YBX1P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cytosolic calcium ion concentration (GO:0051481)8.91226940
2opioid receptor signaling pathway (GO:0038003)8.40023760
3adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)6.96713895
4behavioral response to ethanol (GO:0048149)6.95861836
5negative regulation of cAMP-mediated signaling (GO:0043951)6.89121391
6adult feeding behavior (GO:0008343)6.03641136
7positive regulation of cAMP-mediated signaling (GO:0043950)5.13091191
8ether lipid metabolic process (GO:0046485)5.05319665
9negative regulation of nitric oxide biosynthetic process (GO:0045019)4.64352187
10regulation of translational termination (GO:0006449)4.37113191
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.18239048
12G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.14616707
13energy coupled proton transport, down electrochemical gradient (GO:0015985)4.12706118
14ATP synthesis coupled proton transport (GO:0015986)4.12706118
15protein-cofactor linkage (GO:0018065)4.06082552
16piRNA metabolic process (GO:0034587)3.91798105
17behavioral response to nicotine (GO:0035095)3.79046838
18establishment of protein localization to mitochondrial membrane (GO:0090151)3.76797544
19negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.58775683
20DNA deamination (GO:0045006)3.58327456
21protein complex biogenesis (GO:0070271)3.56506187
22mitochondrial respiratory chain complex assembly (GO:0033108)3.54791517
23cellular response to ammonium ion (GO:0071242)3.48971563
24ncRNA catabolic process (GO:0034661)3.44110398
25DNA replication-dependent nucleosome organization (GO:0034723)3.32427094
26DNA replication-dependent nucleosome assembly (GO:0006335)3.32427094
27cornea development in camera-type eye (GO:0061303)3.29571743
28NADH dehydrogenase complex assembly (GO:0010257)3.26570703
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.26570703
30mitochondrial respiratory chain complex I assembly (GO:0032981)3.26570703
31cell migration in hindbrain (GO:0021535)3.26356953
32positive regulation by host of viral transcription (GO:0043923)3.25497408
33cerebellar Purkinje cell differentiation (GO:0021702)3.21196024
34head development (GO:0060322)3.20966760
35nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.20867344
36positive regulation of fatty acid transport (GO:2000193)3.20050692
37sequestering of actin monomers (GO:0042989)3.17627372
38cellular response to electrical stimulus (GO:0071257)3.10945221
39sensory perception of pain (GO:0019233)3.09104691
40regulation of acrosome reaction (GO:0060046)3.08866068
41spinal cord association neuron differentiation (GO:0021527)3.08253754
42mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.07300635
43glycerol ether metabolic process (GO:0006662)3.06736736
44electron transport chain (GO:0022900)3.05425916
45respiratory electron transport chain (GO:0022904)3.05303743
46maturation of SSU-rRNA (GO:0030490)3.04648591
47neuronal action potential (GO:0019228)3.04221763
48cellular ketone body metabolic process (GO:0046950)3.02061038
49positive regulation of icosanoid secretion (GO:0032305)2.97393168
50regulation of glutamate receptor signaling pathway (GO:1900449)2.95932730
51nephron epithelium morphogenesis (GO:0072088)2.92863402
52nephron tubule morphogenesis (GO:0072078)2.92863402
53regulation of cAMP-mediated signaling (GO:0043949)2.90777256
54ribonucleoprotein complex disassembly (GO:0032988)2.89546807
55RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.88825624
56tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.88825624
57ether metabolic process (GO:0018904)2.87262835
