YBX1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interleukin-6-mediated signaling pathway (GO:0070102)8.45742269
2galactose catabolic process (GO:0019388)7.57598881
3fat-soluble vitamin catabolic process (GO:0042363)7.30278039
4vitamin catabolic process (GO:0009111)7.30278039
5centriole replication (GO:0007099)5.43176303
6rRNA methylation (GO:0031167)5.27966570
7sperm motility (GO:0030317)5.22816443
8single strand break repair (GO:0000012)5.19804679
9negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)5.00425527
10phosphate ion homeostasis (GO:0055062)4.97210933
11trivalent inorganic anion homeostasis (GO:0072506)4.97210933
12microtubule depolymerization (GO:0007019)4.95925596
13positive regulation of T cell cytokine production (GO:0002726)4.74062874
14rRNA modification (GO:0000154)4.71891793
15chromosome condensation (GO:0030261)4.59083023
16response to pheromone (GO:0019236)4.56497476
17regulation of translational termination (GO:0006449)4.54203853
18vitamin D metabolic process (GO:0042359)4.48767582
19cellular anion homeostasis (GO:0030002)4.48365162
20negative regulation of DNA-templated transcription, elongation (GO:0032785)4.43294030
21centriole assembly (GO:0098534)4.42625970
22DNA packaging (GO:0006323)4.38285247
23microtubule polymerization or depolymerization (GO:0031109)4.33996134
24ribosomal large subunit biogenesis (GO:0042273)4.27679287
25regulation of histone H3-K9 methylation (GO:0051570)4.25323359
26regulation of DNA endoreduplication (GO:0032875)4.16850066
27histone exchange (GO:0043486)4.14179085
28acrosome reaction (GO:0007340)4.13686697
29negative regulation of histone methylation (GO:0031061)4.12424082
30galactose metabolic process (GO:0006012)4.05854212
31positive regulation of T-helper 1 type immune response (GO:0002827)4.01107001
32DNA topological change (GO:0006265)4.00351420
33protein-cofactor linkage (GO:0018065)3.99297652
34negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.99225759
35spermatid nucleus differentiation (GO:0007289)3.93086589
36interferon-gamma production (GO:0032609)3.90479762
37regulation of T cell chemotaxis (GO:0010819)3.88976025
38positive regulation of T cell chemotaxis (GO:0010820)3.88976025
39establishment of protein localization to mitochondrial membrane (GO:0090151)3.87186008
40fusion of sperm to egg plasma membrane (GO:0007342)3.83820338
41spermatid development (GO:0007286)3.77629950
42cellular response to interleukin-6 (GO:0071354)3.77014246
43axonemal dynein complex assembly (GO:0070286)3.76787565
44regulation of translational elongation (GO:0006448)3.71917013
45mitotic G2 DNA damage checkpoint (GO:0007095)3.70995015
46positive regulation of type 2 immune response (GO:0002830)3.60845955
47protein targeting to Golgi (GO:0000042)3.58374241
48CENP-A containing nucleosome assembly (GO:0034080)3.57745227
49establishment of protein localization to Golgi (GO:0072600)3.57275839
50negative regulation of gene silencing (GO:0060969)3.53536730
51sperm capacitation (GO:0048240)3.47865038
52mitotic G2/M transition checkpoint (GO:0044818)3.46716241
53apoptotic DNA fragmentation (GO:0006309)3.43053160
54rRNA catabolic process (GO:0016075)3.42957706
55negative regulation of bone mineralization (GO:0030502)3.39538220
56negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.37232931
57regulation of gene silencing by RNA (GO:0060966)3.35670373
58regulation of posttranscriptional gene silencing (GO:0060147)3.35670373
59regulation of gene silencing by miRNA (GO:0060964)3.35670373
60retrograde transport, vesicle recycling within Golgi (GO:0000301)3.33394752
61chromatin remodeling at centromere (GO:0031055)3.32742000
