ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.95845593
2	viral transcription (GO:0019083)	6.38141775
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.21740664
4	translational termination (GO:0006415)	6.16793267
5	establishment of protein localization to mitochondrial membrane (GO:0090151)	6.07411615
6	ATP synthesis coupled proton transport (GO:0015986)	5.53066886
7	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.53066886
8	translational elongation (GO:0006414)	5.34816746
9	maturation of SSU-rRNA (GO:0030490)	5.33185638
10	sequestering of actin monomers (GO:0042989)	5.27965622
11	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.27407814
12	cotranslational protein targeting to membrane (GO:0006613)	5.23498007
13	protein targeting to ER (GO:0045047)	5.13413430
14	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.88713988
15	ribosomal large subunit biogenesis (GO:0042273)	4.88222513
16	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.86973877
17	protein localization to endoplasmic reticulum (GO:0070972)	4.72364735
18	substrate-independent telencephalic tangential migration (GO:0021826)	4.68998845
19	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	4.68998845
20	cellular protein complex disassembly (GO:0043624)	4.66368462
21	ribosomal small subunit biogenesis (GO:0042274)	4.59383800
22	respiratory electron transport chain (GO:0022904)	4.58275182
23	viral life cycle (GO:0019058)	4.58010962
24	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.52587166
25	behavioral response to nicotine (GO:0035095)	4.48724639
26	electron transport chain (GO:0022900)	4.48557800
27	chaperone-mediated protein transport (GO:0072321)	4.44712691
28	neuron fate determination (GO:0048664)	4.09673368
29	lateral sprouting from an epithelium (GO:0060601)	4.08349301
30	translational initiation (GO:0006413)	4.07386695
31	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.00895434
32	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.00895434
33	NADH dehydrogenase complex assembly (GO:0010257)	4.00895434
34	protein complex disassembly (GO:0043241)	3.96286312
35	transmission of nerve impulse (GO:0019226)	3.86133739
36	inner mitochondrial membrane organization (GO:0007007)	3.84504398
37	protein complex biogenesis (GO:0070271)	3.75195381
38	macromolecular complex disassembly (GO:0032984)	3.74563072
39	midbrain development (GO:0030901)	3.59605234
40	somite development (GO:0061053)	3.58797895
41	otic vesicle formation (GO:0030916)	3.56092021
42	dopaminergic neuron differentiation (GO:0071542)	3.47923988
43	positive regulation of gastrulation (GO:2000543)	3.41561799
44	mitochondrial respiratory chain complex assembly (GO:0033108)	3.41259397
45	protein targeting to membrane (GO:0006612)	3.40233119
46	limb bud formation (GO:0060174)	3.21395350
47	negative regulation by host of viral transcription (GO:0043922)	3.18612453
48	translation (GO:0006412)	3.17035765
49	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.10141546
50	cell proliferation in forebrain (GO:0021846)	3.09914120
51	ATP biosynthetic process (GO:0006754)	3.05039304
52	epithelial cilium movement (GO:0003351)	3.00196862
53	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.98861917
54	hydrogen ion transmembrane transport (GO:1902600)	2.98705843
55	arginine metabolic process (GO:0006525)	2.98230991
56	mRNA catabolic process (GO:0006402)	2.93386597
57	neuron fate specification (GO:0048665)	2.86741718
58	spliceosomal complex assembly (GO:0000245)	2.83824902
59	platelet dense granule organization (GO:0060155)	2.83108357
60	protein neddylation (GO:0045116)	2.82832559
61	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.79164954
62	regulation of neurotransmitter uptake (GO:0051580)	2.78753483
63	neuronal stem cell maintenance (GO:0097150)	2.76208171
