2.32316400
65Chronic hepatic failure (HP:0100626)2.32315028
66Genetic anticipation (HP:0003743)2.30743288
67Thrombocytosis (HP:0001894)2.29881969
68Intestinal atresia (HP:0011100)2.29095346
69Selective tooth agenesis (HP:0001592)2.27342841
70Abnormal lung lobation (HP:0002101)2.27206642
71Cutaneous melanoma (HP:0012056)2.25210399
72Rhabdomyosarcoma (HP:0002859)2.24770466
73Long clavicles (HP:0000890)2.23318275
74Megalocornea (HP:0000485)2.22352792
75Cerebellar dysplasia (HP:0007033)2.22166697
76Aplasia/Hypoplasia of the sternum (HP:0006714)2.20847048
77Facial hemangioma (HP:0000329)2.19309212
78Abnormality of the renal medulla (HP:0100957)2.17968486
79Preaxial hand polydactyly (HP:0001177)2.17282318
80Cystic liver disease (HP:0006706)2.16074937
81Curly hair (HP:0002212)2.15991983
82Small hand (HP:0200055)2.14743260
83Sclerocornea (HP:0000647)2.13833439
84Irregular epiphyses (HP:0010582)2.12800270
85Tracheoesophageal fistula (HP:0002575)2.09370005
86Abnormality of the labia minora (HP:0012880)2.09049000
87Clubbing of toes (HP:0100760)2.09006664
88Cafe-au-lait spot (HP:0000957)2.08488690
89Reticulocytopenia (HP:0001896)2.06541086
90Medial flaring of the eyebrow (HP:0010747)2.04581035
91Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.04225697
92Short 4th metacarpal (HP:0010044)2.03730851
93Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.03730851
94Astigmatism (HP:0000483)2.03539033
95Hypoplasia of the capital femoral epiphysis (HP:0003090)2.03107396
96Aplasia/Hypoplasia of the tongue (HP:0010295)2.02892576
97Renal cortical cysts (HP:0000803)2.00607160
98Premature graying of hair (HP:0002216)1.95193532
99Embryonal renal neoplasm (HP:0011794)1.93305271
100Carpal bone hypoplasia (HP:0001498)1.93218519
101Abolished electroretinogram (ERG) (HP:0000550)1.92635557
102Colon cancer (HP:0003003)1.91545923
103Overlapping toe (HP:0001845)1.91187738
104Slender long bone (HP:0003100)1.90086589
105Supernumerary spleens (HP:0009799)1.90023351
106Duplicated collecting system (HP:0000081)1.90022273
107Postaxial foot polydactyly (HP:0001830)1.89322856
108Dandy-Walker malformation (HP:0001305)1.88904667
109Oligodactyly (hands) (HP:0001180)1.88822225
110Bony spicule pigmentary retinopathy (HP:0007737)1.88532257
111Abnormality of cochlea (HP:0000375)1.87839157
112Prominent nose (HP:0000448)1.85832259
113Basal cell carcinoma (HP:0002671)1.85832016
114Nephroblastoma (Wilms tumor) (HP:0002667)1.85253757
115Short thumb (HP:0009778)1.83819790
116Abnormal respiratory epithelium morphology (HP:0012253)1.82426006
117Abnormal respiratory motile cilium morphology (HP:0005938)1.82426006
118Progressive inability to walk (HP:0002505)1.80774348
119Optic nerve coloboma (HP:0000588)1.79931464
120Congenital primary aphakia (HP:0007707)1.79412473
121Absent thumb (HP:0009777)1.79346040
122Absent epiphyses (HP:0010577)1.79062212
123Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.79062212
124Abnormality of the duodenum (HP:0002246)1.79018333
125Anencephaly (HP:0002323)1.78916662
126Type II lissencephaly (HP:0007260)1.77994887
127Acute myeloid leukemia (HP:0004808)1.77964042
128Neoplasm of the pancreas (HP:0002894)1.77325820
129Deviation of the thumb (HP:0009603)1.77160142
130Scotoma (HP:0000575)1.76560326
131Volvulus (HP:0002580)1.76268713
132Oligohydramnios (HP:0001562)1.76033376
133Polygenic inheritance (HP:0010982)1.75611948
134Fair hair (HP:0002286)1.75421412
135Missing ribs (HP:0000921)1.74315053
136Pancytopenia (HP:0001876)1.74174735
137Neoplasm of the adrenal cortex (HP:0100641)1.73811618
138Squamous cell carcinoma (HP:0002860)1.73695231
139Acute lymphatic leukemia (HP:0006721)1.73320791
140Glioma (HP:0009733)1.73250565
141Pendular nystagmus (HP:0012043)1.71622402
142Highly arched eyebrow (HP:0002553)1.71032620
143Aganglionic megacolon (HP:0002251)1.70867110
144Astrocytoma (HP:0009592)1.70524033
145Abnormality of the astrocytes (HP:0100707)1.70524033
146Genital tract atresia (HP:0001827)1.69359527
147Abnormality of DNA repair (HP:0003254)1.69022320
148Proximal placement of thumb (HP:0009623)1.68214747
149Gait imbalance (HP:0002141)1.67901552
150Progressive cerebellar ataxia (HP:0002073)1.67674131
151Cellular immunodeficiency (HP:0005374)1.67566510
