XRCC6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.31656103
2DNA strand elongation involved in DNA replication (GO:0006271)5.18952511
3nuclear pore complex assembly (GO:0051292)5.07013766
4ribosomal small subunit assembly (GO:0000028)5.02892676
5DNA strand elongation (GO:0022616)4.95467458
6telomere maintenance via semi-conservative replication (GO:0032201)4.86558389
7DNA replication initiation (GO:0006270)4.63272161
8telomere maintenance via recombination (GO:0000722)4.34459997
9mitotic recombination (GO:0006312)4.19554471
10protein localization to kinetochore (GO:0034501)4.04299974
11DNA replication checkpoint (GO:0000076)3.97975407
12DNA deamination (GO:0045006)3.95006921
13viral transcription (GO:0019083)3.90999141
14maturation of SSU-rRNA (GO:0030490)3.86279252
15nucleotide-excision repair, DNA gap filling (GO:0006297)3.82585497
16translational termination (GO:0006415)3.82154531
17regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.79230254
18IMP biosynthetic process (GO:0006188)3.78675223
19pore complex assembly (GO:0046931)3.78200311
20regulation of translational fidelity (GO:0006450)3.75537384
21mitotic sister chromatid cohesion (GO:0007064)3.75472532
22formation of translation preinitiation complex (GO:0001731)3.74757740
23telomere maintenance via telomere lengthening (GO:0010833)3.74290023
24negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.72669611
25* V(D)J recombination (GO:0033151)3.68877920
26CENP-A containing nucleosome assembly (GO:0034080)3.68128388
27regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.67115929
28DNA replication-dependent nucleosome assembly (GO:0006335)3.65747491
29DNA replication-dependent nucleosome organization (GO:0034723)3.65747491
30anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.65435649
31chromatin remodeling at centromere (GO:0031055)3.63570458
32protein localization to chromosome, centromeric region (GO:0071459)3.63197189
33nucleobase biosynthetic process (GO:0046112)3.60629758
34translational elongation (GO:0006414)3.59213101
35folic acid-containing compound biosynthetic process (GO:0009396)3.56418876
36SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.55622765
37spindle checkpoint (GO:0031577)3.49859915
38* establishment of viral latency (GO:0019043)3.48920241
39DNA replication-independent nucleosome organization (GO:0034724)3.48867397
40DNA replication-independent nucleosome assembly (GO:0006336)3.48867397
41negative regulation of chromosome segregation (GO:0051985)3.48807957
42cotranslational protein targeting to membrane (GO:0006613)3.47260243
43negative regulation of ligase activity (GO:0051352)3.46828330
44negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.46828330
45DNA synthesis involved in DNA repair (GO:0000731)3.45958268
46mitotic spindle checkpoint (GO:0071174)3.45613810
47protein targeting to ER (GO:0045047)3.45168883
48positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.45117891
49ribosomal small subunit biogenesis (GO:0042274)3.44016976
50regulation of chromosome segregation (GO:0051983)3.41781723
51negative regulation of mitotic sister chromatid separation (GO:2000816)3.39870484
52negative regulation of sister chromatid segregation (GO:0033046)3.39870484
53negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.39870484
54negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.39870484
55negative regulation of mitotic sister chromatid segregation (GO:0033048)3.39870484
56IMP metabolic process (GO:0046040)3.39264278
57deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.37684434
58mitotic chromosome condensation (GO:0007076)3.36191025
59mitotic nuclear envelope disassembly (GO:0007077)3.35120366
60mitotic spindle assembly checkpoint (GO:0007094)3.34365635
61spindle assembly checkpoint (GO:0071173)3.32591503
62tRNA aminoacylation for protein translation (GO:0006418)3.32359281
63translational initiation (GO:0006413)3.31588412
64ribosomal large subunit biogenesis (GO:0042273)3.30376770
65regulation of histone H3-K9 methylation (GO:0051570)3.29886510
66* DNA duplex unwinding (GO:0032508)3.29782059
67nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.28822618
68peptidyl-arginine omega-N-methylation (GO:0035247)3.28797486
69establishment of protein localization to endoplasmic reticulum (GO:0072599)3.28470597
70proteasome assembly (GO:0043248)3.27702371
71attachment of spindle microtubules to kinetochore (GO:0008608)3.27541929
72* DNA geometric change (GO:0032392)3.27144738
73establishment of chromosome localization (GO:0051303)3.25841117
74amino acid activation (GO:0043038)3.25268169
75tRNA aminoacylation (GO:0043039)3.25268169
76protein localization to endoplasmic reticulum (GO:0070972)3.25143341
77protein complex localization (GO:0031503)3.24830443
78purine nucleobase biosynthetic process (GO:0009113)3.24066857
79regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.24036311
80L-serine metabolic process (GO:0006563)3.19868566
81* double-strand break repair via nonhomologous end joining (GO:0006303)3.18752848
82* non-recombinational repair (GO:0000726)3.18752848
83nucleobase-containing small molecule interconversion (GO:0015949)3.16893014