64	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.76141960
65	lens fiber cell development (GO:0070307)	2.74356679
66	diaphragm development (GO:0060539)	2.74198738
67	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.73651512
68	apical protein localization (GO:0045176)	2.72927672
69	proton transport (GO:0015992)	2.72421356
70	thalamus development (GO:0021794)	2.71999104
71	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.70787318
72	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	2.69998267
73	hydrogen transport (GO:0006818)	2.68995306
74	cellular component biogenesis (GO:0044085)	2.64910789
75	RNA catabolic process (GO:0006401)	2.62849563
76	positive regulation of cell size (GO:0045793)	2.62360748
77	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.61821317
78	keratinization (GO:0031424)	2.61142725
79	arginine catabolic process (GO:0006527)	2.58910698
80	intracellular protein transmembrane import (GO:0044743)	2.58515888
81	skeletal muscle organ development (GO:0060538)	2.57857165
82	nephron epithelium morphogenesis (GO:0072088)	2.56557802
83	nephron tubule morphogenesis (GO:0072078)	2.56557802
84	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.56188995
85	kinetochore assembly (GO:0051382)	2.54161944
86	CTP biosynthetic process (GO:0006241)	2.52837345
87	CTP metabolic process (GO:0046036)	2.52837345
88	protein K6-linked ubiquitination (GO:0085020)	2.52176518
89	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.52122458
90	axon extension involved in axon guidance (GO:0048846)	2.52122458
91	ribonucleoprotein complex biogenesis (GO:0022613)	2.51645519
92	negative regulation of neurotransmitter transport (GO:0051589)	2.50302235
93	exogenous drug catabolic process (GO:0042738)	2.50171625
94	7-methylguanosine mRNA capping (GO:0006370)	2.48438289
95	chromatin remodeling at centromere (GO:0031055)	2.46260582
96	nucleoside triphosphate biosynthetic process (GO:0009142)	2.44717446
97	RNA capping (GO:0036260)	2.43894760
98	7-methylguanosine RNA capping (GO:0009452)	2.43894760
99	CENP-A containing nucleosome assembly (GO:0034080)	2.43141630
100	forebrain neuron differentiation (GO:0021879)	2.41351808

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.57112610
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.50796485
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.41522515
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.87264084
5	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.60567307
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.60167404
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.59352860
8	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.33267393
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.25368258
10	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.19979420
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.15041443
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.14435742
13	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.11702355
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.07128455
15	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.06906060
16	VDR_22108803_ChIP-Seq_LS180_Human	2.01954869
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.99745130
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.98384905
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.92920421
20	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.91451764
21	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.87319213
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.85946726
23	EWS_26573619_Chip-Seq_HEK293_Human	1.80814446
24	FUS_26573619_Chip-Seq_HEK293_Human	1.77136751
25	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.76313404
26	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.74951119
