ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	7.98426038
2	protein polyglutamylation (GO:0018095)	5.66125920
3	regulation of nuclear cell cycle DNA replication (GO:0033262)	5.57972663
4	pyrimidine nucleobase catabolic process (GO:0006208)	4.80905705
5	DNA deamination (GO:0045006)	4.48296826
6	kynurenine metabolic process (GO:0070189)	4.23954731
7	respiratory chain complex IV assembly (GO:0008535)	4.08359569
8	mitochondrial respiratory chain complex assembly (GO:0033108)	4.04938535
9	protein complex biogenesis (GO:0070271)	4.02534559
10	behavioral response to nicotine (GO:0035095)	4.01889340
11	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.01418983
12	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.01418983
13	NADH dehydrogenase complex assembly (GO:0010257)	4.01418983
14	DNA demethylation (GO:0080111)	3.99070800
15	ATP synthesis coupled proton transport (GO:0015986)	3.92236870
16	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.92236870
17	replication fork processing (GO:0031297)	3.84714674
18	nucleobase catabolic process (GO:0046113)	3.84359122
19	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.84035508
20	protein neddylation (GO:0045116)	3.80575373
21	resolution of meiotic recombination intermediates (GO:0000712)	3.78767288
22	preassembly of GPI anchor in ER membrane (GO:0016254)	3.69645884
23	DNA double-strand break processing (GO:0000729)	3.68267011
24	protein K11-linked deubiquitination (GO:0035871)	3.46422704
25	protein K6-linked ubiquitination (GO:0085020)	3.43547717
26	tryptophan catabolic process (GO:0006569)	3.41258127
27	indole-containing compound catabolic process (GO:0042436)	3.41258127
28	indolalkylamine catabolic process (GO:0046218)	3.41258127
29	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.41094114
30	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.35917959
31	ubiquinone biosynthetic process (GO:0006744)	3.33844253
32	regulation of action potential (GO:0098900)	3.32417606
33	cytochrome complex assembly (GO:0017004)	3.27705440
34	amine catabolic process (GO:0009310)	3.23695142
35	cellular biogenic amine catabolic process (GO:0042402)	3.23695142
36	fucose catabolic process (GO:0019317)	3.22899953
37	L-fucose metabolic process (GO:0042354)	3.22899953
38	L-fucose catabolic process (GO:0042355)	3.22899953
39	DNA dealkylation (GO:0035510)	3.22541815
40	response to redox state (GO:0051775)	3.13391249
41	kidney morphogenesis (GO:0060993)	3.13182296
42	ubiquinone metabolic process (GO:0006743)	3.11321805
43	establishment of epithelial cell polarity (GO:0090162)	3.11317126
44	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.10489588
45	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.07106665
46	regulation of memory T cell differentiation (GO:0043380)	3.00273809
47	indolalkylamine metabolic process (GO:0006586)	2.99348732
48	oxidative demethylation (GO:0070989)	2.96345358
49	water-soluble vitamin biosynthetic process (GO:0042364)	2.95241420
50	cytidine deamination (GO:0009972)	2.92025076
51	cytidine metabolic process (GO:0046087)	2.92025076
52	cytidine catabolic process (GO:0006216)	2.92025076
53	positive regulation of glycoprotein biosynthetic process (GO:0010560)	2.90920478
54	tRNA modification (GO:0006400)	2.90717903
55	tRNA processing (GO:0008033)	2.89380685
56	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.82104430
57	lysine metabolic process (GO:0006553)	2.81493064
58	lysine catabolic process (GO:0006554)	2.81493064
59	chaperone-mediated protein transport (GO:0072321)	2.79739845
60	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.78783268
61	positive regulation of defense response to virus by host (GO:0002230)	2.77297308
62	quinone biosynthetic process (GO:1901663)	2.77164819
63	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	2.76446108
