XRCC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)6.21368492
2daunorubicin metabolic process (GO:0044597)5.12883961
3polyketide metabolic process (GO:0030638)5.12883961
4doxorubicin metabolic process (GO:0044598)5.12883961
5central nervous system myelination (GO:0022010)5.09241507
6axon ensheathment in central nervous system (GO:0032291)5.09241507
7mitotic chromosome condensation (GO:0007076)4.67898757
8peptidyl-arginine omega-N-methylation (GO:0035247)4.20399989
9nucleosome disassembly (GO:0006337)4.15121937
10protein-DNA complex disassembly (GO:0032986)4.15121937
11regulation of translational fidelity (GO:0006450)4.02945737
12proline biosynthetic process (GO:0006561)4.01071139
13heterochromatin organization (GO:0070828)4.01013313
14telomere maintenance via semi-conservative replication (GO:0032201)3.97030780
15DNA strand elongation involved in DNA replication (GO:0006271)3.94237865
16nuclear pore complex assembly (GO:0051292)3.93681740
17negative regulation of cell size (GO:0045792)3.93598729
18negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.91219461
19spliceosomal tri-snRNP complex assembly (GO:0000244)3.91203570
20DNA strand elongation (GO:0022616)3.85221322
21viral mRNA export from host cell nucleus (GO:0046784)3.79399645
22long-chain fatty acid biosynthetic process (GO:0042759)3.79364299
23DNA replication initiation (GO:0006270)3.78864962
24CENP-A containing nucleosome assembly (GO:0034080)3.69740045
25regulation of mammary gland epithelial cell proliferation (GO:0033599)3.68786276
26regulation of chromatin binding (GO:0035561)3.65734363
27deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.63528300
28DNA duplex unwinding (GO:0032508)3.63045220
29protein localization to chromosome, centromeric region (GO:0071459)3.61645334
30mitotic sister chromatid segregation (GO:0000070)3.61092648
31apoptotic process involved in morphogenesis (GO:0060561)3.61081209
32chromatin assembly (GO:0031497)3.60983265
33histone arginine methylation (GO:0034969)3.58667876
34DNA replication checkpoint (GO:0000076)3.56310039
35telomere maintenance via recombination (GO:0000722)3.54950440
36mitotic recombination (GO:0006312)3.54288319
37peptidyl-arginine methylation (GO:0018216)3.51019270
38peptidyl-arginine N-methylation (GO:0035246)3.51019270
39chromatin remodeling at centromere (GO:0031055)3.50612184
40DNA unwinding involved in DNA replication (GO:0006268)3.49267518
41mismatch repair (GO:0006298)3.47773504
42ribosomal small subunit biogenesis (GO:0042274)3.46943601
43regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.45850460
44DNA geometric change (GO:0032392)3.45131361
45snRNA metabolic process (GO:0016073)3.44106256
46folic acid metabolic process (GO:0046655)3.43800441
47preassembly of GPI anchor in ER membrane (GO:0016254)3.39637874
48kinetochore organization (GO:0051383)3.38236361
49centriole assembly (GO:0098534)3.37695202
50rRNA transcription (GO:0009303)3.37046914
51nuclear pore organization (GO:0006999)3.35224154
52nucleotide transmembrane transport (GO:1901679)3.30901843
53fatty acid elongation (GO:0030497)3.30451986
54centriole replication (GO:0007099)3.28518810
55intracellular estrogen receptor signaling pathway (GO:0030520)3.26456940
56kinetochore assembly (GO:0051382)3.25286715
57nucleotide-excision repair, DNA gap filling (GO:0006297)3.23085704
58pore complex assembly (GO:0046931)3.20559967
59sister chromatid segregation (GO:0000819)3.19067107
60positive regulation by host of viral transcription (GO:0043923)3.18553970
61GDP-mannose metabolic process (GO:0019673)3.17841703
62negative regulation of mRNA processing (GO:0050686)3.17191231
63telomere maintenance via telomere lengthening (GO:0010833)3.14168688
64GPI anchor biosynthetic process (GO:0006506)3.12306816
65mitotic nuclear envelope disassembly (GO:0007077)3.11732390
66DNA conformation change (GO:0071103)3.10855742
67meiotic chromosome segregation (GO:0045132)3.10548675
68negative regulation of mRNA metabolic process (GO:1903312)3.09090077
693-UTR-mediated mRNA stabilization (GO:0070935)3.06949419
70activation of Rac GTPase activity (GO:0032863)3.04267371
71chromosome condensation (GO:0030261)3.02486964
72positive regulation of developmental pigmentation (GO:0048087)3.01528866
73GPI anchor metabolic process (GO:0006505)3.00179682
74positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.97104918
75DNA topological change (GO:0006265)2.95955721
76regulation of double-strand break repair via homologous recombination (GO:0010569)2.95480335
77snRNA processing (GO:0016180)2.93942094
78negative regulation of erythrocyte differentiation (GO:0045647)2.92936528
79DNA replication-independent nucleosome organization (GO:0034724)2.92790483
80DNA replication-independent nucleosome assembly (GO:0006336)2.92790483
81DNA integration (GO:0015074)2.91831369
82mannosylation (GO:0097502)2.91588006
83tRNA methylation (GO:0030488)2.88028217
84regulation of translational termination (GO:0006449)2.86848130
85mitotic G1 DNA damage checkpoint (GO:0031571)2.84731189
86DNA ligation (GO:0006266)2.84638747
87nuclear envelope disassembly (GO:0051081)2.84266146
88membrane disassembly (GO:0030397)2.84266146
89negative regulation of DNA-templated transcription, elongation (GO:0032785)2.80628536
90ribosome biogenesis (GO:0042254)2.80597906
91aminoglycoside antibiotic metabolic process (GO:0030647)2.80555897
92negative regulation of RNA splicing (GO:0033119)2.80112253
93dosage compensation (GO:0007549)2.78822502
94microtubule polymerization or depolymerization (GO:0031109)2.77087658
95regulation of nuclear cell cycle DNA replication (GO:0033262)2.76714998
96telomere organization (GO:0032200)2.76373202
97regulation of RNA export from nucleus (GO:0046831)2.76119405
98DNA synthesis involved in DNA repair (GO:0000731)2.74909280
99myelination (GO:0042552)2.74564669
100folic acid-containing compound biosynthetic process (GO:0009396)2.74536713
101RNA stabilization (GO:0043489)2.74358135
102mRNA stabilization (GO:0048255)2.74358135
103histone exchange (GO:0043486)2.74317892
104negative regulation of histone methylation (GO:0031061)2.73087390
105ensheathment of neurons (GO:0007272)2.72927841
106axon ensheathment (GO:0008366)2.72927841