27	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.71161480
28	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.70390090
29	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.69286544
30	RNF2_27304074_Chip-Seq_NSC_Mouse	1.67055616
31	ELK1_19687146_ChIP-ChIP_HELA_Human	1.66889920
32	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.64872850
33	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.63850217
34	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.53876917
35	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.51701900
36	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.50708542
37	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.48227195
38	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.47241075
39	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.46720911
40	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.46720911
41	E2F7_22180533_ChIP-Seq_HELA_Human	1.45540436
42	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.41609545
43	MYC_18940864_ChIP-ChIP_HL60_Human	1.40385786
44	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.39460442
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.38508302
46	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.37353691
47	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.37136198
48	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.34147319
49	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.33680429
50	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.32581321
51	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.32043408
52	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.29934615
53	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.29918508
54	REST_21632747_ChIP-Seq_MESCs_Mouse	1.29760065
55	TP53_22573176_ChIP-Seq_HFKS_Human	1.29352594
56	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.26500462
57	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.25585822
58	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.23995639
59	XRN2_22483619_ChIP-Seq_HELA_Human	1.23866353
60	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23753161
61	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.23612892
62	TTF2_22483619_ChIP-Seq_HELA_Human	1.23128153
63	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.20635330
64	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.19873851
65	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.16885890
66	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.16289880
67	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.13923560
68	AR_21572438_ChIP-Seq_LNCaP_Human	1.13797358
69	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.12986260
70	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.10675996
71	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.09565710
72	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.09053492
73	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.07545614
74	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.07545614
75	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.06989111
76	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.04506377
77	SOX2_19829295_ChIP-Seq_ESCs_Human	1.04258318
78	NANOG_19829295_ChIP-Seq_ESCs_Human	1.04258318
79	P300_19829295_ChIP-Seq_ESCs_Human	1.04239111
80	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.01575364
81	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.00511305
82	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.00013456
83	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.99784459
84	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.99385816
85	ERG_20517297_ChIP-Seq_VCAP_Human	0.98923707
86	ER_23166858_ChIP-Seq_MCF-7_Human	0.98837042
87	AR_25329375_ChIP-Seq_VCAP_Human	0.95272887
88	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.95070622