58protein neddylation (GO:0045116)2.85244400
59detection of light stimulus involved in visual perception (GO:0050908)2.85066814
60detection of light stimulus involved in sensory perception (GO:0050962)2.85066814
61detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.83914739
62translational termination (GO:0006415)2.82073420
63meiotic cell cycle (GO:0051321)2.80993565
64viral transcription (GO:0019083)2.79808212
65regulation of protein glycosylation (GO:0060049)2.77139725
66regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.74333587
67protein localization to synapse (GO:0035418)2.70815045
68coenzyme catabolic process (GO:0009109)2.70628281
69fat-soluble vitamin catabolic process (GO:0042363)2.70560785
70vitamin catabolic process (GO:0009111)2.70560785
71somite rostral/caudal axis specification (GO:0032525)2.70125316
72negative regulation of adenylate cyclase activity (GO:0007194)2.70080159
73positive regulation of gastrulation (GO:2000543)2.69551717
74replication fork processing (GO:0031297)2.67986881
75cellular response to alkaloid (GO:0071312)2.66537742
76negative regulation of lyase activity (GO:0051350)2.65927714
77ketone body metabolic process (GO:1902224)2.64460015
78positive regulation of prostaglandin secretion (GO:0032308)2.63694335
79indolalkylamine metabolic process (GO:0006586)2.62193542
80endoderm formation (GO:0001706)2.61692478
81kynurenine metabolic process (GO:0070189)2.61479891
82regulation of action potential (GO:0098900)2.60493845
83translational elongation (GO:0006414)2.59906228
84regulation of glycogen (starch) synthase activity (GO:2000465)2.59619338
85cell differentiation in spinal cord (GO:0021515)2.59310860
86membrane depolarization during action potential (GO:0086010)2.59288598
87thyroid hormone generation (GO:0006590)2.58653317
88negative regulation of cyclase activity (GO:0031280)2.57719127
89GTP biosynthetic process (GO:0006183)2.55427541
90base-excision repair, AP site formation (GO:0006285)2.55376241
91N-glycan processing (GO:0006491)2.53262363
92quinone biosynthetic process (GO:1901663)2.52385077
93positive regulation of guanylate cyclase activity (GO:0031284)2.50627069
94DNA double-strand break processing (GO:0000729)2.50536607
95notochord development (GO:0030903)2.50500093
96resolution of meiotic recombination intermediates (GO:0000712)2.49840242
97mannosylation (GO:0097502)2.49749874
98regulation of rhodopsin mediated signaling pathway (GO:0022400)2.48406328
99dopamine receptor signaling pathway (GO:0007212)2.48406115
100chaperone-mediated protein transport (GO:0072321)2.47501653

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.48762110
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.52188533
3VDR_22108803_ChIP-Seq_LS180_Human3.43100449
4ZNF274_21170338_ChIP-Seq_K562_Hela3.36579600
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.70251542
6TAF15_26573619_Chip-Seq_HEK293_Human2.66470739
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.54019574
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.51526701
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.17676256
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.17627848
11GBX2_23144817_ChIP-Seq_PC3_Human2.03627259
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.96933131
13BMI1_23680149_ChIP-Seq_NPCS_Mouse1.92690822
14CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82725852
15CBX2_27304074_Chip-Seq_ESCs_Mouse1.76919435
16EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.75294459
17NOTCH1_21737748_ChIP-Seq_TLL_Human1.72985993
18TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71943200
19POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.71943200
