XRCC6P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.81698375
2positive regulation of prostaglandin secretion (GO:0032308)5.74332873
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.74192033
4cytidine metabolic process (GO:0046087)5.36678301
5cytidine catabolic process (GO:0006216)5.36678301
6cytidine deamination (GO:0009972)5.36678301
7regulation of prostaglandin secretion (GO:0032306)4.72165714
8pyrimidine ribonucleoside catabolic process (GO:0046133)4.45924156
9positive regulation of T cell cytokine production (GO:0002726)4.16710266
10rRNA modification (GO:0000154)3.94800978
11positive regulation of icosanoid secretion (GO:0032305)3.88657654
12positive regulation of fatty acid transport (GO:2000193)3.83988942
13positive regulation of heat generation (GO:0031652)3.73634122
14rRNA catabolic process (GO:0016075)3.70858107
15Arp2/3 complex-mediated actin nucleation (GO:0034314)3.69910973
16actin nucleation (GO:0045010)3.66919325
17rRNA methylation (GO:0031167)3.63126305
18positive regulation of defense response to virus by host (GO:0002230)3.52002441
19RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.47984526
20proteasome assembly (GO:0043248)3.41771498
21regulation of fever generation (GO:0031620)3.37856709
22nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.29168341
23negative regulation of telomere maintenance (GO:0032205)3.28330987
24branched-chain amino acid catabolic process (GO:0009083)3.25950370
25DNA replication checkpoint (GO:0000076)3.23641544
26maturation of 5.8S rRNA (GO:0000460)3.22496786
27DNA ligation (GO:0006266)3.22098859
28respiratory chain complex IV assembly (GO:0008535)3.20898367
29water-soluble vitamin biosynthetic process (GO:0042364)3.19214232
30L-fucose catabolic process (GO:0042355)3.18076951
31fucose catabolic process (GO:0019317)3.18076951
32L-fucose metabolic process (GO:0042354)3.18076951
33exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.17705930
34DNA double-strand break processing (GO:0000729)3.17249425
35positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.99465070
36regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.98214983
37regulation of mitotic spindle checkpoint (GO:1903504)2.98214983
38positive regulation of natural killer cell mediated immunity (GO:0002717)2.96062359
39positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.95505071
40cytochrome complex assembly (GO:0017004)2.95265011
41positive regulation of T cell mediated cytotoxicity (GO:0001916)2.89622453
42regulation of T cell cytokine production (GO:0002724)2.88971994
43response to X-ray (GO:0010165)2.88415327
44cellular response to interleukin-15 (GO:0071350)2.87620685
45negative regulation of DNA-dependent DNA replication (GO:2000104)2.86582154
46male meiosis (GO:0007140)2.81622478
47positive regulation of T cell mediated immunity (GO:0002711)2.80819437
48cilium or flagellum-dependent cell motility (GO:0001539)2.79496007
49regulation of interleukin-12 biosynthetic process (GO:0045075)2.78569840
50protein deneddylation (GO:0000338)2.77827101
51sulfation (GO:0051923)2.77696494
52multicellular organism reproduction (GO:0032504)2.75588445
53branched-chain amino acid metabolic process (GO:0009081)2.71613215
54regulation of heat generation (GO:0031650)2.70643501
55negative regulation of reactive oxygen species metabolic process (GO:2000378)2.70013460
56regulation of icosanoid secretion (GO:0032303)2.66122995
57hyperosmotic salinity response (GO:0042538)2.65305034
58regulation of nuclear cell cycle DNA replication (GO:0033262)2.65013533
59regulation of response to tumor cell (GO:0002834)2.63230222
60positive regulation of response to tumor cell (GO:0002836)2.63230222
