YBEY

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a highly conserved metalloprotein. A similar protein in bacteria acts as an endoribonuclease, and is thought to function in ribosomal RNA maturation and ribosome assembly. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)5.05133097
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.02047865
3ribosomal small subunit biogenesis (GO:0042274)4.97375403
4maturation of SSU-rRNA (GO:0030490)4.96541159
5regulation of mitochondrial translation (GO:0070129)4.45899256
6energy coupled proton transport, down electrochemical gradient (GO:0015985)4.44031402
7ATP synthesis coupled proton transport (GO:0015986)4.44031402
8base-excision repair, AP site formation (GO:0006285)4.43541083
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.42418302
10ribosomal small subunit assembly (GO:0000028)4.41593503
11keratinocyte development (GO:0003334)4.39222337
12establishment of protein localization to mitochondrial membrane (GO:0090151)4.36523958
13mitochondrial respiratory chain complex I assembly (GO:0032981)4.32006517
14NADH dehydrogenase complex assembly (GO:0010257)4.32006517
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.32006517
16protein complex biogenesis (GO:0070271)4.27043359
17peptidyl-histidine modification (GO:0018202)4.23732232
18limb bud formation (GO:0060174)4.10072581
19viral transcription (GO:0019083)4.08859912
20respiratory electron transport chain (GO:0022904)4.08432671
21mitochondrial respiratory chain complex assembly (GO:0033108)4.08213942
22protein neddylation (GO:0045116)4.02453128
23termination of RNA polymerase III transcription (GO:0006386)4.00871525
24transcription elongation from RNA polymerase III promoter (GO:0006385)4.00871525
25electron transport chain (GO:0022900)4.00004535
26respiratory chain complex IV assembly (GO:0008535)3.99750222
27superoxide anion generation (GO:0042554)3.98509772
28protein deneddylation (GO:0000338)3.97818791
29central nervous system myelination (GO:0022010)3.95233981
30axon ensheathment in central nervous system (GO:0032291)3.95233981
31presynaptic membrane assembly (GO:0097105)3.95212301
32histone H2B ubiquitination (GO:0033523)3.94830598
33translational termination (GO:0006415)3.93518776
34cullin deneddylation (GO:0010388)3.92196208
35protein targeting to mitochondrion (GO:0006626)3.81791153
36SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.80562202
37pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.77955358
38presynaptic membrane organization (GO:0097090)3.75169930
39cotranslational protein targeting to membrane (GO:0006613)3.72897380
40protein targeting to ER (GO:0045047)3.68644136
41nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.64368699
42protein localization to endoplasmic reticulum (GO:0070972)3.58436986
43regulation of timing of cell differentiation (GO:0048505)3.58124682
44establishment of protein localization to endoplasmic reticulum (GO:0072599)3.57973255
45deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.57824968
46exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.56975947
47translational elongation (GO:0006414)3.56400812
48establishment of protein localization to mitochondrion (GO:0072655)3.54480786
49rRNA modification (GO:0000154)3.50117651
50protein localization to mitochondrion (GO:0070585)3.48920769
51translation (GO:0006412)3.46786631
52cellular component biogenesis (GO:0044085)3.46038725
53cytochrome complex assembly (GO:0017004)3.43305149
54RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.42930290
55tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.42930290
56righting reflex (GO:0060013)3.39995086
57iron-sulfur cluster assembly (GO:0016226)3.39895236
58metallo-sulfur cluster assembly (GO:0031163)3.39895236
59ubiquinone biosynthetic process (GO:0006744)3.39385841
60negative regulation of execution phase of apoptosis (GO:1900118)3.38511462
61long-chain fatty acid biosynthetic process (GO:0042759)3.37742786
62proteasome assembly (GO:0043248)3.35596046
63axonemal dynein complex assembly (GO:0070286)3.30313748
64chromatin remodeling at centromere (GO:0031055)3.29240458
65viral life cycle (GO:0019058)3.28559760
66adenosine metabolic process (GO:0046085)3.26534080
67negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.24636450
68ribonucleoprotein complex biogenesis (GO:0022613)3.23910952
69G-protein coupled receptor internalization (GO:0002031)3.22823573
70cell proliferation in forebrain (GO:0021846)3.20718724
71pyrimidine nucleotide catabolic process (GO:0006244)3.20526082
72establishment of integrated proviral latency (GO:0075713)3.19576211
73ribosomal large subunit biogenesis (GO:0042273)3.18563158
74retina layer formation (GO:0010842)3.18223547
75translational initiation (GO:0006413)3.18206958
76GDP-mannose metabolic process (GO:0019673)3.17273338
77regulation of development, heterochronic (GO:0040034)3.17072037
78lymphoid progenitor cell differentiation (GO:0002320)3.16700137
79nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.16441094
80protein heterotetramerization (GO:0051290)3.14429926
81postsynaptic membrane organization (GO:0001941)3.14342542
82pseudouridine synthesis (GO:0001522)3.13187497
83regulation of pigment cell differentiation (GO:0050932)3.12385068
84oxidative phosphorylation (GO:0006119)3.12101561
85establishment of viral latency (GO:0019043)3.11504463
86ubiquinone metabolic process (GO:0006743)3.10179387
87pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.09656488
88ncRNA 3-end processing (GO:0043628)3.06046051
89DNA ligation (GO:0006266)3.05787192
90* rRNA processing (GO:0006364)3.03983469
91cellular protein complex disassembly (GO:0043624)3.03978522
92regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.02927341
93positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.02781429
94CENP-A containing nucleosome assembly (GO:0034080)3.01800485
95positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.00866609
96DNA damage response, detection of DNA damage (GO:0042769)3.00395491
97negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.98559150
98negative regulation of ligase activity (GO:0051352)2.98559150
99mesenchymal cell differentiation involved in renal system development (GO:2001012)2.98527272
100mesenchymal cell differentiation involved in kidney development (GO:0072161)2.98527272
101amino sugar catabolic process (GO:0046348)2.97709398
102* rRNA metabolic process (GO:0016072)2.97084828
103deoxyribonucleotide catabolic process (GO:0009264)2.96828023
104female gonad development (GO:0008585)2.95569894
105positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.94842915
106positive regulation of protein kinase C signaling (GO:0090037)2.94246976