20JARID2_20064375_ChIP-Seq_MESCs_Mouse1.67409879
21TP53_22573176_ChIP-Seq_HFKS_Human1.67349402
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67252210
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.61477588
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61407676
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.59487794
26HTT_18923047_ChIP-ChIP_STHdh_Human1.55461230
27REST_21632747_ChIP-Seq_MESCs_Mouse1.55104456
28GATA3_21878914_ChIP-Seq_MCF-7_Human1.55028245
29TP63_19390658_ChIP-ChIP_HaCaT_Human1.54915380
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.53982715
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53854002
32RNF2_27304074_Chip-Seq_NSC_Mouse1.52556505
33NANOG_20526341_ChIP-Seq_ESCs_Human1.51830325
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.46682311
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.44771628
36EWS_26573619_Chip-Seq_HEK293_Human1.44470535
37FUS_26573619_Chip-Seq_HEK293_Human1.43786588
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43645787
39ERA_21632823_ChIP-Seq_H3396_Human1.42159552
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.41028018
41BCAT_22108803_ChIP-Seq_LS180_Human1.39103708
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38839095
43CBP_20019798_ChIP-Seq_JUKART_Human1.38839095
44ETV2_25802403_ChIP-Seq_MESCs_Mouse1.35884089
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.35208745
46REST_18959480_ChIP-ChIP_MESCs_Mouse1.32981889
47SOX2_19829295_ChIP-Seq_ESCs_Human1.32711609
48NANOG_19829295_ChIP-Seq_ESCs_Human1.32711609
49ER_23166858_ChIP-Seq_MCF-7_Human1.32250925
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31592832
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.29469759
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27166988
53CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25245489
54RXR_22108803_ChIP-Seq_LS180_Human1.24369121
55MYC_18940864_ChIP-ChIP_HL60_Human1.22266300
56GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21777640
57JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21666659
58IGF1R_20145208_ChIP-Seq_DFB_Human1.20451941
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.19188669
60SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.19016436
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.18776769
62SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18561461
63VDR_23849224_ChIP-Seq_CD4+_Human1.16747606
64NCOR_22424771_ChIP-Seq_293T_Human1.16626807
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16488682
66P300_19829295_ChIP-Seq_ESCs_Human1.16179509
67SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.16092948
68FOXA1_25329375_ChIP-Seq_VCAP_Human1.15478608
69FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15478608
70IRF1_19129219_ChIP-ChIP_H3396_Human1.12946594
71EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.10912101
72RAC3_21632823_ChIP-Seq_H3396_Human1.09776957
73KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09098656
74RNF2_27304074_Chip-Seq_ESCs_Mouse1.08485077
75TDRD3_21172665_ChIP-Seq_MCF-7_Human1.07338127
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04662664
77SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04259789
78OCT4_20526341_ChIP-Seq_ESCs_Human1.03206628
79YY1_22570637_ChIP-Seq_MALME-3M_Human1.02776549
80TAF2_19829295_ChIP-Seq_ESCs_Human1.02472633
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02441807
82PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01840755
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01095176
84TCF4_23295773_ChIP-Seq_U87_Human0.99968653
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99247318
