XRCC6P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine metabolic process (GO:0046087)7.47642322
2cytidine catabolic process (GO:0006216)7.47642322
3cytidine deamination (GO:0009972)7.47642322
4DNA deamination (GO:0045006)7.12000091
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.03195784
6pyrimidine ribonucleoside catabolic process (GO:0046133)6.48188719
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.68373132
8energy coupled proton transport, down electrochemical gradient (GO:0015985)4.29999963
9ATP synthesis coupled proton transport (GO:0015986)4.29999963
10negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.21825383
11proteasome assembly (GO:0043248)4.06702561
12regulation of cellular amino acid metabolic process (GO:0006521)3.94604765
13sequestering of actin monomers (GO:0042989)3.91850635
14DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.88525625
15positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.86558648
16DNA damage response, detection of DNA damage (GO:0042769)3.84463926
17signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.79846728
18signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.79846728
19signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.79846728
20negative regulation of ligase activity (GO:0051352)3.78971627
21negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.78971627
22intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.77064168
23signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.77064168
24protein complex biogenesis (GO:0070271)3.75922635
25regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.73379236
26DNA ligation (GO:0006266)3.72923860
27RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.71648591
28tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.71648591
29mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.69010552
30DNA demethylation (GO:0080111)3.67758155
31positive regulation of defense response to virus by host (GO:0002230)3.66014704
32water-soluble vitamin biosynthetic process (GO:0042364)3.62526080
33DNA double-strand break processing (GO:0000729)3.62399939
34signal transduction involved in DNA damage checkpoint (GO:0072422)3.60217392
35signal transduction involved in DNA integrity checkpoint (GO:0072401)3.60217392
36signal transduction involved in cell cycle checkpoint (GO:0072395)3.56115817
37mitochondrial respiratory chain complex assembly (GO:0033108)3.55832465
38protein polyglutamylation (GO:0018095)3.50308518
39anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.49711564
40respiratory chain complex IV assembly (GO:0008535)3.45550386
41mannosylation (GO:0097502)3.36547530
42iron-sulfur cluster assembly (GO:0016226)3.36088754
43metallo-sulfur cluster assembly (GO:0031163)3.36088754
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.30906840
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.29583093
46mitochondrial respiratory chain complex I assembly (GO:0032981)3.29583093
47NADH dehydrogenase complex assembly (GO:0010257)3.29583093
48DNA catabolic process, exonucleolytic (GO:0000738)3.28484737
49respiratory electron transport chain (GO:0022904)3.23340359
50establishment of protein localization to mitochondrial membrane (GO:0090151)3.23053211
51pseudouridine synthesis (GO:0001522)3.22882120
52positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.20222265
53electron transport chain (GO:0022900)3.20022240
54cytochrome complex assembly (GO:0017004)3.18494252
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.18359877
56response to interferon-beta (GO:0035456)3.17617211
57negative regulation by host of viral transcription (GO:0043922)3.14798758
58Arp2/3 complex-mediated actin nucleation (GO:0034314)3.11739979
59cellular response to interferon-beta (GO:0035458)3.10784189
60pyrimidine nucleoside catabolic process (GO:0046135)3.10011112
61ubiquinone metabolic process (GO:0006743)3.09522326
62exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.06015465
63platelet dense granule organization (GO:0060155)3.03610681
64antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.03099017
65positive regulation of ligase activity (GO:0051351)3.02858756
66regulation of mitochondrial translation (GO:0070129)2.98536341