64	negative regulation of cell killing (GO:0031342)	2.76446108
65	presynaptic membrane assembly (GO:0097105)	2.72590691
66	DNA damage response, detection of DNA damage (GO:0042769)	2.71201941
67	cilium morphogenesis (GO:0060271)	2.69134929
68	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.68784864
69	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.68744001
70	mast cell activation involved in immune response (GO:0002279)	2.68699143
71	mast cell degranulation (GO:0043303)	2.68699143
72	adaptation of signaling pathway (GO:0023058)	2.66728097
73	pseudouridine synthesis (GO:0001522)	2.66592017
74	recombinational repair (GO:0000725)	2.65544874
75	neuronal action potential propagation (GO:0019227)	2.65424185
76	one-carbon compound transport (GO:0019755)	2.64154418
77	tryptophan metabolic process (GO:0006568)	2.63928536
78	ribosomal small subunit assembly (GO:0000028)	2.62719667
79	negative regulation of telomere maintenance (GO:0032205)	2.62621127
80	neural tube formation (GO:0001841)	2.59449777
81	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.59448226
82	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.59278641
83	positive regulation of prostaglandin secretion (GO:0032308)	2.58453036
84	aspartate family amino acid catabolic process (GO:0009068)	2.58412209
85	photoreceptor cell maintenance (GO:0045494)	2.58245695
86	double-strand break repair via homologous recombination (GO:0000724)	2.57535866
87	DNA methylation or demethylation (GO:0044728)	2.56807343
88	presynaptic membrane organization (GO:0097090)	2.56247672
89	signal peptide processing (GO:0006465)	2.55622224
90	DNA modification (GO:0006304)	2.55588141
91	electron transport chain (GO:0022900)	2.54937330
92	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.54707791
93	adenosine metabolic process (GO:0046085)	2.54517738
94	L-methionine salvage (GO:0071267)	2.54497162
95	L-methionine biosynthetic process (GO:0071265)	2.54497162
96	amino acid salvage (GO:0043102)	2.54497162
97	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.53876476
98	respiratory electron transport chain (GO:0022904)	2.53776192
99	hydrogen ion transmembrane transport (GO:1902600)	2.53402286
100	limb bud formation (GO:0060174)	2.53099563

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.76756984
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.38937322
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.85206920
4	VDR_22108803_ChIP-Seq_LS180_Human	2.68844209
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.66299525
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.66045564
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.60312689
8	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.43843999
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.42795697
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.38361092
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.36061951
12	EWS_26573619_Chip-Seq_HEK293_Human	2.34745023
13	GBX2_23144817_ChIP-Seq_PC3_Human	2.29278408
14	IRF1_19129219_ChIP-ChIP_H3396_Human	2.21678710
15	FUS_26573619_Chip-Seq_HEK293_Human	2.21526487
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.21128157
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.04212606
18	P300_19829295_ChIP-Seq_ESCs_Human	1.95477037
19	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.93357217
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.88805103
21	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.87174050
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.87030506
23	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.85379895
24	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.82450853
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.76043347
26	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.73324338