86STAT3_23295773_ChIP-Seq_U87_Human0.99079652
87RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97616900
88SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96966317
89FOXH1_21741376_ChIP-Seq_ESCs_Human0.96765815
90RUNX2_22187159_ChIP-Seq_PCA_Human0.96271899
91SMAD3_21741376_ChIP-Seq_EPCs_Human0.95487084
92SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95259154
93FOXH1_21741376_ChIP-Seq_EPCs_Human0.94575859
94RNF2_18974828_ChIP-Seq_MESCs_Mouse0.93233779
95EZH2_18974828_ChIP-Seq_MESCs_Mouse0.93233779
96RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.93016246
97DROSHA_22980978_ChIP-Seq_HELA_Human0.90569089
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89769709
99NFE2_27457419_Chip-Seq_LIVER_Mouse0.89269161
100RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88286661

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001968_abnormal_touch/_nociception4.14885778
2MP0002876_abnormal_thyroid_physiology3.22348335
3MP0009278_abnormal_bone_marrow2.88476961
4MP0003880_abnormal_central_pattern2.71739337
5MP0000569_abnormal_digit_pigmentation2.42061173
6MP0001501_abnormal_sleep_pattern2.38259948
7MP0005645_abnormal_hypothalamus_physiol2.34979468
8MP0009046_muscle_twitch2.34408274
9MP0005646_abnormal_pituitary_gland2.31481435
10MP0002272_abnormal_nervous_system2.19282683
11MP0005551_abnormal_eye_electrophysiolog2.17183327
12MP0001485_abnormal_pinna_reflex2.12559099
13MP0000566_synostosis2.04779151
14MP0002736_abnormal_nociception_after2.02129855
15MP0005360_urolithiasis1.99127741
16MP0003890_abnormal_embryonic-extraembry1.98102499
17MP0009745_abnormal_behavioral_response1.95308160
18MP0002653_abnormal_ependyma_morphology1.91982376
19MP0002733_abnormal_thermal_nociception1.88831295
20MP0010386_abnormal_urinary_bladder1.88508143
21MP0003283_abnormal_digestive_organ1.87113847
22MP0003122_maternal_imprinting1.83728426
23MP0003195_calcinosis1.83694225
24MP0009379_abnormal_foot_pigmentation1.83519217
25MP0004885_abnormal_endolymph1.82283173
26MP0003136_yellow_coat_color1.79159797
27MP0002557_abnormal_social/conspecific_i1.73295205
28MP0001664_abnormal_digestion1.70140372
29MP0008872_abnormal_physiological_respon1.69012822
30MP0009780_abnormal_chondrocyte_physiolo1.66987770
31MP0006292_abnormal_olfactory_placode1.65003553
32MP0001529_abnormal_vocalization1.64444428
33MP0003635_abnormal_synaptic_transmissio1.59848372
34MP0003787_abnormal_imprinting1.57819897
35MP0001970_abnormal_pain_threshold1.57045344
36MP0005386_behavior/neurological_phenoty1.56057134
37MP0004924_abnormal_behavior1.56057134
38MP0003252_abnormal_bile_duct1.52576100
39MP0004142_abnormal_muscle_tone1.52262737
40MP0003121_genomic_imprinting1.51136320
41MP0002063_abnormal_learning/memory/cond1.49739604
42MP0009764_decreased_sensitivity_to1.44863610
43MP0006035_abnormal_mitochondrial_morpho1.43055853
44MP0002572_abnormal_emotion/affect_behav1.39868736
45MP0008875_abnormal_xenobiotic_pharmacok1.39155829
46MP0003959_abnormal_lean_body1.38398207
47MP0002067_abnormal_sensory_capabilities1.36754459
48MP0004147_increased_porphyrin_level1.34029316
49MP0000778_abnormal_nervous_system1.32865212
50MP0006276_abnormal_autonomic_nervous1.32405044
51MP0005503_abnormal_tendon_morphology1.31185869
52MP0002735_abnormal_chemical_nociception1.30796745
53MP0001486_abnormal_startle_reflex1.28110470
54MP0000538_abnormal_urinary_bladder1.27653290
55MP0002064_seizures1.26532955
56MP0004133_heterotaxia1.26507414
57MP0005084_abnormal_gallbladder_morpholo1.25872026
58MP0005085_abnormal_gallbladder_physiolo1.20567981
59MP0003646_muscle_fatigue1.17677096