152Abnormal number of erythroid precursors (HP:0012131)1.67528538
153Preaxial foot polydactyly (HP:0001841)1.67335692
154Poor coordination (HP:0002370)1.67310987
155Congenital stationary night blindness (HP:0007642)1.65721019
156Lymphoma (HP:0002665)1.65540401
157Atresia of the external auditory canal (HP:0000413)1.65224920
158Congenital hepatic fibrosis (HP:0002612)1.65174674
159Gastrointestinal atresia (HP:0002589)1.64948498
160Bile duct proliferation (HP:0001408)1.64713338
161Abnormal biliary tract physiology (HP:0012439)1.64713338
162Abnormality of the fingertips (HP:0001211)1.63040677
163Obsessive-compulsive behavior (HP:0000722)1.62837769
164Lissencephaly (HP:0001339)1.62386963
165Bifid tongue (HP:0010297)1.62336065
166Vaginal atresia (HP:0000148)1.62045047
167Nephrogenic diabetes insipidus (HP:0009806)1.61954645
168Pancreatic islet-cell hyperplasia (HP:0004510)1.59775871
169Partial agenesis of the corpus callosum (HP:0001338)1.59742773

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.74552715
2CDC75.09025288
3WEE13.60422495
4BUB13.27254084
5BRSK22.84160167
6TSSK62.82328494
7NEK22.71883286
8ACVR1B2.54087731
9TTK2.46934247
10SRPK12.46533566
11NUAK12.45132174
12VRK12.30063993
13ATR2.28348922
14CCNB12.12216039
15EIF2AK12.07784073
16CDK72.02243239
17MKNK12.01987903
18PLK11.92253425
19PDK41.86455540
20PDK31.86455540
21ZAK1.81658306
22YES11.81268625
23PASK1.75882967
24PLK31.73146477
25CHEK21.72425986
26NEK11.72397957
27AURKB1.68949109
28WNK31.67797575
29ADRBK21.67476308
30STK41.67386096
31MAP4K21.67171988
32EIF2AK31.61923334
33PLK41.59011855
34BMPR1B1.47583989
35TAF11.46479969
36CDK121.46171340
37TGFBR11.44596146
38INSRR1.43104767
39MKNK21.40987579
40STK31.40789006
41BRSK11.39583395
42CHEK11.36672343
43PNCK1.35635336
44STK161.35093268
45AKT31.33559359
46VRK21.32233415
47RPS6KA41.31855007
48TRIM281.27372355
49DYRK31.22932731
50CDK41.20618073
51RPS6KB21.20000869
52TLK11.19206703
53FLT31.15710239
54EEF2K1.15637107
55TNIK1.15186970
56ATM1.11075177
57CLK11.10347240
58OXSR11.07715280
59MAP3K41.06960562
60BRD41.04148713
61CDK81.03674728
62STK391.02399219
63TYK21.00029153
64STK100.99482790
65PIM10.98053446
66AURKA0.95117319
67WNK40.93379882
68MAPK130.89725569
69SCYL20.88171241
70TESK10.87730259
71CDK20.81525034
72MAP3K80.80872124
73ERBB30.80331170
74RPS6KB10.78503868
75CASK0.78114530
76TAOK30.76591595
77PDK20.74221070
78MELK0.73423639
79PLK20.72509399
80CDK10.70455136
81BCR0.69063337
82CSNK1G10.68150953
83EIF2AK20.67818992
84NME10.67663013
85RPS6KA50.67345505
86BRAF0.66100535
87CAMK1G0.65605954
88PKN20.64001820
89PAK40.62547648
90NEK90.61796583
91CSNK1A1L0.61750939
92STK240.61424987
93BTK0.60033344
94MST40.59639237
95CDK60.57640245
96ADRBK10.56615100
97KIT0.54303306
98TEC0.53783820
99TESK20.52948779
100CSNK2A10.51339162
101CSNK1G30.49881359
102PIM20.49665506
103RPS6KC10.47410216
104RPS6KL10.47410216
105CSF1R0.47192684
106RPS6KA60.46227921
107CDK30.45993041
108CSNK1G20.45838867
109JAK30.45533753
110GRK10.45517926
111MAP4K10.44833519
112PAK10.44141051
113FGFR20.43306464
114EPHA20.43263097
115CSNK2A20.42386876
116MAPKAPK50.42130413
117CAMK1D0.41971340
118NME20.41865205
119MAP3K100.40172635
120CSNK1D0.40069804
121TXK0.39919950
122MAPKAPK20.38753302
123CSNK1E0.38622577
124PRKCG0.38191612
125RPS6KA20.34921685
126MAP2K70.34732991
127NLK0.34586132
128PRKCE0.34294527
129PBK0.34213416
130SGK20.33489812
131AKT20.33062914
132MTOR0.33046822
133GSK3B0.30160750
134PRKCI0.30025675
135AKT10.29600420
136PAK30.29544802
137PRKACB0.29515774
138ZAP700.29380115
139STK38L0.28402544
140PRKDC0.28224506
141CSNK1A10.27769380
142PINK10.27750035
143NTRK30.27223714
144PRKAA20.27082119
145LATS10.26769344

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.12197519
2Mismatch repair_Homo sapiens_hsa034304.57711244
3* Homologous recombination_Homo sapiens_hsa034403.35116931
4Base excision repair_Homo sapiens_hsa034103.34174023
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.30880491
6Cell cycle_Homo sapiens_hsa041103.07979398
7RNA transport_Homo sapiens_hsa030133.00958094
8Spliceosome_Homo sapiens_hsa030402.90205201
9Fanconi anemia pathway_Homo sapiens_hsa034602.86229616
10Nucleotide excision repair_Homo sapiens_hsa034202.78822906
11One carbon pool by folate_Homo sapiens_hsa006702.73667309