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.72547955
28	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.69618042
29	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.66245027
30	TAF15_26573619_Chip-Seq_HEK293_Human	1.65603558
31	ER_23166858_ChIP-Seq_MCF-7_Human	1.64685122
32	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.60715259
33	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.60325379
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.55142719
35	CBP_20019798_ChIP-Seq_JUKART_Human	1.51787358
36	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.51787358
37	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.48261868
38	VDR_23849224_ChIP-Seq_CD4+_Human	1.46073904
39	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.42473179
40	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.42057310
41	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.41704417
42	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.41236458
43	AR_21572438_ChIP-Seq_LNCaP_Human	1.41227266
44	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.40402607
45	AR_20517297_ChIP-Seq_VCAP_Human	1.38941972
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.36276613
47	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.35834340
48	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.35210889
49	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.34894685
50	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.33767878
51	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.33392443
52	ELK1_19687146_ChIP-ChIP_HELA_Human	1.32707272
53	FOXP3_21729870_ChIP-Seq_TREG_Human	1.32635286
54	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.32157537
55	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.31863614
56	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.29554900
57	BCAT_22108803_ChIP-Seq_LS180_Human	1.27068905
58	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.26572726
59	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.24058856
60	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.21021741
61	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.21006317
62	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.18165139
63	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.18165139
64	REST_21632747_ChIP-Seq_MESCs_Mouse	1.17324461
65	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.17271710
66	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.16889704
67	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16720917
68	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.16720917
69	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.16640282
70	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.16213705
71	TCF4_22108803_ChIP-Seq_LS180_Human	1.15326049
72	SMAD4_21799915_ChIP-Seq_A2780_Human	1.14292222
73	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.13650336
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.13139710
75	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.13071061
76	HTT_18923047_ChIP-ChIP_STHdh_Human	1.12063589
77	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.12008622
78	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.09710115
79	HOXB7_26014856_ChIP-Seq_BT474_Human	1.08248976
80	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.08195133
81	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.07736315
82	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.07146047
83	NCOR_22424771_ChIP-Seq_293T_Human	1.07104662
84	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.06184005
85	AR_25329375_ChIP-Seq_VCAP_Human	1.06025439
86	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.05939831
87	NANOG_19829295_ChIP-Seq_ESCs_Human	1.04376570
88	SOX2_19829295_ChIP-Seq_ESCs_Human	1.04376570
89	RUNX2_22187159_ChIP-Seq_PCA_Human	1.04289983
