YBX1P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-serine metabolic process (GO:0006563)7.39212776
2nucleoside transmembrane transport (GO:1901642)6.00832764
3pyrimidine nucleobase catabolic process (GO:0006208)5.74470852
4platelet dense granule organization (GO:0060155)5.52350266
5striatum development (GO:0021756)5.39533912
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.29743396
7embryonic digestive tract development (GO:0048566)5.26745966
8alanine transport (GO:0032328)5.01909239
9protein-cofactor linkage (GO:0018065)4.99124409
10cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.99028649
11cytidine deamination (GO:0009972)4.83148135
12cytidine metabolic process (GO:0046087)4.83148135
13cytidine catabolic process (GO:0006216)4.83148135
14serine family amino acid biosynthetic process (GO:0009070)4.68928763
15protein localization to cilium (GO:0061512)4.52634012
16outflow tract septum morphogenesis (GO:0003148)4.50837223
17secretory granule organization (GO:0033363)4.39561629
18nucleobase catabolic process (GO:0046113)4.32229218
19positive regulation of protein kinase C signaling (GO:0090037)4.23299930
20pyrimidine ribonucleoside catabolic process (GO:0046133)4.10447005
21behavioral response to ethanol (GO:0048149)3.99694589
22regulation of MHC class I biosynthetic process (GO:0045343)3.86776743
23lipopolysaccharide metabolic process (GO:0008653)3.75580770
24nucleoside transport (GO:0015858)3.73358038
25chemosensory behavior (GO:0007635)3.72235700
26retinoic acid receptor signaling pathway (GO:0048384)3.71245868
27positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.69740838
28mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.69740838
29DNA deamination (GO:0045006)3.68485653
30polyamine biosynthetic process (GO:0006596)3.65882410
31lipopolysaccharide biosynthetic process (GO:0009103)3.57685337
32intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.46678626
33mitochondrial DNA replication (GO:0006264)3.41113571
34iron-sulfur cluster assembly (GO:0016226)3.37748601
35metallo-sulfur cluster assembly (GO:0031163)3.37748601
36regulation of penile erection (GO:0060405)3.33880066
37C4-dicarboxylate transport (GO:0015740)3.30705635
38centriole replication (GO:0007099)3.25019495
39negative regulation of interleukin-1 production (GO:0032692)3.09471433
40negative regulation of translation, ncRNA-mediated (GO:0040033)3.06869593
41regulation of translation, ncRNA-mediated (GO:0045974)3.06869593
42negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.06869593
43histone H3-K4 trimethylation (GO:0080182)3.05163653
44regulation of pigment cell differentiation (GO:0050932)3.04033450
45intestinal cholesterol absorption (GO:0030299)3.02337280
46T cell migration (GO:0072678)3.01160970
47positive regulation of CREB transcription factor activity (GO:0032793)2.92501480
48mitochondrial DNA metabolic process (GO:0032042)2.91933423
49positive regulation of defense response to virus by host (GO:0002230)2.91882421
50melanin metabolic process (GO:0006582)2.90918542
51negative regulation of membrane potential (GO:0045837)2.88429237
52regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.88142823
53regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.88142823
54cysteine metabolic process (GO:0006534)2.87832423
55melanin biosynthetic process (GO:0042438)2.85899238
56one-carbon compound transport (GO:0019755)2.83538568
57cellular response to ATP (GO:0071318)2.80899133
58tumor necrosis factor-mediated signaling pathway (GO:0033209)2.80194189
59righting reflex (GO:0060013)2.79750437
60regulation of myelination (GO:0031641)2.79059491