107chromatin assembly or disassembly (GO:0006333)2.72158953
108deoxyribonucleotide biosynthetic process (GO:0009263)2.68884236
109energy homeostasis (GO:0097009)2.68376895
110proline metabolic process (GO:0006560)2.67972204
111telomere maintenance (GO:0000723)2.67337890
112histone H2A acetylation (GO:0043968)2.66087415
113positive regulation of chromosome segregation (GO:0051984)2.65767156
114positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.65198824
115mitotic G1/S transition checkpoint (GO:0044819)2.65187087
116regulation of histone H3-K27 methylation (GO:0061085)2.64635688
117regulation of pigment cell differentiation (GO:0050932)2.64495614
118formation of translation preinitiation complex (GO:0001731)2.63284994
119ncRNA 3-end processing (GO:0043628)2.63083329
120developmental pigmentation (GO:0048066)2.63000562
121mitotic metaphase plate congression (GO:0007080)2.62762139
122collecting duct development (GO:0072044)2.61923819
123mannose metabolic process (GO:0006013)2.61626266
124histone H3-K4 trimethylation (GO:0080182)2.61547047
125L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.60107579
126nuclear envelope organization (GO:0006998)2.58852328
127ribonucleoprotein complex biogenesis (GO:0022613)2.55900738
128base-excision repair (GO:0006284)2.54643078
129peptidyl-lysine dimethylation (GO:0018027)2.54266581
130replicative senescence (GO:0090399)2.53474942
131DNA packaging (GO:0006323)2.53149503
132mesenchymal cell differentiation involved in renal system development (GO:2001012)2.52935200
133mesenchymal cell differentiation involved in kidney development (GO:0072161)2.52935200
134histone H3-K9 modification (GO:0061647)2.52835300
135C-terminal protein lipidation (GO:0006501)2.52672409
136regulation of somitogenesis (GO:0014807)2.52400383
137negative regulation of histone acetylation (GO:0035067)2.52151887
138positive regulation of uterine smooth muscle contraction (GO:0070474)2.51179158
139somatic diversification of immune receptors via somatic mutation (GO:0002566)2.50622306
140somatic hypermutation of immunoglobulin genes (GO:0016446)2.50622306
141positive regulation of DNA-dependent DNA replication (GO:2000105)2.50468880
142thymic T cell selection (GO:0045061)2.50218739
143positive regulation of histone deacetylation (GO:0031065)2.49621350
144metaphase plate congression (GO:0051310)2.49616820
145protein export from nucleus (GO:0006611)2.48081283
146transcription-coupled nucleotide-excision repair (GO:0006283)2.47070515
147DNA replication-dependent nucleosome organization (GO:0034723)2.46338132
148DNA replication-dependent nucleosome assembly (GO:0006335)2.46338132
149G1 DNA damage checkpoint (GO:0044783)2.45855351
150regulation of exit from mitosis (GO:0007096)2.45489381
151pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.45185633
152IMP biosynthetic process (GO:0006188)2.44837327
153positive regulation of cell fate commitment (GO:0010455)2.44671384
154protein complex localization (GO:0031503)2.44526235
155pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.44042460
156DNA strand renaturation (GO:0000733)2.43930492
157nuclear envelope reassembly (GO:0031468)2.43719472
158sulfate transport (GO:0008272)2.43092215
159DNA deamination (GO:0045006)2.43070607
160centrosome duplication (GO:0051298)2.42914137
161negative regulation of neurotransmitter secretion (GO:0046929)2.42701773
162proteasome assembly (GO:0043248)2.41420438
163DNA catabolic process, exonucleolytic (GO:0000738)2.39540971
164intra-S DNA damage checkpoint (GO:0031573)2.39407034
165maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.38526892
166regulation of DNA damage checkpoint (GO:2000001)2.37555885
167negative regulation of DNA-dependent DNA replication (GO:2000104)2.35290584
168protein localization to kinetochore (GO:0034501)2.32927036
169DNA methylation involved in gamete generation (GO:0043046)2.30423824
170establishment of chromosome localization (GO:0051303)2.29153102
171ear development (GO:0043583)2.28713261
172positive regulation of action potential (GO:0045760)2.27818726
173signal peptide processing (GO:0006465)2.26833862
174mesonephros development (GO:0001823)2.26732242
175mitotic sister chromatid cohesion (GO:0007064)2.25615118
176transcription elongation from RNA polymerase III promoter (GO:0006385)2.24352499
177termination of RNA polymerase III transcription (GO:0006386)2.24352499
178DNA demethylation (GO:0080111)2.24278647
179attachment of spindle microtubules to kinetochore (GO:0008608)2.21680700
180replication fork processing (GO:0031297)2.21444749
181detection of molecule of bacterial origin (GO:0032490)2.21383453
182regulation of non-canonical Wnt signaling pathway (GO:2000050)2.21185343
183negative regulation of transcription by competitive promoter binding (GO:0010944)2.20948389
184regulation of DNA endoreduplication (GO:0032875)2.20846015
185IMP metabolic process (GO:0046040)2.20640134

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.23726717
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.54594257
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.53652516
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.44649211
5MYC_22102868_ChIP-Seq_BL_Human3.29231012
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.15951806
7VDR_21846776_ChIP-Seq_THP-1_Human2.96072312
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.85483915
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.83941111
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.81351947
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.78912214
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.73416728
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.44512822
14* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.32444490
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.19973599
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.18128695
17* LXR_22292898_ChIP-Seq_THP-1_Human2.15398620
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.07219275
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06830347
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.02755035
21DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.94340641