90	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.03740147
91	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.03530832
92	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02206686
93	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.01296349
94	CDX2_22108803_ChIP-Seq_LS180_Human	0.99368842
95	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.97634979
96	NANOG_20526341_ChIP-Seq_ESCs_Human	0.97431970
97	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.97005876
98	SOX9_26525672_Chip-Seq_HEART_Mouse	0.96922360
99	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.96356304
100	STAT3_23295773_ChIP-Seq_U87_Human	0.96018421

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	4.89505673
2	MP0002736_abnormal_nociception_after	3.26142038
3	MP0001529_abnormal_vocalization	3.13174581
4	MP0002102_abnormal_ear_morphology	3.04900176
5	MP0003121_genomic_imprinting	2.85046929
6	MP0001968_abnormal_touch/_nociception	2.72463781
7	MP0005423_abnormal_somatic_nervous	2.62168811
8	MP0008877_abnormal_DNA_methylation	2.38796927
9	MP0006276_abnormal_autonomic_nervous	2.35754297
10	MP0005084_abnormal_gallbladder_morpholo	2.30947882
11	MP0003880_abnormal_central_pattern	2.30138581
12	MP0005253_abnormal_eye_physiology	2.21036913
13	MP0003806_abnormal_nucleotide_metabolis	2.06326781
14	MP0006072_abnormal_retinal_apoptosis	2.06110341
15	MP0000569_abnormal_digit_pigmentation	1.95208936
16	MP0005377_hearing/vestibular/ear_phenot	1.92370210
17	MP0003878_abnormal_ear_physiology	1.92370210
18	MP0005551_abnormal_eye_electrophysiolog	1.92040984
19	MP0004142_abnormal_muscle_tone	1.82975319
20	MP0004133_heterotaxia	1.79090624
21	MP0000566_synostosis	1.78088357
22	MP0008007_abnormal_cellular_replicative	1.73961167
23	MP0008872_abnormal_physiological_respon	1.72226346
24	MP0002163_abnormal_gland_morphology	1.64936424
25	MP0001485_abnormal_pinna_reflex	1.61975320
26	MP0002837_dystrophic_cardiac_calcinosis	1.58653109
27	MP0005646_abnormal_pituitary_gland	1.58046242
28	MP0004885_abnormal_endolymph	1.57294244
29	MP0003195_calcinosis	1.55217160
30	MP0001984_abnormal_olfaction	1.53265408
31	MP0000778_abnormal_nervous_system	1.52313091
32	MP0002557_abnormal_social/conspecific_i	1.51911912
33	MP0000427_abnormal_hair_cycle	1.48771881
34	MP0003890_abnormal_embryonic-extraembry	1.47745230
35	MP0010386_abnormal_urinary_bladder	1.45079405
36	MP0008058_abnormal_DNA_repair	1.44828764
37	MP0004924_abnormal_behavior	1.44426606
38	MP0005386_behavior/neurological_phenoty	1.44426606
39	MP0003646_muscle_fatigue	1.41090582
40	MP0009764_decreased_sensitivity_to	1.30276629
41	MP0003786_premature_aging	1.30119495
42	MP0006292_abnormal_olfactory_placode	1.30100851
43	MP0000631_abnormal_neuroendocrine_gland	1.28665632
44	MP0002938_white_spotting	1.25175699
45	MP0004043_abnormal_pH_regulation	1.24095851
46	MP0001346_abnormal_lacrimal_gland	1.23899081
47	MP0004147_increased_porphyrin_level	1.23112187
48	MP0003186_abnormal_redox_activity	1.22406277
49	MP0002876_abnormal_thyroid_physiology	1.17945970
50	MP0001919_abnormal_reproductive_system	1.13469066
51	MP0003119_abnormal_digestive_system	1.13275757
52	MP0008875_abnormal_xenobiotic_pharmacok	1.12348270
53	MP0006035_abnormal_mitochondrial_morpho	1.12170933
54	MP0009745_abnormal_behavioral_response	1.11957152
55	MP0005645_abnormal_hypothalamus_physiol	1.10592134
56	MP0002184_abnormal_innervation	1.10040670
57	MP0000372_irregular_coat_pigmentation	1.09142011
58	MP0002572_abnormal_emotion/affect_behav	1.08869390
59	MP0004742_abnormal_vestibular_system	1.08780654
60	MP0003635_abnormal_synaptic_transmissio	1.08537266
61	MP0003718_maternal_effect	1.05453135
62	MP0005195_abnormal_posterior_eye	1.05344187
63	MP0001905_abnormal_dopamine_level	1.01775566
64	MP0000647_abnormal_sebaceous_gland	0.98873912
