ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	5.85611287
2	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	5.85611287
3	DNA deamination (GO:0045006)	5.73168784
4	positive regulation of T cell cytokine production (GO:0002726)	5.66931035
5	hyperosmotic salinity response (GO:0042538)	5.40531569
6	preassembly of GPI anchor in ER membrane (GO:0016254)	5.01176365
7	rRNA modification (GO:0000154)	4.90066220
8	positive regulation of prostaglandin secretion (GO:0032308)	4.75899331
9	folic acid-containing compound biosynthetic process (GO:0009396)	4.68099561
10	adenosine metabolic process (GO:0046085)	4.54590125
11	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.37155286
12	NADH dehydrogenase complex assembly (GO:0010257)	4.37155286
13	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.37155286
14	respiratory chain complex IV assembly (GO:0008535)	4.28448723
15	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.28190291
16	cullin deneddylation (GO:0010388)	4.28034772
17	protein polyglutamylation (GO:0018095)	4.18139812
18	DNA ligation (GO:0006266)	4.13877774
19	maturation of 5.8S rRNA (GO:0000460)	4.13799733
20	pseudouridine synthesis (GO:0001522)	4.00640536
21	rRNA methylation (GO:0031167)	3.97213958
22	cytidine metabolic process (GO:0046087)	3.96189355
23	cytidine catabolic process (GO:0006216)	3.96189355
24	cytidine deamination (GO:0009972)	3.96189355
25	mitochondrial RNA metabolic process (GO:0000959)	3.95059573
26	protein deneddylation (GO:0000338)	3.89616012
27	water-soluble vitamin biosynthetic process (GO:0042364)	3.89303491
28	regulation of prostaglandin secretion (GO:0032306)	3.82261780
29	GPI anchor metabolic process (GO:0006505)	3.72316577
30	GPI anchor biosynthetic process (GO:0006506)	3.71014163
31	protein complex biogenesis (GO:0070271)	3.67769468
32	regulation of T cell cytokine production (GO:0002724)	3.65900568
33	cysteine metabolic process (GO:0006534)	3.65052847
34	DNA catabolic process, exonucleolytic (GO:0000738)	3.62193244
35	purine nucleotide salvage (GO:0032261)	3.58885508
36	homocysteine metabolic process (GO:0050667)	3.52650205
37	protein-cofactor linkage (GO:0018065)	3.49401853
38	sulfur amino acid catabolic process (GO:0000098)	3.46752482
39	mitochondrial respiratory chain complex assembly (GO:0033108)	3.41048900
40	regulation of cilium movement (GO:0003352)	3.39411621
41	tRNA modification (GO:0006400)	3.38340399
42	pteridine-containing compound biosynthetic process (GO:0042559)	3.35804566
43	establishment of integrated proviral latency (GO:0075713)	3.35747170
44	cytochrome complex assembly (GO:0017004)	3.35591948
45	regulation of immunoglobulin secretion (GO:0051023)	3.28589353
46	IMP biosynthetic process (GO:0006188)	3.26256157
47	proteasome assembly (GO:0043248)	3.25787208
48	tRNA processing (GO:0008033)	3.24748294
49	tetrahydrofolate metabolic process (GO:0046653)	3.24139576
50	platelet dense granule organization (GO:0060155)	3.22650067
51	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.22307836
52	positive regulation of heat generation (GO:0031652)	3.19136762
53	artery smooth muscle contraction (GO:0014824)	3.10417175
54	mannosylation (GO:0097502)	3.05674491
55	CENP-A containing nucleosome assembly (GO:0034080)	3.04128475
56	L-serine metabolic process (GO:0006563)	3.00879685
57	replication fork processing (GO:0031297)	2.94526959
58	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.93996695
59	chromatin remodeling at centromere (GO:0031055)	2.93541436
60	primary amino compound metabolic process (GO:1901160)	2.92451175
61	establishment of viral latency (GO:0019043)	2.91529607
62	C-terminal protein lipidation (GO:0006501)	2.90620737
63	termination of RNA polymerase III transcription (GO:0006386)	2.89490735
64	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.89490735
65	branched-chain amino acid catabolic process (GO:0009083)	2.89254921