67protein localization to cilium (GO:0061512)2.96971283
68DNA dealkylation (GO:0035510)2.96574094
69positive regulation of cell cycle arrest (GO:0071158)2.95996012
70negative regulation of nitric-oxide synthase activity (GO:0051001)2.95097940
71protein K6-linked ubiquitination (GO:0085020)2.94814515
72DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.94539200
73ubiquinone biosynthetic process (GO:0006744)2.92576182
74rRNA modification (GO:0000154)2.90425696
75establishment of integrated proviral latency (GO:0075713)2.83522825
76cullin deneddylation (GO:0010388)2.82889857
77negative regulation of telomere maintenance (GO:0032205)2.82570532
78actin nucleation (GO:0045010)2.79195309
79positive regulation of interleukin-8 secretion (GO:2000484)2.76957432
80preassembly of GPI anchor in ER membrane (GO:0016254)2.76920024
81deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.76395904
82regulation of cellular amine metabolic process (GO:0033238)2.76344991
83protein deneddylation (GO:0000338)2.72653996
84regulation of ubiquitin-protein transferase activity (GO:0051438)2.69860883
85maturation of 5.8S rRNA (GO:0000460)2.62761292
86hydrogen ion transmembrane transport (GO:1902600)2.61889320
87protein neddylation (GO:0045116)2.60580426
88piRNA metabolic process (GO:0034587)2.59132020
89detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.58657058
90rRNA catabolic process (GO:0016075)2.58612998
91regulation of ligase activity (GO:0051340)2.57447122
92regulation of cell cycle arrest (GO:0071156)2.54911181
93proton transport (GO:0015992)2.54810442
94cellular response to interleukin-15 (GO:0071350)2.54446414
95GPI anchor metabolic process (GO:0006505)2.53711523
96negative regulation of protein ubiquitination (GO:0031397)2.53632524
97positive regulation of prostaglandin secretion (GO:0032308)2.52968326
98cellular ketone body metabolic process (GO:0046950)2.49101804
99hydrogen transport (GO:0006818)2.48426482
100purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.48313142

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.82354706
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.36752605
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.92089907
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.69405293
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.56025528
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.22237554
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.07238734
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.99786790
9ZNF274_21170338_ChIP-Seq_K562_Hela2.85657266
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.45311665
11VDR_23849224_ChIP-Seq_CD4+_Human2.44553911
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.42400091
13IGF1R_20145208_ChIP-Seq_DFB_Human2.39817666
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.38307268
15VDR_22108803_ChIP-Seq_LS180_Human2.23345227
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.18463851
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.14117407
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.08907953
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.07412268
20FOXP3_21729870_ChIP-Seq_TREG_Human2.06167359
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.96111116
22MYC_18940864_ChIP-ChIP_HL60_Human1.93119045
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.92561181
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.91988840
25ELK1_19687146_ChIP-ChIP_HELA_Human1.85120515
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.76606034
27E2F7_22180533_ChIP-Seq_HELA_Human1.72567389
28IRF1_19129219_ChIP-ChIP_H3396_Human1.70526309
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65280607
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.60481584
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.60414961
32EWS_26573619_Chip-Seq_HEK293_Human1.60236425
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60106879
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55223062
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.52376446
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.49196805
37FOXA1_25329375_ChIP-Seq_VCAP_Human1.47935868