89	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.94318088
90	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.92254925
91	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.92203310
92	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.90495769
93	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.89850789
94	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.89782296
95	PHF8_20622853_ChIP-Seq_HELA_Human	0.89161963
96	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.88602473
97	VDR_23849224_ChIP-Seq_CD4+_Human	0.88526733
98	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.86071357
99	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.85910480
100	RBPJ_21746931_ChIP-Seq_IB4_Human	0.85442808

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.16182823
2	MP0000566_synostosis	4.97063988
3	MP0003136_yellow_coat_color	3.60387529
4	MP0002234_abnormal_pharynx_morphology	3.31747234
5	MP0004043_abnormal_pH_regulation	2.77211645
6	MP0003880_abnormal_central_pattern	2.65023028
7	MP0001346_abnormal_lacrimal_gland	2.56158746
8	MP0009053_abnormal_anal_canal	2.23466452
9	MP0010030_abnormal_orbit_morphology	2.20849332
10	MP0005645_abnormal_hypothalamus_physiol	2.16277235
11	MP0006292_abnormal_olfactory_placode	2.14238083
12	MP0003283_abnormal_digestive_organ	2.12945319
13	MP0003646_muscle_fatigue	2.10075030
14	MP0002928_abnormal_bile_duct	2.07426734
15	MP0002938_white_spotting	2.02523246
16	MP0004145_abnormal_muscle_electrophysio	2.00727391
17	MP0005084_abnormal_gallbladder_morpholo	1.94791104
18	MP0002277_abnormal_respiratory_mucosa	1.94293079
19	MP0004885_abnormal_endolymph	1.94037368
20	MP0000631_abnormal_neuroendocrine_gland	1.85321817
21	MP0000537_abnormal_urethra_morphology	1.84173208
22	MP0002653_abnormal_ependyma_morphology	1.79688375
23	MP0001529_abnormal_vocalization	1.71643908
24	MP0000778_abnormal_nervous_system	1.68431425
25	MP0003315_abnormal_perineum_morphology	1.62874506
26	MP0003937_abnormal_limbs/digits/tail_de	1.62396349
27	MP0004133_heterotaxia	1.61238046
28	MP0001293_anophthalmia	1.58157935
29	MP0000372_irregular_coat_pigmentation	1.55060854
30	MP0002638_abnormal_pupillary_reflex	1.52259307
31	MP0004142_abnormal_muscle_tone	1.49505429
32	MP0001286_abnormal_eye_development	1.46548364
33	MP0008961_abnormal_basal_metabolism	1.40929116
34	MP0005167_abnormal_blood-brain_barrier	1.40305974
35	MP0003011_delayed_dark_adaptation	1.39623018
36	MP0003938_abnormal_ear_development	1.39189193
37	MP0003718_maternal_effect	1.37647579
38	MP0005423_abnormal_somatic_nervous	1.36657796
39	MP0002233_abnormal_nose_morphology	1.35495224
40	MP0000579_abnormal_nail_morphology	1.33296250
41	MP0000026_abnormal_inner_ear	1.31295487
42	MP0002697_abnormal_eye_size	1.30899149
43	MP0009250_abnormal_appendicular_skeleto	1.29632673
44	MP0001485_abnormal_pinna_reflex	1.21226523
45	MP0002909_abnormal_adrenal_gland	1.19158129
46	MP0009697_abnormal_copulation	1.16771606
47	MP0001919_abnormal_reproductive_system	1.11801514
48	MP0000955_abnormal_spinal_cord	1.11729750
49	MP0002184_abnormal_innervation	1.11704102
50	MP0009745_abnormal_behavioral_response	1.09294114
51	MP0001905_abnormal_dopamine_level	1.08539502
52	MP0003119_abnormal_digestive_system	1.05981667
53	MP0004147_increased_porphyrin_level	1.04666393
54	MP0000467_abnormal_esophagus_morphology	1.03573880
55	MP0008789_abnormal_olfactory_epithelium	1.02027131
56	MP0006276_abnormal_autonomic_nervous	0.96624451
57	MP0008877_abnormal_DNA_methylation	0.95277893
58	MP0003123_paternal_imprinting	0.92399449
59	MP0001879_abnormal_lymphatic_vessel	0.92320846
60	MP0002752_abnormal_somatic_nervous	0.90664954
61	MP0002282_abnormal_trachea_morphology	0.90297437
62	MP0000647_abnormal_sebaceous_gland	0.89768737
63	MP0002095_abnormal_skin_pigmentation	0.89642562