65	MP0002272_abnormal_nervous_system	0.98803689
66	MP0005410_abnormal_fertilization	0.98700829
67	MP0004484_altered_response_of	0.97499788
68	MP0005671_abnormal_response_to	0.95177528
69	MP0002752_abnormal_somatic_nervous	0.92371985
70	MP0004270_analgesia	0.92248763
71	MP0003123_paternal_imprinting	0.89297491
72	MP0000026_abnormal_inner_ear	0.88288041
73	MP0000230_abnormal_systemic_arterial	0.87179590
74	MP0001963_abnormal_hearing_physiology	0.86993214
75	MP0002734_abnormal_mechanical_nocicepti	0.85762383
76	MP0002063_abnormal_learning/memory/cond	0.85720657
77	MP0001486_abnormal_startle_reflex	0.83948432
78	MP0003937_abnormal_limbs/digits/tail_de	0.83621304
79	MP0002067_abnormal_sensory_capabilities	0.83034332
80	MP0001970_abnormal_pain_threshold	0.82464382
81	MP0003122_maternal_imprinting	0.80360883
82	MP0002733_abnormal_thermal_nociception	0.79328434
83	MP0004957_abnormal_blastocyst_morpholog	0.78797393
84	MP0005389_reproductive_system_phenotype	0.78779571
85	MP0010329_abnormal_lipoprotein_level	0.77511047
86	MP0000955_abnormal_spinal_cord	0.75917264
87	MP0003567_abnormal_fetal_cardiomyocyte	0.75815073
88	MP0005391_vision/eye_phenotype	0.75608141
89	MP0006054_spinal_hemorrhage	0.75338247
90	MP0001764_abnormal_homeostasis	0.74901878
91	MP0004145_abnormal_muscle_electrophysio	0.74451098
92	MP0000538_abnormal_urinary_bladder	0.74287690
93	MP0010094_abnormal_chromosome_stability	0.73809119
94	MP0005647_abnormal_sex_gland	0.72076548
95	MP0009765_abnormal_xenobiotic_induced	0.71866236
96	MP0002822_catalepsy	0.71089690
97	MP0002277_abnormal_respiratory_mucosa	0.70918415
98	MP0004215_abnormal_myocardial_fiber	0.70650527
99	MP0000049_abnormal_middle_ear	0.69599928
100	MP0001727_abnormal_embryo_implantation	0.68613249

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Renal cortical cysts (HP:0000803)	3.65730434
2	Volvulus (HP:0002580)	3.56073306
3	Congenital stationary night blindness (HP:0007642)	3.48342018
4	3-Methylglutaconic aciduria (HP:0003535)	3.22711001
5	Abnormality of the labia minora (HP:0012880)	3.19877796
6	Abnormality of alanine metabolism (HP:0010916)	3.12304414
7	Hyperalaninemia (HP:0003348)	3.12304414
8	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.12304414
9	Abolished electroretinogram (ERG) (HP:0000550)	3.08670819
10	Pancreatic cysts (HP:0001737)	3.06767314
11	Abnormality of the renal cortex (HP:0011035)	3.04897211
12	Methylmalonic acidemia (HP:0002912)	3.01339082
13	Progressive inability to walk (HP:0002505)	3.00758583
14	Pancreatic fibrosis (HP:0100732)	2.99660177
15	Pendular nystagmus (HP:0012043)	2.99324375
16	Increased serum lactate (HP:0002151)	2.93894444
17	Elevated erythrocyte sedimentation rate (HP:0003565)	2.87622855
18	Attenuation of retinal blood vessels (HP:0007843)	2.74127064
19	Nephronophthisis (HP:0000090)	2.73289059
20	Inability to walk (HP:0002540)	2.62071686
21	Prolonged neonatal jaundice (HP:0006579)	2.59847992
22	Abnormality of the renal medulla (HP:0100957)	2.57922613
23	True hermaphroditism (HP:0010459)	2.54528390
24	Stomach cancer (HP:0012126)	2.50587993
25	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.50525277
26	Confusion (HP:0001289)	2.46369329
27	Optic disc pallor (HP:0000543)	2.44640649
28	Abnormality of cells of the erythroid lineage (HP:0012130)	2.36732466
29	Enlarged kidneys (HP:0000105)	2.35843046
30	Lissencephaly (HP:0001339)	2.35300204
31	Abnormal number of erythroid precursors (HP:0012131)	2.32704618
32	Increased CSF lactate (HP:0002490)	2.32652607
33	Delayed CNS myelination (HP:0002188)	2.31291033
34	Small hand (HP:0200055)	2.30503838
35	Mitochondrial inheritance (HP:0001427)	2.27578597
36	Broad-based gait (HP:0002136)	2.27565857
37	Synostosis involving the elbow (HP:0003938)	2.27116253
38	Humeroradial synostosis (HP:0003041)	2.27116253
39	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.25999620
