XRN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)5.36191143
2nuclear pore complex assembly (GO:0051292)4.56383016
3nuclear pore organization (GO:0006999)4.50381965
4ribosome assembly (GO:0042255)4.40862252
5DNA unwinding involved in DNA replication (GO:0006268)4.13677512
6establishment of viral latency (GO:0019043)3.94061248
7ribosomal small subunit assembly (GO:0000028)3.92990387
8non-recombinational repair (GO:0000726)3.87062274
9double-strand break repair via nonhomologous end joining (GO:0006303)3.87062274
10DNA strand elongation involved in DNA replication (GO:0006271)3.65262614
11protein localization to kinetochore (GO:0034501)3.64719195
12mitotic nuclear envelope disassembly (GO:0007077)3.64283658
13DNA ligation (GO:0006266)3.62912936
14kinetochore organization (GO:0051383)3.59196710
15pore complex assembly (GO:0046931)3.57886201
16mitotic recombination (GO:0006312)3.56673173
17mitotic sister chromatid cohesion (GO:0007064)3.55755713
18telomere maintenance via semi-conservative replication (GO:0032201)3.55022987
19telomere maintenance via recombination (GO:0000722)3.51014894
20meiotic chromosome segregation (GO:0045132)3.49487429
21DNA strand elongation (GO:0022616)3.48129531
22regulation of centriole replication (GO:0046599)3.47290475
23negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.46646066
24mitotic chromosome condensation (GO:0007076)3.44475802
25regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.44067441
26DNA replication initiation (GO:0006270)3.43096843
27membrane disassembly (GO:0030397)3.40021681
28nuclear envelope disassembly (GO:0051081)3.40021681
29formation of translation preinitiation complex (GO:0001731)3.39847820
30chromatin remodeling at centromere (GO:0031055)3.38667282
31CENP-A containing nucleosome assembly (GO:0034080)3.36294981
32maturation of SSU-rRNA (GO:0030490)3.33192385
33regulation of sister chromatid segregation (GO:0033045)3.26877155
34regulation of mitotic sister chromatid separation (GO:0010965)3.26877155
35regulation of mitotic sister chromatid segregation (GO:0033047)3.26877155
36pre-miRNA processing (GO:0031054)3.19447769
37negative regulation of DNA repair (GO:0045738)3.18772910
38mitotic metaphase plate congression (GO:0007080)3.17901792
39DNA replication-independent nucleosome assembly (GO:0006336)3.15586576
40DNA replication-independent nucleosome organization (GO:0034724)3.15586576
41DNA geometric change (GO:0032392)3.14444271
42DNA duplex unwinding (GO:0032508)3.12744078
43DNA replication checkpoint (GO:0000076)3.12338929
44negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.10689331
45DNA topological change (GO:0006265)3.09425255
46regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.09335395
47attachment of spindle microtubules to kinetochore (GO:0008608)3.08760442
48protein localization to chromosome, centromeric region (GO:0071459)3.07953647
49response to X-ray (GO:0010165)3.06180961
50metaphase plate congression (GO:0051310)3.04985767
51nucleotide-excision repair, DNA gap filling (GO:0006297)3.04024083
52histone mRNA metabolic process (GO:0008334)3.03761318
53anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.02626903
54establishment of chromosome localization (GO:0051303)3.01539457
55telomere maintenance via telomere lengthening (GO:0010833)3.01395319
56proteasome assembly (GO:0043248)3.01373696
57viral mRNA export from host cell nucleus (GO:0046784)2.98425322
58spliceosomal snRNP assembly (GO:0000387)2.97419407
59DNA damage response, detection of DNA damage (GO:0042769)2.96303954
60cullin deneddylation (GO:0010388)2.95380347
61regulation of spindle organization (GO:0090224)2.95252652
62DNA replication-dependent nucleosome organization (GO:0034723)2.92597653
63DNA replication-dependent nucleosome assembly (GO:0006335)2.92597653
64IMP biosynthetic process (GO:0006188)2.91440625
65tRNA aminoacylation for protein translation (GO:0006418)2.88965096
66heterochromatin organization (GO:0070828)2.88002035
67sister chromatid segregation (GO:0000819)2.87736570
68tRNA aminoacylation (GO:0043039)2.87022757
69amino acid activation (GO:0043038)2.87022757
70positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.84643113
71telomere maintenance (GO:0000723)2.83628829
72positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.83110613
73positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.83110613
74positive regulation of mitotic sister chromatid separation (GO:1901970)2.83110613
75kinetochore assembly (GO:0051382)2.83081061
76regulation of translational fidelity (GO:0006450)2.82939493
77mitotic G2/M transition checkpoint (GO:0044818)2.82884425
78negative regulation of ligase activity (GO:0051352)2.82547198
79negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.82547198
80telomere organization (GO:0032200)2.79742893
81mitotic sister chromatid segregation (GO:0000070)2.79011464
82histone exchange (GO:0043486)2.76382683
83nucleobase biosynthetic process (GO:0046112)2.76103781
84regulation of DNA endoreduplication (GO:0032875)2.75904770
85negative regulation of DNA-dependent DNA replication (GO:2000104)2.72908862
86DNA conformation change (GO:0071103)2.71613779
87regulation of mitotic spindle organization (GO:0060236)2.70368466