62negative regulation of DNA-dependent DNA replication (GO:2000104)3.32688036
63transcription elongation from RNA polymerase III promoter (GO:0006385)3.30064412
64termination of RNA polymerase III transcription (GO:0006386)3.30064412
65multicellular organism reproduction (GO:0032504)3.29423294
66folic acid transport (GO:0015884)3.25488470
67negative regulation of T cell mediated immunity (GO:0002710)3.25029790
68maturation of SSU-rRNA (GO:0030490)3.19622806
69regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)3.12158703
70regulation of centriole replication (GO:0046599)3.10618136
71sperm-egg recognition (GO:0035036)3.09282541
72lymphocyte chemotaxis (GO:0048247)3.08668155
73positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.08043272
74nucleosome disassembly (GO:0006337)3.07772399
75protein-DNA complex disassembly (GO:0032986)3.07772399
76regulation of mesoderm development (GO:2000380)3.06203305
77response to interleukin-6 (GO:0070741)2.98762636
78protein localization to Golgi apparatus (GO:0034067)2.94375941
79response to redox state (GO:0051775)2.90944017
80epithelial cilium movement (GO:0003351)2.87886108
81negative regulation of transcription regulatory region DNA binding (GO:2000678)2.87598635
82regulation of nuclear cell cycle DNA replication (GO:0033262)2.85745791
83DNA replication-independent nucleosome assembly (GO:0006336)2.84870568
84DNA replication-independent nucleosome organization (GO:0034724)2.84870568
85phosphorelay signal transduction system (GO:0000160)2.83889760
86negative regulation of inclusion body assembly (GO:0090084)2.83398464
87negative regulation of biomineral tissue development (GO:0070168)2.82838117
88inner mitochondrial membrane organization (GO:0007007)2.81677429
89positive regulation of DNA-templated transcription, elongation (GO:0032786)2.81284105
90regulation of T cell cytokine production (GO:0002724)2.80960950
91protein polyglutamylation (GO:0018095)2.79520246
92reproduction (GO:0000003)2.78630659
93mitochondrial respiratory chain complex I assembly (GO:0032981)2.78425373
94NADH dehydrogenase complex assembly (GO:0010257)2.78425373
95mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.78425373
96telomere maintenance via telomerase (GO:0007004)2.78142892
97ribonucleoprotein complex biogenesis (GO:0022613)2.77803101
98chromatin silencing (GO:0006342)2.77341937
99regulation of establishment of cell polarity (GO:2000114)2.76842768
100male meiosis I (GO:0007141)2.74628592

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.15469414
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.85523185
3VDR_22108803_ChIP-Seq_LS180_Human3.46950353
4MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.27002280
5EZH2_22144423_ChIP-Seq_EOC_Human3.09451897
6TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.99769384
7POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.99769384
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.77962837
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.74286816
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.49595429
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.36890758
12ZNF274_21170338_ChIP-Seq_K562_Hela2.30973646
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.30808433
14FUS_26573619_Chip-Seq_HEK293_Human2.25985063
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.07951110
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03371737
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.02182788
18TP63_19390658_ChIP-ChIP_HaCaT_Human1.91419994
19MYC_18940864_ChIP-ChIP_HL60_Human1.85642197
20E2F4_17652178_ChIP-ChIP_JURKAT_Human1.85486234
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.84590983
