ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of interleukin-12 biosynthetic process (GO:0045075)	6.94801494
2	positive regulation of prostaglandin secretion (GO:0032308)	5.64348692
3	DNA deamination (GO:0045006)	5.22044905
4	interleukin-1-mediated signaling pathway (GO:0070498)	4.94061139
5	water-soluble vitamin biosynthetic process (GO:0042364)	4.84964103
6	protein polyglutamylation (GO:0018095)	4.81809445
7	regulation of prostaglandin secretion (GO:0032306)	4.75731712
8	maturation of 5.8S rRNA (GO:0000460)	4.43409215
9	positive regulation of T cell cytokine production (GO:0002726)	4.37126396
10	positive regulation of osteoclast differentiation (GO:0045672)	4.29900486
11	positive regulation of heat generation (GO:0031652)	4.24868950
12	hyperosmotic salinity response (GO:0042538)	4.16482682
13	regulation of interleukin-6 biosynthetic process (GO:0045408)	4.02038425
14	regulation of immunoglobulin secretion (GO:0051023)	3.98067241
15	positive regulation of immune response to tumor cell (GO:0002839)	3.96027252
16	regulation of immune response to tumor cell (GO:0002837)	3.96027252
17	regulation of response to tumor cell (GO:0002834)	3.96027252
18	positive regulation of response to tumor cell (GO:0002836)	3.96027252
19	positive regulation of icosanoid secretion (GO:0032305)	3.94366735
20	positive regulation of fatty acid transport (GO:2000193)	3.88109152
21	sulfation (GO:0051923)	3.86252348
22	DNA ligation (GO:0006266)	3.84673363
23	activated T cell proliferation (GO:0050798)	3.81772457
24	protein-cofactor linkage (GO:0018065)	3.76541799
25	regulation of fever generation (GO:0031620)	3.73146316
26	establishment of integrated proviral latency (GO:0075713)	3.67904559
27	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	3.67737681
28	positive regulation of transcription regulatory region DNA binding (GO:2000679)	3.55385860
29	branched-chain amino acid catabolic process (GO:0009083)	3.55210361
30	L-fucose catabolic process (GO:0042355)	3.54042704
31	fucose catabolic process (GO:0019317)	3.54042704
32	L-fucose metabolic process (GO:0042354)	3.54042704
33	regulation of heat generation (GO:0031650)	3.53575464
34	respiratory chain complex IV assembly (GO:0008535)	3.48432426
35	regulation of cilium movement (GO:0003352)	3.47439695
36	pseudouridine synthesis (GO:0001522)	3.43270164
37	actin nucleation (GO:0045010)	3.42887578
38	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.40579805
39	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.35293190
40	protein complex biogenesis (GO:0070271)	3.28924971
41	mannosylation (GO:0097502)	3.24639176
42	cellular ketone body metabolic process (GO:0046950)	3.23422895
43	cullin deneddylation (GO:0010388)	3.22987456
44	cellular hyperosmotic response (GO:0071474)	3.21240977
45	termination of RNA polymerase III transcription (GO:0006386)	3.18834591
46	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.18834591
47	cytidine deamination (GO:0009972)	3.16913668
48	cytidine metabolic process (GO:0046087)	3.16913668
49	cytidine catabolic process (GO:0006216)	3.16913668
50	S-adenosylmethionine metabolic process (GO:0046500)	3.15562174
51	regulation of mitotic spindle checkpoint (GO:1903504)	3.13751138
52	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.13751138
53	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.08884439
54	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.06564583
55	NADH dehydrogenase complex assembly (GO:0010257)	3.06564583
56	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.06564583
57	regulation of T cell cytokine production (GO:0002724)	3.04797447
58	branched-chain amino acid metabolic process (GO:0009081)	3.04536653
59	cytochrome complex assembly (GO:0017004)	3.02048297
60	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.01957616
61	protein deneddylation (GO:0000338)	2.99838423