84* establishment of integrated proviral latency (GO:0075713)3.16746915
85regulation of sister chromatid cohesion (GO:0007063)3.16386231
86* DNA ligation (GO:0006266)3.15404168
87ribonucleoprotein complex biogenesis (GO:0022613)3.15070584
88meiotic chromosome segregation (GO:0045132)3.14975254
89regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.14693378
90regulation of mitotic metaphase/anaphase transition (GO:0030071)3.14693378
91positive regulation of chromosome segregation (GO:0051984)3.14273415
92* somatic cell DNA recombination (GO:0016444)3.10243217
93* somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.10243217
94* telomere organization (GO:0032200)3.09496670
95regulation of sister chromatid segregation (GO:0033045)3.08388182
96regulation of mitotic sister chromatid separation (GO:0010965)3.08388182
97regulation of mitotic sister chromatid segregation (GO:0033047)3.08388182
98* telomere maintenance (GO:0000723)3.08190169
99mismatch repair (GO:0006298)3.08144980
100kinetochore organization (GO:0051383)3.07062894
101translesion synthesis (GO:0019985)3.06722948
102negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.06096716
103membrane disassembly (GO:0030397)3.04082061
104nuclear envelope disassembly (GO:0051081)3.04082061
105G1/S transition of mitotic cell cycle (GO:0000082)3.03185797
106cell cycle G1/S phase transition (GO:0044843)3.03185797
107ribosome biogenesis (GO:0042254)3.02734705
108histone exchange (GO:0043486)3.02351322
109DNA topological change (GO:0006265)3.01878111
110ATP-dependent chromatin remodeling (GO:0043044)3.01741787
111chromatin assembly or disassembly (GO:0006333)3.01596590
112spliceosomal tri-snRNP complex assembly (GO:0000244)3.01056689
113negative regulation of RNA splicing (GO:0033119)3.00683168
114cellular protein complex disassembly (GO:0043624)3.00276780
115synapsis (GO:0007129)2.99385230
116* somatic diversification of immune receptors (GO:0002200)2.98139263
117spliceosomal snRNP assembly (GO:0000387)2.97934666
118viral life cycle (GO:0019058)2.97888226
119positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.97326446
120somatic hypermutation of immunoglobulin genes (GO:0016446)2.96772998
121somatic diversification of immune receptors via somatic mutation (GO:0002566)2.96772998
122mitotic metaphase plate congression (GO:0007080)2.96501093
123histone arginine methylation (GO:0034969)2.96427701
124chromosome segregation (GO:0007059)2.96175094
125base-excision repair (GO:0006284)2.94307159
126postreplication repair (GO:0006301)2.93985812
127mitotic sister chromatid segregation (GO:0000070)2.92604707
128transcription-coupled nucleotide-excision repair (GO:0006283)2.92145080
129rRNA processing (GO:0006364)2.91084138
130nuclear-transcribed mRNA catabolic process (GO:0000956)2.89117863
131protein complex disassembly (GO:0043241)2.88290694
132regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.87885001
133pseudouridine synthesis (GO:0001522)2.87718352
134sister chromatid segregation (GO:0000819)2.87169008
135positive regulation of histone H3-K4 methylation (GO:0051571)2.86676342
136ribosome assembly (GO:0042255)2.84405161
137mRNA splicing, via spliceosome (GO:0000398)2.84220861
138RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.84220861
139RNA splicing, via transesterification reactions (GO:0000375)2.83542599
140metaphase plate congression (GO:0051310)2.82192541
141rRNA metabolic process (GO:0016072)2.82060052
142viral mRNA export from host cell nucleus (GO:0046784)2.81437361
143exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.79979637
144protein localization to chromosome (GO:0034502)2.79716679
145* DNA conformation change (GO:0071103)2.78971524
146termination of RNA polymerase II transcription (GO:0006369)2.77943177
147translation (GO:0006412)2.77381676
148negative regulation of mRNA processing (GO:0050686)2.75160047
149nuclear pore organization (GO:0006999)2.74646067
150mRNA catabolic process (GO:0006402)2.74624938

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.11697843
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.85730571
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.68816346
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.67405474
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.65386782
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.97879065
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.97558597
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.85010713
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.65529744
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.60471754
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.58418434
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.58316065
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.56945436
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.54364462
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.50341663
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.50185708
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33108606
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.28834313
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.27817804
20VDR_23849224_ChIP-Seq_CD4+_Human2.27756340