40	Hepatic necrosis (HP:0002605)	2.24008490
41	Adrenal hypoplasia (HP:0000835)	2.22051184
42	Hepatocellular necrosis (HP:0001404)	2.20421994
43	Keratoconus (HP:0000563)	2.20197122
44	Increased corneal curvature (HP:0100692)	2.20197122
45	Acute necrotizing encephalopathy (HP:0006965)	2.17822530
46	Methylmalonic aciduria (HP:0012120)	2.17046367
47	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.16726723
48	Meckel diverticulum (HP:0002245)	2.15987777
49	Hemiparesis (HP:0001269)	2.14363629
50	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.13591529
51	Abnormal mitochondria in muscle tissue (HP:0008316)	2.13204100
52	Abnormality of serum amino acid levels (HP:0003112)	2.11220790
53	Progressive cerebellar ataxia (HP:0002073)	2.09892609
54	Hyperglycinuria (HP:0003108)	2.09268366
55	Abnormal rod and cone electroretinograms (HP:0008323)	2.07925787
56	Hyperventilation (HP:0002883)	2.07705866
57	Chorioretinal atrophy (HP:0000533)	2.07349863
58	Acute encephalopathy (HP:0006846)	2.05523912
59	Abnormality of midbrain morphology (HP:0002418)	2.05362848
60	Molar tooth sign on MRI (HP:0002419)	2.05362848
61	Increased hepatocellular lipid droplets (HP:0006565)	2.04073123
62	Sclerocornea (HP:0000647)	2.02813748
63	Hyperglycinemia (HP:0002154)	2.02755661
64	Increased serum pyruvate (HP:0003542)	2.02395044
65	Medial flaring of the eyebrow (HP:0010747)	2.01590838
66	Asplenia (HP:0001746)	2.01071424
67	Abnormality of the ileum (HP:0001549)	2.01025812
68	Pachygyria (HP:0001302)	2.00071002
69	Lipid accumulation in hepatocytes (HP:0006561)	1.99689202
70	Type II lissencephaly (HP:0007260)	1.96790759
71	Absent thumb (HP:0009777)	1.96502326
72	Supernumerary spleens (HP:0009799)	1.96309208
73	Stenosis of the external auditory canal (HP:0000402)	1.94397500
74	Abnormality of glycine metabolism (HP:0010895)	1.93708046
75	Abnormality of serine family amino acid metabolism (HP:0010894)	1.93708046
76	Neoplasm of the adrenal cortex (HP:0100641)	1.92277983
77	Hypochromic microcytic anemia (HP:0004840)	1.91648137
78	Triphalangeal thumb (HP:0001199)	1.90780845
79	Respiratory distress (HP:0002098)	1.89343952
80	Generalized aminoaciduria (HP:0002909)	1.86526889
81	Progressive macrocephaly (HP:0004481)	1.85506359
82	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.84537007
83	Hypothermia (HP:0002045)	1.83207487
84	Dandy-Walker malformation (HP:0001305)	1.81463255
85	Protruding tongue (HP:0010808)	1.81002480
86	Thyroiditis (HP:0100646)	1.79761755
87	Anencephaly (HP:0002323)	1.79284729
88	Shawl scrotum (HP:0000049)	1.78976501
89	Parakeratosis (HP:0001036)	1.78250237
90	Birth length less than 3rd percentile (HP:0003561)	1.77743083
91	Lactic acidosis (HP:0003128)	1.75693842
92	Esophageal atresia (HP:0002032)	1.74156708
93	Bony spicule pigmentary retinopathy (HP:0007737)	1.74102676
94	Drooling (HP:0002307)	1.72565661
95	Hypoplasia of the fovea (HP:0007750)	1.72220537
96	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.72220537
97	Preaxial hand polydactyly (HP:0001177)	1.70695596
98	Cerebellar dysplasia (HP:0007033)	1.70556714
99	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.70291627
100	Abnormality of vitamin B metabolism (HP:0004340)	1.68882759

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	3.71985220
2	STK16	3.44032723
3	MAP4K2	3.26533833
4	FRK	3.04212343
5	WNK3	2.71351706
6	VRK2	2.58498241
7	NUAK1	2.58395124
8	DYRK2	2.31574062
9	NEK1	2.20393768
10	TAOK3	2.16471256
11	EPHA4	2.02599706
12	FGFR2	1.98448494
13	MST4	1.87959242
14	ADRBK2	1.87046700
15	TLK1	1.79078317
16	PBK	1.70829772
17	TXK	1.69910196
18	MARK1	1.54727665
19	CASK	1.54593062
20	TGFBR1	1.49776441
21	PASK	1.49755786
22	BCR	1.47037760
23	MAPK13	1.42775221
24	GRK1	1.37374148
25	BMPR1B	1.32612182
26	PNCK	1.32525814
27	MKNK1	1.27365895
28	DAPK2	1.26502649