64	MP0002210_abnormal_sex_determination	0.88035267
65	MP0003122_maternal_imprinting	0.87487068
66	MP0005171_absent_coat_pigmentation	0.85824539
67	MP0000049_abnormal_middle_ear	0.84751896
68	MP0002064_seizures	0.82975449
69	MP0002098_abnormal_vibrissa_morphology	0.82919205
70	MP0008058_abnormal_DNA_repair	0.82903056
71	MP0002109_abnormal_limb_morphology	0.81927710
72	MP0002116_abnormal_craniofacial_bone	0.80347477
73	MP0004742_abnormal_vestibular_system	0.79737373
74	MP0005394_taste/olfaction_phenotype	0.79720759
75	MP0005499_abnormal_olfactory_system	0.79720759
76	MP0003121_genomic_imprinting	0.79703387
77	MP0002272_abnormal_nervous_system	0.79108702
78	MP0003693_abnormal_embryo_hatching	0.78264681
79	MP0001984_abnormal_olfaction	0.78060564
80	MP0001440_abnormal_grooming_behavior	0.77980354
81	MP0003861_abnormal_nervous_system	0.77696229
82	MP0006072_abnormal_retinal_apoptosis	0.74617860
83	MP0002572_abnormal_emotion/affect_behav	0.74121021
84	MP0003755_abnormal_palate_morphology	0.73193526
85	MP0005195_abnormal_posterior_eye	0.73141394
86	MP0005187_abnormal_penis_morphology	0.72854347
87	MP0005646_abnormal_pituitary_gland	0.69919758
88	MP0002067_abnormal_sensory_capabilities	0.69218240
89	MP0001486_abnormal_startle_reflex	0.69160537
90	MP0002822_catalepsy	0.67262834
91	MP0002249_abnormal_larynx_morphology	0.67197441
92	MP0003385_abnormal_body_wall	0.66794633
93	MP0003787_abnormal_imprinting	0.65428599
94	MP0005174_abnormal_tail_pigmentation	0.65179823
95	MP0002152_abnormal_brain_morphology	0.64818852
96	MP0003890_abnormal_embryonic-extraembry	0.64686905
97	MP0002736_abnormal_nociception_after	0.64522805
98	MP0002102_abnormal_ear_morphology	0.63338254
99	MP0002063_abnormal_learning/memory/cond	0.62986031
100	MP0002557_abnormal_social/conspecific_i	0.62871538

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Concave nail (HP:0001598)	3.96987165
2	Abnormality of cells of the erythroid lineage (HP:0012130)	3.68070400
3	Acute necrotizing encephalopathy (HP:0006965)	3.59309881
4	Abnormal number of erythroid precursors (HP:0012131)	3.58918863
5	Mitochondrial inheritance (HP:0001427)	3.43382553
6	Reticulocytopenia (HP:0001896)	3.28525688
7	Macrocytic anemia (HP:0001972)	3.20718765
8	Increased hepatocellular lipid droplets (HP:0006565)	3.19290233
9	Septo-optic dysplasia (HP:0100842)	3.10286541
10	Pancreatic cysts (HP:0001737)	3.03724020
11	Abnormal mitochondria in muscle tissue (HP:0008316)	3.02323220
12	Esophageal atresia (HP:0002032)	3.00536576
13	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.91932817
14	Absent septum pellucidum (HP:0001331)	2.91126569
15	Acute encephalopathy (HP:0006846)	2.89570655
16	Renal Fanconi syndrome (HP:0001994)	2.88163932
17	Aplasia/Hypoplasia of the vertebrae (HP:0008515)	2.81311915
18	Vertebral hypoplasia (HP:0008417)	2.81311915
19	True hermaphroditism (HP:0010459)	2.80528847
20	Abnormality of the labia minora (HP:0012880)	2.78325895
21	Nonprogressive disorder (HP:0003680)	2.77636086
22	Progressive macrocephaly (HP:0004481)	2.76834702
23	Partial duplication of the phalanx of hand (HP:0009999)	2.76322086
24	Pancreatic fibrosis (HP:0100732)	2.75163355
25	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.74493077
26	3-Methylglutaconic aciduria (HP:0003535)	2.74250609
27	Lipid accumulation in hepatocytes (HP:0006561)	2.73414533
28	Partial duplication of thumb phalanx (HP:0009944)	2.73397865
29	Congenital, generalized hypertrichosis (HP:0004540)	2.66813769
30	Tubular atrophy (HP:0000092)	2.65673457
31	Increased CSF lactate (HP:0002490)	2.64080353
32	Oligodactyly (hands) (HP:0001180)	2.62116712
33	Split foot (HP:0001839)	2.61958345
34	Abnormality of midbrain morphology (HP:0002418)	2.61832178
35	Molar tooth sign on MRI (HP:0002419)	2.61832178
36	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.60237578