61positive regulation of immune response to tumor cell (GO:0002839)2.63230222
62regulation of immune response to tumor cell (GO:0002837)2.63230222
63regulation of DNA endoreduplication (GO:0032875)2.61982465
64cullin deneddylation (GO:0010388)2.60640018
65CENP-A containing nucleosome assembly (GO:0034080)2.60384920
66positive regulation of osteoclast differentiation (GO:0045672)2.60377782
67protein complex biogenesis (GO:0070271)2.60325900
68somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.58663614
69isotype switching (GO:0045190)2.58663614
70somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.58663614
71DNA catabolic process, exonucleolytic (GO:0000738)2.58545173
72regulation of T cell chemotaxis (GO:0010819)2.58332672
73positive regulation of T cell chemotaxis (GO:0010820)2.58332672
74mitochondrial respiratory chain complex assembly (GO:0033108)2.55566128
75chromatin remodeling at centromere (GO:0031055)2.55541111
76histone exchange (GO:0043486)2.53339528
77somatic diversification of immune receptors via somatic mutation (GO:0002566)2.53029812
78somatic hypermutation of immunoglobulin genes (GO:0016446)2.53029812
79positive regulation of cell killing (GO:0031343)2.51056498
80interleukin-1-mediated signaling pathway (GO:0070498)2.49485307
81regulation of leukocyte mediated cytotoxicity (GO:0001910)2.49332596
82transcription elongation from RNA polymerase III promoter (GO:0006385)2.47509583
83termination of RNA polymerase III transcription (GO:0006386)2.47509583
84regulation of T cell mediated cytotoxicity (GO:0001914)2.47446289
85L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.47222052
86regulation of immunoglobulin secretion (GO:0051023)2.47153259
87histone mRNA metabolic process (GO:0008334)2.46947971
88regulation of mesoderm development (GO:2000380)2.46430968
89axoneme assembly (GO:0035082)2.46164275
90behavioral response to nicotine (GO:0035095)2.45998946
91detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.42691951
92cellular ketone body metabolic process (GO:0046950)2.40796530
93S-adenosylmethionine metabolic process (GO:0046500)2.39408424
94response to lipoprotein particle (GO:0055094)2.38828588
95piRNA metabolic process (GO:0034587)2.38427703
96iron-sulfur cluster assembly (GO:0016226)2.36604638
97metallo-sulfur cluster assembly (GO:0031163)2.36604638
98amino acid salvage (GO:0043102)2.36276618
99L-methionine salvage (GO:0071267)2.36276618
100L-methionine biosynthetic process (GO:0071265)2.36276618

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.76232985
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.65964190
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.23173792
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.10406851
5E2F7_22180533_ChIP-Seq_HELA_Human3.09962553
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.09144632
7ZNF274_21170338_ChIP-Seq_K562_Hela3.01568084
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.78265618
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.49752539
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.32909026
11VDR_22108803_ChIP-Seq_LS180_Human2.30019944
12MYC_18940864_ChIP-ChIP_HL60_Human2.27577028
13VDR_23849224_ChIP-Seq_CD4+_Human2.21168969
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.13805294
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06279243
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.01335031
17IGF1R_20145208_ChIP-Seq_DFB_Human2.00400589
18ELF1_17652178_ChIP-ChIP_JURKAT_Human1.97522242
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.93614183
20SRF_21415370_ChIP-Seq_HL-1_Mouse1.87654796
