XYLT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes a xylosyltransferase enzyme. The encoded protein catalyzes transfer of UDP-xylose to serine residues of an acceptor protein substrate. This transfer reaction is necessary for biosynthesis of glycosaminoglycan chains. Mutations in this gene have been associated with increased severity of pseudoxanthoma elasticum. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)4.83425802
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.22683504
3neuron cell-cell adhesion (GO:0007158)4.13958697
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.13047517
5L-amino acid import (GO:0043092)4.09733214
6negative regulation of erythrocyte differentiation (GO:0045647)4.06251143
7positive regulation of gamma-delta T cell activation (GO:0046645)3.94843218
8ionotropic glutamate receptor signaling pathway (GO:0035235)3.85533977
9regulation of glutamate receptor signaling pathway (GO:1900449)3.72953219
10chondrocyte development (GO:0002063)3.70229643
11amino acid import (GO:0043090)3.66871509
12vocalization behavior (GO:0071625)3.66003062
13response to muramyl dipeptide (GO:0032495)3.61489073
14regulation of short-term neuronal synaptic plasticity (GO:0048172)3.49990858
15exploration behavior (GO:0035640)3.39958293
16glutamate receptor signaling pathway (GO:0007215)3.38498854
17regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.37274825
18barbed-end actin filament capping (GO:0051016)3.33807846
19protein localization to synapse (GO:0035418)3.26830707
20hypotonic response (GO:0006971)3.24274364
21cellular potassium ion homeostasis (GO:0030007)3.23386279
22endodermal cell differentiation (GO:0035987)3.21316624
23chondroitin sulfate catabolic process (GO:0030207)3.20864314
24cell aggregation (GO:0098743)3.19715131
25cartilage condensation (GO:0001502)3.19715131
26limb bud formation (GO:0060174)3.16635354
27long-term synaptic potentiation (GO:0060291)3.14681598
28negative regulation of synaptic transmission, GABAergic (GO:0032229)3.10677463
29dermatan sulfate biosynthetic process (GO:0030208)3.10197276
30stress fiber assembly (GO:0043149)3.09827482
31synaptic transmission, glutamatergic (GO:0035249)3.06992598
32synaptic vesicle exocytosis (GO:0016079)3.05499087
33presynaptic membrane assembly (GO:0097105)3.04602704
34postsynaptic membrane organization (GO:0001941)3.03543282
35regulation of synaptic vesicle exocytosis (GO:2000300)3.02197690
36dermatan sulfate metabolic process (GO:0030205)3.00102569
37positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.99703292
38response to peptidoglycan (GO:0032494)2.96354632
39synaptic vesicle maturation (GO:0016188)2.95111956
40mannose metabolic process (GO:0006013)2.94473898
41* chondroitin sulfate biosynthetic process (GO:0030206)2.94224532
42neurotransmitter-gated ion channel clustering (GO:0072578)2.94054009
43long-term memory (GO:0007616)2.91822319
44positive regulation of B cell differentiation (GO:0045579)2.91497506
45regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.89827927
46collagen fibril organization (GO:0030199)2.89708281
47negative regulation of cell killing (GO:0031342)2.89493168
48negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.89493168
49synaptic vesicle docking involved in exocytosis (GO:0016081)2.89032822
50regulation of B cell differentiation (GO:0045577)2.87704298
51glutamate secretion (GO:0014047)2.86973675
52positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.86661292
53regulation of macrophage cytokine production (GO:0010935)2.85220561
54keratan sulfate catabolic process (GO:0042340)2.84292832
55protein localization to endosome (GO:0036010)2.82150579
56regulation of B cell receptor signaling pathway (GO:0050855)2.81275771
57negative thymic T cell selection (GO:0045060)2.79940974
58regulation of synaptic transmission, glutamatergic (GO:0051966)2.79709929
59regulation of excitatory postsynaptic membrane potential (GO:0060079)2.79353176
60phospholipid translocation (GO:0045332)2.79158280
61lipid translocation (GO:0034204)2.79158280
62positive regulation of blood vessel endothelial cell migration (GO:0043536)2.77144714
63protein heterotrimerization (GO:0070208)2.77133010
64cell migration involved in heart development (GO:0060973)2.76574992
65regulation of long-term neuronal synaptic plasticity (GO:0048169)2.76199759
66B cell receptor signaling pathway (GO:0050853)2.75790798
67innervation (GO:0060384)2.75644097
68regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.75529663
69regulation of gamma-delta T cell activation (GO:0046643)2.71385221
70negative T cell selection (GO:0043383)2.70954984
71neuron-neuron synaptic transmission (GO:0007270)2.69454541
72cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.68917746
73layer formation in cerebral cortex (GO:0021819)2.68759797
74extracellular matrix assembly (GO:0085029)2.68407856
75dendritic spine morphogenesis (GO:0060997)2.68228017
76cell-substrate junction assembly (GO:0007044)2.67868841
77regulation of postsynaptic membrane potential (GO:0060078)2.66846232
78regulation of leukocyte degranulation (GO:0043300)2.66809903
79positive regulation of fibroblast migration (GO:0010763)2.66619620
80regulation of neuronal synaptic plasticity (GO:0048168)2.64288197
81negative regulation of interleukin-12 production (GO:0032695)2.63427869
82pinocytosis (GO:0006907)2.62481757
83regulation of gamma-delta T cell differentiation (GO:0045586)2.62365137
84chondrocyte proliferation (GO:0035988)2.60862857
85negative regulation of smooth muscle cell migration (GO:0014912)2.60785418
86gamma-aminobutyric acid transport (GO:0015812)2.60498993
87positive regulation of macrophage cytokine production (GO:0060907)2.60354419
88gamma-aminobutyric acid signaling pathway (GO:0007214)2.59960528
89positive thymic T cell selection (GO:0045059)2.59789661
90G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.58871227
91presynaptic membrane organization (GO:0097090)2.58385872
92cellular extravasation (GO:0045123)2.57821519
93cerebral cortex radially oriented cell migration (GO:0021799)2.57668072
94positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.56100900
95regulation of synaptic vesicle transport (GO:1902803)2.55399736
96regulation of synaptic plasticity (GO:0048167)2.55345218
97synaptic vesicle endocytosis (GO:0048488)2.55174302
98neuron recognition (GO:0008038)2.55093194
99negative regulation of bone remodeling (GO:0046851)2.54936773
100hemidesmosome assembly (GO:0031581)2.54153267