62	kynurenine metabolic process (GO:0070189)	2.96831302
63	preassembly of GPI anchor in ER membrane (GO:0016254)	2.96312016
64	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.93727009
65	regulation of icosanoid secretion (GO:0032303)	2.93248905
66	signal peptide processing (GO:0006465)	2.92622682
67	DNA replication checkpoint (GO:0000076)	2.92075231
68	establishment of viral latency (GO:0019043)	2.90021816
69	regulation of isotype switching to IgG isotypes (GO:0048302)	2.89673634
70	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.87426832
71	prenylation (GO:0097354)	2.87343638
72	protein prenylation (GO:0018342)	2.87343638
73	DNA catabolic process, exonucleolytic (GO:0000738)	2.86565618
74	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.86486947
75	mitochondrial respiratory chain complex assembly (GO:0033108)	2.86083139
76	rRNA catabolic process (GO:0016075)	2.84859505
77	DNA double-strand break processing (GO:0000729)	2.84104022
78	ketone body metabolic process (GO:1902224)	2.83727159
79	negative regulation of metanephros development (GO:0072217)	2.83552675
80	positive regulation of interleukin-12 production (GO:0032735)	2.78697768
81	rhodopsin mediated signaling pathway (GO:0016056)	2.78614683
82	negative regulation of meiotic cell cycle (GO:0051447)	2.77012154
83	piRNA metabolic process (GO:0034587)	2.75881721
84	L-methionine salvage (GO:0071267)	2.75607590
85	L-methionine biosynthetic process (GO:0071265)	2.75607590
86	amino acid salvage (GO:0043102)	2.75607590
87	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.74996609
88	cellular response to interleukin-15 (GO:0071350)	2.74963111
89	peptidyl-histidine modification (GO:0018202)	2.72988744
90	vitamin biosynthetic process (GO:0009110)	2.72799876
91	short-chain fatty acid metabolic process (GO:0046459)	2.72686016
92	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.71355506
93	tRNA processing (GO:0008033)	2.68907848
94	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.61325969
95	positive regulation of defense response to virus by host (GO:0002230)	2.60118947
96	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.56597991
97	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.56597991
98	isotype switching (GO:0045190)	2.56597991
99	behavioral response to nicotine (GO:0035095)	2.56450097
100	somatic diversification of immune receptors (GO:0002200)	2.55275055

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.38861862
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.82313845
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.32895142
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.30606835
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.27461115
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.20291694
7	VDR_22108803_ChIP-Seq_LS180_Human	2.75685257
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.70914024
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.53734516
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.52321500
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.45672378
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.43606259
13	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.43181001
14	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.39866420
15	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.33631889
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.32616838
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.25323656
18	EWS_26573619_Chip-Seq_HEK293_Human	2.12734374
19	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.08896303
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.98297145
21	FOXP3_21729870_ChIP-Seq_TREG_Human	1.97141024
22	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.90738404
23	MYC_18940864_ChIP-ChIP_HL60_Human	1.85479290
24	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.77981644
