YAF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a zinc finger containing protein that functions in the regulation of transcription. This protein was identified as an interacting partner of transcriptional repressor protein Yy1, and also interacts with other transcriptional regulators, including Myc and Polycomb. This protein can promote proteolysis of Yy1. Multiple alternatively spliced transcript variants have been found. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.80896768
2synaptic vesicle maturation (GO:0016188)5.63968042
3glutamate secretion (GO:0014047)5.55311157
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.53533014
5regulation of synaptic vesicle exocytosis (GO:2000300)5.47718296
6behavioral response to nicotine (GO:0035095)5.32836463
7neuronal action potential propagation (GO:0019227)5.17295539
8regulation of synaptic vesicle transport (GO:1902803)4.91044831
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.90210089
10vocalization behavior (GO:0071625)4.90169448
11locomotory exploration behavior (GO:0035641)4.88969463
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.87011878
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.86167668
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.79407653
15protein localization to synapse (GO:0035418)4.71957134
16neuron cell-cell adhesion (GO:0007158)4.68502756
17regulation of glutamate receptor signaling pathway (GO:1900449)4.53394949
18neurotransmitter secretion (GO:0007269)4.17963224
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.13737948
20negative regulation of synaptic transmission, GABAergic (GO:0032229)4.08270728
21exploration behavior (GO:0035640)4.05981218
22presynaptic membrane assembly (GO:0097105)4.05336608
23regulation of neuronal synaptic plasticity (GO:0048168)4.03560337
24presynaptic membrane organization (GO:0097090)3.97763310
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.97198875
26ionotropic glutamate receptor signaling pathway (GO:0035235)3.96350453
27kynurenine metabolic process (GO:0070189)3.92937600
28tryptophan catabolic process (GO:0006569)3.91021208
29indole-containing compound catabolic process (GO:0042436)3.91021208
30indolalkylamine catabolic process (GO:0046218)3.91021208
31regulation of synapse structural plasticity (GO:0051823)3.89463336
32synaptic transmission, glutamatergic (GO:0035249)3.81823834
33neuron-neuron synaptic transmission (GO:0007270)3.81452933
34gamma-aminobutyric acid signaling pathway (GO:0007214)3.80210018
35neurotransmitter-gated ion channel clustering (GO:0072578)3.79220955
36neuron recognition (GO:0008038)3.72159420
37detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.72087344
38neural tube formation (GO:0001841)3.70609053
39glutamate receptor signaling pathway (GO:0007215)3.68293955
40long-term synaptic potentiation (GO:0060291)3.66323530
41positive regulation of membrane potential (GO:0045838)3.63948220
42postsynaptic membrane organization (GO:0001941)3.54599862
43indolalkylamine metabolic process (GO:0006586)3.54486347
44dendritic spine morphogenesis (GO:0060997)3.52918457
45layer formation in cerebral cortex (GO:0021819)3.50518045
46regulation of neurotransmitter secretion (GO:0046928)3.48210432
47long-term memory (GO:0007616)3.47603546
48L-fucose catabolic process (GO:0042355)3.47308446
49fucose catabolic process (GO:0019317)3.47308446
50L-fucose metabolic process (GO:0042354)3.47308446
51cellular ketone body metabolic process (GO:0046950)3.45346728
52regulation of excitatory postsynaptic membrane potential (GO:0060079)3.40609237
53regulation of vesicle fusion (GO:0031338)3.38127656
54axonal fasciculation (GO:0007413)3.38091450
55tryptophan metabolic process (GO:0006568)3.37154828
56neurotransmitter transport (GO:0006836)3.36619747
57regulation of synaptic plasticity (GO:0048167)3.35627332
58regulation of dendritic spine morphogenesis (GO:0061001)3.35345872
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.31061386
60establishment of protein localization to Golgi (GO:0072600)3.27976453
61response to pheromone (GO:0019236)3.27934067
62detection of light stimulus involved in sensory perception (GO:0050962)3.26122227
63detection of light stimulus involved in visual perception (GO:0050908)3.26122227
64DNA deamination (GO:0045006)3.26020373
65regulation of postsynaptic membrane potential (GO:0060078)3.24853035
66positive regulation of neurotransmitter secretion (GO:0001956)3.24057032
67regulation of neurotransmitter transport (GO:0051588)3.23214584
68cerebellar granule cell differentiation (GO:0021707)3.22302197
69positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.22292098
70proline transport (GO:0015824)3.20339282
71establishment of synaptic vesicle localization (GO:0097480)3.19606973
72synaptic vesicle transport (GO:0048489)3.19606973
73neuronal action potential (GO:0019228)3.17588789
74transmission of nerve impulse (GO:0019226)3.17189702
75gamma-aminobutyric acid transport (GO:0015812)3.15574306
76regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.14894631
77synaptic vesicle endocytosis (GO:0048488)3.10485332
78regulation of neurotransmitter levels (GO:0001505)3.09821336
79regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.09033416
80negative regulation of cytosolic calcium ion concentration (GO:0051481)3.08957156
81ketone body metabolic process (GO:1902224)3.08797647
82positive regulation of synapse assembly (GO:0051965)3.07792428
83activation of protein kinase A activity (GO:0034199)3.06819850
84G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.06817095
85regulation of voltage-gated calcium channel activity (GO:1901385)3.05870818
86positive regulation of neurotransmitter transport (GO:0051590)3.05678448
87negative regulation of neurotransmitter transport (GO:0051589)3.04655025