22TAF15_26573619_Chip-Seq_HEK293_Human1.84027047
23CBP_20019798_ChIP-Seq_JUKART_Human1.76916496
24IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.76916496
25LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76669084
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.76624758
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73597195
28AR_21572438_ChIP-Seq_LNCaP_Human1.70779386
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69154330
30EWS_26573619_Chip-Seq_HEK293_Human1.67101434
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66832413
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.62740500
33MYC_18555785_ChIP-Seq_MESCs_Mouse1.59883390
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.58246109
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.51192569
36E2F7_22180533_ChIP-Seq_HELA_Human1.51021078
37GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.45825738
38EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.42738570
39AUTS2_25519132_ChIP-Seq_293T-REX_Human1.40520843
40RBPJ_21746931_ChIP-Seq_IB4_Human1.36145700
41ERG_20517297_ChIP-Seq_VCAP_Human1.35991148
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.35608229
43TAF2_19829295_ChIP-Seq_ESCs_Human1.34381099
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32956624
45PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.31475896
46NANOG_20526341_ChIP-Seq_ESCs_Human1.30424438
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.28802816
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28802816
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26203126
50TDRD3_21172665_ChIP-Seq_MCF-7_Human1.25811769
51FOXH1_21741376_ChIP-Seq_EPCs_Human1.24547537
52HNFA_21074721_ChIP-Seq_CACO-2_Human1.23662225
53P300_19829295_ChIP-Seq_ESCs_Human1.22709665
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22410707
55WDR5_24793694_ChIP-Seq_LNCAP_Human1.22332006
56NFYB_21822215_ChIP-Seq_K562_Human1.21351777
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21066299
58CBX2_22325352_ChIP-Seq_293T-Rex_Human1.20313434
59ETS1_20019798_ChIP-Seq_JURKAT_Human1.20216317
60ETV1_20927104_ChIP-Seq_GIST48_Human1.19889411
61TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18511864
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16611786
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16539514
64VDR_23849224_ChIP-Seq_CD4+_Human1.16231797
65AR_25329375_ChIP-Seq_VCAP_Human1.16122569
66PHF8_20622853_ChIP-Seq_HELA_Human1.16036872
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14517037
68MYC_19829295_ChIP-Seq_ESCs_Human1.13461613
69CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.11781812
70GATA1_26923725_Chip-Seq_HPCs_Mouse1.11298804
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.11149424
72FOXP3_21729870_ChIP-Seq_TREG_Human1.10795566
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10649553
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10649553
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10649553
76TBL1_22424771_ChIP-Seq_293T_Human1.10425955
77CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.09963256
78PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.08327084
79SOX2_19829295_ChIP-Seq_ESCs_Human1.07774737
80NANOG_19829295_ChIP-Seq_ESCs_Human1.07774737
81GATA3_21878914_ChIP-Seq_MCF-7_Human1.07089075
82FLI1_27457419_Chip-Seq_LIVER_Mouse1.06452842
83NFYA_21822215_ChIP-Seq_K562_Human1.05971916
84MYC_18358816_ChIP-ChIP_MESCs_Mouse1.05505849
85RAC3_21632823_ChIP-Seq_H3396_Human1.05193661
86KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04116962
87MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04096742
88CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03979999
89CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03260560
90HOXB7_26014856_ChIP-Seq_BT474_Human1.03235516
91ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02866469
92BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02577709
93GATA6_21074721_ChIP-Seq_CACO-2_Human1.01593739
94CTCF_20526341_ChIP-Seq_ESCs_Human1.00600878
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00354604
96STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99792119
97VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98356450
98P53_21459846_ChIP-Seq_SAOS-2_Human0.97583321
99SOX2_16153702_ChIP-ChIP_HESCs_Human0.96995555
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96879442

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.65220792
2MP0006292_abnormal_olfactory_placode4.36406640
3MP0002234_abnormal_pharynx_morphology3.61723745
4MP0003646_muscle_fatigue3.41610108
5MP0001764_abnormal_homeostasis3.39738943
6MP0008877_abnormal_DNA_methylation3.22546292
7MP0002396_abnormal_hematopoietic_system2.93867295
8MP0002160_abnormal_reproductive_system2.91148151
9MP0002089_abnormal_postnatal_growth/wei2.69515292
10MP0009053_abnormal_anal_canal2.64785925
11MP0003718_maternal_effect2.53747884
12MP0003136_yellow_coat_color2.43545060
13MP0002736_abnormal_nociception_after2.28802235
14MP0003878_abnormal_ear_physiology2.27090577
15MP0005377_hearing/vestibular/ear_phenot2.27090577
16MP0001293_anophthalmia2.21507258
17MP0001542_abnormal_bone_strength2.16177240
18MP0005389_reproductive_system_phenotype2.14743379
19MP0004957_abnormal_blastocyst_morpholog2.12832899
20MP0004019_abnormal_vitamin_homeostasis2.09503253
21MP0001929_abnormal_gametogenesis1.98473108
22MP0003698_abnormal_male_reproductive1.97946355
23MP0003693_abnormal_embryo_hatching1.94285654
24MP0001968_abnormal_touch/_nociception1.82666907
25MP0004885_abnormal_endolymph1.79477890
26MP0001485_abnormal_pinna_reflex1.77911016
27MP0005310_abnormal_salivary_gland1.73918276
28MP0009379_abnormal_foot_pigmentation1.46045468
29MP0002210_abnormal_sex_determination1.41913703
30MP0000613_abnormal_salivary_gland1.39984142
31MP0002161_abnormal_fertility/fecundity1.38297305
32MP0004742_abnormal_vestibular_system1.37496508
33MP0004142_abnormal_muscle_tone1.37461200
34MP0002909_abnormal_adrenal_gland1.34047606
35MP0000049_abnormal_middle_ear1.32052367
36MP0004043_abnormal_pH_regulation1.31987423
37MP0003315_abnormal_perineum_morphology1.27425515
38MP0010094_abnormal_chromosome_stability1.26920728
39MP0000631_abnormal_neuroendocrine_gland1.25488181
40MP0002277_abnormal_respiratory_mucosa1.22619198
41MP0003938_abnormal_ear_development1.22527990
42MP0001145_abnormal_male_reproductive1.20509476
43MP0002132_abnormal_respiratory_system1.16588369
44MP0005083_abnormal_biliary_tract1.14698402
45MP0003567_abnormal_fetal_cardiomyocyte1.13082531
46MP0002006_tumorigenesis1.12183875
47MP0002233_abnormal_nose_morphology1.10304859
48MP0003077_abnormal_cell_cycle1.09650444
49MP0002272_abnormal_nervous_system1.09202107
50MP0002837_dystrophic_cardiac_calcinosis1.06080939
51MP0001286_abnormal_eye_development1.05018311
52MP0001188_hyperpigmentation1.04872811
53MP0000653_abnormal_sex_gland1.03982839
54MP0005084_abnormal_gallbladder_morpholo1.03874745
55MP0006072_abnormal_retinal_apoptosis1.03754127
56MP0003111_abnormal_nucleus_morphology1.01111103
57MP0003890_abnormal_embryonic-extraembry0.98415930
58MP0000026_abnormal_inner_ear0.97059197
59MP0001919_abnormal_reproductive_system0.95941989
60MP0001765_abnormal_ion_homeostasis0.94690416
61MP0003937_abnormal_limbs/digits/tail_de0.93369866
62MP0001963_abnormal_hearing_physiology0.88333774
63MP0008875_abnormal_xenobiotic_pharmacok0.88055912