101regulation of inositol phosphate biosynthetic process (GO:0010919)2.52644165
102proline transport (GO:0015824)2.52236641
103response to laminar fluid shear stress (GO:0034616)2.52087930
104regulation of synapse structural plasticity (GO:0051823)2.51786809
105positive regulation of membrane potential (GO:0045838)2.50296960
106startle response (GO:0001964)2.50149303
107positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.49879295
108sequestering of extracellular ligand from receptor (GO:0035581)2.49668685
109substrate-dependent cell migration (GO:0006929)2.49421454
110regulation of neurotransmitter secretion (GO:0046928)2.48830597
111G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.48707677
112skin morphogenesis (GO:0043589)2.48589395
113regulation of mast cell degranulation (GO:0043304)2.47222143
114regulation of T cell tolerance induction (GO:0002664)2.46656426
115regulation of platelet aggregation (GO:0090330)2.46158262
116transmission of nerve impulse (GO:0019226)2.46136032
117dendrite morphogenesis (GO:0048813)2.45747462
118response to histamine (GO:0034776)2.44847189
119sodium ion export (GO:0071436)2.44653778
120response to fluid shear stress (GO:0034405)2.44269793
121regulation of dendritic spine morphogenesis (GO:0061001)2.43935736
122membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.43596066
123axonal fasciculation (GO:0007413)2.43386852
124response to auditory stimulus (GO:0010996)2.41783132
125regulation of tolerance induction (GO:0002643)2.40736552
126negative regulation of granulocyte differentiation (GO:0030853)2.39883197
127neuronal action potential propagation (GO:0019227)2.39771829
128histone H3-K36 demethylation (GO:0070544)2.39741769
129regulation of mast cell activation involved in immune response (GO:0033006)2.38105951
130T cell selection (GO:0045058)2.37612321
131regulation of dendritic spine development (GO:0060998)2.35731592
132positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.35347288
133negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.34898491
134positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.34780347
135positive regulation by symbiont of host defense response (GO:0052509)2.34743704
136modulation by symbiont of host defense response (GO:0052031)2.34743704
137modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.34743704
138modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.34743704
139positive regulation by organism of defense response of other organism involved in symbiotic interact2.34743704
140modulation by symbiont of host immune response (GO:0052553)2.34743704
141chondrocyte differentiation (GO:0002062)2.33629922
142antigen processing and presentation of endogenous antigen (GO:0019883)2.32958954
143photoreceptor cell differentiation (GO:0046530)2.32665276
144eye photoreceptor cell differentiation (GO:0001754)2.32665276
145negative regulation of osteoblast proliferation (GO:0033689)2.32049879
146auditory behavior (GO:0031223)2.31786430
147macrophage activation involved in immune response (GO:0002281)2.31232906
148detection of other organism (GO:0098543)2.30764035
149adhesion of symbiont to host cell (GO:0044650)2.29736545
150virion attachment to host cell (GO:0019062)2.29736545
151negative regulation of fatty acid transport (GO:2000192)2.29101998
152thymic T cell selection (GO:0045061)2.28847182
153regulation of myeloid leukocyte mediated immunity (GO:0002886)2.27620167
154leukocyte aggregation (GO:0070486)2.27338308
155collagen metabolic process (GO:0032963)2.26444196
156regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.26421635
157positive regulation of synaptic transmission (GO:0050806)2.26409281
158clathrin coat assembly (GO:0048268)2.25781359
159cortical actin cytoskeleton organization (GO:0030866)2.25617498
160positive T cell selection (GO:0043368)2.25133872
161neurotransmitter secretion (GO:0007269)2.25064330
162cerebellar Purkinje cell differentiation (GO:0021702)2.23914988
163detection of molecule of bacterial origin (GO:0032490)2.22956160
164oligodendrocyte differentiation (GO:0048709)2.22931181
165cellular response to epinephrine stimulus (GO:0071872)2.22327829
166regulation of fibroblast migration (GO:0010762)2.22077906
167regulation of neurotransmitter transport (GO:0051588)2.22039760
168positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.21715668
169learning (GO:0007612)2.21606403
170antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.21452391
171regulation of monocyte chemotaxis (GO:0090025)2.20264457
172collagen catabolic process (GO:0030574)2.19417919
173regulation of NFAT protein import into nucleus (GO:0051532)2.19192244
174positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.19093180
175bone trabecula formation (GO:0060346)2.19077088
176membrane depolarization (GO:0051899)2.18313995
177regulation of dendritic cell antigen processing and presentation (GO:0002604)2.18150316
178germinal center formation (GO:0002467)2.17944382
179* chondroitin sulfate metabolic process (GO:0030204)2.17039876
180regulation of vesicle fusion (GO:0031338)2.16494305
181venous blood vessel morphogenesis (GO:0048845)2.16487638
182cell adhesion mediated by integrin (GO:0033627)2.16197329
183regulation of respiratory system process (GO:0044065)2.16147667
184cAMP-mediated signaling (GO:0019933)2.15505597
185regulation of T-helper 2 cell differentiation (GO:0045628)2.13823264
186antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.13313798
187positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.12797214
188insulin-like growth factor receptor signaling pathway (GO:0048009)2.11759637
189negative regulation of anoikis (GO:2000811)2.10931934

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.47213876
2* GBX2_23144817_ChIP-Seq_PC3_Human3.24700303
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.05067356
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.98189061
5* AR_21572438_ChIP-Seq_LNCaP_Human2.90483842
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.82275746
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.78616142
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.65861631
9MYB_21317192_ChIP-Seq_ERMYB_Mouse2.62003984
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.59669849
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.47509998
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41125694
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.40422970
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.40422970
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38044799