25	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.76130428
26	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.71937378
27	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.71704047
28	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.69017307
29	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.67781204
30	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.62550448
31	FUS_26573619_Chip-Seq_HEK293_Human	1.59420351
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.58769455
33	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.58400710
34	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.56936739
35	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.51984040
36	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.51955070
37	ELK1_19687146_ChIP-ChIP_HELA_Human	1.47863820
38	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.45525853
39	AR_20517297_ChIP-Seq_VCAP_Human	1.45510071
40	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.45464329
41	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.45310989
42	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.44115528
43	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.42694439
44	GATA3_26560356_Chip-Seq_TH2_Human	1.42501080
45	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.40628237
46	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.40628237
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.40143542
48	HTT_18923047_ChIP-ChIP_STHdh_Human	1.38717976
49	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.38303366
50	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.36421399
51	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.35499710
52	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.32785339
53	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.30862309
54	GBX2_23144817_ChIP-Seq_PC3_Human	1.28532217
55	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.26186015
56	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.25532872
57	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.21414115
58	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.21382594
59	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.18214320
60	ER_23166858_ChIP-Seq_MCF-7_Human	1.17987558
61	DCP1A_22483619_ChIP-Seq_HELA_Human	1.16503199
62	CBP_20019798_ChIP-Seq_JUKART_Human	1.15429091
63	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.15429091
64	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.14064601
65	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.13939741
66	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.12509010
67	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.11778244
68	IRF1_19129219_ChIP-ChIP_H3396_Human	1.09083648
69	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.07451542
70	SOX2_19829295_ChIP-Seq_ESCs_Human	1.07397207
71	NANOG_19829295_ChIP-Seq_ESCs_Human	1.07397207
72	P300_19829295_ChIP-Seq_ESCs_Human	1.06495082
73	GABP_19822575_ChIP-Seq_HepG2_Human	1.02651829
74	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00818735
75	TAF15_26573619_Chip-Seq_HEK293_Human	0.99094609
76	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.98312158
77	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.98112201
78	MYC_19829295_ChIP-Seq_ESCs_Human	0.97866664
79	HOXB7_26014856_ChIP-Seq_BT474_Human	0.97059103
80	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.96330794
81	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.95628098
82	CDX2_22108803_ChIP-Seq_LS180_Human	0.95236731
83	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.93546869
84	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.93292565
85	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.93120576
86	KDM5A_27292631_Chip-Seq_BREAST_Human	0.92793637
87	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.92496482