88reflex (GO:0060004)3.04542048
89cellular potassium ion homeostasis (GO:0030007)3.04146729
90regulation of synaptic transmission, glutamatergic (GO:0051966)3.03888583
91regulation of dendritic spine development (GO:0060998)3.03425893
92negative regulation of dendrite morphogenesis (GO:0050774)3.02960190
93mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.02423597
94behavioral response to ethanol (GO:0048149)3.00851082
95serotonin metabolic process (GO:0042428)2.99987034
96indole-containing compound metabolic process (GO:0042430)2.98485251
97positive regulation of synapse maturation (GO:0090129)2.96045981
98chaperone-mediated protein transport (GO:0072321)2.95438937
99regulation of glutamate secretion (GO:0014048)2.95265568
100positive regulation of synaptic transmission (GO:0050806)2.93248316
101cellular biogenic amine catabolic process (GO:0042402)2.91995845
102amine catabolic process (GO:0009310)2.91995845
103primary amino compound metabolic process (GO:1901160)2.91883176
104innervation (GO:0060384)2.90309414
105cAMP catabolic process (GO:0006198)2.90205562
106epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.90096076
107behavioral fear response (GO:0001662)2.89327159
108behavioral defense response (GO:0002209)2.89327159
109membrane depolarization during action potential (GO:0086010)2.89192852
110synapse assembly (GO:0007416)2.89044899
111regulation of synaptic transmission (GO:0050804)2.88996604
112positive regulation of synaptic transmission, GABAergic (GO:0032230)2.88104237
113positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.87753373
114regulation of sarcomere organization (GO:0060297)2.87409946
115negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.86527901
116synaptic transmission (GO:0007268)2.85867415
117regulation of synaptic transmission, GABAergic (GO:0032228)2.85661139
118regulation of action potential (GO:0098900)2.85161294
119G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.84538360
120positive regulation of dendritic spine development (GO:0060999)2.81565623
121learning (GO:0007612)2.80587559
122regulation of respiratory system process (GO:0044065)2.80404366
123dendrite morphogenesis (GO:0048813)2.80403486
124detection of calcium ion (GO:0005513)2.80236239
125auditory behavior (GO:0031223)2.78527522
126protein targeting to Golgi (GO:0000042)2.77635274
127fear response (GO:0042596)2.77122618
128establishment of vesicle localization (GO:0051650)2.76381999
129protein K63-linked deubiquitination (GO:0070536)2.76145764
130startle response (GO:0001964)2.75176160
131synapse organization (GO:0050808)2.74752157
132regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.73982681
133calcium ion-dependent exocytosis (GO:0017156)2.73920514
134negative regulation of dendrite development (GO:2000171)2.73157717
135nonmotile primary cilium assembly (GO:0035058)2.73152935
136mating behavior (GO:0007617)2.72847312
137pyrimidine nucleobase catabolic process (GO:0006208)2.72771590
138interkinetic nuclear migration (GO:0022027)2.72309081
139behavioral response to cocaine (GO:0048148)2.72107074
140axoneme assembly (GO:0035082)2.71271945
141protein K11-linked deubiquitination (GO:0035871)2.69858035
142cyclic nucleotide catabolic process (GO:0009214)2.68151335
143regulation of skeletal muscle contraction (GO:0014819)2.67386675
144negative regulation of mast cell activation (GO:0033004)2.66968444
145retinal cone cell development (GO:0046549)2.66281696
146synaptic transmission, cholinergic (GO:0007271)2.65651564
147retrograde transport, vesicle recycling within Golgi (GO:0000301)2.63264039
148auditory receptor cell stereocilium organization (GO:0060088)2.61899911
149regulation of meiosis I (GO:0060631)2.55894354
150photoreceptor cell development (GO:0042461)2.54767786
151epithelial cilium movement (GO:0003351)2.54350439
152dopamine transport (GO:0015872)2.54022806
153detection of mechanical stimulus involved in sensory perception (GO:0050974)2.53724849
154protein localization to Golgi apparatus (GO:0034067)2.51053993
155cilium morphogenesis (GO:0060271)2.50581485
156mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.50080850
157mitochondrial respiratory chain complex I assembly (GO:0032981)2.50080850
158NADH dehydrogenase complex assembly (GO:0010257)2.50080850
159positive regulation of meiosis (GO:0045836)2.49198214
160water-soluble vitamin biosynthetic process (GO:0042364)2.47773278
161parturition (GO:0007567)2.47438530
162signal peptide processing (GO:0006465)2.46601457
163tachykinin receptor signaling pathway (GO:0007217)2.46273803
164action potential (GO:0001508)2.45114508
165L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.43371318
166benzene-containing compound metabolic process (GO:0042537)2.42088862
167cerebellar Purkinje cell differentiation (GO:0021702)2.38574174
168protein complex biogenesis (GO:0070271)2.38530717
169somite development (GO:0061053)2.38249162
170nucleobase catabolic process (GO:0046113)2.36238754
171negative regulation of systemic arterial blood pressure (GO:0003085)2.35865437
172C4-dicarboxylate transport (GO:0015740)2.35772380
173eye photoreceptor cell development (GO:0042462)2.34436146
174replication fork processing (GO:0031297)2.33378533
175endoderm formation (GO:0001706)2.33108278
176snRNA transcription (GO:0009301)2.31406564
177centriole replication (GO:0007099)2.31221729
178inner ear receptor stereocilium organization (GO:0060122)2.30461751
179protein localization to cilium (GO:0061512)2.30219689
180positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.30177387
181cilium organization (GO:0044782)2.29861711
182regulation of rhodopsin mediated signaling pathway (GO:0022400)2.29317715
183positive regulation of meiotic cell cycle (GO:0051446)2.28843794
184platelet dense granule organization (GO:0060155)2.27218151
185sulfation (GO:0051923)2.25069059