29	MAP3K12	1.22776952
30	VRK1	1.20825875
31	BCKDK	1.18066539
32	PINK1	1.12661811
33	TAF1	1.11936480
34	WNK4	1.11395008
35	MAP3K7	1.09855349
36	INSRR	1.09170541
37	PRKCG	1.08604225
38	CAMK1G	1.06990571
39	CSNK1G2	1.01451620
40	PKN1	1.00201452
41	OXSR1	0.98773277
42	CDC7	0.97410285
43	MKNK2	0.96651714
44	TGFBR2	0.96562406
45	PLK4	0.96433163
46	ATR	0.95568490
47	CAMK1D	0.94159030
48	SRPK1	0.90497237
49	TIE1	0.89012036
50	STK39	0.88708807
51	PRKCQ	0.85407915
52	MUSK	0.85305297
53	PRKCH	0.81330985
54	PLK3	0.80603613
55	MAP4K1	0.80340521
56	TNK2	0.77566161
57	GRK6	0.73714984
58	MAPKAPK5	0.73600295
59	PDK2	0.73029189
60	CSNK1G3	0.71106242
61	BUB1	0.67792321
62	PHKG1	0.67062577
63	PHKG2	0.67062577
64	NEK2	0.66048093
65	CAMK1	0.66035714
66	GRK5	0.65849986
67	AURKB	0.65631788
68	PIK3CA	0.61784421
69	CSNK1A1L	0.60507084
70	PLK2	0.60433402
71	EIF2AK3	0.59597419
72	CSNK1G1	0.58295922
73	FES	0.57810997
74	NME1	0.56595090
75	CAMKK2	0.54707181
76	TNIK	0.54454389
77	ADRBK1	0.54390518
78	DAPK1	0.54309484
79	MYLK	0.51573923
80	KIT	0.51019745
81	TYRO3	0.50846052
82	MATK	0.48493006
83	RPS6KA4	0.47931032
84	EIF2AK2	0.46793446
85	DYRK1B	0.46475666
86	MAP3K4	0.46302007
87	ATM	0.46169622
88	PRKCE	0.45358117
89	DAPK3	0.45334858
90	CHEK2	0.45143213
91	PRKACA	0.40475663
92	PRKCA	0.38010254
93	PLK1	0.37920016
94	TTK	0.36514502
95	PRKDC	0.35709600
96	RPS6KA5	0.35694067
97	PRKCD	0.35598915
98	CAMK4	0.34874129
99	SYK	0.34461742
100	PRKCI	0.33603983

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	2.99694808
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.84411145
3	Proteasome_Homo sapiens_hsa03050	2.60283928
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.55748554
5	Steroid biosynthesis_Homo sapiens_hsa00100	2.51850162
6	Parkinsons disease_Homo sapiens_hsa05012	2.38136371
7	Protein export_Homo sapiens_hsa03060	2.36311717
8	Propanoate metabolism_Homo sapiens_hsa00640	2.34707325
9	Ribosome_Homo sapiens_hsa03010	2.30580321
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.19912778
11	Non-homologous end-joining_Homo sapiens_hsa03450	2.19751285
12	Fanconi anemia pathway_Homo sapiens_hsa03460	2.17943591
13	Homologous recombination_Homo sapiens_hsa03440	2.04246478
14	Phototransduction_Homo sapiens_hsa04744	1.99546511
15	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.98029996
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.88314614
17	Butanoate metabolism_Homo sapiens_hsa00650	1.86346336
18	Basal transcription factors_Homo sapiens_hsa03022	1.84234220
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.81078412
20	Alzheimers disease_Homo sapiens_hsa05010	1.80102855
21	Selenocompound metabolism_Homo sapiens_hsa00450	1.62574109
22	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.60567845
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.59573121
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.59536032
25	Nicotine addiction_Homo sapiens_hsa05033	1.54849068
26	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.50255146
27	Huntingtons disease_Homo sapiens_hsa05016	1.47711474
28	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.42020658
29	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.41900200
30	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.39565574
31	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.38004269
32	Cardiac muscle contraction_Homo sapiens_hsa04260	1.35235055
33	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.32663068
34	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.28906921
35	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.26175261
36	RNA polymerase_Homo sapiens_hsa03020	1.22238139
37	Mismatch repair_Homo sapiens_hsa03430	1.22024119
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.17367004
39	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.15930810