21FOXP3_21729870_ChIP-Seq_TREG_Human1.82640209
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77863839
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76745203
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76653162
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.75784089
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.70294358
27ELK1_19687146_ChIP-ChIP_HELA_Human1.70053684
28AR_20517297_ChIP-Seq_VCAP_Human1.66914516
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.62939501
30EWS_26573619_Chip-Seq_HEK293_Human1.61826329
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.61110993
32FOXA1_27270436_Chip-Seq_PROSTATE_Human1.61051296
33FOXA1_25329375_ChIP-Seq_VCAP_Human1.61051296
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60952291
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.59551721
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.58803876
37FUS_26573619_Chip-Seq_HEK293_Human1.48609303
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47601641
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43073762
40CBP_20019798_ChIP-Seq_JUKART_Human1.43073762
41GATA3_26560356_Chip-Seq_TH2_Human1.36159182
42TP53_22573176_ChIP-Seq_HFKS_Human1.35932689
43TAF15_26573619_Chip-Seq_HEK293_Human1.35748511
44AUTS2_25519132_ChIP-Seq_293T-REX_Human1.35552871
45FOXA1_21572438_ChIP-Seq_LNCaP_Human1.34736384
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34614423
47EGR1_23403033_ChIP-Seq_LIVER_Mouse1.33840398
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33518327
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32530775
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31864054
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31271117
52ER_23166858_ChIP-Seq_MCF-7_Human1.30623561
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.29719041
54NCOR_22424771_ChIP-Seq_293T_Human1.28288150
55PHF8_20622853_ChIP-Seq_HELA_Human1.27984056
56STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.26545031
57HTT_18923047_ChIP-ChIP_STHdh_Human1.24907088
58SOX2_19829295_ChIP-Seq_ESCs_Human1.24864547
59NANOG_19829295_ChIP-Seq_ESCs_Human1.24864547
60CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22432729
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.21097254
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.20954036
63P300_19829295_ChIP-Seq_ESCs_Human1.20757830
64FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.20721910
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19129300
66GBX2_23144817_ChIP-Seq_PC3_Human1.18755177
67GATA6_21074721_ChIP-Seq_CACO-2_Human1.18525142
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18510983
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18235701
70NFYB_21822215_ChIP-Seq_K562_Human1.17697207
71MYC_19829295_ChIP-Seq_ESCs_Human1.17301124
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17138859
73CREB1_15753290_ChIP-ChIP_HEK293T_Human1.17060349
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.16100152
75FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15319033
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15253932
77CDX2_22108803_ChIP-Seq_LS180_Human1.13811948
78GATA3_21878914_ChIP-Seq_MCF-7_Human1.12882205
79HOXB7_26014856_ChIP-Seq_BT474_Human1.12581577
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11991032
81GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.11412479
82GATA3_26560356_Chip-Seq_TH1_Human1.11278048
83IRF1_19129219_ChIP-ChIP_H3396_Human1.09947669
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09208625
85TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09084555
86RBPJ_21746931_ChIP-Seq_IB4_Human1.07856833