22GABP_17652178_ChIP-ChIP_JURKAT_Human1.94005750
23SRF_21415370_ChIP-Seq_HL-1_Mouse1.93253803
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.91450778
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90407737
26XRN2_22483619_ChIP-Seq_HELA_Human1.89993485
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.80713462
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79374910
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.78229717
30POU5F1_16153702_ChIP-ChIP_HESCs_Human1.77284359
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.76157645
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74415556
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.72017706
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.70799537
35* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.70784290
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.70724348
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.70541168
38* RACK7_27058665_Chip-Seq_MCF-7_Human1.69313122
39P68_20966046_ChIP-Seq_HELA_Human1.69092825
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66113528
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65955400
42TCF7_22412390_ChIP-Seq_EML_Mouse1.65386007
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64999361
44MYC_18555785_ChIP-Seq_MESCs_Mouse1.64279538
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.64213251
46DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.63961939
47KDM2B_26808549_Chip-Seq_DND41_Human1.60989081
48SCL_19346495_ChIP-Seq_HPC-7_Human1.59390940
49VDR_23849224_ChIP-Seq_CD4+_Human1.58592412
50LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57590535
51EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55802278
52IRF1_19129219_ChIP-ChIP_H3396_Human1.55456723
53FOXP3_21729870_ChIP-Seq_TREG_Human1.55393383
54CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.55149199
55TET1_21451524_ChIP-Seq_MESCs_Mouse1.54958690
56GBX2_23144817_ChIP-Seq_PC3_Human1.53812823
57EWS_26573619_Chip-Seq_HEK293_Human1.52846840
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52183330
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51964465
60MAF_26560356_Chip-Seq_TH1_Human1.48182780
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.47888292
62MAF_26560356_Chip-Seq_TH2_Human1.46568514
63KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46015294
64KDM5A_27292631_Chip-Seq_BREAST_Human1.45054237
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44862529
66* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.44322589
67KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43654225
68MYC_18358816_ChIP-ChIP_MESCs_Mouse1.42370525
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40593973
70THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40183270
71EGR1_19374776_ChIP-ChIP_THP-1_Human1.40025671
72IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.39575310
73ELK1_19687146_ChIP-ChIP_HELA_Human1.39390138
74AR_21909140_ChIP-Seq_LNCAP_Human1.39020765
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37106600
76* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.37015872
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36243442
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36026652
79YY1_21170310_ChIP-Seq_MESCs_Mouse1.35178661
80ETS1_20019798_ChIP-Seq_JURKAT_Human1.35046930
81UTX_26944678_Chip-Seq_JUKART_Human1.33870921
82FUS_26573619_Chip-Seq_HEK293_Human1.33375522
83SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32636339
84SA1_27219007_Chip-Seq_ERYTHROID_Human1.32377465
85ELF1_20517297_ChIP-Seq_JURKAT_Human1.32251967
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.31987202
87IRF8_21731497_ChIP-ChIP_J774_Mouse1.31306394
88VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30694409
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30202925
90GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29572342
91SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.27000093
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26585024
93CTCF_27219007_Chip-Seq_ERYTHROID_Human1.25294952
94FLI1_27457419_Chip-Seq_LIVER_Mouse1.24906509
95ZNF263_19887448_ChIP-Seq_K562_Human1.24607722
96* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24147624
97* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23236214
98PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22941362
99VDR_24763502_ChIP-Seq_THP-1_Human1.22692336
100NCOR1_26117541_ChIP-Seq_K562_Human1.22041789
101SUZ12_18555785_Chip-Seq_ESCs_Mouse1.21852292
102RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21682298
103CIITA_25753668_ChIP-Seq_RAJI_Human1.21218477
104* SMC4_20622854_ChIP-Seq_HELA_Human1.20334972
105ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20138048
106STAT3_18555785_Chip-Seq_ESCs_Mouse1.19772816
107DCP1A_22483619_ChIP-Seq_HELA_Human1.19686847
108TP63_17297297_ChIP-ChIP_HaCaT_Human1.17993366
109KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17321891
110SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16892150
111FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16113003
112ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16032756
113EZH2_27294783_Chip-Seq_NPCs_Mouse1.15728238
114NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15665692
115ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13986460
116STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13947856
117* BCL6_27268052_Chip-Seq_Bcells_Human1.13918456
118NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13613855
119CREB1_26743006_Chip-Seq_LNCaP_Human1.13038508
120LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12678598
121MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.12675426
122CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12070261
123TTF2_22483619_ChIP-Seq_HELA_Human1.11983596
124SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11938183
125POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11866636
126* PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.11474529
127* BCOR_27268052_Chip-Seq_Bcells_Human1.10102861
128PHF8_20622854_ChIP-Seq_HELA_Human1.09940722
129RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09637130