88	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.91038282
89	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.90760536
90	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.90422249
91	NCOR_22424771_ChIP-Seq_293T_Human	0.86933791
92	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.86720392
93	TCF4_22108803_ChIP-Seq_LS180_Human	0.86330197
94	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.86140809
95	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.86119769
96	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.86029525
97	BCAT_22108803_ChIP-Seq_LS180_Human	0.85755128
98	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.85506610
99	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.83762848
100	PHF8_20622853_ChIP-Seq_HELA_Human	0.83747904

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.15999445
2	MP0003195_calcinosis	3.13805665
3	MP0002876_abnormal_thyroid_physiology	2.86481817
4	MP0004782_abnormal_surfactant_physiolog	2.84956922
5	MP0000685_abnormal_immune_system	2.84422543
6	MP0003693_abnormal_embryo_hatching	2.56024018
7	MP0002148_abnormal_hypersensitivity_rea	2.52574357
8	MP0009333_abnormal_splenocyte_physiolog	2.49851517
9	MP0003436_decreased_susceptibility_to	2.12954104
10	MP0001984_abnormal_olfaction	2.12946286
11	MP0002102_abnormal_ear_morphology	2.11304249
12	MP0002163_abnormal_gland_morphology	2.09852487
13	MP0002277_abnormal_respiratory_mucosa	2.07730562
14	MP0001968_abnormal_touch/_nociception	1.98776497
15	MP0004885_abnormal_endolymph	1.95731486
16	MP0000372_irregular_coat_pigmentation	1.94025264
17	MP0001835_abnormal_antigen_presentation	1.90531959
18	MP0001986_abnormal_taste_sensitivity	1.82319640
19	MP0009840_abnormal_foam_cell	1.81548930
20	MP0005551_abnormal_eye_electrophysiolog	1.79772771
21	MP0008875_abnormal_xenobiotic_pharmacok	1.78953628
22	MP0003718_maternal_effect	1.76506986
23	MP0001873_stomach_inflammation	1.72538004
24	MP0006072_abnormal_retinal_apoptosis	1.70118250
25	MP0003787_abnormal_imprinting	1.67978211
26	MP0002138_abnormal_hepatobiliary_system	1.66417137
27	MP0002405_respiratory_system_inflammati	1.66115100
28	MP0008872_abnormal_physiological_respon	1.65977284
29	MP0005379_endocrine/exocrine_gland_phen	1.65094827
30	MP0000383_abnormal_hair_follicle	1.63684889
31	MP0003724_increased_susceptibility_to	1.58919152
32	MP0005387_immune_system_phenotype	1.57794372
33	MP0001790_abnormal_immune_system	1.57794372
34	MP0003806_abnormal_nucleotide_metabolis	1.56747016
35	MP0005187_abnormal_penis_morphology	1.55540803
36	MP0008877_abnormal_DNA_methylation	1.55190235
37	MP0002736_abnormal_nociception_after	1.54275603
38	MP0002837_dystrophic_cardiac_calcinosis	1.52422394
39	MP0001800_abnormal_humoral_immune	1.46871792
40	MP0005000_abnormal_immune_tolerance	1.45658237
41	MP0006035_abnormal_mitochondrial_morpho	1.44953770
42	MP0000569_abnormal_digit_pigmentation	1.44017805
43	MP0008007_abnormal_cellular_replicative	1.42200702
44	MP0008789_abnormal_olfactory_epithelium	1.40056769
45	MP0002095_abnormal_skin_pigmentation	1.38717904
46	MP0009785_altered_susceptibility_to	1.35494722
47	MP0002723_abnormal_immune_serum	1.34964685
48	MP0008058_abnormal_DNA_repair	1.32201964
49	MP0010094_abnormal_chromosome_stability	1.29401164
50	MP0000538_abnormal_urinary_bladder	1.28483091
51	MP0001764_abnormal_homeostasis	1.26703953
52	MP0009765_abnormal_xenobiotic_induced	1.21338758
53	MP0001881_abnormal_mammary_gland	1.20698781
54	MP0009780_abnormal_chondrocyte_physiolo	1.19467787
55	MP0005253_abnormal_eye_physiology	1.18709020
56	MP0000427_abnormal_hair_cycle	1.17499087
57	MP0003786_premature_aging	1.16331998
58	MP0010386_abnormal_urinary_bladder	1.14340569
59	MP0005646_abnormal_pituitary_gland	1.10497110
60	MP0008775_abnormal_heart_ventricle	1.08365508
61	MP0003646_muscle_fatigue	1.08218710
62	MP0002420_abnormal_adaptive_immunity	1.05542304