66	DNA double-strand break processing (GO:0000729)	2.87919204
67	tRNA metabolic process (GO:0006399)	2.83600299
68	positive regulation of icosanoid secretion (GO:0032305)	2.82431203
69	microtubule nucleation (GO:0007020)	2.82330877
70	positive regulation of fatty acid transport (GO:2000193)	2.81228900
71	regulation of fever generation (GO:0031620)	2.75719837
72	signal peptide processing (GO:0006465)	2.75496358
73	regulation of T cell chemotaxis (GO:0010819)	2.74116782
74	positive regulation of T cell chemotaxis (GO:0010820)	2.74116782
75	short-chain fatty acid metabolic process (GO:0046459)	2.74053319
76	IMP metabolic process (GO:0046040)	2.73031891
77	branched-chain amino acid metabolic process (GO:0009081)	2.71361945
78	L-fucose catabolic process (GO:0042355)	2.71164997
79	fucose catabolic process (GO:0019317)	2.71164997
80	L-fucose metabolic process (GO:0042354)	2.71164997
81	response to lipoprotein particle (GO:0055094)	2.69652554
82	C-terminal protein amino acid modification (GO:0018410)	2.69064992
83	response to pheromone (GO:0019236)	2.68970541
84	valine metabolic process (GO:0006573)	2.68908620
85	regulation of microtubule-based movement (GO:0060632)	2.68870197
86	RNA modification (GO:0009451)	2.68642744
87	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.67687107
88	regulation of heat generation (GO:0031650)	2.67508352
89	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.67155154
90	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.67155154
91	regulation of glucokinase activity (GO:0033131)	2.65324466
92	regulation of hexokinase activity (GO:1903299)	2.65324466
93	sulfation (GO:0051923)	2.65151842
94	folic acid-containing compound metabolic process (GO:0006760)	2.63365495
95	tonic smooth muscle contraction (GO:0014820)	2.62397595
96	ribosome assembly (GO:0042255)	2.62276819
97	positive regulation of immune response to tumor cell (GO:0002839)	2.59786430
98	regulation of immune response to tumor cell (GO:0002837)	2.59786430
99	regulation of response to tumor cell (GO:0002834)	2.59786430
100	positive regulation of response to tumor cell (GO:0002836)	2.59786430

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.99466128
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.13432411
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.11773975
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.50888643
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.96709588
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.93401420
7	VDR_22108803_ChIP-Seq_LS180_Human	2.84811538
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.82373875
9	E2F7_22180533_ChIP-Seq_HELA_Human	2.59754193
10	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.45874812
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.31359065
12	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.25947874
13	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.23188969
14	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.18177917
15	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.14341597
16	FOXP3_21729870_ChIP-Seq_TREG_Human	2.07187580
17	ELK1_19687146_ChIP-ChIP_HELA_Human	2.06208994
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.05634638
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.03050932
20	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.02635709
21	EWS_26573619_Chip-Seq_HEK293_Human	1.94062238
22	MYC_18940864_ChIP-ChIP_HL60_Human	1.87890089
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.85473105
24	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.83043338
25	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.71370628
26	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.69959119
27	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.63671619
28	TP53_22573176_ChIP-Seq_HFKS_Human	1.57173388