60MP0002693_abnormal_pancreas_physiology1.12489541
61MP0004742_abnormal_vestibular_system1.10704776
62MP0002938_white_spotting1.10444262
63MP0004859_abnormal_synaptic_plasticity1.09516435
64MP0005195_abnormal_posterior_eye1.08071486
65MP0002638_abnormal_pupillary_reflex1.07872351
66MP0009333_abnormal_splenocyte_physiolog1.06748947
67MP0000049_abnormal_middle_ear1.06164414
68MP0001919_abnormal_reproductive_system1.05560199
69MP0002909_abnormal_adrenal_gland1.04995216
70MP0003633_abnormal_nervous_system1.03394725
71MP0005389_reproductive_system_phenotype1.03331633
72MP0003567_abnormal_fetal_cardiomyocyte1.03152454
73MP0002160_abnormal_reproductive_system1.02737754
74MP0000955_abnormal_spinal_cord0.99055992
75MP0002277_abnormal_respiratory_mucosa0.98520381
76MP0005670_abnormal_white_adipose0.97918051
77MP0005310_abnormal_salivary_gland0.94862527
78MP0001963_abnormal_hearing_physiology0.94490318
79MP0002752_abnormal_somatic_nervous0.93529810
80MP0001986_abnormal_taste_sensitivity0.92988681
81MP0000631_abnormal_neuroendocrine_gland0.92970385
82MP0001984_abnormal_olfaction0.91556151
83MP0008877_abnormal_DNA_methylation0.89941579
84MP0003937_abnormal_limbs/digits/tail_de0.89662466
85MP0001188_hyperpigmentation0.88814321
86MP0006072_abnormal_retinal_apoptosis0.88636026
87MP0002229_neurodegeneration0.88326555
88MP0002102_abnormal_ear_morphology0.87916520
89MP0001440_abnormal_grooming_behavior0.85731101
90MP0003638_abnormal_response/metabolism_0.85324306
91MP0003119_abnormal_digestive_system0.84492685
92MP0005174_abnormal_tail_pigmentation0.84474377
93MP0004858_abnormal_nervous_system0.84284517
94MP0008789_abnormal_olfactory_epithelium0.82564866
95MP0000678_abnormal_parathyroid_gland0.81543943
96MP0002734_abnormal_mechanical_nocicepti0.80904261
97MP0002882_abnormal_neuron_morphology0.80246296
98MP0002928_abnormal_bile_duct0.78553333
99MP0000230_abnormal_systemic_arterial0.75781917
100MP0000026_abnormal_inner_ear0.75463490

Predicted human phenotypes

RankGene SetZ-score
1Thyroid-stimulating hormone excess (HP:0002925)7.34151034
2Volvulus (HP:0002580)5.62783342
3Type II lissencephaly (HP:0007260)3.83374338
4Agitation (HP:0000713)3.57658664
5Focal motor seizures (HP:0011153)3.47317648
6Dysdiadochokinesis (HP:0002075)3.46183863
7Abnormality of the aortic arch (HP:0012303)3.35347195
8Congenital stationary night blindness (HP:0007642)3.21748227
9Large for gestational age (HP:0001520)3.14974553
10Acute necrotizing encephalopathy (HP:0006965)3.08531379
11Genetic anticipation (HP:0003743)3.08140191
12Tubular atrophy (HP:0000092)3.06360274
13Lissencephaly (HP:0001339)3.04047066
14Abnormal mitochondria in muscle tissue (HP:0008316)2.99853651
15Abnormality of midbrain morphology (HP:0002418)2.97482283
16Molar tooth sign on MRI (HP:0002419)2.97482283
17Pendular nystagmus (HP:0012043)2.96754459
18Abnormality of the ileum (HP:0001549)2.91564353
19Rib fusion (HP:0000902)2.80471344
20Mesangial abnormality (HP:0001966)2.79318587
21Gaze-evoked nystagmus (HP:0000640)2.73308364
22Cerebellar dysplasia (HP:0007033)2.69993979
23Nephronophthisis (HP:0000090)2.66832737
24Acute encephalopathy (HP:0006846)2.66046887
25Atonic seizures (HP:0010819)2.64981635
26Progressive inability to walk (HP:0002505)2.64848167
27Intestinal atresia (HP:0011100)2.63798586
28Dialeptic seizures (HP:0011146)2.57486592
29Hypoplasia of the brainstem (HP:0002365)2.53026292
30Aplasia/Hypoplasia of the brainstem (HP:0007362)2.53026292
31Supernumerary spleens (HP:0009799)2.52792894
32Broad alveolar ridges (HP:0000187)2.49237400
33Epileptic encephalopathy (HP:0200134)2.45493399
34Pancreatic fibrosis (HP:0100732)2.43878652