87NFYA_21822215_ChIP-Seq_K562_Human1.07032484
88GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.06788312
89CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.06702821
90HNFA_21074721_ChIP-Seq_CACO-2_Human1.04994683
91TCF4_22108803_ChIP-Seq_LS180_Human1.04430129
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03921009
93FOXH1_21741376_ChIP-Seq_EPCs_Human1.02937514
94EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02521722
95ETV1_20927104_ChIP-Seq_GIST48_Human0.99620039
96AR_21572438_ChIP-Seq_LNCaP_Human0.99605793
97TAF2_19829295_ChIP-Seq_ESCs_Human0.99165555
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98230348
99HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97625614
100CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96368265

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.88750223
2MP0003786_premature_aging3.20385603
3MP0002163_abnormal_gland_morphology2.86958640
4MP0005671_abnormal_response_to2.84319881
5MP0005360_urolithiasis2.57559825
6MP0008877_abnormal_DNA_methylation2.48939064
7MP0002876_abnormal_thyroid_physiology2.35829221
8MP0006072_abnormal_retinal_apoptosis2.26635583
9MP0000685_abnormal_immune_system2.23573009
10MP0005379_endocrine/exocrine_gland_phen2.19757501
11MP0002102_abnormal_ear_morphology2.06476164
12MP0008007_abnormal_cellular_replicative2.03999649
13MP0005410_abnormal_fertilization2.02196190
14MP0009333_abnormal_splenocyte_physiolog1.98000612
15MP0004043_abnormal_pH_regulation1.95026608
16MP0002736_abnormal_nociception_after1.94955895
17MP0001968_abnormal_touch/_nociception1.88501056
18MP0000427_abnormal_hair_cycle1.79505658
19MP0000372_irregular_coat_pigmentation1.74665699
20MP0009785_altered_susceptibility_to1.68729543
21MP0003878_abnormal_ear_physiology1.66981646
22MP0005377_hearing/vestibular/ear_phenot1.66981646
23MP0010094_abnormal_chromosome_stability1.66315318
24MP0008995_early_reproductive_senescence1.63183701
25MP0002148_abnormal_hypersensitivity_rea1.62575149
26MP0003693_abnormal_embryo_hatching1.62203698
27MP0002234_abnormal_pharynx_morphology1.59737411
28MP0003806_abnormal_nucleotide_metabolis1.56558052
29MP0005503_abnormal_tendon_morphology1.51486674
30MP0001661_extended_life_span1.49964678
31MP0006292_abnormal_olfactory_placode1.38421847
32MP0005389_reproductive_system_phenotype1.38257224
33MP0001873_stomach_inflammation1.37755522
34MP0003111_abnormal_nucleus_morphology1.37263304
35MP0005253_abnormal_eye_physiology1.37022377
36MP0002009_preneoplasia1.36670125
37MP0003724_increased_susceptibility_to1.33003949
38MP0005310_abnormal_salivary_gland1.31376553
39MP0008872_abnormal_physiological_respon1.31054778
40MP0005000_abnormal_immune_tolerance1.30795346
41MP0001346_abnormal_lacrimal_gland1.29765827
42MP0005084_abnormal_gallbladder_morpholo1.29150841
43MP0003787_abnormal_imprinting1.28547578
44MP0005551_abnormal_eye_electrophysiolog1.28500792
45MP0001929_abnormal_gametogenesis1.28333317
46MP0005187_abnormal_penis_morphology1.28317819
47MP0005645_abnormal_hypothalamus_physiol1.27865932
48MP0001919_abnormal_reproductive_system1.27089966
49MP0004885_abnormal_endolymph1.25955705
50MP0002405_respiratory_system_inflammati1.24735407
51MP0001835_abnormal_antigen_presentation1.22396416
52MP0002160_abnormal_reproductive_system1.21860036
53MP0008875_abnormal_xenobiotic_pharmacok1.21728012
54MP0004957_abnormal_blastocyst_morpholog1.19684687
55MP0008058_abnormal_DNA_repair1.19434432
56MP0010386_abnormal_urinary_bladder1.16599948
57MP0001501_abnormal_sleep_pattern1.13571748
58MP0003252_abnormal_bile_duct1.11999842
59MP0000538_abnormal_urinary_bladder1.10969675
60MP0003763_abnormal_thymus_physiology1.09947852