186cilium assembly (GO:0042384)2.25050611
187rhodopsin mediated signaling pathway (GO:0016056)2.24778282
188piRNA metabolic process (GO:0034587)2.24772936

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.95774750
2GBX2_23144817_ChIP-Seq_PC3_Human4.01201802
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.36984361
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.30889784
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.27812715
6VDR_22108803_ChIP-Seq_LS180_Human3.12223968
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.84729860
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.77636332
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.77636332
10* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.69982128
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.69661612
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.69177749
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.68632871
14* REST_21632747_ChIP-Seq_MESCs_Mouse2.68245592
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.64197576
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.56810577
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.50136802
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.48805493
19TAF15_26573619_Chip-Seq_HEK293_Human2.38133987
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.35398723
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.23996032
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.21633438
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.18299633
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.17509251
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.13787403
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06361086
27FLI1_27457419_Chip-Seq_LIVER_Mouse2.06317028
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.03277348
29AR_21572438_ChIP-Seq_LNCaP_Human1.85162610
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.84299509
31DROSHA_22980978_ChIP-Seq_HELA_Human1.79916698
32P300_19829295_ChIP-Seq_ESCs_Human1.79908681
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.79863006
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78523273
35OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75777249
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.74221923
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.73354590
38* SMAD4_21799915_ChIP-Seq_A2780_Human1.72115354
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71379603
40NR3C1_23031785_ChIP-Seq_PC12_Mouse1.70592823
41FUS_26573619_Chip-Seq_HEK293_Human1.68860592
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68195265
43RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67140476
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66837512
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66570183
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65142422
47ZNF274_21170338_ChIP-Seq_K562_Hela1.62209721
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62156312
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56848680
50SALL1_21062744_ChIP-ChIP_HESCs_Human1.56221541
51IGF1R_20145208_ChIP-Seq_DFB_Human1.54822814
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52136071
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48980712
54CBP_20019798_ChIP-Seq_JUKART_Human1.48980712
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47581871
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.47218211
57ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.46109161
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45563151
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45241579
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45241579
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44203395
62* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43872281
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.43819068
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42537996
65* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42328810
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41434227
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40912688
68BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38667464
69AR_25329375_ChIP-Seq_VCAP_Human1.35436956
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.35226043
71ER_23166858_ChIP-Seq_MCF-7_Human1.33506366
72JUN_21703547_ChIP-Seq_K562_Human1.31694430
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.31394099
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31085265
75* SOX2_21211035_ChIP-Seq_LN229_Gbm1.30191299
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28816215
77RNF2_27304074_Chip-Seq_NSC_Mouse1.28653830
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28456142
79IRF1_19129219_ChIP-ChIP_H3396_Human1.22965936
80TP53_22573176_ChIP-Seq_HFKS_Human1.22601965
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.22546710
82RING1B_27294783_Chip-Seq_ESCs_Mouse1.22203324
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22135267
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20319368
85TCF4_22108803_ChIP-Seq_LS180_Human1.19316700
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19019871
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18951184
88ERG_21242973_ChIP-ChIP_JURKAT_Human1.18838417
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18807331
90* STAT3_23295773_ChIP-Seq_U87_Human1.18769155
91RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17118549
92* NANOG_19829295_ChIP-Seq_ESCs_Human1.16067261
93* SOX2_19829295_ChIP-Seq_ESCs_Human1.16067261
94P53_22387025_ChIP-Seq_ESCs_Mouse1.15212116
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14080884
96EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13453687
97CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12127404