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30845985
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.29293176
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27128566
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.26328668
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.25816619
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.21070860
22* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.18930545
23* RUNX_20019798_ChIP-Seq_JUKART_Human2.18429483
24* VDR_24763502_ChIP-Seq_THP-1_Human2.17512868
25KDM2B_26808549_Chip-Seq_SUP-B15_Human2.15721442
26MTF2_20144788_ChIP-Seq_MESCs_Mouse2.09333884
27IRF8_27001747_Chip-Seq_BMDM_Mouse2.07680568
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05156738
29DROSHA_22980978_ChIP-Seq_HELA_Human2.04069432
30RNF2_27304074_Chip-Seq_ESCs_Mouse2.03377137
31VDR_21846776_ChIP-Seq_THP-1_Human2.01154597
32* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.96841803
33* MYC_22102868_ChIP-Seq_BL_Human1.96088617
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.95100037
35TP63_17297297_ChIP-ChIP_HaCaT_Human1.92692596
36SCL_19346495_ChIP-Seq_HPC-7_Human1.89937276
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.84989810
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.84907214
39TCF7_22412390_ChIP-Seq_EML_Mouse1.80884185
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.78504560
41FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.78245257
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.77896319
43TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.75885421
44* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.73128867
45WT1_19549856_ChIP-ChIP_CCG9911_Human1.72455261
46* BRD4_25478319_ChIP-Seq_HGPS_Human1.72410467
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71421325
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70453709
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.69867150
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69828582
51* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66046601
52KDM2B_26808549_Chip-Seq_DND41_Human1.65316529
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64345618
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62880377
55RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.62492155
56* REST_21632747_ChIP-Seq_MESCs_Mouse1.60692711
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.59823182
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.58671231
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.57492006
60* SMAD4_21799915_ChIP-Seq_A2780_Human1.54853322
61CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.54367747
62TRIM28_21343339_ChIP-Seq_HEK293_Human1.54330939
63SPI1_23127762_ChIP-Seq_K562_Human1.52988745
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.52959108
65* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51977198
66EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.51576099
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50718375
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.50232327
69* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49704688
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.48972877
71* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48928864
72TP53_16413492_ChIP-PET_HCT116_Human1.48673806
73ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48234013
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.48053162
75KDM2B_26808549_Chip-Seq_JURKAT_Human1.47338471
76RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46109309
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.45028264
78STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.44989504
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43714506
80* P300_19829295_ChIP-Seq_ESCs_Human1.43465675
81NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.43160956
82* MYB_26560356_Chip-Seq_TH2_Human1.42171571
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41096583
84RARB_27405468_Chip-Seq_BRAIN_Mouse1.40409385
85RUNX1_22412390_ChIP-Seq_EML_Mouse1.40169295
86E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.40115272
87PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.39406317
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39172147
89RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35179037
90ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35159234
91* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34051350
92CBX2_27304074_Chip-Seq_ESCs_Mouse1.31583167
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30130899
94* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27982658
95PIAS1_25552417_ChIP-Seq_VCAP_Human1.27523434
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24787168
97MAF_26560356_Chip-Seq_TH1_Human1.24769328
98KDM2B_26808549_Chip-Seq_K562_Human1.24685358
99OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23725691
100TAF15_26573619_Chip-Seq_HEK293_Human1.23693200
101RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23567474
102STAT3_23295773_ChIP-Seq_U87_Human1.23462926
103CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.21514733
104* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.21509884
105POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21219802
106* UTX_26944678_Chip-Seq_JUKART_Human1.20822806
107* AR_25329375_ChIP-Seq_VCAP_Human1.19411560
108* SOX2_21211035_ChIP-Seq_LN229_Gbm1.19181883
109MYB_26560356_Chip-Seq_TH1_Human1.18900321
110* TP53_18474530_ChIP-ChIP_U2OS_Human1.17700789
111DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17154561
112EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16294615
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16287441
114CJUN_26792858_Chip-Seq_BT549_Human1.16154434
115* ARNT_22903824_ChIP-Seq_MCF-7_Human1.15593545
116RING1B_27294783_Chip-Seq_ESCs_Mouse1.15552715
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15381443
118GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15065661
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14781039
120* VDR_24787735_ChIP-Seq_THP-1_Human1.14386626
121* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13289902
122* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13289902
123TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12840216
124AHR_22903824_ChIP-Seq_MCF-7_Human1.12817929
125* RXR_22108803_ChIP-Seq_LS180_Human1.12229832
126* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11899094
127* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11825005