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.47935868
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45010788
40PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.44819625
41TP53_22573176_ChIP-Seq_HFKS_Human1.44454982
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.41089202
43MYC_18555785_ChIP-Seq_MESCs_Mouse1.39770770
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.35657101
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.34042557
46AR_20517297_ChIP-Seq_VCAP_Human1.28003461
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26479023
48GATA3_26560356_Chip-Seq_TH2_Human1.26196327
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26083717
50TAF15_26573619_Chip-Seq_HEK293_Human1.24316080
51STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.23934505
52DCP1A_22483619_ChIP-Seq_HELA_Human1.23624914
53ER_23166858_ChIP-Seq_MCF-7_Human1.23225298
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22850210
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22795003
56HTT_18923047_ChIP-ChIP_STHdh_Human1.22723808
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22646242
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22315758
59GABP_19822575_ChIP-Seq_HepG2_Human1.21968761
60SOX2_19829295_ChIP-Seq_ESCs_Human1.19676363
61NANOG_19829295_ChIP-Seq_ESCs_Human1.19676363
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18772556
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17388867
64LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17158882
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13735513
66MYB_26560356_Chip-Seq_TH2_Human1.13178367
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13119492
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09754716
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07200857
70PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06475246
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05695863
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04530462
73E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02273706
74NCOR_22424771_ChIP-Seq_293T_Human1.01675541
75NANOG_20526341_ChIP-Seq_ESCs_Human1.01406960
76MYC_19030024_ChIP-ChIP_MESCs_Mouse1.01194350
77P300_19829295_ChIP-Seq_ESCs_Human1.00977154
78TTF2_22483619_ChIP-Seq_HELA_Human1.00080658
79AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99891387
80GATA3_21878914_ChIP-Seq_MCF-7_Human0.99713227
81ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99462199
82CIITA_25753668_ChIP-Seq_RAJI_Human0.99250841
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98334387
84CBP_20019798_ChIP-Seq_JUKART_Human0.98334387
85THAP11_20581084_ChIP-Seq_MESCs_Mouse0.96554562
86TAF2_19829295_ChIP-Seq_ESCs_Human0.96439483
87FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95410759
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94768541
89FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.92784034
90ERG_20517297_ChIP-Seq_VCAP_Human0.92103946
91RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.91754575
92FOXH1_21741376_ChIP-Seq_EPCs_Human0.91718147
93IRF8_21731497_ChIP-ChIP_J774_Mouse0.91480908
94FUS_26573619_Chip-Seq_HEK293_Human0.91259664
95BCAT_22108803_ChIP-Seq_LS180_Human0.90737007
96ELK1_22589737_ChIP-Seq_MCF10A_Human0.90619084
97EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89911590
98GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.89279457
99GBX2_23144817_ChIP-Seq_PC3_Human0.89222727
100SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88780849

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.57066228
2MP0003806_abnormal_nucleotide_metabolis3.34534544
3MP0004147_increased_porphyrin_level3.10659550
4MP0003786_premature_aging2.56557134
5MP0003011_delayed_dark_adaptation2.56446307
6MP0002102_abnormal_ear_morphology2.54706448
7MP0005645_abnormal_hypothalamus_physiol2.35688510
8MP0001984_abnormal_olfaction2.28338550
9MP0008058_abnormal_DNA_repair2.15420012
10MP0002736_abnormal_nociception_after2.09535314
11MP0008877_abnormal_DNA_methylation2.02106836
12MP0009785_altered_susceptibility_to2.01873675
13MP0008995_early_reproductive_senescence1.98778977
14MP0005084_abnormal_gallbladder_morpholo1.94193898
15MP0009333_abnormal_splenocyte_physiolog1.92239736