61histone H2A acetylation (GO:0043968)2.78080183
62insulin-like growth factor receptor signaling pathway (GO:0048009)2.75479596
63basic amino acid transport (GO:0015802)2.71195363
64secondary metabolite biosynthetic process (GO:0044550)2.70507903
65protein K48-linked deubiquitination (GO:0071108)2.69230098
66DNA demethylation (GO:0080111)2.69043334
67anterograde synaptic vesicle transport (GO:0048490)2.68581599
68thrombin receptor signaling pathway (GO:0070493)2.68351980
69cellular biogenic amine biosynthetic process (GO:0042401)2.68008798
70L-glutamate transport (GO:0015813)2.67143039
71signal peptide processing (GO:0006465)2.66671144
72regulation of interleukin-12 biosynthetic process (GO:0045075)2.63757960
73release of sequestered calcium ion into cytosol (GO:0051209)2.62225318
74negative regulation of sequestering of calcium ion (GO:0051283)2.62225318
75positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.61114139
76mitochondrial calcium ion transport (GO:0006851)2.60364019
77N-terminal protein amino acid acetylation (GO:0006474)2.59745567
78neuronal action potential (GO:0019228)2.57767513
79positive regulation of protein sumoylation (GO:0033235)2.57057044
80regulation of hippo signaling (GO:0035330)2.56538390
81positive regulation of prostaglandin secretion (GO:0032308)2.55072496
82negative regulation of heart rate (GO:0010459)2.54325869
83positive regulation of mitochondrial fission (GO:0090141)2.51600464
84glandular epithelial cell development (GO:0002068)2.50066693
85cardiac muscle cell differentiation (GO:0055007)2.49946590
86blood vessel maturation (GO:0001955)2.49262162
87negative regulation of Rho protein signal transduction (GO:0035024)2.48633389
88behavioral response to nicotine (GO:0035095)2.48305534
89endosome to melanosome transport (GO:0035646)2.47957142
90endosome to pigment granule transport (GO:0043485)2.47957142
91peroxisome fission (GO:0016559)2.47393588
92pyrimidine-containing compound catabolic process (GO:0072529)2.46751188
93positive regulation of histone deacetylation (GO:0031065)2.46196556
94acidic amino acid transport (GO:0015800)2.46021570
95interferon-gamma production (GO:0032609)2.45800884
96amine biosynthetic process (GO:0009309)2.45005344
97kynurenine metabolic process (GO:0070189)2.44948120
98negative regulation of interleukin-1 beta production (GO:0032691)2.44741570
99serine family amino acid metabolic process (GO:0009069)2.44044652
100developmental pigmentation (GO:0048066)2.42993402

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human9.28008726
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse5.31482545
3CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons4.38154957
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.27758836
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.95416163
6ZNF274_21170338_ChIP-Seq_K562_Hela3.58329839
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.46565767
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.97377349
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.77507244
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.64295277
11IRF1_19129219_ChIP-ChIP_H3396_Human2.62389945
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.56116549
13TP53_16413492_ChIP-PET_HCT116_Human2.50039629
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.35994568
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32149821
16SCL_19346495_ChIP-Seq_HPC-7_Human1.98449935
17SALL1_21062744_ChIP-ChIP_HESCs_Human1.97818762
18TAF15_26573619_Chip-Seq_HEK293_Human1.83151114
19GATA1_26923725_Chip-Seq_HPCs_Mouse1.78014909