61MP0001800_abnormal_humoral_immune1.08371288
62MP0001790_abnormal_immune_system1.06746886
63MP0005387_immune_system_phenotype1.06746886
64MP0002723_abnormal_immune_serum1.04764256
65MP0003646_muscle_fatigue1.04242942
66MP0003436_decreased_susceptibility_to1.03811334
67MP0001533_abnormal_skeleton_physiology1.02806781
68MP0002138_abnormal_hepatobiliary_system1.00799706
69MP0005646_abnormal_pituitary_gland1.00136454
70MP0005332_abnormal_amino_acid0.97150747
71MP0002166_altered_tumor_susceptibility0.97139496
72MP0002837_dystrophic_cardiac_calcinosis0.96343527
73MP0002006_tumorigenesis0.92715106
74MP0001119_abnormal_female_reproductive0.91493434
75MP0003045_fibrosis0.89732143
76MP0002277_abnormal_respiratory_mucosa0.88714721
77MP0000647_abnormal_sebaceous_gland0.88308934
78MP0000689_abnormal_spleen_morphology0.88034008
79MP0009384_cardiac_valve_regurgitation0.87935697
80MP0009697_abnormal_copulation0.87393074
81MP0003698_abnormal_male_reproductive0.87034682
82MP0006082_CNS_inflammation0.85756315
83MP0003718_maternal_effect0.83625069
84MP0008932_abnormal_embryonic_tissue0.83333996
85MP0001765_abnormal_ion_homeostasis0.82881482
86MP0006035_abnormal_mitochondrial_morpho0.82722932
87MP0006276_abnormal_autonomic_nervous0.82384339
88MP0001881_abnormal_mammary_gland0.81938940
89MP0002420_abnormal_adaptive_immunity0.80452469
90MP0001845_abnormal_inflammatory_respons0.79741363
91MP0000383_abnormal_hair_follicle0.79177620
92MP0001819_abnormal_immune_cell0.79091020
93MP0004134_abnormal_chest_morphology0.76558121
94MP0000653_abnormal_sex_gland0.75565535
95MP0000230_abnormal_systemic_arterial0.73816182
96MP0001542_abnormal_bone_strength0.73748996
97MP0002210_abnormal_sex_determination0.73503643
98MP0001485_abnormal_pinna_reflex0.73472189
99MP0002398_abnormal_bone_marrow0.72555973
100MP0002693_abnormal_pancreas_physiology0.71925623

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the renal cortex (HP:0011035)4.11218080
2Tongue fasciculations (HP:0001308)3.56258435
3Renal cortical cysts (HP:0000803)3.56003403
4Pancreatic cysts (HP:0001737)3.49110816
5IgG deficiency (HP:0004315)3.37271061
6Abnormality of T cell number (HP:0011839)3.16802337
7Increased IgM level (HP:0003496)3.01071699
83-Methylglutaconic aciduria (HP:0003535)2.96123046
9Abolished electroretinogram (ERG) (HP:0000550)2.94058618
10Muscle fibrillation (HP:0010546)2.90319465
11Attenuation of retinal blood vessels (HP:0007843)2.87276760
12Pancreatic fibrosis (HP:0100732)2.79060491
13Abnormality of midbrain morphology (HP:0002418)2.77575190
14Molar tooth sign on MRI (HP:0002419)2.77575190
15Abnormal delayed hypersensitivity skin test (HP:0002963)2.75027902
16Arthropathy (HP:0003040)2.74674219
17Nephronophthisis (HP:0000090)2.70824639
18Hyperglycinemia (HP:0002154)2.67924209
19True hermaphroditism (HP:0010459)2.66442723
20Methylmalonic acidemia (HP:0002912)2.61269256
21Abnormality of the renal medulla (HP:0100957)2.59840458
22Pancytopenia (HP:0001876)2.56854729
23Volvulus (HP:0002580)2.55384877
24Renal Fanconi syndrome (HP:0001994)2.49210998
25T lymphocytopenia (HP:0005403)2.49069026
26Abnormality of alanine metabolism (HP:0010916)2.48442393
27Hyperalaninemia (HP:0003348)2.48442393
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.48442393
29Type II lissencephaly (HP:0007260)2.47426001
30Premature loss of primary teeth (HP:0006323)2.41461950
31Abnormality of T cell physiology (HP:0011840)2.39519996
32Increased hepatocellular lipid droplets (HP:0006565)2.39409263
33Abnormality of T cells (HP:0002843)2.37306223
34Premature ovarian failure (HP:0008209)2.33065156
35Increased CSF lactate (HP:0002490)2.31274292
36Retrobulbar optic neuritis (HP:0100654)2.31239268