21MYC_22102868_ChIP-Seq_BL_Human2.23815067
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18541535
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17549856
24FOXP3_21729870_ChIP-Seq_TREG_Human2.14682891
25* XRN2_22483619_ChIP-Seq_HELA_Human2.11564951
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.07470608
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.04066694
28E2F1_21310950_ChIP-Seq_MCF-7_Human2.01895745
29CIITA_25753668_ChIP-Seq_RAJI_Human1.91300735
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.90706821
31* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.85911792
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.84681390
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82653567
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80811761
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80650316
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77496157
37DCP1A_22483619_ChIP-Seq_HELA_Human1.76667805
38GABP_19822575_ChIP-Seq_HepG2_Human1.75991844
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73253118
40AR_21909140_ChIP-Seq_LNCAP_Human1.72390621
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69329395
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68786491
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.66684502
44ELK1_19687146_ChIP-ChIP_HELA_Human1.62868302
45* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.59490672
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59307358
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58081357
48TTF2_22483619_ChIP-Seq_HELA_Human1.57439808
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.55563628
50* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50955200
51* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49305184
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48283939
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.45805249
54KDM5A_27292631_Chip-Seq_BREAST_Human1.43828880
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43083789
56VDR_21846776_ChIP-Seq_THP-1_Human1.41794198
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41784578
58* SRF_21415370_ChIP-Seq_HL-1_Mouse1.41331269
59PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.37240440
60* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35030583
61* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34505604
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.29235732
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.26992184
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23918011
65IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.20531104
66E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19196243
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17405005
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.16158048
69GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14956301
70TFEB_21752829_ChIP-Seq_HELA_Human1.14857921
71SPI1_23547873_ChIP-Seq_NB4_Human1.12800875
72* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10281596
73SOX17_20123909_ChIP-Seq_XEN_Mouse1.09713549
74RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07914398
75SCL_19346495_ChIP-Seq_HPC-7_Human1.07840037
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07479774
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.07126391
78HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06779212
79E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.04576552
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02817557
81ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.02745137
82* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02302850
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00682972
84MYB_26560356_Chip-Seq_TH2_Human1.00610020
85ZNF263_19887448_ChIP-Seq_K562_Human0.99727828
86* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.99493856
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98848925
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98397721
89HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97603441
90SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.94732124
91UTX_26944678_Chip-Seq_JUKART_Human0.94564835
92STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92845579
93CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92755050
94NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92736594
95* NANOG_21062744_ChIP-ChIP_HESCs_Human0.92724891
96SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92507884
97* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90918649
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90729424
99NANOG_16153702_ChIP-ChIP_HESCs_Human0.90198681
100POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89993566
101MYB_26560356_Chip-Seq_TH1_Human0.89749317
102* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89040957
103ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87879565
104ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87104657
105TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.86944736
106RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.86090132
107CHD1_26751641_Chip-Seq_LNCaP_Human0.86040002
108* MYC_18940864_ChIP-ChIP_HL60_Human0.83758074