16MP0001968_abnormal_touch/_nociception1.88387318
17MP0006072_abnormal_retinal_apoptosis1.87638058
18MP0001835_abnormal_antigen_presentation1.85395201
19MP0003880_abnormal_central_pattern1.83141860
20MP0003718_maternal_effect1.74683659
21MP0008875_abnormal_xenobiotic_pharmacok1.71152036
22MP0010094_abnormal_chromosome_stability1.70553134
23MP0001529_abnormal_vocalization1.70259928
24MP0005646_abnormal_pituitary_gland1.69619055
25MP0004145_abnormal_muscle_electrophysio1.64955595
26MP0004742_abnormal_vestibular_system1.64223066
27MP0000372_irregular_coat_pigmentation1.63563028
28MP0003195_calcinosis1.61260416
29MP0008872_abnormal_physiological_respon1.58367359
30MP0002277_abnormal_respiratory_mucosa1.57927193
31MP0003763_abnormal_thymus_physiology1.57858123
32MP0006035_abnormal_mitochondrial_morpho1.56681779
33MP0005389_reproductive_system_phenotype1.56557423
34MP0003646_muscle_fatigue1.56088970
35MP0005551_abnormal_eye_electrophysiolog1.54741828
36MP0003283_abnormal_digestive_organ1.52840310
37MP0006276_abnormal_autonomic_nervous1.52422931
38MP0008007_abnormal_cellular_replicative1.47697737
39MP0005083_abnormal_biliary_tract1.47292410
40MP0002148_abnormal_hypersensitivity_rea1.45295522
41MP0001919_abnormal_reproductive_system1.45014863
42MP0005253_abnormal_eye_physiology1.38250574
43MP0002006_tumorigenesis1.37927347
44MP0002653_abnormal_ependyma_morphology1.36256713
45MP0002876_abnormal_thyroid_physiology1.36153185
46MP0002163_abnormal_gland_morphology1.33750603
47MP0002166_altered_tumor_susceptibility1.33392409
48MP0002160_abnormal_reproductive_system1.21259599
49MP0005000_abnormal_immune_tolerance1.20351195
50MP0010386_abnormal_urinary_bladder1.19430707
51MP0003252_abnormal_bile_duct1.17657360
52MP0003866_abnormal_defecation1.17256557
53MP0002822_catalepsy1.12247727
54MP0005410_abnormal_fertilization1.11917092
55MP0006036_abnormal_mitochondrial_physio1.10097289
56MP0002420_abnormal_adaptive_immunity1.09240284
57MP0001764_abnormal_homeostasis1.08884391
58MP0008789_abnormal_olfactory_epithelium1.07622570
59MP0002723_abnormal_immune_serum1.07507282
60MP0009745_abnormal_behavioral_response1.05119666
61MP0000685_abnormal_immune_system1.04971423
62MP0001819_abnormal_immune_cell1.04416709
63MP0001905_abnormal_dopamine_level1.01532877
64MP0001800_abnormal_humoral_immune1.00780447
65MP0002735_abnormal_chemical_nociception1.00269321
66MP0009379_abnormal_foot_pigmentation0.99844752
67MP0004885_abnormal_endolymph0.98021295
68MP0005379_endocrine/exocrine_gland_phen0.96877532
69MP0003693_abnormal_embryo_hatching0.96838566
70MP0002282_abnormal_trachea_morphology0.95525503
71MP0001485_abnormal_pinna_reflex0.95074436
72MP0002272_abnormal_nervous_system0.94299518
73MP0004142_abnormal_muscle_tone0.92945648
74MP0001790_abnormal_immune_system0.90588523
75MP0005387_immune_system_phenotype0.90588523
76MP0000716_abnormal_immune_system0.88908151
77MP0009765_abnormal_xenobiotic_induced0.88202448
78MP0001188_hyperpigmentation0.87634807
79MP0001929_abnormal_gametogenesis0.87591442
80MP0005025_abnormal_response_to0.86944324
81MP0000631_abnormal_neuroendocrine_gland0.86335850
82MP0000689_abnormal_spleen_morphology0.86296846
83MP0002210_abnormal_sex_determination0.84514939
84MP0002398_abnormal_bone_marrow0.84329009
85MP0000703_abnormal_thymus_morphology0.81239515
86MP0006292_abnormal_olfactory_placode0.80662374
87MP0001501_abnormal_sleep_pattern0.80335786
88MP0001119_abnormal_female_reproductive0.79936415
89MP0003787_abnormal_imprinting0.78961417
90MP0005075_abnormal_melanosome_morpholog0.77805704
91MP0009764_decreased_sensitivity_to0.77562913
92MP0002452_abnormal_antigen_presenting0.77386242
93MP0005332_abnormal_amino_acid0.77378717
94MP0003111_abnormal_nucleus_morphology0.76529537
95MP0002837_dystrophic_cardiac_calcinosis0.75133487
96MP0002405_respiratory_system_inflammati0.73455296
97MP0002722_abnormal_immune_system0.72621630
98MP0002234_abnormal_pharynx_morphology0.70601139
99MP0005636_abnormal_mineral_homeostasis0.70239209
100MP0002095_abnormal_skin_pigmentation0.68664245

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)4.40942727
2Aplastic anemia (HP:0001915)4.40273938
3Renal Fanconi syndrome (HP:0001994)4.15572082