107water-soluble vitamin biosynthetic process (GO:0042364)2.94164883
108cranial nerve morphogenesis (GO:0021602)2.92298964
109reflex (GO:0060004)2.90151434
110detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.89813564
111intracellular protein transmembrane import (GO:0044743)2.88280589
112short-term memory (GO:0007614)2.87768281
113response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.85803091
114startle response (GO:0001964)2.85607094
115glucosamine-containing compound catabolic process (GO:1901072)2.85260273
116DNA integration (GO:0015074)2.85259210
117neuron cell-cell adhesion (GO:0007158)2.84280505
118GTP biosynthetic process (GO:0006183)2.84130373
119spliceosomal snRNP assembly (GO:0000387)2.84051348
120polyol transport (GO:0015791)2.83873839
121anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.82858690
122DNA deamination (GO:0045006)2.82039730
123tRNA processing (GO:0008033)2.80087095
124regulation of cellular amino acid metabolic process (GO:0006521)2.80055983
125microtubule depolymerization (GO:0007019)2.77973230
126negative regulation of keratinocyte proliferation (GO:0010839)2.77908819
127formation of translation preinitiation complex (GO:0001731)2.77892071
128mitochondrial transport (GO:0006839)2.77797730
129transcription from RNA polymerase III promoter (GO:0006383)2.77253850
130pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.76047019
131deoxyribose phosphate catabolic process (GO:0046386)2.75738570
132sympathetic nervous system development (GO:0048485)2.75595653
133cerebral cortex radially oriented cell migration (GO:0021799)2.75301711
134preassembly of GPI anchor in ER membrane (GO:0016254)2.74874655
135negative regulation of myoblast differentiation (GO:0045662)2.74867202
136regulation of activation of Janus kinase activity (GO:0010533)2.74093047
137transcription from mitochondrial promoter (GO:0006390)2.73497665
138ribosome biogenesis (GO:0042254)2.72798681
139CTP biosynthetic process (GO:0006241)2.72204849
140CTP metabolic process (GO:0046036)2.72204849
141GPI anchor biosynthetic process (GO:0006506)2.72148661
142adult feeding behavior (GO:0008343)2.71128903
143quinone biosynthetic process (GO:1901663)2.69881076
144response to X-ray (GO:0010165)2.69868705
145developmental pigmentation (GO:0048066)2.69192062
146L-serine metabolic process (GO:0006563)2.69101967
147mesonephros development (GO:0001823)2.68282846
148nuclear-transcribed mRNA catabolic process (GO:0000956)2.67899155
149pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.67185287
150DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.66658660
151purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.66451528
152rRNA methylation (GO:0031167)2.65382037
153otic vesicle formation (GO:0030916)2.63935758
154positive regulation of synapse assembly (GO:0051965)2.61743380
155centriole assembly (GO:0098534)2.60889750
156left/right axis specification (GO:0070986)2.60854202
157GPI anchor metabolic process (GO:0006505)2.60154807
158inner ear receptor stereocilium organization (GO:0060122)2.60139684
159regulation of somitogenesis (GO:0014807)2.59795033
160positive regulation of action potential (GO:0045760)2.53714161
161DNA strand renaturation (GO:0000733)2.51401810
162sphingoid metabolic process (GO:0046519)2.50197441
163cilium or flagellum-dependent cell motility (GO:0001539)2.49595232
164photoreceptor cell maintenance (GO:0045494)2.49390799
165cilium movement (GO:0003341)2.46821192
166negative regulation of homotypic cell-cell adhesion (GO:0034111)2.46483851
167negative regulation of synaptic transmission, GABAergic (GO:0032229)2.46060112
168ceramide catabolic process (GO:0046514)2.44422385
169positive regulation of cellular amine metabolic process (GO:0033240)2.43599653
170spinal cord association neuron differentiation (GO:0021527)2.43396642
171cell fate commitment involved in formation of primary germ layer (GO:0060795)2.42851747
172positive regulation of protein homodimerization activity (GO:0090073)2.42305264
173opioid receptor signaling pathway (GO:0038003)2.41470579
174regulation of platelet aggregation (GO:0090330)2.41082099
175regulation of inositol phosphate biosynthetic process (GO:0010919)2.40519121
176androgen biosynthetic process (GO:0006702)2.40232704
177cranial nerve structural organization (GO:0021604)2.37218715
178cell morphogenesis involved in neuron differentiation (GO:0048667)2.34637965
179cranial nerve development (GO:0021545)2.29456459
180nonmotile primary cilium assembly (GO:0035058)2.28268044
181positive regulation of NIK/NF-kappaB signaling (GO:1901224)2.25320658
182motile cilium assembly (GO:0044458)2.24185656
183negative regulation of transcription by competitive promoter binding (GO:0010944)2.23557053
184regulation of memory T cell differentiation (GO:0043380)2.22075836
185facial nerve structural organization (GO:0021612)2.21913913
186RNA destabilization (GO:0050779)2.21644747
187G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.20574181
188response to folic acid (GO:0051593)2.19734769
189negative regulation of osteoblast proliferation (GO:0033689)2.19289757
190extracellular regulation of signal transduction (GO:1900115)2.19029423
191extracellular negative regulation of signal transduction (GO:1900116)2.19029423
192negative regulation of DNA-dependent DNA replication (GO:2000104)2.18654446
193cornea development in camera-type eye (GO:0061303)2.18223049
194regulation of NIK/NF-kappaB signaling (GO:1901222)2.17081875
195regulation of interleukin-8 secretion (GO:2000482)2.15462040
196spinal cord motor neuron differentiation (GO:0021522)2.15312130
197positive regulation of meiotic cell cycle (GO:0051446)2.15160698
198regulation of synapse assembly (GO:0051963)2.13935311
199cell differentiation in spinal cord (GO:0021515)2.13427836
200negative regulation of systemic arterial blood pressure (GO:0003085)2.12928877

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.90854347
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.21704709
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.15703405
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.91726044
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.69409876
6GBX2_23144817_ChIP-Seq_PC3_Human3.69234378
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.63638551
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.57491640
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.53101424
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.28877037
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.21973373
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.11134706
13MYC_18358816_ChIP-ChIP_MESCs_Mouse3.09865100