64MP0002102_abnormal_ear_morphology0.86888567
65MP0002282_abnormal_trachea_morphology0.86408833
66MP0008872_abnormal_physiological_respon0.84993635
67MP0008932_abnormal_embryonic_tissue0.83407857
68MP0005551_abnormal_eye_electrophysiolog0.81364985
69MP0006036_abnormal_mitochondrial_physio0.79764083
70MP0002067_abnormal_sensory_capabilities0.76530003
71MP0000762_abnormal_tongue_morphology0.75261177
72MP0002085_abnormal_embryonic_tissue0.75176737
73MP0005376_homeostasis/metabolism_phenot0.73467404
74MP0001348_abnormal_lacrimal_gland0.73105697
75MP0003283_abnormal_digestive_organ0.72766924
76MP0000428_abnormal_craniofacial_morphol0.70835943
77MP0006035_abnormal_mitochondrial_morpho0.69654035
78MP0000778_abnormal_nervous_system0.68226580
79MP0005391_vision/eye_phenotype0.66233350
80MP0008058_abnormal_DNA_repair0.65402109
81MP0002084_abnormal_developmental_patter0.65199830
82MP0001984_abnormal_olfaction0.64711318
83MP0002177_abnormal_outer_ear0.63120585
84MP0003861_abnormal_nervous_system0.62554593
85MP0001697_abnormal_embryo_size0.62440319
86MP0005636_abnormal_mineral_homeostasis0.61987092
87MP0001486_abnormal_startle_reflex0.61876379
88MP0000955_abnormal_spinal_cord0.60764506
89MP0003755_abnormal_palate_morphology0.60646269
90MP0003119_abnormal_digestive_system0.59735557
91MP0002752_abnormal_somatic_nervous0.58415309
92MP0000566_synostosis0.57799436
93MP0002733_abnormal_thermal_nociception0.56454343
94MP0009745_abnormal_behavioral_response0.55792250
95MP0002138_abnormal_hepatobiliary_system0.55681990
96MP0005253_abnormal_eye_physiology0.55566694
97MP0005379_endocrine/exocrine_gland_phen0.54973195
98MP0008789_abnormal_olfactory_epithelium0.53098598
99MP0005395_other_phenotype0.51695645
100MP0008057_abnormal_DNA_replication0.51053566

Predicted human phenotypes

RankGene SetZ-score
1Osteomalacia (HP:0002749)7.29014028
2Premature ovarian failure (HP:0008209)4.95837871
3Abnormality of the labia minora (HP:0012880)4.81335811
4Vascular calcification (HP:0004934)4.41147840
5Septo-optic dysplasia (HP:0100842)3.93945930
6Abnormality of renal resorption (HP:0011038)3.92724688
7Cardiovascular calcification (HP:0011915)3.82827949
8Hypergonadotropic hypogonadism (HP:0000815)3.70314942
9Absent/shortened dynein arms (HP:0200106)3.68407250
10Dynein arm defect of respiratory motile cilia (HP:0012255)3.68407250
11Retrobulbar optic neuritis (HP:0100654)3.56484803
12Optic neuritis (HP:0100653)3.56484803
13Abnormal number of erythroid precursors (HP:0012131)3.56357242
14Hyperphosphatemia (HP:0002905)3.38047272
15Abnormality of cells of the erythroid lineage (HP:0012130)3.25756062
16Hypoplastic ischia (HP:0003175)3.14120369
17Abnormal ciliary motility (HP:0012262)2.82017876
18Abnormal urine phosphate concentration (HP:0012599)2.77886469
19Orchitis (HP:0100796)2.75951923
20Abnormal respiratory motile cilium physiology (HP:0012261)2.75072042
21Chromsome breakage (HP:0040012)2.73134570
22Spinal canal stenosis (HP:0003416)2.68471702
23Abnormal respiratory epithelium morphology (HP:0012253)2.65200048
24Abnormal respiratory motile cilium morphology (HP:0005938)2.65200048
25Severe visual impairment (HP:0001141)2.63051686
26Sensory axonal neuropathy (HP:0003390)2.58194213
27Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.57904584
28Abnormality of the ischium (HP:0003174)2.56851132
29Abnormality of renal excretion (HP:0011036)2.52736209
30Optic nerve hypoplasia (HP:0000609)2.49084080
31Maternal diabetes (HP:0009800)2.48655139
32Aplasia/Hypoplasia of the patella (HP:0006498)2.48344026
33Abnormality of lateral ventricle (HP:0030047)2.46122421
34Patellar aplasia (HP:0006443)2.46005742