88somatic diversification of immune receptors via somatic mutation (GO:0002566)2.69436531
89somatic hypermutation of immunoglobulin genes (GO:0016446)2.69436531
90DNA double-strand break processing (GO:0000729)2.67815547
91positive regulation of gamma-delta T cell activation (GO:0046645)2.66758622
92chromatin assembly or disassembly (GO:0006333)2.66047838
93regulation of histone H3-K9 methylation (GO:0051570)2.65671546
94mismatch repair (GO:0006298)2.64381540
95folic acid-containing compound biosynthetic process (GO:0009396)2.64140168
96maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.63633561
97regulation of nuclear cell cycle DNA replication (GO:0033262)2.63228775
98postreplication repair (GO:0006301)2.61438352
99regulation of double-strand break repair via homologous recombination (GO:0010569)2.60919108
100regulation of mitotic metaphase/anaphase transition (GO:0030071)2.60265856
101regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.60051894
102spindle checkpoint (GO:0031577)2.59673976
103positive regulation of chromosome segregation (GO:0051984)2.59063676
104viral transcription (GO:0019083)2.58772295
105regulation of helicase activity (GO:0051095)2.58606462
106ATP-dependent chromatin remodeling (GO:0043044)2.58058633
107ribosomal large subunit biogenesis (GO:0042273)2.57883460
108translational termination (GO:0006415)2.57148408
109regulation of sister chromatid cohesion (GO:0007063)2.56937104
110IMP metabolic process (GO:0046040)2.56802419
111purine nucleobase biosynthetic process (GO:0009113)2.54920677
112regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.54243197
113spindle assembly checkpoint (GO:0071173)2.54076426
114chromosome segregation (GO:0007059)2.51540049
115negative regulation of RNA splicing (GO:0033119)2.50883735
116nuclear envelope organization (GO:0006998)2.50545491
117negative regulation of mitotic sister chromatid separation (GO:2000816)2.50514050
118negative regulation of mitotic sister chromatid segregation (GO:0033048)2.50514050
119negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.50514050
120negative regulation of sister chromatid segregation (GO:0033046)2.50514050
121ribosomal small subunit biogenesis (GO:0042274)2.50075430
122negative regulation of chromosome segregation (GO:0051985)2.49976916
123negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.49743108
124regulation of chromosome segregation (GO:0051983)2.49423969
125regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.49380369
126mitotic spindle checkpoint (GO:0071174)2.48440334
127mitotic spindle assembly checkpoint (GO:0007094)2.48071735
128translesion synthesis (GO:0019985)2.47609678
129chromatin assembly (GO:0031497)2.46977285
130ribonucleoprotein complex biogenesis (GO:0022613)2.46393144
131protein localization to chromosome (GO:0034502)2.46049586
132replication fork processing (GO:0031297)2.45185422

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.32636691
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.08248141
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.45448162
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.11174812
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.05914749
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.69767998
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.49719048
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.36538728
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.33745981
10NELFA_20434984_ChIP-Seq_ESCs_Mouse2.27445793
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.26890943
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.26464620
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.26125027
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.20028694
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.15592863
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.12650621
17ELK1_19687146_ChIP-ChIP_HELA_Human2.12213008
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.11051411
19VDR_23849224_ChIP-Seq_CD4+_Human2.04031077
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.01890886
21AR_21909140_ChIP-Seq_LNCAP_Human2.00913487
22E2F7_22180533_ChIP-Seq_HELA_Human10.1158677
23* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.96764315
24* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.91112790
25* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.89792117
26* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.88987708
27IRF8_21731497_ChIP-ChIP_J774_Mouse1.88265053
28ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.86460829
29* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85746133
30MYC_22102868_ChIP-Seq_BL_Human1.84600584
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81524914
32XRN2_22483619_ChIP-Seq_HELA_Human1.78562036
33FOXP3_21729870_ChIP-Seq_TREG_Human1.77906635
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75409725
35* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72309727
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.72101204
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.71043173
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.70545762
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.67978568
40PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.66970832
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.59155134
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58891342
43* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58880387
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.58068280
45* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.56823805
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.55852467
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55743913
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53293806
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.52931526
50DCP1A_22483619_ChIP-Seq_HELA_Human1.48492731
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44188096
52STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.43031961
53* TTF2_22483619_ChIP-Seq_HELA_Human1.42392776
54* SPI1_23547873_ChIP-Seq_NB4_Human1.42345081
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41548805
56CIITA_25753668_ChIP-Seq_RAJI_Human1.38389050
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37191632
58MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.37099662
59* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35775873
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.35564965
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35134459
62MYB_26560356_Chip-Seq_TH2_Human1.34757649
63STAT4_19710469_ChIP-ChIP_TH1__Mouse1.34430090
64* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.32723048
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32358778
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30005863
67SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.29834653
68* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25568703
69* GABP_19822575_ChIP-Seq_HepG2_Human1.24856908
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23945595
71MYB_21317192_ChIP-Seq_ERMYB_Mouse1.22015652
72NANOG_16153702_ChIP-ChIP_HESCs_Human1.21958462
73MYB_26560356_Chip-Seq_TH1_Human1.21858653
74KDM5A_27292631_Chip-Seq_BREAST_Human1.20151735
75* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19058484
76FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17479591
77IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16525798
78* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15527632
79SOX17_20123909_ChIP-Seq_XEN_Mouse1.15162021
80TFEB_21752829_ChIP-Seq_HELA_Human1.15044578
81HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13210967
82* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11794431
83KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08921248
84KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08921248
85KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08921248
86EWS_26573619_Chip-Seq_HEK293_Human1.08804964
87HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06935207
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06806059
89SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06630244
90* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05768037
91NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03496818
92ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.02308627
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00415229
94SOX2_16153702_ChIP-ChIP_HESCs_Human0.99990583
95* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.98394100
96NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98124299
97POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96931005
98IRF8_27001747_Chip-Seq_BMDM_Mouse0.96601944
99VDR_21846776_ChIP-Seq_THP-1_Human0.96446200
100E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95968126
101MAF_26560356_Chip-Seq_TH1_Human0.95964902
102HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95237417
103YY1_21170310_ChIP-Seq_MESCs_Mouse0.94647306
104UTX_26944678_Chip-Seq_JUKART_Human0.94533935
105THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93471619
106ELK1_22589737_ChIP-Seq_MCF10A_Human0.93136916
107FLI1_27457419_Chip-Seq_LIVER_Mouse0.92804426
108* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92196824
109NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91892043
110PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91721643
111FUS_26573619_Chip-Seq_HEK293_Human0.90513578
112E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.88794187
113RUNX1_22412390_ChIP-Seq_EML_Mouse0.88072500
114CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87090727
115MYC_18940864_ChIP-ChIP_HL60_Human0.86786197
116SCL_19346495_ChIP-Seq_HPC-7_Human0.86057826
117CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.84973738
118STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84612977
119SRF_21415370_ChIP-Seq_HL-1_Mouse0.84550774
120* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84488963
121SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.84222133
122* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84074650
123KLF4_18555785_ChIP-Seq_MESCs_Mouse0.80941145
124SOX2_18555785_ChIP-Seq_MESCs_Mouse0.80628404
125STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.80474428
126* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.80327310
127* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.79907054
128ELF5_23300383_ChIP-Seq_T47D_Human0.79199116