20CIITA_25753668_ChIP-Seq_RAJI_Human1.73594222
21FOXM1_23109430_ChIP-Seq_U2OS_Human1.72303439
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.66774754
23NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.65322729
24CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.59113283
25GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.58162660
26LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.58114415
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.55467711
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47240094
29MAF_26560356_Chip-Seq_TH2_Human1.44560578
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.44049578
31VDR_23849224_ChIP-Seq_CD4+_Human1.43263592
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.42709254
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35730601
34AR_21572438_ChIP-Seq_LNCaP_Human1.32875631
35MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.31418133
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.29051142
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.28012688
38IGF1R_20145208_ChIP-Seq_DFB_Human1.26556688
39ER_23166858_ChIP-Seq_MCF-7_Human1.26035169
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.22361298
41DROSHA_22980978_ChIP-Seq_HELA_Human1.21679971
42IRF8_21731497_ChIP-ChIP_J774_Mouse1.19211513
43STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.17913455
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17307102
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17219884
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16670809
47RUNX_20019798_ChIP-Seq_JUKART_Human1.16276715
48UTX_26944678_Chip-Seq_JUKART_Human1.13519692
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11500680
50GATA3_26560356_Chip-Seq_TH2_Human1.09863445
51E2F1_17053090_ChIP-ChIP_MCF-7_Human1.07940205
52ERA_21632823_ChIP-Seq_H3396_Human1.06780382
53AHR_22903824_ChIP-Seq_MCF-7_Human1.06465579
54PKCTHETA_26484144_Chip-Seq_BREAST_Human1.04917969
55MAF_26560356_Chip-Seq_TH1_Human1.03383611
56FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.01208721
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01006642
58GABP_19822575_ChIP-Seq_HepG2_Human1.00465166
59CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00378370
60CBP_20019798_ChIP-Seq_JUKART_Human0.99708296
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99708296
62NCOR_22424771_ChIP-Seq_293T_Human0.98452465
63EWS_26573619_Chip-Seq_HEK293_Human0.98256838
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97693176
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96730855
66NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.92775109
67GATA3_27048872_Chip-Seq_THYMUS_Human0.92247636
68MYC_22102868_ChIP-Seq_BL_Human0.92174670
69BCL6_27268052_Chip-Seq_Bcells_Human0.91228947
70FUS_26573619_Chip-Seq_HEK293_Human0.89043495
71SPI1_23547873_ChIP-Seq_NB4_Human0.88476081
72SMAD3_21741376_ChIP-Seq_EPCs_Human0.84566868
73SMRT_27268052_Chip-Seq_Bcells_Human0.84550485
74YY1_21170310_ChIP-Seq_MESCs_Mouse0.84282783
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.83980161
76STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83738805
77MYC_19829295_ChIP-Seq_ESCs_Human0.83284411
78MITF_21258399_ChIP-Seq_MELANOMA_Human0.82662135
79CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.82332219
80AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81078960
81TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.80684291
82RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.79011842
83RUNX1_22412390_ChIP-Seq_EML_Mouse0.77309241
84MYB_26560356_Chip-Seq_TH2_Human0.77163186
85RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.76976572
86E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.76135140
87PRDM14_20953172_ChIP-Seq_ESCs_Human0.76117444
88BCAT_22108803_ChIP-Seq_LS180_Human0.75794058
89RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.75251053
90E2F4_17652178_ChIP-ChIP_JURKAT_Human0.74682385
91MYB_26560356_Chip-Seq_TH1_Human0.74243580
92AR_25329375_ChIP-Seq_VCAP_Human0.74082641
93RAC3_21632823_ChIP-Seq_H3396_Human0.73996341
94TCF4_22108803_ChIP-Seq_LS180_Human0.73723645
95GATA1_19941827_ChIP-Seq_MEL_Mouse0.72960409
96KDM2B_26808549_Chip-Seq_REH_Human0.72787340
97EGR1_23403033_ChIP-Seq_LIVER_Mouse0.71975499
98MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.71396654
99FLI1_21867929_ChIP-Seq_TH2_Mouse0.71309191
100ETS1_20019798_ChIP-Seq_JURKAT_Human0.71165028

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005248_abnormal_Harderian_gland6.03599699
2MP0010030_abnormal_orbit_morphology4.32439256
3MP0000015_abnormal_ear_pigmentation4.26308547
4MP0003136_yellow_coat_color3.70684867
5MP0005174_abnormal_tail_pigmentation3.62520919
6MP0008260_abnormal_autophagy3.31540842
7MP0003880_abnormal_central_pattern2.90284726
8MP0005083_abnormal_biliary_tract2.88824108
9MP0004381_abnormal_hair_follicle2.63847021
10MP0003646_muscle_fatigue2.40318195
11MP0003806_abnormal_nucleotide_metabolis2.39600467
12MP0002102_abnormal_ear_morphology2.32170972
13MP0005409_darkened_coat_color2.31115187
14MP0000569_abnormal_digit_pigmentation2.10895921
15MP0003329_amyloid_beta_deposits2.09069567
16MP0001986_abnormal_taste_sensitivity2.01716287
17MP0002249_abnormal_larynx_morphology1.98478470
18MP0005171_absent_coat_pigmentation1.85160040
19MP0002095_abnormal_skin_pigmentation1.83791844
20MP0005623_abnormal_meninges_morphology1.78445150
21MP0001188_hyperpigmentation1.75851324
22MP0005423_abnormal_somatic_nervous1.64843649
23MP0002282_abnormal_trachea_morphology1.54316384
24MP0003656_abnormal_erythrocyte_physiolo1.49739375
25MP0002396_abnormal_hematopoietic_system1.47941609
26MP0002332_abnormal_exercise_endurance1.38728032
27MP0008057_abnormal_DNA_replication1.38493254
28MP0005084_abnormal_gallbladder_morpholo1.35412525
29MP0010094_abnormal_chromosome_stability1.33526039
30MP0000371_diluted_coat_color1.31353310
31MP0001968_abnormal_touch/_nociception1.30459374
32MP0008058_abnormal_DNA_repair1.25922512
33MP0005671_abnormal_response_to1.24488900
34MP0009697_abnormal_copulation1.21007277
35MP0000750_abnormal_muscle_regeneration1.20070345
36MP0005266_abnormal_metabolism1.18416598
37MP0003221_abnormal_cardiomyocyte_apopto1.18038220
38MP0003567_abnormal_fetal_cardiomyocyte1.13726739
39MP0000372_irregular_coat_pigmentation1.12008495
40MP0001984_abnormal_olfaction1.10924101
41MP0000604_amyloidosis1.10163312
42MP0002736_abnormal_nociception_after1.09956808
43MP0005197_abnormal_uvea_morphology1.06985397
44MP0000566_synostosis1.06908650
45MP0000647_abnormal_sebaceous_gland1.05907720
46MP0001958_emphysema1.04165085
47MP0003252_abnormal_bile_duct1.04102700
48MP0003111_abnormal_nucleus_morphology1.03841101
49MP0000613_abnormal_salivary_gland1.03714039
50MP0002168_other_aberrant_phenotype1.00020501
51MP0001485_abnormal_pinna_reflex0.98926661
52MP0009046_muscle_twitch0.98095167
53MP0001542_abnormal_bone_strength0.98083015
54MP0000427_abnormal_hair_cycle0.96297594
55MP0005508_abnormal_skeleton_morphology0.96235170
56MP0003436_decreased_susceptibility_to0.95956387
57MP0010307_abnormal_tumor_latency0.94629526
58MP0005377_hearing/vestibular/ear_phenot0.93582755
59MP0003878_abnormal_ear_physiology0.93582755
60MP0006082_CNS_inflammation0.93230465