109MAF_26560356_Chip-Seq_TH1_Human0.83743234
110GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83139193
111CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.82505778
112SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.81828329
113KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81209097
114HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.80900994
115POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.80508153
116* CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.80058743
117SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78667361
118* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.78651920
119SOX2_16153702_ChIP-ChIP_HESCs_Human0.77795548

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.91788432
2MP0003693_abnormal_embryo_hatching4.85029072
3MP0004957_abnormal_blastocyst_morpholog3.93209788
4MP0003111_abnormal_nucleus_morphology3.84478001
5MP0003077_abnormal_cell_cycle3.73244633
6MP0008057_abnormal_DNA_replication3.57896035
7MP0008058_abnormal_DNA_repair3.46116026
8MP0002396_abnormal_hematopoietic_system3.35304163
9MP0003763_abnormal_thymus_physiology2.52728316
10MP0008877_abnormal_DNA_methylation2.31533506
11* MP0008007_abnormal_cellular_replicative2.28997027
12MP0004808_abnormal_hematopoietic_stem2.06371631
13MP0001730_embryonic_growth_arrest2.03465923
14MP0006054_spinal_hemorrhage2.01433059
15* MP0000703_abnormal_thymus_morphology1.99984735
16MP0000490_abnormal_crypts_of1.98266607
17MP0008932_abnormal_embryonic_tissue1.96331085
18* MP0000350_abnormal_cell_proliferation1.93026335
19MP0003941_abnormal_skin_development1.92097436
20MP0010352_gastrointestinal_tract_polyps1.89970867
21* MP0002398_abnormal_bone_marrow1.89453993
22MP0009697_abnormal_copulation1.82886870
23MP0003786_premature_aging1.76655701
24MP0003806_abnormal_nucleotide_metabolis1.75045183
25* MP0002019_abnormal_tumor_incidence1.71147247
26* MP0002722_abnormal_immune_system1.68410557
27MP0000685_abnormal_immune_system1.66949711
28* MP0000689_abnormal_spleen_morphology1.64663374
29MP0009333_abnormal_splenocyte_physiolog1.64446664
30MP0000537_abnormal_urethra_morphology1.63876231
31MP0002166_altered_tumor_susceptibility1.57846094
32MP0005397_hematopoietic_system_phenotyp1.56939932
33MP0001545_abnormal_hematopoietic_system1.56939932
34MP0002132_abnormal_respiratory_system1.55954638
35* MP0000313_abnormal_cell_death1.50780365
36MP0010307_abnormal_tumor_latency1.49992760
37MP0005671_abnormal_response_to1.48257946
38MP0010030_abnormal_orbit_morphology1.44719591
39MP0002080_prenatal_lethality1.41264269
40MP0003123_paternal_imprinting1.40801224
41* MP0002429_abnormal_blood_cell1.38892105
42MP0001697_abnormal_embryo_size1.38217049
43MP0002095_abnormal_skin_pigmentation1.36567494
44* MP0000716_abnormal_immune_system1.36328862
45MP0001346_abnormal_lacrimal_gland1.35216503
46MP0005380_embryogenesis_phenotype1.34815489
47MP0001672_abnormal_embryogenesis/_devel1.34815489
48* MP0001800_abnormal_humoral_immune1.33729400
49MP0003315_abnormal_perineum_morphology1.30334237
50MP0004233_abnormal_muscle_weight1.29144973
51MP0002697_abnormal_eye_size1.26389661
52MP0005075_abnormal_melanosome_morpholog1.26193379
53MP0003984_embryonic_growth_retardation1.25241141
54MP0001661_extended_life_span1.22852703
55MP0010234_abnormal_vibrissa_follicle1.22604654
56MP0002088_abnormal_embryonic_growth/wei1.21504855
57MP0001835_abnormal_antigen_presentation1.21313345
58MP0009278_abnormal_bone_marrow1.19130941
59MP0003937_abnormal_limbs/digits/tail_de1.16278328
60MP0006036_abnormal_mitochondrial_physio1.15165046
61MP0002006_tumorigenesis1.14404464
62MP0005174_abnormal_tail_pigmentation1.14304877
63MP0004197_abnormal_fetal_growth/weight/1.13713067
64* MP0002420_abnormal_adaptive_immunity1.13428056
65MP0002085_abnormal_embryonic_tissue1.12192752
66MP0003567_abnormal_fetal_cardiomyocyte1.10534276
67* MP0001819_abnormal_immune_cell1.09905545
68MP0008260_abnormal_autophagy1.08436388
69MP0003221_abnormal_cardiomyocyte_apopto1.07177964
70MP0002086_abnormal_extraembryonic_tissu1.03964319
71MP0005501_abnormal_skin_physiology1.03628468
72* MP0002452_abnormal_antigen_presenting1.01450210
73MP0002084_abnormal_developmental_patter1.00322550
74MP0002111_abnormal_tail_morphology0.97430084
75MP0003121_genomic_imprinting0.96775256
76MP0002210_abnormal_sex_determination0.96426379
77MP0009703_decreased_birth_body0.95365759
78* MP0002723_abnormal_immune_serum0.95335249
79MP0002405_respiratory_system_inflammati0.92724115
80MP0003186_abnormal_redox_activity0.92624461
81MP0001853_heart_inflammation0.91182244
82MP0010155_abnormal_intestine_physiology0.90340702
83MP0002075_abnormal_coat/hair_pigmentati0.89899396
84MP0000465_gastrointestinal_hemorrhage0.89227071
85MP0001293_anophthalmia0.88924596
86MP0002163_abnormal_gland_morphology0.88901216
87MP0001529_abnormal_vocalization0.87849707
88MP0002092_abnormal_eye_morphology0.87540983
89MP0000015_abnormal_ear_pigmentation0.85458599
90MP0009785_altered_susceptibility_to0.85290500
91MP0001145_abnormal_male_reproductive0.85104609
92MP0001727_abnormal_embryo_implantation0.84420849
93MP0002233_abnormal_nose_morphology0.84272266
94MP0005623_abnormal_meninges_morphology0.83020007