29	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.53483963
30	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.52808687
31	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.52627716
32	IGF1R_20145208_ChIP-Seq_DFB_Human	1.52498545
33	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.51709671
34	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.49750157
35	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.47789993
36	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.46546039
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.44580564
38	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.43753599
39	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.43738582
40	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.43535394
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.41483077
42	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.41483077
43	GBX2_23144817_ChIP-Seq_PC3_Human	1.38688337
44	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.36728621
45	P300_19829295_ChIP-Seq_ESCs_Human	1.36430549
46	GABP_19822575_ChIP-Seq_HepG2_Human	1.36395515
47	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.34134807
48	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.33317593
49	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.32966119
50	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.32966119
51	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.30961177
52	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.29151285
53	AR_20517297_ChIP-Seq_VCAP_Human	1.28477421
54	CDX2_22108803_ChIP-Seq_LS180_Human	1.27382124
55	CIITA_25753668_ChIP-Seq_RAJI_Human	1.27055262
56	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.25096017
57	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.24713382
58	NCOR_22424771_ChIP-Seq_293T_Human	1.23612879
59	HOXB7_26014856_ChIP-Seq_BT474_Human	1.23229657
60	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.22990271
61	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.20503135
62	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.19925379
63	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.18046886
64	FUS_26573619_Chip-Seq_HEK293_Human	1.16576125
65	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.15451301
66	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.13233113
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.11958977
68	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.11511423
69	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10354248
70	SOX2_19829295_ChIP-Seq_ESCs_Human	1.08502728
71	NANOG_19829295_ChIP-Seq_ESCs_Human	1.08502728
72	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.08337625
73	ER_23166858_ChIP-Seq_MCF-7_Human	1.08110789
74	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.07574034
75	HTT_18923047_ChIP-ChIP_STHdh_Human	1.06474497
76	BCAT_22108803_ChIP-Seq_LS180_Human	1.05343352
77	ERG_20517297_ChIP-Seq_VCAP_Human	1.04227080
78	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.04223442
79	IRF1_19129219_ChIP-ChIP_H3396_Human	1.04096985
80	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.02795798
81	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.02321667
82	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.99237744
83	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.99229593
84	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.97617319
85	TCF4_22108803_ChIP-Seq_LS180_Human	0.97116171
86	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.96475996
87	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.96236086
88	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.95910200
89	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.95420728
90	DCP1A_22483619_ChIP-Seq_HELA_Human	0.94493914
91	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.92795172
