YBX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nucleic acid binding protein which is highly expressed in germ cells. The encoded protein binds to a Y-box element in the promoters of certain genes but also binds to mRNA transcribed from these genes. Pseudogenes for this gene are located on chromosome 10 and 15. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1binding of sperm to zona pellucida (GO:0007339)9.88940967
2cell-cell recognition (GO:0009988)9.57091060
3plasma membrane fusion (GO:0045026)9.52510296
4epithelial cilium movement (GO:0003351)9.37122815
5cell wall macromolecule metabolic process (GO:0044036)9.33841199
6cell wall macromolecule catabolic process (GO:0016998)9.33841199
7motile cilium assembly (GO:0044458)9.23861037
8* spermatid development (GO:0007286)9.22120655
9male meiosis (GO:0007140)8.79460146
10regulation of cilium movement (GO:0003352)8.74797301
11reproduction (GO:0000003)8.61592107
12synaptonemal complex organization (GO:0070193)8.44355079
13synaptonemal complex assembly (GO:0007130)8.05053662
14cilium movement (GO:0003341)7.79774698
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.62742341
16single fertilization (GO:0007338)7.21111250
17negative regulation of inclusion body assembly (GO:0090084)7.18811723
18sperm capacitation (GO:0048240)6.75845557
19male meiosis I (GO:0007141)6.47833660
20* spermatogenesis (GO:0007283)6.44560201
21* male gamete generation (GO:0048232)6.42367277
22DNA methylation involved in gamete generation (GO:0043046)6.41361661
23fertilization (GO:0009566)6.39890946
24* gamete generation (GO:0007276)5.93082698
25microtubule depolymerization (GO:0007019)5.89277269
26regulation of inclusion body assembly (GO:0090083)5.82010368
27organic cation transport (GO:0015695)5.74338700
28chromosome organization involved in meiosis (GO:0070192)5.53915695
29* germ cell development (GO:0007281)5.37739214
30meiotic nuclear division (GO:0007126)5.34450346
31* cellular process involved in reproduction in multicellular organism (GO:0022412)5.30242356
32meiosis I (GO:0007127)5.27345698
33regulation of microtubule-based movement (GO:0060632)5.21159217
34ventricular system development (GO:0021591)5.02348222
35calcium ion-dependent exocytosis (GO:0017156)4.91134657
36seminiferous tubule development (GO:0072520)4.89439626
37chromosome condensation (GO:0030261)4.68605234
38* multicellular organismal reproductive process (GO:0048609)4.67211265
39microtubule severing (GO:0051013)4.62566923
40left/right pattern formation (GO:0060972)4.58899478
41meiotic cell cycle (GO:0051321)4.56456962
42cell recognition (GO:0008037)4.54932696
43DNA packaging (GO:0006323)4.50101190
44regulation of acrosome reaction (GO:0060046)4.49582124
45glycerol ether metabolic process (GO:0006662)4.22061535
46regulation of histone H3-K9 methylation (GO:0051570)4.16887105
47paraxial mesoderm development (GO:0048339)4.16564861
48negative regulation of histone methylation (GO:0031061)4.10837287
49genitalia morphogenesis (GO:0035112)3.94539207
50regulation of meiosis I (GO:0060631)3.94534769
51gene silencing by RNA (GO:0031047)3.92161036
52mitotic chromosome condensation (GO:0007076)3.92149037
53protein-DNA complex disassembly (GO:0032986)3.89554204
54nucleosome disassembly (GO:0006337)3.89554204
55chaperone-mediated protein complex assembly (GO:0051131)3.89358118
56ether metabolic process (GO:0018904)3.88971609
57spermatid nucleus differentiation (GO:0007289)3.78378882
58multicellular organismal development (GO:0007275)3.78121541
59planar cell polarity pathway involved in neural tube closure (GO:0090179)3.74477791
60regulation of female gonad development (GO:2000194)3.72720496
61negative regulation of gene silencing (GO:0060969)3.70460959
62monoubiquitinated protein deubiquitination (GO:0035520)3.70154851
63protein polyglutamylation (GO:0018095)3.68244897
64protein localization to cilium (GO:0061512)3.60958621
65meiotic cell cycle process (GO:1903046)3.60688462
66NADH metabolic process (GO:0006734)3.54745703
67protein kinase C signaling (GO:0070528)3.54498936
68bundle of His cell to Purkinje myocyte communication (GO:0086069)3.54039738
69mitotic sister chromatid cohesion (GO:0007064)3.50212061
70regulation of spindle checkpoint (GO:0090231)3.44054059
71regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.42813216
72carnitine transport (GO:0015879)3.41347408
73amino-acid betaine transport (GO:0015838)3.41347408
74protein refolding (GO:0042026)3.41174964
75histone H3-K36 demethylation (GO:0070544)3.37198758
76positive regulation of Cdc42 GTPase activity (GO:0043089)3.34392378
77positive regulation of gene expression, epigenetic (GO:0045815)3.33633825
78regulation of gene silencing by RNA (GO:0060966)3.33585571
79regulation of posttranscriptional gene silencing (GO:0060147)3.33585571
80regulation of gene silencing by miRNA (GO:0060964)3.33585571
81regulation of DNA methylation (GO:0044030)3.31625434
82carnitine transmembrane transport (GO:1902603)3.31380050
83proline biosynthetic process (GO:0006561)3.27393318
84regulation of chromatin silencing (GO:0031935)3.23777770
85single strand break repair (GO:0000012)3.21914236
86citrulline biosynthetic process (GO:0019240)3.20787964
87protein localization to chromosome, centromeric region (GO:0071459)3.20526320
88protein localization to kinetochore (GO:0034501)3.20412531
89synapsis (GO:0007129)3.20000948
90histone H3-K9 demethylation (GO:0033169)3.17565997
91regulation of chromatin binding (GO:0035561)3.16058940
92heterochromatin organization (GO:0070828)3.15466204
93establishment of apical/basal cell polarity (GO:0035089)3.14619629
94epithelial cell-cell adhesion (GO:0090136)3.13444593
95nucleus organization (GO:0006997)3.13383571
96negative regulation of organelle assembly (GO:1902116)3.13322905
97phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.12194190
98regulation of guanylate cyclase activity (GO:0031282)3.11734840
99glycolytic process (GO:0006096)3.10106695
100gene silencing (GO:0016458)3.07927090
101intraciliary transport (GO:0042073)3.04643027
102microtubule polymerization or depolymerization (GO:0031109)3.03667714
103establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.03554173