98CRX_20693478_ChIP-Seq_RETINA_Mouse1.11144831
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10951844
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.10836730
101SMAD4_21741376_ChIP-Seq_EPCs_Human1.10544818
102P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09875434
103ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09718482
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07745421
105E2F1_18555785_Chip-Seq_ESCs_Mouse1.07391835
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05139206
107TP53_18474530_ChIP-ChIP_U2OS_Human1.04022583
108TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03734155
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03518537
110* RUNX2_22187159_ChIP-Seq_PCA_Human1.03239085
111CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02560520
112YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02517192
113FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02427194
114STAT3_18555785_Chip-Seq_ESCs_Mouse1.01570942
115TCF4_23295773_ChIP-Seq_U87_Human1.01261693
116OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01235712
117E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00408980
118TAL1_26923725_Chip-Seq_HPCs_Mouse1.00281633
119NOTCH1_21737748_ChIP-Seq_TLL_Human0.99417303
120EWS_26573619_Chip-Seq_HEK293_Human0.98719275
121FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98362071
122WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97829122
123FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97823733
124FOXA1_25329375_ChIP-Seq_VCAP_Human0.97823733
125SOX9_26525672_Chip-Seq_HEART_Mouse0.97061530
126AR_19668381_ChIP-Seq_PC3_Human0.96994497
127NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96466661
128RING1B_27294783_Chip-Seq_NPCs_Mouse0.96271510
129CMYC_18555785_Chip-Seq_ESCs_Mouse0.95844193
130AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95359399
131RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95325032
132* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95171300
133WT1_19549856_ChIP-ChIP_CCG9911_Human0.94810375
134GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94168777
135* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92992396
136* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92992396
137* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92121380
138SMAD3_21741376_ChIP-Seq_ESCs_Human0.91785120
139DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90876865
140EP300_21415370_ChIP-Seq_HL-1_Mouse0.90470008
141BCAT_22108803_ChIP-Seq_LS180_Human0.90048214
142NANOG_18555785_Chip-Seq_ESCs_Mouse0.88021890
143FLI1_21867929_ChIP-Seq_TH2_Mouse0.87905960
144TP53_16413492_ChIP-PET_HCT116_Human0.87726481
145CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87621128
146TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87603199

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.03362489
2MP0003880_abnormal_central_pattern5.18795129
3MP0003635_abnormal_synaptic_transmissio4.05718752
4MP0000569_abnormal_digit_pigmentation4.02915934
5MP0004270_analgesia3.41876274
6MP0009745_abnormal_behavioral_response3.30533408
7MP0002063_abnormal_learning/memory/cond3.21331715
8MP0002064_seizures3.18008764
9MP0001968_abnormal_touch/_nociception3.08214155
10MP0009046_muscle_twitch2.86048115
11MP0002736_abnormal_nociception_after2.65849745
12MP0002572_abnormal_emotion/affect_behav2.65216932
13MP0002272_abnormal_nervous_system2.63987718
14MP0002734_abnormal_mechanical_nocicepti2.52732654
15MP0001529_abnormal_vocalization2.35562923
16MP0003646_muscle_fatigue2.33215175
17MP0005423_abnormal_somatic_nervous2.29538631
18MP0003195_calcinosis2.26159582
19MP0002102_abnormal_ear_morphology2.20710214
20MP0001486_abnormal_startle_reflex2.19824284
21MP0003122_maternal_imprinting2.14279405
22MP0008877_abnormal_DNA_methylation2.13828425
23MP0002735_abnormal_chemical_nociception2.11854055
24MP0001986_abnormal_taste_sensitivity2.04949897
25MP0001501_abnormal_sleep_pattern2.03618059
26MP0002067_abnormal_sensory_capabilities2.00605521
27MP0006276_abnormal_autonomic_nervous2.00344857
28MP0001440_abnormal_grooming_behavior1.99967115
29MP0002733_abnormal_thermal_nociception1.97076479
30MP0003329_amyloid_beta_deposits1.95012652
31MP0001970_abnormal_pain_threshold1.87995028
32MP0000778_abnormal_nervous_system1.86081221
33MP0002822_catalepsy1.85203970
34MP0001905_abnormal_dopamine_level1.84845207
35MP0005386_behavior/neurological_phenoty1.83240994
36MP0004924_abnormal_behavior1.83240994
37MP0005646_abnormal_pituitary_gland1.83142638
38MP0002184_abnormal_innervation1.80885735
39MP0006292_abnormal_olfactory_placode1.78870328
40MP0005253_abnormal_eye_physiology1.78608108
41MP0008569_lethality_at_weaning1.70670378
42MP0004811_abnormal_neuron_physiology1.69942490
43MP0002557_abnormal_social/conspecific_i1.65239762
44MP0000372_irregular_coat_pigmentation1.65162621
45MP0002909_abnormal_adrenal_gland1.64359152
46MP0000013_abnormal_adipose_tissue1.61602998
47MP0009780_abnormal_chondrocyte_physiolo1.58734080
48MP0000955_abnormal_spinal_cord1.55556692
49MP0001188_hyperpigmentation1.50809620
50MP0005174_abnormal_tail_pigmentation1.50782966
51MP0004142_abnormal_muscle_tone1.50009334
52MP0002837_dystrophic_cardiac_calcinosis1.47010403
53MP0002066_abnormal_motor_capabilities/c1.42335259
54MP0000427_abnormal_hair_cycle1.41993701
55MP0001502_abnormal_circadian_rhythm1.41830549
56MP0002882_abnormal_neuron_morphology1.38946740
57MP0003787_abnormal_imprinting1.37667507
58MP0001984_abnormal_olfaction1.34359172
59MP0002234_abnormal_pharynx_morphology1.32140134
60MP0003633_abnormal_nervous_system1.30985181
61MP0005645_abnormal_hypothalamus_physiol1.30175555
62MP0004043_abnormal_pH_regulation1.26547143
63MP0004858_abnormal_nervous_system1.25965277
64MP0003011_delayed_dark_adaptation1.25217814