128TCF4_23295773_ChIP-Seq_U87_Human1.11473458
129PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10922588
130PU_27001747_Chip-Seq_BMDM_Mouse1.10758887
131SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09900788
132* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08794771
133* PRDM14_20953172_ChIP-Seq_ESCs_Human1.08713957
134ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08670368
135NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08522102
136AR_19668381_ChIP-Seq_PC3_Human1.07647118
137CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07218158
138ER_23166858_ChIP-Seq_MCF-7_Human1.06838383
139REST_18959480_ChIP-ChIP_MESCs_Mouse1.06591280
140TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05587510
141* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05074570
142TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04723863
143NANOG_18555785_Chip-Seq_ESCs_Mouse1.04683632
144TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04643192
145SPI1_23547873_ChIP-Seq_NB4_Human1.03495930
146RING1B_27294783_Chip-Seq_NPCs_Mouse1.03419493
147RUNX2_22187159_ChIP-Seq_PCA_Human1.02782987
148P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02772428
149GATA1_19941826_ChIP-Seq_K562_Human1.01516543
150P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00370544
151* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00157574
152* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99996001
153EP300_21415370_ChIP-Seq_HL-1_Mouse0.99986098
154SMAD3_21741376_ChIP-Seq_HESCs_Human0.99792485
155SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99373344
156SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99373344
157* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98818225
158* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98153836
159CLOCK_20551151_ChIP-Seq_293T_Human0.98043575
160MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97840523
161* GATA1_19941827_ChIP-Seq_MEL_Mouse0.97364823
162E2F1_18555785_Chip-Seq_ESCs_Mouse0.97229771
163ZNF274_21170338_ChIP-Seq_K562_Hela0.96446844
164FUS_26573619_Chip-Seq_HEK293_Human0.96414612
165STAT4_19710469_ChIP-ChIP_TH1__Mouse0.95698655
166NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94703182
167PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94626969
168LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93634444
169Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.92903330
170IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.92484335
171TBX20_22080862_ChIP-Seq_HEART_Mouse0.92447363
172TBX20_22328084_ChIP-Seq_HEART_Mouse0.92447363
173NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91727107
174NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91727107
175BP1_19119308_ChIP-ChIP_Hs578T_Human0.91585771
176CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91415859
177EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91030898
178MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90780910
179* SMAD3_21741376_ChIP-Seq_ESCs_Human0.90725273
180LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90714807
181SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90630407
182JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88137463
183JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87053546
184IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.86563921

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.60342701
2MP0004859_abnormal_synaptic_plasticity4.62926728
3MP0003705_abnormal_hypodermis_morpholog4.29070189
4MP0003279_aneurysm3.42556454
5MP0003880_abnormal_central_pattern3.38813936
6MP0005275_abnormal_skin_tensile3.19422082
7MP0000569_abnormal_digit_pigmentation3.15765107
8MP0003635_abnormal_synaptic_transmissio2.92020626
9MP0004134_abnormal_chest_morphology2.77987739
10MP0009745_abnormal_behavioral_response2.47721321
11MP0009780_abnormal_chondrocyte_physiolo2.45716068
12MP0002063_abnormal_learning/memory/cond2.42365992
13MP0002064_seizures2.37030846
14MP0003300_gastrointestinal_ulcer2.36257375
15MP0005423_abnormal_somatic_nervous2.35038987
16MP0001486_abnormal_startle_reflex2.31213156
17MP0001968_abnormal_touch/_nociception2.16561779
18MP0009046_muscle_twitch2.14629109
19MP0002572_abnormal_emotion/affect_behav2.12817364
20MP0005257_abnormal_intraocular_pressure2.04566917
21MP0001835_abnormal_antigen_presentation2.04399100
22MP0003787_abnormal_imprinting1.97349942
23MP0004270_analgesia1.95751619
24MP0002933_joint_inflammation1.92554876
25MP0002736_abnormal_nociception_after1.89775326
26MP0003566_abnormal_cell_adhesion1.89417170
27MP0004858_abnormal_nervous_system1.85328839
28MP0006054_spinal_hemorrhage1.84044004
29MP0000767_abnormal_smooth_muscle1.82167663
30MP0003828_pulmonary_edema1.80844395
31MP0005000_abnormal_immune_tolerance1.74408515
32MP0003763_abnormal_thymus_physiology1.72381284
33MP0003950_abnormal_plasma_membrane1.72143322
34MP0002735_abnormal_chemical_nociception1.70544111
35MP0003172_abnormal_lysosome_physiology1.69144744
36MP0003303_peritoneal_inflammation1.67482814
37MP0009384_cardiac_valve_regurgitation1.66013538
38MP0002067_abnormal_sensory_capabilities1.61503711
39MP0000778_abnormal_nervous_system1.60074397
40MP0005023_abnormal_wound_healing1.59473669
41MP0005645_abnormal_hypothalamus_physiol1.59060073
42MP0009250_abnormal_appendicular_skeleto1.58622106
43MP0002282_abnormal_trachea_morphology1.58516799
44MP0003183_abnormal_peptide_metabolism1.57761633
45MP0004742_abnormal_vestibular_system1.57185541
46MP0002272_abnormal_nervous_system1.56933843
47MP0003724_increased_susceptibility_to1.55981992
48MP0004272_abnormal_basement_membrane1.55700806
49MP0004947_skin_inflammation1.53467562
50MP0005623_abnormal_meninges_morphology1.51603799
51MP0001501_abnormal_sleep_pattern1.51531807
52MP0002060_abnormal_skin_morphology1.51121622
53MP0002734_abnormal_mechanical_nocicepti1.50526128
54MP0002089_abnormal_postnatal_growth/wei1.50108244
55MP0002396_abnormal_hematopoietic_system1.48668971
56MP0001800_abnormal_humoral_immune1.48517806
57MP0001440_abnormal_grooming_behavior1.47976177
58MP0003448_altered_tumor_morphology1.47572052
59MP0000685_abnormal_immune_system1.46825115
60MP0005551_abnormal_eye_electrophysiolog1.46731853
61MP0006082_CNS_inflammation1.45926214
62MP0004808_abnormal_hematopoietic_stem1.45057152
63MP0004885_abnormal_endolymph1.42645060
64MP0010352_gastrointestinal_tract_polyps1.41681804
65MP0002420_abnormal_adaptive_immunity1.39687647
66MP0002405_respiratory_system_inflammati1.39614336
67MP0002452_abnormal_antigen_presenting1.38879141