4Lipid accumulation in hepatocytes (HP:0006561)4.13464449
5Mitochondrial inheritance (HP:0001427)4.08538530
6Acute necrotizing encephalopathy (HP:0006965)3.95752864
7Increased intramyocellular lipid droplets (HP:0012240)3.94815436
8Increased CSF lactate (HP:0002490)3.85945278
9Abnormal mitochondria in muscle tissue (HP:0008316)3.72196335
10Methylmalonic acidemia (HP:0002912)3.50666531
11Hepatocellular necrosis (HP:0001404)3.43971117
12Abnormality of alanine metabolism (HP:0010916)3.39502204
13Hyperalaninemia (HP:0003348)3.39502204
14Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.39502204
15Progressive macrocephaly (HP:0004481)3.30496675
16Increased muscle lipid content (HP:0009058)3.29759365
17Elevated erythrocyte sedimentation rate (HP:0003565)3.29128396
18Acute encephalopathy (HP:0006846)3.25264407
19Hepatic necrosis (HP:0002605)3.23786604
20Increased serum lactate (HP:0002151)3.18846773
21Severe combined immunodeficiency (HP:0004430)3.18846767
223-Methylglutaconic aciduria (HP:0003535)3.15740051
23Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.13448614
24Decreased activity of mitochondrial respiratory chain (HP:0008972)3.13448614
25Pancreatic cysts (HP:0001737)3.13052839
26Methylmalonic aciduria (HP:0012120)2.94855467
27IgG deficiency (HP:0004315)2.91680157
28Pancytopenia (HP:0001876)2.89092298
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.83527242
30T lymphocytopenia (HP:0005403)2.81516559
31Abnormality of T cell number (HP:0011839)2.76011567
32Cerebral edema (HP:0002181)2.75304504
33Exertional dyspnea (HP:0002875)2.74099691
34True hermaphroditism (HP:0010459)2.72074219
35Lactic acidosis (HP:0003128)2.71546346
36Combined immunodeficiency (HP:0005387)2.52154993
37Pancreatic fibrosis (HP:0100732)2.50985146
38Attenuation of retinal blood vessels (HP:0007843)2.49109253
39Type II lissencephaly (HP:0007260)2.48953314
40Optic disc pallor (HP:0000543)2.48471018
41Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.46773803
42Hypoproteinemia (HP:0003075)2.46429574
43Colon cancer (HP:0003003)2.40257521
44Thyroiditis (HP:0100646)2.37197065
45Abnormality of renal resorption (HP:0011038)2.37003707
46Abnormality of the renal cortex (HP:0011035)2.34066350
47Abnormality of urine glucose concentration (HP:0011016)2.33688538
48Glycosuria (HP:0003076)2.33688538
49Nephronophthisis (HP:0000090)2.33287883
50Stomatitis (HP:0010280)2.32812406
51Oral leukoplakia (HP:0002745)2.32345143
52Lethargy (HP:0001254)2.31671962
53Autoimmune hemolytic anemia (HP:0001890)2.28772651
54Abolished electroretinogram (ERG) (HP:0000550)2.25059098
55Molar tooth sign on MRI (HP:0002419)2.24800503
56Abnormality of midbrain morphology (HP:0002418)2.24800503
57Renal cortical cysts (HP:0000803)2.23182809
58Retinal dysplasia (HP:0007973)2.22445057
59Abnormality of dicarboxylic acid metabolism (HP:0010995)2.20347811
60Dicarboxylic aciduria (HP:0003215)2.20347811
61Medial flaring of the eyebrow (HP:0010747)2.18187922
62Abnormality of the vitamin B12 metabolism (HP:0004341)2.11797421
63Abnormality of B cell number (HP:0010975)2.11681601
64Abnormality of T cells (HP:0002843)2.06298263
65Hyperphosphaturia (HP:0003109)2.05137454
66Abnormality of the prostate (HP:0008775)2.05060883
67Exercise intolerance (HP:0003546)2.04912295
68Decreased electroretinogram (ERG) amplitude (HP:0000654)2.03503027
69Type I transferrin isoform profile (HP:0003642)2.03424862
70Abnormality of vitamin B metabolism (HP:0004340)2.02651767
71Respiratory failure (HP:0002878)1.99960255
72Ketosis (HP:0001946)1.97245897
73Abnormality of eosinophils (HP:0001879)1.96019431
74Congenital stationary night blindness (HP:0007642)1.95292005
75Cerebellar dysplasia (HP:0007033)1.94568464
76Abnormality of the renal medulla (HP:0100957)1.93927287
77Abnormal albumin level (HP:0012116)1.87479639
78Hypoalbuminemia (HP:0003073)1.87479639
79Hyperglycinuria (HP:0003108)1.85439961
80Ketoacidosis (HP:0001993)1.84720488
81Respiratory difficulties (HP:0002880)1.83971771
82Absent rod-and cone-mediated responses on ERG (HP:0007688)1.83151078
83CNS demyelination (HP:0007305)1.82581603
84B lymphocytopenia (HP:0010976)1.82493949
85Decreased central vision (HP:0007663)1.80514923
86Abnormality of glycine metabolism (HP:0010895)1.79285870