37	Abnormality of the parietal bone (HP:0002696)	2.54530851
38	11 pairs of ribs (HP:0000878)	2.49389651
39	Sparse lateral eyebrow (HP:0005338)	2.49199641
40	Pallor (HP:0000980)	2.47938988
41	Hepatocellular necrosis (HP:0001404)	2.40955528
42	Hepatic necrosis (HP:0002605)	2.39943289
43	Depressed nasal tip (HP:0000437)	2.39056379
44	Morphological abnormality of the inner ear (HP:0011390)	2.39042274
45	Chronic hepatic failure (HP:0100626)	2.38051041
46	Absent thumb (HP:0009777)	2.37743812
47	Abnormal number of incisors (HP:0011064)	2.34493669
48	Abnormality of the septum pellucidum (HP:0007375)	2.31614317
49	Stenosis of the external auditory canal (HP:0000402)	2.30794312
50	Congenital stationary night blindness (HP:0007642)	2.28472184
51	Nephronophthisis (HP:0000090)	2.27542712
52	Type II lissencephaly (HP:0007260)	2.27144311
53	Parakeratosis (HP:0001036)	2.26857051
54	Abnormal respiratory motile cilium physiology (HP:0012261)	2.19076454
55	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.17053769
56	Maternal diabetes (HP:0009800)	2.16481622
57	Abnormality of placental membranes (HP:0011409)	2.16390366
58	Amniotic constriction ring (HP:0009775)	2.16390366
59	Cerebellar dysplasia (HP:0007033)	2.13849718
60	Exertional dyspnea (HP:0002875)	2.12682076
61	Autoimmune thrombocytopenia (HP:0001973)	2.12265563
62	Cerebral edema (HP:0002181)	2.11458712
63	Synostosis involving the elbow (HP:0003938)	2.10061575
64	Humeroradial synostosis (HP:0003041)	2.10061575
65	Hypoplasia of the radius (HP:0002984)	2.07563449
66	Abnormal drinking behavior (HP:0030082)	2.06701719
67	Polydipsia (HP:0001959)	2.06701719
68	Lip pit (HP:0100267)	2.06625978
69	Median cleft lip (HP:0000161)	2.03628357
70	Increased intramyocellular lipid droplets (HP:0012240)	2.03294393
71	Medial flaring of the eyebrow (HP:0010747)	2.03247451
72	Oligodactyly (HP:0012165)	2.02236604
73	Sclerocornea (HP:0000647)	2.02218805
74	Optic disc pallor (HP:0000543)	2.01926574
75	Chronic bronchitis (HP:0004469)	1.98169436
76	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	1.97611741
77	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	1.96839432
78	Lissencephaly (HP:0001339)	1.95353908
79	Anal stenosis (HP:0002025)	1.93864436
80	Intestinal fistula (HP:0100819)	1.93105984
81	Rib fusion (HP:0000902)	1.92772971
82	Erythroderma (HP:0001019)	1.91667842
83	Confusion (HP:0001289)	1.91507555
84	Abnormality of renal resorption (HP:0011038)	1.91416985
85	Hypoplastic labia majora (HP:0000059)	1.89367337
86	Generalized aminoaciduria (HP:0002909)	1.86685557
87	Abnormality of cochlea (HP:0000375)	1.85006090
88	Abnormality of the pons (HP:0007361)	1.81659731
89	Gastrointestinal atresia (HP:0002589)	1.81572927
90	Abnormality of the renal medulla (HP:0100957)	1.79492942
91	Anencephaly (HP:0002323)	1.78380999
92	Sleep apnea (HP:0010535)	1.77685818
93	Abnormality of the 2nd finger (HP:0004100)	1.77462980
94	Sensory axonal neuropathy (HP:0003390)	1.77210839
95	Supernumerary spleens (HP:0009799)	1.74469663
96	Limb dystonia (HP:0002451)	1.72712112
97	Congenital ichthyosiform erythroderma (HP:0007431)	1.72514187
98	Abnormality of the labia majora (HP:0012881)	1.71237327
99	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.70585874
100	Abnormality of the renal cortex (HP:0011035)	1.69706846

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPK15	4.11138565
2	WNK4	3.73074955
3	ZAK	3.61871472
4	STK24	3.51045273
5	PNCK	3.43683454
6	DYRK3	3.10167403
7	STK39	2.72975543
8	VRK2	2.50389180
9	PINK1	2.36518701
10	VRK1	2.34907441
11	NME1	2.17517847
12	TAF1	1.99459499
13	CCNB1	1.89697201
14	CDC7	1.77830811
15	TLK1	1.72199969
16	WNK1	1.71490185
17	TNIK	1.71339912
18	MAP3K2	1.69932975
19	WEE1	1.67561585
20	STK16	1.66965502
21	TYRO3	1.62689090
22	MST4	1.45709469
23	ADRBK2	1.37776828
24	BUB1	1.35862107