130IGF1R_20145208_ChIP-Seq_DFB_Human1.09397446
131FOXP1_21924763_ChIP-Seq_HESCs_Human1.09363769
132KDM2B_26808549_Chip-Seq_JURKAT_Human1.07887005
133KDM2B_26808549_Chip-Seq_K562_Human1.07548386
134RUNX1_22412390_ChIP-Seq_EML_Mouse1.07222591
135GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07048912
136* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06965332
137TP53_22127205_ChIP-Seq_IMR90_Human1.06078852
138CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05514975
139CTCF_26484167_Chip-Seq_Bcells_Mouse1.04918149
140GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04839806
141PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04551640
142NOTCH1_21737748_ChIP-Seq_TLL_Human1.04516037
143P300_18555785_Chip-Seq_ESCs_Mouse1.04461336
144PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04442780
145CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04300601
146SOX2_16153702_ChIP-ChIP_HESCs_Human1.03037087
147MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02939669
148RARA_24833708_ChIP-Seq_LIVER_Mouse1.02626442
149BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02434080
150SPI1_23547873_ChIP-Seq_NB4_Human1.01558333
151RUNX1_27457419_Chip-Seq_LIVER_Mouse1.01322639
152MYCN_18555785_ChIP-Seq_MESCs_Mouse1.00398732
153NANOG_18555785_Chip-Seq_ESCs_Mouse0.99538167
154TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98496515
155E2F1_18555785_Chip-Seq_ESCs_Mouse0.98159817
156MYC_18940864_ChIP-ChIP_HL60_Human0.97423567
157OCT4_18555785_Chip-Seq_ESCs_Mouse0.96422023
158GABP_19822575_ChIP-Seq_HepG2_Human0.95802575
159TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95355597
160P53_22387025_ChIP-Seq_ESCs_Mouse0.95137233
161CMYC_18555785_Chip-Seq_ESCs_Mouse0.94451536
162NMYC_18555785_Chip-Seq_ESCs_Mouse0.93987825
163EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93425154
164KLF4_18555785_Chip-Seq_ESCs_Mouse0.93381086
165ZFX_18555785_Chip-Seq_ESCs_Mouse0.93003277
166* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92946510
167ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92915333
168FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.92673871
169* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.91278159
170* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.90708583
171SOX2_18555785_Chip-Seq_ESCs_Mouse0.89514266
172PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87844688
173PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87635321

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis5.13549027
2MP0008057_abnormal_DNA_replication3.69746925
3MP0010094_abnormal_chromosome_stability3.27696203
4MP0004185_abnormal_adipocyte_glucose3.18101904
5MP0006292_abnormal_olfactory_placode3.07919583
6MP0002396_abnormal_hematopoietic_system3.00372947
7MP0003705_abnormal_hypodermis_morpholog2.97239445
8MP0005076_abnormal_cell_differentiation2.61858380
9MP0003111_abnormal_nucleus_morphology2.58411640
10MP0008058_abnormal_DNA_repair2.56769740
11MP0003693_abnormal_embryo_hatching2.53991114
12MP0009278_abnormal_bone_marrow2.41470228
13MP0008260_abnormal_autophagy2.38433711
14MP0009697_abnormal_copulation2.32456320
15MP0002938_white_spotting2.20904840
16MP0001346_abnormal_lacrimal_gland2.20600719
17MP0005171_absent_coat_pigmentation2.14341828
18MP0003077_abnormal_cell_cycle2.08838730
19MP0005645_abnormal_hypothalamus_physiol2.08458123
20MP0002877_abnormal_melanocyte_morpholog2.06454258
21MP0005409_darkened_coat_color2.02841724
22MP0000678_abnormal_parathyroid_gland2.00634247
23MP0001730_embryonic_growth_arrest1.97166016
24MP0001529_abnormal_vocalization1.95041765
25MP0001873_stomach_inflammation1.90542033
26MP0002277_abnormal_respiratory_mucosa1.87465498
27MP0000920_abnormal_myelination1.86425255
28MP0005075_abnormal_melanosome_morpholog1.77654534
29MP0001849_ear_inflammation1.74337087
30MP0008877_abnormal_DNA_methylation1.74090732
31MP0001348_abnormal_lacrimal_gland1.69052432
32MP0003950_abnormal_plasma_membrane1.65174359
33MP0000537_abnormal_urethra_morphology1.61112734
34MP0008932_abnormal_embryonic_tissue1.60090999
35MP0010307_abnormal_tumor_latency1.57780457
36MP0005646_abnormal_pituitary_gland1.57308654
37MP0004957_abnormal_blastocyst_morpholog1.57289359
38MP0010030_abnormal_orbit_morphology1.57036664
39MP0001293_anophthalmia1.56242244
40MP0005501_abnormal_skin_physiology1.55096293
41MP0004858_abnormal_nervous_system1.53203698
42MP0002163_abnormal_gland_morphology1.52784584
43MP0000383_abnormal_hair_follicle1.52747160
44MP0000015_abnormal_ear_pigmentation1.52660662
45MP0005380_embryogenesis_phenotype1.47536137
46MP0001672_abnormal_embryogenesis/_devel1.47536137
47MP0003136_yellow_coat_color1.45698048
48MP0004381_abnormal_hair_follicle1.45317082
49MP0005666_abnormal_adipose_tissue1.43826540
50MP0001485_abnormal_pinna_reflex1.43761419
51MP0002080_prenatal_lethality1.42170104
52MP0003984_embryonic_growth_retardation1.40371293
53MP0002019_abnormal_tumor_incidence1.37192814
54MP0003937_abnormal_limbs/digits/tail_de1.36608368
55MP0000003_abnormal_adipose_tissue1.36267827
56MP0004808_abnormal_hematopoietic_stem1.35541971
57MP0002166_altered_tumor_susceptibility1.33079036
58MP0003436_decreased_susceptibility_to1.32734093
59MP0005058_abnormal_lysosome_morphology1.32672952
60MP0002095_abnormal_skin_pigmentation1.31387993
61MP0002088_abnormal_embryonic_growth/wei1.29491646
62MP0001986_abnormal_taste_sensitivity1.29074815
63MP0003121_genomic_imprinting1.28530542
64MP0008007_abnormal_cellular_replicative1.27491758
65MP0001661_extended_life_span1.25115226
66MP0000685_abnormal_immune_system1.24502508
67MP0004742_abnormal_vestibular_system1.23612934
68MP0005257_abnormal_intraocular_pressure1.22749160
69MP0001188_hyperpigmentation1.21585248
70MP0010234_abnormal_vibrissa_follicle1.21182501
71MP0001697_abnormal_embryo_size1.19058716
72MP0000490_abnormal_crypts_of1.17713416
73MP0009672_abnormal_birth_weight1.17595955
74MP0002009_preneoplasia1.16810516
75MP0005375_adipose_tissue_phenotype1.16511058
76MP0002722_abnormal_immune_system1.16300606
77MP0005083_abnormal_biliary_tract1.15487506
78MP0003878_abnormal_ear_physiology1.15000053
79MP0005377_hearing/vestibular/ear_phenot1.15000053
80MP0002085_abnormal_embryonic_tissue1.13184325