61MP0003632_abnormal_nervous_system0.90808292
62MP0005075_abnormal_melanosome_morpholog0.89836684
63MP0002405_respiratory_system_inflammati0.88900255
64MP0002419_abnormal_innate_immunity0.87808592
65MP0000358_abnormal_cell_content/0.87721858
66MP0000383_abnormal_hair_follicle0.87310273
67MP0001324_abnormal_eye_pigmentation0.86569223
68MP0001486_abnormal_startle_reflex0.86199123
69MP0004484_altered_response_of0.85584412
70MP0004133_heterotaxia0.84851979
71MP0002928_abnormal_bile_duct0.84166800
72MP0006035_abnormal_mitochondrial_morpho0.81347844
73MP0001800_abnormal_humoral_immune0.80142485
74MP0000703_abnormal_thymus_morphology0.78892558
75MP0005647_abnormal_sex_gland0.77696960
76MP0002075_abnormal_coat/hair_pigmentati0.77550572
77MP0004233_abnormal_muscle_weight0.77515145
78MP0005253_abnormal_eye_physiology0.77408294
79MP0004742_abnormal_vestibular_system0.77371222
80MP0002723_abnormal_immune_serum0.76911563
81MP0002420_abnormal_adaptive_immunity0.74970066
82MP0000538_abnormal_urinary_bladder0.73773734
83MP0003868_abnormal_feces_composition0.72365932
84MP0004130_abnormal_muscle_cell0.69717409
85MP0002970_abnormal_white_adipose0.69296829
86MP0008873_increased_physiological_sensi0.68852912
87MP0009278_abnormal_bone_marrow0.68817004
88MP0001819_abnormal_immune_cell0.68810177
89MP0005376_homeostasis/metabolism_phenot0.67814205
90MP0003195_calcinosis0.66771407
91MP0008007_abnormal_cellular_replicative0.66404663
92MP0000516_abnormal_urinary_system0.64266657
93MP0005367_renal/urinary_system_phenotyp0.64266657
94MP0003279_aneurysm0.63410787
95MP0005000_abnormal_immune_tolerance0.62816743
96MP0003763_abnormal_thymus_physiology0.62746775
97MP0001191_abnormal_skin_condition0.60360149
98MP0005387_immune_system_phenotype0.60078218
99MP0001790_abnormal_immune_system0.60078218
100MP0002452_abnormal_antigen_presenting0.60008133

Predicted human phenotypes

RankGene SetZ-score
1Abnormal pancreas size (HP:0012094)6.35866681
2Annular pancreas (HP:0001734)6.33270455
3Chronic hepatic failure (HP:0100626)4.35790377
4Poikiloderma (HP:0001029)4.27492420
5Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.12290089
6Carpal bone hypoplasia (HP:0001498)4.04642371
7Entropion (HP:0000621)3.63936793
8Stomatitis (HP:0010280)3.49098090
9Small epiphyses (HP:0010585)3.43159086
10Genetic anticipation (HP:0003743)3.39456666
11Fibular aplasia (HP:0002990)3.35729975
12Broad face (HP:0000283)3.29494494
13Birth length less than 3rd percentile (HP:0003561)3.28608067
14Squamous cell carcinoma (HP:0002860)3.18199741
15Acute hepatic failure (HP:0006554)3.18037062
16Abnormal lung lobation (HP:0002101)2.87338324
17Hypoplasia of the thymus (HP:0000778)2.84327778
18Bicornuate uterus (HP:0000813)2.83451096
19Abnormality of the astrocytes (HP:0100707)2.77160140
20Astrocytoma (HP:0009592)2.77160140
21Abnormality of glycolipid metabolism (HP:0010969)2.75315599
22Abnormality of liposaccharide metabolism (HP:0010968)2.75315599
23Abnormality of glycosphingolipid metabolism (HP:0004343)2.75315599
24Depressed nasal tip (HP:0000437)2.65298192
25Pancreatic cysts (HP:0001737)2.56255213
26Hypoplastic pelvis (HP:0008839)2.56034977
27Abnormality of the nasal septum (HP:0000419)2.41954837
28Distal lower limb amyotrophy (HP:0008944)2.39464053
29Molar tooth sign on MRI (HP:0002419)2.38449979
30Abnormality of midbrain morphology (HP:0002418)2.38449979
31Lissencephaly (HP:0001339)2.38422685
32Eosinophilia (HP:0001880)2.37755309
33Hyperventilation (HP:0002883)2.36756496
34Patellar aplasia (HP:0006443)2.36019020
35Anophthalmia (HP:0000528)2.34454753
36Epidermoid cyst (HP:0200040)2.33201667