37Optic neuritis (HP:0100653)2.31239268
38Abnormality of eosinophils (HP:0001879)2.31085877
39Hepatic necrosis (HP:0002605)2.28297048
40Thyroiditis (HP:0100646)2.27777976
41Lipid accumulation in hepatocytes (HP:0006561)2.25966099
42Congenital, generalized hypertrichosis (HP:0004540)2.25025641
43Polyuria (HP:0000103)2.24623222
44Abnormality of the ileum (HP:0001549)2.24006852
45Keratoconjunctivitis (HP:0001096)2.20117642
46Large for gestational age (HP:0001520)2.19043102
47Increased corneal curvature (HP:0100692)2.18758505
48Keratoconus (HP:0000563)2.18758505
49Increased serum lactate (HP:0002151)2.14850462
50Polydipsia (HP:0001959)2.14534048
51Abnormal drinking behavior (HP:0030082)2.14534048
52Abnormality of glycine metabolism (HP:0010895)2.14435050
53Abnormality of serine family amino acid metabolism (HP:0010894)2.14435050
54Methylmalonic aciduria (HP:0012120)2.14425447
55Mitochondrial inheritance (HP:0001427)2.13387231
56Meckel diverticulum (HP:0002245)2.12339561
57Chronic hepatic failure (HP:0100626)2.12145767
58Type I transferrin isoform profile (HP:0003642)2.12108228
59Optic disc pallor (HP:0000543)2.11719789
60Chronic diarrhea (HP:0002028)2.08043089
61Progressive inability to walk (HP:0002505)2.07799268
62Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.03877666
63Hepatocellular necrosis (HP:0001404)2.02580518
64Autoimmune hemolytic anemia (HP:0001890)2.00287970
65Abnormality of DNA repair (HP:0003254)1.99829213
66CNS hypomyelination (HP:0003429)1.99714536
67Hypoproteinemia (HP:0003075)1.98857433
68Hyperglycinuria (HP:0003108)1.97048392
69Medial flaring of the eyebrow (HP:0010747)1.96925244
70Bile duct proliferation (HP:0001408)1.96636332
71Abnormal biliary tract physiology (HP:0012439)1.96636332
72Generalized aminoaciduria (HP:0002909)1.96151418
73Decreased electroretinogram (ERG) amplitude (HP:0000654)1.95879085
74Tubulointerstitial fibrosis (HP:0005576)1.94832982
75Carpal bone hypoplasia (HP:0001498)1.94442039
76Pancreatic islet-cell hyperplasia (HP:0004510)1.93107484
77Glycosuria (HP:0003076)1.93105001
78Abnormality of urine glucose concentration (HP:0011016)1.93105001
79Autoimmune thrombocytopenia (HP:0001973)1.92827027
80Tubular atrophy (HP:0000092)1.92520878
81Keratoconjunctivitis sicca (HP:0001097)1.92102440
82Congenital stationary night blindness (HP:0007642)1.91835953
83Eosinophilia (HP:0001880)1.91486324
84Abnormality of serum amino acid levels (HP:0003112)1.89193524
85Abnormal urine output (HP:0012590)1.86351659
86Adrenal hypoplasia (HP:0000835)1.84516552
87Cerebellar dysplasia (HP:0007033)1.82484105
88Reduced antithrombin III activity (HP:0001976)1.81465037
89Aplasia/hypoplasia of the uterus (HP:0008684)1.81219435
90Facial diplegia (HP:0001349)1.81192843
91Severe combined immunodeficiency (HP:0004430)1.79714105
92Decreased central vision (HP:0007663)1.77395263
93Brushfield spots (HP:0001088)1.75375969
94Pulmonary infiltrates (HP:0002113)1.74320353
95Acute necrotizing encephalopathy (HP:0006965)1.74224271
96Lactic acidosis (HP:0003128)1.73030824
97Sclerocornea (HP:0000647)1.71974076
98Abnormality of renal resorption (HP:0011038)1.71876959
99Acute encephalopathy (HP:0006846)1.71765166
100Increased intramyocellular lipid droplets (HP:0012240)1.69265902

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.43016472
2TXK3.24434042
3BCKDK2.98431306
4BCR2.87614744
5TLK12.77995547
6BUB12.68011450
7EIF2AK32.62643052
8MAP4K22.54984298
9NUAK12.48082293
10ZAK2.47990632
11ADRBK22.24962426
12KDR2.14931573
13ACVR1B2.08414939
14MAP3K122.06660340
15BMPR1B1.84194482
16TESK21.78766502
17MST41.78728554
18OXSR11.77351691
19SRPK11.76763096
20VRK21.64052725