35Pancreatic cysts (HP:0001737)2.42180913
36Mitochondrial inheritance (HP:0001427)2.38914481
37Increased CSF lactate (HP:0002490)2.34147629
38Hypoplasia of the pons (HP:0012110)2.33070042
39Optic nerve hypoplasia (HP:0000609)2.31991309
40Focal seizures (HP:0007359)2.31028863
41Pancreatic islet-cell hyperplasia (HP:0004510)2.30822415
42True hermaphroditism (HP:0010459)2.30472734
43Shawl scrotum (HP:0000049)2.29811733
44Reticulocytopenia (HP:0001896)2.29480927
453-Methylglutaconic aciduria (HP:0003535)2.27809967
46Microretrognathia (HP:0000308)2.27381873
47Inability to walk (HP:0002540)2.27042648
48Absent thumb (HP:0009777)2.26708311
49Progressive macrocephaly (HP:0004481)2.24610516
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.23973777
51Absence seizures (HP:0002121)2.23803012
52Birth length less than 3rd percentile (HP:0003561)2.23677461
53Aplasia/Hypoplasia of the spleen (HP:0010451)2.21380887
54Lipid accumulation in hepatocytes (HP:0006561)2.19802739
55Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.18988353
56Asplenia (HP:0001746)2.17664440
57Pachygyria (HP:0001302)2.15178109
58Oligodontia (HP:0000677)2.14963348
59Optic disc pallor (HP:0000543)2.14447424
60Limb dystonia (HP:0002451)2.14146684
61Renal cortical cysts (HP:0000803)2.12384973
62Large eyes (HP:0001090)2.11861443
63Breast hypoplasia (HP:0003187)2.11263064
64Status epilepticus (HP:0002133)2.11083195
65Generalized tonic-clonic seizures (HP:0002069)2.10487118
66Abnormality of the pons (HP:0007361)2.09438553
67Severe muscular hypotonia (HP:0006829)2.05435784
68Chronic bronchitis (HP:0004469)2.05000350
69Abnormality of the renal medulla (HP:0100957)2.04741024
70Attenuation of retinal blood vessels (HP:0007843)2.01997107
71Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.01901184
72Abnormality of cells of the erythroid lineage (HP:0012130)2.01314250
73Abnormal rod and cone electroretinograms (HP:0008323)2.00695467
74Abnormality of the renal cortex (HP:0011035)2.00276015
75Progressive cerebellar ataxia (HP:0002073)1.98058866
76Abnormal biliary tract physiology (HP:0012439)1.97609512
77Bile duct proliferation (HP:0001408)1.97609512
78Increased hepatocellular lipid droplets (HP:0006565)1.97013028
79Increased corneal curvature (HP:0100692)1.95895860
80Keratoconus (HP:0000563)1.95895860
81Broad-based gait (HP:0002136)1.93206494
82Aplastic anemia (HP:0001915)1.92364675
83Meckel diverticulum (HP:0002245)1.92359177
84Polydipsia (HP:0001959)1.90932579
85Abnormal drinking behavior (HP:0030082)1.90932579
86Cerebral edema (HP:0002181)1.90925210
87Hypoproteinemia (HP:0003075)1.89993448
88Chronic hepatic failure (HP:0100626)1.89700468
89Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87720070
90Poor head control (HP:0002421)1.87255828
91Hydroureter (HP:0000072)1.87014164
92Medial flaring of the eyebrow (HP:0010747)1.84534641
93Abnormality of the labia minora (HP:0012880)1.82669863
94Increased serum lactate (HP:0002151)1.79245156
95Horseshoe kidney (HP:0000085)1.78493493
96Horizontal nystagmus (HP:0000666)1.78331384
97Hypoplasia of the radius (HP:0002984)1.77212198
98Decreased central vision (HP:0007663)1.77083784
99Congenital ichthyosiform erythroderma (HP:0007431)1.76503016
100Patellar aplasia (HP:0006443)1.75016429

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK28.42876314
2WNK43.42836185
3PINK13.34929750
4MAP4K22.78683913
5PNCK2.44714448
6ADRBK12.28405316
7PRKCG2.24035970
8FRK2.16494668
9GRK12.03987147
10STK392.02338341
11MARK11.84458555
12DYRK31.83244246
13BCKDK1.77260728
14BMPR1B1.69188798
15MAPK131.56996562
16TYRO31.50396857
17ZAK1.49364275
18DYRK21.48179300
19CAMKK21.47008130
20OXSR11.46336587