81MP0003941_abnormal_skin_development1.12533515
82MP0003172_abnormal_lysosome_physiology1.11629343
83MP0000733_abnormal_muscle_development1.11613186
84MP0002796_impaired_skin_barrier1.10928743
85MP0002429_abnormal_blood_cell1.10077363
86MP0000613_abnormal_salivary_gland1.09336836
87MP0003938_abnormal_ear_development1.08115228
88MP0003453_abnormal_keratinocyte_physiol1.06415952
89MP0000858_altered_metastatic_potential1.04357123
90MP0005310_abnormal_salivary_gland1.02461117
91MP0002086_abnormal_extraembryonic_tissu1.01758289
92MP0000358_abnormal_cell_content/1.00926815
93MP0005671_abnormal_response_to1.00918470
94MP0003122_maternal_imprinting0.98572386
95MP0003763_abnormal_thymus_physiology0.97343139
96MP0005621_abnormal_cell_physiology0.95562202
97MP0009931_abnormal_skin_appearance0.94552677
98MP0003315_abnormal_perineum_morphology0.94514689
99MP0000689_abnormal_spleen_morphology0.93640550
100MP0002075_abnormal_coat/hair_pigmentati0.93162168
101MP0000462_abnormal_digestive_system0.92544452
102MP0002210_abnormal_sex_determination0.92408213
103MP0004197_abnormal_fetal_growth/weight/0.92030789
104MP0000049_abnormal_middle_ear0.90769802
105MP0004233_abnormal_muscle_weight0.90016873
106MP0002132_abnormal_respiratory_system0.89806934
107MP0004134_abnormal_chest_morphology0.88419588
108MP0001186_pigmentation_phenotype0.87108522
109MP0000470_abnormal_stomach_morphology0.86840111
110MP0004947_skin_inflammation0.86409618
111MP0003890_abnormal_embryonic-extraembry0.86247602
112MP0005451_abnormal_body_composition0.86110793
113MP0005384_cellular_phenotype0.85648307
114MP0005174_abnormal_tail_pigmentation0.85634995
115MP0006035_abnormal_mitochondrial_morpho0.84652338
116MP0000579_abnormal_nail_morphology0.84338466
117MP0002970_abnormal_white_adipose0.84334354
118MP0002084_abnormal_developmental_patter0.84278940
119MP0005379_endocrine/exocrine_gland_phen0.84186181
120MP0003786_premature_aging0.84066985
121MP0005408_hypopigmentation0.83265193
122MP0008789_abnormal_olfactory_epithelium0.82877161
123MP0000631_abnormal_neuroendocrine_gland0.82564774
124MP0002177_abnormal_outer_ear0.81832510
125MP0001800_abnormal_humoral_immune0.81508697
126MP0002006_tumorigenesis0.81501469
127MP0000477_abnormal_intestine_morphology0.81310679
128MP0001545_abnormal_hematopoietic_system0.81246764
129MP0005397_hematopoietic_system_phenotyp0.81246764
130MP0002249_abnormal_larynx_morphology0.78062365
131MP0000313_abnormal_cell_death0.77437753
132MP0000703_abnormal_thymus_morphology0.77161815
133MP0004264_abnormal_extraembryonic_tissu0.76257177
134MP0009250_abnormal_appendicular_skeleto0.76189744
135MP0002254_reproductive_system_inflammat0.75906233
136MP0002398_abnormal_bone_marrow0.74943923
137MP0010352_gastrointestinal_tract_polyps0.74114549
138MP0002098_abnormal_vibrissa_morphology0.73339223
139MP0003787_abnormal_imprinting0.73041039
140MP0002233_abnormal_nose_morphology0.72801380
141MP0003123_paternal_imprinting0.71376458
142MP0004147_increased_porphyrin_level0.71296122
143MP0002102_abnormal_ear_morphology0.69720443
144MP0004142_abnormal_muscle_tone0.69574521
145MP0004043_abnormal_pH_regulation0.69498965
146MP0009333_abnormal_splenocyte_physiolog0.69313247
147MP0002092_abnormal_eye_morphology0.68161418
148MP0001486_abnormal_startle_reflex0.68031344
149MP0000350_abnormal_cell_proliferation0.67917221
150MP0001216_abnormal_epidermal_layer0.67268169
151MP0000372_irregular_coat_pigmentation0.67206860
152MP0003115_abnormal_respiratory_system0.67115405
153MP0003566_abnormal_cell_adhesion0.65915336
154MP0002111_abnormal_tail_morphology0.65765319
155MP0003943_abnormal_hepatobiliary_system0.65674099
156MP0001145_abnormal_male_reproductive0.65266753
157MP0003303_peritoneal_inflammation0.64465214
158MP0000653_abnormal_sex_gland0.64054533
159MP0000762_abnormal_tongue_morphology0.63115784
160MP0002148_abnormal_hypersensitivity_rea0.62414880
161MP0000716_abnormal_immune_system0.62369508
162MP0002723_abnormal_immune_serum0.62324755
163MP0003183_abnormal_peptide_metabolism0.61967849
164MP0002420_abnormal_adaptive_immunity0.60416423
165MP0003718_maternal_effect0.60173183
166MP0002109_abnormal_limb_morphology0.59990551
167MP0001819_abnormal_immune_cell0.59626235
168MP0000681_abnormal_thyroid_gland0.59493760

Predicted human phenotypes

RankGene SetZ-score
1Broad distal phalanx of finger (HP:0009836)4.45326380
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.37303544
3Parakeratosis (HP:0001036)4.30879207
4Chromsome breakage (HP:0040012)4.18826247
5Birth length less than 3rd percentile (HP:0003561)3.88737793
6Duplicated collecting system (HP:0000081)3.73582090
7Abnormality of the renal collecting system (HP:0004742)3.73313680
8Ectopic kidney (HP:0000086)3.60783930
9Hyperacusis (HP:0010780)3.54364672
10Patchy hypopigmentation of hair (HP:0011365)3.44654830
11White forelock (HP:0002211)3.31751861
12Cerebral hypomyelination (HP:0006808)3.27052170
13Prostate neoplasm (HP:0100787)3.18844848
14Septo-optic dysplasia (HP:0100842)3.10039465
15Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.91389550
16Abnormality of the thoracic spine (HP:0100711)2.81240645
17Absent septum pellucidum (HP:0001331)2.80152786
1811 pairs of ribs (HP:0000878)2.77913635
19Abnormality of the fingertips (HP:0001211)2.76407105
20Selective tooth agenesis (HP:0001592)2.74574970
21Premature graying of hair (HP:0002216)2.74281384
22Deep palmar crease (HP:0006191)2.69134993
23Thoracic kyphosis (HP:0002942)2.68360347
24Squamous cell carcinoma (HP:0002860)2.68081305
25Congenital sensorineural hearing impairment (HP:0008527)2.67809253
26Abnormality of the preputium (HP:0100587)2.66933784
27High anterior hairline (HP:0009890)2.66341112
28Progressive muscle weakness (HP:0003323)2.58442681
29Aplasia/Hypoplasia of the uvula (HP:0010293)2.57013055
30Supernumerary nipples (HP:0002558)2.53108668
31Ulnar bowing (HP:0003031)2.51421637
32Abnormality of the ileum (HP:0001549)2.49893080
33Osteomalacia (HP:0002749)2.49329086
34Unilateral renal agenesis (HP:0000122)2.48769370
35Meckel diverticulum (HP:0002245)2.48418195
36Lip pit (HP:0100267)2.47990618
37Abnormality of the septum pellucidum (HP:0007375)2.47912168
38Abnormality of chromosome stability (HP:0003220)2.46656319