14ZFP57_27257070_Chip-Seq_ESCs_Mouse3.00703523
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.00087428
16EZH2_22144423_ChIP-Seq_EOC_Human2.97197612
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.83215252
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.80853426
19BMI1_23680149_ChIP-Seq_NPCS_Mouse2.79364948
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.78096818
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.75068199
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.59914120
23VDR_23849224_ChIP-Seq_CD4+_Human2.58743164
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.57506543
25GABP_19822575_ChIP-Seq_HepG2_Human2.57259231
26XRN2_22483619_ChIP-Seq_HELA_Human2.57103660
27FLI1_27457419_Chip-Seq_LIVER_Mouse2.52529250
28SRF_21415370_ChIP-Seq_HL-1_Mouse2.49863025
29MYC_19030024_ChIP-ChIP_MESCs_Mouse2.44237318
30FOXP3_21729870_ChIP-Seq_TREG_Human2.43474713
31CBX2_27304074_Chip-Seq_ESCs_Mouse2.42412408
32TAF15_26573619_Chip-Seq_HEK293_Human2.42197492
33DCP1A_22483619_ChIP-Seq_HELA_Human2.40527556
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.39227847
35PCGF2_27294783_Chip-Seq_NPCs_Mouse2.38674254
36SUZ12_27294783_Chip-Seq_NPCs_Mouse2.36329757
37JARID2_20064375_ChIP-Seq_MESCs_Mouse2.31506216
38E2F1_18555785_ChIP-Seq_MESCs_Mouse2.28605581
39EZH2_27304074_Chip-Seq_ESCs_Mouse2.20792875
40NFE2_27457419_Chip-Seq_LIVER_Mouse2.19719362
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18341446
42TTF2_22483619_ChIP-Seq_HELA_Human2.17931514
43EED_16625203_ChIP-ChIP_MESCs_Mouse2.15268473
44POU3F2_20337985_ChIP-ChIP_501MEL_Human2.13674248
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.12066437
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.10745675
47YY1_21170310_ChIP-Seq_MESCs_Mouse2.09354893
48VDR_22108803_ChIP-Seq_LS180_Human2.08642545
49MYC_19079543_ChIP-ChIP_MESCs_Mouse2.06480832
50ELK1_19687146_ChIP-ChIP_HELA_Human2.02811925
51NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02095494
52EZH2_27294783_Chip-Seq_NPCs_Mouse2.01610662
53SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.98238868
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97404165
55E2F4_17652178_ChIP-ChIP_JURKAT_Human1.96728270
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.94571430
57RNF2_27304074_Chip-Seq_NSC_Mouse1.94162453
58FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.92226460
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.89253583
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.88763309
61EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.87705718
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.86541521
63SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.83047392
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.82768307
65SUZ12_18555785_Chip-Seq_ESCs_Mouse1.81768010
66CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.81495792
67P300_19829295_ChIP-Seq_ESCs_Human1.81094413
68STAT3_18555785_Chip-Seq_ESCs_Mouse1.78776760
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.77911350
70P53_22387025_ChIP-Seq_ESCs_Mouse1.77844801
71EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.75746294
72E2F1_18555785_Chip-Seq_ESCs_Mouse1.75479680
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.74019475
74SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.73789469
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72360654
76E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.71840591
77NMYC_18555785_Chip-Seq_ESCs_Mouse1.70067113
78P300_18555785_Chip-Seq_ESCs_Mouse1.69428180
79FUS_26573619_Chip-Seq_HEK293_Human1.68200989
80SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.66621015
81IGF1R_20145208_ChIP-Seq_DFB_Human1.66035451
82JARID2_20075857_ChIP-Seq_MESCs_Mouse1.64855027
83CMYC_18555785_Chip-Seq_ESCs_Mouse1.64506131
84AR_21572438_ChIP-Seq_LNCaP_Human1.62748595
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.62717642
86RUNX1_27457419_Chip-Seq_LIVER_Mouse1.62711395
87CIITA_25753668_ChIP-Seq_RAJI_Human1.61644349
88RNF2_18974828_ChIP-Seq_MESCs_Mouse1.59761334
89EZH2_18974828_ChIP-Seq_MESCs_Mouse1.59761334
90HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59146398
91MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58967676
92OCT4_18555785_Chip-Seq_ESCs_Mouse1.58075649
93RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.57228195
94PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57035352
95POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56920382
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56773546
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.56600877
98ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55672612
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.54989123
100SOX2_18555785_Chip-Seq_ESCs_Mouse1.54274706
101PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53802267
102MYC_18940864_ChIP-ChIP_HL60_Human1.53411573
103KLF4_18555785_Chip-Seq_ESCs_Mouse1.52887254
104HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.52856817
105ZFX_18555785_Chip-Seq_ESCs_Mouse1.52830781
106PIAS1_25552417_ChIP-Seq_VCAP_Human1.52689116
107KDM5A_27292631_Chip-Seq_BREAST_Human1.51808300
108TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50944096
109SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.49658770
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.48478732
111EZH2_27294783_Chip-Seq_ESCs_Mouse1.47485863
112MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.45186526
113CRX_20693478_ChIP-Seq_RETINA_Mouse1.45021611
114PU1_27457419_Chip-Seq_LIVER_Mouse1.45009619
115ESRRB_18555785_Chip-Seq_ESCs_Mouse1.44646289
116IRF1_19129219_ChIP-ChIP_H3396_Human1.44212721
117TP63_19390658_ChIP-ChIP_HaCaT_Human1.44139445
118ER_23166858_ChIP-Seq_MCF-7_Human1.43470679
119TAL1_26923725_Chip-Seq_HPCs_Mouse1.43465468
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.43101275
121SMAD3_21741376_ChIP-Seq_EPCs_Human1.42735557
122SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42704031
123SMAD1_18555785_Chip-Seq_ESCs_Mouse1.42511779
124MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42041246
125EWS_26573619_Chip-Seq_HEK293_Human1.41664685
126YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41188705
127E2F7_22180533_ChIP-Seq_HELA_Human1.40301395
128RNF2_27304074_Chip-Seq_ESCs_Mouse1.39427514
129CTCF_18555785_Chip-Seq_ESCs_Mouse1.39401712
130ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38494816
131OCT4_21477851_ChIP-Seq_ESCs_Mouse1.38423049
132SMAD4_21799915_ChIP-Seq_A2780_Human1.37899320
133UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37868131
134SUZ12_27294783_Chip-Seq_ESCs_Mouse1.37212168
135SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37029857