12RNA polymerase_Homo sapiens_hsa030202.46905594
13Non-homologous end-joining_Homo sapiens_hsa034502.41796206
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.39482693
15Basal transcription factors_Homo sapiens_hsa030222.22413277
16Pyrimidine metabolism_Homo sapiens_hsa002402.19267402
17RNA degradation_Homo sapiens_hsa030181.98948128
18mRNA surveillance pathway_Homo sapiens_hsa030151.98066225
19Proteasome_Homo sapiens_hsa030501.97708225
20Butanoate metabolism_Homo sapiens_hsa006501.81333277
21p53 signaling pathway_Homo sapiens_hsa041151.78744621
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70175061
23Propanoate metabolism_Homo sapiens_hsa006401.69390944
24Systemic lupus erythematosus_Homo sapiens_hsa053221.69245226
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52567185
26Nitrogen metabolism_Homo sapiens_hsa009101.42448347
27Purine metabolism_Homo sapiens_hsa002301.40257139
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39428408
29Ribosome_Homo sapiens_hsa030101.34247898
30Vitamin B6 metabolism_Homo sapiens_hsa007501.30694959
31Pentose phosphate pathway_Homo sapiens_hsa000301.29872021
32Herpes simplex infection_Homo sapiens_hsa051681.26794305
33Tryptophan metabolism_Homo sapiens_hsa003801.23987778
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16725088
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15878128
36Nicotine addiction_Homo sapiens_hsa050331.14808155
37Viral carcinogenesis_Homo sapiens_hsa052031.14100579
38Taste transduction_Homo sapiens_hsa047421.11960534
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08880092
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04393970
41Epstein-Barr virus infection_Homo sapiens_hsa051691.04135957
42Linoleic acid metabolism_Homo sapiens_hsa005911.03446981
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02337130
44Oocyte meiosis_Homo sapiens_hsa041141.00820501
45Olfactory transduction_Homo sapiens_hsa047400.97642683
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97596590
47Selenocompound metabolism_Homo sapiens_hsa004500.97100396
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96482332
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94270797
50ABC transporters_Homo sapiens_hsa020100.92020076
51Legionellosis_Homo sapiens_hsa051340.91747932
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.90800379
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90433898
54Antigen processing and presentation_Homo sapiens_hsa046120.86873756
55Phototransduction_Homo sapiens_hsa047440.85663374
56HTLV-I infection_Homo sapiens_hsa051660.82336880
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.80568051
58Ether lipid metabolism_Homo sapiens_hsa005650.80405492
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.77136126
60N-Glycan biosynthesis_Homo sapiens_hsa005100.76214962
61Alcoholism_Homo sapiens_hsa050340.75947702
62MicroRNAs in cancer_Homo sapiens_hsa052060.73741678
63Measles_Homo sapiens_hsa051620.73275140
64Biosynthesis of amino acids_Homo sapiens_hsa012300.72378631
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71820257
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71119664
67Thyroid cancer_Homo sapiens_hsa052160.67620466
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66501789
69Chronic myeloid leukemia_Homo sapiens_hsa052200.65900598
70Caffeine metabolism_Homo sapiens_hsa002320.64935681
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.64186889
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64167745
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63235206
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60625864
75Small cell lung cancer_Homo sapiens_hsa052220.59884972
76Pyruvate metabolism_Homo sapiens_hsa006200.59409432
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58178408
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57514624
79Retinol metabolism_Homo sapiens_hsa008300.57195640
80Huntingtons disease_Homo sapiens_hsa050160.57058999
81Viral myocarditis_Homo sapiens_hsa054160.56384475
82Morphine addiction_Homo sapiens_hsa050320.51538942
83Hepatitis B_Homo sapiens_hsa051610.51266420
84Steroid biosynthesis_Homo sapiens_hsa001000.51080141
85Glycerolipid metabolism_Homo sapiens_hsa005610.51014169