65MP0003879_abnormal_hair_cell1.25088241
66MP0004145_abnormal_muscle_electrophysio1.21474317
67MP0008995_early_reproductive_senescence1.15677105
68MP0010386_abnormal_urinary_bladder1.15276215
69MP0008775_abnormal_heart_ventricle1.11128961
70MP0002152_abnormal_brain_morphology1.10065214
71MP0004130_abnormal_muscle_cell1.06290890
72MP0003631_nervous_system_phenotype1.04875094
73MP0002928_abnormal_bile_duct1.03571585
74MP0005171_absent_coat_pigmentation1.02200227
75MP0002095_abnormal_skin_pigmentation1.01688812
76MP0000920_abnormal_myelination1.00547425
77MP0005389_reproductive_system_phenotype0.99862642
78MP0001177_atelectasis0.97881863
79MP0005551_abnormal_eye_electrophysiolog0.97044435
80MP0000631_abnormal_neuroendocrine_gland0.95397061
81MP0004885_abnormal_endolymph0.95093832
82MP0000230_abnormal_systemic_arterial0.93931133
83MP0002229_neurodegeneration0.92744813
84MP0002160_abnormal_reproductive_system0.91966188
85MP0005084_abnormal_gallbladder_morpholo0.91078608
86MP0003252_abnormal_bile_duct0.90989899
87MP0002163_abnormal_gland_morphology0.89561356
88MP0000751_myopathy0.88399761
89MP0003634_abnormal_glial_cell0.87786103
90MP0003121_genomic_imprinting0.87277479
91MP0004215_abnormal_myocardial_fiber0.86356750
92MP0002638_abnormal_pupillary_reflex0.85816301
93MP0002069_abnormal_eating/drinking_beha0.85697792
94MP0008875_abnormal_xenobiotic_pharmacok0.85488427
95MP0005670_abnormal_white_adipose0.85419272
96MP0004085_abnormal_heartbeat0.84648736
97MP0000015_abnormal_ear_pigmentation0.84105916
98MP0002938_white_spotting0.83161424
99MP0005195_abnormal_posterior_eye0.82936872
100MP0000383_abnormal_hair_follicle0.81582335
101MP0005623_abnormal_meninges_morphology0.81188681
102MP0005535_abnormal_body_temperature0.80143088
103MP0008057_abnormal_DNA_replication0.79902917
104MP0004742_abnormal_vestibular_system0.79872831
105MP0003123_paternal_imprinting0.79724020
106MP0003890_abnormal_embryonic-extraembry0.79474584
107MP0001963_abnormal_hearing_physiology0.77967976
108MP0001919_abnormal_reproductive_system0.77825363
109MP0001299_abnormal_eye_distance/0.77161466
110MP0002138_abnormal_hepatobiliary_system0.76988246
111MP0002090_abnormal_vision0.75151790
112MP0001664_abnormal_digestion0.72341707
113MP0002752_abnormal_somatic_nervous0.72102262
114MP0006072_abnormal_retinal_apoptosis0.71794011
115MP0005266_abnormal_metabolism0.71436764
116MP0003698_abnormal_male_reproductive0.71393381
117MP0000026_abnormal_inner_ear0.70137555
118MP0003137_abnormal_impulse_conducting0.70125120
119MP0003136_yellow_coat_color0.70027635
120MP0004084_abnormal_cardiac_muscle0.69798953
121MP0004147_increased_porphyrin_level0.65648232
122MP0000604_amyloidosis0.64904064
123MP0001943_abnormal_respiration0.64241849
124MP0001485_abnormal_pinna_reflex0.63851205
125MP0008872_abnormal_physiological_respon0.60737969
126MP0005187_abnormal_penis_morphology0.59713919
127MP0008961_abnormal_basal_metabolism0.59331033
128MP0005409_darkened_coat_color0.58732737
129MP0002751_abnormal_autonomic_nervous0.58352305
130MP0003632_abnormal_nervous_system0.56653730
131MP0004036_abnormal_muscle_relaxation0.56467243
132MP0000747_muscle_weakness0.55914700
133MP0005620_abnormal_muscle_contractility0.54897831
134MP0004484_altered_response_of0.54859331
135MP0002876_abnormal_thyroid_physiology0.53553352
136MP0008874_decreased_physiological_sensi0.52901463
137MP0003956_abnormal_body_size0.52515187
138MP0003861_abnormal_nervous_system0.51085211
139MP0003075_altered_response_to0.50624621
140MP0010770_preweaning_lethality0.50124698

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.68061912
2Myokymia (HP:0002411)5.80300128
3Visual hallucinations (HP:0002367)5.12394744
4Focal seizures (HP:0007359)4.95303113
5Epileptic encephalopathy (HP:0200134)4.63703580
6Pancreatic cysts (HP:0001737)4.49489438
7Atonic seizures (HP:0010819)4.35133752
8Pancreatic fibrosis (HP:0100732)4.16411537
9Abnormality of midbrain morphology (HP:0002418)4.12960035
10Molar tooth sign on MRI (HP:0002419)4.12960035
11Hyperventilation (HP:0002883)3.98836037
12True hermaphroditism (HP:0010459)3.96074025
13Congenital stationary night blindness (HP:0007642)3.95246252
14Absence seizures (HP:0002121)3.94416584
15Generalized tonic-clonic seizures (HP:0002069)3.67769604
16Dialeptic seizures (HP:0011146)3.57949460
17Pheochromocytoma (HP:0002666)3.47536566
18Abnormality of the renal cortex (HP:0011035)3.44737904
19Progressive cerebellar ataxia (HP:0002073)3.42302281
20Broad-based gait (HP:0002136)3.37073006
21Neuroendocrine neoplasm (HP:0100634)3.34342484
22Nephronophthisis (HP:0000090)3.32962501
23Febrile seizures (HP:0002373)3.31069330
24Anxiety (HP:0000739)3.19608778
25Supranuclear gaze palsy (HP:0000605)3.16629142
26Abnormality of the renal medulla (HP:0100957)3.12408323
27Amblyopia (HP:0000646)3.10595029
28Papilledema (HP:0001085)3.09495634
29Medial flaring of the eyebrow (HP:0010747)3.04988775
30Chronic hepatic failure (HP:0100626)3.02569905
31Ankle clonus (HP:0011448)3.00850173
32Depression (HP:0000716)2.98074423
33Poor eye contact (HP:0000817)2.92250405
34Progressive inability to walk (HP:0002505)2.91970806
35Impaired vibration sensation in the lower limbs (HP:0002166)2.89368287
36Limb dystonia (HP:0002451)2.87924591
37Abolished electroretinogram (ERG) (HP:0000550)2.84364948
38Truncal ataxia (HP:0002078)2.83662645
39Cystic liver disease (HP:0006706)2.77722376
40Retinal dysplasia (HP:0007973)2.77480857
41Dysmetria (HP:0001310)2.76618492
42Abnormal eating behavior (HP:0100738)2.75113756
43Acute necrotizing encephalopathy (HP:0006965)2.74679096
44Gaze-evoked nystagmus (HP:0000640)2.66258952
45Scanning speech (HP:0002168)2.65954166
46Attenuation of retinal blood vessels (HP:0007843)2.64650465
47Abnormal mitochondria in muscle tissue (HP:0008316)2.64210069
48Dysdiadochokinesis (HP:0002075)2.63418134
49Excessive salivation (HP:0003781)2.61130620
50Drooling (HP:0002307)2.61130620
51Abnormal biliary tract physiology (HP:0012439)2.60951507
52Bile duct proliferation (HP:0001408)2.60951507
53Megalencephaly (HP:0001355)2.59898668
54Urinary urgency (HP:0000012)2.55835849
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.53924160
56Abnormality of alanine metabolism (HP:0010916)2.53924160
57Hyperalaninemia (HP:0003348)2.53924160
58Progressive macrocephaly (HP:0004481)2.48405406
59Insidious onset (HP:0003587)2.47580019
60Termporal pattern (HP:0011008)2.47580019
61Abnormal drinking behavior (HP:0030082)2.46916488
62Polydipsia (HP:0001959)2.46916488
63Epileptiform EEG discharges (HP:0011182)2.45646008
64Inability to walk (HP:0002540)2.44604647
65Renal cortical cysts (HP:0000803)2.43123812
66Agitation (HP:0000713)2.42185966
67Impaired social interactions (HP:0000735)2.40957469
68Abnormal social behavior (HP:0012433)2.40957469
69Abnormal rod and cone electroretinograms (HP:0008323)2.38968443
70Mutism (HP:0002300)2.38459551
71Nephrogenic diabetes insipidus (HP:0009806)2.36748427
72Spastic gait (HP:0002064)2.35499275
73Tubular atrophy (HP:0000092)2.35344240
74EEG with generalized epileptiform discharges (HP:0011198)2.32450695
75Action tremor (HP:0002345)2.31559746
76Delusions (HP:0000746)2.28673119
77Type II lissencephaly (HP:0007260)2.28340188
78Neoplasm of the peripheral nervous system (HP:0100007)2.27873162
79Neurofibrillary tangles (HP:0002185)2.27854205
80Focal dystonia (HP:0004373)2.27501786
81Absent rod-and cone-mediated responses on ERG (HP:0007688)2.27312924
82Torticollis (HP:0000473)2.24624151
83Cerebral inclusion bodies (HP:0100314)2.24066927
84Mitochondrial inheritance (HP:0001427)2.22844292
85Congenital hepatic fibrosis (HP:0002612)2.22581084
86Protruding tongue (HP:0010808)2.20444827
87Stomach cancer (HP:0012126)2.19411423
88Furrowed tongue (HP:0000221)2.17543632
89Anencephaly (HP:0002323)2.17190868
90Generalized myoclonic seizures (HP:0002123)2.17171183
91Urinary bladder sphincter dysfunction (HP:0002839)2.17064508
92Hypsarrhythmia (HP:0002521)2.16565048
93Fair hair (HP:0002286)2.16536330
94Polyuria (HP:0000103)2.15786446
95Decreased central vision (HP:0007663)2.15244362
96Blue irides (HP:0000635)2.14986066
97Absent speech (HP:0001344)2.14614360
98Diplopia (HP:0000651)2.13923753
99Abnormality of binocular vision (HP:0011514)2.13923753
100Gait imbalance (HP:0002141)2.13790058
101Congenital sensorineural hearing impairment (HP:0008527)2.13317529
102Stereotypic behavior (HP:0000733)2.12041440
103Aplasia/Hypoplasia of the tibia (HP:0005772)2.11861455
104Aplasia/Hypoplasia of the tongue (HP:0010295)2.11700433
105Male pseudohermaphroditism (HP:0000037)2.10475110
106Abnormality of glycolysis (HP:0004366)2.10287290
107Increased serum pyruvate (HP:0003542)2.10287290
108Acute encephalopathy (HP:0006846)2.09883336
109Sclerocornea (HP:0000647)2.07714685
110Abnormal hair whorl (HP:0010721)2.06229193
111Craniofacial dystonia (HP:0012179)2.05649838
112Lissencephaly (HP:0001339)2.05110189
113Fetal akinesia sequence (HP:0001989)2.03529558
114Polyphagia (HP:0002591)2.03440893
115Oligodactyly (hands) (HP:0001180)2.02679328
116Postaxial foot polydactyly (HP:0001830)2.01317430
117Degeneration of the lateral corticospinal tracts (HP:0002314)2.00397437
118Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.00397437
119Failure to thrive in infancy (HP:0001531)1.99710157
120Pendular nystagmus (HP:0012043)1.99662748
121Keratoconus (HP:0000563)1.99297775
122Increased corneal curvature (HP:0100692)1.99297775
123Genital tract atresia (HP:0001827)1.98301296
124Abnormality of the corticospinal tract (HP:0002492)1.97329147
125Clumsiness (HP:0002312)1.97165494
126Bradykinesia (HP:0002067)1.96453928
127Vaginal atresia (HP:0000148)1.96152903
128Widely spaced teeth (HP:0000687)1.96136117
129Amyotrophic lateral sclerosis (HP:0007354)1.96069798
130Thickened helices (HP:0000391)1.96036682
131Menstrual irregularities (HP:0000858)1.91521164
132Central scotoma (HP:0000603)1.90626567
133Cerebellar dysplasia (HP:0007033)1.88594012
134Congenital primary aphakia (HP:0007707)1.87586575
135Hemiparesis (HP:0001269)1.87424785
136Psychosis (HP:0000709)1.86735130
137Hypoplastic ischia (HP:0003175)1.86252787
138Impaired vibratory sensation (HP:0002495)1.85193158
139Esotropia (HP:0000565)1.84365670
140Lower limb muscle weakness (HP:0007340)1.84130851
141Poor suck (HP:0002033)1.83215897
142Hepatocellular necrosis (HP:0001404)1.82863805
143Postural instability (HP:0002172)1.82284778
144Deep palmar crease (HP:0006191)1.81962023
145Increased CSF lactate (HP:0002490)1.81796521
146Bony spicule pigmentary retinopathy (HP:0007737)1.80910628
147Hypoventilation (HP:0002791)1.80716034
148Unsteady gait (HP:0002317)1.79590229
149Incomplete penetrance (HP:0003829)1.79412109
150Tubulointerstitial abnormality (HP:0001969)1.78724840
151Poor coordination (HP:0002370)1.78691189
152Congenital, generalized hypertrichosis (HP:0004540)1.78272154
153Left ventricular hypertrophy (HP:0001712)1.78143477
154Decreased electroretinogram (ERG) amplitude (HP:0000654)1.77733427
155Genetic anticipation (HP:0003743)1.77237501
156Pachygyria (HP:0001302)1.77200832
157Generalized hypopigmentation of hair (HP:0011358)1.72867490
158Hepatic necrosis (HP:0002605)1.71320958
159Abnormality of macular pigmentation (HP:0008002)1.70944675
160Thyroiditis (HP:0100646)1.70218330
161Tachypnea (HP:0002789)1.69266590
162Decreased circulating renin level (HP:0003351)1.68024137
163Abnormality of the ischium (HP:0003174)1.67895986
164Hypothermia (HP:0002045)1.67438909
1653-Methylglutaconic aciduria (HP:0003535)1.67382357
166Abnormal urine output (HP:0012590)1.65869503
167Chorioretinal atrophy (HP:0000533)1.65247039
168Optic disc pallor (HP:0000543)1.64698995
169Dyskinesia (HP:0100660)1.64584011
170Postaxial hand polydactyly (HP:0001162)1.64409110

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.23113597
2NTRK33.95560314
3EPHA43.62666307
4MAP3K123.61857218
5MAP3K93.36509647
6MINK13.00338946
7ADRBK22.94565778
8ACVR1B2.90741093
9MAP3K42.73142051
10MARK12.69316158
11MAP2K72.67145562
12MAP4K22.51874371
13CASK2.50770411
14CDK192.43192027
15NUAK12.39705456
16WNK32.29449171
17TAOK32.28818996
18ARAF2.26274296
19GRK12.22095540
20KSR22.09623773
21DAPK22.05918560
22PAK62.05269652
23KSR12.00655835
24PLK21.97301360
25MAP2K41.92821145
26RIPK41.80941182
27INSRR1.75355650
28OBSCN1.67174694
29CAMKK21.65758237
30DAPK11.60891781
31ZAK1.59271550
32SIK31.55388129
33CAMKK11.55049445
34NTRK11.49554729
35NTRK21.47461543
36CDK51.45087828
37TXK1.44145924
38UHMK11.43299904
39LIMK11.39630615
40TLK11.37270509
41OXSR11.32029362
42PRKD31.29650311
43BMPR21.24815119
44WNK41.24692974
45GRK51.23178342
46FES1.20235818
47PRPF4B1.20223757
48MAPK131.20113413
49RAF11.19829937
50NME11.15379386
51MAP3K131.15135201
52TNIK1.13696333
53CDK141.12872539
54PRKCG1.12385817
55MKNK21.11009310
56PAK31.09369293
57CAMK2A1.09243314
58BCR1.08469693
59CDK181.06888594
60CAMK2B1.05728034
61PIK3CA0.99710043
62CDK150.99064775
63AKT30.98509943
64PIK3CG0.98473854
65PNCK0.95574947
66MAP3K20.94681769
67TEC0.93994528
68CCNB10.91037066
69SCYL20.89609364
70PTK2B0.87316045
71BRAF0.86452205
72CDK11A0.86348235
73TYRO30.85132974
74CSNK1G20.84991537
75SGK2230.81425931
76SGK4940.81425931
77SIK20.79983301
78MAP2K60.79053353
79PDK20.75407924
80TIE10.73937406
81LATS20.72260727
82CAMK10.70993153
83PKN10.70357307
84MOS0.69848317
85STK38L0.68232603
86RET0.67504032
87MAPKAPK50.65914508
88ERBB30.65382950
89PRKCH0.65121499
90BMPR1B0.64891565
91CAMK2G0.63553326
92TGFBR10.63262685
93DYRK20.63173069
94STK390.61219666
95TRIM280.60135345
96CAMK2D0.59716938
97MAP3K10.59372854
98TESK10.59372145
99MAP2K10.58283124
100DAPK30.57880725
101IKBKB0.56732994
102PRKCE0.56356542
103BRSK10.56101785
104PINK10.55627491
105TESK20.54914066
106ROCK20.53563697
107FGFR20.53418664
108IRAK10.52860016
109DYRK1A0.52743396
110PLK40.52592952
111CSNK1G30.51900550
112TAOK10.51659408
113RPS6KA50.51541697
114PRKACA0.50205121
115TRPM70.49306294
116PHKG20.49054570
117PHKG10.49054570
118SYK0.48985773
119STK30.48931852
120CHUK0.48756438
121STK160.48643398
122STK110.48140738
123TNK20.47278782
124KIT0.45627988
125CDK30.45146474
126PRKG10.44239608
127CSNK1G10.44125498
128BCKDK0.43475770
129ERBB20.43303749
130PDK10.43123070
131ITK0.42852567
132FER0.41874843
133GRK70.41187523
134CSNK1D0.41139223
135SGK10.41084368
136PDPK10.40585925
137MAPK120.40369620
138SGK20.40140480
139IKBKE0.39220110
140KDR0.38709980
141PRKAA10.37754194
142MARK30.37444008
143MUSK0.37441174
144STK380.37166191
145WNK10.37084751
146VRK10.35860511
147FYN0.32583554
148MARK20.32241911
149ROCK10.31521246
150CSNK1A1L0.31279674
151PRKCQ0.29830560
152ERBB40.29269457
153ADRBK10.28944505

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.45200258
2Synaptic vesicle cycle_Homo sapiens_hsa047213.36075230
3Long-term potentiation_Homo sapiens_hsa047202.75614768
4Circadian entrainment_Homo sapiens_hsa047132.67155278
5GABAergic synapse_Homo sapiens_hsa047272.67118028
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.64807463
7Amphetamine addiction_Homo sapiens_hsa050312.52105890
8Nitrogen metabolism_Homo sapiens_hsa009102.46638389
9Morphine addiction_Homo sapiens_hsa050322.41922073
10Glutamatergic synapse_Homo sapiens_hsa047242.40742677
11Olfactory transduction_Homo sapiens_hsa047402.38270650
12Dopaminergic synapse_Homo sapiens_hsa047282.33660317
13Linoleic acid metabolism_Homo sapiens_hsa005912.23213438
14Butanoate metabolism_Homo sapiens_hsa006502.18532507
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.12282987
16Insulin secretion_Homo sapiens_hsa049112.03278447
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.94409864
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.92119016
19Collecting duct acid secretion_Homo sapiens_hsa049661.90617707
20Salivary secretion_Homo sapiens_hsa049701.88890724
21Long-term depression_Homo sapiens_hsa047301.88351181
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.86183554
23Serotonergic synapse_Homo sapiens_hsa047261.85440751
24Cholinergic synapse_Homo sapiens_hsa047251.83175742
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.81740033
26Oxidative phosphorylation_Homo sapiens_hsa001901.80058359
27Cocaine addiction_Homo sapiens_hsa050301.76323559
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.76100257
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.73007058
30Vibrio cholerae infection_Homo sapiens_hsa051101.66233802
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65290376
32Gastric acid secretion_Homo sapiens_hsa049711.62920735
33Renin secretion_Homo sapiens_hsa049241.62749268
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58285977
35Parkinsons disease_Homo sapiens_hsa050121.57019960
36Oxytocin signaling pathway_Homo sapiens_hsa049211.56166533
37Taste transduction_Homo sapiens_hsa047421.51970418
38Ether lipid metabolism_Homo sapiens_hsa005651.51692587
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48185081
40Alzheimers disease_Homo sapiens_hsa050101.47034966
41Cardiac muscle contraction_Homo sapiens_hsa042601.45191675
42Gap junction_Homo sapiens_hsa045401.42575932
43Homologous recombination_Homo sapiens_hsa034401.40700153
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.39881917
45Fanconi anemia pathway_Homo sapiens_hsa034601.34780076
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.34388470
47Tryptophan metabolism_Homo sapiens_hsa003801.34151032
48Propanoate metabolism_Homo sapiens_hsa006401.32895247
49Calcium signaling pathway_Homo sapiens_hsa040201.32166055
50GnRH signaling pathway_Homo sapiens_hsa049121.26195989
51Caffeine metabolism_Homo sapiens_hsa002321.21188257
52Axon guidance_Homo sapiens_hsa043601.20790506
53Maturity onset diabetes of the young_Homo sapiens_hsa049501.19960279
54Selenocompound metabolism_Homo sapiens_hsa004501.15486984
55Steroid hormone biosynthesis_Homo sapiens_hsa001401.13290256
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12915979
57Asthma_Homo sapiens_hsa053101.12034248
58cAMP signaling pathway_Homo sapiens_hsa040241.10154503
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09418641
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09271370
61Glioma_Homo sapiens_hsa052141.09059502
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08639595
63ABC transporters_Homo sapiens_hsa020101.08122063
64SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05499626
65RNA degradation_Homo sapiens_hsa030181.05179310
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03456407
67Estrogen signaling pathway_Homo sapiens_hsa049151.02963375
68Oocyte meiosis_Homo sapiens_hsa041141.00736394
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00054903
70RNA polymerase_Homo sapiens_hsa030200.98217510
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97180955
72Phototransduction_Homo sapiens_hsa047440.97009006
73Melanogenesis_Homo sapiens_hsa049160.96988697
74Huntingtons disease_Homo sapiens_hsa050160.96273253
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.95594776
76Chemical carcinogenesis_Homo sapiens_hsa052040.94411331
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94394519
78Basal transcription factors_Homo sapiens_hsa030220.91844479
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90007607
80Graft-versus-host disease_Homo sapiens_hsa053320.89431038
81ErbB signaling pathway_Homo sapiens_hsa040120.87906842
82Peroxisome_Homo sapiens_hsa041460.86595779
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86462881
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84692014
85Protein export_Homo sapiens_hsa030600.82161890
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81918049
87Retinol metabolism_Homo sapiens_hsa008300.77401877
88Primary immunodeficiency_Homo sapiens_hsa053400.77016259
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75914227
90Ovarian steroidogenesis_Homo sapiens_hsa049130.75792522
91Thyroid hormone synthesis_Homo sapiens_hsa049180.73790622
92Arachidonic acid metabolism_Homo sapiens_hsa005900.73216327
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72447761
94Autoimmune thyroid disease_Homo sapiens_hsa053200.69688133
95Circadian rhythm_Homo sapiens_hsa047100.67880525
96Dilated cardiomyopathy_Homo sapiens_hsa054140.67724327
97Alcoholism_Homo sapiens_hsa050340.67280263
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66562819
99Allograft rejection_Homo sapiens_hsa053300.64897920
100VEGF signaling pathway_Homo sapiens_hsa043700.63942978
101MAPK signaling pathway_Homo sapiens_hsa040100.63196451
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.62796619
103Ras signaling pathway_Homo sapiens_hsa040140.62667373
104Type II diabetes mellitus_Homo sapiens_hsa049300.62358037
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.61355680
106Pancreatic secretion_Homo sapiens_hsa049720.61148813
107Glycerolipid metabolism_Homo sapiens_hsa005610.60839086
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.60580580
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.59143871
110Glucagon signaling pathway_Homo sapiens_hsa049220.58002244
111Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57651348
112Type I diabetes mellitus_Homo sapiens_hsa049400.57064171
113Renal cell carcinoma_Homo sapiens_hsa052110.57062764
114Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56322794
115Rap1 signaling pathway_Homo sapiens_hsa040150.55527362
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55228254
117Choline metabolism in cancer_Homo sapiens_hsa052310.53034660
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52649296
119Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52363158
120Dorso-ventral axis formation_Homo sapiens_hsa043200.50242443
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49753628
122Endocytosis_Homo sapiens_hsa041440.49509946
123Rheumatoid arthritis_Homo sapiens_hsa053230.48000991
124beta-Alanine metabolism_Homo sapiens_hsa004100.47445003
125Purine metabolism_Homo sapiens_hsa002300.43272831
126Phagosome_Homo sapiens_hsa041450.42774877
127Systemic lupus erythematosus_Homo sapiens_hsa053220.42103788
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41452930
129NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40471227
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39904754
131Wnt signaling pathway_Homo sapiens_hsa043100.39672942
132Prion diseases_Homo sapiens_hsa050200.39521166
133Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39515855
134Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39132671
135Regulation of autophagy_Homo sapiens_hsa041400.37621694
136Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36913803
137Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36576689
138Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35654796
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33438346
140Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30876310
141Platelet activation_Homo sapiens_hsa046110.27817726
142Non-small cell lung cancer_Homo sapiens_hsa052230.26048395
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24590212
144Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24433223
145Chemokine signaling pathway_Homo sapiens_hsa040620.23942364
146Endometrial cancer_Homo sapiens_hsa052130.23833434
147Colorectal cancer_Homo sapiens_hsa052100.23709792
148Salmonella infection_Homo sapiens_hsa051320.23528618

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