136E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.37014134
137CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.35067463
138CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34691425
139CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34224486
140DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33421231
141SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.32162175
142SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31546553
143SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.28146528
144TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27749497
145TP53_18474530_ChIP-ChIP_U2OS_Human1.26052902
146SMAD_19615063_ChIP-ChIP_OVARY_Human1.23153583
147CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22627231
148PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19710998
149MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18393727
150CTCF_18555785_ChIP-Seq_MESCs_Mouse1.17585927
151SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17163264
152MTF2_20144788_ChIP-Seq_MESCs_Mouse1.16863557
153OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16749799
154FOXP1_21924763_ChIP-Seq_HESCs_Human1.16560507
155TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14348094
156POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14348094
157KDM2B_26808549_Chip-Seq_REH_Human1.12592333
158PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.12522367
159ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12467251
160SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11844746
161BP1_19119308_ChIP-ChIP_Hs578T_Human1.10849916
162RUNX2_22187159_ChIP-Seq_PCA_Human1.10572389
163SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10355812
164TFEB_21752829_ChIP-Seq_HELA_Human1.09617702
165NOTCH1_21737748_ChIP-Seq_TLL_Human1.08229970
166NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08083627
167CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07352459
168ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05470561
169ELK1_22589737_ChIP-Seq_MCF10A_Human1.05088722
170AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04057838
171KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03616582
172STAT3_23295773_ChIP-Seq_U87_Human1.02923012
173GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02818110
174CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01701364
175YY1_22570637_ChIP-Seq_MALME-3M_Human1.00177331
176SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97558174
177TET1_21451524_ChIP-Seq_MESCs_Mouse0.96958395
178PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.94503670
179NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93887725
180BCL6_27268052_Chip-Seq_Bcells_Human0.88658963
181FOXM1_23109430_ChIP-Seq_U2OS_Human0.88654805
182CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87771566
183TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87439506
184E2F1_21310950_ChIP-Seq_MCF-7_Human0.85584594
185CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85013942
186CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84780152
187ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84145176
188ELF1_20517297_ChIP-Seq_JURKAT_Human0.83340453
189TBX5_21415370_ChIP-Seq_HL-1_Mouse0.82518961
190HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81629569
191FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79977690
192TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.79377646
193CTCF_26484167_Chip-Seq_Bcells_Mouse0.78465710
194TP53_22573176_ChIP-Seq_HFKS_Human0.78152093

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.95575137
2MP0001188_hyperpigmentation4.40332874
3MP0002102_abnormal_ear_morphology3.79369823
4MP0004381_abnormal_hair_follicle3.76186543
5MP0006292_abnormal_olfactory_placode3.67509089
6MP0008789_abnormal_olfactory_epithelium3.30720499
7MP0000566_synostosis3.22169075
8MP0005409_darkened_coat_color3.04332154
9MP0003880_abnormal_central_pattern2.89378546
10MP0003693_abnormal_embryo_hatching2.71044338
11MP0003186_abnormal_redox_activity2.66935004
12MP0003806_abnormal_nucleotide_metabolis2.60477684
13MP0005499_abnormal_olfactory_system2.57571295
14MP0005394_taste/olfaction_phenotype2.57571295
15MP0006036_abnormal_mitochondrial_physio2.42235528
16MP0003123_paternal_imprinting2.33286490
17MP0010094_abnormal_chromosome_stability2.27494043
18MP0005451_abnormal_body_composition2.26661684
19MP0002277_abnormal_respiratory_mucosa2.24859523
20MP0001764_abnormal_homeostasis2.21623441
21MP0003941_abnormal_skin_development2.20242970
22MP0005379_endocrine/exocrine_gland_phen2.19795795
23MP0009379_abnormal_foot_pigmentation2.18001082
24MP0003646_muscle_fatigue2.07068013
25MP0002160_abnormal_reproductive_system2.06380204
26MP0004742_abnormal_vestibular_system2.03013830
27MP0003111_abnormal_nucleus_morphology2.00978530
28MP0006035_abnormal_mitochondrial_morpho1.99283278
29MP0000383_abnormal_hair_follicle1.85752406
30MP0004957_abnormal_blastocyst_morpholog1.84424907
31MP0001986_abnormal_taste_sensitivity1.83755735
32MP0001486_abnormal_startle_reflex1.83140651
33MP0005423_abnormal_somatic_nervous1.78866616
34MP0005645_abnormal_hypothalamus_physiol1.78785433
35MP0008932_abnormal_embryonic_tissue1.76250029
36MP0000015_abnormal_ear_pigmentation1.70720658
37MP0000026_abnormal_inner_ear1.70540779
38MP0005084_abnormal_gallbladder_morpholo1.68856522
39MP0003077_abnormal_cell_cycle1.68206313
40MP0005171_absent_coat_pigmentation1.66962149
41MP0005174_abnormal_tail_pigmentation1.66786061
42MP0003938_abnormal_ear_development1.58255495
43MP0008260_abnormal_autophagy1.58253843
44MP0008995_early_reproductive_senescence1.57181614
45MP0008007_abnormal_cellular_replicative1.56130523
46MP0002837_dystrophic_cardiac_calcinosis1.55864279
47MP0002249_abnormal_larynx_morphology1.54951996
48MP0005389_reproductive_system_phenotype1.52722168
49MP0004142_abnormal_muscle_tone1.52462369
50MP0002822_catalepsy1.51736355
51MP0006276_abnormal_autonomic_nervous1.50486825
52MP0000049_abnormal_middle_ear1.42461928
53MP0003724_increased_susceptibility_to1.41667516
54MP0003121_genomic_imprinting1.39937613
55MP0001968_abnormal_touch/_nociception1.38523271
56MP0001963_abnormal_hearing_physiology1.37540788
57MP0006072_abnormal_retinal_apoptosis1.36441439
58MP0009046_muscle_twitch1.36248292
59MP0001293_anophthalmia1.35692263
60MP0001529_abnormal_vocalization1.35646468
61MP0001905_abnormal_dopamine_level1.35296691
62MP0008058_abnormal_DNA_repair1.35211923
63MP0002653_abnormal_ependyma_morphology1.34228031
64MP0002638_abnormal_pupillary_reflex1.32616914
65MP0002210_abnormal_sex_determination1.31236687
66MP0005646_abnormal_pituitary_gland1.30920873
67MP0000358_abnormal_cell_content/1.30486086