104L-alpha-amino acid transmembrane transport (GO:1902475)3.01066799
105cell-cell junction maintenance (GO:0045217)3.01018656
106axoneme assembly (GO:0035082)2.99275462
107establishment or maintenance of bipolar cell polarity (GO:0061245)2.98365803
108establishment or maintenance of apical/basal cell polarity (GO:0035088)2.98365803
109protein complex localization (GO:0031503)2.97791605
110nuclear pore complex assembly (GO:0051292)2.91692073
111intracellular estrogen receptor signaling pathway (GO:0030520)2.90644589
112lactate metabolic process (GO:0006089)2.90437762
113desmosome organization (GO:0002934)2.90222808
114microtubule-based movement (GO:0007018)2.89028326
115citrulline metabolic process (GO:0000052)2.87274740
116regulation of bile acid biosynthetic process (GO:0070857)2.85683538
117regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.84261168
118interferon-gamma secretion (GO:0072643)2.82212156
119* oocyte development (GO:0048599)2.81145451
120cilium organization (GO:0044782)2.79717618
121negative regulation of skeletal muscle tissue development (GO:0048642)2.79240207
122sexual reproduction (GO:0019953)2.78755121
123convergent extension (GO:0060026)2.78615476
124histone lysine demethylation (GO:0070076)2.78165429
125polyol catabolic process (GO:0046174)2.77952673
126positive regulation of chromosome segregation (GO:0051984)2.77090685
127trophectodermal cell differentiation (GO:0001829)2.74628550
128RNA localization (GO:0006403)2.74195550
129regulation of centriole replication (GO:0046599)2.72993686
130nucleoside diphosphate phosphorylation (GO:0006165)2.71447557
131sex differentiation (GO:0007548)2.70716274
132regulation of gene silencing (GO:0060968)2.68755772
133alditol metabolic process (GO:0019400)2.68089030
134DNA unwinding involved in DNA replication (GO:0006268)2.67639593
135cilium morphogenesis (GO:0060271)2.64930949
136cilium assembly (GO:0042384)2.64818885
137pre-miRNA processing (GO:0031054)2.64487385
138DNA methylation (GO:0006306)2.63687893
139DNA alkylation (GO:0006305)2.63687893
140intestinal absorption (GO:0050892)2.63091741
141regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.60523980
142cellular component assembly involved in morphogenesis (GO:0010927)2.60381715
143RNA destabilization (GO:0050779)2.59519661
144regulation of cilium assembly (GO:1902017)2.59238915
145proline metabolic process (GO:0006560)2.58446908
146response to food (GO:0032094)2.58446651
147peptidyl-lysine dimethylation (GO:0018027)2.58238750
148regulation of histone H3-K4 methylation (GO:0051569)2.56007341
149peptidyl-glutamic acid modification (GO:0018200)2.55187585
150histone demethylation (GO:0016577)2.55144184
151regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.55051846
152positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.52762676
153histone arginine methylation (GO:0034969)2.51684687
154receptor recycling (GO:0001881)2.51361646
155notochord development (GO:0030903)2.50647724
156intestinal epithelial cell development (GO:0060576)2.49922066
157establishment or maintenance of monopolar cell polarity (GO:0061339)2.49646359
158establishment of monopolar cell polarity (GO:0061162)2.49646359
159regulation of histone methylation (GO:0031060)2.49389525
160homocysteine metabolic process (GO:0050667)2.47464505
161chromatin silencing (GO:0006342)2.46241064
162cell junction maintenance (GO:0034331)2.46005150
163regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.44957362
164DNA conformation change (GO:0071103)2.44834600
165calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.41682552
166regulation of stem cell maintenance (GO:2000036)2.40240457
167sperm motility (GO:0030317)13.0032919
168fusion of sperm to egg plasma membrane (GO:0007342)12.5413816
169acrosome reaction (GO:0007340)11.2192610
170cilium or flagellum-dependent cell motility (GO:0001539)10.9245032
171sperm-egg recognition (GO:0035036)10.7227972
172multicellular organism reproduction (GO:0032504)10.2811696
173piRNA metabolic process (GO:0034587)10.1788680
174acrosome assembly (GO:0001675)10.0311524
175axonemal dynein complex assembly (GO:0070286)10.0282448

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.74514497
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.90819441
3E2F7_22180533_ChIP-Seq_HELA_Human3.70813735
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.17518369
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.72294438
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.64923299
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.57063802
8* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.55519216
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.40521306
10GATA1_26923725_Chip-Seq_HPCs_Mouse2.35185886
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.34768277
12VDR_22108803_ChIP-Seq_LS180_Human2.32272734
13* RACK7_27058665_Chip-Seq_MCF-7_Human2.24049801
14ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.18043921
15LXR_22292898_ChIP-Seq_THP-1_Human2.15185682
16TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.11318391
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.08793628
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.03480571
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.03480571
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.03480571
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.02677905
22* P68_20966046_ChIP-Seq_HELA_Human2.00471285
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.9200641
24RUNX1_27514584_Chip-Seq_MCF-7_Human1.98400647
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96718381
26* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.93704012
27ZNF274_21170338_ChIP-Seq_K562_Hela1.92872132
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.92339942
29EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.89455591
30ELK4_26923725_Chip-Seq_MESODERM_Mouse1.88556523
31ESR1_15608294_ChIP-ChIP_MCF-7_Human1.85157551
32FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83018149
33SMC4_20622854_ChIP-Seq_HELA_Human1.78887383
34ZNF263_19887448_ChIP-Seq_K562_Human1.76504562
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.74180189
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.71516094