129NANOG_21062744_ChIP-ChIP_HESCs_Human0.76411171
130DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.75890265
131* NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.73388790

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.81916167
2MP0008057_abnormal_DNA_replication3.76564110
3MP0003693_abnormal_embryo_hatching3.31210405
4MP0003077_abnormal_cell_cycle3.09604912
5MP0004957_abnormal_blastocyst_morpholog3.05573486
6MP0003111_abnormal_nucleus_morphology2.96483873
7MP0002396_abnormal_hematopoietic_system2.87483787
8MP0008058_abnormal_DNA_repair2.83713035
9MP0008007_abnormal_cellular_replicative2.57631723
10MP0001835_abnormal_antigen_presentation2.44055884
11MP0010352_gastrointestinal_tract_polyps2.41056008
12MP0009697_abnormal_copulation2.24993635
13MP0003763_abnormal_thymus_physiology2.22610045
14MP0008877_abnormal_DNA_methylation2.22100442
15MP0005671_abnormal_response_to1.95904778
16MP0004808_abnormal_hematopoietic_stem1.94572843
17MP0003718_maternal_effect1.86640078
18MP0002006_tumorigenesis1.85859900
19MP0001800_abnormal_humoral_immune1.79499796
20MP0002398_abnormal_bone_marrow1.78227987
21MP0010307_abnormal_tumor_latency1.77405025
22MP0000350_abnormal_cell_proliferation1.75327655
23MP0008932_abnormal_embryonic_tissue1.74377767
24MP0009333_abnormal_splenocyte_physiolog1.71168559
25MP0002452_abnormal_antigen_presenting1.68248469
26MP0009785_altered_susceptibility_to1.67039130
27MP0000685_abnormal_immune_system1.65945904
28MP0000490_abnormal_crypts_of1.65927877
29MP0001730_embryonic_growth_arrest1.64507855
30MP0003806_abnormal_nucleotide_metabolis1.63654534
31MP0002420_abnormal_adaptive_immunity1.58729359
32MP0000703_abnormal_thymus_morphology1.57549639
33MP0001819_abnormal_immune_cell1.57547290
34MP0003937_abnormal_limbs/digits/tail_de1.55312218
35MP0006292_abnormal_olfactory_placode1.54348980
36MP0009672_abnormal_birth_weight1.52719321
37MP0001545_abnormal_hematopoietic_system1.52673036
38MP0005397_hematopoietic_system_phenotyp1.52673036
39MP0005000_abnormal_immune_tolerance1.52240439
40MP0002166_altered_tumor_susceptibility1.49336608
41MP0002233_abnormal_nose_morphology1.47871609
42MP0002723_abnormal_immune_serum1.47309931
43MP0002722_abnormal_immune_system1.46681554
44MP0003786_premature_aging1.46262600
45MP0000858_altered_metastatic_potential1.44477665
46MP0002938_white_spotting1.43499561
47MP0000689_abnormal_spleen_morphology1.43135892
48MP0000716_abnormal_immune_system1.42794976
49MP0003448_altered_tumor_morphology1.39547806
50MP0005076_abnormal_cell_differentiation1.39376608
51MP0005408_hypopigmentation1.39172928
52MP0002148_abnormal_hypersensitivity_rea1.38998498
53MP0002019_abnormal_tumor_incidence1.37085994
54MP0003436_decreased_susceptibility_to1.37010307
55MP0003221_abnormal_cardiomyocyte_apopto1.35608281
56MP0005387_immune_system_phenotype1.35075863
57MP0001790_abnormal_immune_system1.35075863
58MP0002877_abnormal_melanocyte_morpholog1.34884378
59MP0002697_abnormal_eye_size1.34168861
60MP0008789_abnormal_olfactory_epithelium1.32818938
61MP0002429_abnormal_blood_cell1.32666019
62MP0000569_abnormal_digit_pigmentation1.30804798
63MP0005025_abnormal_response_to1.28684694
64MP0003123_paternal_imprinting1.28609466
65MP0001529_abnormal_vocalization1.28318708
66MP0005380_embryogenesis_phenotype1.23483619
67MP0001672_abnormal_embryogenesis/_devel1.23483619
68MP0002405_respiratory_system_inflammati1.21709405
69MP0001697_abnormal_embryo_size1.20716084
70MP0006054_spinal_hemorrhage1.18375994
71MP0003121_genomic_imprinting1.18278462
72MP0004197_abnormal_fetal_growth/weight/1.18216604
73MP0010155_abnormal_intestine_physiology1.18008326
74MP0000313_abnormal_cell_death1.17329810
75MP0002086_abnormal_extraembryonic_tissu1.17155537
76MP0009703_decreased_birth_body1.17088337
77MP0003984_embryonic_growth_retardation1.14635368
78MP0002419_abnormal_innate_immunity1.14476115
79MP0001853_heart_inflammation1.12224943
80MP0002088_abnormal_embryonic_growth/wei1.11750017
81MP0009278_abnormal_bone_marrow1.11369759
82MP0001873_stomach_inflammation1.07655666
83MP0000358_abnormal_cell_content/1.07504500
84MP0001915_intracranial_hemorrhage1.05674719
85MP0002080_prenatal_lethality1.05082498
86MP0005075_abnormal_melanosome_morpholog1.02367462
87MP0010234_abnormal_vibrissa_follicle1.02266288
88MP0002085_abnormal_embryonic_tissue1.01370060
89MP0003890_abnormal_embryonic-extraembry1.00331960
90MP0002084_abnormal_developmental_patter0.98994085
91MP0003787_abnormal_imprinting0.97901228
92MP0006082_CNS_inflammation0.95203152
93MP0002111_abnormal_tail_morphology0.95121125
94MP0002009_preneoplasia0.94499316
95MP0003186_abnormal_redox_activity0.94068360
96MP0003385_abnormal_body_wall0.93982051
97MP0002102_abnormal_ear_morphology0.93074093
98MP0002751_abnormal_autonomic_nervous0.91849514
99MP0003300_gastrointestinal_ulcer0.91710668
100MP0009053_abnormal_anal_canal0.91394467
101MP0001293_anophthalmia0.91092370
102MP0006035_abnormal_mitochondrial_morpho0.89740008
103MP0001929_abnormal_gametogenesis0.88885605
104MP0005464_abnormal_platelet_physiology0.88705912
105MP0005023_abnormal_wound_healing0.88687693
106MP0003755_abnormal_palate_morphology0.86984934
107MP0005499_abnormal_olfactory_system0.85726321