95MP0004147_increased_porphyrin_level0.82753235
96MP0000358_abnormal_cell_content/0.82680768
97MP0001929_abnormal_gametogenesis0.82515968
98MP0004185_abnormal_adipocyte_glucose0.82344750
99MP0001286_abnormal_eye_development0.82002844
100MP0000858_altered_metastatic_potential0.79648451
101MP0001873_stomach_inflammation0.78470952
102MP0001849_ear_inflammation0.77689398
103MP0000579_abnormal_nail_morphology0.77525563
104MP0006035_abnormal_mitochondrial_morpho0.77157497
105MP0008789_abnormal_olfactory_epithelium0.76921012
106MP0002877_abnormal_melanocyte_morpholog0.76206905
107MP0001915_intracranial_hemorrhage0.76119473
108MP0002160_abnormal_reproductive_system0.75611876
109MP0001186_pigmentation_phenotype0.75587689
110* MP0005621_abnormal_cell_physiology0.75423507
111MP0005389_reproductive_system_phenotype0.75377250
112MP0004782_abnormal_surfactant_physiolog0.74558181
113MP0005000_abnormal_immune_tolerance0.74276335
114MP0000477_abnormal_intestine_morphology0.74235483
115MP0006292_abnormal_olfactory_placode0.73109548
116MP0003866_abnormal_defecation0.73069281
117MP0003385_abnormal_body_wall0.71533246
118MP0005076_abnormal_cell_differentiation0.71424501
119MP0000653_abnormal_sex_gland0.71346035
120* MP0005384_cellular_phenotype0.70326701
121MP0002796_impaired_skin_barrier0.70075479
122MP0005025_abnormal_response_to0.69177526
123MP0003890_abnormal_embryonic-extraembry0.69037682
124MP0005220_abnormal_exocrine_pancreas0.68780521
125MP0009672_abnormal_birth_weight0.68553112
126MP0003119_abnormal_digestive_system0.68355552
127MP0003943_abnormal_hepatobiliary_system0.67872549
128MP0002938_white_spotting0.67728183
129MP0003718_maternal_effect0.67506733
130MP0008995_early_reproductive_senescence0.66903254
131MP0003566_abnormal_cell_adhesion0.66202673
132MP0003705_abnormal_hypodermis_morpholog0.65788506
133MP0004947_skin_inflammation0.65074439
134MP0001881_abnormal_mammary_gland0.64628113
135MP0001790_abnormal_immune_system0.64609919
136MP0005387_immune_system_phenotype0.64609919
137MP0001119_abnormal_female_reproductive0.64126037
138MP0002269_muscular_atrophy0.64099668
139MP0003699_abnormal_female_reproductive0.62057794
140MP0003861_abnormal_nervous_system0.60342443
141MP0000428_abnormal_craniofacial_morphol0.60256797
142MP0002060_abnormal_skin_morphology0.60151204
143* MP0002161_abnormal_fertility/fecundity0.59919293
144MP0003698_abnormal_male_reproductive0.59439291
145MP0002009_preneoplasia0.59230269
146MP0003115_abnormal_respiratory_system0.58889416
147MP0000627_abnormal_mammary_gland0.57447739
148MP0000762_abnormal_tongue_morphology0.57359659

Predicted human phenotypes

RankGene SetZ-score
1B lymphocytopenia (HP:0010976)5.25453434
2Abnormality of B cell number (HP:0010975)5.25453434
3Abnormality of cells of the erythroid lineage (HP:0012130)4.18463313
4T lymphocytopenia (HP:0005403)4.13202642
5Reticulocytopenia (HP:0001896)4.12830017
6Abnormal number of erythroid precursors (HP:0012131)4.12631855
7Severe combined immunodeficiency (HP:0004430)4.08347279
8Hypoplasia of the thymus (HP:0000778)3.99000425
9Birth length less than 3rd percentile (HP:0003561)3.86300220
10Combined immunodeficiency (HP:0005387)3.79703000
11Microvesicular hepatic steatosis (HP:0001414)3.79633789
12Thyroiditis (HP:0100646)3.79548280
13Abnormality of T cell number (HP:0011839)3.75481785
14Panhypogammaglobulinemia (HP:0003139)3.47078361
15Aplastic anemia (HP:0001915)3.35816099
16Abnormality of glycolysis (HP:0004366)3.33538760
17Multiple enchondromatosis (HP:0005701)3.26639623
18IgM deficiency (HP:0002850)3.20968627
19Increased serum pyruvate (HP:0003542)3.12630494
20Colon cancer (HP:0003003)3.08747353
21Recurrent viral infections (HP:0004429)3.06648407
22Chromsome breakage (HP:0040012)3.04964258
23IgG deficiency (HP:0004315)2.97154185
24Abnormality of T cells (HP:0002843)2.96608046
25Spastic diplegia (HP:0001264)2.94822049
26Cortical dysplasia (HP:0002539)2.90144060
27Medulloblastoma (HP:0002885)2.87951065
28Progressive external ophthalmoplegia (HP:0000590)2.83886552
29Thrombocytosis (HP:0001894)2.79630161
30Nephroblastoma (Wilms tumor) (HP:0002667)2.79260025
31Abnormality of chromosome stability (HP:0003220)2.77220434
32Lymphoma (HP:0002665)2.77063412
33Chromosomal breakage induced by crosslinking agents (HP:0003221)2.73246734
34Granulocytopenia (HP:0001913)2.72878668
35Shoulder girdle muscle weakness (HP:0003547)2.68554831
36Abnormality of the anterior horn cell (HP:0006802)2.67372953
37Degeneration of anterior horn cells (HP:0002398)2.67372953
38Oral leukoplakia (HP:0002745)2.66536795
39Patellar aplasia (HP:0006443)2.64641918
40Recurrent bronchitis (HP:0002837)2.63081582
41Embryonal renal neoplasm (HP:0011794)2.61659040
42Eosinophilia (HP:0001880)2.61525171
43Myelodysplasia (HP:0002863)2.57469309
44Progressive muscle weakness (HP:0003323)2.57350904
45Ependymoma (HP:0002888)2.54229161
46Macrocytic anemia (HP:0001972)2.53853913
47Hypoproteinemia (HP:0003075)2.52966594
48Selective tooth agenesis (HP:0001592)2.47161958
49Aplasia/Hypoplasia of the patella (HP:0006498)2.46757019
50Pallor (HP:0000980)2.46561105
51Cellular immunodeficiency (HP:0005374)2.46429063
52Abnormality of the preputium (HP:0100587)2.45490513
5311 pairs of ribs (HP:0000878)2.43086334