92	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.92437584
93	MYC_19829295_ChIP-Seq_ESCs_Human	0.91370494
94	TAF2_19829295_ChIP-Seq_ESCs_Human	0.91190036
95	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.90909512
96	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.90723017
97	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.90459420
98	NANOG_20526341_ChIP-Seq_ESCs_Human	0.89909550
99	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.88282603
100	GATA3_26560356_Chip-Seq_TH2_Human	0.86434212

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	4.03702655
2	MP0004885_abnormal_endolymph	2.89295275
3	MP0005360_urolithiasis	2.77757963
4	MP0002736_abnormal_nociception_after	2.70593996
5	MP0002138_abnormal_hepatobiliary_system	2.65933210
6	MP0002102_abnormal_ear_morphology	2.47407676
7	MP0004147_increased_porphyrin_level	2.47088072
8	MP0000013_abnormal_adipose_tissue	2.45996872
9	MP0002876_abnormal_thyroid_physiology	2.44148810
10	MP0001986_abnormal_taste_sensitivity	2.18608510
11	MP0001968_abnormal_touch/_nociception	2.10963017
12	MP0005646_abnormal_pituitary_gland	2.10098945
13	MP0008058_abnormal_DNA_repair	2.04868812
14	MP0008995_early_reproductive_senescence	2.02686813
15	MP0001661_extended_life_span	2.01640788
16	MP0002139_abnormal_hepatobiliary_system	2.00358446
17	MP0008877_abnormal_DNA_methylation	1.99959935
18	MP0003195_calcinosis	1.99240340
19	MP0008872_abnormal_physiological_respon	1.99011300
20	MP0008789_abnormal_olfactory_epithelium	1.93501817
21	MP0003183_abnormal_peptide_metabolism	1.93199079
22	MP0005084_abnormal_gallbladder_morpholo	1.89516532
23	MP0003724_increased_susceptibility_to	1.77071213
24	MP0005551_abnormal_eye_electrophysiolog	1.74565137
25	MP0001529_abnormal_vocalization	1.67793121
26	MP0005253_abnormal_eye_physiology	1.65278968
27	MP0005332_abnormal_amino_acid	1.64787801
28	MP0001764_abnormal_homeostasis	1.64183222
29	MP0005671_abnormal_response_to	1.63702769
30	MP0003786_premature_aging	1.62187984
31	MP0000427_abnormal_hair_cycle	1.61851809
32	MP0003011_delayed_dark_adaptation	1.60101871
33	MP0002163_abnormal_gland_morphology	1.59990377
34	MP0006276_abnormal_autonomic_nervous	1.58058855
35	MP0000372_irregular_coat_pigmentation	1.52814617
36	MP0001984_abnormal_olfaction	1.49543795
37	MP0009780_abnormal_chondrocyte_physiolo	1.47008143
38	MP0006072_abnormal_retinal_apoptosis	1.45292090
39	MP0003718_maternal_effect	1.44981255
40	MP0003693_abnormal_embryo_hatching	1.41513885
41	MP0002837_dystrophic_cardiac_calcinosis	1.39939982
42	MP0008007_abnormal_cellular_replicative	1.39577815
43	MP0003186_abnormal_redox_activity	1.38220269
44	MP0009697_abnormal_copulation	1.37624377
45	MP0010094_abnormal_chromosome_stability	1.36187074
46	MP0004782_abnormal_surfactant_physiolog	1.35685091
47	MP0000685_abnormal_immune_system	1.30203848
48	MP0005085_abnormal_gallbladder_physiolo	1.28648659
49	MP0008875_abnormal_xenobiotic_pharmacok	1.25253369
50	MP0005379_endocrine/exocrine_gland_phen	1.24498696
51	MP0005410_abnormal_fertilization	1.23987801
52	MP0005171_absent_coat_pigmentation	1.15254765
53	MP0006054_spinal_hemorrhage	1.15118358
54	MP0003252_abnormal_bile_duct	1.14913266
55	MP0006035_abnormal_mitochondrial_morpho	1.14851372
56	MP0005499_abnormal_olfactory_system	1.12292634
57	MP0005394_taste/olfaction_phenotype	1.12292634
58	MP0002938_white_spotting	1.11527769
59	MP0002148_abnormal_hypersensitivity_rea	1.07408240
60	MP0005636_abnormal_mineral_homeostasis	1.07212154
61	MP0003787_abnormal_imprinting	1.06963201
62	MP0000538_abnormal_urinary_bladder	1.06660125
63	MP0010386_abnormal_urinary_bladder	1.02791616
64	MP0002095_abnormal_skin_pigmentation	1.02707244
65	MP0008775_abnormal_heart_ventricle	1.01384490
66	MP0004145_abnormal_muscle_electrophysio	1.00596246
67	MP0002234_abnormal_pharynx_morphology	0.98368605
68	MP0000647_abnormal_sebaceous_gland	0.97304784