108MP0005394_taste/olfaction_phenotype0.85726321
109MP0003315_abnormal_perineum_morphology0.84918749
110MP0002210_abnormal_sex_determination0.84713994
111MP0005384_cellular_phenotype0.83945333
112MP0003943_abnormal_hepatobiliary_system0.82603994
113MP0008260_abnormal_autophagy0.82436522
114MP0001845_abnormal_inflammatory_respons0.82408495
115MP0003567_abnormal_fetal_cardiomyocyte0.81951797
116MP0003935_abnormal_craniofacial_develop0.81845595
117MP0004947_skin_inflammation0.79612773
118MP0000653_abnormal_sex_gland0.79260083
119MP0005174_abnormal_tail_pigmentation0.78939743
120MP0003950_abnormal_plasma_membrane0.78433594
121MP0000627_abnormal_mammary_gland0.78427764
122MP0003122_maternal_imprinting0.77928577
123MP0005248_abnormal_Harderian_gland0.77771925
124MP0000432_abnormal_head_morphology0.77364605
125MP0001119_abnormal_female_reproductive0.76127119
126MP0002277_abnormal_respiratory_mucosa0.75756637
127MP0003566_abnormal_cell_adhesion0.74587316
128MP0003941_abnormal_skin_development0.74362253
129MP0003861_abnormal_nervous_system0.71863486
130MP0002132_abnormal_respiratory_system0.70892823
131MP0003119_abnormal_digestive_system0.70157880
132MP0003115_abnormal_respiratory_system0.69826743
133MP0000465_gastrointestinal_hemorrhage0.69759912
134MP0001188_hyperpigmentation0.69159886
135MP0004185_abnormal_adipocyte_glucose0.68746604
136MP0002933_joint_inflammation0.68375126
137MP0002254_reproductive_system_inflammat0.68342761
138MP0001145_abnormal_male_reproductive0.68222730
139MP0002095_abnormal_skin_pigmentation0.67878045
140MP0005621_abnormal_cell_physiology0.67371823
141MP0000428_abnormal_craniofacial_morphol0.66964891
142MP0001324_abnormal_eye_pigmentation0.66677039
143MP0000371_diluted_coat_color0.66105310
144MP0002092_abnormal_eye_morphology0.65862730
145MP0001881_abnormal_mammary_gland0.64213935
146MP0001286_abnormal_eye_development0.63092521
147MP0010030_abnormal_orbit_morphology0.63041938
148MP0001340_abnormal_eyelid_morphology0.62099445
149MP0003936_abnormal_reproductive_system0.61875562
150MP0001186_pigmentation_phenotype0.60369102

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)3.85919388
2Nephroblastoma (Wilms tumor) (HP:0002667)3.58832226
3Embryonal renal neoplasm (HP:0011794)3.40946082
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.34128522
5Birth length less than 3rd percentile (HP:0003561)3.20558323
6Reticulocytopenia (HP:0001896)3.19030618
7Volvulus (HP:0002580)3.18341268
8Abnormality of chromosome stability (HP:0003220)3.05909129
9Cortical dysplasia (HP:0002539)2.98253287
10Colon cancer (HP:0003003)2.92470947
11Multiple enchondromatosis (HP:0005701)2.88282817
12Agnosia (HP:0010524)2.88150901
13T lymphocytopenia (HP:0005403)2.82680527
14Thrombocytosis (HP:0001894)2.77841618
15Myelodysplasia (HP:0002863)2.76003623
16Abnormality of T cell number (HP:0011839)2.74010285
17Abnormality of the labia minora (HP:0012880)2.65673751
1811 pairs of ribs (HP:0000878)2.60836012
19Medulloblastoma (HP:0002885)2.52401898
20Papillary thyroid carcinoma (HP:0002895)2.52098563
21Recurrent viral infections (HP:0004429)2.49314377
22Abnormality of the preputium (HP:0100587)2.46748092
23Lymphoma (HP:0002665)2.46566980
24Abnormality of methionine metabolism (HP:0010901)2.45188479
25IgM deficiency (HP:0002850)2.43692097
26Abnormality of T cells (HP:0002843)2.42340763
27Meckel diverticulum (HP:0002245)2.42132509
28Microvesicular hepatic steatosis (HP:0001414)2.41567464
29Ectopic kidney (HP:0000086)2.40313805
30Abnormality of the fingertips (HP:0001211)2.39562334
31Facial cleft (HP:0002006)2.39513944
32Deviation of the thumb (HP:0009603)2.39360587
33Amaurosis fugax (HP:0100576)2.36187573
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.31833805
35Aplastic anemia (HP:0001915)2.31664468
36Abnormality of the anterior horn cell (HP:0006802)2.30240410
37Degeneration of anterior horn cells (HP:0002398)2.30240410
38Abnormality of the ileum (HP:0001549)2.29383447
39Selective tooth agenesis (HP:0001592)2.29163577
40Microglossia (HP:0000171)2.27778121
41Macrocytic anemia (HP:0001972)2.26993427
42IgG deficiency (HP:0004315)2.26470326
43Proximal placement of thumb (HP:0009623)2.24234757
44Triphalangeal thumb (HP:0001199)2.24089152
45Recurrent bronchitis (HP:0002837)2.23852448
46Stenosis of the external auditory canal (HP:0000402)2.23578624
47Ependymoma (HP:0002888)2.22833104
48Neoplasm of the colon (HP:0100273)2.22691215
49IgA deficiency (HP:0002720)2.17262113
50Myositis (HP:0100614)2.15986232
51Elevated erythrocyte sedimentation rate (HP:0003565)2.15982838
52Bifid tongue (HP:0010297)2.15059608
53Acute myeloid leukemia (HP:0004808)2.14777521
54Absent thumb (HP:0009777)2.14566366
55Combined immunodeficiency (HP:0005387)2.10792012
56Duodenal stenosis (HP:0100867)2.10055300
57Small intestinal stenosis (HP:0012848)2.10055300
58Clubbing of toes (HP:0100760)2.09980818
59Malignant gastrointestinal tract tumors (HP:0006749)2.09150365
60Gastrointestinal carcinoma (HP:0002672)2.09150365
61Patellar aplasia (HP:0006443)2.08893920
62Mediastinal lymphadenopathy (HP:0100721)2.06508919
63Choanal atresia (HP:0000453)2.01985701
64Progressive external ophthalmoplegia (HP:0000590)2.01772183
65Severe combined immunodeficiency (HP:0004430)2.01736792