21STK391.62667751
22TRIM281.61819267
23PLK41.56153475
24CDK81.48889008
25TAOK31.42824871
26MAP2K61.41936489
27PNCK1.34276310
28GRK11.31871380
29CAMKK21.20131124
30PLK21.19013273
31CSNK1G31.18404628
32EIF2AK21.14909845
33PLK31.12593580
34NEK11.10749625
35GRK61.07253828
36IKBKB1.05985376
37MAP3K141.05469785
38TSSK61.04617152
39ITK1.04028726
40VRK11.04011600
41CSNK1G11.04006782
42MAP3K131.03181055
43CSNK1G21.01387416
44STK161.00764731
45PINK10.97247780
46ERBB30.96194904
47ATR0.94323558
48MKNK20.92449833
49CSNK1A1L0.91583399
50TGFBR20.90947030
51WEE10.86723884
52NEK20.86037251
53INSRR0.83592785
54MAP2K20.83418136
55PLK10.80774783
56TAF10.79253077
57TGFBR10.78813364
58CDK30.72994384
59BRSK20.70265310
60WNK40.69024675
61PBK0.68768692
62PAK30.67591351
63STK30.66764450
64FES0.64529835
65PRKCI0.63505853
66RPS6KA50.62322797
67CHEK20.60853384
68PRKCQ0.59973777
69AURKB0.59537338
70MYLK0.59451229
71AURKA0.58998212
72RPS6KA40.58954687
73ADRBK10.56872829
74NME10.56245498
75DAPK10.53874490
76FER0.53512756
77MKNK10.53325165
78TEC0.53178623
79MAP4K10.51207101
80TIE10.50240196
81TTK0.48849324
82CDK40.48544009
83EPHA30.48186752
84IRAK10.47499004
85WNK30.46821546
86TBK10.46480273
87MAP3K70.46283288
88LIMK10.45521117
89CSNK1A10.44229962
90PIM10.43251811
91CAMK1G0.42195121
92BMPR20.41666358
93NEK90.41378190
94CDK70.40098839
95CDK190.39573350
96CHEK10.38399734
97IKBKE0.37683761
98ATM0.37184957
99FGFR10.33899275
100CSNK1D0.33670742

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.35951691
2Protein export_Homo sapiens_hsa030603.09734336
3Proteasome_Homo sapiens_hsa030503.00472186
4Graft-versus-host disease_Homo sapiens_hsa053322.72865474
5Non-homologous end-joining_Homo sapiens_hsa034502.52309244
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.19958295
7Allograft rejection_Homo sapiens_hsa053302.05988523
8RNA polymerase_Homo sapiens_hsa030202.02521896
9Autoimmune thyroid disease_Homo sapiens_hsa053201.96549842
10Type I diabetes mellitus_Homo sapiens_hsa049401.95513169
11Propanoate metabolism_Homo sapiens_hsa006401.92721461
12Oxidative phosphorylation_Homo sapiens_hsa001901.92037741
13Primary immunodeficiency_Homo sapiens_hsa053401.89899159
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.81433957
15Homologous recombination_Homo sapiens_hsa034401.80394199
16Antigen processing and presentation_Homo sapiens_hsa046121.80236834
17Mismatch repair_Homo sapiens_hsa034301.79292473
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77949646
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73800003
20Fanconi anemia pathway_Homo sapiens_hsa034601.65952876
21Caffeine metabolism_Homo sapiens_hsa002321.65275334
22One carbon pool by folate_Homo sapiens_hsa006701.63442843
23Phototransduction_Homo sapiens_hsa047441.61269719
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59210921
25RNA degradation_Homo sapiens_hsa030181.54641632
26Parkinsons disease_Homo sapiens_hsa050121.48046704
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.46945221
28Selenocompound metabolism_Homo sapiens_hsa004501.45928055
29Sulfur metabolism_Homo sapiens_hsa009201.40216852
30Tryptophan metabolism_Homo sapiens_hsa003801.38734141
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.37378533
32DNA replication_Homo sapiens_hsa030301.36332059
33Basal transcription factors_Homo sapiens_hsa030221.34558175
34Linoleic acid metabolism_Homo sapiens_hsa005911.33502881
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.32191679
36Nitrogen metabolism_Homo sapiens_hsa009101.30054006
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.29869577
38Peroxisome_Homo sapiens_hsa041461.29817578