87Abnormality of serine family amino acid metabolism (HP:0010894)1.79285870
88Abnormality of serum amino acid levels (HP:0003112)1.78617425
89Pendular nystagmus (HP:0012043)1.78134686
90Congenital sensorineural hearing impairment (HP:0008527)1.77149671
91Hypothermia (HP:0002045)1.72749131
92Abnormal number of erythroid precursors (HP:0012131)1.71359267
93Progressive microcephaly (HP:0000253)1.70896112
94Leukodystrophy (HP:0002415)1.70788133
95Encephalitis (HP:0002383)1.70182719
96Generalized aminoaciduria (HP:0002909)1.69096980
97Hyperglycinemia (HP:0002154)1.68658411
98Palpitations (HP:0001962)1.68226182
99Abnormal drinking behavior (HP:0030082)1.67210648
100Polydipsia (HP:0001959)1.67210648

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.66867836
2TXK3.64373638
3BUB13.51068094
4KDR3.45967151
5TESK23.45115132
6VRK23.26582371
7ADRBK22.65938674
8ZAK2.60665321
9TAOK32.19452865
10NUAK12.18590362
11GRK12.02322432
12TLK11.94261526
13MAP4K21.88821753
14VRK11.83121261
15MUSK1.82620437
16SRPK11.77910874
17TSSK61.75719680
18WNK31.75023504
19PBK1.53619085
20PLK41.52617956
21NEK11.44062731
22BMPR1B1.42763128
23WEE11.40252577
24MST41.37991741
25DYRK21.37715688
26CDC71.29838961
27PINK11.28767292
28STK161.22975718
29ITK1.20005902
30MAP2K71.18548702
31TRIM281.15991525
32FRK1.14946149
33SCYL21.12843808
34PASK1.10049324
35WNK41.06568069
36EIF2AK30.99593280
37MAP4K10.95769076
38PRKCQ0.95733663
39MAPKAPK50.95634333
40ATR0.93865227
41PLK30.93809757
42PIM20.93218176
43CDK80.91459918
44INSRR0.90414628
45TIE10.84441621
46TEC0.81621425
47TAF10.80239624
48RPS6KA50.79698772
49CSNK1G30.78353811
50FES0.76906161
51LIMK10.76546668
52KIT0.75029182
53MAPK130.74895753
54CSNK1G20.72746246
55MAP2K60.71817616
56IKBKB0.71533962
57ACVR1B0.71375692
58MAP3K40.67332298
59SYK0.66748993
60BCR0.66617899
61AURKA0.66428860
62TESK10.65535626
63OBSCN0.64516248
64CSNK1G10.63351617
65DAPK10.63049540
66MKNK10.55731714
67AURKB0.55156698
68FLT30.52249150
69GRK70.52217016
70ADRBK10.51985051
71TNIK0.50796300
72PRKCG0.50574150
73PLK10.50536423
74MINK10.47811894
75TTK0.45769211
76STK390.45753660
77BRSK20.45233420
78OXSR10.44704998
79LCK0.42177907
80EIF2AK20.42011288
81CSNK1A1L0.41726638
82MAP3K120.40847546
83PLK20.40444281
84CSNK2A10.40312702
85GRK50.39566526
86LYN0.38294026
87PDK20.35896658
88PRKCI0.35168609
89IGF1R0.35157018
90TGFBR10.34407506
91PRKCA0.33168077
92MYLK0.32470262
93IKBKE0.31638565
94CSNK2A20.31006433
95GRK60.30208994
96PIK3CG0.30161118
97PRKACA0.29606339
98CAMK2A0.28975834
99BTK0.28211355
100DAPK20.27971839

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.09244132
2Oxidative phosphorylation_Homo sapiens_hsa001903.45329891
3Primary immunodeficiency_Homo sapiens_hsa053403.00315991
4Parkinsons disease_Homo sapiens_hsa050122.95457508
5Protein export_Homo sapiens_hsa030602.84825923
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.44617971
7RNA polymerase_Homo sapiens_hsa030202.22171211
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.04781140
9Antigen processing and presentation_Homo sapiens_hsa046122.01596909
10Ribosome_Homo sapiens_hsa030102.00855452
11Non-homologous end-joining_Homo sapiens_hsa034501.89945670
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87710691
13Alzheimers disease_Homo sapiens_hsa050101.85501755
14Graft-versus-host disease_Homo sapiens_hsa053321.85493608
15Phototransduction_Homo sapiens_hsa047441.85076190
16DNA replication_Homo sapiens_hsa030301.82733508
17Huntingtons disease_Homo sapiens_hsa050161.78796430
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.78534982
19One carbon pool by folate_Homo sapiens_hsa006701.64258986
20Mismatch repair_Homo sapiens_hsa034301.61638821
21Fanconi anemia pathway_Homo sapiens_hsa034601.60198333
22Homologous recombination_Homo sapiens_hsa034401.57356488
23Autoimmune thyroid disease_Homo sapiens_hsa053201.56730432
24Allograft rejection_Homo sapiens_hsa053301.43304774
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.42901543
26RNA degradation_Homo sapiens_hsa030181.38062099
27Type I diabetes mellitus_Homo sapiens_hsa049401.34883212
28Propanoate metabolism_Homo sapiens_hsa006401.34299504
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32414914