39Long palpebral fissure (HP:0000637)2.44299567
40Degeneration of the lateral corticospinal tracts (HP:0002314)2.41458797
41Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.41458797
42Reticulocytopenia (HP:0001896)2.39185149
43Bone marrow hypocellularity (HP:0005528)2.36428917
44High pitched voice (HP:0001620)2.35223545
45Stomach cancer (HP:0012126)2.35085203
46Ectropion (HP:0000656)2.34274221
47Cheilitis (HP:0100825)2.33190429
48Colitis (HP:0002583)2.31544930
49Abnormality of cells of the erythroid lineage (HP:0012130)2.30768066
50Truncus arteriosus (HP:0001660)2.27527838
51Anomalous pulmonary venous return (HP:0010772)2.26806607
52Long eyelashes (HP:0000527)2.24879099
53Recurrent pneumonia (HP:0006532)2.24746839
54Breast hypoplasia (HP:0003187)2.23371744
55Disproportionate tall stature (HP:0001519)2.21178505
56Broad face (HP:0000283)2.21120210
57Duplication of thumb phalanx (HP:0009942)2.19468225
58Self-mutilation (HP:0000742)2.19208650
59Stridor (HP:0010307)2.17157180
60Abnormality of the prostate (HP:0008775)2.16086172
61Morphological abnormality of the inner ear (HP:0011390)2.15342341
62Abnormal number of erythroid precursors (HP:0012131)2.14212945
63Abnormality of the parietal bone (HP:0002696)2.13010580
64Ureteral duplication (HP:0000073)2.11786834
65Abnormal number of incisors (HP:0011064)2.11675807
66Abnormal trabecular bone morphology (HP:0100671)2.11122363
67Hypoplasia of the capital femoral epiphysis (HP:0003090)2.10837158
68Slow saccadic eye movements (HP:0000514)2.09149922
69Abnormality of reticulocytes (HP:0004312)2.08738146
70Decreased lacrimation (HP:0000633)2.08705869
71Proximal placement of thumb (HP:0009623)2.06785164
72Deviation of the thumb (HP:0009603)2.06198544
73Cupped ear (HP:0000378)2.05741343
74Abnormality of the columella (HP:0009929)2.05419930
75Chronic otitis media (HP:0000389)2.05356913
76Cellulitis (HP:0100658)2.04997765
77Septate vagina (HP:0001153)2.04434025
78Annular pancreas (HP:0001734)2.04394100
79Alacrima (HP:0000522)2.03582878
80Abnormal hair whorl (HP:0010721)2.02357349
81Abnormality of incisor morphology (HP:0011063)2.01957632
82Atresia of the external auditory canal (HP:0000413)2.00236576
83Dislocated radial head (HP:0003083)2.00034573
84Cafe-au-lait spot (HP:0000957)1.99719921
85Testicular atrophy (HP:0000029)1.97462351
86Abnormality of the radial head (HP:0003995)1.97085964
87Type I transferrin isoform profile (HP:0003642)1.96838964
88Poikiloderma (HP:0001029)1.96441918
89Clubbing of toes (HP:0100760)1.95172439
90Rectal prolapse (HP:0002035)1.95014673
91Gastrointestinal inflammation (HP:0004386)1.94689288
92Reticulocytosis (HP:0001923)1.94315881
93Duodenal stenosis (HP:0100867)1.93806129
94Small intestinal stenosis (HP:0012848)1.93806129
95Myelomeningocele (HP:0002475)1.92097276
96Microvesicular hepatic steatosis (HP:0001414)1.91950756
97Insomnia (HP:0100785)1.91744367
98J-shaped sella turcica (HP:0002680)1.91433169
99Sloping forehead (HP:0000340)1.91096161
100Prolonged neonatal jaundice (HP:0006579)1.91036576
101Spina bifida occulta (HP:0003298)1.89676120
102Abnormal lung lobation (HP:0002101)1.89269854
103Aplasia/Hypoplasia of the fovea (HP:0008060)1.88849431
104Hypoplasia of the fovea (HP:0007750)1.88849431
105Ragged-red muscle fibers (HP:0003200)1.88777127
106Intestinal atresia (HP:0011100)1.87551824
107Flared metaphyses (HP:0003015)1.87370329
108Pointed chin (HP:0000307)1.87261524
109Thin bony cortex (HP:0002753)1.86651324
110Distal lower limb amyotrophy (HP:0008944)1.86612743
111Abnormality of cochlea (HP:0000375)1.86340044
112Anteriorly placed anus (HP:0001545)1.85866004
113Patellar aplasia (HP:0006443)1.85641360
114Clitoromegaly (HP:0000057)1.83853387
115Acute lymphatic leukemia (HP:0006721)1.83659684
116Microtia (HP:0008551)1.83212974
117Abnormality of the carotid arteries (HP:0005344)1.82834904
118Adrenal hypoplasia (HP:0000835)1.82196350
119Microretrognathia (HP:0000308)1.81993536
120Abnormality of the labia minora (HP:0012880)1.81626064
121Erythroderma (HP:0001019)1.81625466
122Agammaglobulinemia (HP:0004432)1.81035315
123Impulsivity (HP:0100710)1.80622301
124Bowed forearm bones (HP:0003956)1.80416692
125Bowing of the arm (HP:0006488)1.80416692
126Abnormality of the pulmonary veins (HP:0011718)1.80376405
127Slender long bone (HP:0003100)1.79728401
128Renal agenesis (HP:0000104)1.79412759
129Prominent nose (HP:0000448)1.77444762
130Asymmetry of the thorax (HP:0001555)1.77392795
131Aplasia/Hypoplasia of the patella (HP:0006498)1.77251959
1323-Methylglutaconic aciduria (HP:0003535)1.77247885
133Nasolacrimal duct obstruction (HP:0000579)1.76247402
134Premature skin wrinkling (HP:0100678)1.75574004
135Abnormality of DNA repair (HP:0003254)1.75166989
136Absent thumb (HP:0009777)1.75018715
137Increased neuronal autofluorescent lipopigment (HP:0002074)1.74603553
138Split foot (HP:0001839)1.74451957
139Spinal cord compression (HP:0002176)1.74054631
140Progressive external ophthalmoplegia (HP:0000590)1.73426078
141Absent radius (HP:0003974)1.73305026
142Hypergonadotropic hypogonadism (HP:0000815)1.73053567
143Short nail (HP:0001799)1.72596577
144Seborrheic dermatitis (HP:0001051)1.72355407
145Biconcave vertebral bodies (HP:0004586)1.72203322
146Short thumb (HP:0009778)1.71095676
147Optic nerve hypoplasia (HP:0000609)1.70957514
148True hermaphroditism (HP:0010459)1.70705413
149Trismus (HP:0000211)1.70001381
150Hypoplastic labia majora (HP:0000059)1.69555509
151Hypertensive crisis (HP:0100735)1.69278817
152Broad phalanges of the hand (HP:0009768)1.69064374
153Abnormality of the distal phalanx of the thumb (HP:0009617)1.68729119
154Hemorrhage of the eye (HP:0011885)1.68098409
155Prominent occiput (HP:0000269)1.67998101
156Pulmonary artery stenosis (HP:0004415)1.67939665
157Optic nerve coloboma (HP:0000588)1.66956860
158Hepatosplenomegaly (HP:0001433)1.66751510
159Triphalangeal thumb (HP:0001199)1.66585429
160Medulloblastoma (HP:0002885)1.66369149
161Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.66238293
162Absent epiphyses (HP:0010577)1.66238293
163Metaphyseal cupping (HP:0003021)1.66191133
164Lymphoma (HP:0002665)1.66088707
165Absent eyebrow (HP:0002223)1.65752018