37Lower limb amyotrophy (HP:0007210)2.29771850
38Duodenal stenosis (HP:0100867)2.28169072
39Small intestinal stenosis (HP:0012848)2.28169072
40Decreased electroretinogram (ERG) amplitude (HP:0000654)2.26059066
41Agnosia (HP:0010524)2.21813544
42Abnormal tarsal ossification (HP:0008369)2.17739688
43Progressive inability to walk (HP:0002505)2.15179354
44Dysautonomia (HP:0002459)2.15035649
45Abnormal hair whorl (HP:0010721)2.13368933
46Ependymoma (HP:0002888)2.12667682
47Broad nasal tip (HP:0000455)2.11210972
48Abnormal delayed hypersensitivity skin test (HP:0002963)2.11196920
49Stomach cancer (HP:0012126)2.08701443
50Aplasia/Hypoplasia of the patella (HP:0006498)2.08466010
51Glioma (HP:0009733)2.07537062
52Freckling (HP:0001480)2.01772171
53Medial flaring of the eyebrow (HP:0010747)2.01053380
54Tracheomalacia (HP:0002779)2.00784381
55Ocular albinism (HP:0001107)1.99149791
56Small hand (HP:0200055)1.98922320
57Impulsivity (HP:0100710)1.96988797
58Autoimmune thrombocytopenia (HP:0001973)1.95217848
59Esotropia (HP:0000565)1.95161257
60Progressive cerebellar ataxia (HP:0002073)1.94863562
61Dyskinesia (HP:0100660)1.94812078
62Urinary bladder sphincter dysfunction (HP:0002839)1.92731979
63Autoimmune hemolytic anemia (HP:0001890)1.91446950
64Abnormality of eosinophils (HP:0001879)1.89304048
65Abnormal auditory evoked potentials (HP:0006958)1.86160514
66Macular degeneration (HP:0000608)1.85164996
67Nephrogenic diabetes insipidus (HP:0009806)1.84215655
68Gait imbalance (HP:0002141)1.83841890
69Degeneration of the lateral corticospinal tracts (HP:0002314)1.83163050
70Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.83163050
71Partial agenesis of the corpus callosum (HP:0001338)1.81715612
72Aplasia/Hypoplasia of the fibula (HP:0006492)1.80724751
73Parakeratosis (HP:0001036)1.80696765
74Spastic tetraplegia (HP:0002510)1.79656033
75Natal tooth (HP:0000695)1.78694210
76Congenital primary aphakia (HP:0007707)1.78687242
77Basal cell carcinoma (HP:0002671)1.78228930
78True hermaphroditism (HP:0010459)1.76318769
79Cutaneous photosensitivity (HP:0000992)1.76105521
80Congenital stationary night blindness (HP:0007642)1.74886579
81Fibular hypoplasia (HP:0003038)1.74479340
82Abnormality of the renal cortex (HP:0011035)1.74379739
83Granulocytopenia (HP:0001913)1.73521959
84Barrel-shaped chest (HP:0001552)1.71846012
85Irregular vertebral endplates (HP:0003301)1.69833988
86Amyotrophic lateral sclerosis (HP:0007354)1.69827587
87Pendular nystagmus (HP:0012043)1.69372065
88Vaginal atresia (HP:0000148)1.69000560
89Genital tract atresia (HP:0001827)1.68969680
90Aplasia/Hypoplasia of the uvula (HP:0010293)1.67328037
91Nephronophthisis (HP:0000090)1.66761095
92Clitoromegaly (HP:0000057)1.66594189
93Aplasia/Hypoplasia involving the musculature (HP:0001460)1.65744669
94Hematochezia (HP:0002573)1.65685466
95Iris hypopigmentation (HP:0007730)1.64471132
96Long clavicles (HP:0000890)1.63642283
97Abnormality of T cell number (HP:0011839)1.63201399
98Abnormality of the duodenum (HP:0002246)1.63117470
99Submucous cleft hard palate (HP:0000176)1.62231290
100Inability to walk (HP:0002540)1.61516509

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK34.86424448
2PRKD33.90105518
3ACVR1B3.00143055
4ICK2.68225083
5MAP3K112.67694867
6MAPKAPK32.61833730
7PIM22.54460298
8WNK32.41562357
9MAP3K122.29456049
10CDK122.08686007
11MAP2K42.07362076
12BMPR1B2.03223508
13TESK21.91565568
14MAP2K71.88192683
15MAPK131.82946030
16PRKD21.80230173
17FRK1.78033941
18TXK1.69416983
19BLK1.63067588
20MAP3K51.62690446
21LIMK11.58866262
22MARK21.52710958
23PRKCH1.37835761
24MAP4K11.35327739