30Pyrimidine metabolism_Homo sapiens_hsa002401.28802354
31Spliceosome_Homo sapiens_hsa030401.28270170
32Peroxisome_Homo sapiens_hsa041461.25230809
33Linoleic acid metabolism_Homo sapiens_hsa005911.24066106
34Nitrogen metabolism_Homo sapiens_hsa009101.21248479
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18337730
36Butanoate metabolism_Homo sapiens_hsa006501.17757499
37Cardiac muscle contraction_Homo sapiens_hsa042601.14344236
38Basal transcription factors_Homo sapiens_hsa030221.14326827
39Nucleotide excision repair_Homo sapiens_hsa034201.12899127
40Hematopoietic cell lineage_Homo sapiens_hsa046401.06925601
41Fatty acid elongation_Homo sapiens_hsa000621.00256568
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99878677
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99070056
44RNA transport_Homo sapiens_hsa030130.95828473
45Purine metabolism_Homo sapiens_hsa002300.94627353
46Sulfur metabolism_Homo sapiens_hsa009200.93462110
47Asthma_Homo sapiens_hsa053100.92938199
48Base excision repair_Homo sapiens_hsa034100.91736097
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91704351
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.89457746
51Rheumatoid arthritis_Homo sapiens_hsa053230.89181162
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85411374
53Tryptophan metabolism_Homo sapiens_hsa003800.81416685
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79376126
55Caffeine metabolism_Homo sapiens_hsa002320.78073680
56Nicotine addiction_Homo sapiens_hsa050330.77719100
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75171831
58Retinol metabolism_Homo sapiens_hsa008300.73966117
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.69093654
60Metabolic pathways_Homo sapiens_hsa011000.68562749
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67704705
62Selenocompound metabolism_Homo sapiens_hsa004500.67042120
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64270670
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.63446874
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.62547157
66Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61765733
67Systemic lupus erythematosus_Homo sapiens_hsa053220.60053790
68Ether lipid metabolism_Homo sapiens_hsa005650.59226011
69Olfactory transduction_Homo sapiens_hsa047400.58866161
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58189532
71Collecting duct acid secretion_Homo sapiens_hsa049660.58059764
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57256536
73Chemical carcinogenesis_Homo sapiens_hsa052040.56598789
74Arachidonic acid metabolism_Homo sapiens_hsa005900.54105918
75N-Glycan biosynthesis_Homo sapiens_hsa005100.53616625
76Steroid biosynthesis_Homo sapiens_hsa001000.53275277
77Regulation of autophagy_Homo sapiens_hsa041400.52684143
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50081598
79Folate biosynthesis_Homo sapiens_hsa007900.49044677
80T cell receptor signaling pathway_Homo sapiens_hsa046600.48552994
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47206547
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45826075
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45352978
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.45078369
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45013896
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44759172
87Vitamin digestion and absorption_Homo sapiens_hsa049770.44758645
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42712965
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41725824
90beta-Alanine metabolism_Homo sapiens_hsa004100.40934413
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.40479767
92Taste transduction_Homo sapiens_hsa047420.40098002
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40050265
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36334813
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36300341
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36114865
97Pyruvate metabolism_Homo sapiens_hsa006200.33614328
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32161465
99Legionellosis_Homo sapiens_hsa051340.31613626
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31130692

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