35Acute necrotizing encephalopathy (HP:0006965)2.42068863
36Absent septum pellucidum (HP:0001331)2.40931508
37Volvulus (HP:0002580)2.38732866
38Nephronophthisis (HP:0000090)2.38476703
39Abnormality of permanent molar morphology (HP:0011071)2.29936347
40Abnormality of the dental root (HP:0006486)2.29936347
41Taurodontia (HP:0000679)2.29936347
42Rickets (HP:0002748)2.20415210
43Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.18507894
44Keratoconjunctivitis sicca (HP:0001097)2.17349772
45Acute encephalopathy (HP:0006846)2.15313453
46Congenital stationary night blindness (HP:0007642)2.12375714
47Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.09951392
48Abnormality of molar morphology (HP:0011070)2.09233666
49Abnormality of molar (HP:0011077)2.09233666
50Myositis (HP:0100614)2.08708683
51Reticulocytopenia (HP:0001896)2.08558769
52Abnormality of the dental pulp (HP:0006479)2.07811764
53Mitochondrial inheritance (HP:0001427)2.06316242
54Molar tooth sign on MRI (HP:0002419)2.01710859
55Abnormality of midbrain morphology (HP:0002418)2.01710859
56Macrocytic anemia (HP:0001972)2.01457380
57Chronic hepatic failure (HP:0100626)10.8763836
58Keratoconjunctivitis (HP:0001096)1.98010923
59Abnormality of placental membranes (HP:0011409)1.96499529
60Amniotic constriction ring (HP:0009775)1.96499529
61Abnormality of DNA repair (HP:0003254)1.95048296
62Azoospermia (HP:0000027)1.93619634
63Hemoptysis (HP:0002105)1.92931045
64Abnormal mitochondria in muscle tissue (HP:0008316)1.92725074
65Rectal fistula (HP:0100590)1.92673852
66Rectovaginal fistula (HP:0000143)1.92673852
67Oligodontia (HP:0000677)1.91549713
68Impulsivity (HP:0100710)1.91443734
69Abnormality of the septum pellucidum (HP:0007375)1.88603481
70Cerebral hypomyelination (HP:0006808)1.88136411
71Tubular atrophy (HP:0000092)1.88115391
72Increased hepatocellular lipid droplets (HP:0006565)1.87033127
733-Methylglutaconic aciduria (HP:0003535)1.86608658
74Bony spicule pigmentary retinopathy (HP:0007737)1.86460035
75Abnormality of the renal medulla (HP:0100957)1.85320227
76Birth length less than 3rd percentile (HP:0003561)1.83559355
77Type II lissencephaly (HP:0007260)1.82505180
78Attenuation of retinal blood vessels (HP:0007843)1.79247044
79Anophthalmia (HP:0000528)1.78075986
80Sparse scalp hair (HP:0002209)1.77720972
81Multiple enchondromatosis (HP:0005701)1.75203735
82Duplicated collecting system (HP:0000081)1.74281836
83Hepatocellular necrosis (HP:0001404)1.73213111
84Pallor (HP:0000980)1.72153751
85Progressive sensorineural hearing impairment (HP:0000408)1.72025489
86Abnormal number of incisors (HP:0011064)1.70734683
87Progressive macrocephaly (HP:0004481)1.70630483
88Hypogonadotrophic hypogonadism (HP:0000044)1.69949671
89Aplasia/Hypoplasia of the earlobes (HP:0009906)1.69157067
90Abnormal spermatogenesis (HP:0008669)1.67485031
91Increased CSF lactate (HP:0002490)1.67438619
92Chromosomal breakage induced by crosslinking agents (HP:0003221)1.66262203
93Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.65666870
94Impaired smooth pursuit (HP:0007772)1.64994113
95Menstrual irregularities (HP:0000858)1.64284706
96Infertility (HP:0000789)1.63834706
97Renal Fanconi syndrome (HP:0001994)1.62390244
98Abnormality of the renal collecting system (HP:0004742)1.61596948
99Abnormal rod and cone electroretinograms (HP:0008323)1.61426396
100Genetic anticipation (HP:0003743)1.61278814

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK35.90926474
2PLK45.19237092
3NEK93.75696423
4CDK123.33788359
5CDC73.22604907
6PNCK2.59964327
7CDK192.46193153
8BRD42.37339292
9PLK22.17505739
10WNK42.13725652
11MAPKAPK51.97416505
12STK391.86046576
13DYRK31.73492180
14TLK11.68161483