68MP0009697_abnormal_copulation1.27158605
69MP0004133_heterotaxia1.25228395
70MP0002090_abnormal_vision1.24678633
71MP0005075_abnormal_melanosome_morpholog1.24069821
72MP0009250_abnormal_appendicular_skeleto1.19522846
73MP0002938_white_spotting1.18007384
74MP0002234_abnormal_pharynx_morphology1.16590115
75MP0009745_abnormal_behavioral_response1.15548067
76MP0002163_abnormal_gland_morphology1.14903165
77MP0000762_abnormal_tongue_morphology1.13551935
78MP0000631_abnormal_neuroendocrine_gland1.11969378
79MP0005551_abnormal_eye_electrophysiolog1.10655837
80MP0002735_abnormal_chemical_nociception1.09082123
81MP0001929_abnormal_gametogenesis1.08920332
82MP0005332_abnormal_amino_acid1.08291355
83MP0002272_abnormal_nervous_system1.07134324
84MP0005408_hypopigmentation1.07039916
85MP0002067_abnormal_sensory_capabilities1.06896873
86MP0000372_irregular_coat_pigmentation1.06792557
87MP0003718_maternal_effect1.06690137
88MP0005253_abnormal_eye_physiology1.06109960
89MP0002736_abnormal_nociception_after1.05905721
90MP0001485_abnormal_pinna_reflex1.04519633
91MP0001145_abnormal_male_reproductive1.04332146
92MP0003787_abnormal_imprinting1.02054588
93MP0003315_abnormal_perineum_morphology1.01857698
94MP0002876_abnormal_thyroid_physiology1.01762809
95MP0005670_abnormal_white_adipose1.01359577
96MP0002132_abnormal_respiratory_system1.00749304
97MP0002752_abnormal_somatic_nervous0.99905334
98MP0002751_abnormal_autonomic_nervous0.99659391
99MP0000613_abnormal_salivary_gland0.97621831
100MP0003937_abnormal_limbs/digits/tail_de0.96658819
101MP0001727_abnormal_embryo_implantation0.96635893
102MP0000653_abnormal_sex_gland0.95819123
103MP0002557_abnormal_social/conspecific_i0.95639564
104MP0001661_extended_life_span0.95058675
105MP0002572_abnormal_emotion/affect_behav0.94345990
106MP0010678_abnormal_skin_adnexa0.94344636
107MP0002177_abnormal_outer_ear0.94336853
108MP0003698_abnormal_male_reproductive0.91462668
109MP0002095_abnormal_skin_pigmentation0.89532839
110MP0000313_abnormal_cell_death0.89425223
111MP0000778_abnormal_nervous_system0.88600303
112MP0000579_abnormal_nail_morphology0.88304329
113MP0002184_abnormal_innervation0.86475002
114MP0001440_abnormal_grooming_behavior0.86224667
115MP0009053_abnormal_anal_canal0.84553972
116MP0004145_abnormal_muscle_electrophysio0.84411772
117MP0001984_abnormal_olfaction0.84131638
118MP0001501_abnormal_sleep_pattern0.84078967
119MP0000647_abnormal_sebaceous_gland0.83605633
120MP0005367_renal/urinary_system_phenotyp0.82741108
121MP0000516_abnormal_urinary_system0.82741108
122MP0003786_premature_aging0.82093398
123MP0002139_abnormal_hepatobiliary_system0.81046102
124MP0008057_abnormal_DNA_replication0.80968267
125MP0002148_abnormal_hypersensitivity_rea0.79819027
126MP0003119_abnormal_digestive_system0.79784388
127MP0001346_abnormal_lacrimal_gland0.78497966
128MP0000013_abnormal_adipose_tissue0.77831509
129MP0008872_abnormal_physiological_respon0.76873436
130MP0001119_abnormal_female_reproductive0.76834872
131MP0005391_vision/eye_phenotype0.76432975
132MP0000462_abnormal_digestive_system0.75723757
133MP0005083_abnormal_biliary_tract0.74663685
134MP0003950_abnormal_plasma_membrane0.74120520
135MP0005220_abnormal_exocrine_pancreas0.73479940
136MP0003567_abnormal_fetal_cardiomyocyte0.71993366
137MP0002233_abnormal_nose_morphology0.71973286
138MP0009765_abnormal_xenobiotic_induced0.71196178
139MP0002064_seizures0.70451402
140MP0004134_abnormal_chest_morphology0.70051242
141MP0002098_abnormal_vibrissa_morphology0.68492450
142MP0002734_abnormal_mechanical_nocicepti0.67129061
143MP0001286_abnormal_eye_development0.66852070
144MP0001324_abnormal_eye_pigmentation0.66711734
145MP0005195_abnormal_posterior_eye0.66641790
146MP0005266_abnormal_metabolism0.66169677
147MP0010386_abnormal_urinary_bladder0.66114449
148MP0001919_abnormal_reproductive_system0.65479580
149MP0000427_abnormal_hair_cycle0.65267425
150MP0003755_abnormal_palate_morphology0.64773370
151MP0003635_abnormal_synaptic_transmissio0.64528590
152MP0001502_abnormal_circadian_rhythm0.63873957
153MP0001664_abnormal_digestion0.63738360
154MP0003011_delayed_dark_adaptation0.62317447
155MP0000470_abnormal_stomach_morphology0.61808763
156MP0008877_abnormal_DNA_methylation0.60867004
157MP0005410_abnormal_fertilization0.56602330

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.55875341
2Acute necrotizing encephalopathy (HP:0006965)4.88954009
3Chromsome breakage (HP:0040012)4.86138902
4Mitochondrial inheritance (HP:0001427)4.69563670
5Acute encephalopathy (HP:0006846)4.66004225
6Abnormal mitochondria in muscle tissue (HP:0008316)4.65927827
7Increased hepatocellular lipid droplets (HP:0006565)4.61533491
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.44969165
9Hyperglycinemia (HP:0002154)4.29698821
10Hepatocellular necrosis (HP:0001404)4.29585125
11Renal Fanconi syndrome (HP:0001994)4.21350125
12Increased CSF lactate (HP:0002490)4.18905439
13Lipid accumulation in hepatocytes (HP:0006561)4.14559551
14Duplicated collecting system (HP:0000081)4.12093413
15Dynein arm defect of respiratory motile cilia (HP:0012255)4.02338065
16Absent/shortened dynein arms (HP:0200106)4.02338065
17Increased intramyocellular lipid droplets (HP:0012240)3.96573209
18Progressive macrocephaly (HP:0004481)3.93539465
19Hepatic necrosis (HP:0002605)3.91925198
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.88403946
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.88403946
22Upper limb muscle weakness (HP:0003484)3.87360670
23Abnormal ciliary motility (HP:0012262)3.83198867
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.69107735
25Abnormality of the renal collecting system (HP:0004742)3.66805013
26Cerebral edema (HP:0002181)3.59576873
27Septo-optic dysplasia (HP:0100842)3.46543190
28Abnormal respiratory motile cilium physiology (HP:0012261)3.46204294
29Parakeratosis (HP:0001036)3.37177864
30Lactic acidosis (HP:0003128)3.35512102
31Abnormal respiratory epithelium morphology (HP:0012253)3.30238140
32Abnormal respiratory motile cilium morphology (HP:0005938)3.30238140
33Increased muscle lipid content (HP:0009058)3.30005857
34Increased serum lactate (HP:0002151)3.27244146
35Exercise intolerance (HP:0003546)3.19102059
36Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.14442670
37Abnormality of cells of the erythroid lineage (HP:0012130)3.10456067
38Abnormality of the axillary hair (HP:0100134)3.07686167
39Abnormality of secondary sexual hair (HP:0009888)3.07686167
40Exertional dyspnea (HP:0002875)3.05551798
41Respiratory difficulties (HP:0002880)3.03445614
42Microretrognathia (HP:0000308)3.00749287
43Duplication of thumb phalanx (HP:0009942)2.94238122
44Rectovaginal fistula (HP:0000143)2.94202893