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.71359240
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69218739
39CTCF_27219007_Chip-Seq_Bcells_Human1.66517747
40KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.65679373
41STAT1_17558387_ChIP-Seq_HELA_Human1.65398393
42WDR5_24793694_ChIP-Seq_LNCAP_Human1.58617621
43MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.56327218
44TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.55207530
45SOX2_22085726_ChIP-Seq_NPCs_Mouse1.52893393
46KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.52581999
47NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.51962659
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.49719049
49POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.49575286
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49067508
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46592776
52FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.44787093
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44143686
54SOX2_27498859_Chip-Seq_STOMACH_Mouse1.43524807
55GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.42602114
56GATA3_21867929_ChIP-Seq_CD8_Mouse1.42250149
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.41664849
58GATA6_25053715_ChIP-Seq_YYC3_Human1.41596916
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39260621
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39076672
61CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.37310129
62KAP1_22055183_ChIP-Seq_ESCs_Mouse1.35983006
63AR_21909140_ChIP-Seq_LNCAP_Human1.35722041
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35272035
65TCF7_22412390_ChIP-Seq_EML_Mouse1.35094314
66* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.34089362
67CREB1_26743006_Chip-Seq_LNCaP_Human1.33892841
68KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33410661
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31730744
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31727289
71CBP_20019798_ChIP-Seq_JUKART_Human1.31727289
72KDM2B_26808549_Chip-Seq_K562_Human1.29556827
73EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.29045570
74MYC_22102868_ChIP-Seq_BL_Human1.28410233
75RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28020238
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27597582
77SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.27516474
78P53_21459846_ChIP-Seq_SAOS-2_Human1.27486599
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27046130
80TP63_22573176_ChIP-Seq_HFKS_Human1.26421215
81SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.25135261
82CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25123191
83LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.24959608
84SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.24957314
85PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.22691003
86KDM2B_26808549_Chip-Seq_REH_Human1.21468864
87CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20781978
88TAL1_26923725_Chip-Seq_HPCs_Mouse1.20748549
89SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20587268
90RUNX1_26923725_Chip-Seq_HPCs_Mouse1.20177579
91GATA3_21867929_ChIP-Seq_TH1_Mouse1.19908029
92MYC_19079543_ChIP-ChIP_MESCs_Mouse1.19456189
93E2F1_20622854_ChIP-Seq_HELA_Human1.18113819
94SA1_27219007_Chip-Seq_ERYTHROID_Human1.17705381
95SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17677932
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17642229
97KLF5_25053715_ChIP-Seq_YYC3_Human1.16879930
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16438165
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16438165
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.15975271
101VDR_21846776_ChIP-Seq_THP-1_Human1.15904784
102ELK3_25401928_ChIP-Seq_HUVEC_Human1.15074758
103SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13959459
104REST_21632747_ChIP-Seq_MESCs_Mouse1.13839633
105TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13810083
106TP63_17297297_ChIP-ChIP_HaCaT_Human1.13597209
107* CTCF_21964334_Chip-Seq_Bcells_Human1.13432072
108NFE2_27457419_Chip-Seq_LIVER_Mouse1.13256717
109CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12581499
110GF1_26923725_Chip-Seq_HPCs_Mouse1.12391391
111KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12304121
112MYC_18555785_ChIP-Seq_MESCs_Mouse1.12255257
113NANOG_21062744_ChIP-ChIP_HESCs_Human1.11860480
114CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11475802
115SPI1_26923725_Chip-Seq_HPCs_Mouse1.11219528
116ATF3_27146783_Chip-Seq_COLON_Human1.11075592
117RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10514524
118ERG_20517297_ChIP-Seq_VCAP_Human1.09655453
119RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09321790
120KDM2B_26808549_Chip-Seq_DND41_Human1.09201526
121YY1_22570637_ChIP-Seq_MALME-3M_Human1.08991316
122* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08324696
123ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08158273
124ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07970726
125RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07823975
126KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07501814
127NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07258687
128* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.07247331
129* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07176126
130THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05591787
131* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05147809
132FLI1_21867929_ChIP-Seq_TH2_Mouse1.04929751
133* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04917820
134PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03868461
135* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.03528565
136* ETS1_21867929_ChIP-Seq_TH2_Mouse1.03350237
137PKCTHETA_26484144_Chip-Seq_BREAST_Human1.03059528
138EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02904219
139CDX2_20551321_ChIP-Seq_CACO-2_Human1.02679403
140MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02241883
141PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02225671
142SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.01928665
143* MYC_27129775_Chip-Seq_CORNEA_Mouse1.01521032
144SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99489571
145KAP1_27257070_Chip-Seq_ESCs_Mouse0.99451962
146FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99315976
147DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99270324
148EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98862724
149ESET_19884257_ChIP-Seq_ESCs_Mouse0.98732073
150SOX2_21211035_ChIP-Seq_LN229_Human0.97796898
151RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97537094
152ELF1_20517297_ChIP-Seq_JURKAT_Human0.97430602
153SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96856825
154EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.96415084
155SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96013356
156RARA_24833708_ChIP-Seq_LIVER_Mouse0.95311154
157TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95173111
158PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94733200
159* CTCF_20526341_ChIP-Seq_ESCs_Human0.94441905
160* TET1_21451524_ChIP-Seq_MESCs_Mouse0.92670773
161GATA1_19941827_ChIP-Seq_MEL86_Mouse0.91957801
162TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91562965
163RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91472951
164NFYB_21822215_ChIP-Seq_K562_Human0.91440580
165JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.91023539
166LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90476164
167CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89535874
168TBL1_22424771_ChIP-Seq_293T_Human0.89089372
169CBX2_27304074_Chip-Seq_ESCs_Mouse0.88713615
170CRX_20693478_ChIP-Seq_RETINA_Mouse0.88587829
171* SOX11_22085726_ChIP-Seq_ESNs_Mouse0.87921819
172FLI1_21867929_ChIP-Seq_CD8_Mouse0.87891109
173NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.87665066
174TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.87336508
175STAT3_18555785_ChIP-Seq_MESCs_Mouse0.87268215
176CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87121819
177CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85700516
178* NANOG_20526341_ChIP-Seq_ESCs_Human0.85409177
179MYC_19829295_ChIP-Seq_ESCs_Human0.84795177
180BCOR_27268052_Chip-Seq_Bcells_Human0.84284136
181SMAD4_21741376_ChIP-Seq_EPCs_Human0.83155353
182ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83091700
183PHF8_20622854_ChIP-Seq_HELA_Human0.82638363
184NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.82128475

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive5.86623418
2* MP0001929_abnormal_gametogenesis5.49082077
3MP0008877_abnormal_DNA_methylation5.36451744
4MP0010234_abnormal_vibrissa_follicle3.78446875
5MP0003718_maternal_effect3.68511732
6* MP0002210_abnormal_sex_determination3.65613674
7MP0002254_reproductive_system_inflammat3.47335391
8MP0004264_abnormal_extraembryonic_tissu3.38497634
9* MP0002161_abnormal_fertility/fecundity3.28213029
10MP0002653_abnormal_ependyma_morphology3.18570495
11* MP0001145_abnormal_male_reproductive3.05807389
12MP0002796_impaired_skin_barrier2.71419027
13* MP0000653_abnormal_sex_gland2.68462073
14MP0000566_synostosis2.65274570
15MP0005670_abnormal_white_adipose2.52812660
16MP0003646_muscle_fatigue2.51566818
17MP0005360_urolithiasis2.31836271
18MP0003705_abnormal_hypodermis_morpholog2.22254675
19MP0000678_abnormal_parathyroid_gland2.15344991
20MP0010030_abnormal_orbit_morphology2.14067261
21MP0005410_abnormal_fertilization15.2270975
22MP0001666_abnormal_nutrient_absorption1.84897235
23MP0002098_abnormal_vibrissa_morphology1.84379338
24MP0005501_abnormal_skin_physiology1.83665573
25MP0004185_abnormal_adipocyte_glucose1.78221621
26MP0003941_abnormal_skin_development1.73805553
27MP0002160_abnormal_reproductive_system1.71018375
28MP0000537_abnormal_urethra_morphology1.70874351
29MP0009379_abnormal_foot_pigmentation1.65833615
30MP0005076_abnormal_cell_differentiation1.65405836
31MP0005409_darkened_coat_color1.58244189
32MP0002249_abnormal_larynx_morphology1.57124257
33MP0005623_abnormal_meninges_morphology1.54754441
34MP0008995_early_reproductive_senescence1.44020451
35MP0001346_abnormal_lacrimal_gland1.42136591
36MP0002282_abnormal_trachea_morphology1.39366064
37MP0004233_abnormal_muscle_weight1.35619857
38MP0002139_abnormal_hepatobiliary_system1.34390965
39MP0001664_abnormal_digestion1.28981215
40MP0000579_abnormal_nail_morphology1.27421273
41MP0000462_abnormal_digestive_system1.26796567
42MP0003183_abnormal_peptide_metabolism1.25948904
43MP0003119_abnormal_digestive_system1.23477125
44MP0010352_gastrointestinal_tract_polyps1.22318813
45MP0008932_abnormal_embryonic_tissue1.19437592
46MP0004782_abnormal_surfactant_physiolog1.16444112
47MP0005395_other_phenotype1.15360632
48MP0010678_abnormal_skin_adnexa1.14495743
49MP0003878_abnormal_ear_physiology1.09819202
50MP0005377_hearing/vestibular/ear_phenot1.09819202
51MP0004019_abnormal_vitamin_homeostasis1.08454721
52MP0010094_abnormal_chromosome_stability1.07474719
53MP0000377_abnormal_hair_follicle1.07369831
54MP0000477_abnormal_intestine_morphology1.06948467
55MP0002089_abnormal_postnatal_growth/wei1.06740976
56MP0005647_abnormal_sex_gland1.05541487
57MP0008058_abnormal_DNA_repair1.05015444
58MP0001881_abnormal_mammary_gland1.02033783
59MP0000762_abnormal_tongue_morphology1.01671018
60MP0001765_abnormal_ion_homeostasis1.01189142
61MP0004858_abnormal_nervous_system0.99340720
62MP0000467_abnormal_esophagus_morphology0.97940993
63MP0003890_abnormal_embryonic-extraembry0.93884750
64MP0002822_catalepsy0.92934879
65MP0000490_abnormal_crypts_of0.92323569
66MP0008057_abnormal_DNA_replication0.91917430
67MP0001188_hyperpigmentation0.90009359
68MP0003115_abnormal_respiratory_system0.89297521
69MP0000350_abnormal_cell_proliferation0.88290036
70MP0003111_abnormal_nucleus_morphology0.88023240
71MP0005389_reproductive_system_phenotype0.86910846
72MP0000383_abnormal_hair_follicle0.86338039
73MP0000627_abnormal_mammary_gland0.85128249
74MP0001984_abnormal_olfaction0.83990818
75MP0005083_abnormal_biliary_tract0.82577530
76MP0002697_abnormal_eye_size0.79889549
77MP0005666_abnormal_adipose_tissue0.78172791
78MP0000427_abnormal_hair_cycle0.76334251
79MP0003786_premature_aging0.76306670
80MP0004270_analgesia0.74982585
81MP0000470_abnormal_stomach_morphology0.74927544
82MP0002086_abnormal_extraembryonic_tissu0.74563970
83MP0000049_abnormal_middle_ear0.73174311