40	RNA degradation_Homo sapiens_hsa03018	1.13497852
41	One carbon pool by folate_Homo sapiens_hsa00670	1.09524356
42	Nitrogen metabolism_Homo sapiens_hsa00910	1.03727257
43	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.01518968
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.00311838
45	Peroxisome_Homo sapiens_hsa04146	0.93409835
46	Asthma_Homo sapiens_hsa05310	0.92766442
47	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.92695146
48	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.90569422
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.90279473
50	Pyruvate metabolism_Homo sapiens_hsa00620	0.87661871
51	Nucleotide excision repair_Homo sapiens_hsa03420	0.87229665
52	Lysine degradation_Homo sapiens_hsa00310	0.86899233
53	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.83980674
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.79738046
55	RNA transport_Homo sapiens_hsa03013	0.79308702
56	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.76073162
57	Base excision repair_Homo sapiens_hsa03410	0.75684772
58	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.75398757
59	Retinol metabolism_Homo sapiens_hsa00830	0.74642686
60	beta-Alanine metabolism_Homo sapiens_hsa00410	0.73133225
61	Metabolic pathways_Homo sapiens_hsa01100	0.72662481
62	Fat digestion and absorption_Homo sapiens_hsa04975	0.70623220
63	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.70099405
64	Graft-versus-host disease_Homo sapiens_hsa05332	0.69755459
65	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.68380382
66	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.68258556
67	Primary immunodeficiency_Homo sapiens_hsa05340	0.66647217
68	Morphine addiction_Homo sapiens_hsa05032	0.66195285
69	Purine metabolism_Homo sapiens_hsa00230	0.66132273
70	Taste transduction_Homo sapiens_hsa04742	0.65014491
71	Spliceosome_Homo sapiens_hsa03040	0.64943017
72	Pyrimidine metabolism_Homo sapiens_hsa00240	0.64572181
73	Glutamatergic synapse_Homo sapiens_hsa04724	0.63435645
74	Glycerolipid metabolism_Homo sapiens_hsa00561	0.61301010
75	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.60477916
76	Amphetamine addiction_Homo sapiens_hsa05031	0.60046457
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.60004716
78	Circadian entrainment_Homo sapiens_hsa04713	0.58681718
79	Olfactory transduction_Homo sapiens_hsa04740	0.56907351
80	GABAergic synapse_Homo sapiens_hsa04727	0.52710731
81	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.51731146
82	Caffeine metabolism_Homo sapiens_hsa00232	0.50305613
83	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.48941585
84	Salivary secretion_Homo sapiens_hsa04970	0.48616226
85	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.48394325
86	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.47679054
87	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.45975675
88	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.43564778
89	Glutathione metabolism_Homo sapiens_hsa00480	0.42996969
90	Arginine and proline metabolism_Homo sapiens_hsa00330	0.42020090
91	Dopaminergic synapse_Homo sapiens_hsa04728	0.41930135
92	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.41853715
93	Ether lipid metabolism_Homo sapiens_hsa00565	0.41265822
94	Serotonergic synapse_Homo sapiens_hsa04726	0.40092489
95	Regulation of autophagy_Homo sapiens_hsa04140	0.40002010
96	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.39538986
97	Fatty acid degradation_Homo sapiens_hsa00071	0.39063256
98	Allograft rejection_Homo sapiens_hsa05330	0.37078020
99	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.36452745
100	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.34015112

XRCC6P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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