45Rectal fistula (HP:0100590)2.94202893
46Abnormality of DNA repair (HP:0003254)2.92644572
47Type I transferrin isoform profile (HP:0003642)2.91589521
48Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.89320495
49Abnormality of midbrain morphology (HP:0002418)2.88017765
50Molar tooth sign on MRI (HP:0002419)2.88017765
51Abnormality of the preputium (HP:0100587)2.78206012
52Reduced antithrombin III activity (HP:0001976)2.75747956
53Respiratory failure (HP:0002878)2.69710430
54Methylmalonic aciduria (HP:0012120)2.69372568
55Abnormal protein glycosylation (HP:0012346)2.68620290
56Abnormal glycosylation (HP:0012345)2.68620290
57Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.68620290
58Abnormal protein N-linked glycosylation (HP:0012347)2.68620290
59Vaginal fistula (HP:0004320)2.63873641
60Reticulocytopenia (HP:0001896)2.63325929
61Aplasia cutis congenita (HP:0001057)2.62314418
62Abnormal number of erythroid precursors (HP:0012131)2.62243011
63Testicular atrophy (HP:0000029)2.58151658
64Prostate neoplasm (HP:0100787)2.51802659
65Febrile seizures (HP:0002373)2.51773038
66Colon cancer (HP:0003003)2.51021085
67White forelock (HP:0002211)2.50156204
68Congenital sensorineural hearing impairment (HP:0008527)2.49814829
69Macrocytic anemia (HP:0001972)2.48528925
70Aplasia/Hypoplasia of the uvula (HP:0010293)2.46040956
71Meckel diverticulum (HP:0002245)2.43476346
72Abnormality of renal resorption (HP:0011038)2.43418418
73Patchy hypopigmentation of hair (HP:0011365)2.42742087
74Absent septum pellucidum (HP:0001331)2.42054609
75Congenital stationary night blindness (HP:0007642)2.40612644
76Optic nerve hypoplasia (HP:0000609)2.40535740
77Concave nail (HP:0001598)2.38922116
78Abnormality of glycine metabolism (HP:0010895)2.38672997
79Abnormality of serine family amino acid metabolism (HP:0010894)2.38672997
80Methylmalonic acidemia (HP:0002912)2.37899878
81Increased serum pyruvate (HP:0003542)2.36868959
82Abnormality of the septum pellucidum (HP:0007375)2.36676196
83Focal motor seizures (HP:0011153)2.35998670
84Decreased central vision (HP:0007663)2.35567281
85Tubulointerstitial nephritis (HP:0001970)2.32023362
86Abnormality of the ileum (HP:0001549)2.31755857
87Conical tooth (HP:0000698)2.31371872
88Anomalous pulmonary venous return (HP:0010772)2.27779639
89Nephroblastoma (Wilms tumor) (HP:0002667)2.27426346
90Abnormality of urine glucose concentration (HP:0011016)2.25937513
91Glycosuria (HP:0003076)2.25937513
92Hyperphosphaturia (HP:0003109)2.25196019
93Attenuation of retinal blood vessels (HP:0007843)2.21478106
94Lethargy (HP:0001254)2.21372459
95Clubbing of toes (HP:0100760)2.19807720
96Abnormality of dicarboxylic acid metabolism (HP:0010995)2.19759775
97Dicarboxylic aciduria (HP:0003215)2.19759775
98Abnormality of incisor morphology (HP:0011063)2.19667996
99Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.17184209
100Abnormality of alanine metabolism (HP:0010916)2.17184209
101Hyperalaninemia (HP:0003348)2.17184209
102Osteomalacia (HP:0002749)2.15860093
103Congenital primary aphakia (HP:0007707)2.15726296
104Leukodystrophy (HP:0002415)2.15355279
105Intestinal fistula (HP:0100819)2.15094159
106Embryonal renal neoplasm (HP:0011794)2.12877900
107Nasolacrimal duct obstruction (HP:0000579)2.12396855
108Optic disc pallor (HP:0000543)2.12267944
109Abnormality of serum amino acid levels (HP:0003112)2.10659333
110Nephrogenic diabetes insipidus (HP:0009806)2.08947565
111Squamous cell carcinoma (HP:0002860)2.06765028
112Bifid tongue (HP:0010297)2.06479985
113Emotional lability (HP:0000712)2.06359419
114Abnormality of the pulmonary veins (HP:0011718)2.06326358
115Gait imbalance (HP:0002141)2.06188169
116Abnormality of glycolysis (HP:0004366)2.05439170
117Submucous cleft hard palate (HP:0000176)2.03804764
118Adrenal hypoplasia (HP:0000835)2.03292863
119CNS demyelination (HP:0007305)2.02073990
120Triphalangeal thumb (HP:0001199)2.00455883
121Median cleft lip (HP:0000161)1.98993761
122Absent rod-and cone-mediated responses on ERG (HP:0007688)1.98752922
123Atelectasis (HP:0100750)1.97840387
124Stenosis of the external auditory canal (HP:0000402)1.97724559
125Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.97328037
126Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96887146
127Rhinitis (HP:0012384)1.96782902
128Abnormality of the nasal septum (HP:0000419)1.95968767
129Nephronophthisis (HP:0000090)1.94901435
130Renal agenesis (HP:0000104)1.94544150
131True hermaphroditism (HP:0010459)1.93830676
132Male pseudohermaphroditism (HP:0000037)1.92976103
133Absent radius (HP:0003974)1.92816176
134Ectopic kidney (HP:0000086)1.91533354
135Aplasia involving forearm bones (HP:0009822)1.90516400
136Absent forearm bone (HP:0003953)1.90516400
137Degeneration of anterior horn cells (HP:0002398)1.89036329
138Abnormality of the anterior horn cell (HP:0006802)1.89036329
139Absent thumb (HP:0009777)1.88680571
140Abnormality of chromosome stability (HP:0003220)1.87772425
141Hyperglycinuria (HP:0003108)1.86800765
142Ragged-red muscle fibers (HP:0003200)1.86637081
143Abnormality of the lacrimal duct (HP:0011481)1.86262699
1443-Methylglutaconic aciduria (HP:0003535)1.85308477
145Lip pit (HP:0100267)1.84926404
146Sex reversal (HP:0012245)1.83534955
147Abnormal sex determination (HP:0012244)1.83534955
148Hypergonadotropic hypogonadism (HP:0000815)1.82436315
149Overfolded helix (HP:0000396)1.82281241
150Microvesicular hepatic steatosis (HP:0001414)1.81951137
151Pallor (HP:0000980)1.81550562
152Obstructive lung disease (HP:0006536)1.80806307
153Chronic obstructive pulmonary disease (HP:0006510)1.80806307
154Aplasia/hypoplasia of the uterus (HP:0008684)1.80093139
155Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80089084
156Abnormal urine phosphate concentration (HP:0012599)1.79993158
157Generalized aminoaciduria (HP:0002909)1.79822078
158Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79042020
159Hypophosphatemic rickets (HP:0004912)1.78165507
160Cutaneous melanoma (HP:0012056)1.77425966
161Abnormality of the renal medulla (HP:0100957)1.76874790
162Increased corneal curvature (HP:0100692)1.76230117
163Keratoconus (HP:0000563)1.76230117
164Medial flaring of the eyebrow (HP:0010747)1.75654072
165Congenital ichthyosiform erythroderma (HP:0007431)1.75302653
166Poikiloderma (HP:0001029)1.75019193
167Brushfield spots (HP:0001088)1.73861488
168Hypoplasia of the pons (HP:0012110)1.73390079
169Preaxial hand polydactyly (HP:0001177)1.73177760
170Abnormality of the nasolacrimal system (HP:0000614)1.72660588
171Prolonged neonatal jaundice (HP:0006579)1.71071437
172Cupped ear (HP:0000378)1.70856870
173Esotropia (HP:0000565)1.70487634
174Partial duplication of thumb phalanx (HP:0009944)1.70444810