25	EPHB2	1.35181626
26	FGFR2	1.33967879
27	NEK2	1.29310002
28	PASK	1.21767696
29	CHEK2	1.21233032
30	MAP3K4	1.19863241
31	MAPKAPK3	1.16816342
32	MAPK13	1.14427349
33	TAOK1	1.13445448
34	NTRK3	1.12246396
35	MKNK1	1.10749897
36	BMPR1B	1.10734324
37	PLK4	1.05568281
38	DYRK2	1.04219892
39	TSSK6	1.03809600
40	BCKDK	1.02567012
41	CDK8	1.02197563
42	NTRK2	0.96727128
43	MKNK2	0.93580213
44	CAMK1	0.91920745
45	CAMKK2	0.90843542
46	WNK3	0.89831024
47	PLK3	0.87024674
48	TGFBR1	0.81936327
49	RPS6KA6	0.77089544
50	GRK1	0.76576643
51	RPS6KA4	0.76176371
52	TESK2	0.72690480
53	EEF2K	0.71659796
54	MARK1	0.69101191
55	MAPKAPK5	0.68763641
56	MINK1	0.68180360
57	EPHA4	0.67390498
58	CDK3	0.67169507
59	RPS6KL1	0.65928324
60	RPS6KC1	0.65928324
61	MAP3K12	0.63928456
62	MAP2K4	0.63071698
63	CAMK4	0.62860199
64	MAP3K3	0.61911236
65	MAP4K2	0.60529892
66	MAP2K7	0.57927372
67	CASK	0.56473702
68	CAMK1G	0.56301838
69	AURKB	0.55607552
70	INSRR	0.54593239
71	PRKCQ	0.54275060
72	TTK	0.54197957
73	CSNK2A2	0.53787106
74	STK11	0.53627963
75	ILK	0.53010309
76	ADRBK1	0.52667297
77	FGFR1	0.49801328
78	OBSCN	0.47620486
79	PHKG2	0.47447915
80	PHKG1	0.47447915
81	PLK1	0.45806990
82	MAP3K11	0.45520687
83	MAP3K6	0.43030628
84	CSNK1E	0.42432050
85	RPS6KB2	0.42093681
86	SRPK1	0.41743822
87	PRKCG	0.39455964
88	CSNK2A1	0.39245597
89	RPS6KA5	0.38120810
90	PRKACA	0.36187933
91	PRKG1	0.35727878
92	KDR	0.35644517
93	AKT2	0.35377146
94	LRRK2	0.35207831
95	AURKA	0.33278364
96	CAMK2A	0.29030109
97	SGK1	0.25998318
98	MAP3K10	0.24586927
99	CSNK1G2	0.24415229
100	TXK	0.21414616

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.57585144
2	Oxidative phosphorylation_Homo sapiens_hsa00190	5.08452596
3	Parkinsons disease_Homo sapiens_hsa05012	4.38916067
4	Huntingtons disease_Homo sapiens_hsa05016	3.31975837
5	Protein export_Homo sapiens_hsa03060	3.28782834
6	Alzheimers disease_Homo sapiens_hsa05010	3.18475634
7	Cardiac muscle contraction_Homo sapiens_hsa04260	3.11800766
8	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.73880986
9	Proteasome_Homo sapiens_hsa03050	2.64947698
10	RNA polymerase_Homo sapiens_hsa03020	2.31706090
11	Phototransduction_Homo sapiens_hsa04744	1.97152050
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.86811565
13	Basal transcription factors_Homo sapiens_hsa03022	1.82880101
14	Homologous recombination_Homo sapiens_hsa03440	1.73397680
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.54072349
16	Nucleotide excision repair_Homo sapiens_hsa03420	1.42727942
17	Olfactory transduction_Homo sapiens_hsa04740	1.40118203
18	One carbon pool by folate_Homo sapiens_hsa00670	1.38282864
19	Spliceosome_Homo sapiens_hsa03040	1.37816505
20	Nitrogen metabolism_Homo sapiens_hsa00910	1.37426422
21	Selenocompound metabolism_Homo sapiens_hsa00450	1.31327939
22	Basal cell carcinoma_Homo sapiens_hsa05217	1.28398120
23	Pyrimidine metabolism_Homo sapiens_hsa00240	1.20354819
24	Folate biosynthesis_Homo sapiens_hsa00790	1.20154000
25	Arginine biosynthesis_Homo sapiens_hsa00220	1.17682866
26	DNA replication_Homo sapiens_hsa03030	1.13497725
27	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.12451569
28	Regulation of autophagy_Homo sapiens_hsa04140	1.10809302
29	Fanconi anemia pathway_Homo sapiens_hsa03460	1.09254872
30	Linoleic acid metabolism_Homo sapiens_hsa00591	1.09012752
31	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.07768776
32	RNA degradation_Homo sapiens_hsa03018	1.03330721
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.01824597
34	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.90407491
35	Cocaine addiction_Homo sapiens_hsa05030	0.86783056
36	Purine metabolism_Homo sapiens_hsa00230	0.85615717
37	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.85247828
38	Mismatch repair_Homo sapiens_hsa03430	0.83315010