25ATR1.31449166
26MAP3K41.28877450
27STK381.23930775
28PINK11.16095271
29DYRK21.14505500
30CSNK1A1L1.14489902
31MAP3K71.07788955
32MARK31.07125805
33MAP3K61.04319177
34CAMK1D1.02518733
35TGFBR11.01551745
36CSNK1G30.97119016
37DYRK30.95152742
38TNK20.94804558
39SIK20.92073193
40SYK0.91586451
41CSNK1G20.91351419
42AKT30.91006205
43KDR0.90387443
44TYRO30.89559824
45IRAK40.88586564
46CAMK40.87457575
47CDK40.87385022
48DYRK1B0.84454040
49PTK2B0.78054292
50TNIK0.77833181
51SIK10.76851616
52CSNK1G10.75919243
53PRKCQ0.74976787
54CLK10.74747088
55PIM10.73737890
56MAPK150.72632545
57PRKCZ0.72363780
58CHUK0.72251673
59CDK60.70501021
60NLK0.66240662
61GRK60.61171904
62PKN10.60199487
63CAMK1G0.59559903
64TRIM280.59023193
65JAK30.58793570
66TESK10.56153595
67PIK3CA0.55759997
68PLK20.55472363
69WNK40.55292049
70YES10.53979441
71ZAP700.53298481
72NEK20.52255676
73DAPK10.50145331
74FGFR20.49332097
75MARK10.48435842
76CSNK1D0.46390685
77PRKAA10.44313607
78PRKCE0.44148548
79SIK30.43518876
80PRKD10.43447915
81AKT10.43230784
82MAPKAPK20.42888480
83BUB10.42373832
84NUAK10.41407535
85RPS6KA50.39620364
86MAP3K10.39332347
87MAP3K100.38518440
88BTK0.36394183
89PIK3CG0.35716090
90PAK60.34599753
91ITK0.34587926
92PRKCG0.32968894
93RPS6KA10.31832879
94LYN0.31073247
95ATM0.29068314
96MELK0.28949210
97TAOK30.28832004
98MAPK110.27347486
99CAMK10.27196961
100RPS6KA60.26293438

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.74440503
2Graft-versus-host disease_Homo sapiens_hsa053323.58983212
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.36705253
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.90103765
5ABC transporters_Homo sapiens_hsa020102.65884717
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.57493462
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.54633739
8Fatty acid biosynthesis_Homo sapiens_hsa000612.37842540
9Homologous recombination_Homo sapiens_hsa034402.34898002
10Fanconi anemia pathway_Homo sapiens_hsa034602.19815042
11Regulation of autophagy_Homo sapiens_hsa041402.10881666
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.10445291
13Lysine degradation_Homo sapiens_hsa003101.88042574
14Selenocompound metabolism_Homo sapiens_hsa004501.84619753
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.73299639
16Antigen processing and presentation_Homo sapiens_hsa046121.72857734
17Primary immunodeficiency_Homo sapiens_hsa053401.63332678
18Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.51378254
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.40800096
20p53 signaling pathway_Homo sapiens_hsa041151.40699718
21Steroid biosynthesis_Homo sapiens_hsa001001.32537757
22Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.32099366
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29436118
24Ether lipid metabolism_Homo sapiens_hsa005651.27019315
25Phototransduction_Homo sapiens_hsa047441.23991407
26Linoleic acid metabolism_Homo sapiens_hsa005911.23172541
27Non-small cell lung cancer_Homo sapiens_hsa052231.21182139
28Measles_Homo sapiens_hsa051621.19499190
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.14528259
30Apoptosis_Homo sapiens_hsa042101.14124248
31Influenza A_Homo sapiens_hsa051641.12206752
32Notch signaling pathway_Homo sapiens_hsa043301.09342276
33Hepatitis B_Homo sapiens_hsa051611.07889570
34Osteoclast differentiation_Homo sapiens_hsa043801.07431767
35Tuberculosis_Homo sapiens_hsa051521.06549523
36Collecting duct acid secretion_Homo sapiens_hsa049661.03555453
37TNF signaling pathway_Homo sapiens_hsa046680.96041978
38Lysosome_Homo sapiens_hsa041420.93017959