68MP0001299_abnormal_eye_distance/1.38841515
69MP0005646_abnormal_pituitary_gland1.38578857
70MP0001819_abnormal_immune_cell1.36826560
71MP0002557_abnormal_social/conspecific_i1.33783877
72MP0002723_abnormal_immune_serum1.32772325
73MP0010368_abnormal_lymphatic_system1.32079085
74MP0002148_abnormal_hypersensitivity_rea1.32026015
75MP0000163_abnormal_cartilage_morphology1.31219920
76MP0008569_lethality_at_weaning1.30910358
77MP0001542_abnormal_bone_strength1.30353292
78MP0003690_abnormal_glial_cell1.30317403
79MP0005025_abnormal_response_to1.26783121
80MP0005076_abnormal_cell_differentiation1.26733686
81MP0005058_abnormal_lysosome_morphology1.25419084
82MP0001963_abnormal_hearing_physiology1.24908900
83MP0001849_ear_inflammation1.24636152
84MP0005464_abnormal_platelet_physiology1.23163624
85MP0002398_abnormal_bone_marrow1.20817095
86MP0002184_abnormal_innervation1.19393067
87MP0000920_abnormal_myelination1.17014903
88MP0005508_abnormal_skeleton_morphology1.16402742
89MP0002909_abnormal_adrenal_gland1.16358675
90MP0001970_abnormal_pain_threshold1.16333448
91MP0002133_abnormal_respiratory_system1.16123467
92MP0005388_respiratory_system_phenotype1.16123467
93MP0004510_myositis1.15977138
94MP0005397_hematopoietic_system_phenotyp1.15712473
95MP0001545_abnormal_hematopoietic_system1.15712473
96MP0003191_abnormal_cellular_cholesterol1.15070875
97MP0001502_abnormal_circadian_rhythm1.12707500
98MP0003634_abnormal_glial_cell1.10674507
99MP0000716_abnormal_immune_system1.09557779
100MP0002115_abnormal_skeleton_extremities1.07928270
101MP0005503_abnormal_tendon_morphology1.06920208
102MP0001851_eye_inflammation1.06887929
103MP0005164_abnormal_response_to1.06865098
104MP0005174_abnormal_tail_pigmentation1.05789990
105MP0005595_abnormal_vascular_smooth1.05294417
106MP0002733_abnormal_thermal_nociception1.05148931
107MP0005671_abnormal_response_to1.05142566
108MP0001986_abnormal_taste_sensitivity1.04902522
109MP0001188_hyperpigmentation1.04703583
110MP0003879_abnormal_hair_cell1.04376343
111MP0003075_altered_response_to1.03916787
112MP0002882_abnormal_neuron_morphology1.02663440
113MP0005167_abnormal_blood-brain_barrier1.01511853
114MP0001533_abnormal_skeleton_physiology0.99826589
115MP0001853_heart_inflammation0.99759043
116MP0009278_abnormal_bone_marrow0.98871633
117MP0002090_abnormal_vision0.98860680
118MP0005409_darkened_coat_color0.98660123
119MP0000858_altered_metastatic_potential0.98037151
120MP0002113_abnormal_skeleton_development0.96987350
121MP0003122_maternal_imprinting0.96824174
122MP0004883_abnormal_blood_vessel0.95816683
123MP0000733_abnormal_muscle_development0.95465425
124MP0002009_preneoplasia0.94572617
125MP0010155_abnormal_intestine_physiology0.94063761
126MP0000955_abnormal_spinal_cord0.93779569
127MP0004142_abnormal_muscle_tone0.93591876
128MP0003633_abnormal_nervous_system0.92589388
129MP0004811_abnormal_neuron_physiology0.91612295
130MP0002998_abnormal_bone_remodeling0.90212440
131MP0002066_abnormal_motor_capabilities/c0.89608840
132MP0005386_behavior/neurological_phenoty0.88716023
133MP0004924_abnormal_behavior0.88716023
134MP0009785_altered_susceptibility_to0.88125540
135MP0003091_abnormal_cell_migration0.87817650
136MP0000015_abnormal_ear_pigmentation0.87770969
137MP0000428_abnormal_craniofacial_morphol0.86814429
138MP0002722_abnormal_immune_system0.86720852
139MP0001958_emphysema0.86577111
140MP0003045_fibrosis0.86398674
141MP0005390_skeleton_phenotype0.85525337
142MP0000026_abnormal_inner_ear0.83820368
143MP0000604_amyloidosis0.83646079
144MP0005621_abnormal_cell_physiology0.82589647
145MP0002429_abnormal_blood_cell0.82089753
146MP0009840_abnormal_foam_cell0.81725781
147MP0000631_abnormal_neuroendocrine_gland0.81538722
148MP0002116_abnormal_craniofacial_bone0.81531493
149MP0004484_altered_response_of0.80762166
150MP0001177_atelectasis0.80578132
151MP0005253_abnormal_eye_physiology0.78892095
152MP0000703_abnormal_thymus_morphology0.78685210
153MP0003436_decreased_susceptibility_to0.77873511
154MP0002152_abnormal_brain_morphology0.76713029
155MP0001943_abnormal_respiration0.75822199
156MP0001243_abnormal_dermal_layer0.75172868
157MP0002254_reproductive_system_inflammat0.74477390
158MP0000689_abnormal_spleen_morphology0.73882845
159MP0002419_abnormal_innate_immunity0.73638694
160MP0003453_abnormal_keratinocyte_physiol0.73588695
161MP0002877_abnormal_melanocyte_morpholog0.73425335
162MP0003646_muscle_fatigue0.72921403
163MP0002109_abnormal_limb_morphology0.72812285
164MP0002896_abnormal_bone_mineralization0.71652413
165MP0003631_nervous_system_phenotype0.71249165
166MP0002295_abnormal_pulmonary_circulatio0.71018457
167MP0000249_abnormal_blood_vessel0.70789783
168MP0008004_abnormal_stomach_pH0.69545796
169MP0002229_neurodegeneration0.68741895
170MP0010386_abnormal_urinary_bladder0.67500058
171MP0001790_abnormal_immune_system0.67264344
172MP0005387_immune_system_phenotype0.67264344
173MP0005171_absent_coat_pigmentation0.66889936
174MP0003795_abnormal_bone_structure0.65953054

Predicted human phenotypes

RankGene SetZ-score
1* Epiphyseal dysplasia (HP:0002656)7.12756425
2Irregular epiphyses (HP:0010582)5.66134724
3Small epiphyses (HP:0010585)5.41993905
4Vitreoretinal degeneration (HP:0000655)5.33208075
5Protrusio acetabuli (HP:0003179)4.76213923
6Hypoplastic ischia (HP:0003175)4.74296567
7Premature rupture of membranes (HP:0001788)4.67300731
8Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.40288434
9Flat capital femoral epiphysis (HP:0003370)4.16434846
10Aortic aneurysm (HP:0004942)4.12489439
11Abnormality of the ischium (HP:0003174)4.07380231
12Aortic dissection (HP:0002647)3.75784807
13Spondylolisthesis (HP:0003302)3.65958212
14Ankle contracture (HP:0006466)3.50983158
15Cupped ribs (HP:0000887)3.49347297
16Genu varum (HP:0002970)3.47364165
17Syringomyelia (HP:0003396)3.43672402
18Spinal cord lesions (HP:0100561)3.43672402
19Flattened epiphyses (HP:0003071)3.41139949
20Mild short stature (HP:0003502)3.38470781
21Delayed epiphyseal ossification (HP:0002663)3.37010894
22Focal motor seizures (HP:0011153)3.28448393
23Follicular hyperkeratosis (HP:0007502)3.25349516
24Abnormality of the vertebral endplates (HP:0005106)3.19504074
25Short femoral neck (HP:0100864)3.18468042
26Neonatal short-limb short stature (HP:0008921)3.17816133
27Abnormal tarsal ossification (HP:0008369)3.12708352
28Atrophic scars (HP:0001075)3.09593112
29Dilatation of the ascending aorta (HP:0005111)3.08407821
30Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.05952878