15MST41.66466148
16VRK11.51448894
17DDR21.49009861
18VRK21.47029354
19NEK21.42198126
20TSSK61.37836381
21NME11.36204401
22BMPR1B1.35210531
23OXSR11.33702801
24STK161.31829727
25INSRR1.29675924
26TNIK1.26872581
27DYRK1B1.24944256
28MKNK21.24404245
29PLK11.22617121
30IRAK11.20102930
31SRPK11.14787650
32PLK31.14118654
33MAPK151.13821488
34NLK1.11671228
35SGK21.11540910
36TAF11.11286941
37LATS21.10136565
38CDK71.07548786
39SGK2231.04580371
40SGK4941.04580371
41MKNK10.95848194
42WNK10.95796532
43NUAK10.94839878
44TESK10.91546632
45STK38L0.91024575
46NEK10.86986458
47CDK80.81897661
48EEF2K0.81188826
49CDK30.79885976
50ACVR1B0.77586242
51ZAK0.76420560
52DYRK20.75414790
53AURKB0.74434333
54CAMK1G0.72657158
55CHEK10.70728130
56AURKA0.69769392
57MAP2K70.69574980
58MAP4K20.68414729
59ALK0.66426324
60PRKCG0.65267486
61BRSK20.64908363
62RPS6KA50.62347646
63TTK0.62266756
64CSNK1E0.60647845
65SGK10.60327669
66CHEK20.60102244
67MAP3K40.59853595
68AKT30.59792055
69CSNK2A10.59682795
70PIK3CG0.58801722
71PINK10.57258455
72CDK10.57061909
73EPHB20.56792448
74CDK20.55602065
75EIF2AK30.54066027
76MAPKAPK30.53870164
77CSNK2A20.51544269
78ADRBK20.51425108
79UHMK10.49740099
80BCKDK0.46857648
81MAPK140.46841922
82TYRO30.45263901
83RPS6KB20.45097343
84PRKG10.42577454
85JAK30.42012002
86ABL20.41535482
87ATM0.41381340
88CAMK1D0.40066694
89CDK90.39114452
90WNK30.38068641
91RPS6KA40.36434510
92DMPK0.35952741
93RPS6KA10.35780753
94GSK3B0.35539710
95ATR0.34265266
96BRAF0.32526125
97WEE10.32182167
98STK110.31060815
99PDK20.30710465
100PRKCQ0.27684324

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.95488509
2RNA polymerase_Homo sapiens_hsa030203.85717308
3Basal transcription factors_Homo sapiens_hsa030223.70099098
4Protein export_Homo sapiens_hsa030602.87982158
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.70247742
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.61907528
7Ribosome_Homo sapiens_hsa030102.53295505
8Sulfur relay system_Homo sapiens_hsa041222.35448693
9Spliceosome_Homo sapiens_hsa030402.26142554
10DNA replication_Homo sapiens_hsa030302.22190454
11Antigen processing and presentation_Homo sapiens_hsa046122.06551212
12RNA transport_Homo sapiens_hsa030132.00715561
13Mismatch repair_Homo sapiens_hsa034301.89669039
14Huntingtons disease_Homo sapiens_hsa050161.86495363
15Fanconi anemia pathway_Homo sapiens_hsa034601.80669930
16Olfactory transduction_Homo sapiens_hsa047401.76721555
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.67313788
18Oxidative phosphorylation_Homo sapiens_hsa001901.62898980
19Non-homologous end-joining_Homo sapiens_hsa034501.60398981
20Asthma_Homo sapiens_hsa053101.59019858
21Proteasome_Homo sapiens_hsa030501.57802189
22Nucleotide excision repair_Homo sapiens_hsa034201.52867474
23Pyrimidine metabolism_Homo sapiens_hsa002401.52497762
24Parkinsons disease_Homo sapiens_hsa050121.48904906
25Allograft rejection_Homo sapiens_hsa053301.48289615
26Galactose metabolism_Homo sapiens_hsa000521.47913213
27Fatty acid degradation_Homo sapiens_hsa000711.39916513
28Autoimmune thyroid disease_Homo sapiens_hsa053201.37385248
29Cardiac muscle contraction_Homo sapiens_hsa042601.35773107
30Phototransduction_Homo sapiens_hsa047441.32087018
31Selenocompound metabolism_Homo sapiens_hsa004501.23314493
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.23027727
33RNA degradation_Homo sapiens_hsa030181.22892385
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.21994986
35Nicotine addiction_Homo sapiens_hsa050331.21408921
36Purine metabolism_Homo sapiens_hsa002301.21145201
37One carbon pool by folate_Homo sapiens_hsa006701.19524096
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15244425