21CASK1.39025224
22MKNK21.38022934
23WNK31.33486444
24PRKCE1.32796554
25TNIK1.29361318
26TSSK61.29122141
27ACVR1B1.25561784
28NME11.15337221
29TGFBR11.13059860
30TESK21.13046046
31VRK21.04756941
32NEK11.03298256
33WNK11.00917986
34CAMK2A1.00709587
35TAF10.99064090
36MAP2K70.97181705
37MAP3K40.96582428
38VRK10.90482670
39CAMK1D0.89777846
40MKNK10.86161971
41CLK10.83719586
42CAMK10.81817520
43NEK20.81092395
44NUAK10.80133434
45ERN10.79110075
46NTRK20.78855221
47TRIM280.78549557
48CSNK1E0.76754705
49WEE10.76673288
50CAMK1G0.75378581
51MAPKAPK50.74877951
52TLK10.70440223
53PRKCI0.69302619
54LIMK10.68246011
55CAMKK10.66740970
56KDR0.65054925
57CSNK2A20.64526968
58CSNK1G20.62113186
59PRKCH0.57711232
60MAP2K60.54510254
61TXK0.53235667
62MINK10.52468207
63DYRK1A0.51937567
64TAOK30.51364364
65CAMK40.50856872
66GRK50.49887292
67PHKG20.48623423
68PHKG10.48623423
69CDC70.48422757
70PRKCB0.47840028
71EIF2AK30.47534014
72SGK10.47040892
73PRKACA0.46599204
74PRKCZ0.46026041
75PRKCA0.45904066
76INSRR0.44878502
77ERBB20.44235124
78PKN10.43719812
79BRSK10.43608407
80PRKCQ0.43525307
81MUSK0.42959750
82ATR0.40990852
83CSNK2A10.39903341
84SIK20.39804620
85MAPK150.39787934
86MAP2K40.39512405
87PIK3CA0.38424928
88CSNK1A10.38418332
89AURKB0.35343878
90PLK20.34106377
91STK160.31729527
92RPS6KA50.31506294
93ABL20.30432373
94PLK10.29235475
95AURKA0.29098862
96TIE10.28751875
97PRKACB0.28059976
98EIF2AK20.27680696
99STK110.27424700
100RPS6KA30.26825272

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.17370303
2Ribosome_Homo sapiens_hsa030103.14735477
3Parkinsons disease_Homo sapiens_hsa050123.04076534
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.63738780
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.58914750
6Nicotine addiction_Homo sapiens_hsa050332.46664130
7Phototransduction_Homo sapiens_hsa047442.43908695
8Protein export_Homo sapiens_hsa030602.33452285
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.27196487
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.22007292
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.14588888
12Huntingtons disease_Homo sapiens_hsa050162.12527501
13Cardiac muscle contraction_Homo sapiens_hsa042602.08976413
14RNA polymerase_Homo sapiens_hsa030202.05597977
15Linoleic acid metabolism_Homo sapiens_hsa005912.05060809
16Alzheimers disease_Homo sapiens_hsa050101.99668169
17Basal transcription factors_Homo sapiens_hsa030221.99591243
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.99034507
19Sulfur relay system_Homo sapiens_hsa041221.98072456
20Proteasome_Homo sapiens_hsa030501.95765032
21Butanoate metabolism_Homo sapiens_hsa006501.93632133
22Olfactory transduction_Homo sapiens_hsa047401.89627200
23Taste transduction_Homo sapiens_hsa047421.84816874
24Morphine addiction_Homo sapiens_hsa050321.77338622
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.65835756
26Fanconi anemia pathway_Homo sapiens_hsa034601.63253859
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.62753528
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.59048485
29Dorso-ventral axis formation_Homo sapiens_hsa043201.56907644
30Homologous recombination_Homo sapiens_hsa034401.55216753
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.34267371
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.28858279
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23009498
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.21464542
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18369886
36Pyrimidine metabolism_Homo sapiens_hsa002401.15582424
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.15369747
38ABC transporters_Homo sapiens_hsa020101.13273668