54Premature graying of hair (HP:0002216)2.40087935
55Acute lymphatic leukemia (HP:0006721)2.40012796
56Aplasia/Hypoplasia of the thymus (HP:0010515)2.38957717
57Verrucae (HP:0200043)2.38159118
58Papilloma (HP:0012740)2.38159118
59Volvulus (HP:0002580)2.37866310
60Basal cell carcinoma (HP:0002671)2.37114618
61Type I transferrin isoform profile (HP:0003642)2.36313734
62Cerebral hypomyelination (HP:0006808)2.33440883
63Agammaglobulinemia (HP:0004432)2.32546185
64Breast hypoplasia (HP:0003187)2.30335859
65Horseshoe kidney (HP:0000085)2.29059665
66Bone marrow hypocellularity (HP:0005528)2.26764053
67Abnormality of the labia minora (HP:0012880)2.26464740
68Absent thumb (HP:0009777)2.25934304
69Carpal bone hypoplasia (HP:0001498)2.25678833
70Agnosia (HP:0010524)2.21213565
71Abnormality of the umbilical cord (HP:0010881)2.20653376
72High anterior hairline (HP:0009890)2.18587896
73Facial cleft (HP:0002006)2.18197682
74Amaurosis fugax (HP:0100576)2.17439047
75Abnormality of the heme biosynthetic pathway (HP:0010472)2.16946454
76Abnormality of eosinophils (HP:0001879)2.16825142
77Secondary amenorrhea (HP:0000869)2.15674431
78Meckel diverticulum (HP:0002245)2.15371411
79Hypoplasia of the capital femoral epiphysis (HP:0003090)2.14598638
80Neoplasm of the pancreas (HP:0002894)2.12891646
81Abnormality of the ileum (HP:0001549)2.12615092
82Broad distal phalanx of finger (HP:0009836)2.12529157
83Aplasia/Hypoplasia of the sacrum (HP:0008517)2.11637774
84Trismus (HP:0000211)2.10590527
85Pancytopenia (HP:0001876)2.09050615
86Microretrognathia (HP:0000308)2.08951082
87Abnormality of the duodenum (HP:0002246)2.08167572
88Cholecystitis (HP:0001082)2.07524290
89Abnormal gallbladder physiology (HP:0012438)2.07524290
90Abnormal lung lobation (HP:0002101)2.07123424
91Rough bone trabeculation (HP:0100670)2.04520204
92Rhabdomyosarcoma (HP:0002859)2.04404699
93Aplasia/Hypoplasia of the uvula (HP:0010293)2.03371259
94Pelvic girdle muscle weakness (HP:0003749)2.02580217
95Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.01000624
96Decreased activity of mitochondrial respiratory chain (HP:0008972)2.01000624
97Ragged-red muscle fibers (HP:0003200)2.00950978
98Abnormality of the carotid arteries (HP:0005344)2.00356179
99Absent radius (HP:0003974)2.00259077
100Chronic otitis media (HP:0000389)1.99432143
101Squamous cell carcinoma (HP:0002860)1.99053685
102Postnatal microcephaly (HP:0005484)1.98898901
103Gout (HP:0001997)1.98883312
104Increased serum lactate (HP:0002151)1.98149965
105Increased nuchal translucency (HP:0010880)1.97500535
106Cellulitis (HP:0100658)1.95828692
107Sloping forehead (HP:0000340)1.94669071
108Abnormality of the fetal cardiovascular system (HP:0010948)1.92421038
109Abnormal umbilical cord blood vessels (HP:0011403)1.92421038
110Single umbilical artery (HP:0001195)1.92421038
111Poikiloderma (HP:0001029)1.91649623
112Abnormality of T cell physiology (HP:0011840)1.91394199
113Choanal atresia (HP:0000453)1.91385218
114Abnormality of the thymus (HP:0000777)1.89566758
115Proximal placement of thumb (HP:0009623)1.88513562
116Small intestinal stenosis (HP:0012848)1.88401861
117Duodenal stenosis (HP:0100867)1.88401861
118Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87864817
119Abnormal protein N-linked glycosylation (HP:0012347)1.87864817
120Abnormal protein glycosylation (HP:0012346)1.87864817
121Abnormal glycosylation (HP:0012345)1.87864817
122Absent epiphyses (HP:0010577)1.87800223
123Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.87800223
124Astrocytoma (HP:0009592)1.87175822
125Abnormality of the astrocytes (HP:0100707)1.87175822
126Premature ovarian failure (HP:0008209)1.86332055
127Glioma (HP:0009733)1.86066577
128Abnormal number of incisors (HP:0011064)1.85729365
129Muscle fiber atrophy (HP:0100295)1.84264493
130Reduced antithrombin III activity (HP:0001976)1.83498105
131Aplasia involving forearm bones (HP:0009822)1.82949137
132Absent forearm bone (HP:0003953)1.82949137
133Microglossia (HP:0000171)1.82008945
134Increased hepatocellular lipid droplets (HP:0006565)1.80874444
135Neoplasm of the colon (HP:0100273)1.79881602
136Type 2 muscle fiber atrophy (HP:0003554)1.79864327
137Abnormality of the fingertips (HP:0001211)1.78450796
138Cafe-au-lait spot (HP:0000957)1.78448548
139Abnormality of methionine metabolism (HP:0010901)1.78114784
140Abnormality of DNA repair (HP:0003254)1.77773036
141Absent rod-and cone-mediated responses on ERG (HP:0007688)1.76863875
142Meningitis (HP:0001287)1.76624383
143Abnormalities of placenta or umbilical cord (HP:0001194)1.75819080
144Orthostatic hypotension (HP:0001278)1.75726639
145Overlapping toe (HP:0001845)1.74877358
146Deviation of the thumb (HP:0009603)1.74843141
147Ovarian neoplasm (HP:0100615)1.74182509
148Lymphopenia (HP:0001888)1.74091966
149Abnormality of cells of the lymphoid lineage (HP:0012140)1.73690638
150Abnormality of the musculature of the pelvis (HP:0001469)1.72727594
151Abnormality of the hip-girdle musculature (HP:0001445)1.72727594
152Asplenia (HP:0001746)1.71638190
153Prominent metopic ridge (HP:0005487)1.71380691
154Ectopic kidney (HP:0000086)1.71276362
155Abnormality of the calcaneus (HP:0008364)1.67367450