84MP0003453_abnormal_keratinocyte_physiol0.72667590
85MP0009278_abnormal_bone_marrow0.72132314
86MP0001348_abnormal_lacrimal_gland0.72006312
87MP0004036_abnormal_muscle_relaxation0.70178191
88MP0000003_abnormal_adipose_tissue0.68906646
89MP0008789_abnormal_olfactory_epithelium0.68529413
90MP0005394_taste/olfaction_phenotype0.68379639
91MP0005499_abnormal_olfactory_system0.68379639
92MP0002234_abnormal_pharynx_morphology0.66951345
93MP0000569_abnormal_digit_pigmentation0.62425059
94* MP0003699_abnormal_female_reproductive0.60607157
95MP0001730_embryonic_growth_arrest0.60218105
96MP0000358_abnormal_cell_content/0.58860916
97MP0000751_myopathy0.58477325
98MP0001545_abnormal_hematopoietic_system0.58400337
99MP0005397_hematopoietic_system_phenotyp0.58400337
100MP0002269_muscular_atrophy0.57193333
101MP0008007_abnormal_cellular_replicative0.55470897
102MP0009046_muscle_twitch0.55130086
103MP0003077_abnormal_cell_cycle0.53903258
104MP0003950_abnormal_plasma_membrane0.51670087
105MP0003011_delayed_dark_adaptation0.50789747
106MP0003329_amyloid_beta_deposits0.50753332
107MP0001727_abnormal_embryo_implantation0.48776023
108MP0001293_anophthalmia0.47770519
109MP0000534_abnormal_ureter_morphology0.44683172
110MP0005636_abnormal_mineral_homeostasis0.44185989
111MP0006036_abnormal_mitochondrial_physio0.42448675
112MP0003942_abnormal_urinary_system0.41884967
113MP0008961_abnormal_basal_metabolism0.41158738
114MP0002102_abnormal_ear_morphology0.39392442
115MP0002084_abnormal_developmental_patter0.39101334
116MP0003879_abnormal_hair_cell0.38883306
117MP0001324_abnormal_eye_pigmentation0.37962147
118* MP0001119_abnormal_female_reproductive0.37891742
119MP0005380_embryogenesis_phenotype0.37472138
120MP0001672_abnormal_embryogenesis/_devel0.37472138
121MP0002928_abnormal_bile_duct0.36644396
122MP0001849_ear_inflammation0.36163894
123MP0003693_abnormal_embryo_hatching0.35642324
124MP0009115_abnormal_fat_cell0.35422011
125MP0001697_abnormal_embryo_size0.35007027
126MP0002971_abnormal_brown_adipose0.34810903
127MP0003861_abnormal_nervous_system0.34295048
128MP0004084_abnormal_cardiac_muscle0.32160616
129MP0001764_abnormal_homeostasis0.31986599
130MP0010307_abnormal_tumor_latency0.31681267
131MP0004087_abnormal_muscle_fiber0.31128912
132MP0004808_abnormal_hematopoietic_stem0.30261361
133MP0005375_adipose_tissue_phenotype0.30161633
134MP0005253_abnormal_eye_physiology0.29585655
135MP0000313_abnormal_cell_death0.29163700
136MP0004957_abnormal_blastocyst_morpholog0.29015994
137MP0002106_abnormal_muscle_physiology0.28836917
138MP0005391_vision/eye_phenotype0.28829686
139MP0002085_abnormal_embryonic_tissue0.28284308
140MP0003984_embryonic_growth_retardation0.27629576
141MP0001661_extended_life_span0.25786122
142MP0002080_prenatal_lethality0.25609058
143MP0002088_abnormal_embryonic_growth/wei0.25209384
144MP0010630_abnormal_cardiac_muscle0.24789732
145MP0002152_abnormal_brain_morphology0.23581242
146MP0009672_abnormal_birth_weight0.22671602
147MP0002092_abnormal_eye_morphology0.21643910
148MP0002295_abnormal_pulmonary_circulatio0.21621128
149MP0005551_abnormal_eye_electrophysiolog0.21468409
150MP0003045_fibrosis0.21036912
151MP0003936_abnormal_reproductive_system0.20844016
152MP0006138_congestive_heart_failure0.20839853
153MP0004043_abnormal_pH_regulation0.20819733
154MP0005451_abnormal_body_composition0.20743422
155MP0004197_abnormal_fetal_growth/weight/0.20704376
156MP0004133_heterotaxia0.20406874
157MP0002169_no_abnormal_phenotype0.20190896
158MP0004145_abnormal_muscle_electrophysio0.20165411
159MP0002873_normal_phenotype0.19879887
160MP0006035_abnormal_mitochondrial_morpho0.19133795

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.88099824
2Abnormal respiratory motile cilium morphology (HP:0005938)8.83293863
3Abnormal respiratory epithelium morphology (HP:0012253)8.83293863
4Rhinitis (HP:0012384)7.46030145
5Infertility (HP:0000789)7.15778599
6Chronic bronchitis (HP:0004469)6.95374668
7Abnormal ciliary motility (HP:0012262)6.89138537
8Nasal polyposis (HP:0100582)6.25063338
9Male infertility (HP:0003251)5.45374728
10Abnormality of the nasal mucosa (HP:0000433)5.13643957
11Nephronophthisis (HP:0000090)4.52585224
12Bronchiectasis (HP:0002110)4.48044187
13Bronchitis (HP:0012387)4.46206273
14Abnormal spermatogenesis (HP:0008669)3.91622544
15Abnormality of the renal medulla (HP:0100957)3.42530480
16Pili torti (HP:0003777)3.34803301
17Hyperactive renin-angiotensin system (HP:0000841)3.30786182
18Gonadotropin excess (HP:0000837)3.26759450
19Recurrent otitis media (HP:0000403)3.22410408
20Impulsivity (HP:0100710)3.11359716
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.10030698
22Right ventricular cardiomyopathy (HP:0011663)3.09271637
23Flat acetabular roof (HP:0003180)2.96339205
24Recurrent sinusitis (HP:0011108)2.94216891
25Tubulointerstitial nephritis (HP:0001970)2.91602356
26Recurrent bronchitis (HP:0002837)2.80094010
27Malnutrition (HP:0004395)2.79519432
28Tubular atrophy (HP:0000092)2.74633055
29Turricephaly (HP:0000262)2.73244571
30Thin bony cortex (HP:0002753)2.70277338
31Azoospermia (HP:0000027)2.69952379
32Choanal stenosis (HP:0000452)2.62964810
33Abnormality of midbrain morphology (HP:0002418)2.60357044
34Molar tooth sign on MRI (HP:0002419)2.60357044
35Abnormality of the lower motor neuron (HP:0002366)2.56638171
36Lip pit (HP:0100267)2.53293501
37Delayed epiphyseal ossification (HP:0002663)2.52614253
38Widely patent fontanelles and sutures (HP:0004492)2.51926966
39Tubulointerstitial abnormality (HP:0001969)2.51858446
40Hyperkalemia (HP:0002153)2.51646011
41Hyperglycinuria (HP:0003108)2.48848562
42Wide cranial sutures (HP:0010537)2.46023048
43Partial duplication of thumb phalanx (HP:0009944)2.42875463
44High anterior hairline (HP:0009890)2.40309097
45Abdominal distention (HP:0003270)2.39404381
46Osteomalacia (HP:0002749)2.38070690
47Bronchomalacia (HP:0002780)2.33288768
48Abnormality of abdominal situs (HP:0011620)2.33100782
49Abdominal situs inversus (HP:0003363)2.33100782
50Abnormality of the salivary glands (HP:0010286)2.30285229
51Cholecystitis (HP:0001082)2.28144103
52Abnormal gallbladder physiology (HP:0012438)2.28144103
53Septate vagina (HP:0001153)2.26619056