69	MP0002160_abnormal_reproductive_system	0.95977098
70	MP0000383_abnormal_hair_follicle	0.95476547
71	MP0002928_abnormal_bile_duct	0.95272266
72	MP0004142_abnormal_muscle_tone	0.93748591
73	MP0001486_abnormal_startle_reflex	0.91000005
74	MP0001756_abnormal_urination	0.90237572
75	MP0005167_abnormal_blood-brain_barrier	0.89238687
76	MP0004019_abnormal_vitamin_homeostasis	0.89091817
77	MP0005220_abnormal_exocrine_pancreas	0.87774735
78	MP0005389_reproductive_system_phenotype	0.87467697
79	MP0004043_abnormal_pH_regulation	0.86975511
80	MP0006036_abnormal_mitochondrial_physio	0.86406446
81	MP0009333_abnormal_splenocyte_physiolog	0.86349882
82	MP0005670_abnormal_white_adipose	0.84668588
83	MP0005083_abnormal_biliary_tract	0.82516915
84	MP0000230_abnormal_systemic_arterial	0.81744622
85	MP0009765_abnormal_xenobiotic_induced	0.80992162
86	MP0004957_abnormal_blastocyst_morpholog	0.79758776
87	MP0002723_abnormal_immune_serum	0.79663606
88	MP0000613_abnormal_salivary_gland	0.75624725
89	MP0000631_abnormal_neuroendocrine_gland	0.75253147
90	MP0001835_abnormal_antigen_presentation	0.75125510
91	MP0002735_abnormal_chemical_nociception	0.74527517
92	MP0001929_abnormal_gametogenesis	0.74479434
93	MP0000639_abnormal_adrenal_gland	0.74329624
94	MP0009643_abnormal_urine_homeostasis	0.73176513
95	MP0001963_abnormal_hearing_physiology	0.71636731
96	MP0002006_tumorigenesis	0.70929133
97	MP0001800_abnormal_humoral_immune	0.70855438
98	MP0002653_abnormal_ependyma_morphology	0.68926551
99	MP0001765_abnormal_ion_homeostasis	0.66982728
100	MP0001485_abnormal_pinna_reflex	0.66799041

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of alanine metabolism (HP:0010916)	5.78156810
2	Hyperalaninemia (HP:0003348)	5.78156810
3	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	5.78156810
4	Methylmalonic acidemia (HP:0002912)	4.02538282
5	Attenuation of retinal blood vessels (HP:0007843)	3.46431757
6	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.41158413
7	Methylmalonic aciduria (HP:0012120)	3.37966694
8	Abnormality of serine family amino acid metabolism (HP:0010894)	3.20619379
9	Abnormality of glycine metabolism (HP:0010895)	3.20619379
10	Abnormality of serum amino acid levels (HP:0003112)	3.16079406
11	Congenital sensorineural hearing impairment (HP:0008527)	3.07045307
12	Hyperglycinuria (HP:0003108)	3.01961613
13	Hyperglycinemia (HP:0002154)	3.00393024
14	Increased serum lactate (HP:0002151)	2.97249067
15	Constricted visual fields (HP:0001133)	2.93411546
16	Pancreatic cysts (HP:0001737)	2.90444969
17	Abolished electroretinogram (ERG) (HP:0000550)	2.85548045
18	Abnormality of the labia minora (HP:0012880)	2.68794037
19	Pendular nystagmus (HP:0012043)	2.66939939
20	Elevated erythrocyte sedimentation rate (HP:0003565)	2.60940611
21	Pancytopenia (HP:0001876)	2.57779895
22	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.56726718
23	Abnormality of the renal cortex (HP:0011035)	2.55684256
24	Pancreatic fibrosis (HP:0100732)	2.43922140
25	Acute necrotizing encephalopathy (HP:0006965)	2.42598239
26	Mitochondrial inheritance (HP:0001427)	2.40892202
27	Increased CSF lactate (HP:0002490)	2.38151510
28	Acute encephalopathy (HP:0006846)	2.37013931
29	Duplicated collecting system (HP:0000081)	2.35520395
30	True hermaphroditism (HP:0010459)	2.34508824
31	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.31835612
32	Nephronophthisis (HP:0000090)	2.30136018
33	Spontaneous hematomas (HP:0007420)	2.29858292
34	3-Methylglutaconic aciduria (HP:0003535)	2.29785954
35	Abnormality of the renal collecting system (HP:0004742)	2.26403447
36	Abnormality of the renal medulla (HP:0100957)	2.25202409
37	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.19854725
38	Abnormality of vitamin B metabolism (HP:0004340)	2.19071675
39	Progressive macrocephaly (HP:0004481)	2.18826300