31Abnormality of femoral epiphyses (HP:0006499)3.05952878
32Absent frontal sinuses (HP:0002688)3.02783776
33Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.01400207
34Flat acetabular roof (HP:0003180)3.00261479
35Vascular tortuosity (HP:0004948)2.94340752
36Broad metatarsal (HP:0001783)2.93863948
37Arthropathy (HP:0003040)2.85125600
38Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.84511386
39Absent epiphyses (HP:0010577)2.84511386
40Abnormality of the epiphysis of the femoral head (HP:0010574)2.81160916
41Peritonitis (HP:0002586)2.79491378
42* Genu recurvatum (HP:0002816)2.74217732
43Shallow orbits (HP:0000586)2.73606067
44Slender build (HP:0001533)2.70611824
45Abnormality of the femoral head (HP:0003368)2.68581765
46Osteoarthritis (HP:0002758)2.68343163
47Arterial tortuosity (HP:0005116)2.68101589
48Irregular vertebral endplates (HP:0003301)2.67298170
49Wormian bones (HP:0002645)2.63323594
50Spinal rigidity (HP:0003306)2.58811815
51Soft skin (HP:0000977)2.56350576
52Mitral valve prolapse (HP:0001634)2.55927699
53Abnormality of the pubic bones (HP:0003172)2.55096601
54Aortic regurgitation (HP:0001659)2.53959248
55Metaphyseal cupping (HP:0003021)2.52769057
56Metaphyseal dysplasia (HP:0100255)2.51462820
57Barrel-shaped chest (HP:0001552)2.49365536
58Aplasia/hypoplasia of the femur (HP:0005613)2.46617550
59Increased variability in muscle fiber diameter (HP:0003557)2.46188747
60Epileptic encephalopathy (HP:0200134)2.44735633
61Fragile skin (HP:0001030)2.44304213
62Mixed hearing impairment (HP:0000410)2.43518272
63Bladder diverticulum (HP:0000015)2.43492864
64Abnormality of incisor morphology (HP:0011063)2.41491443
65Limited elbow extension (HP:0001377)2.40136796
66Osteolytic defects of the hand bones (HP:0009699)2.39407797
67Osteolytic defects of the phalanges of the hand (HP:0009771)2.39407797
68Cerebral aneurysm (HP:0004944)2.38837852
69Broad ribs (HP:0000885)2.38356120
70Metaphyseal irregularity (HP:0003025)2.38054159
71Enlarged epiphyses (HP:0010580)2.36639733
72Abnormal foot bone ossification (HP:0010675)2.32120276
73Mitral regurgitation (HP:0001653)2.31595403
74Type 1 muscle fiber predominance (HP:0003803)2.31004103
75Focal seizures (HP:0007359)2.30504376
76Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.30181809
77Dysostosis multiplex (HP:0000943)2.30030445
78Abnormal vertebral ossification (HP:0100569)2.26940120
79Waddling gait (HP:0002515)2.26693128
80Thin bony cortex (HP:0002753)2.23539734
81Limited hip movement (HP:0008800)2.22187487
82Abnormality of the proximal phalanges of the hand (HP:0009834)2.21932644
83* Joint laxity (HP:0001388)2.19395220
84Aneurysm (HP:0002617)2.17718490
85Abnormal delayed hypersensitivity skin test (HP:0002963)2.17265649
86Hypoplasia of the odontoid process (HP:0003311)2.17240146
87Abnormality of skeletal muscle fiber size (HP:0012084)2.15796722
88Febrile seizures (HP:0002373)2.14672705
89Fibular hypoplasia (HP:0003038)2.14424125
90Progressive cerebellar ataxia (HP:0002073)2.14022727
91Broad-based gait (HP:0002136)2.12198359
92Spontaneous hematomas (HP:0007420)2.11750877
93* Blue sclerae (HP:0000592)2.11043498
94Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.10362864
95Exostoses (HP:0100777)2.08185296
96Abnormality of the phalanges of the 2nd finger (HP:0009541)2.07606959
97Biconcave vertebral bodies (HP:0004586)2.06940202
98Disproportionate tall stature (HP:0001519)2.06577393
99Joint stiffness (HP:0001387)2.02836751
100Persistence of primary teeth (HP:0006335)2.02789899
101Chronic mucocutaneous candidiasis (HP:0002728)2.02593026
102Recurrent cutaneous fungal infections (HP:0011370)2.02593026
103Protuberant abdomen (HP:0001538)2.02206627
104Vertebral compression fractures (HP:0002953)1.99660758
105Bowel diverticulosis (HP:0005222)1.98152215
106Overgrowth (HP:0001548)1.97081978
107Visual hallucinations (HP:0002367)1.95961008
108Hypoventilation (HP:0002791)1.95362724
109Cellulitis (HP:0100658)1.93785478
110Abnormality of binocular vision (HP:0011514)1.92381605
111Diplopia (HP:0000651)1.92381605
112Hyperextensible skin (HP:0000974)1.91734613
113T lymphocytopenia (HP:0005403)1.91687392
114Abnormality of the frontal sinuses (HP:0002687)1.91518724
115Hypoplastic pelvis (HP:0008839)1.89577606
116Narrow palate (HP:0000189)1.88832753
117Ovoid vertebral bodies (HP:0003300)1.88814366
118Aortic valve stenosis (HP:0001650)1.88422139
119Increased cerebral lipofuscin (HP:0011813)1.88149381
120Long eyelashes (HP:0000527)1.87712360
121Recurrent viral infections (HP:0004429)1.87114182
122Hypoplasia of the iris (HP:0007676)1.86861251
123Coxa vara (HP:0002812)1.86565110
124Lumbar hyperlordosis (HP:0002938)1.85821739
125Flared iliac wings (HP:0002869)1.85537847
126Mucopolysacchariduria (HP:0008155)1.84811418
127Urinary glycosaminoglycan excretion (HP:0003541)1.84811418
128Spinal cord compression (HP:0002176)1.84680172
129Abnormality of the odontoid process (HP:0003310)1.84217668
130Eczematoid dermatitis (HP:0000976)1.84087093
131Delayed closure of the anterior fontanelle (HP:0001476)1.83941438
132Natal tooth (HP:0000695)1.82633493
133Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.81756616
134Thoracolumbar scoliosis (HP:0002944)1.81523899
135Camptodactyly of toe (HP:0001836)1.81193153
136Disproportionate short-trunk short stature (HP:0003521)1.80459616
137Mesomelia (HP:0003027)1.79536595
138Wide anterior fontanel (HP:0000260)1.78501098
139Obstructive sleep apnea (HP:0002870)1.78216374
140Genu valgum (HP:0002857)1.77821670
141Myositis (HP:0100614)1.77513942
142Hypoplastic ilia (HP:0000946)1.76522737
143Agammaglobulinemia (HP:0004432)1.76253860
144Abnormality of mucopolysaccharide metabolism (HP:0011020)1.75951836
145Abnormality of polysaccharide metabolism (HP:0011012)1.75951836
146Abnormality of glycosaminoglycan metabolism (HP:0004371)1.75951836
147Recurrent abscess formation (HP:0002722)1.75090536
148Abnormality of macrophages (HP:0004311)1.75085746
149Abnormality of dentin (HP:0010299)1.74549845
150Abnormality of T cell number (HP:0011839)1.74107082
151Supranuclear gaze palsy (HP:0000605)1.73877940
152Abnormality of oral frenula (HP:0000190)1.73651948
153Recurrent bacterial skin infections (HP:0005406)1.73276044
154Abnormality of the middle phalanges of the toes (HP:0010183)1.72207931
155Abnormality of the lumbar spine (HP:0100712)1.71188867
156Abnormality of skull ossification (HP:0002703)1.70433913
157Abnormality of the intervertebral disk (HP:0005108)1.70428874
158Dislocated radial head (HP:0003083)1.70391623
159Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.68162171
160Recurrent fungal infections (HP:0002841)1.67773353
161Increased neuronal autofluorescent lipopigment (HP:0002074)1.67397100
162Platyspondyly (HP:0000926)1.66199156
163Hypoplastic iliac wings (HP:0002866)1.66009093
164Emphysema (HP:0002097)1.65201741
165Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.65088187
166Congenital stationary night blindness (HP:0007642)1.64732326
167Short middle phalanx of finger (HP:0005819)1.64149944
168Elbow flexion contracture (HP:0002987)1.64085319
169Myokymia (HP:0002411)1.62136223
170Vertebral clefting (HP:0008428)1.61541881
171Cervical subluxation (HP:0003308)1.61260679
172Delayed cranial suture closure (HP:0000270)1.60881768
173Drooling (HP:0002307)1.59779622
174Excessive salivation (HP:0003781)1.59779622
175Micromelia (HP:0002983)1.58961982
176Gaze-evoked nystagmus (HP:0000640)1.58836547
177Abnormality of the middle phalanges of the hand (HP:0009833)1.58187065
178Absence seizures (HP:0002121)1.57951609
179Long clavicles (HP:0000890)1.57901531
180Ulnar bowing (HP:0003031)1.57882535
181Joint contractures involving the joints of the feet (HP:0100492)1.57828975
182Absent speech (HP:0001344)1.55634089
183Hip contracture (HP:0003273)1.55545363
184Flared metaphyses (HP:0003015)1.55400219
185Aplasia of the phalanges of the hand (HP:0009802)1.54639553
186Aplasia involving bones of the extremities (HP:0009825)1.54639553
187Aplasia involving bones of the upper limbs (HP:0009823)1.54639553
188Fetal akinesia sequence (HP:0001989)1.54344650

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.59781410
2NTRK33.35605339
3EPHA43.17534383
4RIPK43.11154494
5DDR22.51736660
6SIK22.38927239
7TNIK2.37000468
8PDGFRA2.28141358
9MAP4K12.25414168
10CDK122.17003166
11FES2.15117562
12TRIB32.06540479
13TAOK32.06382878
14NTRK22.04812987
15ERN12.01589709
16TTN2.01023908
17PRPF4B1.83596957
18MAP3K101.82741640
19MAP3K91.78618142
20CAMK1G1.76411899
21TGFBR21.74338987
22MAP3K131.72236838
23PLK21.72066405
24MAP3K41.71433171
25PAK61.66752874
26MARK11.65342403
27MAP2K31.65120708
28NEK91.64069218
29KIT1.58552863
30ZAP701.53508602
31PRKD31.52595155
32CDC42BPA1.47605326
33TRPM71.45383565
34JAK31.43114106
35DAPK21.43113090
36MAP2K71.39468553
37STK241.38828429
38TYK21.38053002
39KSR11.37330935
40EEF2K1.34598711
41ERBB31.34556414
42NEK61.33539888
43JAK11.33183451
44BMPR21.32798344
45TXK1.30467934
46MOS1.28847460
47BLK1.27788224
48DYRK1A1.26785362
49NME11.25269878
50MAPK131.24401116
51TAOK11.20696282
52FGR1.19793359
53STK101.18986646
54CAMKK11.18134199
55SIK31.17546805
56PAK21.17484078
57MAP3K61.17037425
58PIK3CG1.15607152
59CDK51.14669719
60CAMK1D1.12682489
61GRK11.11760390
62MKNK21.10747543
63MINK11.09401293
64DMPK1.08881352
65IKBKE1.05728052
66TBK11.04977199
67MYLK1.04897004
68BTK0.99261195
69MAPK70.98988213
70CDK60.98542876
71RPS6KA20.95764118
72SGK10.93071737
73LATS20.92756147
74LATS10.92483722
75NTRK10.92242619
76PRKCH0.91762556
77SIK10.90282243
78CSK0.87325620
79KSR20.85087863
80MAP3K120.83881349
81TYRO30.83856312
82TNK20.83813973
83TAOK20.81706587
84CLK10.81192485
85SGK20.80687988
86RPS6KC10.80476388
87RPS6KL10.80476388
88CDK190.78901257
89PRKCG0.77943504
90PKN20.77539124
91HCK0.77418430
92MAPK120.77235383
93CAMK10.76744735
94MELK0.76402701
95MTOR0.75789869
96SGK30.70623395
97TESK20.70606800
98LCK0.69802016
99AKT30.68801193
100CAMK2A0.68178760
101STK110.67070442
102BRD40.67013063
103MAP3K10.65359080
104PDGFRB0.64414118
105ICK0.64399426
106CDK30.63799986
107RPS6KA60.63752785
108FYN0.63635028
109TEC0.63432420
110IRAK30.62880955
111MKNK10.61785810
112JAK20.61160936
113IKBKB0.60972135
114MAP2K40.60652910
115MAP3K30.60503513
116SGK2230.60361063
117SGK4940.60361063
118PRKD20.60291948
119GRK50.59818202
120SYK0.59628701
121PRKCQ0.58719823
122PTK20.58400179
123FLT30.58125605
124PKN10.57980833
125MARK20.57814348
126MAPK40.57025188
127CDK40.56219987
128MARK30.56136522
129NUAK10.56094936
130IRAK40.55041166
131ALK0.54408396
132RAF10.54163565
133STK380.54120669
134GRK70.54055574
135FGFR30.53821767
136MAPK100.53654835
137PRKCE0.52973689
138DAPK10.52619704
139PTK2B0.52604405
140CSF1R0.52420107
141RIPK10.52049158
142IRAK10.51914659
143HIPK20.51641383
144MATK0.51408454
145WNK10.51212338
146DYRK1B0.50350828
147UHMK10.49227360
148MAP3K140.48493244
149PNCK0.46497330
150PRKG10.45242754
151IRAK20.44940665
152PHKG10.44122066
153PHKG20.44122066
154EPHB10.43830562
155CAMK40.42259369
156PDK10.40901935
157LYN0.40757248
158MAP3K70.39964620
159GRK60.39579024
160ROCK20.39482723
161MAPKAPK50.39445295
162CAMKK20.39035695
163RET0.39020894
164SRC0.38950420

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.46893045
2Olfactory transduction_Homo sapiens_hsa047402.10006079
3Glutamatergic synapse_Homo sapiens_hsa047241.97150868
4Other glycan degradation_Homo sapiens_hsa005111.95123809
5Phototransduction_Homo sapiens_hsa047441.91077008
6Morphine addiction_Homo sapiens_hsa050321.89218539
7Circadian entrainment_Homo sapiens_hsa047131.86126301
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.81121982
9* Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.78689012
10GABAergic synapse_Homo sapiens_hsa047271.67710872
11Salivary secretion_Homo sapiens_hsa049701.65292567
12Long-term potentiation_Homo sapiens_hsa047201.64163310
13Synaptic vesicle cycle_Homo sapiens_hsa047211.62042369
14Acute myeloid leukemia_Homo sapiens_hsa052211.53545789
15Long-term depression_Homo sapiens_hsa047301.51322444
16Gastric acid secretion_Homo sapiens_hsa049711.42976057
17Amphetamine addiction_Homo sapiens_hsa050311.41469429
18Cholinergic synapse_Homo sapiens_hsa047251.41443232
19Amoebiasis_Homo sapiens_hsa051461.37114682
20Toxoplasmosis_Homo sapiens_hsa051451.35631816
21Oxytocin signaling pathway_Homo sapiens_hsa049211.33683291
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32818630
23Serotonergic synapse_Homo sapiens_hsa047261.31365570
24Renin secretion_Homo sapiens_hsa049241.31144548
25Dopaminergic synapse_Homo sapiens_hsa047281.29880165
26Insulin secretion_Homo sapiens_hsa049111.29416538
27Glioma_Homo sapiens_hsa052141.28528960
28TNF signaling pathway_Homo sapiens_hsa046681.27396061
29Dorso-ventral axis formation_Homo sapiens_hsa043201.24927404
30Calcium signaling pathway_Homo sapiens_hsa040201.22608630
31Taste transduction_Homo sapiens_hsa047421.20817329
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.19758019
33Hepatitis B_Homo sapiens_hsa051611.19576185
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19571410
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.18909277