54Hyponatremia (HP:0002902)2.22868497
55Cone-rod dystrophy (HP:0000548)2.19423430
56Abnormality of renin-angiotensin system (HP:0000847)2.19185280
57Progressive sensorineural hearing impairment (HP:0000408)2.17597512
58Distal lower limb muscle weakness (HP:0009053)2.17126884
59Germ cell neoplasia (HP:0100728)2.15707965
60Medial flaring of the eyebrow (HP:0010747)2.13025970
61Spastic tetraparesis (HP:0001285)2.13024586
62Bicornuate uterus (HP:0000813)2.11425218
63Enlarged penis (HP:0000040)2.10419105
64Abnormality of the distal phalanx of the thumb (HP:0009617)2.10036149
65Increased purine levels (HP:0004368)2.08959042
66Hyperuricemia (HP:0002149)2.08959042
67Distal upper limb amyotrophy (HP:0007149)2.08916023
68Upper limb amyotrophy (HP:0009129)2.08916023
69Heterotopia (HP:0002282)2.06513783
70Myopathic facies (HP:0002058)2.04591081
71Maternal diabetes (HP:0009800)2.04496044
72Tubulointerstitial fibrosis (HP:0005576)2.04251179
73Amelogenesis imperfecta (HP:0000705)2.03757742
74Amyotrophic lateral sclerosis (HP:0007354)2.01038482
75Stage 5 chronic kidney disease (HP:0003774)2.00642733
76Absent/shortened dynein arms (HP:0200106)12.9528532
77Dynein arm defect of respiratory motile cilia (HP:0012255)12.9528532
78Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.6576145
79Postaxial foot polydactyly (HP:0001830)1.98060085
80Hypoplasia of the capital femoral epiphysis (HP:0003090)1.96882088
81Abnormal hair laboratory examination (HP:0003328)1.95721094
82Renovascular hypertension (HP:0100817)1.94386803
83Partial duplication of the phalanx of hand (HP:0009999)1.91297803
84Facial hemangioma (HP:0000329)1.90537629
85Fibular hypoplasia (HP:0003038)1.90491192
86Shallow orbits (HP:0000586)1.88587462
87Abnormal drinking behavior (HP:0030082)1.87996542
88Polydipsia (HP:0001959)1.87996542
89Hypophosphatemic rickets (HP:0004912)1.87571784
90Chromosomal breakage induced by crosslinking agents (HP:0003221)1.87010314
91Dysmetric saccades (HP:0000641)1.86687699
92Decreased circulating renin level (HP:0003351)1.86266518
93Abnormality of proline metabolism (HP:0010907)1.86123803
94Hydroxyprolinuria (HP:0003080)1.86123803
95Abnormality of the aortic arch (HP:0012303)1.85977742
96Short ribs (HP:0000773)1.85785234
97Breast carcinoma (HP:0003002)1.84896288
98Dyschromatopsia (HP:0007641)1.84598564
99Abnormality of serine family amino acid metabolism (HP:0010894)1.84311385
100Abnormality of glycine metabolism (HP:0010895)1.84311385
101Gastrointestinal carcinoma (HP:0002672)1.84223230
102Malignant gastrointestinal tract tumors (HP:0006749)1.84223230
103Midline defect of the nose (HP:0004122)1.82300054
104Abnormality of sodium homeostasis (HP:0010931)1.81874304
105Abnormality of potassium homeostasis (HP:0011042)1.78941272
106Urethral obstruction (HP:0000796)1.78561987
107Abnormality of chloride homeostasis (HP:0011422)1.77355156
108Ventricular tachycardia (HP:0004756)1.76744602
109Atresia of the external auditory canal (HP:0000413)1.76648432
110Pterygium (HP:0001059)1.76636707
111Abnormal urine phosphate concentration (HP:0012599)1.76534529
112External ophthalmoplegia (HP:0000544)1.75714433
113Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.75125588
114Subcapsular cataract (HP:0000523)1.75044268
115Congenital hepatic fibrosis (HP:0002612)1.74838403
116Abnormality of the renal cortex (HP:0011035)1.74547577
117Progressive hearing impairment (HP:0001730)1.74207764
118Abnormality of monocarboxylic acid metabolism (HP:0010996)1.74133638
119Choroideremia (HP:0001139)1.74044721
120Broad metatarsal (HP:0001783)1.73563078
121Hyperparathyroidism (HP:0000843)1.73238631
122Nephroblastoma (Wilms tumor) (HP:0002667)1.72647454
123Bell-shaped thorax (HP:0001591)1.71450804
124Increased nuchal translucency (HP:0010880)1.70956157
125Septo-optic dysplasia (HP:0100842)1.70690175
126Lymphangioma (HP:0100764)1.70488636
127Oculomotor apraxia (HP:0000657)1.70058303
128Duplication of thumb phalanx (HP:0009942)1.70016054
129Asymmetry of the thorax (HP:0001555)1.69766125
130Abnormal biliary tract physiology (HP:0012439)1.69403640
131Bile duct proliferation (HP:0001408)1.69403640
132Embryonal neoplasm (HP:0002898)1.69400026
133Centrally nucleated skeletal muscle fibers (HP:0003687)1.69139893
134Abnormality of sulfur amino acid metabolism (HP:0004339)1.68805782
135Severe visual impairment (HP:0001141)1.68227072
136Hyperacusis (HP:0010780)1.67515604
137Chromsome breakage (HP:0040012)1.66909572
138Hand muscle atrophy (HP:0009130)1.66674586
139Proximal tubulopathy (HP:0000114)1.66381215
140Abnormality of the phalanges of the hallux (HP:0010057)1.66199474
141Impaired proprioception (HP:0010831)1.64948279
142Renal dysplasia (HP:0000110)1.63862052
143Diaphragmatic weakness (HP:0009113)1.63437020
144Abnormality of dentin (HP:0010299)1.62694436
145Spinal cord compression (HP:0002176)1.61581571
146Absent radius (HP:0003974)1.61553318
147Coronal craniosynostosis (HP:0004440)1.60811993
148Hypophosphatemia (HP:0002148)1.60250956
149Esophageal varix (HP:0002040)1.58621918
150Abnormality of renal excretion (HP:0011036)1.58577454
151Absent frontal sinuses (HP:0002688)1.55419063
152Microglossia (HP:0000171)1.53415379
153Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.53400181
154Absent epiphyses (HP:0010577)1.53400181
155Deformed sella turcica (HP:0002681)1.52321572
156Bundle branch block (HP:0011710)1.50193015
157Supernumerary spleens (HP:0009799)1.49951080
158Exercise-induced myalgia (HP:0003738)1.48944805
159Abnormality of permanent molar morphology (HP:0011071)1.48706706
160Abnormality of the dental root (HP:0006486)1.48706706
161Taurodontia (HP:0000679)1.48706706
162Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.46363995
163Hemorrhage of the eye (HP:0011885)1.45953849
164Decreased central vision (HP:0007663)1.45928356
165Postaxial hand polydactyly (HP:0001162)1.45198659
166Facial cleft (HP:0002006)1.44741611
167Asymmetric septal hypertrophy (HP:0001670)1.42527902
168Short thorax (HP:0010306)1.42133870
169Cystic liver disease (HP:0006706)1.40899797
170J-shaped sella turcica (HP:0002680)1.38692512
171Abnormal urine output (HP:0012590)1.38492731
172Difficulty climbing stairs (HP:0003551)1.38210507
173Abnormality of molar (HP:0011077)1.36285772