40	Renal cortical cysts (HP:0000803)	2.18072737
41	Lactic acidosis (HP:0003128)	2.16354388
42	Optic disc pallor (HP:0000543)	2.16275213
43	Type I transferrin isoform profile (HP:0003642)	2.15339466
44	Abnormality of DNA repair (HP:0003254)	2.10416127
45	Birth length less than 3rd percentile (HP:0003561)	2.10012029
46	Hepatocellular necrosis (HP:0001404)	2.05784078
47	Abnormal mitochondria in muscle tissue (HP:0008316)	2.05684559
48	Congenital stationary night blindness (HP:0007642)	2.05443896
49	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.05212995
50	Increased corneal curvature (HP:0100692)	1.97847910
51	Keratoconus (HP:0000563)	1.97847910
52	Medial flaring of the eyebrow (HP:0010747)	1.96448872
53	Chronic hepatic failure (HP:0100626)	1.96162752
54	Thyroiditis (HP:0100646)	1.95182171
55	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.95000274
56	Abnormal protein N-linked glycosylation (HP:0012347)	1.95000274
57	Abnormal protein glycosylation (HP:0012346)	1.95000274
58	Abnormal glycosylation (HP:0012345)	1.95000274
59	Neutropenia (HP:0001875)	1.93587911
60	Meckel diverticulum (HP:0002245)	1.93571200
61	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.93325571
62	Hypoplasia of the uterus (HP:0000013)	1.92661258
63	Cerebral edema (HP:0002181)	1.92581730
64	Pigmentary retinal degeneration (HP:0001146)	1.92521902
65	Increased hepatocellular lipid droplets (HP:0006565)	1.92407602
66	Bile duct proliferation (HP:0001408)	1.92112864
67	Abnormal biliary tract physiology (HP:0012439)	1.92112864
68	IgG deficiency (HP:0004315)	1.91564081
69	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.90783395
70	Abnormality of the ileum (HP:0001549)	1.89632480
71	Lipid accumulation in hepatocytes (HP:0006561)	1.89364114
72	Type 2 muscle fiber atrophy (HP:0003554)	1.89011773
73	Lethargy (HP:0001254)	1.87669691
74	Abnormality of the carotid arteries (HP:0005344)	1.87503002
75	Dicarboxylic aciduria (HP:0003215)	1.87008409
76	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.87008409
77	Metabolic acidosis (HP:0001942)	1.86711638
78	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.84008682
79	Severe combined immunodeficiency (HP:0004430)	1.83043709
80	Hepatic necrosis (HP:0002605)	1.82320935
81	Delayed CNS myelination (HP:0002188)	1.82317323
82	Hydroxyprolinuria (HP:0003080)	1.80500180
83	Abnormality of proline metabolism (HP:0010907)	1.80500180
84	Ectopic kidney (HP:0000086)	1.79754203
85	Poor speech (HP:0002465)	1.79478798
86	Aplasia/hypoplasia of the uterus (HP:0008684)	1.79311657
87	Supernumerary spleens (HP:0009799)	1.78896145
88	Generalized aminoaciduria (HP:0002909)	1.77415764
89	Hypoplasia of the fovea (HP:0007750)	1.77029925
90	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.77029925
91	Hypomagnesemia (HP:0002917)	1.76783791
92	Colon cancer (HP:0003003)	1.76219327
93	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.76148184
94	Hypoplastic left heart (HP:0004383)	1.75146071
95	Abnormality of midbrain morphology (HP:0002418)	1.72269387
96	Molar tooth sign on MRI (HP:0002419)	1.72269387
97	Ketoacidosis (HP:0001993)	1.72213982
98	Renal Fanconi syndrome (HP:0001994)	1.72105450
99	Reduced subcutaneous adipose tissue (HP:0003758)	1.71647560
100	Clubbing of toes (HP:0100760)	1.70939541

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	3.78161795
2	TLK1	3.21789881
3	FRK	2.93246139
4	MAP4K2	2.68522976
5	EIF2AK3	2.45520943
6	ZAK	2.37079364
7	ADRBK2	2.30403577
8	BUB1	2.16856961
9	NUAK1	2.13226811
10	TSSK6	2.09391493
11	VRK1	1.92703457
12	MST4	1.91441217
13	BCR	1.90174584
14	BMPR1B	1.85293736
15	BCKDK	1.84781390
16	TESK2	1.80613712
17	NEK1	1.62816801
18	PLK3	1.58736416
19	TRIM28	1.57510895
20	GRK1	1.53865157
21	TXK	1.49992843
22	CDK9	1.45949508
23	MAP4K1	1.42326952
24	WNK3	1.41003244
25	PDK2	1.37645993
26	MAP3K13	1.37622129
27	BRSK2	1.35349451
28	TAF1	1.27012973