36ECM-receptor interaction_Homo sapiens_hsa045121.16722997
37B cell receptor signaling pathway_Homo sapiens_hsa046621.16547879
38cAMP signaling pathway_Homo sapiens_hsa040241.14423855
39GnRH signaling pathway_Homo sapiens_hsa049121.14387880
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13135270
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.12738201
42Phospholipase D signaling pathway_Homo sapiens_hsa040721.11057808
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10455228
44Axon guidance_Homo sapiens_hsa043601.10102223
45Small cell lung cancer_Homo sapiens_hsa052221.10087851
46ErbB signaling pathway_Homo sapiens_hsa040121.09841543
47Measles_Homo sapiens_hsa051621.07588384
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06768746
49Allograft rejection_Homo sapiens_hsa053301.05635028
50Jak-STAT signaling pathway_Homo sapiens_hsa046301.05096519
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04832877
52Cocaine addiction_Homo sapiens_hsa050301.04301180
53Hematopoietic cell lineage_Homo sapiens_hsa046401.04274629
54Gap junction_Homo sapiens_hsa045401.03447663
55Notch signaling pathway_Homo sapiens_hsa043301.02649385
56Prolactin signaling pathway_Homo sapiens_hsa049171.02483907
57Glycosaminoglycan degradation_Homo sapiens_hsa005311.02380015
58cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02301303
59Choline metabolism in cancer_Homo sapiens_hsa052311.02293386
60Prostate cancer_Homo sapiens_hsa052151.01827666
61Graft-versus-host disease_Homo sapiens_hsa053321.01724465
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.01499154
63Influenza A_Homo sapiens_hsa051641.00972583
64Viral myocarditis_Homo sapiens_hsa054161.00746093
65NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00083284
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99533794
67Type II diabetes mellitus_Homo sapiens_hsa049300.99039114
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98540656
69Osteoclast differentiation_Homo sapiens_hsa043800.98024615
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97811103
71Asthma_Homo sapiens_hsa053100.97688067
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97054914
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96384299
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96346463
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95683460
76Bladder cancer_Homo sapiens_hsa052190.95269788
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94736503
78Protein digestion and absorption_Homo sapiens_hsa049740.92218578
79Estrogen signaling pathway_Homo sapiens_hsa049150.91843336
80Chemokine signaling pathway_Homo sapiens_hsa040620.91570612
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.91257858
82Sphingolipid metabolism_Homo sapiens_hsa006000.90538225
83Autoimmune thyroid disease_Homo sapiens_hsa053200.90013146
84MAPK signaling pathway_Homo sapiens_hsa040100.88939029
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.88660683
86Shigellosis_Homo sapiens_hsa051310.88517964
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.87156117
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86982287
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86415549
90Primary immunodeficiency_Homo sapiens_hsa053400.85087977
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82804334
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82509180
93Staphylococcus aureus infection_Homo sapiens_hsa051500.81851462
94Lysosome_Homo sapiens_hsa041420.81549959
95Melanogenesis_Homo sapiens_hsa049160.80870174
96Focal adhesion_Homo sapiens_hsa045100.80728424
97Hepatitis C_Homo sapiens_hsa051600.79982733
98mTOR signaling pathway_Homo sapiens_hsa041500.79418766
99Pancreatic secretion_Homo sapiens_hsa049720.78879205
100HTLV-I infection_Homo sapiens_hsa051660.77502655
101Pertussis_Homo sapiens_hsa051330.76551266
102Ras signaling pathway_Homo sapiens_hsa040140.76453019
103Tuberculosis_Homo sapiens_hsa051520.76130403
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75093644
105Pathways in cancer_Homo sapiens_hsa052000.74800238
106Apoptosis_Homo sapiens_hsa042100.74558139
107* Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74491284
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72782882
109Rap1 signaling pathway_Homo sapiens_hsa040150.72559337
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71495466
111African trypanosomiasis_Homo sapiens_hsa051430.71442845
112FoxO signaling pathway_Homo sapiens_hsa040680.70798743
113Leishmaniasis_Homo sapiens_hsa051400.70251228
114Collecting duct acid secretion_Homo sapiens_hsa049660.70005692
115VEGF signaling pathway_Homo sapiens_hsa043700.68925575
116Dilated cardiomyopathy_Homo sapiens_hsa054140.68843159
117T cell receptor signaling pathway_Homo sapiens_hsa046600.68236964
118Renal cell carcinoma_Homo sapiens_hsa052110.67957938
119Platelet activation_Homo sapiens_hsa046110.67605643
120Malaria_Homo sapiens_hsa051440.67209643
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66797063
122Salmonella infection_Homo sapiens_hsa051320.66722615
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.66637461
124Adherens junction_Homo sapiens_hsa045200.66190706
125Herpes simplex infection_Homo sapiens_hsa051680.65627692
126Phagosome_Homo sapiens_hsa041450.64811650
127Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64537857
128Endocytosis_Homo sapiens_hsa041440.64494639
129Rheumatoid arthritis_Homo sapiens_hsa053230.64485943
130Antigen processing and presentation_Homo sapiens_hsa046120.62932732
131Non-small cell lung cancer_Homo sapiens_hsa052230.62836241
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62239782
133Ovarian steroidogenesis_Homo sapiens_hsa049130.61163323
134Colorectal cancer_Homo sapiens_hsa052100.60602420
135AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60381073
136Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59448047
137Proteoglycans in cancer_Homo sapiens_hsa052050.59049815
138Pancreatic cancer_Homo sapiens_hsa052120.57693894
139Wnt signaling pathway_Homo sapiens_hsa043100.57258802
140MicroRNAs in cancer_Homo sapiens_hsa052060.57095245
141Melanoma_Homo sapiens_hsa052180.56223557
142Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55383893
143Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55101766
144Inositol phosphate metabolism_Homo sapiens_hsa005620.55028367
145Endometrial cancer_Homo sapiens_hsa052130.54305626
146Chronic myeloid leukemia_Homo sapiens_hsa052200.54140953

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »