YAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of hippo signaling (GO:0035330)4.60239070
2* paraxial mesoderm development (GO:0048339)4.00340189
3skin morphogenesis (GO:0043589)3.60193286
4adherens junction assembly (GO:0034333)3.35849364
5Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.34615338
6cell-substrate adherens junction assembly (GO:0007045)3.33751079
7focal adhesion assembly (GO:0048041)3.33751079
8cell adhesion mediated by integrin (GO:0033627)3.27323887
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.25793676
10nuclear pore complex assembly (GO:0051292)3.25227680
11dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.23764549
12regulation of posttranscriptional gene silencing (GO:0060147)3.23438693
13regulation of gene silencing by miRNA (GO:0060964)3.23438693
14regulation of gene silencing by RNA (GO:0060966)3.23438693
15negative regulation of stem cell proliferation (GO:2000647)3.21482076
16regulation of establishment of planar polarity (GO:0090175)3.20852379
17planar cell polarity pathway involved in neural tube closure (GO:0090179)3.18859614
18nuclear pore organization (GO:0006999)3.16272497
19protein retention in ER lumen (GO:0006621)3.14309535
20regulation of cardioblast differentiation (GO:0051890)3.14146864
21non-canonical Wnt signaling pathway (GO:0035567)3.12274388
22polarized epithelial cell differentiation (GO:0030859)3.10306455
23mitotic metaphase plate congression (GO:0007080)3.09157105
24* hippo signaling (GO:0035329)3.06197698
25mitotic chromosome condensation (GO:0007076)2.97256248
26endothelial cell morphogenesis (GO:0001886)2.97182437
27regulation of sister chromatid cohesion (GO:0007063)2.96111204
28mesodermal cell differentiation (GO:0048333)2.93198063
29anterior/posterior axis specification, embryo (GO:0008595)2.93132913
30Golgi transport vesicle coating (GO:0048200)2.91473051
31COPI coating of Golgi vesicle (GO:0048205)2.91473051
32retina vasculature morphogenesis in camera-type eye (GO:0061299)2.91007071
33regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.90812455
34establishment of apical/basal cell polarity (GO:0035089)2.88844109
35establishment of tissue polarity (GO:0007164)2.86834166
36establishment of planar polarity (GO:0001736)2.86834166
37* notochord development (GO:0030903)2.85904787
38regulation of transforming growth factor beta2 production (GO:0032909)2.81271522
39hemidesmosome assembly (GO:0031581)2.79360127
40histone H2A monoubiquitination (GO:0035518)2.75716079
41embryonic camera-type eye development (GO:0031076)2.75390384
42G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.74088594
43negative regulation of cartilage development (GO:0061037)2.73150849
44cytoskeletal anchoring at plasma membrane (GO:0007016)2.72230488
45regulation of mitotic spindle organization (GO:0060236)2.71881857
46regulation of spindle organization (GO:0090224)2.69831573
47positive regulation of SMAD protein import into nucleus (GO:0060391)2.66271802
48bundle of His cell to Purkinje myocyte communication (GO:0086069)2.65518612
49heterochromatin organization (GO:0070828)2.65257999
50protein localization to cell surface (GO:0034394)2.65209255
51atrioventricular valve morphogenesis (GO:0003181)2.62133682
52metaphase plate congression (GO:0051310)2.59892746
53chondrocyte proliferation (GO:0035988)2.59716534
54regulation of SMAD protein import into nucleus (GO:0060390)2.59175823
55collagen metabolic process (GO:0032963)2.58246231
56endocardial cushion development (GO:0003197)2.57228664
57kidney mesenchyme development (GO:0072074)2.55759599
58negative regulation of catenin import into nucleus (GO:0035414)2.54899876
59pre-miRNA processing (GO:0031054)2.54619952
60mesenchymal-epithelial cell signaling (GO:0060638)2.54304823
61cochlea morphogenesis (GO:0090103)2.54056039
62regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.53744180
63lung-associated mesenchyme development (GO:0060484)2.53359972
64regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.52409997
65anatomical structure regression (GO:0060033)2.52291897
66establishment or maintenance of apical/basal cell polarity (GO:0035088)2.52076066
67establishment or maintenance of bipolar cell polarity (GO:0061245)2.52076066
68desmosome organization (GO:0002934)2.49331052
69mitotic nuclear envelope disassembly (GO:0007077)2.48060845
70establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.47693666
71multicellular organismal macromolecule metabolic process (GO:0044259)2.47245675
72embryonic retina morphogenesis in camera-type eye (GO:0060059)2.46903486
73midgut development (GO:0007494)2.46754384
74bone trabecula formation (GO:0060346)2.46168407
75embryonic process involved in female pregnancy (GO:0060136)2.45975185
76muscle cell migration (GO:0014812)2.44986959
77negative regulation of chondrocyte differentiation (GO:0032331)2.44095625
78negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.42806181
79protein localization to kinetochore (GO:0034501)2.42219192
80epithelial cell-cell adhesion (GO:0090136)2.41612886
81collagen catabolic process (GO:0030574)2.41488597
82intestinal epithelial cell development (GO:0060576)2.41158523
83collagen fibril organization (GO:0030199)2.40933336
84neuron projection extension involved in neuron projection guidance (GO:1902284)2.40505269
85axon extension involved in axon guidance (GO:0048846)2.40505269
86substrate adhesion-dependent cell spreading (GO:0034446)2.40343231
87glomerular visceral epithelial cell development (GO:0072015)2.39886193
88extracellular matrix disassembly (GO:0022617)2.39517810
89sphingosine metabolic process (GO:0006670)2.39287486
90positive regulation of catenin import into nucleus (GO:0035413)2.38973932
91embryonic foregut morphogenesis (GO:0048617)2.38123045
92keratinocyte proliferation (GO:0043616)2.37478855
93metanephric mesenchyme development (GO:0072075)2.37312657
94gap junction assembly (GO:0016264)2.36991895
95regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.36709774
96gastrulation with mouth forming second (GO:0001702)2.36197276
97surfactant homeostasis (GO:0043129)2.35826846
98lateral sprouting from an epithelium (GO:0060601)2.34678169
99vascular endothelial growth factor signaling pathway (GO:0038084)2.34367543
100multicellular organismal metabolic process (GO:0044236)2.34230453
101craniofacial suture morphogenesis (GO:0097094)2.33133854
102regulation of hair follicle development (GO:0051797)2.32765779
103cell migration involved in sprouting angiogenesis (GO:0002042)2.32093871
104regulation of tight junction assembly (GO:2000810)2.31784754
105cranial suture morphogenesis (GO:0060363)2.31628691
106negative regulation of fatty acid biosynthetic process (GO:0045717)2.31455329
107regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.31120273
108* mesenchyme development (GO:0060485)2.31005356
109SMAD protein complex assembly (GO:0007183)2.30795179
110plasma membrane repair (GO:0001778)2.30060805
111male genitalia development (GO:0030539)2.29748395
112regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.29748056
113membrane disassembly (GO:0030397)2.29288847
114nuclear envelope disassembly (GO:0051081)2.29288847
115basement membrane organization (GO:0071711)2.27253343
116cell junction assembly (GO:0034329)2.26536493
117cardiac myofibril assembly (GO:0055003)2.26462600
118outer ear morphogenesis (GO:0042473)2.26422971
119mitotic sister chromatid cohesion (GO:0007064)2.26299267
120wound healing, spreading of epidermal cells (GO:0035313)2.25922839
121establishment or maintenance of monopolar cell polarity (GO:0061339)2.25685216
122establishment of monopolar cell polarity (GO:0061162)2.25685216
123negative regulation of keratinocyte proliferation (GO:0010839)2.25423614
124apical protein localization (GO:0045176)2.25036277
125positive regulation of epithelial to mesenchymal transition (GO:0010718)2.24098434
126cell migration involved in gastrulation (GO:0042074)2.23858315
127morphogenesis of an epithelial fold (GO:0060571)2.23795042
128fibroblast migration (GO:0010761)2.23748322
129pore complex assembly (GO:0046931)2.23725324
130chondrocyte development (GO:0002063)2.23438167
131cell-substrate junction assembly (GO:0007044)2.23067162
132protein heterotrimerization (GO:0070208)2.22796555
133positive regulation of fatty acid beta-oxidation (GO:0032000)2.22663221
134glomerular basement membrane development (GO:0032836)2.22652139
135negative regulation of embryonic development (GO:0045992)2.21873875
136dorsal/ventral axis specification (GO:0009950)2.20522473
137negative regulation of cell fate specification (GO:0009996)2.20048086
138negative regulation of DNA repair (GO:0045738)2.19185266
139mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.19014025
140branching involved in salivary gland morphogenesis (GO:0060445)2.18721212
141regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.18188311
142DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.17949962
143cell surface receptor signaling pathway involved in heart development (GO:0061311)2.17370177
144regulation of heart morphogenesis (GO:2000826)2.17300783
145regulation of catenin import into nucleus (GO:0035412)2.16869871
146negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.16843578
147ventricular cardiac muscle cell development (GO:0055015)2.16256980
148regulation of RNA export from nucleus (GO:0046831)2.14635685
149monoubiquitinated protein deubiquitination (GO:0035520)2.14562516
150convergent extension (GO:0060026)2.13908614
151positive regulation of mitotic sister chromatid separation (GO:1901970)2.13828306
152positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.13828306
153positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.13828306
154organ induction (GO:0001759)2.13506698
155endodermal cell differentiation (GO:0035987)2.12800608

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.01594310
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.38044612
3E2F7_22180533_ChIP-Seq_HELA_Human4.17645386
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.25859837
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.02918945
6NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.00004821
7AR_21909140_ChIP-Seq_LNCAP_Human2.80636834
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.56036626
9* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.51266216
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.36509981
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.36509981
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.36509981
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.24669282
14TCF3_18692474_ChIP-Seq_MEFs_Mouse2.20821092
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.13774206
16CLOCK_20551151_ChIP-Seq_293T_Human2.10143516
17* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.08031780
18RXR_22158963_ChIP-Seq_LIVER_Mouse2.07178541
19ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.01972451
20* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.99673778
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.96507146
22TCF3_18692474_ChIP-Seq_MESCs_Mouse1.95214214
23* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.94747799
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.93684529
25PPARA_22158963_ChIP-Seq_LIVER_Mouse1.92443228
26WT1_19549856_ChIP-ChIP_CCG9911_Human1.89186807
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.89008537
28SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.88828996
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.88648724
30HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.79846662
31* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.79675374
32LXR_22158963_ChIP-Seq_LIVER_Mouse1.78526254
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.73129636
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.71684621
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69533593
36ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.69185834
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.68738299
38HIF1A_21447827_ChIP-Seq_MCF-7_Human1.68405794
39* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.68229850
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.66870615
41SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.62562169
42SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.60400032
43ESR1_20079471_ChIP-ChIP_T-47D_Human1.57312516
44* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.56735568
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.54484691
46* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52023949
47NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.50204241
48* ATF3_27146783_Chip-Seq_COLON_Human1.49053414
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.47454550
50NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.47080694
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.44891281
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.44226100
53NANOG_21062744_ChIP-ChIP_HESCs_Human1.42690307
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.42265397
55ISL1_27105846_Chip-Seq_CPCs_Mouse1.41518746
56NFIB_24661679_ChIP-Seq_LUNG_Mouse1.40891320
57FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.38379002
58ZNF263_19887448_ChIP-Seq_K562_Human1.37618342
59POU5F1_16518401_ChIP-PET_MESCs_Mouse1.36594506
60SOX2_18555785_ChIP-Seq_MESCs_Mouse1.35979483
61TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34936790
62PPAR_26484153_Chip-Seq_NCI-H1993_Human1.34710318
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34411119
64SOX9_24532713_ChIP-Seq_HFSC_Mouse1.33781131
65* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.31477426
66CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30598402
67NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.28902364
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.28691745
69* BRD4_25478319_ChIP-Seq_HGPS_Human1.28190424
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.27217185
71RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.27213601
72TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.25939998
73* MYC_18555785_ChIP-Seq_MESCs_Mouse1.25870711
74TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25845974
75* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.23302570
76* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.23302570
77TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21854601
78* RACK7_27058665_Chip-Seq_MCF-7_Human1.21110068
79EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.19228435
80CJUN_26792858_Chip-Seq_BT549_Human1.18658172
81MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18614637
82TP53_18474530_ChIP-ChIP_U2OS_Human1.16950521
83NELFA_20434984_ChIP-Seq_ESCs_Mouse1.15937529
84UBF1/2_26484160_Chip-Seq_HMECs_Human1.15091096
85* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14884070
86TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14868746
87SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.14753784
88* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14706940
89SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13635915
90EP300_21415370_ChIP-Seq_HL-1_Mouse1.13281696
91* GATA6_25053715_ChIP-Seq_YYC3_Human1.12948565
92P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12225752
93ELK3_25401928_ChIP-Seq_HUVEC_Human1.10390393
94TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10172246
95P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09720467
96AHR_22903824_ChIP-Seq_MCF-7_Human1.08592978
97* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08255584
98NANOG_18692474_ChIP-Seq_MESCs_Mouse1.07651732
99EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06838151
100* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.06189320
101SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05740770
102PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.04925978
103NANOG_18692474_ChIP-Seq_MEFs_Mouse1.04858778
104CHD1_26751641_Chip-Seq_LNCaP_Human1.04350416
105KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04332723
106* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03891818
107NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03501496
108ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03234488
109CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02823418
110SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01916790
111SOX2_20726797_ChIP-Seq_SW620_Human1.01276669
112KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00914726
113UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00673009
114TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00046571
115ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99920869
116* CDX2_20551321_ChIP-Seq_CACO-2_Human0.99416686
117TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99216551
118TBX20_22080862_ChIP-Seq_HEART_Mouse0.98204131
119TBX20_22328084_ChIP-Seq_HEART_Mouse0.98204131
120* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97604023
121TCF4_18268006_ChIP-ChIP_LS174T_Human0.97530069
122NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97479672
123FOXA2_19822575_ChIP-Seq_HepG2_Human0.96951491
124* TP53_22127205_ChIP-Seq_IMR90_Human0.96647551
125NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96528204
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96528204
127TP53_20018659_ChIP-ChIP_R1E_Mouse0.95319275
128PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94335606
129SOX17_20123909_ChIP-Seq_XEN_Mouse0.93773973
130RUNX1_27514584_Chip-Seq_MCF-7_Human0.93651456

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.48549899
2MP0008438_abnormal_cutaneous_collagen2.66218859
3MP0010030_abnormal_orbit_morphology2.65278496
4MP0009053_abnormal_anal_canal2.47998244
5MP0003941_abnormal_skin_development2.39759430
6MP0005275_abnormal_skin_tensile2.38646371
7MP0000566_synostosis2.09619619
8MP0000537_abnormal_urethra_morphology1.96697480
9MP0004272_abnormal_basement_membrane1.92354691
10MP0001958_emphysema1.87328654
11MP0003937_abnormal_limbs/digits/tail_de1.85823128
12MP0005503_abnormal_tendon_morphology1.82082383
13MP0010352_gastrointestinal_tract_polyps1.71273754
14MP0002249_abnormal_larynx_morphology1.70271571
15MP0005171_absent_coat_pigmentation1.58789716
16MP0000751_myopathy1.58376169
17MP0002877_abnormal_melanocyte_morpholog1.56577924
18MP0010234_abnormal_vibrissa_follicle1.55477757
19MP0003566_abnormal_cell_adhesion1.54956307
20MP0001299_abnormal_eye_distance/1.48539788
21MP0009250_abnormal_appendicular_skeleto1.45931559
22MP0003123_paternal_imprinting1.45413150
23MP0009780_abnormal_chondrocyte_physiolo1.45305285
24MP0005248_abnormal_Harderian_gland1.45263132
25MP0002060_abnormal_skin_morphology1.44826176
26MP0005451_abnormal_body_composition1.44684362
27MP0004185_abnormal_adipocyte_glucose1.43397143
28MP0005409_darkened_coat_color1.41560606
29MP0010368_abnormal_lymphatic_system1.41520593
30MP0009384_cardiac_valve_regurgitation1.40141328
31MP0005623_abnormal_meninges_morphology1.38636549
32MP0000579_abnormal_nail_morphology1.37774350
33MP0003111_abnormal_nucleus_morphology1.36000305
34MP0003755_abnormal_palate_morphology1.33209576
35MP0001849_ear_inflammation1.32854542
36* MP0003385_abnormal_body_wall1.32096378
37MP0000762_abnormal_tongue_morphology1.31802723
38MP0000733_abnormal_muscle_development1.30238038
39MP0003942_abnormal_urinary_system1.29674554
40MP0003136_yellow_coat_color1.29497143
41MP0003567_abnormal_fetal_cardiomyocyte1.29329187
42MP0003115_abnormal_respiratory_system1.29097876
43MP0005508_abnormal_skeleton_morphology1.28796267
44* MP0002085_abnormal_embryonic_tissue1.28369425
45MP0004957_abnormal_blastocyst_morpholog1.27554618
46MP0003935_abnormal_craniofacial_develop1.27119978
47MP0004858_abnormal_nervous_system1.26481661
48* MP0002084_abnormal_developmental_patter1.26022693
49* MP0005380_embryogenesis_phenotype1.25831128
50* MP0001672_abnormal_embryogenesis/_devel1.25831128
51MP0003091_abnormal_cell_migration1.25455157
52MP0002796_impaired_skin_barrier1.24433363
53MP0003119_abnormal_digestive_system1.23597750
54MP0003077_abnormal_cell_cycle1.23331724
55MP0005076_abnormal_cell_differentiation1.23050338
56MP0004233_abnormal_muscle_weight1.22436066
57MP0002932_abnormal_joint_morphology1.20789560
58MP0005023_abnormal_wound_healing1.20212688
59MP0004197_abnormal_fetal_growth/weight/1.19953121
60MP0002108_abnormal_muscle_morphology1.19357682
61MP0000428_abnormal_craniofacial_morphol1.19227048
62MP0003984_embryonic_growth_retardation1.18969735
63MP0002088_abnormal_embryonic_growth/wei1.18671713
64MP0002896_abnormal_bone_mineralization1.18357232
65MP0000432_abnormal_head_morphology1.17765701
66MP0002653_abnormal_ependyma_morphology1.16375182
67MP0001730_embryonic_growth_arrest1.15569971
68MP0002139_abnormal_hepatobiliary_system1.15331410
69MP0002282_abnormal_trachea_morphology1.14752419
70MP0004264_abnormal_extraembryonic_tissu1.13822875
71MP0000749_muscle_degeneration1.13405103
72MP0003693_abnormal_embryo_hatching1.13038518
73MP0005360_urolithiasis1.12569926
74MP0000462_abnormal_digestive_system1.12457624
75MP0002233_abnormal_nose_morphology1.11469863
76MP0004084_abnormal_cardiac_muscle1.10497168
77MP0003718_maternal_effect1.10322445
78MP0005257_abnormal_intraocular_pressure1.09292110
79MP0003279_aneurysm1.08869111
80MP0002111_abnormal_tail_morphology1.08719149
81MP0000516_abnormal_urinary_system1.07921402
82MP0005367_renal/urinary_system_phenotyp1.07921402
83* MP0002086_abnormal_extraembryonic_tissu1.06902941
84MP0000534_abnormal_ureter_morphology1.06789531
85MP0002697_abnormal_eye_size1.05726386
86MP0005187_abnormal_penis_morphology1.05140277
87MP0000350_abnormal_cell_proliferation1.04353895
88MP0000767_abnormal_smooth_muscle1.03253238
89MP0008007_abnormal_cellular_replicative1.03026096
90* MP0001697_abnormal_embryo_size1.01301848
91MP0006138_congestive_heart_failure0.98971745
92MP0005085_abnormal_gallbladder_physiolo0.98711324
93MP0005330_cardiomyopathy0.98440895
94MP0002098_abnormal_vibrissa_morphology0.98433070
95MP0005666_abnormal_adipose_tissue0.98331621
96MP0000750_abnormal_muscle_regeneration0.97910116
97MP0006054_spinal_hemorrhage0.97397102
98MP0010094_abnormal_chromosome_stability0.97154440
99MP0005365_abnormal_bile_salt0.97131344
100MP0010678_abnormal_skin_adnexa0.96922851
101MP0003453_abnormal_keratinocyte_physiol0.95579916
102MP0003252_abnormal_bile_duct0.94527757
103MP0001293_anophthalmia0.94480783
104MP0001346_abnormal_lacrimal_gland0.94068190
105MP0000383_abnormal_hair_follicle0.93962874
106MP0003315_abnormal_perineum_morphology0.92826781
107MP0001661_extended_life_span0.92508624
108MP0001915_intracranial_hemorrhage0.92289740
109MP0005408_hypopigmentation0.91774616
110MP0004087_abnormal_muscle_fiber0.91478142
111MP0005501_abnormal_skin_physiology0.91064396
112MP0005197_abnormal_uvea_morphology0.90993203
113MP0010630_abnormal_cardiac_muscle0.90853602
114MP0000003_abnormal_adipose_tissue0.90060476
115MP0000049_abnormal_middle_ear0.89104622
116MP0000377_abnormal_hair_follicle0.88487642
117MP0000467_abnormal_esophagus_morphology0.88322318
118MP0001286_abnormal_eye_development0.88098725
119MP0002116_abnormal_craniofacial_bone0.88085472
120MP0002092_abnormal_eye_morphology0.87707544
121MP0002089_abnormal_postnatal_growth/wei0.87591638
122MP0003950_abnormal_plasma_membrane0.87527360
123MP0002925_abnormal_cardiovascular_devel0.87503273
124MP0001216_abnormal_epidermal_layer0.85232228
125MP0004782_abnormal_surfactant_physiolog0.84705200
126MP0000013_abnormal_adipose_tissue0.84296266
127MP0009672_abnormal_birth_weight0.83488109
128MP0001879_abnormal_lymphatic_vessel0.82081787
129MP0002938_white_spotting0.81446230
130MP0000759_abnormal_skeletal_muscle0.80342501
131MP0002269_muscular_atrophy0.78480716
132MP0010771_integument_phenotype0.78286496
133MP0005377_hearing/vestibular/ear_phenot0.77611084
134MP0003878_abnormal_ear_physiology0.77611084

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.99334128
2Premature rupture of membranes (HP:0001788)3.49432987
3Shallow orbits (HP:0000586)3.32048107
4Arterial tortuosity (HP:0005116)3.24958031
5Vascular tortuosity (HP:0004948)3.24795380
6Ankle contracture (HP:0006466)3.02248610
7Right ventricular cardiomyopathy (HP:0011663)3.00670087
8Shawl scrotum (HP:0000049)2.70260905
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.70154447
10Short 4th metacarpal (HP:0010044)2.70154447
11Abnormality of the 4th metacarpal (HP:0010012)2.66332585
12Increased connective tissue (HP:0009025)2.65889764
13Atrophic scars (HP:0001075)2.64528973
14Vertebral arch anomaly (HP:0008438)2.39498289
15Selective tooth agenesis (HP:0001592)2.34834252
16Pterygium (HP:0001059)2.32324856
17Osteolytic defects of the phalanges of the hand (HP:0009771)2.30004296
18Osteolytic defects of the hand bones (HP:0009699)2.30004296
19Aortic dissection (HP:0002647)2.28323956
20Wormian bones (HP:0002645)2.24832918
21Mildly elevated creatine phosphokinase (HP:0008180)2.19488538
22Broad metatarsal (HP:0001783)2.18925437
23Aplasia involving bones of the upper limbs (HP:0009823)2.11810546
24Aplasia of the phalanges of the hand (HP:0009802)2.11810546
25Aplasia involving bones of the extremities (HP:0009825)2.11810546
26Wrist flexion contracture (HP:0001239)2.11786688
27Coronal craniosynostosis (HP:0004440)2.08013749
28Rectal prolapse (HP:0002035)2.06619871
29Alopecia of scalp (HP:0002293)2.03614322
30Peritonitis (HP:0002586)2.01592576
31Cerebral aneurysm (HP:0004944)2.00628774
32Asymmetry of the thorax (HP:0001555)2.00500861
33Ulnar bowing (HP:0003031)1.98958483
34Type 1 muscle fiber predominance (HP:0003803)1.98521500
35Short nail (HP:0001799)1.98313871
36Camptodactyly of toe (HP:0001836)1.98306449
37Soft skin (HP:0000977)1.96812560
38Abnormality of the acetabulum (HP:0003170)1.96523739
39Deep venous thrombosis (HP:0002625)1.94708944
40Male infertility (HP:0003251)1.94041128
41Flat acetabular roof (HP:0003180)1.93946813
42Vertebral compression fractures (HP:0002953)1.91957306
43Aortic aneurysm (HP:0004942)1.91417367
44Abnormal ossification of hand bones (HP:0005921)1.90721823
45Hypoplastic ischia (HP:0003175)1.90012898
46Bladder diverticulum (HP:0000015)1.89785143
47Abnormality of the distal phalanx of the thumb (HP:0009617)1.89732159
48Ventricular tachycardia (HP:0004756)1.88092562
49Broad thumb (HP:0011304)1.87608477
50Scapular winging (HP:0003691)1.87484542
51Genu recurvatum (HP:0002816)1.86902291
52Hyperacusis (HP:0010780)1.86016586
53Ankyloglossia (HP:0010296)1.85835053
54Mitral valve prolapse (HP:0001634)1.84628129
55Aneurysm (HP:0002617)1.84340031
56Hip contracture (HP:0003273)1.84282450
57Elbow flexion contracture (HP:0002987)1.84279177
58Mitral regurgitation (HP:0001653)1.83738877
59Follicular hyperkeratosis (HP:0007502)1.83175669
60Abnormality of carpal bone ossification (HP:0006257)1.82481830
61Arnold-Chiari malformation (HP:0002308)1.81692323
62Increased variability in muscle fiber diameter (HP:0003557)1.81035509
63Preaxial foot polydactyly (HP:0001841)1.79667406
64Bronchomalacia (HP:0002780)1.79415565
65Hypoplastic labia majora (HP:0000059)1.79027584
66Syringomyelia (HP:0003396)1.78776738
67Spinal cord lesions (HP:0100561)1.78776738
68Renal duplication (HP:0000075)1.78171575
69Short 5th finger (HP:0009237)1.77494941
70Milia (HP:0001056)1.77350757
71Broad toe (HP:0001837)1.76786151
72Overgrowth (HP:0001548)1.76716700
73Abnormal delivery (HP:0001787)1.76096365
74Partial duplication of the phalanx of hand (HP:0009999)1.75787504
75Synostosis of carpal bones (HP:0005048)1.75764367
76Neonatal short-limb short stature (HP:0008921)1.75557641
77Knee flexion contracture (HP:0006380)1.75327604
78Blue sclerae (HP:0000592)1.75289056
79Natal tooth (HP:0000695)1.74801218
80Abnormality of the calcaneus (HP:0008364)1.74676388
81Hyperextensible skin (HP:0000974)1.74631615
82Absent eyelashes (HP:0000561)1.74409172
83Fragile skin (HP:0001030)1.74310716
84Muscle fiber splitting (HP:0003555)1.73151287
85Partial duplication of thumb phalanx (HP:0009944)1.73095714
86Dilatation of the ascending aorta (HP:0005111)1.72653050
87Joint laxity (HP:0001388)1.72502098
88Wide anterior fontanel (HP:0000260)1.71348774
89Tarsal synostosis (HP:0008368)1.70770628
90Breast hypoplasia (HP:0003187)1.70029990
91Lip pit (HP:0100267)1.69368311
92Midline defect of the nose (HP:0004122)1.69293971
93Rib fusion (HP:0000902)1.69043247
94Mesomelia (HP:0003027)1.67987385
95Bowing of the arm (HP:0006488)1.67947702
96Bowed forearm bones (HP:0003956)1.67947702
97Abnormality of the ischium (HP:0003174)1.67759567
98Deviation of the hallux (HP:0010051)1.66985490
99Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.66567277
100Papillary thyroid carcinoma (HP:0002895)1.65890060
101Abnormality of the labia majora (HP:0012881)1.65456991
102Lymphangioma (HP:0100764)1.64511369
103Turricephaly (HP:0000262)1.64028381
104Disproportionate tall stature (HP:0001519)1.63799021
105Spinal rigidity (HP:0003306)1.63559797
106Carpal synostosis (HP:0009702)1.63420867
107Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.63051860
108Midface retrusion (HP:0011800)1.62239195
109Short humerus (HP:0005792)1.61422296
110Fragile nails (HP:0001808)1.60817981
111Abnormality of skeletal muscle fiber size (HP:0012084)1.60508978
112Abnormality of oral frenula (HP:0000190)1.60250911
113Synostosis involving bones of the lower limbs (HP:0009138)1.59061794
114Synostosis involving bones of the feet (HP:0009140)1.59061794
115Short hallux (HP:0010109)1.58487496
116Abnormality of the labia minora (HP:0012880)1.58177154
117Limited hip movement (HP:0008800)1.57441411
118Broad hallux (HP:0010055)1.57233085
119Abnormality of dentin (HP:0010299)1.56929905
120Broad face (HP:0000283)1.56888006
121Abnormality of the parietal bone (HP:0002696)1.56868194
122Round ear (HP:0100830)1.56705595
123Patellar aplasia (HP:0006443)1.56460430
124Biconcave vertebral bodies (HP:0004586)1.55899711
125Morphological abnormality of the middle ear (HP:0008609)1.55683700
126Broad long bones (HP:0005622)1.55576237
127Neonatal death (HP:0003811)1.54930719
128Cervical subluxation (HP:0003308)1.54884795
129Abnormality of the lacrimal duct (HP:0011481)1.54686139
130Cardiovascular calcification (HP:0011915)1.54096893
131Abnormal hand bone ossification (HP:0010660)1.53875846
132Facial hemangioma (HP:0000329)1.53706486
133Short 1st metacarpal (HP:0010034)1.53614055
134Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.53614055
135Aplasia/Hypoplasia of the patella (HP:0006498)1.53367651
136Bowel diverticulosis (HP:0005222)1.52701430
137Achilles tendon contracture (HP:0001771)1.52603345
138Breech presentation (HP:0001623)1.52218025
139Aplasia/hypoplasia of the humerus (HP:0006507)1.51816441
140Thin ribs (HP:0000883)1.51213054
141Advanced eruption of teeth (HP:0006288)1.51037557
142Hallux valgus (HP:0001822)1.50795850
143Ectopic kidney (HP:0000086)1.50221665
144Distal lower limb amyotrophy (HP:0008944)1.50154383
145Abnormality of the phalanges of the hallux (HP:0010057)1.49869032
146Cupped ribs (HP:0000887)1.49508719
147Choanal stenosis (HP:0000452)1.48308774
148Broad phalanges of the hand (HP:0009768)1.48173056
149Abnormality of the nasolacrimal system (HP:0000614)1.47669419
150Intrahepatic cholestasis (HP:0001406)1.47597745
151Subacute progressive viral hepatitis (HP:0006572)1.45780401
152Short phalanx of the thumb (HP:0009660)1.45360267
153Oligodactyly (HP:0012165)1.45167173
154Hyporeflexia of lower limbs (HP:0002600)1.45151544
155Broad phalanx (HP:0006009)1.44928165
156Pseudobulbar signs (HP:0002200)1.44741157
157Hepatoblastoma (HP:0002884)1.44376040
158Back pain (HP:0003418)1.43544076

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.10614767
2EPHA22.94694388
3TTN2.60440300
4TRIB32.56325007
5DDR22.51254053
6TTK2.47570522
7PKN22.39451776
8PDGFRA2.34177511
9MYLK2.30057063
10ERBB42.23582052
11CDC72.20905141
12EPHB22.04163570
13NTRK12.01401840
14SIK11.89017213
15NEK21.70458965
16* STK31.66790620
17PLK41.57511571
18EEF2K1.54573091
19RPS6KB21.54296444
20DMPK1.51342888
21MET1.49800175
22NEK11.46870926
23CDK71.43326272
24MTOR1.40262809
25RIPK11.38959580
26MAP3K61.37856819
27PAK41.37426964
28SMG11.32718168
29CHEK21.29087792
30FGFR41.28508693
31PAK21.23160165
32FER1.22610017
33PBK1.22292090
34PTK21.21423611
35BMX1.18772337
36PTK61.16281633
37CAMK1D1.14710414
38CDK61.14190366
39CDK81.14033598
40PLK11.11693638
41PDGFRB1.11032276
42* LATS11.09070893
43AURKB1.08741842
44TGFBR21.08626006
45MAP3K81.07134151
46MELK1.07077793
47FGFR11.06636563
48CDK41.06533024
49MAP3K31.02836696
50NEK91.01703475
51PRKD30.99956413
52ABL20.98616893
53NUAK10.98458814
54TAOK10.96686810
55TGFBR10.94866050
56STK100.91728133
57ICK0.90641706
58AKT30.87446825
59OBSCN0.87445682
60TESK10.87404701
61WEE10.87014357
62MAPKAPK30.86696372
63CHEK10.85782373
64MAP3K100.85226692
65ZAK0.84629340
66MST1R0.83739528
67TYRO30.83671462
68RPS6KA40.82870646
69STK390.80237105
70ERN10.80003155
71SRPK10.79851549
72FRK0.79674672
73BCKDK0.78950056
74CDK90.78862026
75SCYL20.77831279
76ATM0.77439757
77LMTK20.75020416
78MAP3K20.73355045
79CDC42BPA0.73018254
80MAP3K90.72613838
81PIK3CA0.72439312
82EPHB10.72332765
83STK40.71755931
84LIMK10.71340587
85TIE10.70304519
86PLK30.68795589
87BRD40.68352839
88AKT20.68009865
89FGFR20.64459606
90KSR20.64349476
91PRKAA20.64347497
92MOS0.63798246
93ROCK20.63568841
94STK240.61944474
95PRKD20.61805133
96BRSK20.61721678
97TSSK60.60859426
98TRPM70.60676478
99ROCK10.59925047
100PAK30.59336209
101PRKAA10.59059621
102TAF10.59020262
103ERBB20.58485252
104PNCK0.57922860
105BUB10.57002840
106ATR0.56287746
107PRKCI0.55569613
108BCR0.55422363
109PDK40.54863701
110PDK30.54863701
111DYRK30.54360099
112NLK0.54257245
113MAP3K70.53997208
114MAPK110.53909411
115CDK20.53802390
116EPHA30.53635613
117NME10.52761617
118RET0.51881196
119FLT30.50699947
120PDK20.48456635
121MAP2K10.48296901
122ILK0.47810664
123MAP2K20.47285690
124MKNK10.47107200
125* LATS20.47028942
126CSNK1E0.46640149
127RPS6KA20.46394731
128PRKG20.46031045
129GSK3A0.45487475
130IRAK30.44823706
131CAMK1G0.43621895
132AURKA0.43068558
133WNK10.39443924
134FGFR30.39052941
135WNK40.38649957
136BRSK10.33070774
137KSR10.32304644

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052172.28046416
2Adherens junction_Homo sapiens_hsa045202.09218066
3* Hippo signaling pathway_Homo sapiens_hsa043901.99920140
4ECM-receptor interaction_Homo sapiens_hsa045121.98143680
5TGF-beta signaling pathway_Homo sapiens_hsa043501.92282398
6Lysine degradation_Homo sapiens_hsa003101.90554506
7Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.86292225
8Cell cycle_Homo sapiens_hsa041101.79674388
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.77626478
10Fatty acid degradation_Homo sapiens_hsa000711.71875760
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.67503169
12Hedgehog signaling pathway_Homo sapiens_hsa043401.65149271
13One carbon pool by folate_Homo sapiens_hsa006701.60408017
14MicroRNAs in cancer_Homo sapiens_hsa052061.60266557
15p53 signaling pathway_Homo sapiens_hsa041151.56204924
16Arginine biosynthesis_Homo sapiens_hsa002201.56108613
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.56024272
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.55804141
19Small cell lung cancer_Homo sapiens_hsa052221.54362107
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.51438661
21RNA transport_Homo sapiens_hsa030131.48070600
22Nitrogen metabolism_Homo sapiens_hsa009101.45485638
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.45395064
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.45036147
25Bladder cancer_Homo sapiens_hsa052191.40780384
26Focal adhesion_Homo sapiens_hsa045101.38113612
27Biosynthesis of amino acids_Homo sapiens_hsa012301.37779395
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.37502576
29Tryptophan metabolism_Homo sapiens_hsa003801.36032717
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35568724
31Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.29547690
32Tight junction_Homo sapiens_hsa045301.29456724
33Selenocompound metabolism_Homo sapiens_hsa004501.28195681
34Regulation of actin cytoskeleton_Homo sapiens_hsa048101.26863727
35PPAR signaling pathway_Homo sapiens_hsa033201.26281955
36Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.25389896
37Melanogenesis_Homo sapiens_hsa049161.25196707
38Fatty acid metabolism_Homo sapiens_hsa012121.24919013
39Propanoate metabolism_Homo sapiens_hsa006401.24406034
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21508587
41Proteoglycans in cancer_Homo sapiens_hsa052051.20050998
42Complement and coagulation cascades_Homo sapiens_hsa046101.14373341
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.14306459
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12494906
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11494093
46Axon guidance_Homo sapiens_hsa043601.09642557
47Notch signaling pathway_Homo sapiens_hsa043301.07785545
48Carbon metabolism_Homo sapiens_hsa012001.05986902
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.04561775
50Retinol metabolism_Homo sapiens_hsa008301.04303626
51RNA degradation_Homo sapiens_hsa030181.03289304
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03236578
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.02258514
54Chemical carcinogenesis_Homo sapiens_hsa052041.00675388
55Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.96358556
56beta-Alanine metabolism_Homo sapiens_hsa004100.96189672
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96151061
58Protein digestion and absorption_Homo sapiens_hsa049740.94994549
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94462932
60Vitamin B6 metabolism_Homo sapiens_hsa007500.94251256
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93776189
62Thyroid cancer_Homo sapiens_hsa052160.93728097
63N-Glycan biosynthesis_Homo sapiens_hsa005100.93626584
64mRNA surveillance pathway_Homo sapiens_hsa030150.93556621
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92517105
66Renal cell carcinoma_Homo sapiens_hsa052110.91324872
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.90455525
68Arginine and proline metabolism_Homo sapiens_hsa003300.88625729
69Fatty acid biosynthesis_Homo sapiens_hsa000610.88177986
70Wnt signaling pathway_Homo sapiens_hsa043100.86803047
71Melanoma_Homo sapiens_hsa052180.86237691
72Prion diseases_Homo sapiens_hsa050200.86108468
73Sphingolipid metabolism_Homo sapiens_hsa006000.85871678
74Colorectal cancer_Homo sapiens_hsa052100.85394720
75Fanconi anemia pathway_Homo sapiens_hsa034600.83845429
76Phenylalanine metabolism_Homo sapiens_hsa003600.83237141
77Prostate cancer_Homo sapiens_hsa052150.81993138
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80116243
79Tyrosine metabolism_Homo sapiens_hsa003500.80049498
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79541718
81Gap junction_Homo sapiens_hsa045400.79366443
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.78650503
83Dilated cardiomyopathy_Homo sapiens_hsa054140.78065781
84Insulin signaling pathway_Homo sapiens_hsa049100.77586444
85Pathways in cancer_Homo sapiens_hsa052000.77329315
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76128717
87Amoebiasis_Homo sapiens_hsa051460.75056218
88mTOR signaling pathway_Homo sapiens_hsa041500.74573628
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73778995
90Endometrial cancer_Homo sapiens_hsa052130.73161843
91Caffeine metabolism_Homo sapiens_hsa002320.71666025
92Basal transcription factors_Homo sapiens_hsa030220.71580914
93Viral myocarditis_Homo sapiens_hsa054160.71284071
94Fat digestion and absorption_Homo sapiens_hsa049750.71220557
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.71194982
96Ovarian steroidogenesis_Homo sapiens_hsa049130.71026106
97Histidine metabolism_Homo sapiens_hsa003400.69470685
98Pyruvate metabolism_Homo sapiens_hsa006200.68979594
99Glioma_Homo sapiens_hsa052140.68709553
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68133807
101Starch and sucrose metabolism_Homo sapiens_hsa005000.68048149
102Thyroid hormone synthesis_Homo sapiens_hsa049180.67941495
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.66867273
104Glutathione metabolism_Homo sapiens_hsa004800.65672997
105Butanoate metabolism_Homo sapiens_hsa006500.65531481
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.65337465
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65248955
108AMPK signaling pathway_Homo sapiens_hsa041520.65119718
109Mismatch repair_Homo sapiens_hsa034300.64366272
110Pentose phosphate pathway_Homo sapiens_hsa000300.64306916
111Pancreatic cancer_Homo sapiens_hsa052120.62993983
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62671242
113Homologous recombination_Homo sapiens_hsa034400.62089142
114Insulin resistance_Homo sapiens_hsa049310.61662799
115ErbB signaling pathway_Homo sapiens_hsa040120.61066291
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60700764
117Chronic myeloid leukemia_Homo sapiens_hsa052200.60638993
118Peroxisome_Homo sapiens_hsa041460.60460907
119HTLV-I infection_Homo sapiens_hsa051660.60460854
120Galactose metabolism_Homo sapiens_hsa000520.60398343
121Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60169445
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60152882
123Dorso-ventral axis formation_Homo sapiens_hsa043200.59171341
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.58547926
125Spliceosome_Homo sapiens_hsa030400.57563487
126Nucleotide excision repair_Homo sapiens_hsa034200.56429706
127Bile secretion_Homo sapiens_hsa049760.55677885
128Vitamin digestion and absorption_Homo sapiens_hsa049770.55492290
129Rap1 signaling pathway_Homo sapiens_hsa040150.55181893
130Glucagon signaling pathway_Homo sapiens_hsa049220.54650157
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54353232
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54338753
133Circadian rhythm_Homo sapiens_hsa047100.52714355
134Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50821806
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49446814
136Estrogen signaling pathway_Homo sapiens_hsa049150.49391023
137Vascular smooth muscle contraction_Homo sapiens_hsa042700.45653259
138VEGF signaling pathway_Homo sapiens_hsa043700.45350022
139Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42828073
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.42346982
141Choline metabolism in cancer_Homo sapiens_hsa052310.40033408
142Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39347856
143Renin-angiotensin system_Homo sapiens_hsa046140.37579579
144Non-small cell lung cancer_Homo sapiens_hsa052230.36941236

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