174Abnormality of molar morphology (HP:0011070)1.36285772
175Broad distal phalanx of finger (HP:0009836)1.35932888
176Abnormality of the dental pulp (HP:0006479)1.34508285
177Hemiparesis (HP:0001269)1.33516768
178Neurofibrillary tangles (HP:0002185)1.33248028
179Decreased electroretinogram (ERG) amplitude (HP:0000654)1.30546431
180EMG: neuropathic changes (HP:0003445)1.27789427
181Easy fatigability (HP:0003388)1.25836636
182Cerebellar dysplasia (HP:0007033)1.23630288
183Short femoral neck (HP:0100864)1.22980510
184Myoglobinuria (HP:0002913)1.22698110
185Median cleft lip (HP:0000161)1.22157364
186Upper motor neuron abnormality (HP:0002127)1.21599446
187Hyporeflexia of lower limbs (HP:0002600)1.20468783
188Pachygyria (HP:0001302)1.20394998
189Aplasia/Hypoplasia of the tongue (HP:0010295)1.19890407
190Nephropathy (HP:0000112)1.19633895
191Polyuria (HP:0000103)1.19026554
192Truncal obesity (HP:0001956)1.18726670
193Short nail (HP:0001799)1.18522321
194Aplasia/Hypoplasia of the lens (HP:0008063)1.17588591

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.14868881
2PDK38.14868881
3TESK15.51114212
4PRKD35.46777150
5PDK25.21930516
6ICK4.57561812
7EPHA23.05927885
8SMG12.65261865
9MST1R2.49947695
10PNCK2.35121321
11PKN22.33206755
12SIK12.25925821
13PTK2B2.24824210
14MAP3K92.24281337
15WNK42.23406866
16MET2.14177655
17RIPK11.99404759
18STK391.97462840
19RPS6KB21.93239286
20NEK21.92584346
21STK381.73524947
22CDK71.71116260
23FGFR41.58046251
24BRD41.42443918
25MAP2K21.41370456
26PRKG21.40408375
27NME11.38200833
28DYRK1B1.37300259
29VRK21.20949044
30TYRO31.20541000
31DDR21.08041539
32MAPK151.06933859
33PTK61.06264070
34ERN11.01003738
35ARAF0.99544371
36WNK10.98241806
37PTK20.97249267
38PDK10.95418859
39STK30.95410805
40PIK3CA0.90843803
41TTK0.89593838
42BMX0.88107642
43FGFR20.86618174
44OXSR10.86558544
45DYRK30.86299603
46CDC70.85665316
47PRKCI0.81314296
48DMPK0.81292768
49TAF10.81193945
50CDK190.76023180
51STK38L0.75980917
52EEF2K0.72572722
53CAMK1G0.72025168
54CAMK1D0.71190772
55MAP3K80.68568336
56PBK0.68544587
57CHEK20.68392497
58TSSK60.68094436
59STK240.67528169
60PDGFRA0.65899579
61RPS6KA20.65895216
62PASK0.65446649
63PINK10.65171570
64MAP3K130.63658998
65CCNB10.61239015
66CDK120.58192520
67KSR20.58048512
68LMTK20.51649806
69RET0.50270186
70PDPK10.50223453
71SRPK10.49040935
72EPHB20.48729485
73ILK0.48612485
74WEE10.48340071
75PRPF4B0.44453862
76TESK20.43883203
77ATR0.43218962
78MTOR0.42406613
79MUSK0.41075293
80FGFR10.40529716
81PAK10.39757487
82ATM0.39446582
83PLK40.39265690
84AKT20.38612334
85TNIK0.38210394
86LATS10.38169839
87* CHEK10.37963922
88NTRK20.35504170
89RPS6KC10.34984710
90RPS6KL10.34984710
91MAPK140.34780945
92MAP2K60.34558055
93CSNK1E0.33870307
94PRKAA10.33073508
95PRKAA20.32096268
96TAOK10.31833611
97PAK20.30536931
98IRAK10.30308236
99PLK10.29115157
100MARK20.25438336
101PAK40.24926221
102LATS20.21525639
103PRKCG0.18858874
104PAK60.17549936
105TRIB30.17508429
106RIPK40.16875358
107MAP3K100.16238066
108BRAF0.15123373
109RPS6KB10.13198935
110WNK30.13182838
111MAPKAPK50.13125798
112CDK40.12068592
113CDK20.11801507
114CAMKK10.10666546
115RPS6KA10.09740968
116MAP3K60.09703790
117MAP3K40.09634362
118CDK10.09353796
119GSK3B0.08639696
120PRKCZ0.08062341
121CSNK1D0.07946467
122IRAK20.07715370
123BUB10.07339037
124CDK150.06710286
125STK110.05978972
126CDK60.05785623
127STK100.05383392
128MAP3K50.05237940
129BRSK20.04525234
130BRSK10.04203144
131CDK180.04192856
132CSNK2A10.04130671
133NEK60.03920782
134CDK11A0.03844738
135AURKA0.02222174
136MAPK80.01812925
137PRKDC0.01698736
138CDK90.01245866
139CDK30.00496751
140PRKD20.00367162
141MAPKAPK30.00178671
142PDGFRB-0.0210264
143TTN-0.0203687
144CSNK2A2-0.0182542
145PIM1-0.0148004
146BMPR1B-0.0144344
147RPS6KA3-0.0139423
148CDK14-0.0102105
149PRKACB-0.0090900
150MAPK1-0.0059528
151AURKB-0.0046559

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.39357272
2Cyanoamino acid metabolism_Homo sapiens_hsa004604.21612166
3Fatty acid biosynthesis_Homo sapiens_hsa000614.14900030
4Pyruvate metabolism_Homo sapiens_hsa006203.85086891
5Vitamin B6 metabolism_Homo sapiens_hsa007503.78124863
6Propanoate metabolism_Homo sapiens_hsa006403.02542859
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.92976313
8Dorso-ventral axis formation_Homo sapiens_hsa043202.92404322
9Linoleic acid metabolism_Homo sapiens_hsa005912.79695339
10Glucagon signaling pathway_Homo sapiens_hsa049222.70413331
11Basal transcription factors_Homo sapiens_hsa030222.65583156
12Arginine biosynthesis_Homo sapiens_hsa002202.24141815
13Selenocompound metabolism_Homo sapiens_hsa004502.18727439
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.14635381
15Vitamin digestion and absorption_Homo sapiens_hsa049772.13265298
16Carbohydrate digestion and absorption_Homo sapiens_hsa049732.05327338
17Oocyte meiosis_Homo sapiens_hsa041142.00593173
18Thyroid cancer_Homo sapiens_hsa052161.99507663
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.98547468
20Glycerolipid metabolism_Homo sapiens_hsa005611.92274731
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.92212663
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.89590935
23Fanconi anemia pathway_Homo sapiens_hsa034601.88680067
24Tight junction_Homo sapiens_hsa045301.77967277
25PPAR signaling pathway_Homo sapiens_hsa033201.70449918
26Glycerophospholipid metabolism_Homo sapiens_hsa005641.69437699
27Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.67576052
28mRNA surveillance pathway_Homo sapiens_hsa030151.63226334
29Arginine and proline metabolism_Homo sapiens_hsa003301.59852244
30Sulfur relay system_Homo sapiens_hsa041221.58861659
31RNA transport_Homo sapiens_hsa030131.58546461
32Pentose phosphate pathway_Homo sapiens_hsa000301.56810476
33Fructose and mannose metabolism_Homo sapiens_hsa000511.53961786
34Fatty acid metabolism_Homo sapiens_hsa012121.47922080
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.47586300
36Carbon metabolism_Homo sapiens_hsa012001.44198277
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.42101845
38Fatty acid degradation_Homo sapiens_hsa000711.40723831
39Cardiac muscle contraction_Homo sapiens_hsa042601.36080748
40Amphetamine addiction_Homo sapiens_hsa050311.31047833
41Endometrial cancer_Homo sapiens_hsa052131.26671532