156Acute encephalopathy (HP:0006846)1.66136710
157Atresia of the external auditory canal (HP:0000413)1.65948846
158Abnormality of cochlea (HP:0000375)1.65948116
159Abnormal mitochondria in muscle tissue (HP:0008316)1.65010978
160Triphalangeal thumb (HP:0001199)1.64868854
161Glossoptosis (HP:0000162)1.64804409
162Atrophy/Degeneration involving motor neurons (HP:0007373)1.64370921
163Embryonal neoplasm (HP:0002898)1.62330600

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.97822162
2BUB13.33550335
3MAP3K103.26400177
4WEE13.23114370
5PBK3.17603207
6VRK23.01631905
7EEF2K2.74541411
8PASK2.74140063
9NEK22.52209450
10EIF2AK12.44257523
11FLT32.24998832
12EIF2AK32.22058643
13BRSK22.16025190
14RPS6KB22.09832870
15SRPK12.07022830
16SMG12.04715189
17TLK11.99159819
18ACVR1B1.98147587
19MAP4K11.92701594
20VRK11.90432600
21NME21.87396962
22STK161.78899473
23TSSK61.77095441
24ATR1.66956472
25TESK21.64015742
26TTK1.63498193
27MKNK11.63058218
28STK41.52725745
29TRIM281.52143801
30TAF11.50256386
31CDK41.49565548
32AURKB1.48311380
33SCYL21.46626972
34PLK11.44908227
35PLK41.43212159
36PKN21.41288635
37STK101.39692846
38PDK21.39376538
39BCR1.37225984
40NEK11.36759571
41CDK121.34413874
42CDK71.30444235
43GRK61.28613154
44BRSK11.27229318
45RPS6KA41.27123779
46MKNK21.25490172
47DYRK31.24041252
48CCNB11.19308792
49MAPKAPK31.16805864
50CHEK21.15606100
51PIM11.14226282
52ZAP701.12885876
53TGFBR11.12711303
54PLK31.07112471
55ZAK1.06047782
56BTK1.05088341
57NME11.04705081
58* CHEK11.04036745
59ALK0.99283716
60BRD40.98846316
61CSF1R0.94868736
62LRRK20.92854830
63TEC0.91739128
64MAP3K80.91002244
65MST1R0.89489583
66ERBB40.89462351
67CLK10.89200187
68CDK80.84713418
69BCKDK0.82337094
70ATM0.80807796
71AURKA0.79700337
72DAPK10.79482754
73SYK0.79158367
74* CDK20.71494239
75TXK0.70101136
76MELK0.68843475
77CDK190.67922918
78CSNK1G10.66375086
79CDK60.63399135
80BRAF0.63058566
81CSNK2A20.62610365
82KDR0.62004764
83KIT0.61906512
84PAK40.60902026
85RPS6KA50.57834631
86MST40.56138513
87YES10.55619075
88NLK0.55550711
89CDK90.55264400
90CSNK2A10.54756004
91EPHA20.54303275
92CDK180.52844594
93ITK0.52738087
94AKT20.52587545
95NUAK10.52198154
96CDK10.51922131
97CDK11A0.50896553
98MAPK110.50418305
99PNCK0.50166837
100CDK150.49113746
101CDK140.48198696
102PIM20.47679718
103LIMK10.47248073
104MET0.46764709
105LYN0.44613913
106RPS6KB10.43817547
107ILK0.43543239
108STK38L0.42268858
109STK30.42011612
110CSNK1E0.41944916
111FGFR10.41695119
112LCK0.40823725
113CSNK1G30.40797609
114BLK0.39822445
115EIF2AK20.39340287
116TESK10.38287094
117IRAK30.37143876
118ICK0.36767905
119CSNK1G20.36605188
120IRAK40.36399659
121HIPK20.35957043
122TRIB30.35854846
123JAK30.35744448
124STK240.34414050
125PRKCI0.33880166
126CSNK1A1L0.32028737
127MARK30.31710318
128PAK10.31465916
129* PRKDC0.29759935
130ERBB30.29489377
131RPS6KA60.27868937
132LATS20.27860061
133PDK30.26977025
134PDK40.26977025
135MAPK40.26041580
136KSR10.23160987
137PLK20.22821235
138MAPKAPK50.22211558
139LATS10.21859437
140MAP3K120.21137873

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.28064697
2Mismatch repair_Homo sapiens_hsa034304.43353720
3Ribosome_Homo sapiens_hsa030103.43388232
4Base excision repair_Homo sapiens_hsa034103.38686619
5Spliceosome_Homo sapiens_hsa030403.14778358
6Homologous recombination_Homo sapiens_hsa034403.02285257
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.00273581
8* Non-homologous end-joining_Homo sapiens_hsa034502.96147092
9Proteasome_Homo sapiens_hsa030502.80727035
10Nucleotide excision repair_Homo sapiens_hsa034202.76231117
11RNA transport_Homo sapiens_hsa030132.54530573
12Cell cycle_Homo sapiens_hsa041102.52622046
13One carbon pool by folate_Homo sapiens_hsa006702.51825498
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.50794702
15RNA polymerase_Homo sapiens_hsa030202.49606874
16Primary immunodeficiency_Homo sapiens_hsa053402.38430748
17Pyrimidine metabolism_Homo sapiens_hsa002402.32143724
18Fanconi anemia pathway_Homo sapiens_hsa034602.04731992
19RNA degradation_Homo sapiens_hsa030181.89730626
20Basal transcription factors_Homo sapiens_hsa030221.75404124
21Systemic lupus erythematosus_Homo sapiens_hsa053221.64861637
22Protein export_Homo sapiens_hsa030601.61587190
23mRNA surveillance pathway_Homo sapiens_hsa030151.53992005
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.39984828
25Fatty acid elongation_Homo sapiens_hsa000621.37836129
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.35835719
27Purine metabolism_Homo sapiens_hsa002301.27482745
28p53 signaling pathway_Homo sapiens_hsa041151.23023135
29Antigen processing and presentation_Homo sapiens_hsa046121.18266956
30Propanoate metabolism_Homo sapiens_hsa006401.07829054
31Viral carcinogenesis_Homo sapiens_hsa052031.07754029
32Selenocompound metabolism_Homo sapiens_hsa004501.07269477
33Vitamin B6 metabolism_Homo sapiens_hsa007501.06126053
34Epstein-Barr virus infection_Homo sapiens_hsa051691.05148667
35Steroid biosynthesis_Homo sapiens_hsa001001.04460964
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04289031
37Pentose phosphate pathway_Homo sapiens_hsa000301.04119075
38Herpes simplex infection_Homo sapiens_hsa051680.99724596
39Folate biosynthesis_Homo sapiens_hsa007900.93967699