39	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.81010663
40	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.79236276
41	RNA transport_Homo sapiens_hsa03013	0.77598710
42	Nicotine addiction_Homo sapiens_hsa05033	0.76351847
43	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.73564990
44	Sulfur metabolism_Homo sapiens_hsa00920	0.71726789
45	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.67262344
46	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.65040358
47	Dopaminergic synapse_Homo sapiens_hsa04728	0.64548112
48	Sulfur relay system_Homo sapiens_hsa04122	0.63962437
49	Axon guidance_Homo sapiens_hsa04360	0.63292852
50	Base excision repair_Homo sapiens_hsa03410	0.62910435
51	Morphine addiction_Homo sapiens_hsa05032	0.59734810
52	mRNA surveillance pathway_Homo sapiens_hsa03015	0.58883310
53	Metabolic pathways_Homo sapiens_hsa01100	0.57906924
54	Cell cycle_Homo sapiens_hsa04110	0.57273864
55	Non-homologous end-joining_Homo sapiens_hsa03450	0.56831971
56	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.56817582
57	Steroid biosynthesis_Homo sapiens_hsa00100	0.55207090
58	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.53038846
59	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.52918721
60	Circadian entrainment_Homo sapiens_hsa04713	0.52565283
61	Pyruvate metabolism_Homo sapiens_hsa00620	0.52466303
62	Taste transduction_Homo sapiens_hsa04742	0.51809314
63	Collecting duct acid secretion_Homo sapiens_hsa04966	0.51448568
64	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.50932691
65	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.50715776
66	Retinol metabolism_Homo sapiens_hsa00830	0.50700116
67	Amphetamine addiction_Homo sapiens_hsa05031	0.50538945
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.49330749
69	Peroxisome_Homo sapiens_hsa04146	0.48445079
70	Wnt signaling pathway_Homo sapiens_hsa04310	0.48185992
71	Hippo signaling pathway_Homo sapiens_hsa04390	0.47897645
72	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.47078251
73	Serotonergic synapse_Homo sapiens_hsa04726	0.44222547
74	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.43927705
75	Butanoate metabolism_Homo sapiens_hsa00650	0.43703749
76	Notch signaling pathway_Homo sapiens_hsa04330	0.42838962
77	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.41309544
78	Arginine and proline metabolism_Homo sapiens_hsa00330	0.41044309
79	Salivary secretion_Homo sapiens_hsa04970	0.40133518
80	Alcoholism_Homo sapiens_hsa05034	0.35866386
81	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.34991751
82	Ether lipid metabolism_Homo sapiens_hsa00565	0.34956697
83	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.33518938
84	Calcium signaling pathway_Homo sapiens_hsa04020	0.33313711
85	Caffeine metabolism_Homo sapiens_hsa00232	0.33113401
86	Melanogenesis_Homo sapiens_hsa04916	0.32707336
87	Propanoate metabolism_Homo sapiens_hsa00640	0.29787750
88	Glutamatergic synapse_Homo sapiens_hsa04724	0.29164386
89	p53 signaling pathway_Homo sapiens_hsa04115	0.28765529
90	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.28211382
91	cAMP signaling pathway_Homo sapiens_hsa04024	0.27869050
92	Tight junction_Homo sapiens_hsa04530	0.27569143
93	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.27267640
94	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.26003643
95	Chemical carcinogenesis_Homo sapiens_hsa05204	0.25879394
96	Primary immunodeficiency_Homo sapiens_hsa05340	0.25741032
97	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.23969142
98	Mineral absorption_Homo sapiens_hsa04978	0.23348050
99	Fat digestion and absorption_Homo sapiens_hsa04975	0.23038905
100	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.23020621

YBX1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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