63	MP0005332_abnormal_amino_acid	1.05287678
64	MP0006292_abnormal_olfactory_placode	1.03913600
65	MP0001819_abnormal_immune_cell	1.02614320
66	MP0001533_abnormal_skeleton_physiology	1.02552759
67	MP0002452_abnormal_antigen_presenting	1.01909083
68	MP0000689_abnormal_spleen_morphology	1.01712699
69	MP0005410_abnormal_fertilization	0.99665730
70	MP0009046_muscle_twitch	0.99210004
71	MP0009764_decreased_sensitivity_to	0.98641274
72	MP0004142_abnormal_muscle_tone	0.98279423
73	MP0004145_abnormal_muscle_electrophysio	0.96817250
74	MP0005636_abnormal_mineral_homeostasis	0.96679528
75	MP0000647_abnormal_sebaceous_gland	0.93965354
76	MP0005645_abnormal_hypothalamus_physiol	0.91491548
77	MP0001845_abnormal_inflammatory_respons	0.87131250
78	MP0005167_abnormal_blood-brain_barrier	0.85524795
79	MP0003186_abnormal_redox_activity	0.83734491
80	MP0005084_abnormal_gallbladder_morpholo	0.83202287
81	MP0001529_abnormal_vocalization	0.82844577
82	MP0001501_abnormal_sleep_pattern	0.82070107
83	MP0002722_abnormal_immune_system	0.81172422
84	MP0006036_abnormal_mitochondrial_physio	0.80935888
85	MP0005448_abnormal_energy_balance	0.80025564
86	MP0002272_abnormal_nervous_system	0.79417769
87	MP0002398_abnormal_bone_marrow	0.79053575
88	MP0000639_abnormal_adrenal_gland	0.78165527
89	MP0004742_abnormal_vestibular_system	0.77691522
90	MP0005075_abnormal_melanosome_morpholog	0.76932117
91	MP0001765_abnormal_ion_homeostasis	0.76813875
92	MP0002693_abnormal_pancreas_physiology	0.76706270
93	MP0002234_abnormal_pharynx_morphology	0.76187175
94	MP0002139_abnormal_hepatobiliary_system	0.75178044
95	MP0001929_abnormal_gametogenesis	0.75155887
96	MP0010155_abnormal_intestine_physiology	0.74662872
97	MP0002229_neurodegeneration	0.74357921
98	MP0006082_CNS_inflammation	0.73371957
99	MP0005174_abnormal_tail_pigmentation	0.71831503
100	MP0004147_increased_porphyrin_level	0.71828682

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the renal cortex (HP:0011035)	3.71476137
2	3-Methylglutaconic aciduria (HP:0003535)	3.59778090
3	Attenuation of retinal blood vessels (HP:0007843)	3.55899027
4	Premature loss of primary teeth (HP:0006323)	3.54726794
5	Decreased central vision (HP:0007663)	3.52047841
6	Autoimmune hemolytic anemia (HP:0001890)	3.19486955
7	IgG deficiency (HP:0004315)	3.16717482
8	Renal cortical cysts (HP:0000803)	3.13363552
9	Abnormality of the renal medulla (HP:0100957)	3.08217908
10	Abnormality of alanine metabolism (HP:0010916)	2.99817214
11	Hyperalaninemia (HP:0003348)	2.99817214
12	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.99817214
13	Methylmalonic acidemia (HP:0002912)	2.96578912
14	Pancytopenia (HP:0001876)	2.94822953
15	Nephronophthisis (HP:0000090)	2.94364072
16	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.91690677
17	Congenital stationary night blindness (HP:0007642)	2.89883612
18	Pancreatic cysts (HP:0001737)	2.83386762
19	Autoimmune thrombocytopenia (HP:0001973)	2.82337465
20	Increased CSF lactate (HP:0002490)	2.81219731
21	Abnormality of T cell number (HP:0011839)	2.76461673
22	Increased IgM level (HP:0003496)	2.75920652
23	Hypoproteinemia (HP:0003075)	2.74015378
24	Chronic diarrhea (HP:0002028)	2.73236481
25	Increased serum lactate (HP:0002151)	2.68836474
26	Colon cancer (HP:0003003)	2.62481741
27	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.60811298
28	Increased density of long bones (HP:0006392)	2.57031144
29	Hepatic necrosis (HP:0002605)	2.56461539
30	Hypoplasia of the uterus (HP:0000013)	2.53463152
31	Abnormality of T cell physiology (HP:0011840)	2.53238355
32	Mitochondrial inheritance (HP:0001427)	2.49427246
33	Increased hepatocellular lipid droplets (HP:0006565)	2.48643969
34	Hyperglycinemia (HP:0002154)	2.48261548
35	Acute necrotizing encephalopathy (HP:0006965)	2.46426634
36	Abnormality of midbrain morphology (HP:0002418)	2.45881884