39Propanoate metabolism_Homo sapiens_hsa006401.04279440
40Ether lipid metabolism_Homo sapiens_hsa005651.02501434
41Selenocompound metabolism_Homo sapiens_hsa004501.01608082
42RNA degradation_Homo sapiens_hsa030181.01519776
43Nitrogen metabolism_Homo sapiens_hsa009101.00956852
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00641961
45Tryptophan metabolism_Homo sapiens_hsa003800.96238759
46Arachidonic acid metabolism_Homo sapiens_hsa005900.95212242
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.92816252
48Caffeine metabolism_Homo sapiens_hsa002320.86576325
49One carbon pool by folate_Homo sapiens_hsa006700.84437965
50Retinol metabolism_Homo sapiens_hsa008300.82705088
51Peroxisome_Homo sapiens_hsa041460.81692231
52Glutamatergic synapse_Homo sapiens_hsa047240.81488453
53Sulfur metabolism_Homo sapiens_hsa009200.79817674
54Asthma_Homo sapiens_hsa053100.78956461
55Fat digestion and absorption_Homo sapiens_hsa049750.78237281
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75410158
57Calcium signaling pathway_Homo sapiens_hsa040200.73843346
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73617868
59Insulin secretion_Homo sapiens_hsa049110.73574732
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72235625
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71647562
62GABAergic synapse_Homo sapiens_hsa047270.71468589
63Purine metabolism_Homo sapiens_hsa002300.70434770
64Metabolic pathways_Homo sapiens_hsa011000.69762367
65Chemical carcinogenesis_Homo sapiens_hsa052040.68738369
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65820952
67Salivary secretion_Homo sapiens_hsa049700.61695013
68Long-term depression_Homo sapiens_hsa047300.58097415
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57829114
70Base excision repair_Homo sapiens_hsa034100.57342567
71Glycerolipid metabolism_Homo sapiens_hsa005610.56447184
72Glutathione metabolism_Homo sapiens_hsa004800.55490983
73RNA transport_Homo sapiens_hsa030130.55394055
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53196361
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.51896552
76Ovarian steroidogenesis_Homo sapiens_hsa049130.49845414
77Steroid biosynthesis_Homo sapiens_hsa001000.49490259
78Starch and sucrose metabolism_Homo sapiens_hsa005000.47846624
79DNA replication_Homo sapiens_hsa030300.44800840
80Hedgehog signaling pathway_Homo sapiens_hsa043400.44162221
81Allograft rejection_Homo sapiens_hsa053300.42400379
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.40809766
83Primary immunodeficiency_Homo sapiens_hsa053400.40476507
84Autoimmune thyroid disease_Homo sapiens_hsa053200.40200520
85Pancreatic secretion_Homo sapiens_hsa049720.40113833
86Basal cell carcinoma_Homo sapiens_hsa052170.38914250
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38652558
88Mineral absorption_Homo sapiens_hsa049780.38081164
89Sphingolipid metabolism_Homo sapiens_hsa006000.34837872
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34488123
91Serotonergic synapse_Homo sapiens_hsa047260.34257339
92Dopaminergic synapse_Homo sapiens_hsa047280.33519321
93Spliceosome_Homo sapiens_hsa030400.33030027
94Estrogen signaling pathway_Homo sapiens_hsa049150.30358759
95Fatty acid degradation_Homo sapiens_hsa000710.29184362
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.26150311
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.25950078
98Nucleotide excision repair_Homo sapiens_hsa034200.24667400
99Graft-versus-host disease_Homo sapiens_hsa053320.24612376
100Vitamin digestion and absorption_Homo sapiens_hsa049770.23237387

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