39Nucleotide excision repair_Homo sapiens_hsa034201.23649541
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.22919299
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.21087497
42Butanoate metabolism_Homo sapiens_hsa006501.15139399
43Purine metabolism_Homo sapiens_hsa002301.14905322
44Fatty acid elongation_Homo sapiens_hsa000621.13885250
45Rheumatoid arthritis_Homo sapiens_hsa053231.13023146
46Pyrimidine metabolism_Homo sapiens_hsa002401.12576693
47RNA transport_Homo sapiens_hsa030131.12342526
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08705375
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06746912
50NF-kappa B signaling pathway_Homo sapiens_hsa040641.05318254
51Huntingtons disease_Homo sapiens_hsa050161.04127415
52Asthma_Homo sapiens_hsa053101.02785383
53Arachidonic acid metabolism_Homo sapiens_hsa005900.99637567
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98928853
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.94697764
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93777135
57Steroid biosynthesis_Homo sapiens_hsa001000.90952613
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86273963
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.86176469
60ABC transporters_Homo sapiens_hsa020100.84829412
61Olfactory transduction_Homo sapiens_hsa047400.83176654
62Alzheimers disease_Homo sapiens_hsa050100.79829939
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78807109
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77119431
65Ether lipid metabolism_Homo sapiens_hsa005650.74786322
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74015370
67Spliceosome_Homo sapiens_hsa030400.72200914
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71054376
69Hematopoietic cell lineage_Homo sapiens_hsa046400.68449524
70Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67850392
71Phenylalanine metabolism_Homo sapiens_hsa003600.62653509
72Retinol metabolism_Homo sapiens_hsa008300.61970264
73Collecting duct acid secretion_Homo sapiens_hsa049660.61502733
74Regulation of autophagy_Homo sapiens_hsa041400.61204037
75p53 signaling pathway_Homo sapiens_hsa041150.58893307
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.58305435
77Metabolic pathways_Homo sapiens_hsa011000.57647440
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56756108
79Systemic lupus erythematosus_Homo sapiens_hsa053220.55801510
80Measles_Homo sapiens_hsa051620.55603599
81Pyruvate metabolism_Homo sapiens_hsa006200.55542956
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54126597
83N-Glycan biosynthesis_Homo sapiens_hsa005100.50317286
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50185194
85Herpes simplex infection_Homo sapiens_hsa051680.47947862
86Chemical carcinogenesis_Homo sapiens_hsa052040.44159292
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43829929
88Epstein-Barr virus infection_Homo sapiens_hsa051690.43607549
89Base excision repair_Homo sapiens_hsa034100.43001243
90Cardiac muscle contraction_Homo sapiens_hsa042600.41428850
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38058745
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38038111
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.35732665
94Oocyte meiosis_Homo sapiens_hsa041140.35676026
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32608946
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.31948392
97Tyrosine metabolism_Homo sapiens_hsa003500.31413443
98Folate biosynthesis_Homo sapiens_hsa007900.30945513
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27471733
100Fat digestion and absorption_Homo sapiens_hsa049750.26121337

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