175Delayed CNS myelination (HP:0002188)1.70298543
176Abnormality of molar morphology (HP:0011070)1.69558673
177Abnormality of molar (HP:0011077)1.69558673
178Renal cortical cysts (HP:0000803)1.69411439
179X-linked dominant inheritance (HP:0001423)1.69317968
180Abnormality of the pons (HP:0007361)1.66439431
181Humeroradial synostosis (HP:0003041)1.66363910
182Synostosis involving the elbow (HP:0003938)1.66363910
183Gliosis (HP:0002171)1.65466133
184Abnormal hair whorl (HP:0010721)1.65157320
185Abnormality of the dental pulp (HP:0006479)1.65137713
186Short thumb (HP:0009778)1.64927758
187Aplasia of the musculature (HP:0100854)1.64832002
188Hypothermia (HP:0002045)1.63463480
189Hyperammonemia (HP:0001987)1.62167121
190Abnormality of aromatic amino acid family metabolism (HP:0004338)1.62018388
191Aplasia/Hypoplasia of the tibia (HP:0005772)1.62007806
192Abnormality of the parathyroid morphology (HP:0011766)1.58496835

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.60401183
2VRK23.65313260
3NME23.64194871
4BUB13.57244177
5STK163.41514191
6TNIK2.87612563
7BLK2.65048784
8BCKDK2.63793975
9GRK12.60654351
10MKNK22.51275855
11IRAK32.45298836
12TESK22.45038034
13EIF2AK22.15416550
14INSRR2.07796656
15TESK12.05125699
16NEK11.97069951
17LIMK11.95848313
18CDC71.91549255
19CSNK1G31.86593038
20PDK21.83579122
21BMPR1B1.82264785
22SRPK11.81250687
23ADRBK21.79922114
24IRAK41.78073521
25MAP4K21.72325988
26TXK1.68568842
27ARAF1.66961660
28MKNK11.66931078
29TLK11.65127636
30RPS6KA41.64085652
31MUSK1.62728218
32MAP2K71.61673262
33NEK61.59158435
34AURKA1.58698341
35TRIM281.58533997
36PBK1.56742841
37YES11.54362447
38MAPK151.52314983
39GRK71.52114923
40PKN11.47997404
41CSNK1G11.47254262
42ZAK1.44800929
43CSNK1G21.42752749
44IRAK11.41197966
45PLK11.40951568
46MAP3K141.37254006
47IRAK21.36127955
48MAP3K111.33344230
49TNK21.31408800
50VRK11.27579754
51CDK31.27095042
52EIF2AK11.26217425
53MAP3K121.21184399
54CLK11.15257839
55STK391.11854507
56OXSR11.10657387
57PNCK1.08605649
58MAPK131.07880028
59TTK1.07872750
60BRSK11.05287473
61CHEK21.05114608
62KDR0.99708134
63AURKB0.98945891
64NTRK30.92946825
65ABL20.92745499
66PIK3CG0.92385249
67BMPR20.92290505
68PRPF4B0.91061582
69ATR0.90849912
70PLK30.89469528
71DAPK10.88850687
72TEC0.87652248
73FGR0.86670434
74NUAK10.84286596
75NLK0.84207016
76MAP3K40.82877419
77LMTK20.82227064
78PRKCE0.79667811
79DYRK20.78961768
80PRKCI0.78331419
81EPHA40.78282449
82CDK80.77273639
83BCR0.76959266
84BRD40.76007811
85DYRK1B0.75382689
86FES0.73197403
87CSNK2A10.73105140
88AKT30.73057842
89CSNK2A20.72875391
90AKT20.72842764
91MAPKAPK50.70923646
92RPS6KA50.69269366
93STK100.68966144
94DAPK30.67732038
95SIK30.66938413
96NTRK20.66775586
97PAK10.64060693
98STK240.63026114
99TAOK10.60115502
100ILK0.59945936
101DYRK30.59252637
102PIM10.58742444
103CAMK2A0.58645546
104MST40.58580872
105CDK140.58051882
106MARK30.57731875
107PLK20.57345840
108LYN0.55952371
109DYRK1A0.55461392
110NME10.55444896
111LRRK20.55226525
112CSNK1A10.53568114
113CHEK10.53480813
114ADRBK10.53318994
115WEE10.52100087
116MAP3K60.51014304
117NEK20.50950196
118PRKCQ0.50317436
119CAMK2B0.50138661
120BRSK20.47851946
121ATM0.46016279
122PRKG10.45871262
123TAOK20.44167734
124FLT30.42991640
125PLK40.42530693
126EPHA30.42278384
127CAMK10.42235433
128EPHB20.41183110
129PIK3CA0.41046124
130STK38L0.40800063
131WNK30.39438650
132TIE10.39401819
133PRKACA0.38867382
134IKBKB0.38603336
135WNK40.37946299
136RIPK40.37713471
137CSNK1A1L0.37587087
138ERBB30.37347526
139CDK11A0.37058336
140OBSCN0.36155389
141MST1R0.35956877
142PRKCG0.34695744
143MAP3K50.34670618
144CAMK2D0.34480369
145CCNB10.34324965
146SIK20.33511006
147MAPK70.33236683
148MARK10.33218900
149TRPM70.32948178
150CAMKK20.32486422
151PIM20.32483937
152CDK180.32227536
153BRAF0.31896984
154CDK150.31663114
155CDK90.31414204
156SGK10.30901052
157STK40.30787950
158MAP2K40.30713526
159MINK10.30283366
160BTK0.29407291
161CDK190.29108986
162WNK10.28830762
163LCK0.28430667
164CDK70.28117354
165HCK0.27062867
166MAP3K130.26016790
167CAMK2G0.24500136

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.15255043
2Fanconi anemia pathway_Homo sapiens_hsa034603.04698810
3Nicotine addiction_Homo sapiens_hsa050332.73035410
4DNA replication_Homo sapiens_hsa030302.68073933
5Phototransduction_Homo sapiens_hsa047442.67583693
6Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.46642430
7Sulfur relay system_Homo sapiens_hsa041222.30109610
8Base excision repair_Homo sapiens_hsa034102.30089932
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.13559371
10Sphingolipid metabolism_Homo sapiens_hsa006002.01155667
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.92590768
12Homologous recombination_Homo sapiens_hsa034401.91495981
13Spliceosome_Homo sapiens_hsa030401.86809348
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.86301199
15Ether lipid metabolism_Homo sapiens_hsa005651.81391144
16Oxidative phosphorylation_Homo sapiens_hsa001901.78844940
17Non-homologous end-joining_Homo sapiens_hsa034501.74506570
18Arachidonic acid metabolism_Homo sapiens_hsa005901.74178618
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.69798342
20Autoimmune thyroid disease_Homo sapiens_hsa053201.66734251
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.66047929
22Folate biosynthesis_Homo sapiens_hsa007901.64310913
23Ribosome_Homo sapiens_hsa030101.61065981
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.59191481
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.55416777
26RNA polymerase_Homo sapiens_hsa030201.55214476
27Graft-versus-host disease_Homo sapiens_hsa053321.53228316
28Serotonergic synapse_Homo sapiens_hsa047261.52091329
29Basal transcription factors_Homo sapiens_hsa030221.50669417
30One carbon pool by folate_Homo sapiens_hsa006701.50429634
31Linoleic acid metabolism_Homo sapiens_hsa005911.46729276
32Taste transduction_Homo sapiens_hsa047421.44629933
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.43456499
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.42235656
35Morphine addiction_Homo sapiens_hsa050321.37968412
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35983341
37RNA transport_Homo sapiens_hsa030131.33354583
38Fatty acid elongation_Homo sapiens_hsa000621.33091480
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31069570
40Asthma_Homo sapiens_hsa053101.30171700
41Peroxisome_Homo sapiens_hsa041461.29518744
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29229282
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.27671350
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.27385187
45Allograft rejection_Homo sapiens_hsa053301.27160964
46Pyruvate metabolism_Homo sapiens_hsa006201.26659663