42Adherens junction_Homo sapiens_hsa045201.26061460
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.25800402
44Huntingtons disease_Homo sapiens_hsa050161.25235546
45Lysine degradation_Homo sapiens_hsa003101.24003348
46Ether lipid metabolism_Homo sapiens_hsa005651.23924807
47Antigen processing and presentation_Homo sapiens_hsa046121.21341836
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.19396994
49Galactose metabolism_Homo sapiens_hsa000521.18964563
50Phenylalanine metabolism_Homo sapiens_hsa003601.18718915
51Notch signaling pathway_Homo sapiens_hsa043301.17563225
52Fat digestion and absorption_Homo sapiens_hsa049751.17347616
53Mineral absorption_Homo sapiens_hsa049781.15486450
54Histidine metabolism_Homo sapiens_hsa003401.04715564
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02539354
56Renin secretion_Homo sapiens_hsa049241.01924214
57Mismatch repair_Homo sapiens_hsa034301.01633236
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01596755
59Purine metabolism_Homo sapiens_hsa002300.95682032
60Hedgehog signaling pathway_Homo sapiens_hsa043400.94767979
61Folate biosynthesis_Homo sapiens_hsa007900.89961476
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89453330
63Biosynthesis of amino acids_Homo sapiens_hsa012300.88787691
64Hippo signaling pathway_Homo sapiens_hsa043900.86568505
65Estrogen signaling pathway_Homo sapiens_hsa049150.82900181
66Sulfur metabolism_Homo sapiens_hsa009200.82509513
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82128623
68Gap junction_Homo sapiens_hsa045400.78347972
69Ovarian steroidogenesis_Homo sapiens_hsa049130.77578284
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.77018153
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.76765609
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.75357872
73Long-term potentiation_Homo sapiens_hsa047200.70886635
74Prostate cancer_Homo sapiens_hsa052150.68927695
75Starch and sucrose metabolism_Homo sapiens_hsa005000.67768940
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66997686
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66992455
78Glutathione metabolism_Homo sapiens_hsa004800.66953815
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66950561
80Spliceosome_Homo sapiens_hsa030400.64884715
81Arachidonic acid metabolism_Homo sapiens_hsa005900.63529123
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63241820
83ErbB signaling pathway_Homo sapiens_hsa040120.62719982
84RNA degradation_Homo sapiens_hsa030180.62532939
85Bladder cancer_Homo sapiens_hsa052190.62211171
86AMPK signaling pathway_Homo sapiens_hsa041520.61045604
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60067348
88VEGF signaling pathway_Homo sapiens_hsa043700.60020029
89MicroRNAs in cancer_Homo sapiens_hsa052060.59237598
90Cell cycle_Homo sapiens_hsa041100.58737280
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56910729
92Acute myeloid leukemia_Homo sapiens_hsa052210.55588481
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55205952
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54195910
95Retinol metabolism_Homo sapiens_hsa008300.54059312
96Melanogenesis_Homo sapiens_hsa049160.53562774
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53153197
98Legionellosis_Homo sapiens_hsa051340.52115121
99Caffeine metabolism_Homo sapiens_hsa002320.51971138
100Chronic myeloid leukemia_Homo sapiens_hsa052200.48409026
101Insulin secretion_Homo sapiens_hsa049110.47951844
102Bile secretion_Homo sapiens_hsa049760.47915901
103ABC transporters_Homo sapiens_hsa020100.47784323
104Thyroid hormone synthesis_Homo sapiens_hsa049180.46928902
105Endocytosis_Homo sapiens_hsa041440.45435682
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44355021
107Fatty acid elongation_Homo sapiens_hsa000620.42938792
108Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42793160
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42632475
110Chemical carcinogenesis_Homo sapiens_hsa052040.41943936
111mTOR signaling pathway_Homo sapiens_hsa041500.41815414
112Calcium signaling pathway_Homo sapiens_hsa040200.41503551
113Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40896873
114Non-small cell lung cancer_Homo sapiens_hsa052230.40358650
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39812478
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39477845
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39311498
118Inositol phosphate metabolism_Homo sapiens_hsa005620.39112098
119Axon guidance_Homo sapiens_hsa043600.38654739
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.36636027
121Pyrimidine metabolism_Homo sapiens_hsa002400.36018165
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35351653
123Protein digestion and absorption_Homo sapiens_hsa049740.34302914
124Homologous recombination_Homo sapiens_hsa034400.31932582
125Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.31919593
126Basal cell carcinoma_Homo sapiens_hsa052170.30614729
127Collecting duct acid secretion_Homo sapiens_hsa049660.29496317
128Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28743355
129Pancreatic secretion_Homo sapiens_hsa049720.27620603
130Metabolic pathways_Homo sapiens_hsa011000.27088319
131cAMP signaling pathway_Homo sapiens_hsa040240.26732690
132Renin-angiotensin system_Homo sapiens_hsa046140.26287807
133Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24697633
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23996182
135Wnt signaling pathway_Homo sapiens_hsa043100.23696680
136Salivary secretion_Homo sapiens_hsa049700.22775741
137Gastric acid secretion_Homo sapiens_hsa049710.22052027
138HIF-1 signaling pathway_Homo sapiens_hsa040660.21864603
139Taste transduction_Homo sapiens_hsa047420.16959668
140DNA replication_Homo sapiens_hsa030300.14712992
141Insulin resistance_Homo sapiens_hsa049310.13239037
142Pentose and glucuronate interconversions_Homo sapiens_hsa000400.12202426
143Systemic lupus erythematosus_Homo sapiens_hsa053220.11087900
144Base excision repair_Homo sapiens_hsa034100.09498316
145Insulin signaling pathway_Homo sapiens_hsa049100.08836762
146Epstein-Barr virus infection_Homo sapiens_hsa051690.08535474

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