166Aplasia/Hypoplasia of the sacrum (HP:0008517)1.65068857
167Preauricular skin tag (HP:0000384)1.64990537
168Nephroblastoma (Wilms tumor) (HP:0002667)1.64558549
169Myelodysplasia (HP:0002863)1.63939411
170Patellar dislocation (HP:0002999)1.63552565
171Pancreatic islet-cell hyperplasia (HP:0004510)1.63338658
172Abnormality of the duodenum (HP:0002246)1.63072821
173Renal cell carcinoma (HP:0005584)1.62970176
174Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.62691149
175Dysmetric saccades (HP:0000641)1.62466822
176Myopathic facies (HP:0002058)1.61329249
177Renal dysplasia (HP:0000110)1.61209014
178Urethral obstruction (HP:0000796)1.59900991
179Small epiphyses (HP:0010585)1.59206837
180Abnormality of the incisor (HP:0000676)1.59088311
181Small hand (HP:0200055)1.58923249

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.56377388
2SMG14.47904446
3EEF2K3.18771927
4CDK83.09102981
5SIK33.07214760
6CDC73.04593225
7ICK2.65744942
8NME22.46510861
9MAP3K102.46501496
10VRK12.43115745
11CLK12.39560212
12INSRR2.22394532
13BUB12.20531850
14STK392.20177143
15ZAK2.11537296
16ERN12.06135866
17PLK42.02003073
18SRPK12.00418835
19PKN21.97895599
20MKNK11.87420747
21TNIK1.75972151
22ATR1.73593653
23TTK1.73521194
24IRAK41.73438323
25BRD41.68047702
26OXSR11.67499137
27VRK21.64570206
28TXK1.64236533
29MAP2K31.51636828
30CDK71.48679182
31EIF2AK21.48381077
32PRPF4B1.48332465
33MAPKAPK51.46984947
34PASK1.43837243
35CDK121.43482486
36NEK61.40713402
37CDK41.38337072
38KDR1.33425127
39STK41.30139115
40PKN11.26517465
41MAP3K111.26371477
42PBK1.26212210
43PTK61.23308888
44CHEK21.21933425
45YES11.21186415
46BMPR1B1.19664614
47MST1R1.16742830
48SIK21.16255706
49TAOK31.14805066
50MARK31.11576188
51MAP3K141.10708560
52TEC1.10583121
53NEK21.10311047
54RPS6KA51.07457238
55MTOR1.06921289
56TAF11.06906447
57BRSK11.06858071
58MAP2K21.05780253
59CDK31.05323516
60PLK11.03024009
61MAP3K81.03021664
62EPHA21.02203514
63WNK11.01358263
64TLK11.01092221
65EIF2AK30.99419608
66BLK0.98848990
67MKNK20.97600089
68BCR0.95795166
69RPS6KB20.95033861
70TSSK60.94652649
71SIK10.94299888
72FGFR40.94001101
73STK160.93556516
74WEE10.92252308
75RPS6KA40.90531129
76PRKD30.89244907
77TESK20.87574319
78CHEK10.87489774
79RPS6KC10.86146983
80RPS6KL10.86146983
81ADRBK20.85102373
82BRSK20.84620416
83NME10.82191479
84PLK30.81975010
85PAK40.81772311
86RPS6KA20.81692527
87IRAK20.80744893
88ATM0.80083358
89TTN0.79860561
90MAP3K130.79852446
91BTK0.76802566
92BMX0.76699102
93GRK60.76258947
94PRKCI0.75740261
95MAPK150.75066090
96CCNB10.74628994
97CSNK1A1L0.74400282
98MET0.73621422
99AURKB0.72827002
100JAK30.72251623
101CAMK1D0.71826803
102RPS6KA60.71286976
103IKBKB0.70703219
104CDK190.70382525
105ITK0.70350135
106NUAK10.70045844
107BRAF0.69861325
108MAP4K10.68888511
109LRRK20.66970530
110CASK0.66907237
111TAOK10.66294974
112STK100.65549489
113SCYL20.63929000
114HIPK20.63142784
115MARK20.58573804
116CDK10.58444822
117CDC42BPA0.58429589
118EPHB10.58411084
119TNK20.57878748
120ILK0.56040795
121LYN0.56025887
122TAOK20.56003793
123CDK20.55871707
124AKT30.55736018
125UHMK10.55543938
126CAMK1G0.54502325
127KIT0.53655115
128RPS6KA10.53078244
129PRKD20.52984947
130CSF1R0.52904362
131MELK0.51373810
132CDK90.50486853
133EIF2AK10.48278704
134MAPK110.47082876
135STK30.46953362
136CSNK2A10.46657116
137AKT20.45547063
138ARAF0.45395690
139CSNK1D0.44801699
140PDPK10.44309355
141CSNK1G30.43857498
142LATS10.41604294
143MAPK140.41063572
144EPHA30.41015595
145AURKA0.40951276
146IRAK30.40294382
147RIPK40.39617598
148DAPK10.39095739
149MAP3K70.38943595
150TYK20.38621735
151PIM20.37871644
152MAPKAPK20.37173114
153MAP2K60.34533004
154CAMKK10.33310465
155AKT10.32124098
156PRKAA10.31973083
157MAP3K30.30743072

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.44420668
2Mismatch repair_Homo sapiens_hsa034304.01382547
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.13407850
4* Homologous recombination_Homo sapiens_hsa034403.08062166
5Base excision repair_Homo sapiens_hsa034103.03927375
6Fanconi anemia pathway_Homo sapiens_hsa034602.96431285
7Non-homologous end-joining_Homo sapiens_hsa034502.93072494
8Sulfur relay system_Homo sapiens_hsa041222.84698530
9Basal transcription factors_Homo sapiens_hsa030222.58106044
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.54044630
11Nucleotide excision repair_Homo sapiens_hsa034202.37046964
12RNA polymerase_Homo sapiens_hsa030202.32795711
13Cell cycle_Homo sapiens_hsa041102.25456127
14Spliceosome_Homo sapiens_hsa030402.11951104
15Bladder cancer_Homo sapiens_hsa052192.11659816
16Protein export_Homo sapiens_hsa030602.11492534
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.07681518
18Non-small cell lung cancer_Homo sapiens_hsa052232.03011753
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.98911258
20Chronic myeloid leukemia_Homo sapiens_hsa052201.98617884
21Acute myeloid leukemia_Homo sapiens_hsa052211.85188406
22RNA degradation_Homo sapiens_hsa030181.76479090
23Fatty acid elongation_Homo sapiens_hsa000621.75610240
24One carbon pool by folate_Homo sapiens_hsa006701.75148857
25Pyrimidine metabolism_Homo sapiens_hsa002401.74571848
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.71774311
27Proteasome_Homo sapiens_hsa030501.62936377
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.61563721
29Steroid biosynthesis_Homo sapiens_hsa001001.57100049
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.49576617
31Central carbon metabolism in cancer_Homo sapiens_hsa052301.49102842
32Ether lipid metabolism_Homo sapiens_hsa005651.47880821
33Biosynthesis of amino acids_Homo sapiens_hsa012301.43663613
34Fructose and mannose metabolism_Homo sapiens_hsa000511.42249379
35VEGF signaling pathway_Homo sapiens_hsa043701.35740057
36Primary immunodeficiency_Homo sapiens_hsa053401.34644700
37Pentose phosphate pathway_Homo sapiens_hsa000301.30577791
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.27296814
39RNA transport_Homo sapiens_hsa030131.25636816
40Purine metabolism_Homo sapiens_hsa002301.21489171
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.20308057
42Thyroid cancer_Homo sapiens_hsa052161.19963336
43Linoleic acid metabolism_Homo sapiens_hsa005911.19860648