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25769790
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.24860769
49Propanoate metabolism_Homo sapiens_hsa006401.24708355
50SNARE interactions in vesicular transport_Homo sapiens_hsa041301.23791676
51Glutathione metabolism_Homo sapiens_hsa004801.22263688
52Hematopoietic cell lineage_Homo sapiens_hsa046401.21729834
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20428155
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.18209074
55Steroid biosynthesis_Homo sapiens_hsa001001.14335526
56Biosynthesis of amino acids_Homo sapiens_hsa012301.12339038
57Rheumatoid arthritis_Homo sapiens_hsa053231.11825223
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.10925186
59Intestinal immune network for IgA production_Homo sapiens_hsa046721.10798881
60Carbon metabolism_Homo sapiens_hsa012001.06726432
61Nucleotide excision repair_Homo sapiens_hsa034201.06115759
62Selenocompound metabolism_Homo sapiens_hsa004501.05948906
63Sulfur metabolism_Homo sapiens_hsa009201.05146477
64NF-kappa B signaling pathway_Homo sapiens_hsa040641.04215018
65Parkinsons disease_Homo sapiens_hsa050121.03833347
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02630225
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.02555004
68Axon guidance_Homo sapiens_hsa043601.00361322
69Alzheimers disease_Homo sapiens_hsa050100.99356112
70Glutamatergic synapse_Homo sapiens_hsa047240.99127471
71Huntingtons disease_Homo sapiens_hsa050160.98779539
72Protein export_Homo sapiens_hsa030600.90706004
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89526803
74Calcium signaling pathway_Homo sapiens_hsa040200.85384055
75Vitamin digestion and absorption_Homo sapiens_hsa049770.85348840
76Pyrimidine metabolism_Homo sapiens_hsa002400.83365157
77Basal cell carcinoma_Homo sapiens_hsa052170.81786447
78Cell cycle_Homo sapiens_hsa041100.80636241
79Histidine metabolism_Homo sapiens_hsa003400.79859470
80Purine metabolism_Homo sapiens_hsa002300.79733030
81Primary immunodeficiency_Homo sapiens_hsa053400.79185112
82Ovarian steroidogenesis_Homo sapiens_hsa049130.75816787
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.73996614
84Malaria_Homo sapiens_hsa051440.73974884
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70271407
86Pentose phosphate pathway_Homo sapiens_hsa000300.70024776
87GABAergic synapse_Homo sapiens_hsa047270.67686801
88Fructose and mannose metabolism_Homo sapiens_hsa000510.67010968
89Butanoate metabolism_Homo sapiens_hsa006500.66117688
90Vibrio cholerae infection_Homo sapiens_hsa051100.65538330
91Other glycan degradation_Homo sapiens_hsa005110.64903273
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.64569441
93Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63228817
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62752254
95Retinol metabolism_Homo sapiens_hsa008300.62434727
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.61407288
97Hedgehog signaling pathway_Homo sapiens_hsa043400.60997274
98Mismatch repair_Homo sapiens_hsa034300.60604558
99Collecting duct acid secretion_Homo sapiens_hsa049660.60107601
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59802790
101Wnt signaling pathway_Homo sapiens_hsa043100.59217980
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.58990904
103Measles_Homo sapiens_hsa051620.58833060
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58392160
105Ras signaling pathway_Homo sapiens_hsa040140.58113174
106Olfactory transduction_Homo sapiens_hsa047400.58022951
107beta-Alanine metabolism_Homo sapiens_hsa004100.54955987
108Fatty acid degradation_Homo sapiens_hsa000710.54636062
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54577590
110p53 signaling pathway_Homo sapiens_hsa041150.54498451
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52802754
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52622618
113Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51645404
114Cardiac muscle contraction_Homo sapiens_hsa042600.51154391
115African trypanosomiasis_Homo sapiens_hsa051430.50981648
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50934201
117RNA degradation_Homo sapiens_hsa030180.50597242
118Long-term depression_Homo sapiens_hsa047300.50583519
119mRNA surveillance pathway_Homo sapiens_hsa030150.50168006
120Cocaine addiction_Homo sapiens_hsa050300.49466975
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49435915
122Fatty acid metabolism_Homo sapiens_hsa012120.49051199
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49046451
124Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48538781
125Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48162612
126Galactose metabolism_Homo sapiens_hsa000520.47761039
127Amphetamine addiction_Homo sapiens_hsa050310.44623330
128Melanoma_Homo sapiens_hsa052180.44401801
129Salivary secretion_Homo sapiens_hsa049700.42644691
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42123394
131Vitamin B6 metabolism_Homo sapiens_hsa007500.41943180
132Systemic lupus erythematosus_Homo sapiens_hsa053220.41862893
133N-Glycan biosynthesis_Homo sapiens_hsa005100.41395820
134Circadian entrainment_Homo sapiens_hsa047130.41372340
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41128146
136ABC transporters_Homo sapiens_hsa020100.40999622
137Renin secretion_Homo sapiens_hsa049240.39215560
138Phagosome_Homo sapiens_hsa041450.37872816
139cAMP signaling pathway_Homo sapiens_hsa040240.37857800
140Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37524556
141Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37042475
142Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36849309
143Chemical carcinogenesis_Homo sapiens_hsa052040.36260486
144Jak-STAT signaling pathway_Homo sapiens_hsa046300.36161434
145Tryptophan metabolism_Homo sapiens_hsa003800.36142330
146Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36016029
147Epstein-Barr virus infection_Homo sapiens_hsa051690.35196865
148Oocyte meiosis_Homo sapiens_hsa041140.35010338
149ECM-receptor interaction_Homo sapiens_hsa045120.34968195
150Metabolic pathways_Homo sapiens_hsa011000.34180032
151Regulation of autophagy_Homo sapiens_hsa041400.34139773
152Vascular smooth muscle contraction_Homo sapiens_hsa042700.32444452
153Glycosaminoglycan degradation_Homo sapiens_hsa005310.30599805
154Arginine and proline metabolism_Homo sapiens_hsa003300.30515418
155Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30303319
156Maturity onset diabetes of the young_Homo sapiens_hsa049500.27396754
157Alcoholism_Homo sapiens_hsa050340.20310956
158Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17983958

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