39Olfactory transduction_Homo sapiens_hsa047400.89624873
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86698410
41T cell receptor signaling pathway_Homo sapiens_hsa046600.81442936
42Epstein-Barr virus infection_Homo sapiens_hsa051690.81262740
43Sulfur relay system_Homo sapiens_hsa041220.80586965
44Pertussis_Homo sapiens_hsa051330.80378137
45Dopaminergic synapse_Homo sapiens_hsa047280.80375457
46NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78830551
47Fatty acid metabolism_Homo sapiens_hsa012120.78801503
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77971988
49MicroRNAs in cancer_Homo sapiens_hsa052060.77383512
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75621359
51TGF-beta signaling pathway_Homo sapiens_hsa043500.74708709
52Type II diabetes mellitus_Homo sapiens_hsa049300.74562672
53beta-Alanine metabolism_Homo sapiens_hsa004100.72611376
54Herpes simplex infection_Homo sapiens_hsa051680.70288032
55Hepatitis C_Homo sapiens_hsa051600.68407300
56Fructose and mannose metabolism_Homo sapiens_hsa000510.68272127
57Mismatch repair_Homo sapiens_hsa034300.67038958
58Non-homologous end-joining_Homo sapiens_hsa034500.66248147
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63271953
60Morphine addiction_Homo sapiens_hsa050320.63048116
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62028565
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59738248
63Nicotine addiction_Homo sapiens_hsa050330.59610307
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54937346
65Glycerolipid metabolism_Homo sapiens_hsa005610.54556967
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54390796
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.54267010
68Legionellosis_Homo sapiens_hsa051340.53345325
69Arginine and proline metabolism_Homo sapiens_hsa003300.53067511
70Peroxisome_Homo sapiens_hsa041460.50641946
71Ovarian steroidogenesis_Homo sapiens_hsa049130.48414162
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47952443
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46929830
74African trypanosomiasis_Homo sapiens_hsa051430.46779355
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44034363
76Galactose metabolism_Homo sapiens_hsa000520.43558908
77Cocaine addiction_Homo sapiens_hsa050300.43441997
78Calcium signaling pathway_Homo sapiens_hsa040200.42928399
79Viral myocarditis_Homo sapiens_hsa054160.41946312
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41653034
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41191668
82Rheumatoid arthritis_Homo sapiens_hsa053230.40624411
83Proteasome_Homo sapiens_hsa030500.40546928
84mRNA surveillance pathway_Homo sapiens_hsa030150.40517496
85HTLV-I infection_Homo sapiens_hsa051660.40094130
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39214975
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38140440
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37770685
89Malaria_Homo sapiens_hsa051440.37662410
90Melanogenesis_Homo sapiens_hsa049160.36612281
91Tryptophan metabolism_Homo sapiens_hsa003800.35517606
92Hippo signaling pathway_Homo sapiens_hsa043900.34837560
93ErbB signaling pathway_Homo sapiens_hsa040120.34165425
94Fat digestion and absorption_Homo sapiens_hsa049750.34146267
95Taste transduction_Homo sapiens_hsa047420.33376563
96Cell cycle_Homo sapiens_hsa041100.33375404
97MAPK signaling pathway_Homo sapiens_hsa040100.31942244
98Chemokine signaling pathway_Homo sapiens_hsa040620.31486216
99Autoimmune thyroid disease_Homo sapiens_hsa053200.30527708
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30236265

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