44Herpes simplex infection_Homo sapiens_hsa051681.16951318
45Sphingolipid metabolism_Homo sapiens_hsa006001.16433495
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.11524326
47mTOR signaling pathway_Homo sapiens_hsa041501.11372147
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08807958
49Arachidonic acid metabolism_Homo sapiens_hsa005901.08125301
50Endometrial cancer_Homo sapiens_hsa052131.04053986
51Longevity regulating pathway - mammal_Homo sapiens_hsa042111.03576262
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02655444
53Hematopoietic cell lineage_Homo sapiens_hsa046401.02438909
54Colorectal cancer_Homo sapiens_hsa052101.01570603
55Alcoholism_Homo sapiens_hsa050341.01353559
56Glioma_Homo sapiens_hsa052141.01114520
57Folate biosynthesis_Homo sapiens_hsa007900.99763504
58Vitamin B6 metabolism_Homo sapiens_hsa007500.96916383
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.96368171
60mRNA surveillance pathway_Homo sapiens_hsa030150.90793598
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90139653
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89328983
63p53 signaling pathway_Homo sapiens_hsa041150.87832509
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87582782
65Autoimmune thyroid disease_Homo sapiens_hsa053200.86296511
66Galactose metabolism_Homo sapiens_hsa000520.86185196
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84967097
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82884946
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80688413
70Notch signaling pathway_Homo sapiens_hsa043300.79916777
71AMPK signaling pathway_Homo sapiens_hsa041520.79146715
72Insulin signaling pathway_Homo sapiens_hsa049100.78319155
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.77557098
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76086054
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.73575009
76ErbB signaling pathway_Homo sapiens_hsa040120.71229610
77Renal cell carcinoma_Homo sapiens_hsa052110.70796531
78Measles_Homo sapiens_hsa051620.70337650
79N-Glycan biosynthesis_Homo sapiens_hsa005100.68028932
80Epstein-Barr virus infection_Homo sapiens_hsa051690.67541519
81Inositol phosphate metabolism_Homo sapiens_hsa005620.58834376
82Allograft rejection_Homo sapiens_hsa053300.58627917
83HTLV-I infection_Homo sapiens_hsa051660.57906268
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57858623
85Choline metabolism in cancer_Homo sapiens_hsa052310.57708149
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57451666
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.56292513
88Carbon metabolism_Homo sapiens_hsa012000.55042529
89Hepatitis C_Homo sapiens_hsa051600.54251368
90Regulation of autophagy_Homo sapiens_hsa041400.53978501
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53680697
92Systemic lupus erythematosus_Homo sapiens_hsa053220.52721372
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52311371
94Graft-versus-host disease_Homo sapiens_hsa053320.51486824
95Viral carcinogenesis_Homo sapiens_hsa052030.50228251
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49096570
97HIF-1 signaling pathway_Homo sapiens_hsa040660.47369411
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47309025
99Other glycan degradation_Homo sapiens_hsa005110.46991943
100MicroRNAs in cancer_Homo sapiens_hsa052060.46934764
101Influenza A_Homo sapiens_hsa051640.44330078
102Toll-like receptor signaling pathway_Homo sapiens_hsa046200.43054368
103Prostate cancer_Homo sapiens_hsa052150.40892850
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40450983
105Hepatitis B_Homo sapiens_hsa051610.39903105
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.39480830
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38933833
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38467504
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38300419
110Insulin resistance_Homo sapiens_hsa049310.38292079
111Apoptosis_Homo sapiens_hsa042100.38048022
112Prolactin signaling pathway_Homo sapiens_hsa049170.37709445
113Rheumatoid arthritis_Homo sapiens_hsa053230.36495527
114Lysine degradation_Homo sapiens_hsa003100.36100231
115Cysteine and methionine metabolism_Homo sapiens_hsa002700.36086638
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35418024
117Osteoclast differentiation_Homo sapiens_hsa043800.35196176
118Legionellosis_Homo sapiens_hsa051340.34563521
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.34031433
120Shigellosis_Homo sapiens_hsa051310.32836307
121Vitamin digestion and absorption_Homo sapiens_hsa049770.32814394
122Arginine and proline metabolism_Homo sapiens_hsa003300.32659174
123FoxO signaling pathway_Homo sapiens_hsa040680.31754859
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31436539
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30750890
126B cell receptor signaling pathway_Homo sapiens_hsa046620.30737658
127Glutathione metabolism_Homo sapiens_hsa004800.29181353
128Small cell lung cancer_Homo sapiens_hsa052220.29012624
129Melanoma_Homo sapiens_hsa052180.28766768
130T cell receptor signaling pathway_Homo sapiens_hsa046600.28241249
131Ribosome_Homo sapiens_hsa030100.27920587
132Metabolic pathways_Homo sapiens_hsa011000.27920548
133Axon guidance_Homo sapiens_hsa043600.27613678
134Pancreatic cancer_Homo sapiens_hsa052120.26827051
135Leishmaniasis_Homo sapiens_hsa051400.25101542
136Jak-STAT signaling pathway_Homo sapiens_hsa046300.25016020
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24742889
138TNF signaling pathway_Homo sapiens_hsa046680.22682747
139PI3K-Akt signaling pathway_Homo sapiens_hsa041510.22415376
140Ovarian steroidogenesis_Homo sapiens_hsa049130.21977694
141Malaria_Homo sapiens_hsa051440.21930379
142Phagosome_Homo sapiens_hsa041450.20931083
143Pathways in cancer_Homo sapiens_hsa052000.20167370
144Asthma_Homo sapiens_hsa053100.19893944
145Basal cell carcinoma_Homo sapiens_hsa052170.18448592
146Glycosaminoglycan degradation_Homo sapiens_hsa005310.18075265
147Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.17142426
148Serotonergic synapse_Homo sapiens_hsa047260.16761874
149Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.15524810

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