86Metabolic pathways_Homo sapiens_hsa011000.50942833
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50938531
88beta-Alanine metabolism_Homo sapiens_hsa004100.50012315
89Apoptosis_Homo sapiens_hsa042100.49966404
90Influenza A_Homo sapiens_hsa051640.47797069
91Colorectal cancer_Homo sapiens_hsa052100.47776136
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46501566
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46435352
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.44277447
95Fatty acid metabolism_Homo sapiens_hsa012120.44008352
96Folate biosynthesis_Homo sapiens_hsa007900.41972536
97Fatty acid biosynthesis_Homo sapiens_hsa000610.40306203
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40082035
99Hedgehog signaling pathway_Homo sapiens_hsa043400.40077999
100Carbon metabolism_Homo sapiens_hsa012000.39811920
101Primary immunodeficiency_Homo sapiens_hsa053400.39655717
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39432986
103Peroxisome_Homo sapiens_hsa041460.38214315
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37402905
105Chemical carcinogenesis_Homo sapiens_hsa052040.36959575
106Non-small cell lung cancer_Homo sapiens_hsa052230.36390094
107Shigellosis_Homo sapiens_hsa051310.35685329
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34985863
109Serotonergic synapse_Homo sapiens_hsa047260.34344808
110Basal cell carcinoma_Homo sapiens_hsa052170.32094926
111Ovarian steroidogenesis_Homo sapiens_hsa049130.31713061
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31391400
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30659990
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.30543891
115Fatty acid degradation_Homo sapiens_hsa000710.29969617
116Pathways in cancer_Homo sapiens_hsa052000.29390405
117Hippo signaling pathway_Homo sapiens_hsa043900.29257260
118Calcium signaling pathway_Homo sapiens_hsa040200.29100020
119TGF-beta signaling pathway_Homo sapiens_hsa043500.29012828
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27138999
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27126217
122Cyanoamino acid metabolism_Homo sapiens_hsa004600.26739143
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26371880
124Intestinal immune network for IgA production_Homo sapiens_hsa046720.26320656
125Glutamatergic synapse_Homo sapiens_hsa047240.25772350
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.25744730
127NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25591599
128Endometrial cancer_Homo sapiens_hsa052130.25353731
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25130162
130Parkinsons disease_Homo sapiens_hsa050120.24991859
131Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.24938651
132mTOR signaling pathway_Homo sapiens_hsa041500.24465617
133Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23496065
134Hematopoietic cell lineage_Homo sapiens_hsa046400.23459531
135Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23042537
136Notch signaling pathway_Homo sapiens_hsa043300.22309310
137HIF-1 signaling pathway_Homo sapiens_hsa040660.22148767
138Acute myeloid leukemia_Homo sapiens_hsa052210.21811620
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21256385
140Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21131852
141FoxO signaling pathway_Homo sapiens_hsa040680.20748149
142Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20231882
143Prostate cancer_Homo sapiens_hsa052150.19656906
144Central carbon metabolism in cancer_Homo sapiens_hsa052300.19057163
145Pancreatic cancer_Homo sapiens_hsa052120.18889036
146Lysine degradation_Homo sapiens_hsa003100.18055666
147Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17471553
148Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.17418218
149Toxoplasmosis_Homo sapiens_hsa051450.15379739
150Allograft rejection_Homo sapiens_hsa053300.14861942
151PI3K-Akt signaling pathway_Homo sapiens_hsa041510.14740842
152Melanoma_Homo sapiens_hsa052180.13689497
153Fructose and mannose metabolism_Homo sapiens_hsa000510.13633997
154Neurotrophin signaling pathway_Homo sapiens_hsa047220.11900895
155Protein export_Homo sapiens_hsa030600.11499941

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