37	Molar tooth sign on MRI (HP:0002419)	2.45881884
38	Large for gestational age (HP:0001520)	2.45180553
39	Hepatocellular necrosis (HP:0001404)	2.42739749
40	Metabolic alkalosis (HP:0200114)	2.36726709
41	Type II lissencephaly (HP:0007260)	2.35060248
42	Abnormality of polysaccharide metabolism (HP:0011012)	2.34588149
43	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.34588149
44	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.34588149
45	Stomatitis (HP:0010280)	2.34273759
46	Abnormality of T cells (HP:0002843)	2.33632395
47	Methylmalonic aciduria (HP:0012120)	2.33093810
48	Abnormality of serum amino acid levels (HP:0003112)	2.32389405
49	Pancreatic fibrosis (HP:0100732)	2.30268354
50	Lipid accumulation in hepatocytes (HP:0006561)	2.26986195
51	Abnormal rod and cone electroretinograms (HP:0008323)	2.22929249
52	Aplasia/hypoplasia of the uterus (HP:0008684)	2.22424403
53	Spontaneous abortion (HP:0005268)	2.21915615
54	Urinary glycosaminoglycan excretion (HP:0003541)	2.18855301
55	Mucopolysacchariduria (HP:0008155)	2.18855301
56	Stomach cancer (HP:0012126)	2.17759010
57	Abolished electroretinogram (ERG) (HP:0000550)	2.16851308
58	Abnormal mitochondria in muscle tissue (HP:0008316)	2.16482291
59	Cerebral edema (HP:0002181)	2.14765125
60	Increased corneal curvature (HP:0100692)	2.14147389
61	Keratoconus (HP:0000563)	2.14147389
62	Hypokalemic alkalosis (HP:0001949)	2.13777520
63	Acute encephalopathy (HP:0006846)	2.13296262
64	Lactic acidosis (HP:0003128)	2.12484971
65	Progressive macrocephaly (HP:0004481)	2.09296971
66	CNS hypomyelination (HP:0003429)	2.08398881
67	Asymmetric septal hypertrophy (HP:0001670)	2.07505497
68	Polyuria (HP:0000103)	2.07163164
69	Abnormality of eosinophils (HP:0001879)	2.05926677
70	Optic disc pallor (HP:0000543)	2.05590176
71	Beaking of vertebral bodies (HP:0004568)	2.04597054
72	Persistence of primary teeth (HP:0006335)	2.02617399
73	Nausea (HP:0002018)	2.01352863
74	Chronic hepatic failure (HP:0100626)	1.95770567
75	Tubular atrophy (HP:0000092)	1.91590107
76	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.91215285
77	Hyperglycemia (HP:0003074)	1.88922400
78	Ketosis (HP:0001946)	1.88554087
79	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.88489199
80	T lymphocytopenia (HP:0005403)	1.88106623
81	Severe combined immunodeficiency (HP:0004430)	1.87929516
82	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.86155405
83	Ependymoma (HP:0002888)	1.85483011
84	Retinal dysplasia (HP:0007973)	1.84979848
85	Sensorimotor neuropathy (HP:0007141)	1.84772121
86	Pulmonary infiltrates (HP:0002113)	1.84613835
87	Abnormality of vitamin B metabolism (HP:0004340)	1.83702830
88	Poor head control (HP:0002421)	1.83529085
89	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.82704795
90	Lissencephaly (HP:0001339)	1.81963602
91	Renal Fanconi syndrome (HP:0001994)	1.81850637
92	Abnormality of glycine metabolism (HP:0010895)	1.81426364
93	Abnormality of serine family amino acid metabolism (HP:0010894)	1.81426364
94	Vacuolated lymphocytes (HP:0001922)	1.80440691
95	Type 2 muscle fiber atrophy (HP:0003554)	1.80339278
96	Alkalosis (HP:0001948)	1.79865829
97	CNS demyelination (HP:0007305)	1.79624621
98	Visual hallucinations (HP:0002367)	1.78950631
99	Lethargy (HP:0001254)	1.78522739
100	Thyroiditis (HP:0100646)	1.77671537

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	3.63907253
2	BCKDK	3.59861464
3	BUB1	3.08211060
4	ZAK	2.96779164
5	WNK3	2.88846518
6	MAP3K13	2.81801969
7	TRIM28	2.63821799
8	ADRBK2	2.46420302
9	TXK	2.39287222
10	VRK2	2.39123190
11	BCR	2.24620457
12	FRK	2.23636751
13	FES	2.07108468
14	ACVR1B	2.02273663
15	NUAK1	1.99935511
16	STK16	1.94324792
17	TAOK3	1.87968427
18	TESK2	1.84410045
19	BMPR1B	1.81290946
20	EIF2AK3	1.73954739
21	GRK1	1.68814979
22	MAP2K2	1.50659737
23	MAP3K14	1.46550575
24	TSSK6	1.41957222
25	PIK3CA	1.37322660
26	IKBKB	1.35115412