29	CSNK1G3	1.24597025
30	FES	1.24360903
31	DYRK2	1.23543525
32	MAP2K3	1.15747042
33	EIF2AK2	1.13916530
34	CSNK1G2	1.12817123
35	ATR	1.12248721
36	DAPK2	1.07529823
37	ADRBK1	1.06369747
38	CSNK1A1L	1.05349741
39	MAP3K12	1.04260639
40	OXSR1	1.03599819
41	LMTK2	1.03515734
42	KDR	1.02821324
43	FGR	1.01521983
44	PLK4	1.00671542
45	TGFBR1	1.00227202
46	CDK8	1.00097377
47	SRPK1	0.99478167
48	MAP3K3	0.97604506
49	PLK2	0.97020119
50	IKBKB	0.96117635
51	ACVR1B	0.95257761
52	CSNK1G1	0.94126418
53	TGFBR2	0.93439777
54	GRK7	0.92866116
55	STK16	0.91117478
56	PIK3CG	0.90130155
57	RPS6KB2	0.88761223
58	CAMKK2	0.88291129
59	GRK5	0.87854916
60	PINK1	0.80914879
61	PASK	0.80012268
62	MAPKAPK5	0.78530930
63	CDK19	0.73018564
64	PRKCE	0.70471251
65	RPS6KA4	0.68683813
66	INSRR	0.67908359
67	CSF1R	0.67023054
68	NEK9	0.65411688
69	TIE1	0.64346868
70	PRKCQ	0.64140688
71	JAK3	0.63309914
72	MKNK2	0.62279009
73	TTK	0.57760083
74	CCNB1	0.57609609
75	FGFR2	0.57105250
76	PLK1	0.55701825
77	RPS6KA5	0.55634771
78	PBK	0.53409521
79	SYK	0.51853005
80	CSNK1A1	0.47091527
81	NTRK2	0.45839499
82	PRKCI	0.44649428
83	PHKG2	0.43621902
84	PHKG1	0.43621902
85	MAP3K14	0.43154727
86	BRSK1	0.42719499
87	LIMK1	0.41660327
88	MAPK13	0.41492463
89	AURKB	0.40679296
90	WNK4	0.40204746
91	DAPK1	0.39945898
92	ERBB4	0.38965480
93	MAP2K6	0.38313068
94	GRK6	0.37898398
95	STK10	0.37429555
96	PRKCA	0.37092797
97	AURKA	0.36763909
98	PRKCG	0.36743879
99	TBK1	0.34840120
100	EPHA3	0.34467268

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	One carbon pool by folate_Homo sapiens_hsa00670	3.14808372
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.00970571
3	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.76276697
4	Non-homologous end-joining_Homo sapiens_hsa03450	2.70435337
5	Proteasome_Homo sapiens_hsa03050	2.39811344
6	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.27005520
7	Protein export_Homo sapiens_hsa03060	2.24186558
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.18030386
9	RNA polymerase_Homo sapiens_hsa03020	2.15998106
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.01691990
11	Propanoate metabolism_Homo sapiens_hsa00640	1.99953382
12	Sulfur metabolism_Homo sapiens_hsa00920	1.94862770
13	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.78112708
14	Fanconi anemia pathway_Homo sapiens_hsa03460	1.76789659
15	Selenocompound metabolism_Homo sapiens_hsa00450	1.72674821
16	Graft-versus-host disease_Homo sapiens_hsa05332	1.71578561
17	Fatty acid elongation_Homo sapiens_hsa00062	1.67349014
18	Antigen processing and presentation_Homo sapiens_hsa04612	1.53790436
19	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.53403357
20	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.52959734
21	RNA degradation_Homo sapiens_hsa03018	1.50676671
22	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.49455842
23	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.47093718
24	Basal transcription factors_Homo sapiens_hsa03022	1.43451866
25	Asthma_Homo sapiens_hsa05310	1.42872042
26	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.38039043
27	Collecting duct acid secretion_Homo sapiens_hsa04966	1.37057032
28	Parkinsons disease_Homo sapiens_hsa05012	1.36952517
29	Mismatch repair_Homo sapiens_hsa03430	1.36790846
30	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.35719495
31	Type I diabetes mellitus_Homo sapiens_hsa04940	1.32653936
32	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.30500103
33	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.30242297
34	Tryptophan metabolism_Homo sapiens_hsa00380	1.29206499
35	Allograft rejection_Homo sapiens_hsa05330	1.28074243
36	Nitrogen metabolism_Homo sapiens_hsa00910	1.26450881
37	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.25719390
38	Phototransduction_Homo sapiens_hsa04744	1.25652984
39	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.24275211
40	Homologous recombination_Homo sapiens_hsa03440	1.23349727
41	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.22748318
42	Peroxisome_Homo sapiens_hsa04146	1.16520389
43	Primary immunodeficiency_Homo sapiens_hsa05340	1.12888751
44	Nucleotide excision repair_Homo sapiens_hsa03420	1.11052877
45	Retinol metabolism_Homo sapiens_hsa00830	1.07526136
46	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.06784311
47	Regulation of autophagy_Homo sapiens_hsa04140	1.05564506
48	Purine metabolism_Homo sapiens_hsa00230	1.03621328
49	RNA transport_Homo sapiens_hsa03013	1.02749246
50	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.01945469
51	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.01580318
52	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.00455013
53	Rheumatoid arthritis_Homo sapiens_hsa05323	1.00196912
54	Linoleic acid metabolism_Homo sapiens_hsa00591	0.99913959
55	Pyrimidine metabolism_Homo sapiens_hsa00240	0.90548613
56	Butanoate metabolism_Homo sapiens_hsa00650	0.89752635
57	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.89435586
58	Caffeine metabolism_Homo sapiens_hsa00232	0.86582249
59	DNA replication_Homo sapiens_hsa03030	0.85355803
60	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.83173550
61	Base excision repair_Homo sapiens_hsa03410	0.82936167
62	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.82846855
63	Spliceosome_Homo sapiens_hsa03040	0.79596420
64	Chemical carcinogenesis_Homo sapiens_hsa05204	0.79571359
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.79234265
66	Olfactory transduction_Homo sapiens_hsa04740	0.79225115
67	Steroid biosynthesis_Homo sapiens_hsa00100	0.77380319
68	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.77195736
69	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.77064677
70	Glutathione metabolism_Homo sapiens_hsa00480	0.74085516
71	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.73282697
72	Nicotine addiction_Homo sapiens_hsa05033	0.72260004
73	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.71559634
74	Metabolic pathways_Homo sapiens_hsa01100	0.71557954
75	Sulfur relay system_Homo sapiens_hsa04122	0.71522286
76	Huntingtons disease_Homo sapiens_hsa05016	0.70501987
77	Ether lipid metabolism_Homo sapiens_hsa00565	0.70038644
78	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.69674374
79	Alzheimers disease_Homo sapiens_hsa05010	0.68986586
80	Fat digestion and absorption_Homo sapiens_hsa04975	0.68149652
81	Arginine biosynthesis_Homo sapiens_hsa00220	0.65650431
82	Morphine addiction_Homo sapiens_hsa05032	0.64808746
83	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.63514910
84	beta-Alanine metabolism_Homo sapiens_hsa00410	0.63112194
85	Carbon metabolism_Homo sapiens_hsa01200	0.61936061
86	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.59740708
87	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.58733222
88	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.58110335
89	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.56723288
90	Tyrosine metabolism_Homo sapiens_hsa00350	0.56275905
91	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.55929157
92	GABAergic synapse_Homo sapiens_hsa04727	0.54252092
93	Arginine and proline metabolism_Homo sapiens_hsa00330	0.52523664
94	Phenylalanine metabolism_Homo sapiens_hsa00360	0.49635508
95	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.49597278
96	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.48545811
97	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.44099777
98	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.43444563
99	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.42512163
100	Fatty acid metabolism_Homo sapiens_hsa01212	0.42038483

XRCC6P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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