39Graft-versus-host disease_Homo sapiens_hsa053321.11285773
40Linoleic acid metabolism_Homo sapiens_hsa005911.09713358
41Vitamin digestion and absorption_Homo sapiens_hsa049771.08899389
42Base excision repair_Homo sapiens_hsa034101.07246233
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.04775019
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04508220
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00002877
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99310331
47Melanoma_Homo sapiens_hsa052180.96994228
48Type I diabetes mellitus_Homo sapiens_hsa049400.96406742
49Alzheimers disease_Homo sapiens_hsa050100.94570178
50Caffeine metabolism_Homo sapiens_hsa002320.91425631
51Cell cycle_Homo sapiens_hsa041100.91072717
52Taste transduction_Homo sapiens_hsa047420.88014175
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86650049
54Butanoate metabolism_Homo sapiens_hsa006500.83814688
55Prolactin signaling pathway_Homo sapiens_hsa049170.83754113
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83378804
57mRNA surveillance pathway_Homo sapiens_hsa030150.82976949
58Epstein-Barr virus infection_Homo sapiens_hsa051690.82548220
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78340332
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78280811
61Tyrosine metabolism_Homo sapiens_hsa003500.74857559
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72693546
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66898628
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.66876178
65Pyruvate metabolism_Homo sapiens_hsa006200.66615039
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66492097
67Lysine degradation_Homo sapiens_hsa003100.64321472
68Basal cell carcinoma_Homo sapiens_hsa052170.60806305
69Fatty acid biosynthesis_Homo sapiens_hsa000610.60078240
70Oocyte meiosis_Homo sapiens_hsa041140.58364975
71MAPK signaling pathway_Homo sapiens_hsa040100.55666890
72Systemic lupus erythematosus_Homo sapiens_hsa053220.53838004
73Retinol metabolism_Homo sapiens_hsa008300.52782646
74Tryptophan metabolism_Homo sapiens_hsa003800.49410311
75Ether lipid metabolism_Homo sapiens_hsa005650.49360817
76Nitrogen metabolism_Homo sapiens_hsa009100.49059620
77Folate biosynthesis_Homo sapiens_hsa007900.46253739
78Viral myocarditis_Homo sapiens_hsa054160.45546829
79beta-Alanine metabolism_Homo sapiens_hsa004100.43382057
80Arginine and proline metabolism_Homo sapiens_hsa003300.41970028
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40227703
82Ras signaling pathway_Homo sapiens_hsa040140.39469115
83Metabolic pathways_Homo sapiens_hsa011000.38972039
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38793442
85Fat digestion and absorption_Homo sapiens_hsa049750.38423872
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.38388473
87Glutamatergic synapse_Homo sapiens_hsa047240.38260770
88Propanoate metabolism_Homo sapiens_hsa006400.38155823
89Morphine addiction_Homo sapiens_hsa050320.37665021
90Mineral absorption_Homo sapiens_hsa049780.37425198
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37312020
92Chemical carcinogenesis_Homo sapiens_hsa052040.36132946
93Chemokine signaling pathway_Homo sapiens_hsa040620.33294693
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.30694413
95Hedgehog signaling pathway_Homo sapiens_hsa043400.30391008
96Primary immunodeficiency_Homo sapiens_hsa053400.30289005
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28992961
98Herpes simplex infection_Homo sapiens_hsa051680.27732886
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26113844
100Histidine metabolism_Homo sapiens_hsa003400.24523025

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