66Spastic diplegia (HP:0001264)2.00971223
67Increased nuchal translucency (HP:0010880)2.00924820
68Basal cell carcinoma (HP:0002671)2.00469662
69Capillary hemangiomas (HP:0005306)1.99948648
70Biliary tract neoplasm (HP:0100574)1.99511974
71Horseshoe kidney (HP:0000085)1.98783271
72Increased hepatocellular lipid droplets (HP:0006565)1.98592673
73Bone marrow hypocellularity (HP:0005528)1.97065568
74Thyroid carcinoma (HP:0002890)1.96811589
75Recurrent abscess formation (HP:0002722)1.96400000
76Short 4th metacarpal (HP:0010044)1.96152588
77Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.96152588
78Spinal cord lesions (HP:0100561)1.95301339
79Syringomyelia (HP:0003396)1.95301339
80Increased serum pyruvate (HP:0003542)1.95034109
81Shoulder girdle muscle weakness (HP:0003547)1.94847468
82Abnormality of cells of the lymphoid lineage (HP:0012140)1.94790496
83Abnormality of glycolysis (HP:0004366)1.94372418
84Poikiloderma (HP:0001029)1.92504558
85Pancreatic islet-cell hyperplasia (HP:0004510)1.92075302
86Lymphopenia (HP:0001888)1.91822157
87Pallor (HP:0000980)1.90412248
88Uterine neoplasm (HP:0010784)1.89485582
89Abnormality of T cell physiology (HP:0011840)1.89182311
90Recurrent fungal infections (HP:0002841)1.88913383
91Absent frontal sinuses (HP:0002688)1.88464433
92Premature graying of hair (HP:0002216)1.88241666
93Irregular epiphyses (HP:0010582)1.88186029
94Aplasia/Hypoplasia of the patella (HP:0006498)1.88143624
95Deep philtrum (HP:0002002)1.86326335
96Megaloblastic anemia (HP:0001889)1.85603293
97Oral leukoplakia (HP:0002745)1.85499280
98Uterine leiomyosarcoma (HP:0002891)1.85154742
99Leiomyosarcoma (HP:0100243)1.85154742
100Abnormality of cells of the erythroid lineage (HP:0012130)1.85120332
101Abnormality of the prostate (HP:0008775)1.84731030
102Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.84682980
103Optic nerve coloboma (HP:0000588)1.83879235
104Abnormality of DNA repair (HP:0003254)1.83615125
105Cutaneous melanoma (HP:0012056)1.83606756
106Embryonal neoplasm (HP:0002898)1.83548999
107Abnormal lung lobation (HP:0002101)1.83081857
108Impulsivity (HP:0100710)1.82647746
109Transitional cell carcinoma of the bladder (HP:0006740)1.82189927
110Duplicated collecting system (HP:0000081)1.82066250
111Rough bone trabeculation (HP:0100670)1.81934290
112Carpal bone hypoplasia (HP:0001498)1.81704786
113Eosinophilia (HP:0001880)1.81675291
114Abnormal hair whorl (HP:0010721)1.81068648
115Rectal fistula (HP:0100590)1.80972529
116Rectovaginal fistula (HP:0000143)1.80972529
117Neoplasm of the adrenal cortex (HP:0100641)1.80246508
118Abnormality of the renal collecting system (HP:0004742)1.80059898
119Glioma (HP:0009733)1.78856423
120Cleft eyelid (HP:0000625)1.78772605
121Sloping forehead (HP:0000340)1.78552152
122Absent forearm bone (HP:0003953)1.78501301
123Aplasia involving forearm bones (HP:0009822)1.78501301
124Leukocytosis (HP:0001974)1.78386252
125Rhabdomyosarcoma (HP:0002859)1.78269403
126Absent radius (HP:0003974)1.77545915
127Breast hypoplasia (HP:0003187)1.77527630
128Abnormality of eosinophils (HP:0001879)1.76629482
129Gonadotropin excess (HP:0000837)1.75920050
130Cellular immunodeficiency (HP:0005374)1.75784234
131Thyroiditis (HP:0100646)1.74848340
132Blepharitis (HP:0000498)1.74050776
133Granulocytopenia (HP:0001913)1.73482103
134Abnormality of the duodenum (HP:0002246)1.73264164
135High pitched voice (HP:0001620)1.71496169
136Neoplasm of striated muscle (HP:0009728)1.70923742
137Sensory axonal neuropathy (HP:0003390)1.70323720
138Overlapping toe (HP:0001845)1.70215140
139Eczematoid dermatitis (HP:0000976)1.70126823
140Prominent metopic ridge (HP:0005487)1.69993441
141Orchitis (HP:0100796)1.69673922
142Abnormal number of erythroid precursors (HP:0012131)1.69365174
143Cafe-au-lait spot (HP:0000957)1.68381727
144Skull defect (HP:0001362)1.68222552
145Cellulitis (HP:0100658)1.67994651
146Atresia of the external auditory canal (HP:0000413)1.67870723
147Increased density of long bones (HP:0006392)1.67432652
148Prostate neoplasm (HP:0100787)1.67335074
149Pulmonary fibrosis (HP:0002206)1.67324196
150Abnormality of the carotid arteries (HP:0005344)1.67167516
151Neoplasm of the pancreas (HP:0002894)1.66929761
152Retrobulbar optic neuritis (HP:0100654)1.66608214
153Neuroblastic tumors (HP:0004376)1.65257997
154Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.65257997
155Neuroblastoma (HP:0003006)1.65257997
156Primitive neuroectodermal tumor (HP:0030065)1.65257997
157Aplasia/Hypoplasia of the sacrum (HP:0008517)1.65247083
158Abnormality of the astrocytes (HP:0100707)1.64522278
159Astrocytoma (HP:0009592)1.64522278
160Arteriovenous malformation (HP:0100026)1.64118696
161Pelvic girdle muscle weakness (HP:0003749)1.63942850
162Supernumerary spleens (HP:0009799)1.63633889

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.99069600
2VRK22.96106217
3WEE12.66034499
4TAF12.60649121
5ACVR1B2.45164430
6TXK2.44206973
7MAP4K12.39614164
8SRPK12.35504075
9TRIM282.29548279
10BUB12.22263593
11STK102.21902873
12MAP3K142.19018527
13EIF2AK12.05441637
14NEK21.98922294
15TSSK61.98599589
16MKNK11.94554173
17PASK1.86625291
18CDK121.85627715
19TGFBR11.81891484
20ATR1.77737363
21JAK31.77328625
22PLK41.65028494
23TTK1.64746301
24PNCK1.63435854
25PLK11.51775749
26AURKB1.51436326
27RPS6KB21.46663202
28MAP3K101.44829610
29PLK31.42580637
30RPS6KA41.37302326
31PBK1.36275255
32STK41.35390536
33PIM11.34094189
34BRSK21.33908651
35CDK41.32490557
36TNIK1.31238008
37CDK71.30412526
38BCR1.27542441
39MELK1.27412536
40MKNK21.26480620
41NEK91.24359886
42CHUK1.22710255
43VRK11.21678166
44CDK61.21335827
45TLK11.20804900
46ZAK1.20488750
47EIF2AK31.19785885
48BRD41.19508408
49CDK81.16342241
50EEF2K1.15845820
51CHEK21.14248378
52IRAK41.11751659
53FGFR11.11169705
54TYK21.10209686
55SMG11.09644004
56CHEK11.09425910
57ERBB41.08539383
58EIF2AK21.07319011
59STK241.05206313
60IKBKB1.01530368
61ZAP701.00240222
62ATM0.99343401
63TEC0.99097194
64NME20.97540567
65MAP3K80.97390322
66BMPR1B0.96743499
67MST40.95192053
68STK38L0.94555147
69NEK10.94438584
70ITK0.93360069
71WNK30.93352849
72NUAK10.92305634
73MAP3K120.90272368
74FGFR30.89243698
75BTK0.84722805
76IKBKE0.82577249
77KIT0.82228519
78LRRK20.81116490
79DYRK30.80715938
80CDK90.78984477
81FLT30.78317683
82PAK40.78078039
83BLK0.77973418
84* CDK20.75214514
85ERBB30.74669673
86CSF1R0.73857366
87PKN20.73664410
88DYRK20.73553773
89LCK0.73175923
90CCNB10.72566888
91GRK60.71883301
92CLK10.70175815
93TBK10.69675206
94CDK190.65660802
95MARK30.65385254
96CSK0.65324628
97NME10.64350329
98TRPM70.63166487
99STK30.61775355
100CAMK1G0.59517894
101CSNK1G10.59331706
102SYK0.59094051
103PIM20.58278705
104LATS10.57958810
105ALK0.56832373
106CDK10.56359812
107CSNK2A20.56322881
108CSNK1E0.55562378
109NLK0.54234836
110LYN0.54233163
111EPHA20.53456845
112TESK20.50630180
113CSNK2A10.50411376
114YES10.49771599
115AURKA0.48846842
116IRAK30.48414960
117TESK10.48380254
118CSNK1A1L0.48073498
119PDK20.45805810
120SCYL20.45729786
121SIK30.44382872
122BRSK10.42067521
123RPS6KA50.41410076
124JAK10.40805508
125STK160.39049716
126PRKDC0.37262114
127CDK30.36418547
128CSNK1G30.34665187
129CSNK1G20.29866357
130EGFR0.29745150
131RPS6KB10.28312886
132DAPK10.28038594
133FGR0.27160170
134CAMK1D0.26615698
135KSR10.24078948
136NEK60.22922196
137PRKACB0.21235507

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.89269418
2Mismatch repair_Homo sapiens_hsa034303.45626504
3* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.81203673
4Spliceosome_Homo sapiens_hsa030402.76883820
5Base excision repair_Homo sapiens_hsa034102.72553295
6RNA transport_Homo sapiens_hsa030132.50425407
7Homologous recombination_Homo sapiens_hsa034402.49933940
8Cell cycle_Homo sapiens_hsa041102.41560136
9Non-homologous end-joining_Homo sapiens_hsa034502.37220886
10Nucleotide excision repair_Homo sapiens_hsa034202.33116312
11One carbon pool by folate_Homo sapiens_hsa006702.25007444
12Ribosome_Homo sapiens_hsa030102.21943470
13Fanconi anemia pathway_Homo sapiens_hsa034601.98816527
14RNA polymerase_Homo sapiens_hsa030201.90209181
15Proteasome_Homo sapiens_hsa030501.87263272
16Primary immunodeficiency_Homo sapiens_hsa053401.83600484
17Graft-versus-host disease_Homo sapiens_hsa053321.82414440
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.75301955
19* RNA degradation_Homo sapiens_hsa030181.73674527
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.73482981
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.69255877
22Herpes simplex infection_Homo sapiens_hsa051681.68997786
23Antigen processing and presentation_Homo sapiens_hsa046121.66011296
24p53 signaling pathway_Homo sapiens_hsa041151.59790627
25mRNA surveillance pathway_Homo sapiens_hsa030151.59513495
26Measles_Homo sapiens_hsa051621.59055179
27Pyrimidine metabolism_Homo sapiens_hsa002401.55369907
28Steroid biosynthesis_Homo sapiens_hsa001001.51606327
29Basal transcription factors_Homo sapiens_hsa030221.51558310
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46552875
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.36840166
32Leishmaniasis_Homo sapiens_hsa051401.36702861
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.35513998
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.33538380
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.33172268
36Epstein-Barr virus infection_Homo sapiens_hsa051691.32489249
37Systemic lupus erythematosus_Homo sapiens_hsa053221.30959052
38Allograft rejection_Homo sapiens_hsa053301.29955333
39Legionellosis_Homo sapiens_hsa051341.26045117
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25857155
41Viral carcinogenesis_Homo sapiens_hsa052031.24884029
42Propanoate metabolism_Homo sapiens_hsa006401.23394022
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19598413
44Pyruvate metabolism_Homo sapiens_hsa006201.11501574
45HTLV-I infection_Homo sapiens_hsa051661.06999233
46Influenza A_Homo sapiens_hsa051641.05736481
47Viral myocarditis_Homo sapiens_hsa054161.05730011
48Hematopoietic cell lineage_Homo sapiens_hsa046401.04534146
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01554841
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00730321
51T cell receptor signaling pathway_Homo sapiens_hsa046601.00512809
52Hepatitis B_Homo sapiens_hsa051611.00112220
53Small cell lung cancer_Homo sapiens_hsa052220.99086396
54Biosynthesis of amino acids_Homo sapiens_hsa012300.97077521
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96628437
56Apoptosis_Homo sapiens_hsa042100.95162061