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92260563
41Drug metabolism - other enzymes_Homo sapiens_hsa009830.87106997
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81939256
43N-Glycan biosynthesis_Homo sapiens_hsa005100.78649796
44HTLV-I infection_Homo sapiens_hsa051660.73722416
45Biosynthesis of amino acids_Homo sapiens_hsa012300.72492408
46Alcoholism_Homo sapiens_hsa050340.71812774
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.69869622
48Thyroid cancer_Homo sapiens_hsa052160.69606313
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69043690
50Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67525776
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65505062
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65478268
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64660889
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64335468
55Hematopoietic cell lineage_Homo sapiens_hsa046400.63747550
56Sulfur relay system_Homo sapiens_hsa041220.61047747
57Carbon metabolism_Homo sapiens_hsa012000.60947304
58Measles_Homo sapiens_hsa051620.60137288
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.59729043
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.58609561
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58235915
62Oxidative phosphorylation_Homo sapiens_hsa001900.58182622
63B cell receptor signaling pathway_Homo sapiens_hsa046620.55578900
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.55229952
65Legionellosis_Homo sapiens_hsa051340.53932200
66Arginine and proline metabolism_Homo sapiens_hsa003300.52335090
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51970049
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51720451
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50253021
70Oocyte meiosis_Homo sapiens_hsa041140.49377577
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47392098
72Fatty acid metabolism_Homo sapiens_hsa012120.46779615
73Small cell lung cancer_Homo sapiens_hsa052220.45801281
74Parkinsons disease_Homo sapiens_hsa050120.43583597
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43449736
76T cell receptor signaling pathway_Homo sapiens_hsa046600.42789437
77Adherens junction_Homo sapiens_hsa045200.41535017
78Chronic myeloid leukemia_Homo sapiens_hsa052200.40440138
79Acute myeloid leukemia_Homo sapiens_hsa052210.40302625
80Colorectal cancer_Homo sapiens_hsa052100.40274747
81Huntingtons disease_Homo sapiens_hsa050160.40072414
82MicroRNAs in cancer_Homo sapiens_hsa052060.38538806
83Apoptosis_Homo sapiens_hsa042100.36929070
84Bladder cancer_Homo sapiens_hsa052190.36849571
85Hepatitis B_Homo sapiens_hsa051610.36368835
86Hippo signaling pathway_Homo sapiens_hsa043900.35086571
87Glutathione metabolism_Homo sapiens_hsa004800.34820164
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31032692
89Pyruvate metabolism_Homo sapiens_hsa006200.30780791
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30200375
91Non-small cell lung cancer_Homo sapiens_hsa052230.29800699
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.29098214
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27586818
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27506806
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27133577
96Phenylalanine metabolism_Homo sapiens_hsa003600.26663835
97Arginine biosynthesis_Homo sapiens_hsa002200.24757348
98Metabolic pathways_Homo sapiens_hsa011000.24068943
99Lysine degradation_Homo sapiens_hsa003100.23560301
100TGF-beta signaling pathway_Homo sapiens_hsa043500.23551897
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23523492
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.23373691
103Galactose metabolism_Homo sapiens_hsa000520.23166001
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22852061
105Alzheimers disease_Homo sapiens_hsa050100.22626118
106Notch signaling pathway_Homo sapiens_hsa043300.21723547
107Shigellosis_Homo sapiens_hsa051310.21634699
108Basal cell carcinoma_Homo sapiens_hsa052170.18786829
109beta-Alanine metabolism_Homo sapiens_hsa004100.17582461
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16585674
111Vibrio cholerae infection_Homo sapiens_hsa051100.16557400
112Influenza A_Homo sapiens_hsa051640.16483850
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.16259105
114Fructose and mannose metabolism_Homo sapiens_hsa000510.15231113
115Wnt signaling pathway_Homo sapiens_hsa043100.14632536
116Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.13464980
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.13098945
118Pancreatic cancer_Homo sapiens_hsa052120.13086384
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.12293299
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.12144721
121Prostate cancer_Homo sapiens_hsa052150.11877524
122Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.11546161
123Pathways in cancer_Homo sapiens_hsa052000.10223903
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.09049962
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.08445059
126FoxO signaling pathway_Homo sapiens_hsa040680.06226988
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.05997341

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