27	PDK2	1.34688925
28	VRK1	1.33465104
29	CAMKK2	1.31482924
30	PASK	1.26123776
31	CDC42BPA	1.24321874
32	MKNK2	1.23545828
33	MAP2K6	1.20244439
34	MST4	1.19404506
35	CDK8	1.17156920
36	WNK4	1.14938934
37	MAP3K7	1.14176126
38	MAP4K1	1.11961172
39	GRK5	1.07409291
40	KDR	1.03823401
41	TGFBR2	1.01536027
42	MAPKAPK3	0.97623865
43	STK39	0.97569161
44	PINK1	0.96169220
45	DAPK2	0.94911895
46	MAP4K2	0.90609947
47	TIE1	0.87628040
48	CSNK1G3	0.87448264
49	OXSR1	0.87041270
50	NME1	0.85918422
51	ADRBK1	0.84440851
52	EIF2AK2	0.82064291
53	PLK4	0.81923444
54	ITK	0.80423680
55	TAF1	0.78613153
56	MKNK1	0.77371334
57	PLK3	0.74781475
58	PRKCQ	0.73705766
59	PAK3	0.71871245
60	CSNK1A1L	0.71169012
61	ATR	0.70815107
62	DAPK1	0.68168287
63	TTK	0.66802963
64	PIM1	0.66572113
65	ARAF	0.66157132
66	CHUK	0.62661096
67	FER	0.62593875
68	RPS6KA5	0.61834313
69	CSNK1G2	0.61625162
70	CSNK1G1	0.60832425
71	TEC	0.60637476
72	STK3	0.58572900
73	SRPK1	0.58153441
74	EIF2AK1	0.57616847
75	STK4	0.56765098
76	TGFBR1	0.54595828
77	GRK7	0.52423390
78	STK38L	0.49597306
79	PRKCG	0.49381988
80	INSRR	0.49327702
81	ALK	0.44855863
82	BRSK2	0.44693988
83	CAMKK1	0.43581906
84	LMTK2	0.43549728
85	MAPKAPK5	0.43230779
86	TBK1	0.43023519
87	PRKCE	0.40157896
88	PIM2	0.39415599
89	MAP2K1	0.36104402
90	PTK2B	0.35093141
91	TRPM7	0.34559079
92	PHKG2	0.34360367
93	PHKG1	0.34360367
94	CSNK1D	0.33434682
95	PRKCA	0.32866256
96	WEE1	0.32480832
97	PRKCI	0.31089487
98	SYK	0.30823217
99	GRK6	0.30807336
100	MUSK	0.30556443

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	5.98482375
2	Proteasome_Homo sapiens_hsa03050	3.49266445
3	One carbon pool by folate_Homo sapiens_hsa00670	2.68581624
4	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.34269164
5	Phototransduction_Homo sapiens_hsa04744	2.07113865
6	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.05557511
7	Non-homologous end-joining_Homo sapiens_hsa03450	1.99235128
8	Mismatch repair_Homo sapiens_hsa03430	1.92645629
9	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.91224921
10	RNA polymerase_Homo sapiens_hsa03020	1.90497206
11	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.80084608
12	Caffeine metabolism_Homo sapiens_hsa00232	1.77274098
13	Protein export_Homo sapiens_hsa03060	1.76694108
14	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.74461514
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.69991581
16	Propanoate metabolism_Homo sapiens_hsa00640	1.69617915
17	Homologous recombination_Homo sapiens_hsa03440	1.69458827
18	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.68004374
19	Allograft rejection_Homo sapiens_hsa05330	1.64505788
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.61816360
21	Type I diabetes mellitus_Homo sapiens_hsa04940	1.59814090
22	Graft-versus-host disease_Homo sapiens_hsa05332	1.57836484
23	Rheumatoid arthritis_Homo sapiens_hsa05323	1.50953985
24	Phenylalanine metabolism_Homo sapiens_hsa00360	1.50447318
25	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.50136596
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.49152140
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.49131385
28	Oxidative phosphorylation_Homo sapiens_hsa00190	1.48635509
29	Selenocompound metabolism_Homo sapiens_hsa00450	1.42508908
30	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.41090883
31	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.32377769
32	Sulfur metabolism_Homo sapiens_hsa00920	1.30527092
33	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.29049805
34	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.24182066
35	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.23687336
36	Nitrogen metabolism_Homo sapiens_hsa00910	1.23514040
37	RNA degradation_Homo sapiens_hsa03018	1.21315247
38	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.19741284
39	Fatty acid elongation_Homo sapiens_hsa00062	1.18846088
40	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.16533695
41	Linoleic acid metabolism_Homo sapiens_hsa00591	1.12552786
42	Peroxisome_Homo sapiens_hsa04146	1.10815959
43	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.10373592
44	Purine metabolism_Homo sapiens_hsa00230	1.03951168
45	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.02568123
46	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.00249222
47	Primary immunodeficiency_Homo sapiens_hsa05340	0.98822214
48	Parkinsons disease_Homo sapiens_hsa05012	0.97934867
49	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.97169366
50	Butanoate metabolism_Homo sapiens_hsa00650	0.96643264
51	RNA transport_Homo sapiens_hsa03013	0.94487981
52	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.89393380
53	Steroid biosynthesis_Homo sapiens_hsa00100	0.88945839
54	Collecting duct acid secretion_Homo sapiens_hsa04966	0.88719856
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.86714888
56	DNA replication_Homo sapiens_hsa03030	0.86107059
57	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.84933194
58	Nucleotide excision repair_Homo sapiens_hsa03420	0.84497439
59	Antigen processing and presentation_Homo sapiens_hsa04612	0.83597047
60	Regulation of autophagy_Homo sapiens_hsa04140	0.82651393
61	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.81941509
62	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.81013648
63	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.77122101
64	Asthma_Homo sapiens_hsa05310	0.76605295
65	Pyrimidine metabolism_Homo sapiens_hsa00240	0.75749601
66	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.68184217
67	Tyrosine metabolism_Homo sapiens_hsa00350	0.67700418
68	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.60275976
69	Chemical carcinogenesis_Homo sapiens_hsa05204	0.60168490
70	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.59752028
71	Ether lipid metabolism_Homo sapiens_hsa00565	0.59179381
72	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.57436692
73	Metabolic pathways_Homo sapiens_hsa01100	0.57156919
74	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.55960065
75	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.54883005
76	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.54122060
77	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.52900187
78	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.51684058
79	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.49608569
80	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.48978675
81	Glutathione metabolism_Homo sapiens_hsa00480	0.47874676
82	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.46134500
83	Retinol metabolism_Homo sapiens_hsa00830	0.44398924
84	Fat digestion and absorption_Homo sapiens_hsa04975	0.44214265
85	Basal transcription factors_Homo sapiens_hsa03022	0.42855844
86	ABC transporters_Homo sapiens_hsa02010	0.40910398
87	Alzheimers disease_Homo sapiens_hsa05010	0.39837309
88	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.39608651
89	Olfactory transduction_Homo sapiens_hsa04740	0.38257751
90	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.37921375
91	Spliceosome_Homo sapiens_hsa03040	0.35416809
92	Morphine addiction_Homo sapiens_hsa05032	0.34476883
93	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.31075726
94	beta-Alanine metabolism_Homo sapiens_hsa00410	0.30803320
95	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.30776138
96	Huntingtons disease_Homo sapiens_hsa05016	0.30242869
97	Measles_Homo sapiens_hsa05162	0.29217022
98	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.28684777
99	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.27438085
100	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.26454142

XRCC6P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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