57B cell receptor signaling pathway_Homo sapiens_hsa046620.93256053
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93214934
59MicroRNAs in cancer_Homo sapiens_hsa052060.91179669
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90931852
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88815540
62Shigellosis_Homo sapiens_hsa051310.86939219
63Type I diabetes mellitus_Homo sapiens_hsa049400.85895489
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85025243
65Huntingtons disease_Homo sapiens_hsa050160.85024916
66Autoimmune thyroid disease_Homo sapiens_hsa053200.84913178
67Toxoplasmosis_Homo sapiens_hsa051450.83452857
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83449277
69Carbon metabolism_Homo sapiens_hsa012000.83065848
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.82815087
71Osteoclast differentiation_Homo sapiens_hsa043800.82320977
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81558079
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81107685
74Chronic myeloid leukemia_Homo sapiens_hsa052200.80531463
75Parkinsons disease_Homo sapiens_hsa050120.78807511
76Pancreatic cancer_Homo sapiens_hsa052120.74064887
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.73386126
78TNF signaling pathway_Homo sapiens_hsa046680.72801974
79Lysine degradation_Homo sapiens_hsa003100.70544182
80Oxidative phosphorylation_Homo sapiens_hsa001900.68115102
81Colorectal cancer_Homo sapiens_hsa052100.67651465
82Purine metabolism_Homo sapiens_hsa002300.66724866
83Wnt signaling pathway_Homo sapiens_hsa043100.66475299
84Folate biosynthesis_Homo sapiens_hsa007900.63996246
85N-Glycan biosynthesis_Homo sapiens_hsa005100.63913460
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.60783326
87Glutathione metabolism_Homo sapiens_hsa004800.60482728
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58718994
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58098325
90Vitamin B6 metabolism_Homo sapiens_hsa007500.57504161
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57257366
92Thyroid cancer_Homo sapiens_hsa052160.56761280
93Malaria_Homo sapiens_hsa051440.56643369
94TGF-beta signaling pathway_Homo sapiens_hsa043500.55743126
95Basal cell carcinoma_Homo sapiens_hsa052170.54880847
96Pertussis_Homo sapiens_hsa051330.54473271
97Acute myeloid leukemia_Homo sapiens_hsa052210.54295839
98Pentose phosphate pathway_Homo sapiens_hsa000300.54112282
99Adherens junction_Homo sapiens_hsa045200.53466515
100Tuberculosis_Homo sapiens_hsa051520.52989606
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52368931
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51577810
103Hepatitis C_Homo sapiens_hsa051600.49064980
104Oocyte meiosis_Homo sapiens_hsa041140.49023290
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47780203
106Selenocompound metabolism_Homo sapiens_hsa004500.47361726
107Fatty acid elongation_Homo sapiens_hsa000620.46420858
108Prostate cancer_Homo sapiens_hsa052150.46047537
109Notch signaling pathway_Homo sapiens_hsa043300.45792110
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.45438445
111Asthma_Homo sapiens_hsa053100.45384524
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44761586
113Salmonella infection_Homo sapiens_hsa051320.44393920
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43684573
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42979042
116Pathways in cancer_Homo sapiens_hsa052000.40716900
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39469633
118Chemokine signaling pathway_Homo sapiens_hsa040620.39251120
119Non-small cell lung cancer_Homo sapiens_hsa052230.38465708
120HIF-1 signaling pathway_Homo sapiens_hsa040660.37702252
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36763554
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35529190
123Platelet activation_Homo sapiens_hsa046110.35310311
124Fatty acid metabolism_Homo sapiens_hsa012120.33474889
125Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.33389252
126FoxO signaling pathway_Homo sapiens_hsa040680.32318000
127Metabolic pathways_Homo sapiens_hsa011000.31748947
128Hedgehog signaling pathway_Homo sapiens_hsa043400.31447916
129Proteoglycans in cancer_Homo sapiens_hsa052050.29630184
130African trypanosomiasis_Homo sapiens_hsa051430.29056956
131Protein export_Homo sapiens_hsa030600.28472699
132Hippo signaling pathway_Homo sapiens_hsa043900.28038116
133Alcoholism_Homo sapiens_hsa050340.26991617
134Sulfur metabolism_Homo sapiens_hsa009200.26650232
135Endometrial cancer_Homo sapiens_hsa052130.26599970
136Renin-angiotensin system_Homo sapiens_hsa046140.25466737
137Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.25263294
138Alzheimers disease_Homo sapiens_hsa050100.21197670
139Bladder cancer_Homo sapiens_hsa052190.18926111
140Tight junction_Homo sapiens_hsa045300.18338231
141Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17564908
142Fatty acid biosynthesis_Homo sapiens_hsa000610.17198152
143Drug metabolism - other enzymes_Homo sapiens_hsa009830.17005032
144Melanoma_Homo sapiens_hsa052180.16043504
145Regulation of autophagy_Homo sapiens_hsa041400.13551840
146Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.13259584

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »